A method of selecting TCR for reducing off-target cross-reactivity and enhancing activation potency

By optimizing TCR-pMHC interactions through catch bond lifetimes and mechanical forces, the method addresses off-target cross-reactivity and enhances activation potency, improving the safety and efficacy of TCR therapies for diseases such as cancer and autoimmune disorders.

WO2026153432A1PCT designated stage Publication Date: 2026-07-23ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2026-01-15
Publication Date
2026-07-23

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  • Figure PCTCN2026072857-FTAPPB-I100001
    Figure PCTCN2026072857-FTAPPB-I100001
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    Figure PCTCN2026072857-FTAPPB-I100002
  • Figure PCTCN2026072857-FTAPPB-I100003
    Figure PCTCN2026072857-FTAPPB-I100003
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Abstract

Provided is a method of selecting variants of a T cell receptor (TCR) for reducing off-target cross-reactivity and / or enhancing activation potency, wherein said method comprising: screening a TCR of which a catch bond lifetime of said TCR to the non-self cognate peptide major histocompatibility (pMHC) thereof to within the range of about 0.1 second to about 5 seconds and / or screening a TCR of which an α angle between said TCR and the pMHC thereof to more than about 2 degrees.
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