Silica encapsulated biomolecules
The use of functionalized silica precursors in a biomolecule-specific encapsulation process addresses the degradation issues of biomolecules by forming a stable, shape-matching silica shell, ensuring effective protection and stability without cold chain reliance.
WO2026093345A1PCT designated stage Publication Date: 2026-05-07ENSILICATED TECHNOLOGIES LTD
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- ENSILICATED TECHNOLOGIES LTD
- Filing Date
- 2025-10-28
- Publication Date
- 2026-05-07
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Figure EP2025081185_07052026_PF_FP_ABST
Abstract
A particle comprising a biomolecule encapsulated in a silica shell which is directly deposited about the surface of the biomolecule, and wherein at least a portion of the interior surface of the silica shell is functionalised and comprises a Si-C bond. The particle can be used to stabilize a biomolecule for transport and / or storage. The biomolecule can be released from the silica shell prior to administration to a subject. The particles may be formed by mixing and hydrolysing a functionalised and non-functionalised silica precursor, and contacting the mixture of hydrolysed precursors with a biomolecule.
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Citation Information
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