Amino-alcohol compounds and their use in therapy
Amino-alcohol compounds are developed to disrupt the YAP/TAZ-TEAD complex, addressing the need for Hippo signaling pathway modulators to treat cancers and fibrosis-related diseases by effectively targeting the complex.
WO2026125505A1PCT designated stage Publication Date: 2026-06-18INVENTIVA
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- INVENTIVA
- Filing Date
- 2025-12-10
- Publication Date
- 2026-06-18
AI Technical Summary
Technical Problem
There is a need for modulators of the Hippo signaling pathway to disrupt the YAP/TAZ-TEAD complex, which is involved in organ development and amplification of oncogenic factors in various cancers and fibrosis-related diseases.
Method used
Development of amino-alcohol compounds that modulate the YAP/TAZ-TEAD complex by disrupting its interaction, which are used in pharmaceutical compositions for treating or preventing cancers and fibrosis-related diseases.
Benefits of technology
The compounds effectively target the YAP/TAZ-TEAD complex, providing therapeutic benefits in treating or preventing a range of cancers and fibrosis-related diseases.
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Abstract
The present disclosure relates to compounds of formula (I): (I) wherein A, W, X, Y, Z, R1, R2, R3 , R4 , R5 , R'5 , R6 , R'6 , R7 , R8 and R9 are as defined herein. The compounds of formula (I) are useful as modulators of the Hippo signaling pathway.
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