Pharmaceutical composition comprising dual agonist, preparation method, and pharmaceutical use of pharmaceutical composition

By optimizing the antibacterial agents, osmotic pressure regulators, buffers, and pH adjusters in the GIP/GLP-1 dual receptor agonist composition, the stability and antibacterial properties of the liquid formulation were resolved, ensuring the efficacy and safety of the drug and making it suitable for human injection administration.

WO2026153411A1PCT designated stage Publication Date: 2026-07-23JIANGSU HANSOH PHARMA CO LTD +1
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
JIANGSU HANSOH PHARMA CO LTD
Filing Date
2026-01-15
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Existing liquid formulations of GLP-1/GIP dual receptor agonists face challenges in microbial growth and physicochemical stability in multi-dose packaging. The selection and dosage of antimicrobial agents are difficult to balance, affecting the efficacy and safety of the drugs.

Method used

A composition comprising a GIP/GLP-1 dual receptor agonist, an antibacterial agent, an osmotic pressure regulator, a buffer, and a pH regulator is provided, with the specific components and proportions optimized to ensure the antibacterial efficacy and stability of the drug, suitable for human injection administration.

Benefits of technology

This study achieved stability and safety in liquid formulations of GLP-1/GIP dual receptor agonists, reduced the risk of microbial contamination, and improved drug efficacy and safety.

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Abstract

The present invention relates to a pharmaceutical composition, a preparation method, and a pharmaceutical use of the pharmaceutical composition. Specifically, disclosed in the present invention is a pharmaceutical composition using a dual receptor agonist as an active ingredient. The pharmaceutical composition comprises a dual receptor agonist, a bacteriostatic agent, an osmotic pressure regulator, a buffering agent, and a pH regulator. In the present invention, the appropriate types and proportions of bacteriostatic agents are used, so that the bacteriostatic efficacy and stability of pharmaceutical formulations during transportation, storage, and use are ensured.
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