Potentiation of the thrombolytic effect of soluble plasminogen activator by vesicles expressing urokinase receptors
The synergistic action of vesicles expressing urokinase receptors (uPAR) linked to urokinase-type plasminogen activator (uPA) and soluble urokinase enhances thrombolytic efficacy, addressing the limitations of current uPA therapies by accelerating clot lysis and improving therapeutic outcomes.
WO2026153933A1PCT designated stage Publication Date: 2026-07-23UNIV DAIX MARSEILLE +4
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- UNIV DAIX MARSEILLE
- Filing Date
- 2026-01-13
- Publication Date
- 2026-07-23
AI Technical Summary
Technical Problem
Current thrombolytic therapies using urokinase-type plasminogen activator (uPA) have a limited benefit/risk ratio due to a narrow therapeutic window and are ineffective against distal thrombi, particularly in conditions like sepsis, with a higher risk of hemorrhagic transformation.
Method used
A composition comprising vesicles expressing urokinase receptors (uPAR) linked to urokinase-type plasminogen activator (uPA) and soluble urokinase, enhancing thrombolytic effect through synergistic action.
Benefits of technology
The combination significantly accelerates clot lysis, demonstrating a synergistic effect that is uPAR-dependent and resistant to cleavage, improving therapeutic outcomes in thrombosis and catheter occlusions.
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Smart Images
Figure EP2026050691_23072026_PF_FP_ABST
Abstract
The present invention relates notably to a composition comprising: (i) at least a vesicle expressing urokinase receptors (uPAR) being linked to an urokinase-type plasminogen activator (uPA), and (ii) at least a soluble urokinase. It also relates to its use as a medicament in particular for the prevention and / or treatment of a thrombosis, of arterial and venous obstructions, of infectious coagulopathies, and in catheter deblocking or clearance and / or treatment of catheter occlusions.
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