Compositions and methods for preparation of biologic knee replacement

A biologic knee replacement using 3D-printed, stem cell-derived tissues addresses the limitations of conventional knee replacements by providing a durable, integrated, and functional alternative with reduced stress and faster recovery.

WO2026143204A1PCT designated stage Publication Date: 2026-07-02THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK +1
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Filing Date
2025-12-24
Publication Date
2026-07-02

AI Technical Summary

Technical Problem

Current total knee replacements have high complication rates, limited lifespan, and require extensive rehabilitation, while biologic alternatives are slow to generate functional cartilage and limited by tissue availability.

Method used

A biologic living total knee arthroplasty device composed of biocompatible and bioresorbable polymers and stem cell-derived tissues, designed using 3D printing and finite element modeling to mimic natural joint mechanics, with distinct cartilage and bone domains for improved integration and functionality.

Benefits of technology

The device provides a durable, biocompatible, and functional knee replacement that reduces stress, promotes tissue integration, and mimics natural joint lubrication, potentially extending lifespan and reducing rehabilitation time.

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Abstract

The present disclosure provides compositions and methods for preparation of a novel patient-specific entirely biologic living total knee arthroplasty (TKA) / joint replacement.
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