Compositions and methods for treating cancer by manipulating histone gene expression

WO2026117520A1PCT designated stage Publication Date: 2026-06-04FRED HUTCHINSON CANCER CENT
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
FRED HUTCHINSON CANCER CENT
Filing Date
2025-11-25
Publication Date
2026-06-04

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Abstract

Methods of modulating the level of histone H4 in a target cell. Additionally, methods of treating hyperproliferative disorders using a histone H4 polypeptide or a mutant or variant thereof, a nucleic acid encoding the histone H4, or the mutant or variant nucleic acid thereof and compositions thereof.
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