Repair composition, facial repair cream, and use thereof

Abstract

The present disclosure relates to a repair composition, a facial repair cream, and use thereof, belonging to the technical field of cosmetics. The repair composition comprises: allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, an anti-sensitivity agent, and a hydrosol, wherein the anti-sensitivity agent comprises octyldodecanol, echium plantagineum seed oil, sunflower seed oil unsaponifiable, a Cardiospermum halicacabum flower / leaf / vine extract, and tocopherol; and the hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and a soluble collagen. The skin barrier can be significantly improved, reducing percutaneous water loss, and achieving a significant repair effect.

Description

A repair composition, a repair cream and its application

[0001] Cross-reference to related applications

[0002] This disclosure claims priority to Chinese Patent Application No. 2025101209652, filed on January 24, 2025, entitled "A Repairing Composition, a Repairing Cream and Its Application", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This disclosure relates to the field of cosmetic technology, and particularly to a repair composition, a repair cream, and its application. Background Technology

[0004] The skin, the largest organ covering the human body, plays a vital role in protecting against harmful external environments and safeguarding the body's health. Its structural integrity and normal function are crucial for maintaining overall health. In recent years, due to changes in the external natural environment and the overemphasis on efficacy-driven skincare, more and more consumers are experiencing skin barrier damage. Damaged skin barriers can lead to symptoms such as burning, stinging, itching, peeling, tightness, and redness. Prolonged damage can develop into sensitive skin and even trigger inflammatory skin diseases such as atopic dermatitis.

[0005] Currently, ceramides are often used in combination with other ingredients to soothe and repair the skin. However, ceramides can only provide exogenous moisturizing effects and are expensive. They are usually added in low amounts and have a weak soothing and repairing effect on the skin. Summary of the Invention

[0006] To address the shortcomings of existing technologies, the present disclosure aims to provide a repair composition, a repair cream, and their application. These components can effectively improve the skin barrier, reduce transepidermal moisture loss, and exhibit significant repairing effects.

[0007] In a first aspect, embodiments of this disclosure provide a repair composition comprising: allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, an anti-allergen, and a hydrosol; wherein the anti-allergen comprises octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol; and the hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

[0008] The cetyl-PG hydroxyethyl palmitamide disclosed herein is a ceramide-like substance with equivalent efficacy to ceramides but at a lower price. In addition to providing exogenous moisturizing effects, it is compounded with allantoin, acetylated sodium hyaluronate, anti-allergens, and a hydrosol. The anti-allergens include octyl dodecanol, *Artichoke solanum* seed oil, sunflower seed oil unsaponifiables, *Lysimachia christinae* flower / leaf / vine extract, and tocopherol. The hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen. It can simultaneously promote epidermal cell proliferation, repair damaged epidermal cells, soothe and protect irritated sensitive skin, and replenish skin collagen, thereby effectively improving the skin barrier, reducing transepidermal water loss, and exhibiting significant repairing effects.

[0009] In some embodiments of this disclosure, the repair composition comprises, by weight: 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts anti-allergy agent, and 0.1-5 parts hydrosol.

[0010] This disclosure further employs allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, anti-allergen and hydrosol in appropriate proportions to further synergistically improve the skin barrier and significantly repair the skin.

[0011] Secondly, embodiments of this disclosure provide a repair composition comprising 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts an anti-allergy agent, and 0.1-5 parts a hydrosol; wherein the anti-allergy agent comprises octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol; and the hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

[0012] This disclosure uses only cetyl-PG hydroxyethyl palmitamide, allantoin, acetylated sodium hyaluronate, an anti-allergen, and a hydrosol. The anti-allergen consists of octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol. The hydrosol consists of water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen. In addition to providing exogenous moisturizing effects, it also promotes epidermal cell proliferation, repairs damaged epidermal cells, soothes and protects irritated sensitive skin, and replenishes skin collagen, thereby effectively improving the skin barrier, reducing transepidermal water loss, and exhibiting significant repair effects.

[0013] Thirdly, embodiments of this disclosure provide the use of the repair composition as provided in the first or second aspect in the preparation of cosmetics or pharmaceuticals having repairing effects.

[0014] This disclosure uses the above-mentioned repair composition to prepare cosmetics or pharmaceuticals. Since the above-mentioned repair composition can effectively improve the skin barrier and reduce transepidermal water loss, it has a significant repair effect. Therefore, cosmetics or pharmaceuticals prepared using this repair composition also have a more significant and obvious repair effect on the skin barrier.

[0015] Fourthly, embodiments of this disclosure provide a repair cream comprising the repair composition provided in the first or second aspect; the repair composition constitutes 0.76%-12.4% of the repair cream by mass.

[0016] The repair cream disclosed herein includes the above-mentioned repair composition in an appropriate weight percentage. Since the above-mentioned repair composition can effectively improve the skin barrier and reduce transepidermal water loss, it has a significant repair effect. Therefore, the repair cream including the repair composition also has a more significant and noticeable repair effect on the skin barrier.

[0017] In some embodiments of this disclosure, the repair cream includes emollients, emollient powders, emulsifiers, and solid oils; wherein the emollients include hydrogenated coconut oil glycerides and jojoba esters; and the emollient powders include lauroyl lysine and cetyl palmitate.

[0018] This disclosure utilizes a repair cream incorporating emollients, emollient powders, emulsifiers, and solid oils. The emollients include hydrogenated coconut oil glycerides and jojoba esters; the emollient powders include lauroyl lysine and cetyl palmitate. This allows the cream to have a firm texture that melts quickly upon application, is smooth during application, and gradually breaks down and releases the oil phase upon further application, resulting in a moisturizing effect and a unique multi-sensory experience.

[0019] In some embodiments of this disclosure, the emulsifiers include cetearyl alcohol, stearyl alcohol polyether-21, and glyceryl stearate.

[0020] This disclosure uses cetearyl alcohol, stearyl alcohol polyether-21 and glyceryl stearate as emulsifiers, which are combined with the above-mentioned emulsifiers, emulsifying powders and solid oils to further give the face cream a moisturizing characteristic. It melts quickly when applied, is smooth when applied, and the cream gradually breaks down and releases the oil phase with continued application.

[0021] In some embodiments of this disclosure, the solid grease includes white beeswax.

[0022] This disclosure selects white beeswax as a solid oil, which, in combination with the above-mentioned emollients, emollient powders and emulsifiers, further gives the face cream a firm texture.

[0023] In some embodiments of this disclosure, the repair cream further includes excipients, which include at least one of moisturizers, thickeners, hydrating agents, emollients, antioxidants, protectants, preservatives, fragrances, and colorants.

[0024] This disclosure uses at least one of the above-mentioned excipients in combination with the above-mentioned repair composition, emollient, emollient powder, emulsifier and solid oil to form a face cream that has both repairing and moisturizing properties, and a unique multi-feel experience.

[0025] Fifthly, this disclosure provides a repairing face cream, which comprises, by weight percentage: allantoin 0.05%-0.3%, acetylated sodium hyaluronate 0.01%-0.1%, cetyl-PG hydroxyethyl palmitamide 0.1%-2%, an anti-allergy agent 0.5%-5%, a hydrosol 0.1%-5%, hydrogenated coconut oil glycerides 1%-2.5%, jojoba esters 1%-2.5%, lauroyl lysine 0.5%-3%, and cetyl palmitate. Palmitate 0.5%-1.5%, cetearyl alcohol 1.75%-3.25%, stearyl alcohol polyether-21 0.8%-1.5%, glyceryl stearate 1.5%-2.5%, white beeswax 0.5%-2%; the remainder is water; among which, the anti-allergy agents include octyl dodecanol, plantain leaf and artichoke seed oil, sunflower seed oil unsaponifiables, lysimachia flower / leaf / vine extract and tocopherol; the hydrosol includes water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate and soluble collagen.

[0026] The repair cream disclosed herein comprises a suitable percentage by weight of a repair composition, emollients, emollient powders, emulsifiers, and solid oils, thereby forming a cream that has both significant repair effects and moisturizing properties, providing a unique multi-sensory experience.

[0027] In some embodiments of this disclosure, the repair cream further includes 20.4%-59.9% by weight of excipients.

[0028] This disclosure uses appropriate weight percentages of excipients, combined with appropriate weight percentages of repairing compositions, emollients, softening powders, emulsifiers and solid oils, to form a face cream that has both significant repairing effects and moisturizing characteristics, providing a unique multi-sensory experience. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of the embodiments of this disclosure clearer, the technical solutions in the embodiments of this disclosure will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0030] This disclosure provides a repair composition comprising: allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, an anti-allergen, and a hydrosol; wherein the anti-allergen comprises octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol; and the hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

[0031] The cetyl-PG hydroxyethyl palmitamide used in this disclosure is a ceramide-like compound with equivalent efficacy to ceramides but at a lower price. In addition to providing exogenous moisturizing effects, it is compounded with allantoin, acetylated sodium hyaluronate, anti-allergens, and a hydrosol. The anti-allergens include octyl dodecanol, *Artichoke solanum* seed oil, sunflower seed oil unsaponifiables, *Lysimachia christinae* flower / leaf / vine extract, and tocopherol. The hydrosol includes water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen. Allantoin is an amphoteric compound that can bind to various substances to form complex salts, possessing photoprotective, antibacterial, antiseptic, analgesic, and antioxidant properties, and promoting skin health. The product enhances the water absorption capacity of the outermost layer of hair and strengthens the water-binding ability of keratinocytes. Acetylated sodium hyaluronate provides lipophilicity, promoting epidermal cell proliferation and repairing damaged epidermal cells. The anti-allergen is rich in unsaturated fatty acids (linolenic acid) and has a high content of unsaponifiable oils (phytosterols, vitamin E, and squalene), which can soothe and protect irritated sensitive skin, strengthen and reinforce the skin barrier, and has a powerful regenerative capacity for the skin barrier. The hydrosol replenishes skin collagen and enhances the skin barrier. Thus, through the synergistic effect of water solubility and oil solubility, it more effectively improves the skin barrier, reduces transepidermal water loss, and has significant repairing effects.

[0032] In some embodiments of this disclosure, the repair composition comprises, by weight: 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts anti-allergy agent, and 0.1-5 parts hydrosol. Further using appropriate proportions of allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, anti-allergy agent, and hydrosol synergistically improves the skin barrier and significantly repairs the skin.

[0033] This disclosure provides a repair composition comprising 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts an anti-allergy agent, and 0.1-5 parts a hydrosol. The anti-allergy agent comprises octyl dodecanol, *Ageratum cyrtonema* seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol. The hydrosol comprises water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

[0034] As an example, the allantoin in the repair composition may be, but is not limited to, 0.05 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.15 parts, 0.18 parts, 0.2 parts, 0.22 parts, 0.25 parts, 0.28 parts, or 0.3 parts. Acetylated sodium hyaluronate may be, but is not limited to, 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, or 0.1 parts. Cetyl-PG hydroxyethyl palmitamide may be, but is not limited to, 0.1 parts, 0.3 parts, 0.5 parts, 0.8 parts, 1 part, 1.3 parts, 1.5 parts, 1.8 parts, or 2 parts. The anti-allergen can be, but is not limited to, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, or 5 parts. The hydrosol can be, but is not limited to, 0.1 parts, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, or 5 parts.

[0035] As an example, the anti-sensitivity agent is Purchased from RAHN AG. It can also be formulated using octyl-dodecyl alcohol, *Cirsium japonicum* seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol. The hydrosol is HydroCol-y, purchased from Best Pharmaceuticals (Guangzhou) Co., Ltd. It can also be formulated using water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

[0036] This disclosure uses only cetyl-PG hydroxyethyl palmitamide, allantoin, acetylated sodium hyaluronate, an anti-allergen, and a hydrosol. The anti-allergen consists of octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol. The hydrosol consists of water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen. In addition to providing exogenous moisturizing effects, it also promotes epidermal cell proliferation, repairs damaged epidermal cells, soothes and protects irritated sensitive skin, and replenishes skin collagen, thereby effectively improving the skin barrier, reducing transepidermal water loss, and exhibiting significant repair effects.

[0037] This disclosure provides an example of the use of the repair composition described above in the preparation of cosmetics or pharmaceuticals with repairing effects.

[0038] This disclosure uses the above-mentioned repair composition to prepare cosmetics or pharmaceuticals. Since the above-mentioned repair composition can effectively improve the skin barrier and reduce transepidermal water loss, it has a significant repair effect. Therefore, cosmetics or pharmaceuticals prepared using this repair composition also have a more significant and obvious repair effect on the skin barrier.

[0039] This disclosure provides a repair cream comprising the above-described repair composition; the repair composition constitutes 0.76%-12.4% of the repair cream by weight.

[0040] As an example, the repair composition may be, but is not limited to, 0.76%, 0.8%, 0.95%, 1%, 2.5%, 3%, 5%, 6.5%, 8%, 9.5%, 10%, 11%, 12%, or 12.4% by weight in the repair cream.

[0041] The repair cream disclosed herein includes the above-mentioned repair composition in an appropriate weight percentage. Since the above-mentioned repair composition can effectively improve the skin barrier and reduce transepidermal water loss, it has a significant repair effect. Therefore, the repair cream including the repair composition also has a more significant and noticeable repair effect on the skin barrier.

[0042] In some embodiments of this disclosure, the repair cream includes an emollient, a softening powder, an emulsifier, and solid oils; wherein the emollient includes hydrogenated coconut oil glycerides and jojoba esters; and the softening powder includes lauroyl lysine and cetyl palmitate. The use of emollients, softening powders, emulsifiers, and solid oils in the repair cream, with the emollients being hydrogenated coconut oil glycerides and jojoba esters, and the softening powders being lauroyl lysine and cetyl palmitate, gives the cream a firm texture that melts quickly upon application, is smooth during application, and with continued application, gradually breaks down the emulsion and releases the oil phase, providing a moisturizing effect and a unique multi-sensory experience.

[0043] In some embodiments of this disclosure, the emulsifiers include cetearyl alcohol, stearyl alcohol polyether-21, and glyceryl stearate. The selection of cetearyl alcohol, stearyl alcohol polyether-21, and glyceryl stearate as emulsifiers, in combination with the aforementioned emollients, emollient powders, and solid oils, further enhances the cream's moisturizing properties. It melts quickly upon application, feels smooth during application, and with continued application, the cream gradually breaks down and releases its oil phase.

[0044] In some embodiments of this disclosure, the solid oil includes white beeswax. The selection of white beeswax as the solid oil, combined with the aforementioned emollients, emollient powders, and emulsifiers, further gives the face cream a firm texture.

[0045] In some embodiments of this disclosure, the repair cream further includes excipients, including at least one selected from moisturizers, thickeners, hydrating agents, emollients, antioxidants, protectants, preservatives, fragrances, and colorants. By using at least one of the above excipients in combination with the above-mentioned repair composition, emollients, emollient powders, emulsifiers, and solid oils, a cream is formed that possesses both repairing and moisturizing properties, offering a unique multi-sensory experience.

[0046] This disclosure provides a repairing face cream, which comprises, by weight percentage: allantoin 0.05%-0.3%, acetylated sodium hyaluronate 0.01%-0.1%, cetyl-PG hydroxyethyl palmitamide 0.1%-2%, anti-allergy agent 0.5%-5%, hydrosol 0.1%-5%, hydrogenated coconut oil glycerides 1%-2.5%, jojoba esters 1%-2.5%, lauroyl lysine 0.5%-3%, and cetyl palmitate. The composition includes esters 0.5%-1.5%, cetearyl alcohol 1.75%-3.25%, stearyl alcohol polyether-21 0.8%-1.5%, glyceryl stearate 1.5%-2.5%, and white beeswax 0.5%-2%; the remainder is water; among which, the anti-allergy agents include octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract and tocopherol; the hydrosol includes water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate and soluble collagen.

[0047] The repair cream disclosed herein comprises a suitable percentage by weight of a repair composition, emollients, emollient powders, emulsifiers, and solid oils, thereby forming a cream that has both significant repair effects and moisturizing properties, providing a unique multi-sensory experience.

[0048] In some embodiments of this disclosure, the repair cream further includes 20.4%-59.9% by weight of excipients. Using appropriate weight percentages of excipients, combined with appropriate weight percentages of repair compositions, emollients, softening powders, emulsifiers, and solid oils, a cream is formed that possesses both significant repairing efficacy and moisturizing properties, offering a unique multi-sensory experience.

[0049] As an example, the formula for the repair cream is shown in Table 1.

[0050] Table 1. Formula of Repair Cream

[0051] The features and performance of this disclosure will be further described in detail below with reference to embodiments.

[0052] Example 1

[0053] This embodiment provides a repair face cream, the specific formula of which is shown in Table 2:

[0054] Table 2. Formula of Repair Cream

[0055] This embodiment provides a method for preparing a repairing face cream, including:

[0056] (1) Add No. 31 and No. 32 to No. 33 in proportion, and disperse them evenly with an external homogenizer until there are no particles. Prepare the pre-raw material (A) for later use.

[0057] (2) After adding ingredient No. 1 to the water phase pot in proportion, start stirring at 1000 rpm. After adding ingredients No. 2, No. 3, No. 4, No. 5, No. 6, No. 7, No. 8 and No. 9, heat to 95℃ and keep warm for 20 minutes.

[0058] (3) Add ingredients No. 10, No. 11, No. 12, No. 13, No. 14, No. 15, No. 16, No. 17, No. 18, No. 19, No. 20, No. 21, No. 22, No. 23, No. 24 and No. 25 to the oil phase pot according to the proportion, start stirring at 1000 rpm, heat to 95℃, and keep warm for 15 minutes;

[0059] (4) Pump 3 / 4 of the aqueous phase material into the emulsifying pot, turn on the maximum stirring of the emulsifying pot, pump the oil phase material into the emulsifying pot, and then pump in the remaining 1 / 4 of the aqueous phase material. Vacuum -0.05Mpa, turn on the external circulation to homogenize for 8 minutes at 3000rpm. After homogenization, add raw material No. 26 and start cooling.

[0060] (5) Reduce the stirring speed to 55 rpm and cool to 40°C. Add No. 27, No. 28, No. 29, No. 30 and pre-made raw materials (A), No. 34 and No. 35, and keep the vacuum stirring for 15 min.

[0061] (6) After the sample passes the inspection, filter the material through a 100-mesh filter cloth at 38℃.

[0062] Example 2

[0063] This embodiment provides a repair face cream, the specific formula of which is shown in Table 3:

[0064] Table 3. Formulas of Repairing Face Creams

[0065] The preparation method of the repair cream provided in this embodiment is the same as that in Example 1.

[0066] Comparative Example 1

[0067] This embodiment provides a face cream that differs from Embodiment 2 in that it does not include components No. 8, No. 9, No. 24, No. 34 and No. 35 in the formula of the repair face cream of Embodiment 2 (see Table 3).

[0068] Comparative Example 2

[0069] This embodiment provides a face cream, which differs from Embodiment 2 in that it contains 0.01% by mass of hydrolyzed sodium hyaluronate (Nano). Enzymatically hydrolyzed oligomeric sodium hyaluronate (purchased from Bloomage Biotechnology Co., Ltd.) and 0.1% (w / w) Relipidium TM BC10096 (composed of hydrolyzed yeast protein, butanediol, and 1,2-pentanediol, purchased from BASF (China) Co., Ltd.).

[0070] Comparative Example 3

[0071] This embodiment provides a face cream, which differs from Embodiment 2 in that it uses... CB (composed of Edelweiss flower / leaf extract, glycerin, water, and citric acid, purchased from DSM Nutritional Products Ltd.) is a substitute for (Composed of octyldodecyl alcohol, Plantago asiatica seed oil, sunflower seed oil unsaponifiables, Lysimachia christinae flower / leaf / vine extract, and tocopherol, purchased from RAHN AG), with phytosphingosine replaced by cetyl-PG hydroxyethyl palmitamide, with the same percentage by weight.

[0072] Comparative Example 4

[0073] This embodiment provides a face cream that differs from Example 2 in that components No. 8, No. 9, No. 24, No. 34 and No. 35 in the formula of the repair face cream of Example 2 are replaced with 0.76% by mass of cetyl-PG hydroxyethyl palmitamide.

[0074] Comparative Example 5

[0075] This embodiment provides a face cream that differs from Embodiment 2 in that components No. 8, No. 9, No. 24, No. 34 and No. 35 in the formula of the repair face cream of Embodiment 2 are replaced with 0.66% by mass of cetyl-PG hydroxyethyl palmitamide and 0.1% by mass of allantoin.

[0076] Comparative Example 6

[0077] This embodiment provides a face cream, which differs from Example 2 in that components No. 8, No. 9, No. 24, No. 34, and No. 35 in the formula of the repair face cream of Example 2 are replaced with 0.21% cetyl-PG hydroxyethyl palmitamide, 0.05% allantoin, and 0.5% by mass. (Composed of octyldodecyl alcohol, plantain leaf and blue thistle seed oil, sunflower seed oil unsaponifiables, lysimachia flower / leaf / vine extract, and tocopherol).

[0078] Comparative Example 7

[0079] This embodiment provides a face cream that differs from Embodiment 2 in that the hydrogenated coconut oil glycerides in the formula of the repair face cream in Embodiment 2 are replaced with stearic acid, and lauroyl lysine is replaced with polymethyl silsesquioxane, while the mass percentage remains unchanged.

[0080] Experimental Example 1

[0081] This experimental example uses a patch test on the repair cream provided in Example 1. The specific method is as follows:

[0082] 0.020-0.025 mL of the repair cream provided in Example 1 was placed in a patch applicator and applied externally with hypoallergenic adhesive tape to the inside of the subject's arm. The test substance was removed after 24 hours, and skin reactions were observed at 0.5 hours, 24 hours, and 48 hours. An empty patch applicator was used as the blank control. Results were recorded according to the skin reaction grading standards in Chapter 7 of the 2015 edition of the *Cosmetic Safety Technical Specifications* for human patch experiments. There were 30 subjects (1 male and 29 females, aged 20-60 years). The skin reaction grading standards are shown in Table 4. The patch test results are shown in Table 5.

[0083] Table 4. Skin Reaction Grading Standards

[0084] Table 5. Results of Patch Test

[0085] As shown in Table 5, when each component of the repair cream in Example 1 was added at its maximum dosage, patch testing verified that the score of all 30 subjects was 0 after 0.5h, 24h, and 48h of removing the test substance patch apparatus. The score of the negative control patch apparatus was also 0 after 0.5h, 24h, and 48h of removal. This indicates that the repair cream provided in this disclosure is gentle and non-irritating.

[0086] Experimental Example 2

[0087] This experimental example tests the efficacy of the face creams provided in Examples 1-2 and Comparative Examples 1-6. The specific methods are as follows:

[0088] For 21 consecutive days, subjects randomly applied the repair cream provided in Examples 1-2 to one side of their left and right inner arms, while applying the cream provided in Comparative Examples 1-6 to the other side (follow-up follow-up was allowed to be adjusted to 1 day before or after the trial). Follow-up visits were conducted before the trial (D0) and after 21 days (D21). The stratum corneum moisture content of the skin on the inner sides of the randomly selected arms was measured, and the transepidermal water loss rate (TEWL) was calculated. Transepidermal water loss rate (%) = difference in water loss before and after / water loss before * 100. The results before and after product use were compared to determine if there was a statistically significant difference. The results are shown in Table 6.

[0089] Table 6. Results of the Repair Cream Efficacy Test

[0090] As shown in Table 6, the skin that used the repair creams provided in Examples 1-2 for 21 days had a lower transepidermal water loss rate; while the skin that used the creams provided in Comparative Examples 1 and 3-6 for 21 days had a higher transepidermal water loss rate. Furthermore, Comparative Example 2, based on Example 2, added hydrolyzed sodium hyaluronate and Relipidium. TM BC10096, but the transepidermal water loss rate of the skin after its use was not significantly different from that after the use in Example 2. This indicates that the repair cream provided in this disclosure uses a compound of cetyl-PG hydroxyethyl palmitamide, allantoin, acetylated sodium hyaluronate, an anti-allergen, and a hydrosol. The anti-allergen includes octyl dodecanol, *Imperata cylindrica* seed oil, sunflower seed oil unsaponifiables, *Imperata cylindrica* flower / leaf / vine extract, and tocopherol. The hydrosol includes water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen, which can effectively improve the skin barrier, reduce transepidermal water loss, and have significant repairing effects.

[0091] Experimental Example 3

[0092] This test case conducted a skin feel test on the repair creams provided in Example 1 and Comparative Example 7. The specific method was as follows: (1) Half an hour before the test, wash your hands and the inside of your forearms with clean water and wipe them clean with a clean face towel.

[0093] (2) Before use, use a syringe to take 0.2 mL of each of the repair creams to be tested onto a glass slide and observe the color and other indicators;

[0094] (3) When using, first take a 4*4cm area on the inside of the forearm as the test area, take 0.06mL of each test cream and apply it evenly to the test area. Use your fingertips to gently massage in circles at a frequency of 2 circles / s for 30s. Rinse with water and evaluate and record the various indicators as required. The results are shown in Table 7.

[0095] Table 7: Skin Feel of Repair Cream

[0096] As shown in Table 7, the repair cream provided in this disclosure, through the combined use of emollients, emollient powders, emulsifiers and solid oils, with the emollients being hydrogenated coconut oil glycerides and jojoba esters; and the emollient powders being lauroyl lysine and cetyl palmitate, has a firm texture that melts quickly upon application, is smooth during application, and gradually breaks down and releases the oil phase with continued application, exhibiting moisturizing characteristics and a unique multi-sensory experience.

[0097] The embodiments described above are some, but not all, of the embodiments of this disclosure. The detailed description of the embodiments of this disclosure is not intended to limit the scope of the claimed disclosure, but merely to illustrate selected embodiments of the disclosure. All other embodiments obtained by those skilled in the art based on the embodiments of this disclosure without inventive effort are within the scope of protection of this disclosure. Industrial applicability

[0098] This disclosure uses cetyl-PG hydroxyethyl palmitamide in combination with allantoin, acetylated sodium hyaluronate, an anti-allergen, and a hydrosol. The anti-allergen includes octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Heliotropium indicum* flower / leaf / vine extract, and tocopherol. The raw materials for the provided repair composition are readily available. After combination, it can effectively improve the skin barrier, reduce transepidermal water loss, and has significant repair effects. The preparation process is simple and easy to carry out, and it has good industrial applicability.

Claims

1. A repair composition, characterized in that, The repair composition includes: allantoin, acetylated sodium hyaluronate, cetyl-PG hydroxyethyl palmitamide, anti-allergy agent, and hydrosol; The anti-allergy agent includes octyl dodecanol, plantain leaf and blue thistle seed oil, sunflower seed oil unsaponifiables, lysimachia flower / leaf / vine extract and tocopherol; The hydrosol comprises water, glycerol, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

2. The repair composition according to claim 1, characterized in that, The repair composition comprises, by weight, 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts anti-allergy agent, and 0.1-5 parts hydrosol.

3. A repair composition, characterized in that, The repair composition consists of 0.05-0.3 parts allantoin, 0.01-0.1 parts acetylated sodium hyaluronate, 0.1-2 parts cetyl-PG hydroxyethyl palmitamide, 0.5-5 parts anti-allergy agent and 0.1-5 parts hydrosol; The anti-allergy agent is composed of octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, extracts of *Heliotropium indicum* flower / leaf / vine, and tocopherol. The hydrosol is composed of water, glycerol, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

4. The use of a repair composition as described in any one of claims 1-3 in the preparation of cosmetics or pharmaceuticals having repairing effects.

5. A repairing face cream, characterized in that, The product includes the repair composition according to any one of claims 1-3; the repair composition is present in the repair cream at a mass percentage of 0.76%-12.4%.

6. The repair cream according to claim 5, characterized in that, The repair cream includes emollients, emollient powders, emulsifiers, and solid oils; The emollients include hydrogenated coconut oil glycerides and jojoba esters; The skin-softening powder comprises lauroyl lysine and cetyl palmitate.

7. The repair cream according to claim 5 or 6, characterized in that, The emulsifiers include cetearyl alcohol, stearyl alcohol polyether-21, and glyceryl stearate; And / or, the solid grease includes white beeswax.

8. The repair cream according to claim 6 or 7, characterized in that, The repair cream also includes excipients, which include at least one of the following: moisturizer, thickener, hydrating agent, emollient, antioxidant, protectant, preservative, fragrance, and colorant.

9. A repairing face cream, characterized in that, The repair cream comprises, by weight percentage: allantoin 0.05%-0.3%, acetylated sodium hyaluronate 0.01%-0.1%, cetyl-PG hydroxyethyl palmitamide 0.1%-2%, anti-allergy agent 0.5%-5%, hydrosol 0.1%-5%, hydrogenated coconut oil glycerides 1%-2.5%, jojoba esters 1%-2.5%, lauroyl lysine 0.5%-3%, cetyl palmitate 0.5%-1.5%, cetearyl alcohol 1.75%-3.25%, stearyl alcohol polyether-21 0.8%-1.5%, glyceryl stearate 1.5%-2.5%, white beeswax 0.5%-2%; the remainder is water. The anti-allergy agent includes octyl dodecanol, plantago seed oil, sunflower seed oil unsaponifiables, *Hemerocallis fulva* flower / leaf / vine extract, and tocopherol; the hydrosol includes water, glycerin, sodium dihydrogen phosphate, disodium hydrogen phosphate, and soluble collagen.

10. The repairing face cream according to claim 9, characterized in that, The repair cream also includes excipients at a weight percentage of 20.4%-59.9%.

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