Novel system for non-invasive drug delivery

Abstract

The present invention relates to a novel drug delivery system using a monoparticulate solid carrier, in particular a co-processed excipient for the non-invasive administration of active pharmaceutical ingredients (APIs). The monoparticulate co-processed excipient comprises lactose and cellulose, or a derivative of cellulose (in particular Hydroxypropylmethylcellulose, HPMC), or comprises a polyol and cellulose, or a derivative of cellulose (in particular, HPMC). The invention relates in particular to the non-invasive administration of APIs using the coprocessed excipient as carrier into body cavities, in particular body cavities comprising a mucosal lining. More specifically, the invention relates to the administration of APIs by insufflation of the co-processed excipient carrying an API into such body cavities. The novel drug delivery system of the present invention relates in particular to the nasal administration of APIs.

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