Medical organic gel material and method for preparing same

Abstract

The present invention relates to the field of medical material technology, and particularly relates to a medical organic gel material and a method for preparing same. The medical organic gel material is prepared from the following components: chitosan, gelatin, sodium alginate, sodium carboxymethyl cellulose, β-glucan, a composite nano-additive, and water. The medical organic gel material prepared by the present invention has excellent antimicrobial performance and good liquid absorption performance, and can be applied to medical settings. By introducing the composite nano-additive into the raw material components, the present invention can not only slightly improve the liquid absorption performance of the organic gel, but also greatly improve the antimicrobial performance of the organic gel material. The organic gel material prepared by the present invention can be used as a carrier of a drug delivery system, and can achieve the slow release and high stability of drugs. This is mainly based on the treatment with a specific alternating electric field performed in the preparation process, which greatly changes the structure of the organic gel material and provides the organic gel material with higher stability and slow drug release performance.

Description

A medical organogel material and its preparation method Technical Field

[0001] This invention relates to the field of medical materials technology, specifically to a medical organic gel material and its preparation method. Background Technology

[0002] Current medical wound dressings are usually made of gauze or non-woven fabric and cotton with medication. They can protect wounds from mechanical damage and prevent infection, but their antibacterial, absorbent, and anti-inflammatory properties cannot adequately meet market demands.

[0003] Medical organic gel materials have a wide range of applications in the medical field. They typically possess good biocompatibility, biodegradability, and specific physical and chemical properties, enabling them to meet various needs in medical procedures.

[0004] Medical organic gel materials are gel-like substances made of organic molecules, exhibiting a viscous liquid state. Depending on the preparation method and composition, medical organic gels can be classified into various types, such as natural polymer gels (e.g., gelatin, chitosan), synthetic polymer gels (e.g., polyvinyl alcohol, polyurethane), and organosilicon gels.

[0005] However, the water absorption properties of organic gel materials prepared by existing technologies are relatively average, and their antibacterial properties are insufficient. When used in medicine, they cannot meet the requirements for liquid absorption, and with prolonged use, they are prone to bacterial growth, which can delay wound healing. Summary of the Invention

[0006] To address the problems existing in the prior art, the present invention provides a medical organic gel material and its preparation method.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A medical organic gel material, by weight, comprises the following components: 1-2 parts chitosan, 12-16 parts gelatin, 10-12 parts sodium alginate, 6-8 parts sodium carboxymethyl cellulose, 3-5 parts β-glucan, 1-1.8 parts composite nano-additives, and 100-110 parts water.

[0009] As a further technical solution, the method for preparing the composite nano-additive is as follows:

[0010] First, lignin is added to a grinder and ground for 4 hours, then sieved to obtain preliminary ground material;

[0011] The preliminary grinding material obtained above was added to ethylene glycol and stirred and mixed at room temperature for 30 minutes to obtain an ethylene glycol solution of lignin.

[0012] Add hydrochloric acid solution to the ethylene glycol solution of lignin, adjust the pH to 4.0, adjust the temperature to 45°C, and stir for 2 hours to obtain an intermediate solution;

[0013] The intermediate solution obtained above was dialyzed in deionized water until the pH of the dialysate was neutral. Then the dialysate was freeze-dried to obtain nanoparticles.

[0014] The nanoparticles and silver oxide nanoparticles are then mixed evenly to obtain a composite nano-additive.

[0015] As a further technical solution, the grinding process is as follows:

[0016] The grinding speed of lignin in the grinding mill is 550-600 r / min, and the grinding temperature is 50-55℃.

[0017] As a further technical solution, the lignin concentration in the ethylene glycol solution of lignin is 5-6 wt%.

[0018] The concentration of the hydrochloric acid solution is 0.5 mol / L.

[0019] As a further technical solution, the mass ratio of the nanoparticles to the nano-silver oxide particles is 1:12-15.

[0020] As a further technical solution, the molecular weight of the gelatin is less than 55 kDa.

[0021] A method for preparing a medical organic gel material includes the following steps:

[0022] (1) Add sodium carboxymethyl cellulose, β-glucan and water to a constant temperature magnetic stirrer and stir for 30 min to obtain the first mixture;

[0023] (2) Add chitosan, composite nano additives and the first mixture to a vortex mixer in sequence and mix for 15 minutes to obtain the second mixture.

[0024] (3) Add gelatin, sodium alginate and the second mixture to an ultrasonic cell disruptor for ultrasonic dispersion for 10 min to obtain the third mixture.

[0025] (4) The third mixture is treated in an alternating electric field for 50-60 seconds, then discharged and left to stand for 24 hours to obtain an organic gel material.

[0026] As a further technical solution, the ultrasonic frequency of the ultrasonic dispersion is 40kHz.

[0027] As a further technical solution, the frequency of the alternating electric field is 30-35kHz, and the field strength is 2-2.5kV / cm.

[0028] Compared with the prior art, the beneficial effects of the present invention are:

[0029] The medical organic gel material prepared by this invention has excellent antibacterial properties and high liquid absorption properties, making it suitable for medical applications.

[0030] This invention introduces composite nano-additives into the raw material components, which not only slightly improves the liquid absorption performance of organic gels, but also significantly enhances the antibacterial properties of organic gel materials.

[0031] The organic gel material prepared by this invention has excellent antibacterial properties and can be used as a carrier for drug delivery systems, enabling slow release and stability of drugs, thereby improving the therapeutic effect and reducing side effects. This is mainly based on the specific alternating electric field treatment carried out during the preparation of the organic gel material, which greatly changes the structure of the organic gel material, thus making it more stable and slow to release drugs.

[0032] Because the organic gel material of the present invention has high liquid absorption properties, it can be used for hemostasis, promoting wound healing and preventing infection in wound treatment. The organic gel material of the present invention can rapidly absorb wound exudate, form a protective barrier, reduce bacterial growth, and promote cell regeneration and tissue repair. Detailed Implementation

[0033] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] The following are specific examples:

[0035] Example 1

[0036] A medical organic gel material, by weight, comprises the following components: 1 part chitosan, 12 parts gelatin, 10 parts sodium alginate, 6 parts sodium carboxymethyl cellulose, 3 parts β-glucan, 1 part composite nano-additive, and 100 parts water.

[0037] The preparation method of composite nano-additives is as follows:

[0038] First, lignin is added to a grinder and ground for 4 hours, then sieved to obtain preliminary ground material; the grinding process is as follows:

[0039] The lignin was ground in a grinder at a speed of 550 r / min and a grinding temperature of 50℃.

[0040] The preliminary grinding material obtained above was added to ethylene glycol and stirred and mixed at room temperature for 30 minutes to obtain an ethylene glycol solution of lignin.

[0041] Add hydrochloric acid solution to the ethylene glycol solution of lignin, adjust the pH to 4.0, adjust the temperature to 45°C, and stir for 2 hours to obtain an intermediate solution;

[0042] The intermediate solution obtained above was dialyzed in deionized water until the pH of the dialysate was neutral. Then the dialysate was freeze-dried to obtain nanoparticles.

[0043] The nanoparticles and silver oxide nanoparticles are then mixed evenly to obtain a composite nano-additive.

[0044] The lignin concentration in the ethylene glycol solution of lignin is 5 wt%.

[0045] The concentration of the hydrochloric acid solution is 0.5 mol / L.

[0046] The mass ratio of nanoparticles to nano-silver oxide particles is 1:12.

[0047] Gelatin has a molecular weight of less than 55 kDa.

[0048] Example 2

[0049] A medical organic gel material is made of the following components by weight: 1.6 parts chitosan, 15 parts gelatin, 11 parts sodium alginate, 7 parts sodium carboxymethyl cellulose, 4 parts β-glucan, 1.2 parts composite nano-additives, and 102 parts water.

[0050] The preparation method of composite nano-additives is as follows:

[0051] First, lignin is added to a grinder and ground for 4 hours, then sieved to obtain preliminary ground material; the grinding process is as follows:

[0052] The lignin was ground in a grinder at a speed of 550 r / min and a grinding temperature of 50℃.

[0053] The preliminary grinding material obtained above was added to ethylene glycol and stirred and mixed at room temperature for 30 minutes to obtain an ethylene glycol solution of lignin.

[0054] Add hydrochloric acid solution to the ethylene glycol solution of lignin, adjust the pH to 4.0, adjust the temperature to 45°C, and stir for 2 hours to obtain an intermediate solution;

[0055] The intermediate solution obtained above was dialyzed in deionized water until the pH of the dialysate was neutral. Then the dialysate was freeze-dried to obtain nanoparticles.

[0056] The nanoparticles and silver oxide nanoparticles are then mixed evenly to obtain a composite nano-additive.

[0057] The lignin concentration in the ethylene glycol solution of lignin is 5 wt%.

[0058] The concentration of the hydrochloric acid solution is 0.5 mol / L.

[0059] The mass ratio of nanoparticles to nano-silver oxide particles is 1:12.

[0060] Gelatin has a molecular weight of less than 55 kDa.

[0061] Example 3

[0062] A medical organic gel material is made of the following components by weight: 2 parts chitosan, 16 parts gelatin, 12 parts sodium alginate, 8 parts sodium carboxymethyl cellulose, 5 parts β-glucan, 1.8 parts composite nano-additives, and 110 parts water.

[0063] The preparation method of composite nano-additives is as follows:

[0064] First, lignin is added to a grinder and ground for 4 hours, then sieved to obtain preliminary ground material; the grinding process is as follows:

[0065] The lignin was ground in a grinder at a speed of 550 r / min and a grinding temperature of 50℃.

[0066] The preliminary grinding material obtained above was added to ethylene glycol and stirred and mixed at room temperature for 30 minutes to obtain an ethylene glycol solution of lignin.

[0067] Add hydrochloric acid solution to the ethylene glycol solution of lignin, adjust the pH to 4.0, adjust the temperature to 45°C, and stir for 2 hours to obtain an intermediate solution;

[0068] The intermediate solution obtained above was dialyzed in deionized water until the pH of the dialysate was neutral. Then the dialysate was freeze-dried to obtain nanoparticles.

[0069] The nanoparticles and silver oxide nanoparticles are then mixed evenly to obtain a composite nano-additive.

[0070] The lignin concentration in the ethylene glycol solution of lignin is 5 wt%.

[0071] The concentration of the hydrochloric acid solution is 0.5 mol / L.

[0072] The mass ratio of nanoparticles to nano-silver oxide particles is 1:12.

[0073] Gelatin has a molecular weight of less than 55 kDa.

[0074] The preparation methods in the above embodiments are all:

[0075] A method for preparing a medical organic gel material includes the following steps:

[0076] (1) Add sodium carboxymethyl cellulose, β-glucan and water to a constant temperature magnetic stirrer and stir for 30 min to obtain the first mixture;

[0077] (2) Add chitosan, composite nano additives and the first mixture to a vortex mixer in sequence and mix for 15 minutes to obtain the second mixture.

[0078] (3) Add gelatin, sodium alginate and the second mixture to an ultrasonic cell disruptor in sequence and perform ultrasonic dispersion treatment for 10 min to obtain the third mixture; the ultrasonic dispersion frequency is 40 kHz.

[0079] (4) The third mixture was treated in an alternating electric field for 50 seconds, then discharged and left to stand for 24 hours to obtain an organic gel material; the frequency of the alternating electric field was 30 kHz and the field strength was 2 kV / cm.

[0080] Comparative Example 1: This comparative example is basically the same as Example 1, except that no composite nano additives are added.

[0081] Comparative Example 2:

[0082] This comparative example is basically the same as Example 1, except that no alternating electric field treatment is performed.

[0083] test:

[0084] The medical organic gel materials of the examples and comparative examples were vacuum dried (50°C, 4 hours), and the weights of the examples and comparative examples were recorded after drying. The dried medical organic gel materials of the examples and comparative examples were then soaked in water for 12 hours, and the weight of the gel materials after water absorption was calculated after 12 hours.

[0085] The weight ratios of the gel material after water absorption to its weight before water absorption are shown in Table 1.

[0086] Table 1

[0087] As shown in Table 1, the organic gel material prepared in this invention has higher water absorption performance.

[0088] The organogel materials from the examples and comparative examples were vacuum dried and then cut into 0.001 μm pieces. 3 The blocks were placed in culture media containing bacterial suspensions of *Escherichia coli* and *Staphylococcus aureus* (initial concentration 1×10⁻⁶ for both examples and comparative examples). 6 In a solution of cfu / mL, the bacterial suspension was shaken at 35℃ for 12 hours. The number of colonies in the bacterial suspension was measured, a blank test was set up, and the inhibition rate was calculated. The results are shown in Table 2.

[0089] Table 2

[0090] As can be seen from Table 2, the organic gel material prepared by this invention has excellent antibacterial properties.

[0091] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not describe all details exhaustively, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification.

Claims

1. A medical organic gel material, characterized by, It is made of the following ingredients by weight: 1-2 parts chitosan, 12-16 parts gelatin, 10-12 parts sodium alginate, 6-8 parts sodium carboxymethyl cellulose, 3-5 parts β-glucan, 1-1.8 parts composite nano additives, and 100-110 parts water.

2. The medical organic gel material according to claim 1, wherein The method for preparing the composite nano-additive is as follows: First, lignin is added to a grinder and ground for 4 hours, then sieved to obtain preliminary ground material; The preliminary grinding material obtained above was added to ethylene glycol and stirred and mixed at room temperature for 30 minutes to obtain an ethylene glycol solution of lignin. Add hydrochloric acid solution to the ethylene glycol solution of lignin, adjust the pH to 4.0, adjust the temperature to 45°C, and stir for 2 hours to obtain an intermediate solution; The intermediate solution obtained above was dialyzed in deionized water until the pH of the dialysate was neutral. Then the dialysate was freeze-dried to obtain nanoparticles. The nanoparticles and silver oxide nanoparticles are then mixed evenly to obtain a composite nano-additive.

3. A medical organic gel material according to claim 2, wherein The grinding process is as follows: The grinding speed of lignin in the grinding mill is 550-600 r / min, and the grinding temperature is 50-55℃.

4. The medical organic gel material according to claim 2, wherein The lignin concentration in the ethylene glycol solution of the lignin is 5-6 wt%. The concentration of the hydrochloric acid solution is 0.5 mol / L.

5. The medical organic gel material according to claim 3, wherein The mass ratio of the nanoparticles to the nano-silver oxide particles is 1:12-15.

6. The medical organic gel material according to claim 1, wherein The molecular weight of the gelatin is less than 55 kDa.

7. A method for preparing a medical organic gel material according to any one of claims 1-6, characterized in that, Includes the following steps: (1) Add sodium carboxymethyl cellulose, β-glucan and water to a constant temperature magnetic stirrer and stir for 30 min to obtain the first mixture; (2) Add chitosan, composite nano additives and the first mixture to a vortex mixer in sequence and mix for 15 minutes to obtain the second mixture. (3) Add gelatin, sodium alginate and the second mixture to an ultrasonic cell disruptor for ultrasonic dispersion for 10 min to obtain the third mixture. (4) The third mixture is treated in an alternating electric field for 50-60 seconds, then discharged and left to stand for 24 hours to obtain an organic gel material.

8. The method for preparing a medical organic gel material according to claim 7, characterized in that, The ultrasonic dispersion frequency is 40 kHz.

9. The method for preparing a medical organic gel material according to claim 7, characterized in that, The frequency of the alternating electric field is 30-35kHz, and the field strength is 2-2.5kV / cm.

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