Fluorescence imaging method and apparatus based on light-source spectral filtering, and storage medium

By combining notch filters and bandpass filters in the light source filtering method, the problem of contrast interference of riboflavin-excited green fluorescence in bladder PDD imaging was solved, realizing high-contrast imaging in PDD fluorescence mode and color reproduction in white light mode.

WO2026124674A1PCT designated stage Publication Date: 2026-06-18ASIERIS PHARMA (SHANGHAI) CO LTD +1
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
ASIERIS PHARMA (SHANGHAI) CO LTD
Filing Date
2025-12-15
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

During bladder PDD imaging, urinary metabolite riboflavin is excited by excitation light and emits green fluorescence, interfering with the contrast of PDD fluorescence. At the same time, changing the excitation light band will lead to a decrease in the fluorescence excitation efficiency of the photosensitizer, affecting the color reproduction of traditional white light imaging.

⚗Method used

A fluorescence imaging method based on light source pass filtering is adopted, which combines notch filters and bandpass filters to filter or compensate the spectrum of green fluorescence band in PDD fluorescence mode and photodynamic white light imaging mode, respectively, to ensure PDD fluorescence contrast and color reproduction of white light imaging.

🎯Benefits of technology

It effectively reduces the interference of green fluorescence on the fluorescence contrast of PDD, ensures color reproduction of traditional white light imaging, and improves imaging effect.

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Abstract

Provided in the present application are a fluorescence imaging method and apparatus based on light-source spectral filtering, and a storage medium. The method comprises: in a PDD fluorescence mode, when a blue light source is turned on, after being reflected by an observed tissue, blue light passing through a notch filter to filter out a spectral band of green fluorescence generated by excitation of riboflavin, so as to reduce the interference of green fluorescence with the contrast of PDD fluorescence; and in a photodynamic white-light imaging mode, when a white light source is turned on, white light first passing through a band-pass filter to increase the proportion of the spectral band of green fluorescence with respect to spectral bands of red and blue fluorescence, and then passing through the notch filter to filter out the spectral band of green fluorescence, wherein the difference between the proportion of the spectral band of green fluorescence reduced by the notch filter and the proportion of the spectral band of green fluorescence increased by the band-pass filter is within a preset range. The problem of green fluorescence generated by excitation of riboflavin during PDD fluorescence imaging affecting the contrast in PDD fluorescence imaging is solved, and color reproduction in conventional white-light imaging is also ensured.
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