Microfluidics devices for rapid and high-throughput immune complex imaging and epitope mapping
Microfluidic devices with engineered streptavidin molecules facilitate rapid and high-throughput isolation and imaging of immune complexes, overcoming the limitations of conventional methods by enabling efficient epitope mapping with minimal sample volumes.
WO2026151597A1PCT designated stage Publication Date: 2026-07-16THE SCRIPPS RES INST
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- THE SCRIPPS RES INST
- Filing Date
- 2025-12-19
- Publication Date
- 2026-07-16
AI Technical Summary
Technical Problem
Conventional methods for identifying molecular interactions between antibodies and viral pathogens are laborious, time-consuming, and require large sample volumes, limiting their application to biobanks and preclinical studies, and often underestimate epitopes targeted.
Method used
Microfluidic devices with biocompatible polymers and engineered streptavidin molecules for rapid and high-throughput isolation and imaging of immune complexes, using minimal sample volumes and combining with electron microscopy for structural characterization.
Benefits of technology
Enables rapid, high-throughput mapping of immune complexes, detecting a greater number of epitopes and requiring minimal sample volumes, suitable for large-scale clinical studies and preclinical vaccine design.
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Abstract
The present invention provides microfluidics devices and related methods for rapid and high-throughput immune complex imaging and epitope mapping.
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