Sample analysis apparatus

Abstract

The present application relates to a sample analysis apparatus, wherein a sample stage (10) thereof is provided with loading positions (110, 120), and the loading positions are capable of simultaneously accommodating a first sample carrier (21) and a second sample carrier (22) and / or capable of accommodating the first sample carrier (21) and the second sample carrier (22) in a time-shared manner. The first sample carrier (21) and the second sample carrier (22) have different morphological structures for accommodating samples. An imaging module (20) of the sample analysis apparatus is arranged relative to a sample stage (10), and the imaging module (20) is capable of photographing a sample in a first sample carrier (21) and / or a second sample carrier (22) located on loading positions (110, 120), so as to acquire a sample image of the sample in the first sample carrier (21) and / or a sample image of the sample in the second sample carrier (22), thereby enabling analysis of samples in sample carriers having two different morphologies.

Description

Sample analysis device Technical Field

[0001] This application relates to the field of medical devices, specifically to a sample analysis device for analyzing samples. Background Technology

[0002] Formed element analysis (morphological analysis) of samples involves microscopic examination of clinical samples such as blood, feces, urine, skin, ear secretions, tissue sections, and exfoliated cells in body fluids to observe microscopic symptoms, thereby providing a basis for clinical diagnosis of diseases in the examined subject (such as pets). Different types of formed element samples vary greatly in characteristics. Pet hospitals typically use glass slides or smears to prepare dry slides for observation, which is a cumbersome and time-consuming manual operation.

[0003] Typically, before performing morphological analysis, clinical samples such as blood and urine need to be counted or chemically analyzed, and the necessity of morphological analysis is determined based on abnormal count results. Due to the varying thickness of manually processed samples, it is difficult to accurately quantify and analyze the concentration of analytes on dried slides. Therefore, an additional counter is needed to quantify the concentration of components in liquid samples, increasing the cost and space requirements of veterinary hospitals.

[0004] With the development of human physical analysis equipment technology in recent years, integrated equipment for counting and morphology of blood, urine, and body fluid components has gradually entered the pet market. It uses a cartridge or counting cell to integrate morphological analysis and counting in liquid phase.

[0005] However, for samples such as tissue sections, skin scrapings, and blood morphology classification, the significant differences in the thickness of morphological components, observation distance, and material refraction between dry and wet slides mean that the optical devices of equipment used for wet slide counting and observation cannot directly observe dry slides. Direct observation of artificially prepared dry slides remains the mainstream testing method in pet hospitals. Application content

[0006] One of the objectives of this application is to provide a sample analysis device for detecting samples in at least two different types of sample carriers.

[0007] For the above purposes, some embodiments of this application provide a sample analysis apparatus, including:

[0008] A stage, the stage having a bearing position capable of simultaneously bearing a first sample carrier and a second sample carrier and / or capable of bearing the first sample carrier and the second sample carrier in a time-sharing manner; the first sample carrier and the second sample carrier have different shapes for bearing samples;

[0009] An imaging module is disposed relative to the stage, and the imaging module is capable of capturing images of samples in a first sample carrier and / or a second sample carrier located on the bearing position, so as to obtain sample images of the samples in the first sample carrier and / or the samples in the second sample carrier.

[0010] The system includes a control unit connected to the imaging module. The control unit is capable of analyzing the sample image and obtaining detection results for the sample in the first sample carrier and / or for the sample in the second sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

[0011] In the above sample analysis device, the stage has a support position that can simultaneously support a first sample carrier and a second sample carrier, and / or support the first sample carrier and the second sample carrier at different times. The first sample carrier and the second sample carrier have different morphological structures for supporting samples, and samples can be supported on the first sample carrier and the second sample carrier in different forms. The imaging module of the sample analysis device is positioned relative to the stage. This imaging module can capture images of the samples in the first sample carrier and / or the second sample carrier located on the support position to obtain sample images of the samples in the first sample carrier and / or the samples in the second sample carrier, thereby enabling the detection of samples in two different morphological sample carriers.

[0012] In some embodiments, the first sample carrier has a planar support structure for carrying the sample; and / or, the second sample carrier has a support structure for carrying the sample that includes at least one cavity.

[0013] In some embodiments, the first sample carrier is a plate-shaped slide, and the plane on the outer wall of the slide is used to support the sample;

[0014] And / or, the second sample carrier is a box structure, the cavity of the box structure having at least one opening and at least one flow channel for carrying the sample, the opening being in communication with the flow channel.

[0015] In some embodiments, there are at least two carrier positions, at least one of which is a first carrier position capable of carrying the first sample carrier, and at least one of which is a second carrier position capable of carrying the second sample carrier.

[0016] In some embodiments, a transfer mechanism is also included, which is used to drive the first carrier position and / or the second carrier position to move relative to the imaging module, so that the first carrier position can be moved to the imaging range of the imaging module and / or the second carrier position can be moved to the imaging range of the imaging module.

[0017] In some embodiments, the movement direction of the first bearing position and / or the second bearing position is horizontal, and the imaging module is located above or below the movement trajectory of the first bearing position and / or the second bearing position.

[0018] In some embodiments, the imaging module includes at least a first imaging module and a second imaging module. The first imaging module is configured correspondingly to the first carrier position to capture images of the sample in the first sample carrier, and the second imaging module is configured correspondingly to the second carrier position to capture images of the sample in the second sample carrier.

[0019] In some embodiments, a transfer mechanism is also included. The shared imaging module is a set of shared imaging modules. The transfer mechanism is used to drive the imaging module to move relative to the first carrier position and / or the second carrier position, so that the imaging module can move to a position opposite to the first carrier position to photograph the sample in the first sample carrier, and / or enable the imaging module to move to a position opposite to the second carrier position to photograph the sample in the second sample carrier.

[0020] In some embodiments, at least one of the carrier positions is a shared carrier position, which has a shared carrier structure capable of carrying both the first sample carrier and the second sample carrier.

[0021] In some embodiments, the imaging module is a set of shared imaging modules, which are arranged opposite to the shared carrier position. The shared imaging module can be used to capture samples in the first sample carrier located on the shared carrier position, and can also capture samples in the second sample carrier located on the shared carrier position.

[0022] In some embodiments, an illumination module is also included, which is disposed on both sides of the bearing position, and the illumination module is used to illuminate the first sample carrier and / or the second sample carrier on the bearing position to help the imaging module to capture the samples in the first sample carrier and / or the second sample carrier.

[0023] In some embodiments, a sample pretreatment module is also included, the sample pretreatment module having a pipetting assembly for pretreatment of samples in the first sample carrier and / or the second sample carrier.

[0024] In some embodiments, at least one carrier area is divided into a preprocessing area and / or a detection area. The sample carried in the preprocessing area is used for preprocessing by the corresponding preprocessing module, and the sample carried in the detection area is used for imaging by the imaging module.

[0025] In some embodiments, there are two or more bearing positions, and each bearing position is located on the same platform;

[0026] Alternatively, there may be two or more bearing positions, and the platform may be divided into multiple sub-platforms, each of which may have at least one bearing position.

[0027] In some embodiments, the samples carried by the first sample carrier include blood samples, skin samples, and / or pathological slide samples;

[0028] And / or, the samples carried by the second sample carrier include blood samples, feces, urine samples, ear canal secretion samples and / or fine needle aspiration samples.

[0029] One of the objectives of this application is to provide a sample analysis device to improve the efficiency of sample detection.

[0030] For the above purposes, some embodiments of this application provide a sample analysis apparatus, including:

[0031] A stage having a support position capable of simultaneously supporting at least two sample carriers; each sample carrier may have the same or different shapes for supporting samples.

[0032] An imaging module is provided, which is positioned relative to the stage, and is capable of capturing images of samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier.

[0033] The system includes a control unit connected to the imaging module. The control unit is capable of analyzing the sample images and obtaining detection results for the samples in each of the sample carriers. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

[0034] In the above sample analysis device, the stage has a support position that can simultaneously support at least two sample carriers, each with the same or different morphological structures for carrying the sample. The imaging module of the sample analysis device is positioned relative to the stage. This imaging module can capture images of the samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier, thereby enabling the detection of samples in at least two sample carriers and improving detection efficiency.

[0035] In some embodiments, the sample carrier is a first sample carrier, which is a slide structure, and the slide structure is a planar support structure for carrying the sample.

[0036] Alternatively, the sample carrier may be a second sample carrier, which is a box structure, and the box structure for carrying the sample includes at least one cavity.

[0037] In some embodiments, the sample carried by the first sample carrier includes at least one of skin, ear canal secretions, blood, pathological sections, body fluids, and urine;

[0038] And / or, the sample carried by the second sample carrier includes at least one of blood, ear canal secretions, urine, feces, and body fluids.

[0039] One of the objectives of this application is to provide a sample analysis device capable of detecting samples in two different forms of sample carriers.

[0040] To achieve the above objectives, some embodiments of this application provide a sample analysis apparatus, characterized in that it includes:

[0041] A stage having bearing positions for simultaneously or at different times bearing a first sample carrier and a second sample carrier; the first sample carrier and the second sample carrier have different shapes for bearing samples;

[0042] An imaging module is provided, which is positioned relative to the stage, and is capable of capturing images of samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier.

[0043] and a control unit, which is signal-connected to the imaging module;

[0044] The control unit has a first operating mode and a second operating mode;

[0045] In the first operating mode, the control unit controls the imaging module to capture images of the sample in the first sample carrier located on the bearing position, obtain sample images, and analyzes the sample images to obtain detection results about the sample in the first sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

[0046] In the second operating mode, the control unit controls the imaging module to capture images of the sample in the second sample carrier located on the bearing position, obtain sample images, and analyzes the sample images to obtain detection results about the sample in the second sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

[0047] In the above sample analysis device, the stage's support position can simultaneously support the first sample carrier and the second sample carrier, and / or can support the first sample carrier and the second sample carrier in a time-sharing manner. The first and second sample carriers have different morphological structures for supporting the samples, and the samples can be supported on the first and second sample carriers in different forms. The control unit has a first operating mode for detecting samples in the first sample carrier and a second operating mode for detecting samples in the second sample carrier, thereby enabling the detection of samples from two different morphological sample carriers.

[0048] In some embodiments, in the first operating mode, the control unit calls the corresponding first algorithm unit to analyze the sample image and obtain the detection result of the sample in the first sample carrier;

[0049] And / or, in the second operating mode, the control unit calls the corresponding second algorithm unit to analyze the sample image and obtain the detection result of the sample in the second sample carrier.

[0050] In some embodiments, an operating mode selection module is also included, which is signal-connected to the control unit, and the operating mode selection module allows the user to select to operate the first operating mode and / or the second operating mode.

[0051] In some embodiments, the operating mode selection module includes a human-computer interaction module, which has a display component for displaying relevant information about the first operating mode and the second operating mode for the user to select.

[0052] In some embodiments, the information related to the first operating mode and the information related to the second operating mode displayed by the display component both include the mode name, the type of sample being detected, and at least one of the detection items.

[0053] In some embodiments, the first sample carrier is a slide structure, and the slide structure is a planar support structure for carrying the sample;

[0054] And / or, the second sample carrier is a box structure, the box structure for carrying the sample includes at least one cavity.

[0055] In some embodiments, the control unit determines the operating mode according to the following rules:

[0056] The mapping relationship between the preset sample types and / or detection items in the device and the first operating mode and the second operating mode;

[0057] The system receives user input instructions, which include sample type and / or detection items. Based on the correspondence between the sample type and / or detection items indicated by the instructions in the mapping relationship, it determines whether to run the first running mode or the second running mode.

[0058] In some embodiments, the sample types to which the first operating mode applies include blood, skin, and / or pathological sections;

[0059] And / or, the sample types applicable to the second operating mode include blood, feces, urine, ear canal secretions, and / or fine needle aspiration.

[0060] In some embodiments, the detection parameters of the samples to which the first operating mode is applicable include blood sample detection parameters, skin sample detection parameters and / or pathological section sample detection parameters. The blood sample detection parameters include anemia classification and / or blood parasites. The skin sample detection parameters include mites, lice, fleas, ticks, protozoa, bacteria and / or fungi or spores. The pathological section sample detection parameters include tumors, mitotic figures and / or tissue and cell damage.

[0061] And / or, the detection parameters applicable to the samples in the second operating mode include blood sample detection parameters, fecal sample detection parameters, urine sample detection parameters, ear canal secretion sample detection parameters, and / or fine needle aspiration sample detection parameters; the blood sample detection parameters include red blood cell count, shadow red blood cells, nucleated red blood cells, abnormal red blood cells, reticulocytes, white blood cell count and differential, platelet count and differential, and / or platelet aggregation; the fecal detection parameters include parasites, digestive products, bacteria and fungi, cells, and / or plant fibers; the urine sample detection parameters include cells, casts, crystals, and / or bacteria and fungi; the ear canal secretion sample detection parameters include bacteria and fungi and / or ear mites; and the fine needle aspiration sample detection parameters include normal cells, tumor cells, and / or microorganisms. Attached Figure Description

[0062] Figure 1 is a schematic diagram of the modules of the sample analysis device in one embodiment of this application;

[0063] Figure 2 is a schematic diagram of the modules of the sample analysis device in another embodiment of this application;

[0064] Figure 3 is a schematic diagram of the first sample carrier in one embodiment of this application;

[0065] Figure 4 is a schematic diagram of the second sample carrier in one embodiment of this application;

[0066] Figure 5 is an exploded schematic diagram of the second sample carrier in another embodiment of this application;

[0067] Figure 6 is a schematic diagram of the partitioning of the second sample carrier in one embodiment of this application;

[0068] Figure 7 is a schematic diagram of the imaging module and illumination module and the sample carrier in one embodiment of this application;

[0069] Figure 8 is a schematic diagram of the second sample carrier being photographed in one embodiment of this application;

[0070] Figure 9 is a schematic diagram of the positioning focus point on the second sample carrier in one embodiment of this application;

[0071] Figure 10 is a schematic diagram of the detection process of the first sample carrier in one embodiment of this application;

[0072] Figure 11 is a schematic diagram of the detection process of the second sample carrier in one embodiment of this application;

[0073] Figure 12 is a schematic diagram of the mapping relationship between detection items and the first and second operating modes in one embodiment of this application. Detailed Implementation

[0074] The present application will now be described in further detail with reference to the accompanying drawings and specific embodiments. Similar elements in different embodiments are referred to by related similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0075] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0076] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the objects being described and have no sequential or technical meaning. Unless otherwise specified, the terms "connection" and "linkage" used in this application include both direct and indirect connections (linkages).

[0077] In order to enable the sample analysis device to be applied to samples in at least two different types of sample carriers, some embodiments of this application provide a sample analysis device that can be applied to the detection and analysis of human and / or animal samples.

[0078] Please refer to Figures 1 and 2. In some embodiments, the sample analysis device 1 includes a stage 10, an imaging module 20, and a control unit 30, etc.

[0079] The stage 10 is used to support a sample carrier containing a sample, and it can have any structure capable of supporting the sample carrier, such as a platform-like structure, a support-like structure, etc. Specifically, the stage 10 has at least one support position (such as 110, 120). When there are two or more support positions, each support position can be located on the same stage 10. Alternatively, the stage 10 can also be composed of two or more sub-stages 10, and when there are two or more support positions, each sub-stage 10 is provided with at least one support position.

[0080] The bearing position can simultaneously bear the first sample carrier 21 and the second sample carrier 22 and / or can bear the first sample carrier 21 and the second sample carrier 22 at different times. The first sample carrier 21 and the second sample carrier 22 can be collectively referred to as the sample carrier, which is used to bear and preserve the sample. After the sample carrier is loaded onto the stage 10, the sample analysis device 1 can perform relevant tests on the sample in the sample carrier. Wherein, the bearing position simultaneously bearing the first sample carrier 21 and the second sample carrier 22 means that the shape, size, structure, or combination thereof of the bearing position can meet the requirement of simultaneously bearing the first sample carrier 21 and the second sample carrier 22. The bearing position at different times bearing the first sample carrier 21 and the second sample carrier 22 means that the bearing position can bear the first sample carrier 21 and the second sample carrier 22 at different times, that is, the shape, size, structure, or combination thereof of the bearing position can meet the bearing requirements of bearing the first sample carrier 21 alone, and can also meet the bearing requirements of bearing the second sample carrier 22 alone. The aforementioned support can be either a simple placement of the first sample carrier 21 and the second sample carrier 22 on the support position, or the support position can have a fixing or limiting structure to fix or limit the first sample carrier 21 and the second sample carrier 22 on the support position. That is, the support position can be either a simple plane on the stage 10 for placing the sample carrier, or a support structure on the stage 10 that can limit or fix the sample carrier.

[0081] The first sample carrier 21 and the second sample carrier 22 have different forms for carrying the sample; that is, the first sample carrier 21 and the second sample carrier 22 are two different types of sample carriers with different structural forms for carrying the sample. For example, in some embodiments, the first sample carrier 21 can be, but is not limited to, a slide structure. The slide structure is a planar surface rather than a cavity. More specifically, referring to Figure 3, in some embodiments, the slide structure can be a slide (e.g., a glass slide, a highly transparent plastic sheet, or a slide of other materials), and the planar surface 211 on the outer wall of the slide is used to carry the sample 3. As another example, in some embodiments, the second sample carrier 22 is a box structure, distinct from the planar surface of the slide structure. The box structure includes at least one cavity for carrying the sample, and the sample can flow within the cavity if necessary. More specifically, referring to Figure 4, in some embodiments, the second sample carrier 22 is a box structure with at least one opening 221 and at least one flow channel 222 for carrying the sample (the dashed box in the figure represents the flow channel 222 located inside). The flow channel 222 can be, but is not limited to, a cavity, a groove, a channel hole, etc. For example, in some embodiments, the flow channel 222 can also be partially exposed to form a semi-groove. The opening 221 communicates with the flow channel 222, and the sample can be added into the flow channel 222 through the opening 221 or removed from the flow channel 222. Of course, in other embodiments, the first sample carrier 21 can also be a box structure, and the second sample carrier 22 can also be a slide structure. The first sample carrier 21 and the second sample carrier 22 will be described in more detail later.

[0082] Because the first sample carrier 21 and the second sample carrier 22 are used to carry samples in different forms, the types of samples they carry may also be different. For example, in some embodiments, the sample carried by the first sample carrier 21 includes at least one of skin, ear canal secretions, blood, pathological sections, tissue cells, body fluids, and urine; and / or, the sample carried by the second sample carrier 22 includes at least one of blood, ear canal secretions, urine, tissue fluid, feces, and body fluids.

[0083] The imaging module 20 is used to capture images of samples for analysis. The imaging module 20 can be, but is not limited to, existing microscope imaging modules. Referring to Figures 1 and 2, in some embodiments, the imaging module 20 is positioned relative to the stage 10. This relative positioning refers to functional relative positioning. The imaging module 20 can capture images of samples in the first sample carrier 21 and / or the second sample carrier 22 located on the support position to obtain sample images of the samples in the first sample carrier 21 and / or the second sample carrier 22. The imaging module 20 can be positioned above or below the support position to enable quick and direct image capture of the samples on the support position. Of course, the imaging module 20 can also be positioned relative to the support position at any location, such as on the side of the stage 10, and can be moved to a position where it can capture images of the samples on the support position.

[0084] The control unit 30 is the control module of the sample analysis device 1, and it is signal-connected to the imaging module 20. The control unit 30 can analyze sample images of the samples in the first sample carrier 21 and / or the samples in the second sample carrier 22, and obtain detection results for the samples in the first sample carrier 21 and / or the samples in the second sample carrier 22. These detection results include at least one of particle counting, particle morphology characterization (morphological analysis), and particle classification. These results can help doctors or relevant personnel better diagnose and treat the examined subjects.

[0085] In the above sample analysis device 1, the stage 10 can simultaneously support the first sample carrier 21 and the second sample carrier 22 and / or support the first sample carrier 21 and the second sample carrier 22 in a time-sharing manner. The imaging module 20 can capture images of the samples in the first sample carrier 21 and / or the second sample carrier 22 located on the support position to obtain sample images of the samples in the first sample carrier 21 and / or the samples in the second sample carrier 22, thereby enabling the detection of samples in two different forms of sample carriers.

[0086] Referring to Figures 1 and 2, in some embodiments, to simultaneously support the first sample carrier 21 and the second sample carrier 22, there are at least two support positions. At least one support position is a first support position 110 capable of supporting the first sample carrier 21, and at least one support position is a second support position 120 capable of supporting the second sample carrier 22. The shape, size, structure, or combination thereof of the first support position 110 satisfies the requirements for supporting the first sample carrier 21 alone, and the shape, size, structure, or combination thereof of the second support position 120 satisfies the requirements for supporting the second sample carrier 22 alone. In this embodiment, the first support position 110 and the second support position 120 can also be used to support the first sample carrier 21 and the second sample carrier 22 in a time-sharing manner.

[0087] In other embodiments, in order to support the first sample carrier 21 and the second sample carrier 22 at different times, at least one support position is a shared support position. This shared support position has a shared support structure capable of supporting both the first sample carrier 21 and the second sample carrier 22. The shape, size, structure, or combination thereof of this shared support structure can satisfy the support requirements for supporting both the first sample carrier 21 and the second sample carrier 22 individually. In this embodiment, the number of support positions can be reduced to a minimum of one (i.e., a shared support position), which optimizes the structure of the stage 10 and reduces its volume.

[0088] Furthermore, in some embodiments, when the imaging module 20 is capturing images of a sample, the imaging module 20 is moved between at least two carrier positions by moving the imaging module 20 and / or the carrier position, so as to capture images of the samples on at least two carrier positions, and / or, at least one carrier position can be moved into the capturing range of at least two imaging modules 20 for capturing images.

[0089] Specifically, in some embodiments, a transfer mechanism 40 is also included. The transfer mechanism 40 is used to drive the first support position 110 and / or the second support position 120 to move relative to the imaging module 20, so that the first support position 110 can move into the imaging range of the imaging module 20 and / or the second support position 120 can move into the imaging range of the imaging module 20.

[0090] Further referring to Figures 1 and 2, in this embodiment, the transfer mechanism 40 is connected to the stage 10 to drive the stage 10 to move, so that the first support position 110 or the second support position 120 moves within the imaging range of at least two imaging modules 20 for imaging. Alternatively, the transfer mechanism 40 may not drive the entire stage 10 to move, but instead drive the first support position 110 and the second support position 120 separately to move within the imaging range of at least one imaging module 20 for imaging.

[0091] Furthermore, referring to Figures 1 and 2, in some embodiments, the movement direction of the first support position 110 and / or the second support position 120 is horizontal. In this case, the imaging module 20 is positioned above or below the movement trajectory of the first support position 110 and / or the second support position 120. In the embodiment shown in Figure 1, the imaging module 20 is located above the movement trajectory of the first support position 110 and the second support position 120. In the embodiment shown in Figure 2, the imaging module 20 is located below the movement trajectory of the first support position 110 and the second support position 120.

[0092] Of course, in other embodiments, the movement direction of the first bearing position 110 and / or the second bearing position 120 may also be other directions, such as moving along the vertical direction or other directions.

[0093] In other embodiments, the shared imaging module may be a single set of shared imaging modules. The transfer mechanism 40 is used to drive the shared imaging module to move relative to the first support position 110 and / or the second support position 120, so that the shared imaging module can move to a position opposite to the first support position 110 to photograph the sample in the first sample carrier 21, and / or move to a position opposite to the second support position 120 to photograph the sample in the second sample carrier 22. When there are more sample carriers on the support position, the shared imaging module can also cover more sample carriers.

[0094] In the above embodiments, the transfer mechanism 40 can be moved by any existing feasible moving structure, such as being driven by a motor and moving the imaging module 20 and / or the carrier position through existing transmission mechanisms such as gear transmission groups and synchronous belt pulley transmission mechanisms.

[0095] In contrast, in other embodiments, the imaging module 20 may also maintain a fixed position relative to the corresponding carrier position to capture the sample on the corresponding carrier position. In this case, the imaging module 20 and the carrier position can maintain a fixed relative position, and the imaging range of one imaging module 20 covers one or more carrier positions. When there are two or more carrier positions, there may also be two or more imaging modules 20, with each imaging module 20 performing fixed imaging for one or more carrier positions.

[0096] Under this approach, in some embodiments, the imaging module 20 is a shared imaging module, and the carrier position can be a shared carrier position. The shared imaging module is positioned opposite to the shared carrier position, and can be used to image samples in the first sample carrier 21 located on the shared carrier position, as well as samples in the second sample carrier 22 located on the shared carrier position. Of course, the shared carrier position can also be replaced by the first carrier position 110, the second carrier position 120, and more carrier positions (if required). By covering multiple carrier positions with the imaging range of one shared imaging module, coverage of two or more carrier positions can be achieved without moving the imaging module 20.

[0097] Furthermore, the specific imaging process in some embodiments will now be described. To better describe the imaging process, some examples of the first sample carrier 21 and the second sample carrier 22 will be described in more detail first.

[0098] Referring to Figure 3, in some embodiments, the first sample carrier 21 is a slide. This slide can be a commercially available standard glass slide, or it can be a custom-designed, injection-molded high-transmittance plastic sheet. Sample pretreatment is performed manually or by machine to prepare the slide, which can then be placed in the sample analysis device 1 for morphological analysis. In some embodiments, the sample on the slide may be dried (this type of slide is referred to in the art as a dry slide). Of course, in other embodiments, the sample on the slide may not be dried, but rather retained in its liquid form for detection (this type of slide can be considered a wet slide).

[0099] The second sample carrier 22 is a box-shaped structure, typically used to hold liquid samples (this type of box-shaped sample carrier is referred to in the art as a box-type wet slide). This box-shaped structure can have a wide variety of structures and designs, and can directly utilize various existing publicly disclosed box-type wet slides. For example, in some embodiments, the second sample carrier 22 may have a customized counting cell or a liquid sample loading mechanism such as a chip containing a flow channel structure, with an internal area suitable for direct microscopic examination. Alternatively, in some embodiments, the second sample carrier 22 may also be a cartridge-type structure containing multiple reagent chambers, wherein the cartridge-type structure also includes a liquid sample processing chamber and a detection chamber for morphological analysis and counting (a cavity area suitable for direct microscopic observation).

[0100] Furthermore, this application only provides illustrative examples of the structure of some cassette-type wet films, but the second sample carrier 22 is not limited to the embodiments shown in this embodiment.

[0101] Referring to Figure 5, in some embodiments, the second sample carrier 22 includes at least an upper cover 223 and a bottom plate 224. The upper cover 223 and the bottom plate 224 are made of a high-transmittance material, which may be, but is not limited to, PMMA, PC, COC, quartz, or glass. The materials of the upper cover 223 and the bottom plate 224 may be the same or different, but both contain a microscopic examination area for the imaging module 20 to capture images of the sample. The upper cover 223 and the bottom plate 224 are directly encapsulated by methods such as hot pressing, anodic bonding, adhesive bonding, UV curing, ultrasonic welding, or laser welding. A detection chamber is formed on the bottom plate 224 or the upper cover 223, capable of containing liquid samples. In the embodiment shown in Figure 4, the bottom plate 224 has a detection chamber 225, but the upper cover 223 does not. This detection chamber 225 is part of the aforementioned flow channel 222.

[0102] Of course, in some embodiments, the upper cover 223 and the bottom plate 224 may not have a detection chamber 225 structure. Instead, the upper cover 223 and the bottom plate 224 are separated by an intermediate layer 226, and a flow channel 222 for accommodating liquid samples is formed by a slot 227 on the intermediate layer 226. The intermediate layer 226 can connect the upper cover 223 and the bottom plate 224 by means of hot pressing, anodic bonding, adhesive bonding, UV curing, ultrasonic welding, laser welding, etc., to form a closed chamber that can be used for counting and morphological detection. It is worth noting that the materials of the intermediate layer 226, the upper cover 223, and the bottom plate 224 can be the same or different. For example, the intermediate layer 226 can be a non-transparent material or a multilayer composite material with double-sided or single-sided adhesive.

[0103] Of course, the second sample carrier 22 can have various shapes. Furthermore, the second sample carrier 22 can also include one or more detection chambers 225 (these detection chambers 225 are all part of the flow channel 222, i.e., in this application, these interconnected spaces are collectively referred to as the flow channel 222). The shape of the detection chamber 225 can also be rectangular or other irregular structures, and can also be customized according to the specific type of sample. The depth range of the detection chamber 225 can be a combination of one or more depth parameters, such as 0.01 mm to 2 mm.

[0104] In a more specific embodiment, the thickness of the cover plate and the base plate 224 can range from 0.01 mm to 2 mm, preferably from 0.5 mm to 1 mm, in order to minimize the loss of optical information due to thickness. The cover plate and the base plate 224 can have the same thickness, or they can be a combination of different parameters within the thickness range, depending on the observation method of the imaging module 20.

[0105] Referring to Figure 6, in some embodiments, the second sample carrier 22 can be a cartridge containing multiple reagent processing slots. The second sample carrier 22 may include a sample pretreatment area 228 for pretreatment of blood, feces, urine, tissue fluid, etc. Depending on the sample and the testing item, the sample pretreatment area 228 may have different structures. For example, in some embodiments, the sample pretreatment area 228 may include, but is not limited to, at least one of: a sample storage area 2281, a dilution area 2282, a mixing area 2283, a waste collection area 2284, a staining area 2285, and a washing area 2286. For blood samples, it may also include a lysis area. The combination of these different functional areas allows for adaptation to different sample types.

[0106] Referring to Figure 6, in some embodiments, the second sample carrier 22 may further include a morphology counting region 229. This morphology counting region 229 may include, but is not limited to, one or more detection chambers 225. The detection chambers 225 can be designed as shown in Figure 5, or other existing structures. The detection chambers 225 may be located inside the cartridge of the second sample carrier 22, integrally injection molded with the pretreatment functional area, for example, on the same second sample carrier 22. Alternatively, the morphology counting region 229 may be relatively independent of the sample pretreatment area 228, directly used for microscopic examination; that is, the sample pretreatment area 228 and the morphology counting region 229 are placed separately, for example, on two separate second sample carriers 22. Furthermore, the detection chambers 225 may also be an independent area connected to the sample pretreatment area 228 by means of hot pressing, anodic bonding, adhesive bonding, UV curing, ultrasonic welding, laser welding, etc., for example, on two interconnected second sample carriers 22.

[0107] Here, we will briefly explain the functions of each functional area.

[0108] The sample storage area 2281 is used to store specific types of samples, and can be designed in different shapes or sizes for blood, feces, urine, and tissue fluid. The dilution area 2282 contains diluents to dilute specific types of samples at different ratios, and can be designed with different dilution ratios for blood, feces, urine, and tissue fluid. The mixing area 2283 is used to mix samples with staining reagents, or samples with lysis buffer. The lysis area contains reagents capable of lysing red blood cells. The waste collection area 2284 contains a chamber for collecting waste fluid. The staining area 2285 contains different reagents for staining samples. The cleaning area 2286 contains reagents for cleaning the sample dispensing needle or tip.

[0109] Of course, the above is only a partial illustration of the first sample carrier 21 and the second sample carrier 22, but the first sample carrier 21 and the second sample carrier 22 are not limited to the structure and shape shown in the above embodiments.

[0110] For the first sample carrier 21 and the second sample carrier 22 mentioned above or in other existing systems, the imaging module 20 can directly capture images to obtain sample images of the corresponding samples. In other embodiments, the sample analysis device 1 may also include an illumination module to provide a light source for capturing images, thereby improving the capturing effect of the imaging module 20.

[0111] Referring to Figures 1, 2, and 7, in some embodiments, the illumination module 50 and the imaging module 20 are respectively located on opposite sides of the support position. The illumination module 50 is used to illuminate the first sample carrier 21 and / or the second sample carrier 22 on the support position, so as to help the imaging module 20 capture images of the samples in the first sample carrier 21 and / or the second sample carrier 22. Typically, the illumination module 50 and the imaging module 20 are located on the upper and lower sides of the support position, respectively; either the imaging module 20 can be on top, or the illumination module 50 can be on top. Of course, in some special structures, if the detection requirements are met, the illumination module 50 and the imaging module 20 can also be located on the left and right sides of the support position, etc.

[0112] Referring to Figure 7, in some embodiments, the lighting module 50 can be a Kohler lighting system comprising an LED light source 51, a light-collecting mirror 52, a light-diffusing plate 53, and a condenser lens 54. This Kohler lighting system contains incident light from multiple angles, which is more advantageous for imaging small objects. Of course, this Kohler lighting system can also be replaced with other lighting systems, such as a common parallel light source. The light-collecting mirror and the light-diffusing plate can be integrated or separate designs.

[0113] Referring to Figure 7, in some embodiments, the imaging module 20 may comprise an infinity optical system consisting of an objective lens 201, a telescope 202, and a camera 203 (such as a CMOS camera). The optical path of the imaging module 20 is perpendicular to the plane where the sample is located on the carrier, for example, perpendicular to the plane carrying the sample in the first sample carrier 21 and the detection chamber 225 of the second sample carrier 22, to complete the imaging. Of course, in some embodiments, the telescope may be a telescope containing a lens group, or it may be an adapter without a lens group; that is, the imaging module 20 may also be a finite element optical system consisting of an objective lens, an adapter, and a CMOS camera.

[0114] Referring to Figures 1 and 2, the optical path of the imaging module 20 and the optical path of the illumination module 50 are kept coaxial along the optical axis A2. This allows the illumination beam to be focused and pass through the sample in the detection chamber 225 of the second sample carrier 22, then collected and collimated by the objective lens to achieve imaging on the camera. Simultaneously, by moving the optical imaging module composed of the forming module and the illumination module 50, or by moving the stage 10 or the first sample carrier 21 and the second sample carrier 22 on the stage 10, the optical path of the imaging module 20 and the optical path of the illumination module 50 can also be kept coaxial along the optical axis A1. This allows the illumination beam to be focused and pass through the sample on the plane of the first sample carrier 21, then collected and collimated by the objective lens 201 to achieve imaging on the camera 203.

[0115] Specifically, referring to Figures 1 and 2, in some embodiments, the transfer mechanism 40 is connected to the first carrier position 110 and the second carrier position 120 to drive the first carrier position 110 and the second carrier position 120 to move horizontally left and right, so that the optical imaging module composed of the imaging module 20 and the illumination module 50 shown in Figures 1 and 2 can act on both the first sample carrier 21 and the second sample carrier 22. In this embodiment, image acquisition for both the first sample carrier 21 and the second sample carrier 22 can be achieved through a single optical module, reducing the instrument design and manufacturing costs.

[0116] Furthermore, when an optical imaging module is composed of multiple imaging modules 20 and illumination modules 50, one set of optical imaging modules can form an optical path structure relative to the first sample carrier 21 as shown in Figure A1, and another set of optical imaging modules can form an optical path structure relative to the second sample carrier 22 as shown in Figure A2. In this structure, the optical imaging modules and the bearing positions used to carry the first sample carrier 21 and the second sample carrier 22 can maintain a fixed position.

[0117] Further, referring to Figures 1 and 2, in some embodiments, the second sample carrier 22 corresponding to the second carrier position 120 has a sample pretreatment area 228 and a morphology counting area 229 (the sample pretreatment area 228 and the morphology counting area 229 can be integrated on one second sample carrier 22 or can be disposed on two second sample carriers 22). In this case, at least one carrier position of the second sample carrier 22 is divided into a pretreatment area 121 and a detection area 122. The sample carried in the pretreatment area 121 is used for pretreatment by the corresponding pretreatment module 60, and the sample carried in the detection area 122 is used for imaging by the imaging module 20. The sample pretreatment module 60 is used to process the sample before detection, and these processing procedures and operations can refer to the prior art. For example, in some embodiments, the sample pretreatment module 60 has a pipetting assembly, which is used to preprocess the samples in the first sample carrier 21 and / or the second sample carrier 22.

[0118] In some more specific embodiments, the pipetting assembly may include a vacuum pump connected to the second carrier 120 via a liquid conduit to control the flow of liquid to the sample in the second sample carrier 22 on the second carrier 120. Alternatively, the pipetting assembly may be a plunger pump containing a sampling needle, which moves up and down to aspirate liquid samples, realizing various processing steps in the sample pretreatment process. The sampling needle of the pipetting assembly may be a disposable tip to reduce cross-contamination caused by residues of different reagents and samples on the needle. Furthermore, during pretreatment, the sample pretreatment module 60 may also cooperate with the transfer mechanism 40 to achieve relative movement between the pipetting assembly and the various functional areas in the sample pretreatment area 228, automating and standardizing different sample pretreatment processes, thereby ensuring counting consistency.

[0119] The morphological counting area 229 is used by the imaging module 20 to take pictures of the sample in the detection chamber 225 of the second sample carrier 22 to achieve morphological detection and counting.

[0120] Of course, in other embodiments, when the second sample carrier 22 has only a sample preprocessing area 228 or a morphology counting area 229, at least one bearing position of the second sample carrier 22 may also have only a preprocessing area 121 or a detection area 122 for related detection and operation.

[0121] Furthermore, to achieve the counting and morphological characterization of samples in the second sample carrier 22, referring to Figure 8, in some embodiments, the focusing point 2211 of the imaging area 2210 of the detection chamber 225 of the second sample carrier 22 can be aligned with the optical axis A2 of the imaging module 20 or the optical imaging module by fixing its position or moving the imaging module 20 or the second carrier position 120, thereby achieving clear focusing. The focusing point can be single or multiple, such as 2211a, 2211b, and 2211c, to predict the focal length change of the entire imaging area. Subsequently, the transfer mechanism 40 moves the second sample carrier 22 to the initial imaging position 1601, and adjusts the focus depth and takes pictures of different imaging areas of the imaging area 2210 according to the predicted focus depth. The imaging areas are not limited to 1601, 1602, 1603, 1604, 1605, 1606, and 1607. The imaging areas 1601, 1602, 1603, 1604, 1605, 1606, and 1607 can include overlapping areas, or be adjacent or separated by a distance, depending on the sample type and statistical differences. For example, the detection of parasites in fecal samples requires scanning the entire imaging area 2210.

[0122] The first sample carrier 21 and the second sample carrier 22 can be loaded independently, and the detection order and sample type of the first sample carrier 21 and the second sample carrier 22 can be set in the program.

[0123] Furthermore, referring to Figure 10, some embodiments of this application also illustrate a detection process for the first sample carrier 21:

[0124] The first sample carrier 21 is loaded onto the corresponding carrier position, such as the first carrier position 110. The first sample carrier 21 can be prepared manually or pre-processed by a machine;

[0125] The imaging module 20 is used to capture sample images of the sample in the first sample carrier 21, for example, to focus and acquire images of the detection chamber 225;

[0126] Perform morphological analysis on the sample images and output the detection results.

[0127] Please refer to Figure 11. In some embodiments of this application, a detection process for the second sample carrier 22 is also shown:

[0128] The second sample carrier 22 is loaded onto the corresponding carrier position, such as the second carrier position 120. This second sample carrier 22 can be prepared manually or pre-processed by a machine.

[0129] Samples are preprocessed. For example, the samples in the second sample carrier 22 are standardized using the preprocessing module 60.

[0130] The processed sample is loaded into the detection chamber. For example, the sample after standard pretreatment is taken out through a sampling needle and added into the detection chamber 225 of the second sample carrier 22;

[0131] The imaging module 20 locates and focuses the sample. For example, it locates and focuses the imaging area 2210 of the second sample carrier 22.

[0132] To capture images. For example, the device acquires images of imaging area 2210 according to a predetermined path;

[0133] The sample images are subjected to morphological analysis and counting. For example, the control unit 30 analyzes the acquired sample images and finally outputs the morphological analysis results and counting results.

[0134] Of course, the above is only a schematic diagram of a detection process for the first sample carrier 21 and the second sample carrier 22. In other embodiments, different detection processes can be used to complete the detection of samples in the first sample carrier 21 and the second sample carrier 22.

[0135] Furthermore, please refer again to Figures 1 and 2. In the entire device, the modules can be directly or indirectly connected and fixed to each other through corresponding support connection structures. For example, the stage 10 can be used as a support contact, and other modules can be directly or indirectly installed on the stage 10.

[0136] On the other hand, some embodiments of this application also provide a sample analysis device 1, which includes a stage 10, an imaging module 20, and a control unit 30. The stage 10 has a bearing position for simultaneously or sequentially bearing a first sample carrier 21 and a second sample carrier 22; the first sample carrier 21 and the second sample carrier 22 have different shapes for bearing samples. The imaging module 20 is disposed relative to the stage 10, and the imaging module 20 can capture images of the samples in the sample carriers located on the bearing positions to obtain sample images of the samples in each sample carrier. The sample analysis device 1 can be the sample analysis device 1 shown in the foregoing embodiments, or other sample analysis devices 1 with similar structures can also be used.

[0137] In this embodiment, the control unit 30 of the sample analysis device 1 has a first operating mode and a second operating mode.

[0138] In the first operating mode, the control unit 30 controls the imaging module 20 to take pictures of the sample in the first sample carrier 21 located on the carrier position, obtain the sample image, and analyze the sample image to obtain the detection results of the sample in the first sample carrier 21. The detection results include at least one of particle count, particle morphology characterization and particle classification.

[0139] In the second operating mode, the control unit 30 controls the imaging module 20 to take pictures of the sample in the second sample carrier 22 located on the carrier position, obtain sample images, and analyze the sample images to obtain detection results about the sample in the second sample carrier 22. The detection results include at least one of particle count, particle morphology characterization and particle classification.

[0140] In the above sample analysis device 1, the control unit 30 has a first operating mode for detecting samples in the first sample carrier 21 and a second operating mode for detecting samples in the second sample carrier 22, thereby realizing the detection of samples in two different forms of sample carriers.

[0141] In some embodiments, the samples used in the first operating mode include at least one of skin, ear canal secretions, blood, pathological sections, body fluids, and urine;

[0142] And / or, the samples used in the second operating mode include at least one of blood, ear canal secretions, urine, feces, and body fluids.

[0143] In some embodiments, in the first operating mode, the control unit 30 calls the corresponding first algorithm unit to analyze the sample image and obtain the detection result of the sample in the first sample carrier 21; the first algorithm unit may refer to the algorithm in the prior art for the first sample carrier 21 (such as for the slide).

[0144] And / or, in the second operating mode, the control unit 30 invokes the corresponding second algorithm unit to analyze the sample image and obtain the detection results regarding the sample in the second sample carrier 22. This second algorithm unit may refer to existing algorithms for the second sample carrier 22 (such as those for existing cartridge-type wet films).

[0145] In some embodiments, an operating mode selection module is also included. The operating mode selection module is signal-connected to the control unit 30, and allows the user to select between a first operating mode and / or a second operating mode. This operating mode selection module can be any structure capable of receiving user input, such as, but not limited to, physical buttons, touch buttons, a display screen, a motion capture unit, a voice input unit, or a wireless communication unit.

[0146] For example, in some embodiments, the operating mode selection module includes a human-computer interaction module, which can adopt any existing method and structure that enables human-computer interaction. For example, in some embodiments, the human-computer interaction module has a display component for displaying relevant information about the first operating mode and the second operating mode for the user to select.

[0147] In some embodiments, a user-selectable mode is shown, in which the information displayed by the display component for both the first and second operating modes includes a mode name, sample type, and at least one of the detection items. The control unit 30 can automatically activate either the first or second operating mode based on the user's selection.

[0148] Some embodiments illustrate the rules by which the control unit 30 determines the operating mode:

[0149] The mapping relationship between the preset sample types and / or detection items in the device and the first and second operating modes;

[0150] The system receives user input instructions, which include sample type and / or detection items. Based on the correspondence between the sample type and / or detection items indicated by the instructions in the mapping relationship, it determines whether to run a first operating mode or a second operating mode.

[0151] Referring to Figure 12, in some embodiments, the mapping relationship can be described as follows:

[0152] When the user inputs a command that includes any one of the detection items, namely blood morphology, skin sampling, and pathological section, the control unit 30 starts the first operating mode;

[0153] When the user inputs a command that includes any one of the following tests: blood CBC count, stool routine test, urine routine test, ear canal secretions, and body fluids, the control unit 30 activates the second operating mode.

[0154] In some embodiments, the mapping relationship may also be described as follows:

[0155] The first operating mode is applicable to sample types including blood, skin, and pathological sections. When the user inputs a command containing either skin or pathological section as the sample type, the control unit 30 activates the first operating mode.

[0156] And / or, the sample types applicable to the second operating mode include blood, feces, urine, ear canal secretions, and / or fine needle aspiration. When the user inputs a command containing a sample type of skin or pathological section, the control unit 30 activates the second operating mode.

[0157] When the user inputs instructions that include the sample type as blood, the user can select either the first operating mode or the second operating mode based on the user's instructions, the specific detection parameters of the sample, or preset rules.

[0158] In some embodiments, the mapping relationship may also be as follows:

[0159] The detection parameters applicable to the first operating mode include blood sample detection parameters, skin sample detection parameters, and / or pathological section sample detection parameters. The blood sample detection parameters include anemia classification and / or blood parasites. The skin sample detection parameters include mites, lice, fleas, ticks, protozoa, bacteria, and / or fungi or spores. The pathological section sample detection parameters include tumors, mitotic figures, and / or tissue and cell damage. When the user inputs a command that includes the detection of detection parameters for any of the above samples, the control unit 30 activates the first operating mode.

[0160] And / or, the detection parameters applicable to the samples in the second operating mode include blood sample detection parameters, fecal sample detection parameters, urine sample detection parameters, ear canal secretion sample detection parameters, and / or fine needle aspiration sample detection parameters; the blood sample detection parameters include red blood cell count, shadow red blood cells, nucleated red blood cells, abnormal red blood cells, reticulocytes, white blood cell count and differential, platelet count and differential, and / or platelet aggregation; the fecal detection parameters include parasites, digestive products, bacteria and fungi, cells, and / or plant fibers; the urine sample detection parameters include cells, casts, crystals, and / or bacteria and fungi; the ear canal secretion sample detection parameters include bacteria and fungi and / or ear mites; and the fine needle aspiration sample detection parameters include normal cells, tumor cells, and / or microorganisms. When the user inputs a command that includes the detection of any of the above sample detection parameters, the control unit 30 activates the second operating mode.

[0161] Of course, the above mapping relationships are just some examples. In other embodiments, the mapping relationships can be adjusted or detection items can be added or removed according to actual needs.

[0162] On the other hand, in addition to the sample carriers of different forms shown in the foregoing embodiments, some embodiments of this application provide another sample analysis device 1 to improve the sample detection efficiency.

[0163] The sample analysis device 1 includes a stage 10, an imaging module 20, and a control unit 30. The stage 10 has a bearing position capable of simultaneously bearing at least two sample carriers; each sample carrier may have the same or different shapes for bearing the sample. The sample carrier may include both the aforementioned first sample carrier 21 and second sample carrier 22, or it may consist only of the first sample carrier 21, the second sample carrier 22, or other types of sample carriers.

[0164] The imaging module 20 is positioned relative to the stage 10. The imaging module 20 can capture images of samples in the sample carriers located on the support positions to obtain sample images of the samples in each sample carrier. The control unit 30 is signal-connected to the imaging module 20. The control unit 30 can analyze the sample images and obtain detection results for the samples in each sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification. Except for the different sample carriers, the stage 10, imaging module 20, and control unit 30 can adopt the structures shown in the aforementioned embodiments.

[0165] In the sample analysis device 1 described above, the support position can simultaneously support at least two sample carriers, each of which may have the same or different morphological structures for supporting the sample. The imaging module 20 of the sample analysis device 1 is positioned relative to the stage 10. The imaging module 20 can capture images of the samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier, thereby enabling the detection of samples in at least two sample carriers and improving detection efficiency.

[0166] The above examples illustrate this application only to aid understanding and are not intended to limit its scope. Those skilled in the art to which this application pertains can make various simple deductions, modifications, or substitutions based on the ideas presented.

Claims

1. A sample analysis device, characterized by, include: A stage, wherein the stage has a bearing position capable of simultaneously bearing a first sample carrier and a second sample carrier and / or capable of bearing the first sample carrier and the second sample carrier in a time-sharing manner; The first sample carrier and the second sample carrier are used to carry samples in different forms; An imaging module is disposed relative to the stage, and the imaging module is capable of capturing images of samples in a first sample carrier and / or a second sample carrier located on the bearing position, so as to obtain sample images of the samples in the first sample carrier and / or the samples in the second sample carrier. The system includes a control unit connected to the imaging module. The control unit is capable of analyzing the sample image and obtaining detection results for the sample in the first sample carrier and / or for the sample in the second sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

2. The sample analysis device of claim 1, wherein, The first sample carrier has a planar support structure for carrying the sample; and / or the second sample carrier has a support structure for carrying the sample that includes at least one cavity.

3. The sample analysis device of claim 2, wherein, The first sample carrier is a plate-shaped slide structure, and the plane on the outer wall of the slide is used to support the sample; And / or, the second sample carrier is a box structure, the cavity of the box structure having at least one opening and at least one flow channel for carrying the sample, the opening being in communication with the flow channel.

4. The sample analysis device of any one of claims 1-3, wherein, The carrier position is at least two, at least one of which is a first carrier position capable of carrying the first sample carrier, and at least one of which is a second carrier position capable of carrying the second sample carrier.

5. The sample analysis device of claim 4, wherein, It also includes a transfer mechanism for driving the first carrier position and / or the second carrier position to move relative to the imaging module, so that the first carrier position can move into the imaging range of the imaging module and / or the second carrier position can move into the imaging range of the imaging module.

6. The sample analysis device of claim 5, wherein The first bearing position and / or the second bearing position move in a horizontal direction, and the imaging module is located above or below the movement trajectory of the first bearing position and / or the second bearing position.

7. The sample analysis device of claim 4, wherein The imaging module includes at least a first imaging module and a second imaging module. The first imaging module is configured correspondingly to the first carrier position and is used to capture the sample in the first sample carrier. The second imaging module is configured correspondingly to the second carrier position and is used to capture the sample in the second sample carrier.

8. The sample analysis device of claim 4, wherein, It also includes a transfer mechanism. The imaging module is a set of shared imaging modules. The transfer mechanism is used to drive the imaging module to move relative to the first carrier position and / or the second carrier position, so that the imaging module can move to a position opposite to the first carrier position to photograph the sample in the first sample carrier, and / or enable the imaging module to move to a position opposite to the second carrier position to photograph the sample in the second sample carrier.

9. The sample analysis device of any one of claims 1-3, wherein, At least one of the bearing positions is a shared bearing position, and the shared bearing position has a shared bearing structure that can bear both the first sample carrier and the second sample carrier.

10. The sample analysis device of claim 9, wherein, The imaging module is a set of shared imaging modules, which are arranged opposite to the shared carrier position. The shared imaging module can be used to capture samples in the first sample carrier located on the shared carrier position, and can also capture samples in the second sample carrier located on the shared carrier position.

11. The sample analysis device of any one of claims 1-10, wherein, It also includes an illumination module, which is located on both sides of the bearing position, and the illumination module is used to illuminate the first sample carrier and / or the second sample carrier on the bearing position to help the imaging module to capture the samples in the first sample carrier and / or the second sample carrier.

12. The sample analysis device of any one of claims 1-11, wherein, It also includes a sample pretreatment module, which has a pipetting assembly for pretreatment of samples in the first sample carrier and / or the second sample carrier.

13. The sample analysis device of any one of claims 1-12, wherein, At least one carrier position is divided into a pre-processing area and / or a detection area. The sample carried in the pre-processing area is used for pre-processing by the corresponding pre-processing module, and the sample carried in the detection area is used for imaging by the imaging module.

14. The sample analysis device of any one of claims 1-13, wherein, There are two or more bearing positions, and each bearing position is located on the same platform. Alternatively, there may be two or more bearing positions, and the platform may be divided into multiple sub-platforms, each of which may have at least one bearing position.

15. A sample analysis device, characterized by, include: A stage, wherein the stage has a bearing position capable of simultaneously bearing at least two sample carriers; The sample carriers described may have the same or different shapes for carrying the samples; An imaging module is provided, which is positioned relative to the stage, and is capable of capturing images of samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier. The system includes a control unit connected to the imaging module. The control unit is capable of analyzing the sample images and obtaining detection results for the samples in each of the sample carriers. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

16. The sample analysis device of claim 15, wherein, The sample carrier is a first sample carrier, which is a slide structure. The slide structure is a planar support structure for carrying the sample. Alternatively, the sample carrier may be a second sample carrier, which is a box structure, and the box structure for carrying the sample includes at least one cavity.

17. The sample analysis device of any one of claims 1-16, wherein, The samples carried by the first sample carrier include blood samples, skin samples, and / or pathological slide samples; And / or, the samples carried by the second sample carrier include blood samples, feces, urine samples, ear canal secretion samples and / or fine needle aspiration samples.

18. A sample analysis device, characterized by, include: A stage having a bearing position for simultaneously or at different times bearing a first sample carrier and a second sample carrier; The first sample carrier and the second sample carrier are used to carry samples in different forms; An imaging module is provided, which is positioned relative to the stage, and is capable of capturing images of samples in the sample carriers located on the support position to obtain sample images of the samples in each sample carrier. and a control unit, which is signal-connected to the imaging module; The control unit has a first operating mode and a second operating mode; In the first operating mode, the control unit controls the imaging module to capture images of the sample in the first sample carrier located on the bearing position, obtain sample images, and analyzes the sample images to obtain detection results about the sample in the first sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification. In the second operating mode, the control unit controls the imaging module to capture images of the sample in the second sample carrier located on the bearing position, obtain sample images, and analyzes the sample images to obtain detection results about the sample in the second sample carrier. The detection results include at least one of particle count, particle morphology characterization, and particle classification.

19. The sample analysis device of claim 18, wherein, In the first operating mode, the control unit calls the corresponding first algorithm unit to analyze the sample image and obtain the detection result of the sample in the first sample carrier; And / or, in the second operating mode, the control unit calls the corresponding second algorithm unit to analyze the sample image and obtain the detection result of the sample in the second sample carrier.

20. The sample analysis device of claim 18 or 19, wherein, It also includes an operating mode selection module, which is signal-connected to the control unit, and allows the user to select to run the first operating mode and / or the second operating mode.

21. The sample analysis device of claim 20, wherein, The operating mode selection module includes a human-computer interaction module, which has a display component for displaying relevant information about the first operating mode and the second operating mode for the user to select.

22. The sample analysis device of claim 21, wherein, The information related to the first operating mode and the information related to the second operating mode displayed by the display component both include the mode name, the type of sample being tested, and at least one of the testing items.

23. The sample analysis device of any one of claims 18-22, wherein, The first sample carrier is a slide structure, and the slide structure used to support the sample is a planar structure; And / or, the second sample carrier is a box structure, the box structure for carrying the sample includes at least one cavity.

24. The sample analysis device of any one of claims 18-23, wherein, The control unit determines the operating mode according to the following rules: The mapping relationship between the preset sample types and / or detection items in the device and the first operating mode and the second operating mode; The system receives user input instructions, which indicate the sample type and / or detection items of the sample. Based on the correspondence between the sample type and / or detection items indicated by the instructions in the mapping relationship, the system determines whether to run the first running mode or the second running mode.

25. The sample analysis apparatus according to any one of claims 18-24, characterized in that, The sample types applicable to the first operating mode include blood, skin, and / or pathological sections; And / or, the sample types applicable to the second operating mode include blood, feces, urine, ear canal secretions, and / or fine needle aspiration.

26. The sample analysis apparatus according to any one of claims 18-25, characterized in that, The detection parameters applicable to the first operating mode include blood sample detection parameters, skin sample detection parameters and / or pathological section sample detection parameters. The blood sample detection parameters include anemia classification and / or blood parasites. The skin sample detection parameters include mites, lice, fleas, ticks, protozoa, bacteria and / or fungi or spores. The pathological section sample detection parameters include tumors, mitotic figures and / or tissue and cell damage. And / or, the detection parameters applicable to the samples in the second operating mode include blood sample detection parameters, fecal sample detection parameters, urine sample detection parameters, ear canal secretion sample detection parameters, and / or fine needle aspiration sample detection parameters; the blood sample detection parameters include red blood cell count, shadow red blood cells, nucleated red blood cells, abnormal red blood cells, reticulocytes, white blood cell count and differential, platelet count and differential, and / or platelet aggregation; the fecal detection parameters include parasites, digestive products, bacteria and fungi, cells, and / or plant fibers; the urine sample detection parameters include cells, casts, crystals, and / or bacteria and fungi; the ear canal secretion sample detection parameters include bacteria and fungi and / or ear mites; and the fine needle aspiration sample detection parameters include normal cells, tumor cells, and / or microorganisms.

Images