A tumor-specific HLA-bound neoantigenic peptide encoded by EWSR1::FLI1-induced neogenes

Tumor-specific neoantigenic peptides encoded by EWSR1::FLI1-induced neogenes provide a targeted immune response for Ewing sarcoma treatment, enhancing treatment efficacy while minimizing autoimmune risks.

WO2026154125A2PCT designated stage Publication Date: 2026-07-23INSTITUT CURIE +1
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
INSTITUT CURIE
Filing Date
2026-01-16
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Current treatments for Ewing sarcoma are ineffective due to low immunogenicity and immune tolerance, with a 5-year survival rate of only 30% for metastatic cases, and there is a lack of identified tumor-specific HLA-bound neoantigenic peptides encoded by EWSR1::FLI1-induced neogenes for targeted immune response.

Method used

Identification and utilization of tumor-specific neoantigenic peptides encoded by EWSR1::FLI1-induced neogenes, which are expressed in Ewing sarcoma cells but not healthy cells, to develop vaccines and immunotherapies that activate CD8 T cells to specifically target and kill tumor cells.

Benefits of technology

The peptides enable targeted immune responses against Ewing sarcoma, potentially increasing treatment efficacy and reducing autoimmune risks, as demonstrated by CD8 T cells' ability to recognize and kill Ewing sarcoma cells in an HLA-restricted manner.

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Abstract

The present invention provides tumor-specific HLA-bound neoantigenic peptides encoded by EWSR1::FLI1-Induced neogenes, vaccinal compositions comprising such tumor-specific neoantigenic peptides, nucleic acids, antibodies or fragments thereof and immune cells that can be used in cancer therapy, particularly in Ewing sarcoma.
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