Ophthalmic product and ophthalmic liquid composition

Abstract

An ophthalmic product and an ophthalmic liquid composition. The ophthalmic liquid composition comprises at least β-glucan, and optionally comprises at least one of a hydrophilic polymer, a surfactant and a buffering agent. β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan. On the basis of the total weight of the ophthalmic liquid composition being 100 wt%, the content of β-glucan is in the range of 0.003-3 wt%. When a contact lens is soaked in the ophthalmic liquid composition, the β-glucan forms a polymer matrix film on the surface of the contact lens to slow down water evaporation on the surface of the lens.

Description

Ophthalmic products and ophthalmic liquid compositions Technical Field

[0001] This disclosure relates to an ophthalmic product, and more particularly to an ophthalmic product and an ophthalmic liquid composition. Background Technology

[0002] In existing technologies, contact lens preservation solutions typically use a combination of buffers to preserve contact lenses. However, while the components in these compositions can preserve contact lenses, prolonged wear after removal can easily lead to moisture loss and cause dry eyes.

[0003] Therefore, a common challenge in existing technologies is designing stable and efficient preservation solution formulations that can effectively slow down moisture evaporation from the contact lens surface, prolong hydration time, and improve wearing comfort, thereby meeting the needs of long-term use. Solving this problem requires developing an innovative composition formulation that offers higher stability, longer-lasting moisturizing effects, and the ability to maintain lens hydration in various environments. Summary of the Invention

[0004] The technical problem to be solved by this disclosure is to provide an ophthalmic product and an ophthalmic liquid composition that address the shortcomings of the prior art.

[0005] To address the aforementioned technical problems, one technical solution adopted in this disclosure is to provide an ophthalmic product comprising: an ophthalmic liquid composition; and a contact lens immersed in the ophthalmic liquid composition; wherein the ophthalmic liquid composition comprises at least:

[0006] (a) β-glucan; and selectively includes at least one of (b) to (d):

[0007] (b) Hydrophilic polymers;

[0008] (c) Surfactants; and

[0009] (d) Buffer;

[0010] The β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan; the content of β-glucan is between 0.003% and 3% by weight, based on a total weight of 100% of the ophthalmic liquid composition; the β-glucan forms a polymeric matrix film on the surface of the contact lens, and the polymeric matrix film slows down the evaporation of moisture from the lens surface.

[0011] Preferably, the number average molecular weight (Mn) of the β-glucan is between 1 kDa and 4,000 kDa.

[0012] Preferably, the surfactant content is between 0.001 wt% and 5 wt%, the hydrophilic polymer content is between 0.01 wt% and 5 wt%, and the buffer content is between 0.01 wt% and 5 wt%.

[0013] Preferably, the content of the β-glucan is between 0.003% by weight and 1% by weight, the content of the hydrophilic polymer is between 0.01% by weight and 1% by weight, the content of the surfactant is between 0.003% by weight and 1% by weight, and the content of the buffer is between 0.1% by weight and 5% by weight.

[0014] Preferably, the contact lens undergoes an atmospheric dehydration test at an environment of 20°C to 25°C and a relative humidity of 50% to 65% RH, and the percentage of water loss of the contact lens after 10 minutes is no more than 0.14%.

[0015] Preferably, the ophthalmic liquid composition further comprises: a functional additive, and the content of the functional additive is between 0.00001% by weight and 5% by weight.

[0016] Preferably, the hydrophilic polymer is at least one of the group consisting of the following materials: sodium γ-polyglutamate (γ-PGA), hyaluronic acid (HA), polyethylene glycol (PEG), poly(2-methacryloyloxyethylphosphorylcholine) (PMPC), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), polyvinyl alcohol (PVA), and polyaspartic acid (PAS).

[0017] Preferably, the hydrophilic polymer comprises: sodium γ-polyglutamate (γ-PGA) and polyethylene glycol (PEG).

[0018] Preferably, the surfactant is selected from at least one of the group consisting of: polysorbate, polyoxypropylene glycol, polyoxyethylene glycol, sorbitan oleate, sorbitan monolaurate, sorbitan tristearate, sodium lauryl sulfate, sodium lauryl ether sulfate, alkyl sulfosuccinate, monooctyl sulfosuccinate, dioctyl sulfosuccinate, sodium dioctyl sulfosuccinate, glyceryl monostearate, and ethylene oxide copolymer of styrene.

[0019] Preferably, the functional additive is selected from at least one of the group consisting of xanthine and its derivatives, terpenoids, and vitamins.

[0020] Preferably, xanthine and its derivatives include at least one of xanthine, caffeine, paraxanthine, theobromine, and theophylline; terpenoids include at least one of menthol, camphor, borneol, menthyl lactate, menthone-glycerol ketal, monomethyl succinate, and p-menthane-3,8-diol; and vitamins include at least one of vitamin E acetate, riboflavin, pyridoxine, cobalamin, and tocopherol.

[0021] To solve the aforementioned technical problems, another technical solution adopted in this disclosure is to provide an ophthalmic liquid composition comprising at least: (a) β-glucan; and selectively including at least one of (b) to (d): (b) a hydrophilic polymer; (c) a surfactant; and (d) a buffer; wherein the β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan; wherein, based on a total weight of 100% by weight of the ophthalmic liquid composition, the content of the β-glucan is between 0.003% by weight and 3% by weight; wherein, when the ophthalmic liquid composition is used to soak a contact lens, the β-glucan can form a polymeric matrix film on the surface of the contact lens, and the polymeric matrix film slows down the evaporation of moisture from the lens surface. Preferably, the number average molecular weight (Mn) of the β-glucan is between 1 kDa and 4,000 kDa.

[0022] Preferably, the content of the surfactant is between 0.001 wt% and 5 wt%, the content of the hydrophilic polymer is between 0.01 wt% and 5 wt%, and the content of the buffer is between 0.01 wt% and 5 wt%.

[0023] Preferably, the content of the β-glucan is between 0.003% by weight and 1% by weight, the content of the hydrophilic polymer is between 0.01% by weight and 1% by weight, the content of the surfactant is between 0.003% by weight and 1% by weight, and the content of the buffer is between 0.1% by weight and 5% by weight.

[0024] Preferably, the ophthalmic liquid composition further comprises: a functional additive, and the content of the functional additive is between 0.00001% by weight and 5% by weight.

[0025] Preferably, the hydrophilic polymer is selected from at least one of the group consisting of: sodium γ-polyglutamate (γ-PGA), hyaluronic acid (HA), polyethylene glycol (PEG), poly(2-methacryloyloxyethylphosphorylcholine) (PMPC), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), polyvinyl alcohol (PVA), and polyaspartic acid (PAS).

[0026] Preferably, the hydrophilic polymer comprises: sodium γ-polyglutamate (γ-PGA) and polyethylene glycol (PEG).

[0027] Preferably, the surfactant is selected from at least one of the group consisting of: polysorbate, polyoxypropylene glycol, polyoxyethylene glycol, sorbitan oleate, sorbitan monolaurate, sorbitan tristearate, sodium lauryl sulfate, sodium lauryl ether sulfate, alkyl sulfosuccinate, monooctyl sulfosuccinate, dioctyl sulfosuccinate, sodium dioctyl sulfosuccinate, glyceryl monostearate, and ethylene oxide copolymer of styrene.

[0028] Preferably, the functional additive is selected from at least one of the group consisting of xanthine and its derivatives, terpenoids, and vitamins.

[0029] The beneficial effects of this disclosure are that the ophthalmic products and ophthalmic liquid compositions provided by this disclosure, through the technical solutions of "the ophthalmic liquid composition includes at least β-glucan, said β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan" and "based on the total weight of said ophthalmic liquid composition being 100% by weight, the content of said β-glucan is between 0.003% by weight and 3% by weight", so that when said ophthalmic liquid composition is soaked in contact lenses, said β-glucan can not only exert multiple functions such as antioxidant, anti-allergic, anti-inflammatory and wound healing promotion, but also give the surface of contact lenses excellent moisturizing properties. Detailed Implementation

[0030] The following specific embodiments illustrate the implementation methods disclosed herein. Those skilled in the art can understand the advantages and effects of this disclosure from the content disclosed in this specification. This disclosure can be implemented or applied through other different specific embodiments, and various details in this specification can also be modified and changed based on different viewpoints and applications without departing from the concept of this disclosure.

[0031] It should be understood that while terms such as “first,” “second,” and “third” may be used in this document to describe various materials or parameters, these materials or parameters should not be limited by these terms. These terms are primarily used to distinguish one material from another, or one parameter from another. Furthermore, the term “or” as used in this document should, as appropriate, include any combination of one or more related items listed.

[0032] [First Embodiment]

[0033] This disclosure provides an ophthalmic product comprising an ophthalmic liquid composition and a contact lens immersed in the ophthalmic liquid composition. This disclosure also provides an ophthalmic liquid composition for immersing contact lenses.

[0034] The ophthalmic liquid composition of this disclosure can effectively slow down the evaporation of moisture on the surface of contact lenses, significantly prolonging the wetting time of the contact lens surface, making the eyes less prone to dryness while correcting vision.

[0035] To achieve the above objectives, the ophthalmic liquid composition comprises at least:

[0036] (a) beta-glucan; and the ophthalmic liquid composition selectively comprises at least one of components (b) to (e):

[0037] (b) Hydrophilic polymers;

[0038] (c) Surfactant;

[0039] (d) Buffering agent; and

[0040] (e) Functional additives.

[0041] Based on the total weight of the ophthalmic liquid composition being 100% by weight, the content of each component is as follows.

[0042] The β-glucan(a) content is between 0.003 wt% and 3 wt%, optionally between 0.003 wt% and 1 wt%, and particularly preferably between 0.003 wt% and 0.05 wt%.

[0043] The content of the hydrophilic polymer (b) is between 0.01 wt% and 5 wt%, optionally between 0.01 wt% and 1 wt%, and particularly preferably between 0.01 wt% and 0.5 wt%.

[0044] The surfactant (c) content is between 0.001 wt% and 5 wt%, optionally between 0.003 wt% and 1 wt%, and particularly preferably between 0.005 wt% and 0.2 wt%.

[0045] The content of the buffer (d) is between 0.01% by weight and 5% by weight, optionally between 0.1% by weight and 5% by weight, and particularly preferably between 0.5% by weight and 1.5% by weight.

[0046] The content of the functional additive (e) is between 0.00001 wt% and 5 wt%, optionally between 0.0001 wt% and 4 wt%, and particularly preferably between 0.001 wt% and 3 wt%.

[0047] The ophthalmic liquid composition further comprises an equal amount of water.

[0048] In this embodiment, the pH value of the ophthalmic liquid composition is between 6.0 and 8.0, and the osmotic pressure is between 250 Osmol / Kg and 380 Osmol / Kg, but this disclosure is not limited thereto.

[0049] Furthermore, when the ophthalmic liquid composition is used to soak the contact lens, the β-glucan forms a polymeric matrix film on the surface of the contact lens. This polymeric matrix film helps to slow down the evaporation of moisture from the contact lens surface, significantly prolonging the wetting time of the contact lens surface.

[0050] Specifically, the β-glucan adheres to the contact lens through hydrogen bonding between the numerous hydroxyl groups dispersed on its polymer chain and the surface material of the contact lens, thereby forming the polymer matrix film.

[0051] In one embodiment of this disclosure, when the ophthalmic liquid composition is immersed in and moist heat sterilized at a temperature of 20°C to 30°C for at least 30 minutes, the β-glucan forms a polymer matrix film with a thickness of 0.005 μm to 10 μm on the outer surface of the contact lens, but this disclosure is not limited thereto. More specifically, the lens can be placed together with the liquid composition in a packaging container (such as a sealable 5 mL glass Vial bottle or a sealed PP cup) for moist heat sterilization for 30 minutes. After the sample returns to room temperature, a contact lens with a polymer matrix film of β-glucan on its surface can be obtained.

[0052] In this embodiment, the β-glucan can be an extract derived from fungi, specifically a component extracted from fungal polysaccharides (such as Ganoderma lucidum). Furthermore, the β-glucan possesses a polymeric helical structure of β-1,3 / 1,6-D-glucan, which imparts excellent moisturizing properties to the surface of contact lenses, while also exhibiting multiple functionalities such as antioxidant, anti-allergic, anti-inflammatory, and wound-healing properties. In particular, fungal-derived β-glucan has a significant effect on promoting wound healing, and therefore can be used to improve the wearing comfort and stability of contact lenses.

[0053] It is worth noting that, as mentioned above, a β-glucan content between 0.003% and 3% by weight is more conducive to the formation of a continuous polymer matrix film on the surface of contact lenses. If the β-glucan content is too low (e.g., below 0.003% by weight), the β-glucan may not be able to form a polymer matrix film on the lens surface, thus failing to help slow down the evaporation of moisture from the contact lens surface. Conversely, if the β-glucan content is too high (e.g., above 3% by weight), the β-glucan may make the ophthalmic liquid composition too viscous, making it unsuitable for product applications (e.g., contact lens preservation solutions).

[0054] Furthermore, in one embodiment of this disclosure, the number average molecular weight (Mn) of the β-glucan is between 1 kDa and 4,000 kDa, optionally between 1 kDa and 1,000 kDa, particularly preferably between 1 kDa and 200 kDa, and even more preferably between 5 kDa and 30 kDa. The number average molecular weight is determined by gel permeation chromatography (GPC).

[0055] It should be noted that the molecular weight of β-glucan in this range is more conducive to its dissolution or dispersion in ophthalmic liquid compositions and to the formation of a polymer matrix film on the surface of contact lenses.

[0056] If the average molecular weight of β-glucan is below the lower limit mentioned above (e.g., below 1 kDa), β-glucan is difficult to adhere effectively to the surface of contact lenses. Furthermore, if the average molecular weight of β-glucan is above the upper limit mentioned above (e.g., exceeding 4,000 kDa), the solubility or dispersibility of β-glucan molecules in ophthalmic liquid compositions is poor, making them unsuitable for use in contact lens preservation solutions.

[0057] Therefore, the β-glucan in this embodiment is selected in the range of number average molecular weight from 1 kDa to 4,000 kDa to ensure that the β-glucan can be stably dispersed in the ophthalmic liquid composition during use and form a continuous polymer matrix film on the surface of the contact lens, which helps to slow down moisture evaporation.

[0058] Furthermore, the hydrophilic polymer (i.e., component (b)) is at least one of the group consisting of the following materials: sodium γ-polyglutamic acid (γ-PGA), hyaluronic acid (HA), polyethylene glycol (PEG), poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), polyvinyl alcohol (PVA), and polyaspartic acid (PAS).

[0059] The β-glucan (i.e., component (a)) can synergistically work with the hydrophilic polymer (i.e., component (b)) to enhance the moisturizing properties of contact lenses.

[0060] The surfactant (i.e., component (c)) is selected from at least one of the group consisting of: polysorbate (PS), polyoxypropylene glycol (PPG), polyoxyethylene glycol (PEG), sorbitan oleate (SO), sorbitan monolaurate (SML), sorbitan triisostearate (STI), sodium lauryl sulfate (SLS), sodium lauryl ether sulfate (SLES), alkyl sulfosuccinate (AS), sodium octyl sulfosuccinate (SOS), dioctyl sulfosuccinate (DOS), sodium dioctyl sulfosuccinate (DOS). Sulfosuccinate (DOSS, such as Geropon SBFA-30), glycerol monostearate (GMS), and styrene ethylene oxide copolymer (SEC).

[0061] Optionally, the surfactant is selected from polysorbates, and the polysorbate is at least one of polysorbate 20 (PS-20), polysorbate 40 (PS-40), polysorbate 60 (PS-60), and polysorbate 80 (PS-80). Particularly preferred is polysorbate 80, but this disclosure is not limited thereto.

[0062] The surfactant is used to help lubricate the surface of the contact lens, reducing friction between the lens and the user's eye cells.

[0063] In addition, the surfactant can ensure that the components in the ophthalmic liquid composition (preservation solution) are uniformly and stably dispersed, avoiding phase separation or uneven composition, and ensuring the consistency of the effect of the contact lens preservation solution during use.

[0064] The buffer (i.e., component (d)) is a borate buffer or a phosphate buffer.

[0065] The borate buffer comprises at least one of the following: sodium chloride, boric acid, sodium borate, sodium tetraborate, and sodium metaborate.

[0066] The phosphate buffer comprises at least one of the following: sodium chloride, sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, sodium phosphate, and sodium tripolyphosphate.

[0067] By selecting appropriate combinations of buffers, the pH and osmotic pressure of ophthalmic liquid compositions can be adjusted, thereby improving their stability and safety. Additionally, buffers ensure isotonicity between the lens and the tear film on the ocular surface, reducing wearing discomfort.

[0068] The functional additive (i.e., component (e)) is selected from at least one of the group consisting of xanthine and its derivatives, terpenoids, and vitamins.

[0069] Xanthine and its derivatives may include, but are not limited to, at least one of xanthine, caffeine, paraxanthine, theobromine, and theophylline.

[0070] Terpenoids may include, but are not limited to, at least one of menthol, camphor, borneol, menthyl lactate, menthone-glycerol ketal, monomethyl succinate, and p-menthane-3,8-Diol.

[0071] Vitamins may include, but are not limited to, at least one of vitamin E acetate, vitamin B2 (Riboflavin), vitamin B6 (Pyridoxine), vitamin B12 (Cobalamin), and vitamin E (Tocopherol).

[0072] By combining these functional additives, the composition can be endowed with physiological effects that promote the metabolism and repair of ocular surface cells, thereby improving the comfort and protective effect of liquid contact lens compositions in long-term wearing situations.

[0073] Meanwhile, when the β-glucan is absorbed by the ocular surface cells, it can further exert its moisturizing effects such as anti-oxidation, anti-allergy, anti-inflammation and corneal repair. When β-glucan is combined with B vitamins, it can effectively improve the metabolism of ocular surface cells and relieve eye fatigue. When these ingredients work together, they can maximize the comfort of wearing contact lenses.

[0074] [Experimental Data and Test Results]

[0075] To demonstrate that the ophthalmic liquid composition disclosed herein has an optional moisturizing effect on contact lenses, effectively slows down the evaporation of moisture from the surface of contact lenses, and significantly prolongs the wetting time of the contact lens surface, the following explanation of relevant experimental data and test results is provided.

[0076] [Experimental Example 1 and Control Example 1]

[0077] The ophthalmic liquid composition (contact lens preservation solution) was prepared according to the formulations in Table 1-1 below. Test Example 1 is a preservation solution containing buffers, β-glucan (β-1,3 / 1,6-D-glucan, Mn-10-15kDa), and hydrophilic polymers (i.e., the formulation of the embodiments of this disclosure). Control Example 1 is a preservation solution containing only buffers, without the addition of β-glucan and other components such as hydrophilic polymers.

[0078] [Table 1-1]

[0079] Then, the lens moisture evaporation (atmospheric dehydration rate) of Test Example 1 and Control Example 1 were tested. The test method was to place two sets of contact lenses (e.g., colored contact lenses with 38% water content, made of Polymacon) in the preservation solution of Test Example 1 and Control Example 1, seal them, and sterilize them at high temperature (e.g., 125°C) for at least 30 minutes.

[0080] Test steps: (1) Remove the lens from the preservation solution and place it in an environment of 23.8℃ and 59.8% RH (relative humidity). (2) Measure the evaporation of water on the lens surface every 1 minute for a total of 10 minutes. (3) Record the measured percentage of water loss (Water Loss, %) as data, and the results are shown in Table 1-2 below.

[0081] [Table 1-2]

[0082] The results show that the water evaporation rate of Test Example 1 is significantly lower than that of Control Example 1. The water loss of Test Example 1 at 10 minutes was only 0.061%, while that of Control Example 1 was 0.071%. This result shows that the β-glucan added to the composition of this disclosure can effectively slow down water evaporation, improve the moisturizing effect of the lens surface and the wearing stability.

[0083] [Experimental Example 2 and Control Example 2]

[0084] The ophthalmic liquid composition (contact lens preservation solution) was prepared according to the formulations in Table 2-1 below. Example 2 is a preservation solution containing buffers, β-glucan (β-1,3 / 1,6-D-glucan, Mn-10-15kDa), and hydrophilic polymers (i.e., the formulation of the embodiments disclosed herein). Comparative Example 2 is commercially available Alcon Dailies. Contact lens products.

[0085] [Table 2-1]

[0086] Then, Test Example 2 and Control Example 2 were tested for lens moisture evaporation (atmospheric dehydration rate). The test method was to place a set of contact lenses (e.g., colored contact lenses with 38% water content, made of Polymacon) in the contact lens preservation solution of Test Example 2, seal them, and sterilize them at high temperature (e.g., 125°C) for at least 30 minutes.

[0087] In contrast, Example 2 uses commercially available Alcon Dailies. Contact lens products (including storage solutions and contact lens lenses).

[0088] Test steps: (1) Remove the lens from the preservation solution and place it in an environment of 21°C and 65.0% RH (relative humidity). (2) Measure the evaporation of water on the lens surface every 1 minute for a total of 10 minutes. (3) Record the measured percentage of water loss (Water Loss, %) as data, and the results are shown in Table 2-2 below.

[0089] [Table 2-2]

[0090] The results show that the water evaporation rate of Example 2 was significantly lower than that of Control Example 2. The water loss in Example 2 at 10 minutes was only 0.096%, while the control example showed a loss of 0.121%. This result indicates that the β-glucan added to the composition of this disclosure can effectively slow down water evaporation, improve the moisturizing effect of the lens surface, and enhance wearing stability. It is worth mentioning that the hydrophilic polymers in Example 1, namely γ-polyglutamic acid and polyethylene glycol (400), have a better moisturizing effect than the hyaluronic acid used in Example 2.

[0091] Overall, when the contact lens is removed from the ophthalmic liquid composition of this disclosure, and the contact lens is subjected to an atmospheric dehydration test at an environment of 20°C to 25°C and a relative humidity of 50% to 65% RH, the percentage of water loss of the contact lens of this disclosure after 10 minutes is no greater than 0.14% (optionally no greater than 0.135%, particularly preferably no greater than 0.12%), and is less than the percentage of water loss of the control group that does not contain β-glucan (or only contains a buffer).

[0092] [Experimental Example 3 and Control Example 3]

[0093] The ophthalmic liquid composition (contact lens preservation solution) was prepared according to the formulations in Table 3-1 below. Test Examples 3-1 and 3-2 are preservation solutions (i.e., the formulations of the embodiments of this disclosure) containing buffers, β-glucan (β-1,3 / 1,6-D-glucan, Mn of 10-15 kDa), and hydrophilic polymers, respectively. Comparative Example 3 is commercially available J&J 1-DAY... Contact lens products.

[0094] [Table 3-1]

[0095] Then, the lens moisture evaporation (atmospheric dehydration rate) was tested in Test Example 3-1, Test Example 3-2, and Control Example 3. The test method involved placing two sets of contact lenses (e.g., colored contact lenses with 58% water content, made of Polymacon) in the contact lens preservation solutions of Test Example 3-1 and Test Example 3-2 respectively, sealing them, and sterilizing them at high temperature (e.g., 125°C) for at least 30 minutes.

[0096] In addition, compared with Example 3, the commercially available J&J 1-DAY was used. Contact lens products (including storage solutions and contact lens lenses).

[0097] Test steps: (1) Remove the lens from the preservation solution and place it in an environment of 21°C and 60.2% RH (relative humidity). (2) Measure the evaporation of water on the lens surface every 1 minute for a total of 15 minutes. (3) Record the measured percentage of water loss (Water Loss, %) as data, and the results are shown in Table 3-2 below.

[0098] [Table 3-2]

[0099] The results show that the water evaporation rates of Test Examples 3-1 and 3-2 were significantly lower than those of Control Example 3. At the 10-minute mark, the water loss in Test Examples 3-1 and 3-2 was less than 0.2%, while that in Control Example 3 was greater than 0.2%. These results demonstrate that the β-glucan added to the composition of this disclosure can effectively slow down water evaporation, improve the moisturizing effect of the lens surface, and enhance wearing stability.

[0100] It is worth mentioning that the preservation solution of Experiment 3-2 contained 0.08% β-glucan, which is higher than the 0.02% of Experiment 3-1. The atmospheric dehydration rate of Experiment 3-2 was lower than that of Experiment 3-1 in tests from 1 to 15 minutes. The results show that, within a certain concentration range, the addition of a higher concentration of β-glucan can help slow down the evaporation of moisture from the lens surface.

[0101] [Experimental Example 4 and Control Example 4]

[0102] The ophthalmic liquid composition (contact lens preservation solution) was prepared according to the formulations in Table 4-1 below. Test Example 4 is a preservation solution containing buffers, β-glucan (β-1,3 / 1,6-D-glucan, Mn 10-15kDa), and hydrophilic polymers (i.e., the formulation of the embodiments disclosed herein). Control Example 4 is a commercially available Haichang True Water Daily Disposable Contact Lens product.

[0103] [Table 4-1]

[0104] Subsequently, Test Example 4 and Control Example 4 were tested for lens moisture evaporation (atmospheric dehydration rate). The test method involved placing a set of contact lenses (e.g., colored contact lenses with 38% water content, made of Polymacon) in the contact lens preservation solution of Test Example 4, sealing them, and sterilizing them at high temperature (e.g., 125°C) for at least 30 minutes. Control Example 4 used commercially available Haichang True Water Sensation Daily Disposable Contact Lens products (including preservation solution and contact lenses).

[0105] Test steps: (1) Remove the lens from the preservation solution and place it in an environment of 21.2℃ and 60.0% RH (relative humidity). (2) Measure the evaporation of water on the lens surface every 1 minute for a total of 15 minutes. (3) Record the measured percentage of water loss (Water Loss, %) as data, and the results are shown in Table 4-2 below.

[0106] [Table 4-2]

[0107] The results show that the water evaporation rate of Example 4 was significantly lower than that of Control Example 4. Example 4 showed a water loss of only 0.095% at 10 minutes, while Control Example 4 showed a loss of 0.149%. These results demonstrate that the β-glucan added to the composition of this disclosure is more effective than commercially available products in slowing down water evaporation, improving the moisturizing effect on the lens surface, and enhancing wearing stability.

[0108] In terms of formulation, in one specific embodiment of this disclosure, the buffer (d) of the ophthalmic liquid composition comprises 0.76–0.82 wt% sodium chloride, 0.20–0.28 wt% boric acid, and 0.005–0.015 wt% sodium borate. The content of β-glucan (a) is 0.01–0.1 wt%. The hydrophilic polymer (b) comprises 0.1–0.3 wt% γ-polyglutamic acid and 0.05–0.1 wt% polyethylene glycol. The surfactant (c) is 0.001–0.1 wt% polysorbate 80. The functional additive (e) comprises 0.001–0.01 wt% menthol and 0.001–0.01 wt% vitamin E acetate.

[0109] In another specific embodiment of this disclosure, the buffer (d) of the ophthalmic liquid composition comprises 0.76–0.82 wt% sodium chloride, 0.20–0.28 wt% boric acid, and 0.005–0.015 wt% sodium borate. The content of β-glucan (a) is 0.01–0.1 wt%. The hydrophilic polymer (b) is 0.01–0.15 wt% hyaluronic acid. The surfactant (c) is 0.001–0.15 wt% polysorbate 80. The functional additive (e) comprises 0.001–0.01 wt% menthol, 0.001–0.01 wt% vitamin E acetate, 0.005–0.05 wt% vitamin B12, and 0.1–5 wt% caffeine.

[0110] In another specific embodiment of this disclosure, the buffer (d) of the ophthalmic liquid composition comprises 0.76–0.82 wt% sodium chloride, 0.20–0.28 wt% boric acid, and 0.005–0.015 wt% sodium borate. The content of β-glucan (a) is 0.01–0.1 wt%. The hydrophilic polymer (b) comprises 0.01–0.05 wt% poly(2-methacryloyloxyethylphosphorylcholine) (PMPC) and 0.03–0.08 wt% polyethylene glycol (PEG400). The surfactant (c) is 0.001–0.15 wt% polysorbate 80. The functional additive (e) comprises 0.1–5 wt% caffeine.

[0111] [Beneficial Effects of the Examples]

[0112] The beneficial effects of this disclosure are that the ophthalmic products and ophthalmic liquid compositions provided by this disclosure, through the technical solutions of "the ophthalmic liquid composition includes at least β-glucan, said β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan" and "based on the total weight of said ophthalmic liquid composition being 100% by weight, the content of said β-glucan is between 0.003% by weight and 3% by weight", so that when said ophthalmic liquid composition is soaked in contact lenses, said β-glucan can not only exert multiple functions such as antioxidant, anti-allergic, anti-inflammatory and wound healing promotion, but also give the surface of contact lenses excellent moisturizing properties.

[0113] The above-disclosed content is only an optional and feasible embodiment of this disclosure and is not intended to limit the claims of this disclosure. Therefore, all equivalent technical changes made using the content of this disclosure are included in the claims of this disclosure.

Claims

1. An ophthalmic product, characterized in that, The ophthalmic products include: Ophthalmic liquid composition; and A contact lens, which is immersed in the ophthalmic liquid composition; The ophthalmic liquid composition comprises at least: (a) β-glucan; and selectively includes at least one of (b) to (d): (b) Hydrophilic polymers; (c) Surfactants; and (d) Buffer; The β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan. Wherein, based on the total weight of the ophthalmic liquid composition being 100% by weight, the content of the β-glucan is between 0.003% by weight and 3% by weight; The β-glucan forms a polymer matrix film on the surface of the contact lens, and the polymer matrix film slows down the evaporation of moisture from the lens surface.

2. The ophthalmic product according to claim 1, characterized in that, The number of β-glucans has an average molecular weight between 1 kDa and 4,000 kDa.

3. The ophthalmic product according to claim 1, characterized in that, The surfactant content is between 0.001 wt% and 5 wt%, the hydrophilic polymer content is between 0.01 wt% and 5 wt%, and the buffer content is between 0.01 wt% and 5 wt%.

4. The ophthalmic product according to claim 3, characterized in that, The content of the β-glucan is between 0.003% by weight and 1% by weight, the content of the hydrophilic polymer is between 0.01% by weight and 1% by weight, the content of the surfactant is between 0.003% by weight and 1% by weight, and the content of the buffer is between 0.1% by weight and 5% by weight.

5. The ophthalmic product according to claim 1, characterized in that, The contact lens was subjected to an atmospheric dehydration test at an environment of 20°C to 25°C and relative humidity of 50% to 65%. The percentage of water loss of the contact lens after 10 minutes was no more than 0.14%.

6. The ophthalmic product according to claim 1, characterized in that, The ophthalmic liquid composition further comprises: a functional additive, and the content of the functional additive is between 0.00001% by weight and 5% by weight.

7. The ophthalmic product according to claim 1, characterized in that, The hydrophilic polymer is selected from at least one of the group consisting of the following materials: sodium γ-polyglutamate, hyaluronic acid, polyethylene glycol, poly(2-methacryloyloxyethylphosphorylcholine), polyvinylpyrrolidone, polyacrylic acid, polyvinyl alcohol, and polyaspartic acid.

8. The ophthalmic product according to claim 7, characterized in that, The hydrophilic polymer comprises: sodium γ-polyglutamate and polyethylene glycol.

9. The ophthalmic product according to claim 1, characterized in that, The surfactant is selected from at least one of the group consisting of: polysorbate, polyoxypropylene glycol, polyoxyethylene glycol, sorbitan oleate, sorbitan monolaurate, sorbitan tristearate, sodium lauryl sulfate, sodium lauryl ether sulfate, alkyl sulfosuccinate, monooctyl sulfosuccinate, dioctyl sulfosuccinate, sodium dioctyl sulfosuccinate, glyceryl monostearate, and styrene-ethylene oxide copolymer.

10. The ophthalmic product according to claim 6, characterized in that, The functional additive is selected from at least one of the group consisting of xanthine and its derivatives, terpenoids, and vitamins.

11. The ophthalmic product according to claim 10, characterized in that, Xanthine and its derivatives include at least one of xanthine, caffeine, paraxanthine, theobromine, and theophylline; terpenoids include at least one of menthol, camphor, borneol, menthol lactate, menthone glycerol ketal, menthyl succinate, and p-menthane-3,8-diol; vitamins include at least one of vitamin E acetate, vitamin B2, vitamin B6, vitamin B12, and vitamin E.

12. An ophthalmic liquid composition, characterized in that, The ophthalmic liquid composition comprises at least: (a) β-glucan; and the selectivity includes at least one of (b) to (d): (b) Hydrophilic polymers; (c) Surfactants; and (d) Buffer; The β-glucan is an extract derived from fungi and has a polymeric helical structure of β-1,3 / 1,6-D-glucan; and the content of the β-glucan is between 0.003% and 3% by weight, based on a total weight of 100% of the ophthalmic liquid composition. When the ophthalmic liquid composition is used to soak a contact lens, the β-glucan can form a polymer matrix film on the surface of the contact lens, and the polymer matrix film slows down the evaporation of moisture from the lens surface.

13. The ophthalmic liquid composition according to claim 12, characterized in that, The number average molecular weight of the β-glucan is between 1 kDa and 4,000 kDa.

14. The ophthalmic liquid composition according to claim 12, characterized in that, The surfactant content is between 0.001 wt% and 5 wt%, the hydrophilic polymer content is between 0.01 wt% and 5 wt%, and the buffer content is between 0.01 wt% and 5 wt%.

15. The ophthalmic liquid composition according to claim 14, characterized in that, The content of the β-glucan is between 0.003% by weight and 1% by weight, the content of the hydrophilic polymer is between 0.01% by weight and 1% by weight, the content of the surfactant is between 0.003% by weight and 1% by weight, and the content of the buffer is between 0.1% by weight and 5% by weight.

16. The ophthalmic liquid composition according to claim 12, characterized in that, The ophthalmic liquid composition further comprises: a functional additive, wherein the content of the functional additive is between 0.00001% by weight and 5% by weight.

17. The ophthalmic liquid composition according to claim 12, characterized in that, The hydrophilic polymer is selected from at least one of the group consisting of: sodium γ-polyglutamate, hyaluronic acid, polyethylene glycol, poly(2-methacryloyloxyethylphosphorylcholine), polyvinylpyrrolidone, polyacrylic acid, polyvinyl alcohol, and polyaspartic acid.

18. The ophthalmic liquid composition according to claim 17, characterized in that, The hydrophilic polymer comprises: sodium γ-polyglutamate and polyethylene glycol.

19. The ophthalmic liquid composition according to claim 12, characterized in that, The surfactant is selected from at least one of the group consisting of: polysorbate, polyoxypropylene glycol, polyoxyethylene glycol, sorbitan oleate, sorbitan monolaurate, sorbitan tristearate, sodium lauryl sulfate, sodium lauryl ether sulfate, alkyl sulfosuccinate, monooctyl sulfosuccinate, dioctyl sulfosuccinate, sodium dioctyl sulfosuccinate, glyceryl monostearate, and styrene-ethylene oxide copolymer.

20. The ophthalmic liquid composition according to claim 16, characterized in that, The functional additive is selected from at least one of the group consisting of xanthine and its derivatives, terpenoids, and vitamins.

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