Extracellular vesicles derived from lactobacillus reuteri strain and use thereof

Extracellular vesicles from Lactobacillus reuteri address radiation-induced gastrointestinal damage by inhibiting apoptosis and reducing reactive oxygen species, effectively protecting the small intestine and improving survival rates.

WO2026134903A1PCT designated stage Publication Date: 2026-06-25PUSAN NAT UNIV IND UNIV COOPERATION FOUND
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
PUSAN NAT UNIV IND UNIV COOPERATION FOUND
Filing Date
2025-12-05
Publication Date
2026-06-25

AI Technical Summary

Technical Problem

Radiation therapy causes significant side effects in the gastrointestinal tract, particularly in the small intestine, including diarrhea, vomiting, and dizziness, due to damage to the villi and increased apoptosis of intestinal cells, which existing therapeutic measures have not adequately addressed.

Method used

The use of extracellular vesicles derived from Lactobacillus reuteri strain as a therapeutic agent to protect the gastrointestinal tract from radiation damage by inhibiting apoptosis and reducing reactive oxygen species.

Benefits of technology

The extracellular vesicles from Lactobacillus reuteri significantly reduce intestinal damage by preventing villi loss, reducing apoptosis, and decreasing reactive oxygen species, thereby improving the survival rate and health of irradiated subjects.

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Abstract

The present invention relates to extracellular vesicles derived from a (Lactobacillus reuteri strain and uses thereof. The extracellular vesicles derived from the Lactobacillus reuteri strain exhibit protective effects against irradiation, inhibit cell death, prevent or alleviate intestinal damage, and significantly reduce reactive oxygen species, and thus are provided as a composition for preventing, treating or alleviating intestinal damage caused by irradiation.
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