Excitation and detection methods for analyzing biomolecules
WO2026039088A3PCT designated stage Publication Date: 2026-05-21ESBIOLAB LLC
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- ESBIOLAB LLC
- Filing Date
- 2025-06-02
- Publication Date
- 2026-05-21
AI Technical Summary
Technical Problem
Distinguishing luminophores with similar spectrums using luminescence intensity alone is challenging, requiring complex optical systems for excitation and emission detection, which can be costly and time-consuming.
Method used
Methods for analyzing molecules by detecting intensities of luminophores with overlapping spectrums using intensity characteristics, allowing identification with simplified optical systems by leveraging intensity characteristics at multiple points along a luminophore's spectrum.
Benefits of technology
Simplifies optical systems, reduces costs, and decreases detection time by enabling identification of multiple luminophores with overlapping spectrums using a single wavelength, thereby reducing the need for multiple detectors and excitation sources.
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Figure US2025031916_21052026_PF_FP_ABST
Abstract
Methods for analyzing molecules are described, including method of analysis using luminophores with spectral overlap. The methods may comprise, for example, contacting the molecules with binders, wherein the binders are labeled with luminophores that have different but overlapping spectrums of emission and / or excitation wavelengths, and determining intensity characteristics from the luminophore's intensities to determine the binders and the corresponding bound targets in the molecules. In addition, the methods described herein are compatible with next-generation sequencing methods, such as sequencing-by-synthesis for the analysis of different nucleic acid analytes, including one or more nucleic acid templates to be sequenced.
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