Artificial ventilated lung exposure system and methods
The artificial ventilated lung exposure system addresses the challenge of simulating human lung inhalation by integrating anatomical and physiological features, enabling accurate exposure and toxicity analysis through controlled environmental conditions and dynamic breathing simulations.
WO2026136311A2PCT designated stage Publication Date: 2026-06-25RGT UNIV OF CALIFORNIA
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- RGT UNIV OF CALIFORNIA
- Filing Date
- 2025-12-16
- Publication Date
- 2026-06-25
AI Technical Summary
Technical Problem
Current methods fail to accurately simulate and assess human lung inhalation exposures due to the lack of realistic in vitro models that replicate lung anatomy, physiology, and environmental conditions, leading to inadequate representation of exposure risks and toxicity patterns.
Method used
An artificial ventilated lung exposure system that integrates an airtight chamber reproducing human lung anatomy, simulates breathing dynamics, and controls environmental factors like temperature and humidity, with integrated access ports for monitoring and cell/tissue exposure.
Benefits of technology
Enables accurate assessment of intrapulmonary aerosol exposures and pulmonary biologic responses by simulating regional lung conditions, allowing for precise exposure and toxicity analysis.
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Smart Images
Figure US2025059774_25062026_PF_FP_ABST
Abstract
An artificial ventilated lung exposure system is described. The system is designed to both simulate and assess modeled human lung inhalation exposures by integrating a minimum of three (3) key functional components that include; 1) An airtight lung exposure chamber that reproduces human lung anatomy in terms of lung shape, specified lung volumes, and the presence of modeled airway structures through which air flows in and out of the exposure chamber; 2) A simulation of the dynamic processes involved in breathing that includes, but is not limited to, a) an inhalation phase that delivers a set volume to the lung exposure chamber; b) an exhalation phase that eliminates a set volume from the lung exposure chamber; and c) a control mechanism for adjusting the delivered volumes, respiratory rates and patterns; and 3) Mechanisms for environmental control that include, but are not limited to, control of temperature, relative humidity, intra-chamber gas composition and volume-associated pressure changes (compliance) within the lung exposure chamber.
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