toothpaste

Abstract

A toothpaste. The toothpaste comprises, by mass fraction, at least 5% to 20% of hydrated silica and 5% to 15% of zeolite, wherein the hydrated silica has an average particle size of R1 and a Brinell hardness of H1, and the zeolite has an average particle size of R2 and a Brinell hardness of H2; 20 μm ≤ R1 ≤ 40 μm, 1 μm ≤ R2 ≤ 10 μm, 5 ≤ R1 / R2 ≤ 20, 2.5 HB ≤ H1 ≤ 3.5 HB, 4.0 HB ≤ H2 ≤ 6 HB, and 1.3 ≤ H2 / H1 ≤ 2.

Description

toothpaste

[0001] Related applications

[0002] This application claims priority to Chinese patent application No. 202510125178.7, filed on January 26, 2025, entitled "Toothpaste", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of oral care technology, and in particular to toothpaste. Background Technology

[0004] Toothpaste, as an oral hygiene product, cleans the mouth, prevents cavities, and keeps breath fresh. Its main ingredients include abrasives, humectants, and surfactants. Abrasives, a crucial component of toothpaste, primarily remove dirt and plaque from the tooth surface, whitening teeth. However, if the abrasive's friction is insufficient, the whitening effect will be minimal, resulting in poor cleaning. Conversely, if the abrasive's friction is too strong, it can damage the tooth surface and periodontal tissues, causing harm. Furthermore, conditions such as gingivitis and periodontitis can cause inflamed gums that bleed easily upon touch. Brushing too vigorously or using a toothbrush with overly hard bristles can also damage the gums and cause bleeding. However, most toothpastes use medicinal ingredients to stop the bleeding. Summary of the Invention

[0005] According to various embodiments of this application, a toothpaste is provided.

[0006] A toothpaste, by mass fraction, comprises at least 5% to 20% hydrated silica and 5% to 15% zeolite, wherein the hydrated silica has an average particle size of R1 and a Brinell hardness of H1, the zeolite has an average particle size of R2 and a Brinell hardness of H2, and 20μm≤R1≤40μm, 1μm≤R2≤10μm, 5≤R1 / R2≤20, 2.5HB≤H1≤3.5HB, 4.0HB≤H2≤6HB, and 1.3≤H2 / H1≤2.

[0007] In one embodiment, 4.0HB≤H2≤5.5HB.

[0008] In one embodiment, the mass fraction of hydrated silica in the toothpaste is less than or equal to the mass fraction of zeolite.

[0009] In one embodiment, the mass ratio of the hydrated silica to the zeolite is 1:1 to 1:3.

[0010] In one embodiment, the zeolite has a specific surface area greater than or equal to 50 m². 2 / g-1 ; and / or, the pore size of the zeolite is greater than or equal to 0.5 nm.

[0011] In one embodiment, the zeolite contains 0.5% to 3% calcium ions by mass.

[0012] In one embodiment, the zeolite is also loaded with strontium ions.

[0013] In one embodiment, 20μm≤R1≤30μm, 5μm≤R2≤10μm, and 1.5≤H2 / H1≤2.

[0014] In one embodiment, the strontium ion mass fraction in the zeolite is 0.2% to 2.0%.

[0015] In one embodiment, the mass ratio of strontium ions to calcium ions in the zeolite is 1:1 to 4:1.

[0016] Details of one or more embodiments of this application are set forth in the following drawings and description. Other features, objects, and advantages of this application will become apparent from the specification, drawings, and claims. Detailed Implementation

[0017] To facilitate understanding of this application, it will be described in more detail below. However, it should be understood that this application can be implemented in many different forms and is not limited to the embodiments or examples described herein. Rather, these embodiments or examples are provided to provide a more thorough and complete understanding of the disclosure of this application.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the specification of this application is for the purpose of describing particular implementations or embodiments only and is not intended to be limiting of this application. The optional range of the term "and / or" as used herein includes any one of two or more of the related listed items, as well as any and all combinations of the related listed items, including any two related listed items, any more related listed items, or a combination of all related listed items.

[0019] In this application, numerical ranges are referred to as continuous unless otherwise specified, and include the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.

[0020] Currently, commonly used toothpaste abrasives mainly include hydrated silica (silica), calcium carbonate, dicalcium phosphate, calcium pyrophosphate, or aluminum hydroxide. Each abrasive has different abrasive effects due to its particle size and hardness. To ensure the toothpaste's cleaning effect without damaging teeth due to excessive abrasion, the toothpaste provided in this application includes at least hydrated silica and zeolite, using a blend of hydrated silica and zeolite as an abrasive. The hardness of hydrated silica is generally lower than that of zeolite. Considering the characteristics of hydrated silica and zeolite, the toothpaste of this application meets the following conditions:

[0021] First, the mass fraction of hydrated silica in the toothpaste is controlled to be between 5% and 20%, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, etc. The average particle size R1 of the hydrated silica is controlled to be within the range of 20μm to 40μm, for example, 20μm, 21μm, 22μm, 23μm, 24μm, 25μm, 26μm, 27μm, 28μm, etc. The Brinell hardness H1 of hydrated silica is controlled within the range of 2.5HB to 3.5HB, for example, 2.5HB, 2.6HB, 2.7HB, 2.8HB, 2.9HB, 3.0HB, 3.1HB, 3.2HB, 3.3HB, 3.4HB, 3.5HB, etc., with values ​​of m, 29μm, 30μm, 31μm, 32μm, 33μm, 34μm, 35μm, 36μm, 37μm, 38μm, 39μm, 40μm, etc.

[0022] Secondly, the mass fraction of zeolite in the toothpaste is controlled to be between 5% and 15%, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.; the average particle size R2 of the zeolite is controlled to be within the range of 1μm to 10μm, for example, 1μm, 2μm, 3μm, 4μm, 5μm, 6μm, 7μm, 8μm, 9μm, 10μm, etc.; and the Brinell hardness H2 of the zeolite is controlled. Within the range of 4.0HB to 6.0HB, such as 4.0HB, 4.1HB, 4.2HB, 4.3HB, 4.4HB, 4.5HB, 4.6HB, 4.7HB, 4.8HB, 4.9HB, 5.0HB, 5.1HB, 5.2HB, 5.3HB, 5.4HB, 5.5HB, 5.6HB, 5.7HB, 5.8HB, 5.9HB, 6.0HB, etc.

[0023] Meanwhile, the particle size ratio R1 / R2 of hydrated silica and zeolite is further controlled to be 5 to 20, for example, R1 / R2 is 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, etc., and the Brinell hardness ratio H2 / H1 of zeolite and hydrated silica is 1.3 to 2, for example, H2 / H1 is 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, etc.

[0024] Therefore, by using hydrated silica and zeolite as a compound abrasive in toothpaste, and by controlling the particle size, Brinell hardness, and content of hydrated silica and zeolite to achieve synergy, when used, the hydrated silica drives the zeolite to roll and mechanically rub against the tooth surface, similar to the effect of a large gear driving a small gear, rather than the effect of friction alone. In this way, the cleaning effect can be guaranteed, while avoiding excessive friction that could damage the teeth.

[0025] In addition, zeolite has excellent adsorption and hemostatic properties, and can assist in hemostasis by adsorption and promoting wound healing. When the toothpaste of this application uses zeolite as an abrasive, it can better assist in hemostasis under the friction driven by hydrated silica.

[0026] Furthermore, controlling the Brinell hardness H2 of zeolite within the range of 4.0HB to 5.5HB can more effectively prevent excessive friction from damaging teeth.

[0027] In the toothpaste of this application, the average particle size of hydrated silica is relatively large, while the average particle size of zeolite is relatively small. Considering the Brinell hardness characteristics of hydrated silica and zeolite, in some embodiments, when the mass ratio of zeolite in the toothpaste is greater than that of hydrated silica, the mechanical friction effect of hydrated silica driving zeolite to roll on the tooth surface is better during use. Furthermore, in some embodiments, the mass ratio of hydrated silica to zeolite is 1:1 to 1:3, such as 1:1, 1:1.5, 1:2, 1:2.5, 1:3, etc.

[0028] Furthermore, in some embodiments, the specific surface area of ​​the zeolite is greater than or equal to 50 m². 2 / g; and / or, in some embodiments, the pore size of the zeolite is greater than or equal to 0.5 nm, which enables the zeolite to better adsorb plaque, pigments and odors on the tooth surface, helping to clean the tooth surface, maintain oral hygiene, and better assist in hemostasis.

[0029] When zeolite assists in hemostasis, the effect is related to the concentration of calcium ions released. In this application, because the zeolite rolls and rubs under the influence of hydrated silica, in some embodiments, the mass fraction of calcium ions in the zeolite is 0.5%-3%, such as 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, etc. The concentration of calcium ions in the oral cavity is optimal, resulting in rapid hemostasis and excellent efficacy.

[0030] Dentin hypersensitivity refers to the pain experienced when the enamel (also known as dentin) of teeth gradually wears down to expose the dentin, triggered by stimuli such as temperature, mechanical, or chemical stimuli. For example, it can cause a momentary sharp pain when consuming sugary foods, acidic fruits, or drinking cold water. Currently, strontium salts are commonly used as desensitizing agents in toothpaste. However, when the content of strontium salts or other desensitizing agents in toothpaste is high, the toothpaste may taste unpleasant.

[0031] In this application, furthermore, in some embodiments, the zeolite is also loaded with strontium ions. Since the toothpaste of this application generates hydrated silica during use, which drives the zeolite to roll and mechanically rub against the tooth surface, the zeolite of this application can dynamically and continuously release strontium ions, ensuring that the concentration of strontium ions in the oral environment remains relatively stable. This avoids the problem of poor taste caused by excessive concentration, improving the taste, and also ensures that strontium ions can be continuously and stably adsorbed onto the enamel and dentin, reacting with carbonate ions to form insoluble strontium carbonate (SrCO3), and reacting with hydroxyapatite in dentin to form hydroxystrontium apatite (Ca3(PO4)Sr(OH)2). This hydroxyapatite has the effect of sealing dentinal tubules and mineralizing dentin, thereby slowing down the transmission of stimuli and improving the teeth's anti-sensitivity ability. It should be noted that this is a continuous and stable process, therefore the resulting anti-sensitivity effect is better.

[0032] To improve the effective friction and cleaning of teeth during brushing by having zeolite roll rapidly on the tooth surface driven by hydrated silica, and to dynamically and continuously release strontium ions, ensuring that strontium ions in the oral environment are adsorbed by dentin and seal dentinal tubules in a short time during brushing, in some embodiments, the average particle size R1 of hydrated silica is 20 μm to 30 μm, the average particle size R2 of zeolite is 5 μm to 10 μm, and the Brinell hardness ratio H2 / H1 of zeolite and hydrated silica is 1.5 to 2.

[0033] Furthermore, the mass fraction of strontium ions in zeolite is 0.2%-2.0%, such as 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, etc., which can better control the concentration of strontium ions in the oral environment.

[0034] It is understandable that strontium ions in zeolite can be obtained by impregnating zeolite with strontium salts such as strontium chloride and strontium nitrate, and the concentration of strontium ions in zeolite can be adjusted by regulating the concentration of strontium salts and the number of impregnation cycles. Similarly, although zeolite itself contains calcium ions, the calcium ion content in zeolite can also be adjusted by impregnating zeolite with calcium salts such as calcium chloride.

[0035] Furthermore, in some embodiments, the mass ratio of strontium ions to calcium ions in the zeolite is 1:1 to 4:1, which can make the anti-allergy effect and hemostatic effect of the toothpaste reach a better state.

[0036] It is understandable that toothpaste contains not only abrasives, but also humectants, thickeners, surfactants, and fragrances, such as xanthan gum, glycerin, sorbitol, and sodium lauryl sulfate, which will not be described in detail here.

[0037] The toothpaste will be further explained below through specific examples.

[0038] Example 1

[0039] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0040] Example 2

[0041] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 20 μm, Brinell hardness H1 is 2.5 HB), 7.05% zeolite (particle size R2 is 4 μm, Brinell hardness H2 is 4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0042] Example 3

[0043] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 40 μm, Brinell hardness H1 is 3.5 HB), 7.05% zeolite (particle size R2 is 2 μm, Brinell hardness H2 is 6 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0044] Example 4

[0045] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 35 μm, Brinell hardness H1 is 2.8 HB), 7.05% zeolite (particle size R2 is 3 μm, Brinell hardness H2 is 5 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0046] Example 5

[0047] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 40 μm, Brinell hardness H1 is 3.2 HB), 7.05% zeolite (particle size R2 is 8 μm, Brinell hardness H2 is 4.16 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0048] Example 6

[0049] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 25 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 2 μm, Brinell hardness H2 is 4.5 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0050] Comparative Example 1

[0051] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 18.33% hydrated silica (particle size R1 of 30 μm, Brinell hardness H1 of 3HB), and 0.07% titanium dioxide (CI77891).

[0052] Comparative Example 2

[0053] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 18.33% zeolite (particle size R2 of 5 μm, Brinell hardness H2 of 5.4 HB, and calcium ion mass fraction of 2%), and 0.07% titanium dioxide (CI77891).

[0054] Comparative Example 3

[0055] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 14.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 3 HB), 4.05% zeolite (particle size R2 5 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0056] Comparative Example 4

[0057] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 4.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 3 HB), 14.05% zeolite (particle size R2 5 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0058] Comparative Example 5

[0059] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 3 HB), 7.05% zeolite (particle size R2 10 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0060] Comparative Example 6

[0061] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 3 HB), 7.05% zeolite (particle size R2 1 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0062] Comparative Example 7

[0063] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 20 μm, Brinell hardness H1 3 HB), 7.05% zeolite (particle size R2 5 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0064] Comparative Example 8

[0065] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 2.5 HB), 7.05% zeolite (particle size R2 5 μm, Brinell hardness H2 5.4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0066] Comparative Example 9

[0067] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 30 μm, Brinell hardness H1 3.5 HB), 7.05% zeolite (particle size R2 5 μm, Brinell hardness H2 4 HB, calcium ion mass fraction 2%), and 0.07% titanium dioxide (CI77891).

[0068] The toothpastes of Examples 1 to 6 and Comparative Examples 1 to 9 were compared in terms of performance. The Lobene stain area index after 8 weeks of use by patients with extrinsically stained teeth was used to compare the cleaning (whitening) effect. Hard particles were detected according to method 5.7 of GB / T 8372-2017 standard to reflect the damage of toothpaste to teeth. The hemostasis effect was detected by in vitro coagulation time. The results are shown in Table 1.

[0069] Table 1

[0070] As shown in Table 1, by using hydrated silica and zeolite as abrasives in toothpaste and by controlling the particle size, Brinell hardness and content of hydrated silica and zeolite to achieve synergistic effects, it is possible to ensure cleaning effect, avoid excessive friction that could damage teeth, and also have hemostatic function.

[0071] Example 7

[0072] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 12.72% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 5.61% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0073] Example 8

[0074] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 9.41% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 8.92% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0075] Example 9

[0076] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 7.8% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 10.53% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0077] Example 10

[0078] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 6.92% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 11.41% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0079] Example 11

[0080] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 5.15% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 13.18% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, and the mass fraction of calcium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0081] The toothpastes from Examples 7 to 11 were compared in performance using the same method as described above, and the results are shown in Table 2.

[0082] Table 2

[0083] As shown in Table 2, the toothpaste is more effective when the mass percentage of zeolite in the toothpaste is greater than that of hydrated silica.

[0084] Example 12

[0085] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, calcium ion mass fraction is 0.5%, strontium ion mass fraction is 0.2%), and 0.07% titanium dioxide (CI77891).

[0086] Example 13

[0087] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, calcium ion mass fraction is 1%, strontium ion mass fraction is 0.5%), and 0.07% titanium dioxide (CI77891).

[0088] Example 14

[0089] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, calcium ion mass fraction is 1%, strontium ion mass fraction is 1.5%), and 0.07% titanium dioxide (CI77891).

[0090] Example 15

[0091] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, calcium ion mass fraction is 0.5%, strontium ion mass fraction is 1.5%), and 0.07% titanium dioxide (CI77891).

[0092] Example 16

[0093] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3 HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4 HB, calcium ion mass fraction is 2%, strontium ion mass fraction is 2%), and 0.07% titanium dioxide (CI77891).

[0094] Example 17

[0095] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 35 μm, Brinell hardness H1 is 3HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 5.4HB, mass fraction of calcium ions is 2%, mass fraction of strontium ions is 2%), and 0.07% titanium dioxide (CI77891).

[0096] Example 18

[0097] By mass fraction, the toothpaste in this embodiment mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 11.28% hydrated silica (particle size R1 is 30 μm, Brinell hardness H1 is 3HB), 7.05% zeolite (particle size R2 is 5 μm, Brinell hardness H2 is 4HB, calcium ion mass fraction is 2%, strontium ion mass fraction is 2%), and 0.07% titanium dioxide (CI77891).

[0098] According to the method of YY / T 1829-2022, the toothpaste of Comparative Examples 1 to 2 and the toothpaste of Examples 12 to 18 were tested for tubular sealing performance. At the same time, the hemostasis time was tested according to the above method. The results are shown in Table 3.

[0099] Table 3

[0100] Table 3 shows that after strontium ions are added to the zeolite, the toothpaste has the effect of sealing dentinal tubules and mineralizing dentin, thereby improving the tooth's anti-sensitivity ability. Furthermore, by optimizing the concentrations of strontium and calcium ions, as well as optimizing the particle size and Brinell hardness of hydrated silica and zeolite, the hemostatic effect and anti-sensitivity ability of the toothpaste can be further improved.

[0101] Comparative Example 10

[0102] By mass fraction, the toothpaste in this comparative example mainly consists of 0.28% xanthan gum, 15.52% water, 58.16% sorbitol, 3.52% polyethylene glycol-400, 0.70% glycerin, 0.42% cellulose gum, 0.35% sodium pyrophosphate, 0.10% triclogalactose, 0.08% sodium benzoate, 0.99% sodium lauryl sulfate, 0.78% fragrance, 0.70% zinc citrate, 18.33% zeolite (particle size R2 of 5 μm, Brinell hardness H2 of 5.4 HB, calcium ion mass fraction of 2%, strontium ion mass fraction of 2%), and 0.07% titanium dioxide (CI77891).

[0103] The toothpastes of Example 16 and Comparative Example 10 were subjected to taste tests. The test method involved selecting 50 volunteers and dividing them into two groups of 25 each. Each group used one toothpaste from Example 16 and the other from Comparative Example 10, and the taste was evaluated. The results showed that all volunteers using the toothpaste from Example 16 reported a good taste, while among the volunteers using the toothpaste from Comparative Example 10, 8 reported a neutral taste and 17 reported a poor taste. This demonstrates that the abrasive combination of this application can dynamically and continuously release strontium ions from zeolite, ensuring a relatively stable concentration of strontium ions in the oral cavity, avoiding the problem of poor taste caused by excessively high concentrations, and thus improving the taste.

[0104] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0105] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A toothpaste, characterized in that, The hydrated silica comprises, by mass fraction, at least 5% to 20% hydrated silica and 5% to 15% zeolite, wherein the average particle size of the hydrated silica is R1, the Brinell hardness of the hydrated silica is H1, the average particle size of the zeolite is R2, the Brinell hardness of the zeolite is H2, and 20μm≤R1≤40μm, 1μm≤R2≤10μm, 5≤R1 / R2≤20, 2.5HB≤H1≤3.5HB, 4.0HB≤H2≤6HB, and 1.3≤H2 / H1≤2.

2. The toothpaste according to claim 1, wherein, 4.0HB≤H2≤5.5HB.

3. The toothpaste according to claim 1, wherein, The mass fraction of hydrated silica in the toothpaste is less than or equal to the mass fraction of zeolite.

4. The toothpaste according to claim 3, wherein, The mass ratio of the hydrated silica to the zeolite is 1:1 to 1:

3.

5. The toothpaste according to claim 1, wherein, The specific surface area of ​​the zeolite is greater than or equal to 50 m². 2 / g; and / or, the pore size of the zeolite is greater than or equal to 0.5 nm.

6. The toothpaste according to any one of claims 1 to 5, wherein, The zeolite contains 0.5% to 3% calcium ions by mass.

7. The toothpaste according to any one of claims 1 to 5, wherein, The zeolite is also loaded with strontium ions.

8. The toothpaste according to claim 7, wherein, 20μm≤R1≤30μm, 5μm≤R2≤10μm, 1.5≤H2 / H1≤2.

9. The toothpaste according to claim 7, wherein, The strontium ion mass fraction in the zeolite is 0.2% to 2.0%.

10. The toothpaste according to claim 9, wherein, The mass ratio of strontium ions to calcium ions in the zeolite is 1:1 to 4:1.

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