Systems and methods for autologous regeneration of tissue

The handheld skin grafting system addresses donor site damage and inefficiencies by using a drive system with hollow microneedles and feedback mechanisms for precise skin harvesting and scattering, improving wound coverage and healing.

WO2026156248A1PCT designated stage Publication Date: 2026-07-23MEDLINE INDUSTRIES
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
MEDLINE INDUSTRIES
Filing Date
2026-01-16
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Conventional skin grafting systems cause significant donor site damage and are limited by the availability and suitability of donor sites, leading to issues such as scarring, extended healing times, and inefficiencies in covering large wound areas.

Method used

A handheld skin grafting system with a drive system, hollow microneedles, and a feedback system for harvesting and scattering skin microcolumns, utilizing a cartridge with a rotation mechanism and ultrasonic actuation for precise tissue harvesting and stabilization, along with a user interface for real-time feedback.

Benefits of technology

The system minimizes donor site damage, allows for efficient harvesting of skin microcolumns, and facilitates rapid wound coverage with reduced scarring and improved healing times, enhancing the autologous regeneration of skin tissue.

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Abstract

A system can include a plurality of hollow tubes, each hollow tube can be configured to harvest a respective tissue portion from a tissue site. The respective tissue portion can include skin tissue. The system can include an actuation system configured to translate the plurality of hollow tubes simultaneously into the tissue site. The system can include a rotational drive configured to rotate each hollow tube of the plurality of tubes. In some embodiments, as the actuation system translates the plurality of hollow tubes into the tissue site, the rotational drive can be configured to rotate each hollow tube of the plurality of hollow tubes, or after the actuation system translates the plurality of hollow tubes into the tissue site, the rotational drive can be configured to rotate each hollow tube of the plurality of hollow tubes to ensure each tissue portion is severed from the tissue site.
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