Method for adapting hypoxia training to an altitude

Abstract

The invention relates to a method for performing hypoxia training with a hypoxicator (10) which has a pressure gauge (14) and a thermometer (12). The method comprises the following steps: Ambient air (20) of the hypoxicator (10), which surrounds the hypoxicator (10), is introduced into the hypoxicator (10), wherein non-optimized training air (24) in the hypoxicator (10) is composed of this introduced ambient air (20). A temperature of the ambient air (20) of the hypoxicator (10) is measured at a position of the thermometer (12). A pressure of the ambient air (20) is measured at a position of the pressure gauge (14). An initial amount of oxygen (26), which is the amount of oxygen (26) in the non-optimized training air (24), is determined from the measured pressure and the measured temperature. With the aid of the initial amount of oxygen (26), a differential amount (52) of oxygen (26) is calculated as the difference between a target amount of oxygen (26), in which optimized training air (40) has the same oxygen density as the oxygen density of air, in particular dry air, at sea level, and the initial amount of oxygen in the non-optimized training air (24). The differential amount of oxygen (26) is added to the non-optimized training air (24) in the hypoxicator (10), such that the non-optimized training air (24) is converted into the optimized training air (40), wherein the optimized training air (40) has the target amount of oxygen (26). A normoxic, hypoxic or hyperoxic training gas mixture (54) is generated from the optimized training air (40) and is used to perform hypoxia training on a patient.

Description

[0001] - 1 - 15.01.2026

[0002] SP13921PCT Applicant:

[0003] Rainer Goytia

[0004] Karlstrasse 40

[0005] 73663 Berglen

[0006] Germany

[0007] Representative:

[0008] Kohler Schmid Möbus

[0009] patent attorneys

[0010] limited liability partnership

[0011] Gropiusplatz 10

[0012] 70563 Stuttgart

[0013] Germany

[0014] Methods for adapting hypoxia training to altitude

[0015] Background of the invention

[0016] The invention relates to a method for conducting hypoxia training with a hypoxicator comprising a pressure gauge and a thermometer. The invention also relates to a hypoxicator for carrying out the method.

[0017] German patent DE 10 2012 010 806 A discloses a hypoxia therapy session in which the values ​​of a patient's peripheral oxygen saturation and pulse are transmitted to a monitoring device, while the patient is administered a hypoxic gas mixture alternately with a normoxic or hyperoxic gas mixture. The administration of the hypoxic gas mixture and the normoxic or hyperoxic gas mixture each takes place over a predetermined period.

[0018] If the known procedures for treating a patient through hypoxia training are carried out at a comparatively high altitude, there is a risk of complications.

[0019] Rainer Goytia SP13921PCT- 2 - 01 / 15 / 2026

[0020] The decrease in oxygen in the available air poses an increased health risk to the patient.

[0021] Object of the invention

[0022] It is therefore an object of the present invention to provide a method for conducting hypoxia training at high altitude, in which the health risk to the patient is significantly reduced. It is a further object of the invention to provide a hypoxicator for conducting the hypoxia training.

[0023] The problem is solved by a method with the features according to claim 1. A hypoxicator for carrying out hypoxia training has the features according to claim 5.

[0024] The procedure for conducting hypoxia training involves the following steps:

[0025] I. Introducing non-optimized training air from the environment of the hypoxicator into the hypoxicator;

[0026] II. Measuring a temperature T amb an ambient air of the hypoxicator at the location of the thermometer;

[0027] III. Measuring a pressure p ambthe ambient air of the hypoxicator at the location of the pressure gauge;

[0028] IV. Determining the oxygen density of the non-optimized training air using the measured temperature and pressure; V. Determining the difference in oxygen volume using the mass difference Am 02 , wherein the difference in the amount of non-optimized training air must be supplied to optimize the training air, where optimized training air has a target amount of oxygen with the target mass m O2soll exhibits, wherein the optimized training air at the target amount of oxygen has the same oxygen density as the oxygen density of, in particular, dry, air at sea level;

[0029] Rainer Goytia SP13921PCT- 3 - 01 / 15 / 2026

[0030] VI. Changing an existing initial amount of oxygen with initial mass m O2 ausin the non-optimized training air to convert the non-optimized training air into the optimized training air by the difference amount to the target amount of oxygen; VII. Performing hypoxia training by administering a training gas mixture, which is generated from the optimized training air, to a patient.

[0031] The process adjusts the oxygen content in the non-optimized training air to the target oxygen level, thereby creating optimized training air. As a result, the optimized training air, from which the training gas mixture is generated, has the same oxygen content as, in particular, dry, air at sea level. Therefore, hypoxic training can be safely and advantageously conducted regardless of the patient's altitude, using ambient air as the basis for the training. Altitude is measured relative to sea level.

[0032] The term "dry air" specifically refers to air that is free of water. The term "dry air" at sea level specifically refers to dry air that is subject to the conditions of the International Standard Atmosphere as defined by the ICAO (International Civil Aviation Organization). For example, the air pressure under the conditions of the International Standard Atmosphere is 1013.25 hPa.

[0033] A hypoxicator is understood to be a device by which a hypoxic gas mixture can be administered to a patient, wherein the hypoxic gas mixture is generated in particular from the ambient air surrounding the hypoxicator. The area surrounding the hypoxicator is understood to be, in particular, the space surrounding the hypoxicator at a distance of two meters, in particular one meter, preferably 50 cm, and most preferably 10 cm.

[0034] Rainer Goytia SP13921PCT- 4 - 01 / 15 / 2026

[0035] The non-optimized training air is, in particular, the air flowing into the hypoxicator from the surrounding environment. The mass difference of the difference in the amount of oxygen is, in particular, the difference between the mass of the target amount of oxygen and the initial amount of oxygen. The initial amount of oxygen is, in particular, the amount of oxygen that the non-optimized training air in the hypoxicator contains before the non-optimized training air is converted into optimized training air by changing its oxygen content. The initial amount of oxygen is, in particular, identical to the average of the density of oxygen of the ambient air in the hypoxicator or the density of oxygen of the non-optimized training air multiplied by the volume available to the non-optimized training air in the hypoxicator.The term oxygen density refers in particular to the mass of the amount of oxygen in a gas mixture, especially air, divided by the volume available to the gas mixture.

[0036] Non-optimized training air refers specifically to the air introduced into the hypoxicator from the surrounding environment to create a training gas mixture for hypoxic training. Optimized training air refers specifically to the air produced from the non-optimized training air by optimizing the oxygen content. A hypoxic training gas mixture refers specifically to a gas mixture produced from the optimized training air by removing oxygen. A hyperoxic training gas mixture refers specifically to a gas mixture produced from the optimized training air by adding oxygen. A normoxic training gas mixture refers specifically to a gas mixture containing the same proportion of oxygen as the optimized training air.

[0037] In a preferred embodiment of the method, the hypoxia training is performed while measuring a parameter that characterizes the oxygen saturation of the patient's blood. This advantageously improves the control of the hypoxia training.

[0038] Rainer Goytia SP13921PCT- 5 - 01 / 15 / 2026

[0039] In an advantageous embodiment of the process, the mass difference is Am 02 the difference in the amount of oxygen relative to the target amount of oxygen with the target mass m O2soll using the specific gas constant R SiLuft of, especially dry, air and the density p Luft:0 of, in particular dry, air at sea level according to the following formula:

[0040]

[0041] The target mass of oxygen is determined in particular by a volume V oT, which occupies the optimized training air in the hypoxicator during hypoxic training, preferably with a maximum such volume, according to the formula: m 02iS0 ii = p L uft,o x V OT ■ The density of, especially dry, air at sea level p Luft ,o and the volume V oT The volume of oxygen in the hypoxicator, which is filled by the optimized training air, is independent of the hypoxic training and / or can be determined before the training. Therefore, to determine the difference in volume according to the formula mentioned above, it is advantageous to measure the pressure and temperature of the ambient air. The difference in oxygen volume can thus be determined easily.

[0042] In a preferred embodiment of the method, the amount of oxygen and / or nitrogen in the non-optimized training air and / or the optimized training air is measured by the hypoxicator. Measuring the constituents of the non-optimized training air and / or the optimized training air allows for particularly safe and controlled hypoxic training. This applies especially to constituents that are present in high concentrations in the air, such as oxygen and nitrogen. The measurement is performed continuously.

[0043] According to an advantageous embodiment of the procedure, a hypoxic session index is used as a measure of the reaction during the hypoxia training according to step VII.

[0044] Rainer Goytia SP13921PCT- 6 - 01 / 15 / 2026

[0045] a patient's response to hypoxia training and a parameter characterizing the oxygen saturation of the patient's blood are measured, performing the following sub-steps i to vi of step VII:

[0046] i. Supplying the patient with a normoxic training gas mixture in an initial phase over a predetermined first period, wherein the normoxic training gas mixture is generated from the optimized training air;

[0047] ii. Determining the mean value of the parameter in the initial phase; iii. Supplying the patient with a hypoxic training gas mixture in a hypoxic phase over a predetermined hypoxic period, wherein the hypoxic training gas mixture is generated from the optimized training air;

[0048] iv. Supplying the patient with the normoxic or hyperoxic training gas mixture in a reoxygenation phase over a predetermined hyperoxia period and in a subsequent predetermined completion period, wherein the normoxic or hyperoxic training gas mixture is generated from the optimized training air;

[0049] v. Orders of the parameter over time in the initial phase, the hypoxia phase and the reoxygenation phase in the form of a data curve;

[0050] vi. Determining a hypoxic session index from a deviation of the data curve from a predetermined reference curve.

[0051] The deviation between the data curve and the reference curve allows for a quantitative evaluation of oxygen saturation measurements. The key parameter is, in particular, the oxygen saturation or partial pressure of oxygen dissolved in the patient's blood, the relationship between which is represented by the oxygen dissociation curve with a sigmoidal shape. The deviation is determined, in particular, by the distance between the data curve and the reference curve or by comparing the areas bounded by the data curve or the reference curve.

[0052] Rainer Goytia SP13921PCT- 7 - 01 / 15 / 2026

[0053] A hypoxia safety value, which in particular indicates the smallest value to which the parameter may fall during the hypoxia phase, is in particular between 70% and 88% of the mean value of the parameter in the initial phase, and in particular at 80% of the mean value of the parameter in the initial phase.

[0054] In the initial phase, the patient is not physically stressed and breathes ambient air and / or a normoxic gas mixture. The patient is in a resting position, specifically lying on a couch. During this initial phase, the device for measuring the Hypoxic Session Index is calibrated. This initial phase lasts between 1 and 5 minutes. During this initial phase, a key parameter, such as the partial pressure of oxygen, is measured and recorded, preferably every second, for a period between 20 and 120 seconds, particularly 30 seconds, before the start of the first hypoxic phase. After the initial phase, the mean value of the key parameter is calculated to establish a baseline for the parameter during the hypoxic training. The predetermined hypoxic and / or hyperoxic period lasts between 1 and 15 minutes.The determination of the mean value of the parameter in the initial phase according to step ii is carried out, in particular, before the hypoxic phase according to step iii, preferably during the initial phase or at the end of the initial phase. In an alternative embodiment of the method, the hypoxic phase according to step iii and the hyperoxic phase according to step iv are interchanged.

[0055] A hypoxicator for carrying out the aforementioned procedure has the following characteristics:

[0056] a) An inlet for introducing non-optimized training air into the hypoxicator;

[0057] b) A mask for delivering a hypoxic, normoxic and / or hyperoxic training gas mixture, generated from optimized training air, to a patient;

[0058] c) a control system for controlling the hypoxicator;

[0059] Rainer Goytia SP13921PCT- 8 - 01 / 15 / 2026

[0060] d) a gas mixer for producing optimized training air from non-optimized training air and / or a training gas mixture from optimized training air;

[0061] e) a thermometer for measuring the temperature of the ambient air of the hypoxicator at the location of the thermometer;

[0062] f) a pressure gauge for measuring the pressure of the ambient air of the hypoxicator at the location of the pressure gauge.

[0063] Such a device allows the amount of oxygen in optimized training air, which is provided for hypoxic training, to be adjusted independently of the altitude, in order to make the hypoxic training particularly safe.

[0064] In an advantageous embodiment, the hypoxicator includes a sensor, in particular a finger clip, wherein the sensor serves to measure a pulse and / or a parameter that characterizes the oxygen saturation of the patient's blood. Such a sensor can advantageously improve the control of hypoxia training.

[0065] Further advantages of the invention will become apparent from the description and the drawing. Likewise, the features mentioned above and those described in more detail below can each be used individually or in any combination. The embodiments shown and described are not to be understood as an exhaustive list, but rather serve as examples illustrating the invention.

[0066] Detailed description of the invention and drawing

[0067] Fig. 1 schematically shows a hypoxicator for adjusting the oxygen content of non-optimized training air in the hypoxicator; Fig. 2 schematically shows the hypoxicator with an oxygen chamber of a gas mixer open to adjust the oxygen content of the non-optimized training air;

[0068] Rainer Goytia SP13921PCT- 9 - 01 / 15 / 2026

[0069] Fig. 3 schematically shows the hypoxicator, in which the training air is optimized by adjusting the oxygen content;

[0070] Fig. 4 schematically shows the hypoxicator, in which a gas mixture generated from the optimized training air is directed to a mask of the hypoxicator;

[0071] Fig. 5 schematically shows the course of hypoxia training with the hypoxicator.

[0072] Fig. 1 schematically shows a hypoxicator 10 with a thermometer 12, a pressure gauge 14, and a control unit 16 for controlling the hypoxicator 10. The hypoxicator 10 is designed with an inlet 18 through which non-optimized training air 24 from the environment of the hypoxicator 10 flows into an air chamber 22 of the hypoxicator 10. The non-optimized training air 24 fills a training volume in the hypoxicator 10, in particular the volume of the air chamber 22.

[0073] The ambient air 20 surrounding the hypoxicator 10 and the non-optimized training air 24 within the hypoxicator 10 contain oxygen molecules 26 and other typical components 28 of air (e.g., nitrogen or argon). The oxygen molecules 26 are symbolized in the figures by empty circles, and the other typical components 28 of air by filled circles. A gas mixer 30 of the hypoxicator 10 is configured with chambers 32 and 34, wherein one chamber 32 contains predominantly, in particular more than 90%, oxygen 26, and another chamber 34 contains predominantly, in particular more than 90%, other typical components 28 of air.

[0074] The fluidic ports 36, 38 of the chambers 32, 34 can be switched to an active, in particular open, and an inactive, in particular closed, state. In the active state (see Fig. 2), the fluidic ports 36, 38 serve for the fluidic exchange of the non-optimized training air 24 and / or optimized training air 40 (see Fig. 3) in the air chamber 22 with the oxygen 26 and the other typical components 28 of air in the chambers 32, 34 of the gas mixer 30. By activating a fluidic

[0075] Rainer Goytia SP13921PCT- 10 - 01 / 15 / 2026

[0076] At connection 36, 38, the amount of the respective typical component 26, 28 of air from the associated chamber 32, 34 can be increased or decreased in the non-optimized training air 24. In particular, oxygen 26 can be added to or removed from the training air.

[0077] An outlet 42 of the hypoxicator 10 serves as the fluidic connection between the air chamber 22 of the hypoxicator 10 and a mask 44 of the hypoxicator 10 (see Fig. 4). The mask 44 is placed on a patient during hypoxia training. In Fig. 1, the outlet 42 is closed with an outlet closure 46, thus interrupting the fluidic connection to the mask 44. The hypoxicator 10 also has a sensor 48 with which a parameter, KG, can be measured to control the hypoxia training (see Fig. 5). The sensor 48 is designed, in particular, as a finger clip.

[0078] Fig. 2 schematically shows the hypoxicator 10, wherein the inlet 18 of the hypoxicator 10 is closed by an inlet closure 50, so that no ambient air 20 flows into the hypoxicator 10. The thermometer 12 determines the temperature of the ambient air 20 at the location of the thermometer 12. The pressure gauge 14 determines the pressure of the ambient air 20 at the location of the pressure gauge 14. From the measured temperature and the measured pressure, the control unit 16 of the hypoxicator 10 calculates the proportion of oxygen 26 in the ambient air 20 and thus in the non-optimized training air 24 in the air chamber 22.

[0079] The control unit 16 then determines a difference 52 between the initial amount of oxygen 26 in the non-optimized training air 24 and a target amount of oxygen 26 that the optimized training air 40 (see Fig. 3) generated from the non-optimized training air 24 should have. The target amount is the quantity of oxygen 26 at which the optimized training air 40 has the same oxygen density as the oxygen density of, in particular, dry air at sea level. The non-optimized training air 24 and / or the optimized training air 40 is, in particular, dry air or has a water content of no more than 1%.

[0080] Rainer Goytia SP13921PCT- 11 - 01 / 15 / 2026

[0081] related to the mass of the respective training air. The term oxygen density refers in particular to the mass of the amount of oxygen 26 in a gas mixture divided by the volume available to the gas mixture. In the embodiment shown, the non-optimized training air 24 and / or the optimized training air 40 have, in particular, the volume of the air chamber 22 available.

[0082] Fig. 3 schematically shows the hypoxicator 10, with the fluidic connection 36 of the oxygen 26-filled chamber 32 of the gas mixer 30 open, allowing oxygen 26 to flow from this chamber 32 into the air chamber 22 of the hypoxicator 10. In the optimized training air 40 shown in Fig. 3, the amount of oxygen 26 is increased by the previously determined difference 52 compared to the non-optimized training air 24 (see Fig. 1). The optimized training air 40 contains the target amount of oxygen 26. This reduces the health risks to a patient connected to the mask 44 during hypoxia training.

[0083] Fig. 4 schematically shows the hypoxicator 10, wherein the outlet closure 46 of the outlet 42 of the hypoxicator 10 is open during hypoxia training, so that a training gas mixture 54 generated from the optimized training air 40 flows through the outlet 42 to the mask 44. This can be a normoxic training gas mixture 54 in which the amount of oxygen 26 is identical to the target amount of oxygen 26. During hypoxia training, a hypoxic training gas mixture 54 can also be directed through the outlet 42 to the mask 44, wherein the hypoxic training gas mixture 54 is generated, in particular, by removing oxygen 26 from the optimized training air 40, preferably by a fluidic exchange with the corresponding chamber 32 of the gas mixer 30.Furthermore, a hyperoxic training gas mixture 54 can be generated, wherein the hyperoxic training gas mixture 54 is generated in particular by adding oxygen 26 to the optimized training air 40, preferably by a fluidic exchange with the corresponding chamber 32 of the gas mixer 30.

[0084] Rainer Goytia SP13921PCT- 12 - 01 / 15 / 2026

[0085] Fig. 5 schematically shows a data curve 56 of the parameter KG, which is recorded in a procedure for conducting hypoxia training over a measurement period MT in an initial phase AP, a hypoxia phase HP, and a reoxygenation phase RP. The parameter KG is, in particular, the oxygen saturation and / or the partial pressure of oxygen dissolved in the patient's blood. A predetermined reference curve 58, with which the data curve 56 is compared, is also shown.

[0086] A hypoxia baseline 60a of the reference curve 58 and a hypoxia baseline 60b of the data curve 56 are obtained by plotting the mean of measured values ​​of the parameter KG over the measurement time MT in the initial phase AP of the hypoxia training. During the initial phase AP, the patient is supplied with a normoxic training gas mixture 54 (see Fig. 4).

[0087] The hypoxia phase HP begins at an initial time point AZP. During the hypoxia phase HP, the patient is supplied with a hypoxic training gas mixture 54 (see Fig. 4) for a predetermined hypoxia period until the parameter KG falls to a hypoxia value 62 that is greater than a predetermined hypoxia safety value 64, which is plotted as a hypoxia safety value line over the measurement time MT.

[0088] In the subsequent reoxygenation phase (RP), the patient is administered a hyperoxic training gas mixture 54. During the reoxygenation phase (RP), the reference curve 58 and the data curve 56 rise to a hyperoxia reference value (HRW), which is schematically represented here as the same value for both the reference curve 58 and the data curve 56.

[0089] A predetermined HCS reference value 66 of the parameter KG is smaller than the mean value of the parameter in the initial phase and larger than the hypoxia safety value 64. The HCS reference value 66 is represented as the HCS reference line of the hypoxia phase over the measurement time MT, the end of which is represented by a vertical line. An HCS determination surface 68 is defined as the area between the data curve 56 and the HCS reference line 66 in the hypoxia phase HP.

[0090] Rainer Goytia SP13921PCT- 13 - 01 / 15 / 2026

[0091] An HCS reference area 70 is defined as the area between reference curve 58 and HCS reference line 66 during the hypoxic phase (HP). The Hypoxic Cycle Score, used to assess the patient's response to hypoxic training, is defined as the ratio and / or difference between the HCS determination area 68 and the HCS reference area 70. The Hypoxic Cycle Score is specifically incorporated into the determination of a Hypoxic Session Index, which preferably represents, by means of one or more indices, a deviation of the data curve 56 from the reference curve 58. In particular, the Hypoxic Cycle Score is identical to the Hypoxic Session Index.

[0092] Considering all the figures in the drawing together, the invention relates to a method for conducting hypoxia training with a hypoxicator 10, which includes a pressure gauge 14 and a thermometer 12. The method comprises the following steps: Ambient air 20 surrounding the hypoxicator 10 is introduced into the hypoxicator 10, the non-optimized training air 24 in the hypoxicator 10 being composed of this introduced ambient air 20. The temperature of the ambient air 20 of the hypoxicator 10 is measured at a position of the thermometer 12. The pressure of the ambient air 20 is measured at a position of the pressure gauge 14. From the measured pressure and temperature, an initial quantity of oxygen 26 is determined, which is the quantity of oxygen 26 in the non-optimized training air 24.Using the initial amount of oxygen 26, a difference amount 52 of oxygen 26 is calculated as the difference between a target amount of oxygen 26, at which optimized training air 40 has the same oxygen density as the oxygen density of, in particular, dry, air at sea level, and the initial amount of oxygen in the non-optimized training air 24. The difference amount of oxygen 26 is added to the non-optimized training air 24 in the hypoxicator 10, so that the non-optimized training air 24 is converted into the optimized training air 40, where the optimized training air 40 has the target amount of oxygen 26. From the optimized training air 40, a normoxic, hypoxic, or hyperoxic training air is produced.

[0093] Rainer Goytia SP13921PCT- 14 - 01 / 15 / 2026

[0094] Gas mixture 54 is produced, with which hypoxia training is performed on a patient.

[0095] Rainer Goytia SP13921PCT

Claims

- 15 - 15.01.2026 Patent claims 1. Method for performing hypoxia training with a hypoxicator (10) comprising a pressure gauge (14) and a thermometer (12), the method comprising the following steps: I. Introducing non-optimized training air (24) from the environment of the hypoxicator (10) into the hypoxicator (10); II. Measuring a temperature T amb the ambient air (20) of the hypoxicator (10) at the location of the thermometer (12); III. Measuring a pressure p amb the ambient air (20) of the hypoxicator (10) at the location of the pressure gauge (14); IV. Determining the oxygen density of the non-optimized training air (24) using the measured temperature T amb and the measured pressure p amb ; V. Determining a difference quantity (52) of oxygen (26) with the mass difference Am O2, wherein the difference quantity (52) of the non-optimized training air (24) must be supplied for optimization, wherein an optimized training air (40) has a target quantity of oxygen (26) with the target mass m O2 , soii exhibits, wherein the optimized training air (40) at the target amount of oxygen (26) has the same oxygen density as the oxygen density of, in particular, dry, air at sea level; VI. Changing an existing initial amount of oxygen (26) with initial mass m O2 , aus in the non-optimized training air (24) to convert the non-optimized training air (24) into the optimized training air (40) to the target amount of oxygen (26); VII. Performing hypoxia training by administering a training gas mixture (54) generated from the optimized training air (40) to a patient. Rainer Goytia SP13921PCT- 16 - 01 / 15 / 2026 2. The method according to claim 1, wherein the hypoxia training is performed while measuring a parameter that characterizes the oxygen saturation of the patient's blood.

3. Method according to one of the preceding claims, wherein the mass difference Am 02 the difference in the amount (52) of oxygen (26) relative to the target amount of oxygen (26) with the target mass m 02iS0 ii using the specific gas constant R S:Luft of, especially dry, air and the density p Luft ,o of, in particular dry, air at sea level is determined according to the following formula: > 4. Method according to one of the preceding claims, wherein the amount of oxygen (26) and / or the amount of nitrogen in the non-optimized training air (24) and / or the optimized training air (40) is measured by the hypoxicator (10).

5. A method according to any of the preceding claims, wherein, within the framework of the hypoxia training according to step VII, a hypoxic session index is measured as a measure of the patient's response to the hypoxia training and a parameter KG, which characterizes the oxygen saturation of the patient's blood, is measured, comprising the following sub-steps i to vi of step VII: i. Supplying the patient with a normoxic training gas mixture (54) in an initial phase (AP) over a predetermined first period, wherein the normoxic training gas mixture (54) is generated from the optimized training air (40); ii. Determining the mean value of the parameter (KG) in the initial phase; iii. Supplying the patient with a hypoxic training gas mixture (54) in a hypoxic phase (HP) over a predetermined hypoxic period, wherein the hypoxic training gas mixture (54) is generated from the optimized training air (40); Rainer Goytia SP13921PCT- 17 - 01 / 15 / 2026 iv. Supplying the patient with the normoxic or hyperoxic training gas mixture (54) in a reoxygenation phase (RP) over a predetermined hyperoxia period and in a subsequent predetermined completion period, wherein the normoxic or hyperoxic training gas mixture (54) is generated from the optimized training air; v. Orders of the parameter (KG) over time in the initial phase (AP), the hypoxic phase (HP) and the reoxygenation phase (RP) in the form of a data curve (56); vi. Determining a hypoxic session index from a deviation of the data curve (56) from a predetermined reference curve (58).

6. Hypoxicator (10) for carrying out a method according to one of the preceding claims, comprising: a) an inlet (18) for introducing non-optimized training air (24) into the hypoxicator (10); b) A mask (44) for delivering a hypoxic, normoxic and / or hyperoxic training gas mixture (54) generated from optimized training air (40) to a patient; c) a control unit (16) for controlling the hypoxicator (10); d) a gas mixer (30) for generating the optimized training air (40) from the non-optimized training air (24) and / or a training gas mixture (54) from the optimized training air (40); e) a thermometer (12) for measuring the temperature of an ambient air (20) of the hypoxicator (10) at the location of the thermometer (12); f) a pressure gauge (14) for measuring the pressure of the ambient air (20) of the hypoxicator (10) at the location of the pressure gauge (14).

7. Hypoxicator (10) according to claim 6, wherein the hypoxicator comprises a sensor (48), in particular a finger clip, for measuring a pulse and / or a parameter that characterizes the oxygen saturation of the patient's blood. Rainer Goytia SP13921PCT

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