Compositions and methods for manipulating the developmental fate of a cell

Lipid nanoparticle compositions encapsulating nucleic acids facilitate rapid and efficient cell fate conversion, overcoming inefficiencies and risks of existing methods, producing high yields of specialized cells.

WO2026152238A1PCT designated stage Publication Date: 2026-07-23STEMCELL TECHNOLOGIES CANADA INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
STEMCELL TECHNOLOGIES CANADA INC
Filing Date
2026-01-20
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Existing methods for converting the developmental fate of a cell are lengthy, costly, inefficient, and yield variable outcomes, and integration of nucleic acids carries risks such as insertional mutagenesis and viral safety concerns.

Method used

Compositions comprising lipid nanoparticles encapsulating nucleic acid molecules are used to contact cells, allowing for rapid and efficient conversion of cell fate without integration, using specific dosing regimens and culture media to induce derivative cells.

Benefits of technology

The method achieves rapid, efficient, and integration-free conversion of cell fate, producing high yields of specialized derivative cells with consistent outcomes.

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Abstract

This disclosure relates to compositions and methods for altering or influencing the development of cells. Compositions of this disclosure comprise lipid nanoparticles formulated with nucleic acid molecule(s), which nucleic acid molecule(s) when introduced / delivered into a cell or a population of cells exert their function to alter or influence a developmental trajectory of such recipient cell(s). Nucleic acid molecule(s) as comprised in compositions of this disclosure may encode transcriptional regulatory proteins, such as transcription factors.
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