Composition having hypotonic formulation, and use thereof

Abstract

A sports nutrition food composition having a hypotonic formulation, and a use thereof. The composition comprises one or more of component I, component II, or component III, wherein component I is cyclodextrin or a derivative thereof, component II is a mineral-element-providing compound salt or a mineral-containing extract, and component III is a food excipient; and component I, component II, and component III are in a mass ratio of (10-100):(0-50):(0-20). The composition is a low‑osmolarity formulation composition, and has the effect of significantly facilitating water absorption in the body, facilitates quick water replenishment to protect the body from dehydration, reduces fatigue during exercise, alleviates exercise-related injuries, increases endurance, and promotes bodily recovery.

Description

A composition with low permeability and its application Technical Field

[0001] This invention belongs to the field of sports nutrition food technology, and more specifically, relates to a low-osmolarity formulation composition and its application. Background Technology

[0002] With the accelerated pace of modern life and rising living standards, consumers are increasingly focusing on how functional beverages enhance their quality of life and satisfaction. Their demand for functional beverages is also upgrading from lower-end to higher-quality options. Consumers are paying more attention to factors such as beverage quality, health benefits, and taste. Functional beverages with certain nutritional value or health attributes will occupy a larger share of the future beverage market. In my country, functional beverages are mainly subdivided into seven categories: polysaccharide beverages, vitamin beverages, mineral beverages, sports drinks, probiotic beverages, immune-boosting beverages, and low-energy beverages.

[0003] Sports drinks are beverages specifically designed to replenish energy, fluids, and electrolytes, aiming to help athletes and those engaged in high-intensity physical activity maintain their physical condition and improve athletic performance. Sports drinks typically contain a specific ratio of carbohydrates, electrolytes (such as sodium, potassium, and magnesium), vitamins, and other nutrients to meet the body's energy needs and reduce fluid loss during exercise.

[0004] Despite the rapid growth of the sports drink market in recent years, it also faces some drawbacks and challenges. For example, many traditional sports drinks contain high levels of sugar, which may lead to excessive sugar intake and increase the risk of chronic diseases such as obesity and diabetes. Other sports drinks, while providing energy and hydration, are nutritionally unbalanced and lack sufficient vitamins, minerals, and other nutrients.

[0005] Water is an essential component of cells and body fluids, participating in metabolism and playing roles in regulating body temperature, lubricating joints and intestines. Losing just 10% of the body's water can severely disrupt physiological functions; losing 20% ​​can lead to rapid death. Besides water, the human body's water also contains common minerals such as calcium, magnesium, potassium, and sodium.

[0006] Strenuous exercise, prolonged exercise, and working in consistently high-temperature environments all lead to fluid loss, which is associated with increased sweating. Even a small loss of about 2% of body weight in water can impair exercise endurance and negatively impact cognitive function and recovery. Excessive sweating results in electrolyte loss and reduced fluid volume, leading to physiological stress and a greater increase in the body's heat load. To counteract the adverse effects of dehydration on cardiovascular function and athletic performance, it is now widely recommended to drink beverages rich in carbohydrates and electrolytes to provide the carbohydrates needed for energy, replenish fluids to alleviate dehydration, and counteract hyponatremia.

[0007] During exercise and work under dehydration conditions, anaerobic glucose metabolism and the contribution of liver glycogen to energy production increase. Therefore, to ensure the ability to perform prolonged exercise and work in high-temperature environments, hydration must consider not only the rate of fluid loss but also the increase in carbohydrate utilization. Hydration is related to the body's total water volume. This is an aspect of fluid regulation, involving homeostasis, composition, and the distribution of body fluid volume. Adequate hydration prevents weakness and even reduces oxidative stress, a characteristic of high-intensity exercise such as endurance sports.

[0008] Some people may mistakenly believe that sports drinks can completely replace water, neglecting the importance of pure water and leading to insufficient water intake. Furthermore, the high sugar content in sports drinks may slow down water absorption, making them less effective at replenishing the body's fluids than pure water.

[0009] In summary, functional sports drinks have some drawbacks and limitations in terms of hydration, making it crucial to provide a product containing high-quality dietary fiber and efficient hydration. This invention employs a low-osmotic-pressure hydration and energy supply strategy using dietary fiber-derived carbohydrates plus mineral salts or extracts containing mineral elements. This significantly promotes efficient water absorption, protects the body from dehydration, and provides energy. Summary of the Invention

[0010] The purpose of this invention is to solve the problems existing in the current products and to provide a low-permeability formulation and its application.

[0011] One objective of this invention is to provide a hypotonic composition that, while efficiently replenishing dietary fiber and carbohydrates for energy, reduces the risk of obesity and chronic diseases such as diabetes caused by excessive sugar intake. Simultaneously, this composition enhances hydration, improves water absorption efficiency, and promotes rapid fluid replenishment, making it particularly suitable for rapid recovery of body fluids and electrolyte balance after strenuous exercise, prolonged physical activity, working in high-temperature environments, or post-operative procedures. Furthermore, this composition can supplement minerals, vitamins, and other nutrients to meet daily nutritional needs.

[0012] The second objective of this invention is to provide applications of the composition, specifically relating to its application in regulating the rapid absorption of water and electrolyte balance in the human body during strenuous exercise, prolonged exercise, working in high-temperature environments, or after surgery.

[0013] The objective of this invention and the technical problem it solves are achieved by the following technical solutions.

[0014] One aspect of the present invention provides a composition of a hypotonic formulation, the composition comprising one or more of component I, component II, and component III; wherein component I is cyclodextrin or its derivative, component II is a compound salt providing a mineral element or an extract containing a mineral element, and component III is an edible excipient; the mass ratio of component I, component II, and component III is (10~100):(0~50):(0~20).

[0015] In some preferred embodiments of the present invention, component I is selected from one or more of the following group, which consists of: cyclic dextrin, acetylated cyclic dextrin, phosphorylated cyclic dextrin, carboxymethyl cyclic dextrin, sulfated cyclic dextrin, aminated cyclic dextrin, and similar cyclic dextrin polymers obtained by polymerization reaction.

[0016] In some preferred embodiments of the present invention, component I is selected from one or more of the following group, which consists of: α-cyclic dextrin, acetylated α-cyclic dextrin, phosphorylated α-cyclic dextrin, carboxymethyl α-cyclic dextrin, sulfated α-cyclic dextrin, aminated α-cyclic dextrin, and similar α-cyclic dextrin polymers obtained by polymerization reaction.

[0017] Cyclodextrins are a class of cyclic oligosaccharides composed of multiple glucose units linked by α-1,4 glycosidic bonds. Based on the number of glucose units in the ring, cyclodextrins are mainly classified into three types: α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. Cyclodextrins are a promising natural polysaccharide with broad applications. Due to their unique inclusion ability and good biocompatibility, they have become important functional components in many fields. As a high-quality carbohydrate source, α-cyclodextrin can prevent the absorption of sugars in the intestine, promote the excretion of encapsulated sugars, and reduce the blood glucose peak after a high-starch diet, thus inhibiting postprandial blood glucose rise. Simultaneously, as a source of dietary fiber, due to its special cyclic structure, gastrointestinal enzymes cannot act on the glycosidic bonds of α-cyclodextrin; that is, α-cyclodextrin cannot be digested by the gastrointestinal tract. Orally ingested α-cyclodextrin is completely absorbed in the small intestine at a very low level (approximately 1%) and rapidly excreted in the urine. The remaining α-cyclodextrins, after reaching the colonization site of the large intestine, can be fermented by the intestinal flora to produce beneficial short-chain fatty acids and other products, which are then absorbed by the large intestine.

[0018] In addition, α-cyclodextrin supplementation can also regulate the intestinal flora. Taking a small dose of α-cyclodextrin daily can significantly increase the number of beneficial bacteria such as Bacteroides, Lactobacillus and Bifidobacterium in the intestine, and improve the intestinal ecological balance.

[0019] In some preferred embodiments of the present invention, the mineral elements of component II are selected from one or more of the following group, which consists of: sodium, potassium, calcium, magnesium, zinc, manganese, chromium, phosphorus, sulfur, ferric chloride, copper, iodine, molybdenum, cobalt, tin, vanadium, silicon, nickel, fluorine, selenium, strontium, lithium, iodine, and chlorine.

[0020] In some preferred embodiments of the present invention, the mineral element of component II is selected from the reaction products of one or more compounds in the group consisting of: hydrochloric acid, sulfuric acid, iodine, citric acid, glucose, pyridinecarboxylic acid, fumaric acid, acetic acid, lactic acid, phosphoric acid, glycerophosphate, succinic acid, pyrophosphate, palmitic acid, oxalic acid, dairy products, legumes, nuts, fish, whole grains, and vegetables.

[0021] In some preferred embodiments of the present invention, the mineral elements of component II are derived from the reaction products of trace elements with sugars or acids and their hydrates or derivatives, or from extracts of plants, animals, algae, or microorganisms, and are selected from one or more of the following: seaweed calcium, calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, calcium sulfate, L-calcium lactate, calcium glycerophosphate, calcium citrate-malate, calcium carbonate, calcium fructose borate, magnesium carbonate, magnesium sulfate, magnesium oxide, magnesium chloride, and L-threonic acid. Magnesium, magnesium gluconate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride, potassium citrate, potassium carbonate, potassium gluconate, manganese sulfate, manganese gluconate, ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate, ferrous succinate, ferric pyrophosphate, ferric citrate, sodium ferrous citrate, zinc sulfate, zinc citrate, zinc citrate (trihydrate), zinc gluconate, zinc oxide, zinc lactate, zinc acetate, zinc chloride, sodium selenite, copper sulfate, copper gluconate, sodium L-ascorbate, calcium L-ascorbate, calcium D-pantothenate, sodium D-pantothenate, vitamin E calcium succinate.

[0022] Supplementing with minerals is crucial for maintaining good health and promoting normal physiological functions. Minerals are essential nutrients for the human body. Although required in small amounts, they play a vital role in maintaining health and normal physiological functions. For example, they contribute to maintaining electrolyte balance, bone health, heart health, regulating metabolism, the immune system, nerve conduction and muscle function, and fluid balance. Common minerals can be obtained from a variety of food sources. For instance, calcium is primarily found in dairy products, legumes, nuts, leafy green vegetables, and fish; magnesium in nuts and seeds, whole grains, legumes, and leafy green vegetables; potassium in fruits, vegetables, legumes, and nuts; iron in red meat, poultry, seafood, legumes, whole grains, and leafy green vegetables; zinc in meat, seafood, nuts, legumes, and whole grains; iodine in seafood, iodized salt, milk, and eggs; and selenium in seafood, nuts, meat, mushrooms, and whole grains. We can effectively obtain minerals through these common minerals and their food sources, and maintain our health and normal physiological functions through a diverse diet. However, due to various reasons such as unbalanced diet, digestive system problems, growth and development, chronic diseases, medication effects, dietary habits, and environmental factors, mineral deficiency is also very common in the human body.

[0023] In some preferred embodiments of the present invention, component III is a commonly used excipient in food processing, including but not limited to sweeteners, acidulants, or conventional nutrient supplements such as B vitamins and vitamin K2. However, this component is not entirely necessary and has no substantial impact on the efficacy of the composition of the present invention.

[0024] Short-term strenuous exercise, prolonged exercise, and physical activity in high ambient temperature and humidity can all impair thermoregulation, leading to severe dehydration and significant stress on muscles due to both endogenous and exogenous hyperthermia. Exercise- and environmentally-induced muscle fiber damage can trigger an inflammatory response associated with elevated levels of blood myoglobin, creatine kinase, and lactate dehydrogenase. These proteins are widely used indicators of skeletal muscle injury. Furthermore, post-exercise muscle damage can induce an inflammatory response associated with increased levels of certain pro-inflammatory interleukins, thereby stimulating the production of C-reactive protein in the liver. Interleukins are a large class of polypeptides called cytokines that are directly associated with inflammation related to the infiltration of neutrophils and later macrophages into the site of injury. Increased production of reactive oxygen species due to strenuous exercise, dehydration, and hyperthermia further contributes to an oxidative-antioxidant imbalance.

[0025] Conventional sports hydration drinks are generally isotonic, primarily because their osmotic pressure is similar to that of the body. However, the inventors of this application have discovered a hydration strategy employing special dietary fiber and mineral salts with low osmotic pressure, which is more conducive to hydration and promotes efficient water absorption by the body. Simultaneously, dietary fiber can also avoid the risks of obesity and chronic diseases such as diabetes associated with sugar intake.

[0026] In some preferred embodiments of the present invention, when the composition is formulated into a liquid, the mass fraction of component I in the solution ranges from 5% to 30%, preferably from 5% to 20%.

[0027] The method for preparing the low-osmotic formulation of the present invention is to weigh each component in the formulation composition according to the stated proportion, mix them evenly, and granulate them by wet or dry methods to obtain the composition.

[0028] A second aspect of the present invention provides a product for rapid replenishment of water with low osmotic pressure, comprising the aforementioned composition, or a downstream product prepared using the composition.

[0029] In some preferred embodiments of the present invention, the product may be in the form of powder, granules, liquid, or semi-solid, preferably in liquid form.

[0030] In some preferred embodiments of the present invention, the product is in the form of sports drinks, beverages containing fruit juice and vegetable juice, plant-based beverages, sparkling water, frozen drinks, oral liquids, oral hydration tablets / powders, or gel-like hydration products.

[0031] In some preferred embodiments of the present invention, when the final product is in liquid form, the osmotic pressure of the product is between 10 mOsmol / L and 275 mOsmol / L, preferably between 50 mOsmol / L and 275 mOsmol / L.

[0032] In some preferred embodiments of the present invention, when the final product is in liquid form, the sodium ion concentration in the product is between 10 mg / L and 150 mg / L, preferably between 10 mg / L and 100 mg / L.

[0033] A third aspect of the invention provides the use of a hypotonic beverage composition in the preparation of a product with low osmotic pressure and rapid hydration.

[0034] By employing the above technical solution, the present invention has at least the following advantages:

[0035] 1) The low-osmotic-pressure hydration composition of high-quality carbohydrates plus mineral salts or trace elements from natural sources of the present invention can improve the body's biological impedance, enhance the body's hydration, enable water transport across the cell membrane, and promote the rapid replenishment of water in the body. It is especially suitable for scenarios where the body needs to restore water and electrolyte balance after strenuous exercise, long-term exercise, working in high-temperature environments, or surgery.

[0036] 2) The composition of the present invention provides energy by supplementing high-quality carbohydrates, while reducing the risk of chronic diseases such as obesity and diabetes caused by excessive sugar intake.

[0037] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, the preferred embodiments of the present invention are described in detail below. Attached Figure Description

[0038] Figure 1 shows the trend of cumulative urine volume after drinking different beverages;

[0039] Figure 2 shows the BHI index of different beverages. Detailed Implementation

[0040] To make the technical means, creative features, achieved objectives, and effects of this invention readily understandable, the technical solutions in the embodiments of this invention will be clearly and completely described below in conjunction with the embodiments of this invention. Obviously, the described embodiments are merely some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0041] This invention provides a low-osmotic composition that employs a low-osmotic-pressure hydration strategy using dietary fiber-derived carbohydrates and mineral salts. This improves the body's bioresistance, enhances hydration, and facilitates water transport across cell membranes, promoting rapid and efficient hydration. It is particularly suitable for rapid restoration of body fluids and electrolyte balance after strenuous exercise, prolonged physical activity, working in high-temperature environments, or post-surgery. Simultaneously, supplementing with high-quality carbohydrates from dietary fiber as an energy source reduces the risk of obesity and chronic diseases such as diabetes caused by excessive sugar intake. Another objective of this invention is to provide the application of the composition in situations involving strenuous exercise, prolonged physical activity, working in high-temperature environments, or post-surgery, addressing the issue of efficient and rapid hydration.

[0042] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0043] Unless otherwise specified, all materials and reagents used in the following examples are commercially available.

[0044] In the quantitative experiments described below, three replicate experiments were conducted, and the average value was taken as the result.

[0045] Example 1: This example provides a hypotonic formulation composition and a beverage prepared according to the composition, as detailed below:

[0046] According to the mass percentage ratio, the composition and content of this composition are as follows: α-cyclodextrin 15.87%, calcium citrate 2.27%, potassium citrate 79.34%, magnesium sulfate 0.4%, sodium chloride 2.02%, and zinc sulfate 0.11%.

[0047] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0048] Accurately weigh 25.2 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0049] Example 2: This example provides a hypotonic formulation composition and a beverage prepared according to the composition, as detailed below:

[0050] According to the mass percentage ratio, the composition and content of the composition are as follows: α-cyclodextrin 13.74%, calcium citrate 2.75%, potassium citrate 82.42%, magnesium sulfate 0.33%, sodium chloride 0.69%, and zinc sulfate 0.08%.

[0051] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0052] Accurately weigh 36.4 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0053] Example 3: This example provides a hypotonic formulation composition and a beverage prepared according to the composition, as detailed below:

[0054] According to the mass percentage ratio, the composition and content of this composition are as follows: α-cyclodextrin 8.11%, calcium citrate 2.57%, potassium citrate 88.9%, magnesium sulfate 0.2%, sodium chloride 0.17%, and zinc sulfate 0.05%.

[0055] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0056] Accurately weigh 74 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0057] Example 4: This example provides a hypotonic formulation composition and a beverage prepared according to the composition, as detailed below:

[0058] According to the mass percentage ratio, the composition and content of this composition are as follows: α-cyclodextrin 40.87%, calcium lactate 26.8%, potassium chloride 19.54%, magnesium sulfate 6.13%, sodium chloride 5.2%, and zinc sulfate 1.46%.

[0059] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0060] Accurately weigh 2.45 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0061] Example 5: This example provides a hypotonic formulation composition and a beverage prepared according to the composition, as detailed below:

[0062] According to the mass percentage ratio, the composition and content of this composition are as follows: α-cyclodextrin 40.87%, calcium lactate 26.8%, potassium chloride 19.54%, magnesium sulfate 6.13%, sodium chloride 5.2%, and zinc sulfate 1.46%.

[0063] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0064] Accurately weigh 4.89 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0065] Comparative Example 1: This comparative example provides a hypotonic formulation composition and a beverage prepared according to the composition, as follows:

[0066] According to the mass percentage ratio, the composition and content of this composition are: 100% α-cyclodextrin.

[0067] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0068] Accurately weigh 6 parts of α-cyclodextrin, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0069] Comparative Example 2: This comparative example provides a hypotonic formulation composition and a beverage prepared according to the composition, as follows:

[0070] According to the mass percentage ratio, the composition and content of this composition are as follows: calcium citrate 2.57%, potassium citrate 88.9%, magnesium sulfate 0.2%, sodium chloride 0.17%, and zinc sulfate 0.05%.

[0071] A method for preparing a low-osmotic-pressure beverage includes the following steps:

[0072] Accurately measure 68 parts of the above composition, use deionized water to measure to 100 parts, stir and mix evenly to obtain a low osmotic pressure beverage.

[0073] Experimental Example 1: The Effects of Different Beverages on Hydration

[0074] Prepare beverages with different ingredients according to the recipes in Table 1.

[0075] Table 1 Beverage Formulas and Contents

[0076]

[0077] The preparation methods for the above-mentioned beverages are as follows:

[0078] According to the numbering order in Table 1, measure 1000 mL of purified water, heat to boiling, maintain for 3 minutes, and slowly add the corresponding mass percentage of the low-osmotic formulation composition of the corresponding embodiment. After mixing evenly, cool to room temperature, package and store to obtain beverages, which are numbered 1 to 7 respectively.

[0079] Seventy-two volunteers were recruited and randomly divided into nine groups of eight. The inclusion criteria for volunteers were as follows: age 18-40 years and general health. The following conditions disqualified volunteers: history of cardiovascular, renal, musculoskeletal, or metabolic diseases; history of urinary incontinence or urinary frequency; presence of a pacemaker or other implanted electrical device; history of hand or foot amputation; or current pregnancy.

[0080] All participants refrained from eating, drinking alcohol, or taking nicotine or other medications for at least 8 hours prior to the test, and from exercising or engaging in strenuous physical activity for at least 24 hours prior to the test. Before the test, volunteers were asked to drink 500 ml of purified water within 15 minutes. Upon arrival at the laboratory, volunteers sat quietly in a comfortable environment for 10 minutes. Participants were then asked to empty their bladders. Participants ingested 1 liter of test sample over 30 minutes (an average of 250 mL every 7.5 minutes). Urine was collected over the following 4 hours, and naked weight was also measured at the end of the test. The osmolality of all ingested samples was measured using a BS-100Y freezing point osmoremeter (results are shown in Table 2). To assess the practical significance of the observed differences in BHI between the blank and each test sample, the differences were compared with the normal variation identified through separate repeatability analyses. For this purpose, participants ingested the same beverages in both cases for this repeatability analysis. Test samples included purified water, a sports drink, and beverages 1–7. Results are shown in Figures 1 and 2.

[0081] Table 2 Osmotic pressure of test samples

[0082]

[0083] The Beverage Hydration Index (BHI) is calculated by dividing the mass of urine excreted within two hours after consuming one liter of purified water (i.e., the control condition) by the mass of urine excreted within two hours after consuming the formulated beverage.

[0084] Figure 1 shows the cumulative urine volume trend after ingestion of the test samples. Examples 1-5 and Comparative Examples 1-2 refer to beverages 1-7 prepared in the corresponding examples and comparative examples. As can be seen from Figure 1, there was no significant difference in urine quality in the experiment conducted immediately after drinking the test samples. Compared to purified water, the effect size of the cumulative urine volume over 4 hours was significantly lower in the beverages prepared with the compositions of Examples 1-5 than in the beverages prepared with the compositions of Comparative Examples 1-2 and the positive control, the pulsating beverage. Although beverages 6-7 had low osmotic pressure, no significant difference in cumulative urine volume was observed compared to the examples.

[0085] Figure 2 shows the BHI (Body Hydration Index) trend chart. Examples 1-5 and Comparative Examples 1-2 refer to beverages 1-7 prepared in the corresponding examples and comparative examples. As can be seen from the figure, compared with purified water, the beverages prepared with the compositions of Examples 1-5 have a significantly higher BHI than the beverages prepared with the compositions of Comparative Examples 1-2 and the positive control, the Pulse beverage. Furthermore, the beverage prepared with the composition of Example 3 has the best hydration effect.

[0086] Based on the osmotic pressure data in Table 2, it is evident that the beverages prepared using the compositions of Examples 1-5 exhibit better cumulative urine volume and hydration index than isotonic and hypertonic beverages. The hydration index indirectly indicates a better water retention effect in the body and a superior hydration function. However, lower osmotic pressure is not necessarily better; excessively low osmotic pressure can negatively impact cumulative urine volume and hydration index.

[0087] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the methods and techniques disclosed above without departing from the scope of the present invention to create equivalent embodiments. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A composition with low permeability formulation, characterized in that, The composition comprises one or more of component I, component II, and component III; wherein, component I is cyclodextrin or a derivative thereof, component II is a compound salt providing a mineral element or an extract containing a mineral, and component III is an edible excipient; the mass ratio of component I, component II, and component III is (10~100):(0~50):(0~20).

2. The composition according to claim 1, characterized in that, Component I is selected from one or more of the following groups: α-cyclodextrin, acetylated α-cyclodextrin, phosphorylated α-cyclodextrin, carboxymethyl α-cyclodextrin, sulfated α-cyclodextrin, aminated α-cyclodextrin, and similar α-cyclodextrin polymers obtained by polymerization.

3. The composition according to claim 1, characterized in that, The mineral elements in component II are selected from one or more of the following group, which consists of: sodium, potassium, calcium, magnesium, zinc, manganese, chromium, phosphorus, sulfur, ferric chloride, copper, iodine, molybdenum, cobalt, tin, vanadium, silicon, nickel, fluorine, selenium, strontium, lithium, iodine, and chlorine.

4. The composition according to claim 1, characterized in that, The mineral element of component II is derived from the reaction products of one or more compounds in the group consisting of: hydrochloric acid, sulfuric acid, iodine, citric acid, glucose, pyridinecarboxylic acid, fumaric acid, acetic acid, lactic acid, phosphoric acid, glycerophosphate, succinic acid, pyrophosphate, palmitic acid, oxalic acid, dairy products, legumes, nuts, fish, whole grains, and vegetables.

5. The composition according to claim 1, characterized in that, The mineral elements in Component II are derived from the reaction products of trace elements with sugars or acids, their hydrates, or derivatives, or from extracts of plants, animals, algae, or microorganisms, and are selected from one or more of the following groups: seaweed calcium, calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, calcium sulfate, L-calcium lactate, calcium glycerophosphate, calcium citrate-malate, calcium carbonate, calcium fructose-borate, magnesium carbonate, magnesium sulfate, magnesium oxide, magnesium chloride, L-threonate magnesium, and gluconate. Magnesium gluconate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride, potassium citrate, potassium carbonate, potassium gluconate, manganese sulfate, manganese gluconate, ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate, ferrous succinate, ferric pyrophosphate, ferric citrate, sodium ferrous citrate, zinc sulfate, zinc citrate, zinc citrate (trihydrate), zinc gluconate, zinc oxide, zinc lactate, zinc acetate, zinc chloride, sodium selenite, copper sulfate, copper gluconate, sodium L-ascorbate, calcium L-ascorbate, calcium D-pantothenate, sodium D-pantothenate, vitamin E calcium succinate.

6. The composition according to claim 1, characterized in that, Component III is selected from sweeteners, acidulants, or nutritional fortifiers.

7. The composition according to claim 1, characterized in that, When the composition is formulated into a liquid, the proportion of component I in the liquid ranges from 5% to 20%.

8. A product for rapid hydration with low osmotic pressure, characterized in that, The composition comprising any one of claims 1-7.

9. The product according to claim 8, characterized in that, The product is in liquid form, and its osmotic pressure is between 50 mOsmol / L and 275 mOsmol / L; the sodium ion concentration in the product is between 10 mg / L and 100 mg / L.

10. The application of a hypotonic formulation composition in the preparation of a product with low osmotic pressure and rapid hydration, characterized in that, The composition is the composition of any one of claims 1-7, and the product is in the form of sports drinks, beverages containing fruit juice and vegetable juice, plant-based beverages, sparkling water, frozen drinks, oral liquids, oral hydrating tablets / powders, or gel-like hydrating products.

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