Workflows for tissue staining with rapid laser heating

The laser-based heating system addresses the inefficiencies of traditional methods by rapidly processing slides, enhancing tissue staining efficiency and reliability through direct heating, thus reducing processing times and energy use.

WO2026156255A1PCT designated stage Publication Date: 2026-07-23VENTANA MEDICAL SYSTEMS INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
VENTANA MEDICAL SYSTEMS INC
Filing Date
2026-01-16
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

The traditional tissue staining process for histological pathology diagnosis is laborious and time-consuming due to slow heating methods like thermal conduction and convection ovens, which require significant processing times and can lead to inadequate staining and tissue damage.

Method used

A laser-based heating system that directly heats microscope slides using a carbon dioxide laser, allowing for rapid baking, dewaxing, and curing processes, reducing processing times to approximately 30 to 300 seconds and minimizing energy consumption.

Benefits of technology

The laser-based system significantly reduces processing times and energy consumption while ensuring accurate and reliable tissue staining, aligning with advanced staining processes and reducing the risk of tissue damage.

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Abstract

A unique system and method for preparing tissue samples on slides for microscopic analysis has been developed. The system uses a laser to directly heat slides during various processing stages, including baking, dewaxing, and curing. The laser is controlled to target specific areas of the slide, such as the bottom surface of the slide or coverslip, to promote efficient heating while protecting the tissue sample. Temperature sensors and feedback control help manage the heating process. The system can include modules for dispensing solvents and removing wax, as well as features for applying and curing coverslips. Tills approach reduces processing time and energy use compared to traditional oven and resistive heating methods.
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