CD70-targeted cars and engineered cells comprising same and related methods
WO2026136848A3PCT designated stage Publication Date: 2026-07-23JUNO THERAPEUTICS INC
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- JUNO THERAPEUTICS INC
- Filing Date
- 2025-12-19
- Publication Date
- 2026-07-23
AI Technical Summary
Technical Problem
Current CAR T cell therapies require patient-specific manufacturing for autologous delivery and face issues with persistence in subjects, leading to high relapse rates, especially in allogeneic administration.
Method used
Development of CD70-targeted chimeric antigen receptors (CARs) with specific VHH regions and genetic modifications to reduce host immune recognition, combined with genetic disruptions to minimize TCR alpha chain and HLA class I expression, and the use of a single chain HLA-E fusion protein to engineer T cells for allogeneic cell therapy.
Benefits of technology
Enhances the persistence and efficacy of CAR T cells by reducing immune recognition and fratricide, allowing for effective allogeneic administration with reduced relapse rates.
✦ Generated by Eureka AI based on patent content.
Abstract
Provided herein are CD70-targeted chimeric antigen receptors (CARs), genetically engineered cells such as T cells containing the same, and related methods and uses of the genetically engineered cells in allogeneic cell therapy. Also provided are T cells that are genetically engineered with a CAR, such as a CD70-targeted CAR, and are further genetically engineered by one or more strategies to reduce host immune recognition of the engineered T cells, such as by heterologous expression of one or more additional transgenes and by genetic disruption to reduce or eliminate expression or one or more endogenous protein. Also provided are methods of making and using the engineered T cells for cell therapy, including in connection with cancer immunotherapy comprising adoptive transfer of the engineered T cells.
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