Methods for assessing therapeutic intervention success, health and longevity

By isolating and analyzing extracellular vesicles for specific biomarkers, the method addresses the challenge of monitoring molecular health benefits and intervention efficacy, offering a precise and predictive assessment of longevity and health outcomes.

WO2026107494A1PCT designated stage Publication Date: 2026-05-21DUKE UNIV
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
DUKE UNIV
Filing Date
2025-11-18
Publication Date
2026-05-21

AI Technical Summary

Technical Problem

Current methods lack the ability to effectively monitor exercise-induced health benefits at the molecular level and personalize therapeutic interventions for longevity and overall health, particularly through the use of extracellular vesicles as biomarkers.

Method used

Isolate extracellular vesicles from plasma samples, analyze them for specific biomarkers such as peptides and proteins, and compare their levels to control levels to assess longevity or overall health, and evaluate the efficacy of therapeutic interventions by comparing pre- and post-intervention biomarker levels.

Benefits of technology

Provides a minimally invasive method for assessing longevity and overall health, predicting survival, and evaluating therapeutic intervention efficacy using extracellular vesicle biomarkers, achieving high predictive accuracy and enabling personalized treatment approaches.

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Abstract

The present invention provides methods for assessing longevity or overall health of a subject, and methods for assessing the efficacy of a therapeutic intervention in a subject. The methods comprise isolating extracellular vesicles from a subject and analyzing the extracellular vesicles to determine levels of a plurality of biomarkers. The biomarkers may be used to design personalized treatments and interventions and determine the effectiveness of such interventions.
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