Multifunctional electronic wound dressing medical device for wound treatment and manufacturing method therefor

Abstract

The present invention relates to an electronic wound dressing for wound healing and a manufacturing method therefor. The electronic wound dressing according to the present invention comprises anode and cathode microelectrode arrays that generate oxygen or hydrogen by the application of external power to the wound dressing, and thus is highly effective in supplying oxygen to the wound site and decomposing exudate generated from the wound, and providing anti-inflammatory relief through hydrogen generation. Furthermore, the electronic wound dressing according to the present invention is highly effective in promoting cell regeneration and angiogenesis, as two electrodes functioning as the anode and cathode microelectrode arrays generate an electric field upon application of external power through control and the like of the spacing between the electrodes, and the generated electric field causes cells to migrate toward the cathode.

Description

Multifunctional electronic wound dressing medical device for wound treatment and method of manufacturing the same

[0001] The present invention relates to a multifunctional electronic wound dressing medical device for wound treatment and a method for manufacturing the same.

[0002] The skin is the body's first line of defense and plays a vital role in protecting the body from external stimuli and pathogens. When the skin is wounded, immediate repair is required, and the injury can affect not only the epithelial layer but also the underlying subcutaneous tissue.

[0003] Meanwhile, as industrial society develops, the likelihood of skin damage caused by various factors such as wounds, pressure ulcers, deep burns, trauma, and skin diseases is increasing; in such cases, wounds that cannot heal can leave severe defects that necessitate skin grafting. Among these, a wound refers to a state in which tissue continuity is destroyed by external pressure. Skin wounds occur frequently due to various causes, and their healing requires a complex process involving the interaction of various molecules, such as cytokines and growth factors, that induce the growth and regeneration of the injured tissue.

[0004] Wound healing, as currently understood, is a complex physiological process involving various cells and chemical mediators, broadly divided into three stages: the inflammatory stage, the proliferative stage, and the remodeling stage. During the inflammatory stage, blood vessels constrict, platelets aggregate to stop bleeding, and inflammatory cells migrate to the wound site to defend against infection and remove damaged tissue. Subsequently, in the proliferative stage, new blood vessels and granulation tissue are formed, and fibroblasts synthesize collagen to repair the wound site. Finally, in the remodeling stage, the wound tissue matures and epithelialization is completed, restoring it to normal skin tissue. This process is regulated by various growth factors that play a crucial role in promoting cell migration and tissue regeneration.

[0005] However, patients with chronic diseases such as diabetes are highly likely to develop chronic wounds because the wound healing process does not proceed normally. Diabetic wounds tend to stop at the inflammatory stage primarily due to vascular damage, microcirculatory disorders, reduced cell migration, and a lack of growth factors. This prevents inflammation from progressing to the proliferative phase, thereby delaying or worsening wound healing; in particular, hypoxia is one of the major factors that makes the healing of chronic wounds even more difficult. In the site of a chronic wound, insufficient blood flow leads to inadequate oxygen supply, which inhibits angiogenesis and cell proliferation and hinders tissue regeneration.

[0006] To address these issues, recently utilized local oxygenation systems are attracting attention as an effective method that promotes tissue regeneration and angiogenesis by directly delivering oxygen to the wound site. While Hyperbaric Oxygen Therapy (HBOT) is already used for the treatment of chronic wounds, there are limitations to its systemic oxygen delivery method. Accordingly, local oxygenation systems developed to address this issue can accelerate tissue recovery by delivering oxygen directly to the wound site. These systems generate oxygen using compounds such as hydrogen peroxide or calcium oxide, enabling more effective oxygen delivery than conventional systemic oxygen therapy. In particular, technologies capable of providing continuous oxygen over the long term demonstrate the potential to accelerate healing in chronic wounds, especially diabetic wounds.

[0007] Furthermore, electrical stimulation therapy is being studied as another important method for promoting wound healing. Healthy skin possesses a natural potential difference of approximately 10 to 60 mV; when a wound occurs, this potential is lost, and an electric current flows to the wound site. This current plays a crucial role in the wound healing process, contributing to the promotion of cell migration and tissue regeneration. By mimicking this natural current using external electrical stimulation and artificially supplying current to the wound site, the healing process can be accelerated. In particular, appropriate electrical stimulation has been proven effective in alleviating inflammation, promoting angiogenesis, and stimulating cell migration and proliferation. International wound care guidelines also recommend electrical stimulation therapy for chronic wounds, and it has the advantage of being painless, allowing for treatment using various frequencies and waveforms.

[0008] Meanwhile, the pH of a wound plays a crucial role in the wound healing process. Generally, healthy skin maintains a slightly acidic pH (4–6.5), which protects the skin barrier and inhibits the proliferation of pathogenic microorganisms. However, when a wound occurs, the pH of the wound site becomes alkaline; this alkaline environment promotes bacterial growth and hinders wound healing. Conversely, maintaining a slightly acidic environment at the wound site can inhibit bacterial growth and promote cell migration, thereby accelerating wound healing. Recent studies suggest that maintaining a slightly acidic environment is an important treatment strategy for chronic wounds, particularly those at high risk of infection, and that pH regulation can play a vital role in wound recovery.

[0009] Accordingly, there is a growing need to manufacture wound dressings that can enhance the efficiency of a combined treatment involving the promotion of cell migration via an electric field resulting from electrical stimulation and the alleviation of inflammation, by utilizing exudate generated at a local wound site as a hydrogen or oxygen-generating fuel and configuring materials that selectively generate hydrogen or oxygen as positive and negative electrodes.

[0010] The present invention was devised to solve the aforementioned problems. The inventors have made diligent research efforts to manufacture a wound dressing capable of enhancing the efficiency of a combined treatment that promotes cell migration via an electric field resulting from electrical stimulation and alleviates inflammation. As a result, the present invention was completed by manufacturing a wound dressing that utilizes exudate generated from a local wound site as a fuel for hydrogen or oxygen generation, and configures materials that selectively generate hydrogen or oxygen as positive and negative electrodes.

[0011] Accordingly, the object of the present invention is to provide an electronic wound dressing for wound healing comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0012] Another objective of the present invention is to provide an electronic wound dressing kit for wound healing comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0013] Another objective of the present invention is to provide a method for manufacturing an electronic wound dressing for wound healing, comprising the step of placing a microelectrode that generates oxygen or hydrogen in a microelectrode array.

[0014] Another objective of the present invention is to provide a method for treating a wound using an electronic wound dressing for wound healing comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0015] To achieve the above objectives, the inventors applied an external power source to a wound dressing through the following embodiment and transferred it to an anode and a cathode to form oxygen or hydrogen.

[0016] According to one embodiment of the present invention, two electrodes acting as positive and negative electrodes formed in an electronic wound dressing can generate electric fields of various magnitudes by controlling the spacing between the electrodes when an external power source is applied. Wound healing can be accelerated by using the generated electric field to promote cell migration. In addition, the electric field causes cells to move toward the negative electrode, thereby promoting cell regeneration and angiogenesis, which can improve the regenerative capacity of the wound site. In particular, through electrical stimulation, cells important for wound healing, such as fibroblasts and keratinocytes, can migrate rapidly to assist in the re-epithelialization process.

[0017] According to another embodiment of the present invention, hydrogen generated at the cathode has an anti-inflammatory effect and can aid in wound healing by alleviating inflammation at the wound site. Hydrogen can promote the recovery of the wound site by reducing inflammatory responses and preventing tissue damage through the action of inhibiting reactive oxygen species (ROS).

[0018] According to another embodiment of the present invention, the electrical stimulation of the present invention can accelerate tissue regeneration at the wound site by not only migrating cells but also promoting angiogenesis and collagen synthesis.

[0019] According to another embodiment of the present invention, the wound dressing of the present invention may generate oxygen at the positive electrode by applying an external power source formed in the wound dressing, and the oxygen may resolve the problem of oxygen deficiency at the wound site and decompose exudate generated at the wound. In addition, the oxygen may help to heal the wound more quickly by preventing infection through antibacterial action and inhibiting the proliferation of bacteria at the wound site.

[0020] According to another embodiment of the present invention, the wound dressing of the present invention has a complex therapeutic effect in the wound healing process through the combined effect of oxygen and hydrogen generated at the positive and negative electrodes, the promotion of cell migration using an electric field, and the effect of alleviating inflammation. As a result, wounds that are difficult to heal with conventional treatments, such as chronic wounds or diabetic ulcers, can be effectively treated in a very short period of time.

[0021] The configuration of the present invention will be described in detail below.

[0022] One aspect of the present invention is an electronic wound dressing for wound healing comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0023] In the present invention, the microelectrode wire comprises one or more micro positive electrodes and one or more micro negative electrodes, and

[0024] The above one or more micro-positive electrodes and the above one or more micro-negative electrodes may generate one or more selected from the group consisting of coral and hydrogen in response to applied electricity from an environment where exudate is present.

[0025] In this specification, the term “wound” refers to a condition in which the continuity of tissue is destroyed by external pressure. Wounds may include abrasions, contusions, lacerations, and cuts caused by blades. They may also include chronic wounds that may occur due to a failure of the wound healing process caused by chronic diseases such as diabetes.

[0026] As used in this specification, the term “wound dressing” refers to a material used to prevent primary infection by covering the surface of a wound with a wound dressing or similar material when a wound occurs in skin tissue, thereby preventing the wound from being exposed to various external infectious agents such as bacteria, germs, and viruses, and protecting the wound from the outside. In addition, it maintains the moisture level of the wound area to prevent fluid loss in the wound area and surrounding tissues, and prevents tissue contraction that may occur during the healing process, thereby preventing secondary skin tissue damage.

[0027] The wound dressing provided in the present invention may be provided in the form of a sheet, a gel, etc., and may additionally include various conventional additives. The types of these additives are not particularly limited, but may include, for example, dyes, coloring pigments, vegetable oils, thickeners, pH adjusters, osmotic pressure regulators, vitamins, antioxidants, inorganic salts, preservatives, solvents, isotonic agents, suspending agents, emulsifiers, stabilizers, anesthetics, disinfectants, wound healing agents, etc.

[0028] In the present invention, the microelectrode wire array may be formed with a structure of an interdigitated electrode (IDE), a side-by-side electrode (SDE), a concentric ring electrode, a spiral, or a fractal electrode pattern, but is not limited thereto.

[0029] In the present invention, the microelectrode that generates oxygen is

[0030] A micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides.

[0031] The microcathode may comprise one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene, activated carbon / carbon black, carbon derived from a metal-organic framework (MOF), nitrogen-doped carbon, molybdenum disulfide (MoS2), and nickel-molybdenum alloy (NiMo alloy), but is not limited thereto.

[0032] The above perovskite-type oxides are LaNiO3, LaCoO3, and Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3- It may be one or more selected from the group consisting of δ, but is not limited thereto.

[0033] In the present invention, the microelectrode that generates hydrogen is

[0034] A micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides.

[0035] The microcathode may comprise one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene and activated carbon / carbon black, metal-organic framework (MOF) derived carbon, nitrogen-doped carbon, molybdenum disulfide (MoS2) and nickel-molybdenum alloy (NiMo alloy), but is not limited thereto.

[0036] The above perovskite-type oxides are LaNiO3, LaCoO3, and Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3- It may be one or more selected from the group consisting of δ, but is not limited thereto.

[0037] In the present invention, the microelectrode that generates oxygen and hydrogen is

[0038] The micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides.

[0039] The microcathode may comprise one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene and activated carbon / carbon black, metal-organic framework (MOF) derived carbon, nitrogen-doped carbon, molybdenum disulfide (MoS2) and nickel-molybdenum alloy (NiMo alloy), but is not limited thereto.

[0040] The above perovskite-type oxides are LaNiO3, LaCoO3, and Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3- It may be one or more selected from the group consisting of δ, but is not limited thereto.

[0041] In the present invention, the microelectrode wire array may form an electric field between a micro positive electrode and a micro negative electrode, but is not limited thereto.

[0042] In the present invention, the electric field formed between the micro anode and the micro cathode may be formed without oxygen or hydrogen generation when a DC electric bias of 0.025 to 1 V and 0.01 to 1 mA is applied, but is not limited thereto.

[0043] The magnetic field formed when a direct current electric bias of 0.025 to 1 V and 0.01 to 1 mA is applied can promote cell migration at the wound site.

[0044] In the present invention, the micro cathode may be one in which hydrogen is generated at the cathode electrode portion when a DC electric bias of 1.5 to 2.99 V and 2 mA or less is applied, but is not limited thereto.

[0045]

[0046] In the present invention, the micro anode and micro cathode may be such that oxygen or hydrogen is generated at the anode electrode and cathode electrode portions when a DC electric bias of 3 to 5 V and 2 mA or less is applied, but is not limited thereto.

[0047] Oxygen or hydrogen generated at the positive and negative electrode sites when a DC electric bias of 3 to 5 V and 2 mA or less is applied can promote an anti-inflammatory effect on the wound site.

[0048]

[0049] In the present invention, the sheet may be a sheet capable of decomposing exudate generated in a wound, and may be formed of one or more selected from the group consisting of hydrogel, polyurethane foam, alginate, chitosan, silicone-based wound dressing, cellulose series, and polyvinyl alcohol (PVA) hydrogel, but is not limited thereto.

[0050] In the present invention, the sheet may comprise a release layer laminated on the upper surface of an attachment layer, an absorption layer laminated on the other upper surface of the attachment layer, and a release layer laminated on the other upper surface of the absorption layer, but is not limited thereto.

[0051] In the present invention, a microelectrode wire array is disposed between the attachment layer and the absorption layer, and the absorption layer may absorb one or more selected from the group consisting of oxygen and hydrogen generated from the microelectrode.

[0052] In the present invention, the electronic wound dressing comprises a sheet, and the microelectrode wire array included in the electronic wound dressing described above may preferably be disposed inside the hydrogel sheet.

[0053] In the present invention, the absorbent layer may comprise a hydrogel, and the hydrogel included in the absorbent layer is a three-dimensional structure composed of a network of hydrophilic molecules, with most of its components consisting of water. The hydrogel possesses high water content, a porous structure, and biocompatible properties. The hydrogel can exhibit various properties depending on which polymer is designated as the main chain or the method of crosslinking. The hydrogel can primarily be used as an auxiliary material for the treatment of burns or trauma, and is used to prevent water leakage from the body, absorb exudate, and prevent bacterial invasion and infection from the outside. Due to the properties of the hydrogel, it can protect the wound from additional bacterial infection and provide a moisturizing effect, and by enabling the absorption of exudate, it also plays a role in preventing inflammatory reactions occurring at the wound site.

[0054] In the present invention, the hydrogel may be one or more selected from the group consisting of alginate, chitosan, gelatin, hyaluronic acid, polyacrylamide, polyvinyl alcohol (PVA), polyethylene glycol (PEG), and chitosan-PEG composite hydrogel, but is not limited thereto.

[0055] Another aspect of the present invention is an electronic wound dressing kit for wound healing comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0056] In the present invention, the microelectrode wire array comprises one or more micro positive electrodes and one or more micro negative electrodes, and

[0057] The above one or more micro-anode electrodes and the above one or more micro-cathode electrodes may react with applied electricity to generate one or more selected from the group consisting of oxygen and hydrogen from an environment where exudate is present.

[0058] In the present invention, the electric wound dressing kit may additionally include a power supply unit, a sensor unit, and a control unit, but is not limited thereto.

[0059] In the present invention, the power supply unit may use a lithium-ion battery (NiMH, lithium polymer battery), an alkaline battery, a rechargeable battery, a hydrogen fuel cell, a methanol fuel cell, a solar cell, a supercapacitor (capacitive power supply), a DC power supply, or USB-PD (USB-power Delivery), etc.

[0060] In the present invention, the sensor unit may sense the pH concentration or temperature on the hydrogel sheet and provide information to the MCU.

[0061] Sensors capable of measuring the pH concentration on the hydrogel sheet may include ion-sensitive field-effect transistors, electrolyte-insulator-semiconductor (EIS) sensors, electrode-based semiconductor sensors, or NEMS (Nanoelectromechanical Systems)-based pH sensors.

[0062] Sensors capable of measuring the temperature on the hydrogel sheet may include PN junction diode sensors, resistance temperature detectors (RTDs), thermistors, integrated circuit temperature sensors (IC Temperature Sensors), thermocouples, or MOSFET-based temperature sensors.

[0063] In the present invention, the control unit may include an MCU (Micro Controller Unit) and a direct current bias.

[0064] As used herein, the term MCU refers to a small computer that plays a crucial role in electrical and electronic systems. An MCU integrates a CPU, memory, and I / O devices onto a single chip to perform various control tasks. Due to their small size and low power consumption, MCUs are used in battery-powered devices or embedded systems. They are suitable for real-time tasks that require immediate response to sensor signals and are used to control sensors and process data.

[0065] In this specification, Direct Current Bias refers to the application of a constant direct current (DC) voltage or current to maintain specific operating conditions in an electronic circuit. Direct Current Bias is primarily used to stabilize the operation of non-linear devices such as amplifiers, transistors, and diodes. Examples of DC bias include transistor circuits and Operational Amplifiers (OPs).

[0066] In the present invention, a DC bias of 0.025 to 1 V and 0.01 to 1 mA may be applied. When the DC bias of 0.025 to 1 V and 0.01 to 1 mA is applied, oxygen or hydrogen may not be generated in the micro anode and micro cathode.

[0067] In one embodiment of the present invention, when a DC electric bias of 0.025 to 1 V and 0.01 to 1 mA was applied, no oxygen or hydrogen was generated, and cell migration and cell proliferation were promoted within the hydrogel sheet as an electrical stimulation mode.

[0068] In the present invention, the DC bias may be such that hydrogen is generated at the negative electrode when a DC bias of 1.5 to 2.99 V and 2 mA or less is applied.

[0069] In one embodiment of the present invention, hydrogen was generated at the negative electrode when a DC electric bias of 1.5 to 2.99 V and 2 mA or less was applied, and wound healing was promoted.

[0070] In addition, in one embodiment of the present invention, by using a half-bridge (H-bridge) circuit or a DPDT (Double Pole, Double Throw) switch, opposite polarity is applied to Pt and carbon fiber to selectively generate H2 at the Pt electrode.

[0071] In the present invention, the DC bias may be such that oxygen or hydrogen is generated at the positive electrode and negative electrode portions when a DC bias of 3 to 5 V and 2 mA or less is applied.

[0072] In one embodiment of the present invention, when a DC electric bias of 3 to 5 V and 2 mA or less is applied, oxygen or hydrogen is generated at the positive electrode and negative electrode portions as an oxygen or hydrogen generation mode, maintaining the pH within the hydrogel sheet and promoting wound healing.

[0073] The above oxygen generation mode can function to lower the pH within the hydrogel sheet to pH 7 or lower.

[0074] The above hydrogen generation mode can act to raise the pH within the hydrogel sheet to pH 7 or higher.

[0075] Another aspect of the present invention is a method for manufacturing an electronic wound dressing for wound healing, comprising the step of placing a microelectrode that generates oxygen or hydrogen in a microelectrode array.

[0076] Another aspect of the present invention relates to a method for treating a wound using an electronic wound dressing for wound healing, comprising a sheet; and a microelectrode wire array disposed on the upper surface or inside of the sheet.

[0077] In the present invention, the method for treating the wound

[0078] A step of attaching the above electronic wound dressing to a wound site; and

[0079] It may include a step of controlling the pH of the wound site by controlling the amount of oxygen or hydrogen generated by adjusting the DC electric bias applied to the microelectrode wire array in response to pH changes or infection conditions caused by exudate occurring at the wound site.

[0080] In the present invention, the step of adjusting the pH may involve maintaining a pH environment optimized for wound healing by generating hydrogen from the micro-cathode to raise the pH when the wound site becomes acidic and generating oxygen from the micro-anode to lower the pH when the wound site becomes alkaline, but is not limited thereto.

[0081] In the present invention, the DC electric bias control is

[0082] Depending on the above wound healing stage, one or more steps comprising: a step of forming an electric field by applying a bias of 0.025 to 1 V; a step of selectively generating hydrogen by applying a bias of 1.5 to 2.99 V; and a step of simultaneously generating oxygen and hydrogen by applying a bias of 3 to 5 V may be performed, but are not limited thereto.

[0083] In the present invention, the wound may be one or more selected from the group consisting of bedsores, burns, trauma, skin diseases, abrasions, contusions, lacerations, cuts caused by a blade, and chronic wounds caused by diabetic ulcers, but is not limited thereto.

[0084] The present invention relates to an electronic wound dressing for wound healing and a method for manufacturing the same. The electronic wound dressing of the present invention includes an anode and cathode microelectrode array that generates oxygen or hydrogen when an external power source is applied to the wound dressing, and has excellent effects of supplying oxygen to the wound site, decomposing exudate generated from the wound, and alleviating anti-inflammatory effects through hydrogen generation. In addition, the electronic wound dressing of the present invention has a significant effect in promoting cell regeneration and angiogenesis by controlling the spacing between the electrodes when an external power source is applied, thereby generating an electric field and moving cells toward the cathode with the generated electric field.

[0085] Figure 1 is a diagram showing a circuit diagram of an electronic wound dressing.

[0086] Figure 2 is a figure showing the arrangement of two electrodes acting as positive and negative electrodes on a wound dressing foam or dressing.

[0087] Figure 3 shows the experimental results of a hydrogen oxygen generating electrode to be applied to a multifunctional electronic wound dressing.

[0088] Figure 4 is a figure showing the generation of gas at the anode electrode due to PBS decomposition when PBS is used after placing Pt at the anode and Pd at the cathode on a hydrogel sheet.

[0089] Figure 5 is a figure showing the generation of gas at the anode electrode due to PBS decomposition when PBS is used after placing Pt at the anode and carbon fibers at the cathode.

[0090] Hereinafter, embodiments of the present invention are described in detail so that those skilled in the art can easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Since embodiments according to the concept of the present invention may be subject to various modifications and may take various forms, embodiments are illustrated in the drawings and described in detail in this specification. However, this is not intended to limit embodiments according to the concept of the present invention to a specific disclosed form, and includes modifications, equivalents, or substitutions that fall within the spirit and scope of the present invention.

[0091] Throughout this specification, when a part is described as 'comprising' a certain component, it means that, unless specifically stated otherwise, it does not exclude other components but may include additional components. Furthermore, throughout this specification, the singular form includes the plural form unless specifically stated otherwise.

[0092] When a range of numerical values ​​is described in this specification, unless a specific range is otherwise described, the value has the precision of significant figures provided according to the standard rules in chemistry for significant figures. For example, 10 includes a range of 5.0 to 14.9, and the number 10.0 includes a range of 9.50 to 10.49.

[0093] Hereinafter, a method for manufacturing an electronic wound dressing according to one embodiment is described.

[0094] Figure 1 shows a circuit diagram of an electronic wound dressing. It comprises a power supply unit that supplies power and a Microcontroller Unit (MCU) that controls the logic. By connecting it to a DC bias to supply a continuous DC voltage, and using positive and negative electrode materials in a microelectrode wire array, O2 can be generated at the positive electrode and H2 at the negative electrode. The DC bias is a static voltage that does not change over time and can maintain a constant voltage. Additionally, there is a sensor unit that senses the pH concentration or temperature on the hydrogel sheet, which can provide information regarding the pH concentration or temperature to the MCU.

[0095] Microelectrodes for anodes and cathodes that generate O2 / H2 are placed in a foam for wound dressings and function to supply oxygen and hydrogen to the wound site evenly or asymmetrically according to the desired wound, or to generate uniform (symmetric) and asymmetric electric fields.

[0096] Specifically, to generate O2 / H2, the DC bias can be controlled within a voltage of +2.8 V to 5 V and a current range of 1 mA to 5 mA, and for safety, a current of 2 mA or less can be used, and the current range can be appropriately adjusted to limit excessive oxygen and hydrogen generation.

[0097] When power is applied to the electrodes, the electric field generated between the two electrodes causes cell migration (e.g., migration of fibroblasts) towards the cathode due to the polarization of cells present in the electric field and the electro-double layer.

[0098] Figure 2 shows the arrangement of two electrodes acting as positive and negative electrodes on a wound dressing foam or dressing. For example, the left side shows electrodes formed with the structure of an interdigitated electrode (IDE), and the right side shows electrodes formed with the structure of a spiral electrode (SDE). Cell migration occurs towards the negative electrode, and the wound shape can be arranged to allow cells to migrate to the center of the wound by forming electrodes with interdigitated electrode (IDE), side-by-side electrode (SDE), concentric ring electrode, spiral, or fractal electrode pattern structures, for example, by fabricating a spiral electrode structure in a circular shape.

[0099] Figure 3 shows the experimental results of a hydrogen oxygen generating electrode to be applied to a multifunctional electronic wound dressing.

[0100] In 3-A, a wire (Pd wire) formed from palladium (Pd) material was placed parallel to the anode and cathode, and when physiological saline solution pH 7.4 was immersed as the electrolyte, it was confirmed that H2 was generated at the cathode. However, at the anode electrode, a byproduct (CuCl2) was generated, causing the entire electrolyte to become alkaline and the Pd wire to corrode.

[0101] In 3-B, when CuOx / Cu was placed as the anode material and Pd was placed as the cathode and the same electrolyte was used, H2 was generated at the cathode but a byproduct (CuOx) was generated, and the electrolyte likewise changed to alkaline.

[0102] In 3-C, it was confirmed that when Pt was placed at the anode and Pd at the cathode, O2 was produced at the anode electrode and H2 was produced at the cathode electrode, and it was also confirmed that the electrolyte maintained a neutral state with no change.

[0103] Figure 4 shows that when Pt is placed on the anode and Pd on the cathode of a hydrogel sheet and PBS (Phosphate-Buttered Salines) is used, O2 is produced at the anode electrode and H2 is produced at the cathode electrode due to PBS decomposition.

[0104] Figure 5 shows that when Pt is placed at the anode and a carbon fiber at the cathode and PBS is used, O2 is generated at the anode electrode, while no gas is generated from the carbon fiber. Through this, it was confirmed that the PBS solution is acidified by the O2 generated from the Pt fiber. Additionally, by using an H-bridge circuit or a DPDT switch, opposite polarity can be applied to the Pt and the carbon fiber to selectively generate H2 at the Pt electrode.

Claims

1. A sheet; an electronic wound dressing for wound healing comprising a microelectrode wire array disposed on the upper surface or inside of the sheet, The above microelectrode wire array includes one or more micro positive electrodes and one or more micro negative electrodes, and An electronic wound dressing, wherein the above-mentioned one or more micro-positive electrodes and the above-mentioned one or more micro-negative electrodes react to applied electricity to generate one or more selected from the group consisting of oxygen and hydrogen from an environment in which exudate is present.

2. In Paragraph 1, The above-described microelectrode wire array is formed in a structure of an interdigitated electrode (IDE), a side-by-side electrode (SDE), a concentric ring electrode, a spiral, or a fractal electrode pattern, and is an electronic wound dressing.

3. In Paragraph 1, The above-mentioned oxygen-generating microelectrode A micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides. An electronic wound dressing comprising, as a microcathode, one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene, activated carbon / carbon black, metal-organic framework (MOF) derived carbon, nitrogen-doped carbon, molybdenum disulfide (MoS2), and nickel-molybdenum alloy (NiMo alloy).

4. In Paragraph 1, The above-mentioned microelectrode that generates hydrogen is A micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides. An electronic wound dressing comprising, as a microcathode, one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene and activated carbon / carbon black, metal-organic framework (MOF) derived carbon, nitrogen-doped carbon, molybdenum disulfide (MoS2) and nickel-molybdenum alloy (NiMo alloy).

5. In Paragraph 1, The microelectrode that generates the above oxygen and hydrogen is A micro-anode comprises one or more selected from the group consisting of platinum dioxide (PtO2), iridium oxide (IrOx), manganese oxide (Mn2O3), ruthenium dioxide (RuO2), cobalt oxide (Co3O4), nickel oxide (NiOx), rhodium dioxide (RhO2), platinum-iridium (PtIr), iridium-tungsten (IrW), nickel-iron dihydroxide (NiFe LDH), and perovskite-type oxides. An electronic wound dressing comprising, as a microcathode, one or more selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), silver (Ag), copper (Cu), ruthenium (Ru), cobalt (Co), nickel (Ni), rhodium (Rh), carbon fiber, carbon nanotube (CNT), graphene and activated carbon / carbon black, metal-organic framework (MOF) derived carbon, nitrogen-doped carbon, molybdenum disulfide (MoS2) and nickel-molybdenum alloy (NiMo alloy).

6. In Paragraph 1, The above-described microelectrode wire array forms an electric field between a micro-anode and a micro-cathode, an electronic wound dressing.

7. In Paragraph 6, An electronic wound dressing, wherein the electric field formed between the micro-anode and the micro-cathode is formed without generating oxygen or hydrogen when a direct current electric bias of 0.025 to 1 V and 0.01 to 1 mA or less is applied.

8. In Paragraph 6, The above micro-cathode is an electronic wound dressing in which hydrogen is generated at the cathode electrode portion when a DC electric bias of 1.5 to 2.99 V and 2 mA or less is applied.

9. In Paragraph 6, The above micro-anode and micro-cathode are electronic wound dressings in which oxygen or hydrogen is generated at the anode electrode and cathode electrode portions when a DC electric bias of 3 to 5 V and 2 mA or less is applied.

10. In Paragraph 1, The above sheet is an electronic wound dressing formed from one or more materials selected from the group consisting of hydrogel, polyurethane foam, alginate, chitosan, silicone-based wound dressing, cellulose-based materials, and polyvinyl alcohol (PVA) hydrogel.

11. In Paragraph 1, The above sheet is a release layer laminated on the upper surface of the attachment layer, An absorption layer laminated on the other upper surface of the above-mentioned attachment layer, and An electronic wound dressing comprising a release layer laminated on the other upper surface of the absorption layer.

12. In Paragraph 11, The above-described microelectrode wire array is disposed between the attachment layer and the absorption layer, wherein the absorption layer absorbs one or more selected from the group consisting of oxygen and hydrogen generated from the microelectrode, an electronic wound dressing.

13. An electric wound dressing kit comprising an electronic wound dressing according to any one of claims 1 to 11.

14. In Paragraph 13, The above electronic wound dressing kit further comprises a power supply unit, a sensor unit, and a control unit.

15. A method for manufacturing an electronic wound dressing for wound healing, comprising the step of placing a microelectrode that generates oxygen or hydrogen in a microelectrode array according to any one of claims 1 to 11.

16. A method for treating a wound using an electronic wound dressing according to any one of paragraphs 1 to 11, wherein A step of attaching the above electronic wound dressing to a wound site; and A method for treating a wound, comprising the step of controlling the pH of a wound site by controlling the amount of oxygen or hydrogen generated by adjusting the direct current electric bias applied to the microelectrode wire array in response to a change in pH or an infection state caused by exudate occurring at the wound site.

17. In Paragraph 16, A method for treating a wound, wherein the step of adjusting the pH above is to maintain a pH environment optimized for wound healing by generating hydrogen from the micro-cathode to raise the pH when the wound site becomes acidic, and generating oxygen from the micro-anode to lower the pH when the wound site becomes alkaline.

18. In Paragraph 16, The above DC electric bias control is A method for treating a wound, comprising performing one or more steps among the steps of: forming an electric field by applying a bias of 0.025 to 1 V according to the wound healing stage; selectively generating hydrogen by applying a bias of 1.5 to 2.99 V; and simultaneously generating oxygen and hydrogen by applying a bias of 3 to 5 V.

19. In Paragraph 16, A method for treating a wound, wherein the above wound is one or more selected from the group consisting of bedsores, burns, trauma, skin diseases, abrasions, contusions, lacerations, cuts caused by a blade, and chronic wounds caused by diabetic ulcers.

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