Internalin-like protein from barnesiella intestinihominis and medical uses thereof
The internalin-like protein from Barnesiella intestinihominis addresses the undefined barrier protective effects by enhancing intestinal barrier function and repair, effectively treating diseases related to intestinal permeability.
WO2026104808A1PCT designated stage Publication Date: 2026-05-21MICROBIOTICA LTD
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- MICROBIOTICA LTD
- Filing Date
- 2025-11-12
- Publication Date
- 2026-05-21
AI Technical Summary
Technical Problem
The underlying modalities of barrier protective effects of certain bacterial species on the gut epithelial barrier remain undefined, leading to increased permeability and potential systemic effects in disorders such as inflammatory and autoimmune diseases.
Method used
An internalin-like protein derived from Barnesiella intestinihominis, with specific amino acid sequences, is used to enhance intestinal barrier function by inducing the expression of tight junction proteins.
Benefits of technology
The internalin-like protein effectively enhances epithelial barrier functions, reducing permeability and promoting barrier repair, applicable in treating various diseases associated with intestinal barrier dysfunction.
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Smart Images
Figure GB2025052462_21052026_PF_FP_ABST
Abstract
The invention relates to an isolated protein comprising or consisting of an internalin-like peptide domain which improves intestinal barrier repair by enhancing epithelial barrier functions such as inducing the expression of tight junction proteins.
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