Compositions, systems and methods relating to the identification of HLA class ii-binding peptides
WO2026107186A1PCT designated stage Publication Date: 2026-05-21THE BRIGHAM & WOMEN S HOSPITAL INC
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- THE BRIGHAM & WOMEN S HOSPITAL INC
- Filing Date
- 2025-11-13
- Publication Date
- 2026-05-21
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Figure US2025055319_21052026_PF_FP_ABST
Abstract
The technology described herein is directed to compositions and methods for generating synthetic antigen presenting cells (APCs) that express a single HLA-II allotype and key genes for HLA-II processing and presentation, and express no other HLA-II allele. Further disclosed are systems and methods of using the synthetic APCs for identifying allele-specific HLA Class II (HLA-II) peptides using genetic screening.
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