Sulfated archaeosomes as mucosal vaccine adjuvants

Abstract

Provided is an adjuvant for mucosal vaccines comprising a sulfated archeosome comprising a sulfated lactosyl archaeol. The glycoarchaeol may be present as a pharmaceutically acceptable salt. The adjuvant may be comprised together with an antigen in a vaccine composition, which may be for use to induce an immune response in a subject, in particular an antigen-specific mucosal immune response. The vaccine composition may further elicit an immune response that also comprises a cell-mediated response and / or a humoral response.

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