Scalable fixed bed bioreactor platform for cell culture with process and performance scalability

Abstract

Scalable bioreactor platforms and methods of scaling cell cultures are provided that are scalability in bioreactor platform, process, and performance. The bioreactor platform can include a first bioreactor system having a first bioreactor containing a first fixed-bed substrate for adhering cells thereto, and a second bioreactor system having a second bioreactor containing a second fixed-bed substrate for adhering cells thereto. The first fixed-bed substrate has a first surface area, and the second fixed-bed substrate has a second surface area that is larger than the first surface. One or more controllers operating the first and second bioreactor systems control a process variable in the second bioreactor system at a value that is determined by multiplying the value used in the first bioreactor system by a scaling factor N, where N is equal to the second surface area (m2) divided by the first surface area (m2).

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