Liquid-dispensing multi-port manifold, collection device, in-situ cleaning and dispensing system, and method

Abstract

A liquid-dispensing multi-port manifold (50), a collection device (95), an in-situ cleaning and dispensing system (100), and a method. Each feeding device (1001) of the in-situ cleaning and dispensing system (100) comprises a feeding source (15) and a reversing valve (11), wherein the feeding source (15) of at least one feeding device (1001) is gas, the feeding source (15) of at least one feeding device (1001) is a cleaning liquid, and the feeding source (15) of at least one feeding device (1001) is a material to be dispensed; a plurality of feeding devices (1001) are connected in parallel to a cleaning multi-way valve bank (70) through cleaning piping (20), and are connected in parallel to a conveying multi-way valve (40) through conveying piping (30); and a dispensing apparatus (60) is drivingly connected to the conveying multi-way valve (40).

Description

Multi-channel separator, collection device, in-situ cleaning dispensing system and method

[0001] Related applications

[0002] This application claims priority to Chinese Patent Application No. 202510121069.8, filed on January 24, 2025, entitled "Multi-channel liquid dispensing head, collection device, in-situ cleaning and dispensing system and method", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of material dispensing, and in particular to a multi-channel dispensing head, a collection device, an in-situ cleaning dispensing system and method. Background Technology

[0004] It is very inconvenient to use different dispensing equipment when different reagents need to be dispensed. However, when switching between the same dispensing equipment, cross-contamination between pipelines is easy to occur, making it difficult to maintain cleanliness. Furthermore, contamination is also easy to occur at the valve inlet each time different reagents are switched. Overall, the dispensing safety, dispensing efficiency, and dispensing convenience are all low. Summary of the Invention

[0005] In view of this, it is necessary to provide a multi-channel liquid dispensing head, a collection device, an in-situ cleaning and dispensing system and method.

[0006] An in-situ cleaning and dispensing system includes a feeding device assembly, a cleaning pipeline assembly, a cleaning multi-way valve assembly, a conveying pipeline assembly, a conveying multi-way valve, and dispensing equipment. The feeding device assembly includes multiple feeding devices, each including a feeding source and a reversing valve. The feeding source for at least one feeding device is gas, the feeding source for at least one feeding device is cleaning fluid, and the feeding source for at least one feeding device is the material to be dispensed. The reversing valve has at least three ports, defined as an internal valve port, a cleaning valve port, and a feeding valve port. The internal valve port is connected to the material supply source; the cleaning valve port is connected to one of the valve ports of the cleaning multi-way valve group through one of the cleaning pipelines in the cleaning pipeline group; the material supply valve port is connected to one of the material inlets of the material conveying multi-way valve through one of the material conveying pipelines in the material conveying pipeline group; the material distribution device is driven and connected to the material outlet of the material conveying multi-way valve; the cleaning multi-way valve group, the material conveying multi-way valve, and each of the reversing valves can cooperate with each other to switch the provided material supply source and the flow path of the material supply source, thereby completing in-situ cleaning, in-situ feeding, and in-situ material distribution.

[0007] This application also provides a multi-channel liquid dispensing head, which includes a main channel and multiple branch channels, one end of each branch channel being connected to the same end of the main channel; the multiple branch channels are arranged circumferentially along the central axis of the main channel, and the central axis of each branch channel has an angle with the central axis of the main channel, the angle being a right angle or an acute angle.

[0008] This application also provides a collection device, including a storage component and a collection tube, the collection tube having an inlet and an outlet, the outlet being connected to the storage component, the object to be collected entering the collection tube from the inlet and entering the storage component through the outlet;

[0009] An anti-return structure is provided between the input port and the output port to prevent the material to be collected from entering the storage device from flowing back to the output port or evaporating.

[0010] This application also provides an initialization method for an in-situ cleaning and dispensing system, including the aforementioned in-situ cleaning and dispensing system, defining a gas-based feeding device as an air inlet device, a cleaning fluid-based feeding device as a liquid inlet device, and a material-to-be-dispensed feeding device as a feed inlet device; the method includes:

[0011] S0, pre-sterilize the liquid inlet device, the air inlet device and the feed inlet device;

[0012] S1, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and material conveying pipeline connected to the air inlet device.

[0013] S2, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, gas is provided and the gas flow path is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and / or material conveying pipeline connected to the air inlet device, and to dry the cleaning pipeline and / or material conveying pipeline connected to the air inlet device.

[0014] S3, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and conveying pipeline connected to the feeding device.

[0015] S4, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, gas is provided and the flow path of the gas is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and conveying pipeline connected to the feeding device, and to dry the cleaning pipeline and conveying pipeline connected to the feeding device.

[0016] This application provides a material distribution method for an in-situ cleaning and dispensing system, including the aforementioned in-situ cleaning and dispensing system. A gas-based feeding device is defined as an air inlet device; a cleaning fluid-based feeding device is defined as a liquid inlet device; and a material-to-be-dispensed feeding device is defined as a material-feeding device. The path formed by the material-feeding source of the liquid inlet device, the reversing valve, the cleaning pipeline, and the cleaning multi-way valve is defined as a first cleaning output branch; and the path formed by the material-feeding source of the liquid inlet device, the reversing valve, the conveying pipeline, and the conveying multi-way valve is defined as a second cleaning output branch. The method includes: defining the path formed by the reversing valve of the air intake device, the cleaning pipeline to the cleaning multi-way valve as the first gas branch; defining the path formed by the reversing valve of the air intake device, the conveying pipeline to the conveying multi-way valve as the second gas branch; defining the path formed by the reversing valve of the feeding device, the cleaning pipeline to the cleaning multi-way valve as the first material branch; defining the path formed by the reversing valve of the feeding device, the conveying pipeline to the conveying multi-way valve as the second material branch; defining the path formed by the conveying multi-way valve to the end of the distribution equipment as the main distribution path; the method includes:

[0017] Q1, Select the target material to be packaged, and based on the feeding device where the selected target material to be packaged is located, connect only the second material branch to the main material distribution road; start the material distribution equipment so that the target material to be packaged is output along the second material branch to the end of the main material distribution road to complete the packaging of the target material to be packaged;

[0018] F1, Select target cleaning fluid. Based on the feeding device where the selected target cleaning fluid is located, connect only the second cleaning output branch to the main distribution road; start the distribution equipment to output the target cleaning fluid along the second cleaning output branch to the end of the main distribution road, so as to complete the cleaning of the main distribution road;

[0019] F2, Select target gas, based on the gas inlet device where the selected target gas is located, connect only the second gas branch and the main distribution line; start the distribution equipment to output the target gas along the second gas branch to the end of the main distribution line, so as to complete the venting and drying of the main distribution line.

[0020] Details of one or more embodiments of this application are set forth in the following drawings and description. Other features, objects, and advantages of this application will become apparent from the specification, drawings, and claims. Attached Figure Description

[0021] To better describe and illustrate embodiments and / or examples of the inventions disclosed herein, reference may be made to one or more accompanying drawings. Additional details or examples used to describe the drawings should not be considered as limiting the scope of any of the disclosed inventions, the currently described embodiments and / or examples, or the best mode of these inventions as currently understood.

[0022] Figure 1 is a schematic diagram of the structure of an in-situ cleaning and material distribution system provided in an embodiment of this application.

[0023] Figure 2 is a schematic diagram of the material conveying multi-way valve structure provided in an embodiment of this application.

[0024] Figure 3 is a schematic diagram of the material conveying multi-way valve structure provided in another embodiment of this application.

[0025] Figure 4 is a three-dimensional structural diagram of an in-situ cleaning and material distribution system provided in an embodiment of this application.

[0026] Figure 5 is a cross-sectional view of a partial structure of an in-situ cleaning and dispensing system provided in an embodiment of this application.

[0027] Figure 6 is a schematic diagram of the initialization method of an in-situ cleaning and material distribution system provided in this application.

[0028] Figure 7 is a schematic diagram of the initialization method of an in-situ cleaning and material distribution system provided in this application.

[0029] Figure 8 is a schematic diagram of some steps of the initialization method of an in-situ cleaning and material distribution system provided in this application.

[0030] Figure 9 is a schematic diagram of some steps of the initialization method of an in-situ cleaning and material distribution system provided in this application.

[0031] Figure 10 is a schematic diagram of some steps of the initialization method of an in-situ cleaning and material distribution system provided in this application.

[0032] Figure 11 is a schematic diagram of the material distribution method of an in-situ cleaning material distribution system provided in this application.

[0033] Figure 12 is a schematic diagram of the material distribution method of an in-situ cleaning material distribution system provided in this application.

[0034] Figure 13 is a schematic diagram of the material distribution method of an in-situ cleaning and material distribution system provided in this application. 100, In-situ cleaning and material distribution system; 10, Material feeding device group; 1001, Material feeding device; 101, Liquid inlet device; 102, Air inlet device; 103, Material feeding device; 11, Reversing valve; 111, Internal valve port; 112, Cleaning valve port; 113, Material feeding valve port; 12, Check valve; 13, Filter; 14, Storage container; 141, Receptacle section; 142, Sealing section; 15, Material supply source; 20, Cleaning pipe. 21. Conveying Pipeline Assembly; 30. Conveying Pipeline Assembly; 31. Conveying Pipeline; 40. Conveying Multi-Way Valve; 41. Conveying Inlet; 42. Conveying Outlet; 43. Valve Core; 44. Main Body; 45. Conveying Branch Line; 46. Main Conveying Line; 50. Liquid Separating Multi-Way Head; 51. Branch Flow Channel; 511. Combination Section; 512. Connector Section; 513. Sealing End Face; 52. Main Flow Channel; 60. Distributing Equipment; 61. Liquid Separator Piping; 601, Dispensing Inlet; 602, Dispensing Outlet; 62, Transfer Pump; 63, Dispensing Connector; 90, Dispensing Nozzle; 70, Cleaning Multi-Way Valve Assembly; 71, T-Type Three-Way Valve; 701, Main Bypass Channel; 702, Branch Bypass Channel; 80, Outer Housing; 81, Lower Support Housing; 811, Clearance Opening; 82, Upper Protective Housing; 821, Circumferential Baffle; 822, Cover; 88, First Touchscreen; 91, Pipeline 911. Road handling component; 92. First liquid receiving component; 93. Drain pipe; 94. Second liquid receiving component; 95. Collection device; 951. Storage component; 952. Collection pipe; 953. Anti-reversion structure; 954. Gas filter component; 96. Host computer; 97. Second touch screen; 98. Circuit control board; 200. Initialization method of in-situ cleaning and dispensing system; 300. Dispensing method of in-situ cleaning and dispensing system. Detailed Implementation

[0035] The technical solutions in the embodiments of this application are described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0036] It should be noted that when a component is said to be "connected to" another component, it can be directly connected to the other component or it can be centered within another component. When a component is said to be "set to" another component, it can be directly set to the other component or it may also be centered within another component. When a component is said to be "fixed to" another component, it can be directly fixed to the other component or it may also be centered within another component.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the specification of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "or / and" as used herein includes any and all combinations of one or more of the associated listed items.

[0038] It is very inconvenient to use different dispensing equipment when different reagents need to be dispensed. However, when switching between the same dispensing equipment, cross-contamination between pipelines is easy to occur, making it difficult to maintain cleanliness. Furthermore, contamination is also easy to occur at the valve inlet each time different reagents are switched. Overall, the dispensing safety, dispensing efficiency, and dispensing convenience are all relatively low.

[0039] Based on this, this application provides an in-situ cleaning and dispensing system 100, which can clean the dispensing system structure in situ and switch between different materials for feeding and dispensing. It should be noted that cleaning includes, but is not limited to, one or more of washing, sterilization, evacuation, and drying. Furthermore, the in-situ cleaning and dispensing system 100 provided by this application is used in the field of material dispensing, including but not limited to the dispensing of materials such as biological reagents, chemical reagents, and food and beverages.

[0040] Referring to Figures 1 to 5, the in-situ cleaning and dispensing system 100 provided in this application includes a feeding device group 10, a cleaning pipeline group 20, a cleaning multi-way valve group 70, a conveying pipeline group 30, a conveying multi-way valve 40, and a dispensing device 60. The feeding device group 10 includes multiple feeding devices 1001, each feeding device 1001 including a feeding source 15 and a reversing valve 11. The feeding source 15 of at least one feeding device 1001 is gas, the feeding source 15 of at least one feeding device 1001 is cleaning fluid, and the feeding source 15 of at least one feeding device 1001 is the material to be dispensed. The reversing valve 11 has at least three valve ports, which are defined as an internal valve port 111, a cleaning valve port, etc. 112 and a feeding valve port; wherein, the internal valve port 111 is connected to the feeding source 15, and the cleaning valve port 112 is connected to one of the valve ports of the cleaning multi-way valve group 70 through a cleaning pipe 21 in the cleaning pipe group 20; the feeding valve port is connected to one of the feeding inlets 41 of the feeding multi-way valve 40 through a feeding pipe 31 in the feeding pipe group 30; the material distribution device 60 is driven and connected to the feeding outlet 42 of the feeding multi-way valve 40 to provide the driving force for pumping out the feeding source; the cleaning multi-way valve group 70, the feeding multi-way valve 40, and each reversing valve 11 can cooperate with each other to switch the provided feeding source 15 and the flow path of the feeding source 15 to complete in-situ cleaning, in-situ feeding, and in-situ distribution.

[0041] The in-situ cleaning and dispensing system 100 provided in this application can use cleaning fluid to clean any flow path and valve port in situ through the cooperation between pipelines and valves, and use gas to complete the drainage and drying of residual liquid, so as to keep each flow path in the dispensing system clean, effectively avoid cross-contamination problems after material storage, material access and material switching, and enable different materials to be dispensed to be quickly switched and dispensed under the same dispensing pipeline system, which greatly improves dispensing efficiency, dispensing convenience and dispensing safety.

[0042] Referring to Figures 1 and 4, in one embodiment, the reversing valve 11 is a three-way valve, that is, a three-position three-way valve. It is understood that in other embodiments, the reversing valve 11 may also be a four-way valve or other types of valve bodies, as long as it does not affect the functional realization of the in-situ cleaning and dispensing system 100.

[0043] Referring to Figures 1 and 4, in one embodiment, the cleaning multi-way valve assembly 70 includes multiple T-type three-way valves 71 arranged in series. Two parallel and opposite valve ports of the multiple T-type three-way valves 71 are sequentially connected to form a main bypass channel 701, and the other valve port of each T-type three-way valve 71 correspondingly forms multiple branch bypass channels 702. In other words, the multiple branch bypass channels 702 are connected in parallel to a main bypass channel 701, and each branch bypass channel 702 can be switched on and off with the combined main bypass channel 701. Essentially, the piping configuration of the cleaning multi-way valve assembly 70 consists of multiple T-shaped pipes and multiple multi-way valves connected in parallel, with a separate valve at each inlet and outlet controlling the on / off state of the main bypass channel 701 and the branch bypass channel 702. It can be understood that adjacent T-type three-way valves 71 are connected by connecting pipes.

[0044] Since the cleaning multi-way valve assembly 70 serves as an intermediate valve station connecting the cleaning pipelines 21 of each feeding device 1001 in the entire system, it is equivalent to a collection device for switching cleaning fluid and clean air. Simultaneously, during the initialization process of the in-situ cleaning and dispensing system, the cleaning multi-way valve assembly 70 also needs to be cleaned and sterilized with cleaning fluid. Therefore, the flow channels within the cleaning multi-way valve assembly 70 require a flow direction design to ensure that the cleaning fluid passes through without blind ends or dead zones. Similarly, after cleaning, a flow direction design is needed to ensure that clean air can completely drain the cleaning fluid from the cleaning pipeline 21 valve assembly, again without blind ends or dead zones. Therefore, when the cleaning multi-way valve assembly 70 is composed of multiple T-type three-way valves 71 connected in parallel, it is required that one end of the horizontal direction of the cleaning multi-way valve assembly 70 be used for supplying cleaning fluid (e.g., ethanol), and the other end be used for supplying gas (e.g., clean air), so that the cleaning fluid or gas can pass through all valve bodies, minimizing blind ends and dead zones.

[0045] Therefore, in one embodiment, a gas supply device 1001 and a cleaning fluid supply device 1001 are respectively connected horizontally to two valve ports at both ends of the main bypass channel 701 via their respective connected cleaning pipelines 21. In other words, when the cleaning multi-way valve group 70 is in the form of multiple parallel T-shaped structures, the T-shaped structures are required to be arranged in the forward direction so that at least one cleaning fluid is horizontally connected from one end, at least one gas is horizontally connected from the other end, and all materials to be distributed are connected from the lower end of the T-shaped structure. The cleaning fluid and gas can flow through the entire main bypass channel 701 and both sides of the main bypass channel 701, and can also flow out from each branch bypass channel 702 through the main bypass channel 701, effectively avoiding cleaning dead zones and blind ends.

[0046] It is understood that in other embodiments, the cleaning multi-way valve assembly 70 may also be composed of other forms of parallel and / or series pipelines and different valves. For example, in one embodiment, the cleaning multi-way valve assembly 70 is composed of a multi-inlet single-outlet multi-way switching valve and a single-inlet multi-outlet multi-way switching valve connected in series. In this case, the connection positions of the feeding device 1001 configured with gas as the feeding source 15 and the feeding device 1001 configured with cleaning fluid as the feeding source 15 are not limited.

[0047] Referring to Figures 1 and 4, in one embodiment, the gas supply device 1001, where the supply source 15 is configured as a gas, further includes a one-way valve 12 and a filter 13. The reversing valve 11 of the gas supply device 1001 is an inverted T-type three-way valve, wherein the inner valve port 111 faces upward and is sequentially connected to the one-way valve 12, the filter 13, and the supply source 15. That is, the installation position relationship of the three-way valve, the one-way valve 12, and the filter 13 of the gas supply device 1001 requires that the filter 13 is on the one-way valve 12, the one-way valve 12 is on the three-way valve, the three are installed vertically in series, and the three-way valve is installed in an inverted T-shape.

[0048] With this configuration, the inverted T-type three-way valve ensures that when the system is connected to the air inlet device 102 for air supply, the cleaning fluid can clean the inside of the three-way valve of the corresponding air supply device 1001 through the cleaning pipeline. At the same time, it ensures that when the one-way valve 12 is switched to open the air inlet, the cleaning fluid will not flow back into the air supply device 1001.

[0049] In one embodiment, the gas-based feeding device 1001 further includes a storage container connected to the side of the filter 13 away from the reversing valve 11, for storing the gas-based feeding source 15. In some embodiments, the gas can be clean air, which may not require a storage container and can be directly filtered by the filter 13 and introduced into the in-situ cleaning and dispensing system 100. However, when the gas is nitrogen, helium, high-temperature steam, or other gases, a storage container can be used for storage to facilitate retrieval and sterilization.

[0050] Referring to Figures 1 and 4, in one embodiment, the feeding device 1001, configured with a feeding source 15 as a cleaning liquid or material to be dispensed, further includes a storage container 14 and a filter 13. The storage container 14 has a first hole and a second hole, wherein the first hole is connected to the internal valve port 111 of the reversing valve 11, and the second hole is connected to the filter 13. That is, when the feeding source 15 is a liquid, a storage container 14 can be configured to store the feeding source 15, and an air inlet is required so that the feeding source 15 can be pumped out of the storage container 14 for dispensing or use. The filter 13 at the second hole can prevent the feeding source 15 in the storage container 14 from being contaminated by the external environment.

[0051] Furthermore, when the cleaning fluid or the material to be packaged has volatile properties, the supply source is prone to loss due to evaporation or pollution of the external environment after evaporation. Therefore, in some embodiments, the supply source 15 is configured as a feeding device 1001 for the cleaning fluid or the material to be packaged, which also includes a one-way valve 12. The second port is connected to the filter through the one-way valve 12 to reduce or avoid the risk of liquid loss or environmental pollution.

[0052] In one embodiment, the storage container 14 includes an accommodating portion 141 and a sealing portion 142 connected to each other, with a first hole and a second hole formed in the sealing portion 142; wherein the sealing portion 142, the one-way valve 12, the reversing valve 11, and the filter 13 are an integral structure. It is understood that the integral structure is convenient to use and facilitates overall sterilization and cleaning.

[0053] It is understood that gases include, but are not limited to, one or more of air, nitrogen, helium, and high-temperature steam. Cleaning solutions include, but are not limited to, one or more of bleach, acid or alkali solutions, organic solvents, alcohols, water, and high-temperature steam.

[0054] It is understandable that using a cleaning solution with bactericidal effects can simultaneously clean and sterilize pipelines. Using a volatile, residue-free cleaning solution facilitates rapid drying after cleaning. For example, using ethanol as the cleaning solution combines the advantages of sterilization and easy drying after cleaning.

[0055] Referring to Figures 1, 2, 4, and 5, in one embodiment, the material conveying multi-way valve 40 is a multi-inlet, single-outlet multi-way switching valve. Specifically, the material conveying multi-way valve 40 includes a main body 44 and a valve core 43 movably connected to the main body 44. The main body 44 is provided with multiple material conveying branches 45 and a main material conveying channel 46. By rotating the valve core 43, different material conveying branches 45 can be switched to connect with the main material conveying channel 46.

[0056] It is understood that the end of each conveying branch 45 away from the valve core 43 is the conveying inlet 41 of the conveying multi-way valve 40, and the end of the conveying main line 46 away from the valve core 43 is the conveying outlet 42 of the conveying multi-way valve 40. The material sources 15 of multiple feeding devices 1001 enter the conveying multi-way valve 40 from different conveying branches 45, and share the same conveying main line 46 to output to the outside of the conveying multi-way valve 40. Therefore, when switching the material to be packaged, at least the path from the output main line to the end of the material distribution equipment 60 needs to be cleaned.

[0057] Referring to Figure 3, it can be understood that in other embodiments, the multi-way conveying valve 40 can also be a multi-inlet and multi-outlet switching valve. That is, in other embodiments, the multi-way conveying valve 40 can have multiple conveying outlets 42. Thus, each conveying outlet 42 can be connected to a dispensing device 60 to increase the number of portions of material to be dispensed each time as needed.

[0058] It is understood that in some embodiments, the reversing valve and the cleaning multi-way valve group can also be implemented as multi-inlet single-outlet or multi-inlet multi-outlet multi-way switching valves as shown in Figures 2 and 3. In other words, as long as the functions of in-situ cleaning, in-situ feeding, and in-situ dispensing of the in-situ cleaning and dispensing system can be realized, the types and configurations of the reversing valve, the cleaning multi-way valve group, and the conveying multi-way valve are not limited in other embodiments.

[0059] Referring to Figures 1, 4, and 5, the in-situ cleaning and dispensing system 100 further includes a dispensing multi-port head 50, and the dispensing device 60 is connected to a conveying outlet 42 of the conveying multi-port valve 40 via the dispensing multi-port head 50. The dispensing multi-port head 50 facilitates the even distribution of the material to be dispensed from the conveying multi-port valve 40 to the dispensing device 60.

[0060] Referring to Figures 1, 4, and 5, the multi-channel dispensing head 50 includes a main flow channel 52 and multiple branch flow channels 51 connected to the same end of the main flow channel 52. One end of the main flow channel 52, away from the branch flow channels 51, is connected to the conveying outlet 42 of the conveying multi-way valve 40. The other ends of the multiple branch flow channels 51 are respectively connected to multiple dispensing inlets 601 of the dispensing device 60. The multiple branch flow channels 51 are symmetrically arranged circumferentially along the central axis of the main flow channel 52, and each branch flow channel 51 has an angle with the central axis of the main flow channel 52, which is either a right angle or an acute angle. This arrangement ensures equal resistance in each branch flow channel 51, facilitating uniform and stable dispensing.

[0061] Furthermore, the central axes of the multiple branch channels 51 intersect at the same point on the central axis of the main channel 52; and / or, the channel shapes of the multiple branch channels 51 are identical; and / or, the inner wall finish of the multiple branch channels 51 is identical; and / or, the channel lengths of the multiple branch channels 51 are equal; and / or, the inner diameters of the multiple branch channels 51 are equal. This further ensures that the resistance, flow velocity, and flow rate of each channel are equal, further reducing the risk of uneven flow rates in each branch channel 51. Moreover, the smooth inner walls and seamless structural transitions of the channels further prevent the formation of cleaning dead zones.

[0062] Referring to Figure 5, further, along the direction of gravity, the liquid distribution multi-port head 50 is installed above the material conveying multi-port valve 40. In other words, the main flow channel 52 of the liquid distribution multi-port head 50 is at the bottom, and the various branch flow channels 51 are evenly distributed and obliquely upward, so that the flow direction of the liquid in the liquid distribution multi-port head 50 is upward or obliquely upward. In this way, the inlet is located in the middle of the bottom, and the design of the branches being symmetrical and evenly distributed obliquely upward facilitates the smooth discharge of gas bubbles in the flow channel, avoids the accumulation of bubbles to form air chambers, and thus avoids the formation of air chambers that cause uneven flow.

[0063] Referring to Figure 5, further, in this embodiment, both the material inlet 41 and the material outlet 42 of the material conveying multi-way valve 40 face upwards. This facilitates the removal of air bubbles from the material conveying multi-way valve 40 and facilitates the connection of the pipeline to the material inlet 41.

[0064] For example, the included angle is defined as 'a', where 20° ≤ a ≤ 60°. This facilitates fluid flow and also helps to expel air bubbles from the flow channel.

[0065] Referring to Figures 4 and 5, in one embodiment, each branch channel 51 includes a coaxially arranged and interconnected confluence section 511 and a connector section 512. The end of the confluence section 511 facing away from the connector section 512 is connected to the main channel 52. The connector section 512 is used to connect to the material distribution device 60. The inner diameter of the connector section 512 is larger than the inner diameter of the confluence section 511, so as to form a sealing end face 513 at the junction of the connector section 512 and the confluence section 511. The sealing end face 513 is used to achieve a sealed connection with the material distribution device 60.

[0066] Referring to Figures 1, 4, and 5, the material distribution device 60 includes a conveying pump 62, a liquid distribution pipeline 61, and a liquid distribution connector 63. The conveying pump 62 has multiple dispensing inlets 601 and multiple dispensing outlets 602. The liquid distribution connector 63 has a first insertion end and a second insertion end facing away from each other. The first insertion end is inserted into the connector section 512, and the end face of the first insertion end abuts against the sealing end face 513. The second insertion end is connected to one of the dispensing inlets 601 through the liquid distribution pipeline 61. It should be noted that the sealing end face 513 is an annular stepped surface, and the first insertion end has the same diameter as the sealing end face 513.

[0067] Referring to Figure 5, furthermore, the liquid distribution connector 63 is threadedly connected to the liquid distribution multi-port head 50. Specifically, the first insertion end has an external thread, and the connector section 512 has an internal thread; the first insertion end is threadedly connected to the connector section 512. This threaded connection ensures reliable connection, and the connection between the liquid distribution connector 63 and the liquid distribution multi-port head 50 uses an equal-diameter end-to-end sealing method, which facilitates the elimination of fluid dead zones and allows for more thorough cleaning of the flow channel.

[0068] In one embodiment, the dispensing device 60 further includes a dispensing nozzle 90, which is installed at the dispensing outlet 602 or connected to the dispensing outlet 602 via a dispensing pipe. It is understood that when the dispensing nozzle 90 is installed, it forms the end of the dispensing device 60.

[0069] Referring to Figures 4 and 5, in one embodiment, the in-situ cleaning and dispensing system 100 further includes a housing 80, within which at least a material conveying multi-way valve 40 and a liquid dispensing multi-way head 50 are installed. At least a portion of the housing 80 is transparent, allowing observation of the pipes connected to the material conveying multi-way valve 40 and the liquid dispensing multi-way head 50. This facilitates observation of each pipe, the surrounding area, and the fluid flow within the pipes, enabling timely detection of any abnormalities.

[0070] Referring to Figures 4 and 5, in one embodiment, the outer shell 80 includes a lower support shell 81 and an upper protective shell 82 connected to each other, the upper protective shell 82 being a transparent shell.

[0071] Furthermore, the lower support shell 81 includes multiple panels, which are joined together in a snap-fit ​​manner. This prevents external liquids from entering the shell and causing malfunctions. Additionally, the cable interface of the dispensing device 60 is designed to be waterproof or shielded to protect against liquid splashes in laboratory environments.

[0072] Referring to Figures 4 and 5, it should be noted that at least the feed inlet 41 of the multi-way valve 40 needs to be located inside the upper protective housing 82. This is to facilitate observation of the pipeline connections and the flow of fluid within the pipeline.

[0073] The upper protective shell 82 includes a circumferential baffle 821 and a cover 822. The cover 822 covers the top of the circumferential baffle 821 and circumferentially blocks part of the side wall of the circumferential baffle 821.

[0074] Referring to Figures 4 and 5, in one embodiment, the in-situ cleaning and distributing device further includes at least one pipe organizing component 91, which is mounted on the housing 80. At least one side of the pipe organizing component 91 has multiple receiving slots 911 for accommodating pipe bodies. With this configuration, the cleaning pipe, the conveying pipe 31, and the distributing pipe can all be secured by the pipe organizing component 91. The pipe organizing component 91 provides support and organization for the pipes, enhancing the stability of the pipe installation and facilitating clearer differentiation and observation of the status of each pipe.

[0075] Referring to Figures 4 and 5, in one embodiment, the pipe arrangement component 91 is detachably mounted to the housing 80. Thus, after the pipe arrangement component 91 is removed from the housing 80, it is easier to arrange or remove the pipes requiring arrangement.

[0076] In one embodiment, the pipe organizer 91 has a mounting groove on at least one side, and the pipe organizer 91 is engaged with the top edge of the circumferential baffle 821 through the mounting groove, and is located between the cover 822 and the circumferential baffle 821. This facilitates centralized observation of the connection status of each pipe and the fluid flow status within each pipe.

[0077] It is understood that in other embodiments, the pipe organizer 91 may also be fixed to the housing 80 in other ways. For example, a mounting protrusion may be provided on at least one side of the pipe organizer 91, and a snap-fit ​​hole may be provided on the protective housing. The pipe organizer 91 may be installed on the protective housing by the snap-fit ​​engagement of the mounting protrusion and the snap-fit ​​hole. It is understood that in other embodiments, the pipe organizer 91 may also be adhesively bonded to the housing 80.

[0078] Referring to Figures 4 and 5, the in-situ cleaning and dispensing system 100 also includes a circuit control board 98 and a first touch screen 88 installed on the housing 80. The circuit control board 98 is electrically connected to the material conveying multi-way valve 40 and the first touch screen 88. Thus, the flow channel in the material conveying multi-way valve 40 can be controlled independently via the first touch screen 88.

[0079] Furthermore, the in-situ cleaning and material distribution system 100 also includes a host computer 96 and a second touch screen 97. The host computer 96 is electrically connected to at least the second touch screen 97, the multi-way conveying valve 40, the material distribution device 60, and the circuit control board 98, and is used to control the opening and closing of each valve port and the start and stop of the material distribution device. It can be understood that the cleaning multi-way valve group 70 and the reversing valve 11 can be electric valves or manual valves. When the cleaning multi-way valve group 70 and the reversing valve 11 are electric valves, they can also be electrically connected to the host computer 96 for unified control.

[0080] Referring to Figures 4 and 5, in one embodiment, the in-situ cleaning and dispensing system 100 further includes a first liquid receiving element 92, which surrounds the periphery of the material conveying multi-way valve 40 and the liquid dispensing multi-way head 50, and is located below the material conveying inlet 41 of the material conveying multi-way valve 40.

[0081] Furthermore, the first liquid receiving component 92 can be configured as an annular liquid collecting groove opened on the top of the lower support shell 81, or it can be configured as an annular liquid collecting plate independently installed on the top of the lower support shell 81.

[0082] Referring to Figures 4 and 5, the in-situ cleaning and dispensing system 100 further includes a drain pipe 93, which is connected to the first liquid receiving element 92 and is used to discharge the liquid collected by the first liquid receiving element 92.

[0083] In other words, a liquid collection structure is provided at the bottom of the material inlet 41 and material outlet 42 of the material conveying multi-way valve 40 and around the liquid distribution multi-way head 50. This structure is used to collect waste liquid from sources such as leakage and condensation. The liquid collection structure is connected to a drain pipe 93, which can discharge the waste liquid in the liquid collection structure to prevent it from entering the machine body.

[0084] The dispensing device 60 also includes a second liquid receiving component 94, which is located below the end of the dispensing device 60. Specifically, it may be located below the dispensing outlet 602 and / or the dispensing nozzle, and is used to collect waste liquid that may seep out from the end of the dispensing device 60.

[0085] In one embodiment, the first liquid receiving element 92 is connected to the second liquid receiving element 94 via a drain pipe 93, meaning that the waste liquid from the first liquid receiving element 92 can be collected in the second liquid receiving element 94 and then discharged through the second liquid receiving element 94.

[0086] Referring to Figures 1, 4, and 5, in one embodiment, the in-situ cleaning and material distribution system 100 further includes a collection device 95, which includes a storage component 951 and a collection pipe 952. The collection pipe 952 has an inlet and an outlet. The outlet is connected to the storage component 951, and the inlet is connected to a first liquid receiving component 92 and / or a second liquid receiving component 94. Waste liquid enters the collection pipe 952 from the inlet and enters the storage component 951 through the outlet.

[0087] Referring to Figures 1, 4 and 5, the collection device 95 further includes an anti-backflow structure 953, which is located between the inlet and the outlet. The anti-backflow structure 953 is used to prevent waste liquid entering the storage unit 951 from flowing back to the outlet.

[0088] In one embodiment, the anti-reversion structure 953 is configured as a portion of the collection tube 952, with the portion of the tube U-shaped into a liquid-sealed buffer chamber into which the barrier liquid can be injected. It is understood that the barrier liquid can be provided via a supply source 15 of one of the feeding devices 1001.

[0089] Referring to Figure 1, it can be understood that the anti-backflow structure 953 can also be configured as a one-way valve 12 or a float valve, as long as it can prevent waste liquid backflow.

[0090] Referring to Figures 1, 4, and 5, the storage unit 951 is further provided with an exhaust port, and a gas filter 954 is installed at the exhaust port. The gas filter 954 is used to filter the gases volatilized from the waste liquid, thus avoiding the risk of the waste liquid polluting the air.

[0091] In one embodiment, the gas filter 954 includes an activated carbon filter 13. It is understood that in other embodiments, the type of gas filter 954 can be selected as needed, and it can also be a high-efficiency filter 13, which can be used for toxic substances or for filtering bacteria, spores, and other microorganisms.

[0092] Storage component 951 includes an interconnected container bottle and a container cap, with an exhaust port located on the container cap; gas filter 954 is an integral structure with the container cap. This facilitates use and overall cleaning and sterilization.

[0093] Referring to Figure 1, taking the example of a feeding device group 10 having 10 feeding devices 1001, the specific structure of the in-situ cleaning and distributing system 100 in one embodiment is described in detail.

[0094] Referring to Figure 1, for ease of understanding, the feeding device 1001 with gas as the material source 15 is defined as the air inlet device 102, the feeding device 1001 with cleaning liquid as the material source 15 is defined as the liquid inlet device 101, and the remaining feeding devices 1001 with the material to be packaged as the material source 15 are all defined as feeding devices 103. Among them, the air inlet device 102 is numbered ⑩, the liquid inlet device 101 is numbered ⑨, and the remaining 8 feeding devices 1001 are numbered ①-⑧ respectively.

[0095] The cleaning multi-way valve assembly 70 includes eight T-type three-way valves 71 arranged in a forward direction and connected sequentially. The eight lower valve ports of the eight T-type three-way valves 71 form eight branch bypass channels 702, which are respectively connected to the cleaning valve ports 112 of eight feeding devices 1001 through eight cleaning pipelines 21. The parallel valve ports of the eight T-type three-way valves 71 are connected sequentially to form a main bypass channel 701. The valve ports of two T-type three-way valves 71 located on both sides, facing away from each other, are respectively connected to the cleaning valve ports 112 of the liquid inlet device 101 and the air inlet device 102 through two cleaning pipelines 21. Referring to Figure 1, the eight T-type three-way valves 71 of the cleaning multi-way valve assembly 70 are numbered V1-V8. Along the main bypass channel 701, the valve port of V8 away from V1 is connected to the cleaning valve port 112 of the liquid inlet device 101⑨ through the cleaning pipeline 21, the valve port of V1 away from V8 is connected to the cleaning valve port 112 of the air inlet device 102⑩ through the cleaning pipeline 21, and the lower valve ports of V1 to V8 are connected to the cleaning valve ports of the feeding devices 103①-103⑧ in sequence through a cleaning pipeline.

[0096] Furthermore, the in-situ cleaning and distributing system 100 includes a multi-way valve 40 with 10 material inlets 41 and 1 material outlet 42. The feeding valve ports of the 10 feeding devices 1001 are connected to the 10 material inlets 41 through 10 material pipelines 31. The material outlet 42 is connected to the distributing equipment 60 through a liquid distributing multi-way head 50. The liquid distributing multi-way head 50 has one main flow channel 52 and eight branch flow channels 51, that is, it has one liquid distributing inlet and eight liquid distributing outlets. The liquid distributing inlet is connected to the material outlet 42. The eight liquid distributing outlets are connected to the eight liquid distributing inlets of the distributing equipment 60 through eight liquid distributing pipelines 61. The eight liquid distributing outlets of the distributing equipment 60 are connected to the eight liquid distributing nozzles 90 through eight liquid distributing pipelines 61.

[0097] Referring to Figure 1, the material distribution device 60 is further provided with a second liquid receiving component 94, the inlet of the collection pipe 952 of the collection device 95 is connected to the second liquid receiving component 94, and the anti-reverse structure 953 is configured as a one-way valve 12 located between the inlet and outlet of the collection pipe 952.

[0098] Furthermore, the cleaning solution in the liquid inlet device 101⑨ is configured as ethanol, and the gas in the air inlet device 102⑩ is configured as air. It should be noted that the air entering the in-situ cleaning and dispensing system 100 is clean air; specifically, it can be directly introduced clean air, or it can be natural air filtered through the filter 13 of the air inlet device 102. The materials to be dispensed in the feeding devices 103①-⑧ are different biological reagents. In this embodiment, the cleaning solution is specifically a 75% ethanol solution. It is understood that in other embodiments, the concentration of ethanol is not limited.

[0099] It should be noted that before the in-situ cleaning and dispensing device is used for dispensing, an initialization process needs to be completed to avoid contamination of the dispensed biological reagents. Initialization involves using ethanol from the liquid inlet device 101⑨ to clean and sterilize all flow paths and valves within the entire in-situ cleaning and dispensing system 100, and using clean gas from the air inlet device 102 to drain and dry any residual ethanol from the cleaned and sterilized flow paths and valves. After initialization, the flow paths required for dispensing the target biological reagents can be connected through the coordination of the cleaning multi-port valve group 70, the dispensing multi-port valve 40, and each directional valve 11. The dispensing pump of the dispensing device 60 can then be started in the forward direction, dispensing once or multiple times as needed.

[0100] It should be noted that when the next target biological reagent being dispensed differs from the previously dispensed biological reagent, the flow path from the multi-way valve 40 to the end of the dispensing equipment 60 needs to be cleaned, sterilized, and then emptied and dried using ethanol and clean air. Understandably, the cleaning, sterilization, and drying processes can be repeated as needed to ensure thorough cleaning.

[0101] Furthermore, it should be noted that the dispensing pump of the dispensing device 60 can also be started in reverse when there is a need for liquid recovery. For example, when biological reagents are rare and expensive, the dispensing pump can be started in reverse after dispensing to allow residual biological reagents in the corresponding flow path to flow back to the storage container 14 of the original feeding device 1001. This reduces losses and saves costs.

[0102] Furthermore, it can be understood that multiple cleaning solutions and gases can be used. For example, the feed source 15 in the feeding device 9 can be configured as ethanol, and the feed source 15 in the feeding device 8 can be configured as distilled water. After the pipeline is cleaned and sterilized using ethanol in the feeding device 9, it can be cleaned again using distilled water in the feeding device 8. Then, clean air is used to vent and dry the residual liquid in the flow path. In other words, the cleaning strategy and venting strategy can be designed according to the cleaning difficulty and requirements of different reagents. When the reagent is difficult to clean, it can be repeatedly switched between cleaning with cleaning solution and venting with gas to achieve the purpose of cleaning thoroughly.

[0103] In summary, the in-situ cleaning and material distribution system 100 provided in this application, wherein the cleaning multi-way valve group 70 and the material conveying multi-way valve 40 serve as two intermediate valve stations in conjunction with the reversing valves 11 of each material supply device 1001, can open and close the flow of any flow path and switch the output of any material supply source 15 as needed, thereby completing the in-situ cleaning, in-situ material supply and in-situ material distribution process, effectively solving the problem of cross-contamination during material storage, material access and material switching, and greatly improving the efficiency, convenience and safety of material distribution.

[0104] Referring to Figure 5, this application also provides a multi-channel dispensing head 50, which includes a main flow channel 52 and multiple branch flow channels 51. One end of each branch flow channel 51 is connected to the same end of the main flow channel 52. The multiple branch flow channels 51 are symmetrically arranged circumferentially along the central axis of the main flow channel 52, and the central axis of each branch flow channel 51 forms an angle with the central axis of the main flow channel 52, which is a right angle or an acute angle. This arrangement ensures that each branch flow channel 51 has equal resistance, facilitating uniform and stable dispensing.

[0105] Furthermore, the central axes of the multiple branch channels 51 intersect at the same point on the central axis of the main channel 52; and / or, the channel shapes of the multiple branch channels 51 are identical; and / or, the inner wall finish of the multiple branch channels 51 is identical; and / or, the channel lengths of the multiple branch channels 51 are equal; and / or, the inner diameters of the multiple branch channels 51 are equal. This further ensures that the resistance, flow velocity, and flow rate of each channel are equal, further reducing the risk of uneven flow rates in each branch channel 51. Moreover, the smooth inner walls and seamless structural transitions of the channels further prevent the formation of cleaning dead zones.

[0106] For example, the included angle is defined as 'a', where 20° ≤ a ≤ 60°. This facilitates fluid flow while also allowing air bubbles to escape from the flow channel.

[0107] In one embodiment, each branch channel 51 includes a coaxially arranged and interconnected confluence section 511 and a connector section 512. The end of the confluence section 511 facing away from the connector section 512 is connected to the main channel 52. The connector section 512 is used to connect to the dispensing device 60. The inner diameter of the connector section 512 is larger than the inner diameter of the confluence section 511, so as to form a sealing end face 513 at the junction of the connector section 512 and the confluence section 511. The sealing end face 513 is used for sealing connection with external components. In this way, the external components can achieve an equal diameter end-to-end seal with the dispensing multi-port head 50 through the sealing end face 513, which is beneficial to achieve no fluid dead zone and avoid liquid accumulation and incomplete cleaning.

[0108] Referring to Figure 5, the connector section 512 is further provided with internal threads. Thus, the connector section 512 can be threadedly connected to external components, increasing connection and sealing reliability. Furthermore, the multi-channel connector 50 can be made of, but is not limited to, PTFE, PEEK, nylon, polypropylene, or 316L stainless steel.

[0109] Referring to Figure 1 or Figure 4, this application also provides a collection device 95, including a storage component 951 and a collection tube 952. The collection tube 952 has an inlet and an outlet, with the outlet connected to the storage component 951. The object to be collected enters the collection tube 952 from the inlet and enters the storage component 951 through the outlet. An anti-reverse structure 953 is also provided between the inlet and the outlet to prevent the object to be collected from flowing back into the storage component 951 to the outlet.

[0110] In one embodiment, the anti-backflow structure 953 is configured as a portion of the collection tube 952, and the portion of the tube is U-shaped to form a liquid-sealed buffer chamber into which a barrier liquid can be injected. Thus, when the collected material is a gas or a volatile liquid, backflow loss and contamination problems can be effectively avoided.

[0111] Furthermore, the collection device 95 is also equipped with a sealing structure, which is located between the inlet and the liquid-sealed buffer chamber and is used to inject barrier liquid into the sealing buffer chamber.

[0112] In one embodiment, the anti-reverse structure 953 is configured as a check valve or a float valve. It is understood that in other embodiments, the anti-reverse structure 953 may also be configured as other types of valve bodies capable of providing a blocking function.

[0113] In one embodiment, the storage device 951 is provided with an exhaust port, and a gas filter 954 is provided at the exhaust port.

[0114] In one embodiment, the gas filter 954 includes an activated carbon filter 13.

[0115] In one embodiment, the storage component 951 includes a container bottle and a container cap connected to each other, with an exhaust port located on the container cap; the gas filter 954 is an integral structure with the container cap.

[0116] Furthermore, the storage component 951, the one-way valve 12, and the filter are all high-temperature resistant components, and the specific materials include, but are not limited to, PTFE, PEEK, and 316L stainless steel.

[0117] Referring to Figure 6, this application also provides an initialization method 200 for an in-situ cleaning and dispensing system, including the above-mentioned in-situ cleaning and dispensing system, defining the feeding device for the feeding source 15 as a gas as an air inlet device 102, defining the feeding device for the feeding source 15 as a cleaning liquid as a liquid inlet device 101, and defining the feeding device for the feeding source 15 as a material to be dispensed as a feeding device 103; the method includes steps S0, S1, S2, S3 and S4.

[0118] S0, pre-sterilize the liquid inlet device 101, the air inlet device 102 and the feed device 103.

[0119] S1, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the liquid inlet device 101 performs initial cleaning on the cleaning pipeline 21 and the material conveying pipeline 31 connected to the air inlet device 102.

[0120] S2, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, provides gas and switches the gas flow path, uses the gas of the air intake device 102 to vent the cleaning liquid in the cleaning pipeline 21 and / or the material conveying pipeline 31 connected to the air intake device 102, and dries the cleaning pipeline 21 and / or the material conveying pipeline 31 connected to the air intake device 102.

[0121] S3, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the liquid inlet device 101 performs initial cleaning on the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103.

[0122] S4, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, gas is provided and the flow path of the gas is switched. The cleaning liquid in the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103 is emptied by the gas of the air intake device 102, and the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103 are dried.

[0123] It should be noted that the cleaning multi-way valve group 70 and the material conveying multi-way valve 40 have also completed the initial cleaning, evacuation and drying processes in each cleaning pipeline and material conveying pipeline, and are all clean devices.

[0124] Furthermore, it can be understood that steps such as cleaning with cleaning fluid, draining the cleaning fluid, and drying pipelines can be repeated depending on the cleaning difficulty and requirements until the cleanliness requirement is met. It is important to emphasize that cleanliness can include sterility measurement parameters.

[0125] Referring to Figure 7, in some embodiments, the initialization method further includes steps S5 and S6 after step S2 or step S4.

[0126] S5, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the inlet device 101 performs initial cleaning on the conveying pipeline 31 and / or cleaning pipeline 21 connected to the inlet device 101.

[0127] S6, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, gas is provided and the gas flow path is switched. The gas of the air inlet device 102 is used to vent the cleaning liquid in the material conveying pipeline 31 and the cleaning pipeline 21 connected to the liquid inlet device 101, and to dry the cleaning pipeline 21 and the material conveying pipeline 31 connected to the liquid inlet device 101.

[0128] Referring to Figure 8, in one embodiment, the path formed by the feed source 15, reversing valve 11, cleaning pipeline 21, and cleaning multi-way valve of the liquid inlet device 101 is defined as the first cleaning output branch; the path formed by the feed source 15, reversing valve 11, and conveying pipeline 31 of the liquid inlet device 101 to the conveying multi-way valve 40 is defined as the second cleaning output branch; the path formed by the reversing valve 11, cleaning pipeline 21, and cleaning multi-way valve of the air inlet device 102 is defined as the first gas branch. The path formed by the reversing valve 11 of the air intake device 102, the conveying pipeline 31 to the conveying multi-way valve 40 is defined as the second gas branch; the path formed by the reversing valve 11 of the feed device 103, the cleaning pipeline 21 to the cleaning multi-way valve is defined as the first material branch; the path formed by the reversing valve 11 of the feed device 103, the conveying pipeline 31 to the conveying multi-way valve 40 is defined as the second material branch; the path formed by the conveying multi-way valve 40 to the end of the material distribution device 60 is defined as the main material distribution path.

[0129] S1 includes step S11. In S11, the first cleaning output branch, the first gas branch, the second gas branch, and the main material distribution line are connected through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline 21 and the material conveying pipeline 31 connected to the air inlet device 102, and the material distribution equipment 60 is shut down.

[0130] S2 includes step S21. In S21, the second gas branch and the main material distribution line are connected by the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11; the material distribution equipment 60 is started so that the gas in the air inlet device 102 is output to the end of the main material distribution line along the second gas branch, so as to use the gas in the air inlet device 102 to vent the cleaning liquid in the material conveying pipeline 31 connected to the air inlet device 102 and to dry the material conveying pipeline 31 connected to the air inlet device 102; and the material distribution equipment 60 is shut down.

[0131] Referring to Figure 9, in one embodiment, S3 includes step S31. In S31, the first cleaning output branch, the first material branch, the second material branch, and the main material distribution line are connected through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and the material distribution equipment 60 is shut down.

[0132] S4 includes step S41. In S41, the first gas branch, the first material branch, and the second material branch are connected to the main distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the distribution equipment 60 is started, so that the gas from the air intake device 102 is output along the first gas branch to the end of the main distribution line, so as to use the gas from the air intake device 102 to vent the cleaning liquid in the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and to dry the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and then the distribution equipment 60 is shut down.

[0133] Referring to Figure 10, in one embodiment, S5 includes step S51. In S51, the second cleaning output branch is connected to the main material distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the second cleaning output branch to the end of the main material distribution line, so that the cleaning liquid of the liquid inlet device 101 performs initial cleaning on the material conveying pipeline 31 connected to the liquid inlet device 101;

[0134] S6 includes step S61. In S61, the first gas branch, the first cleaning output branch, and the second cleaning output branch are connected to the main material distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the material distribution equipment 60 is started, and the cleaning liquid in the material conveying pipeline 31 and the cleaning pipeline 21 connected to the liquid inlet device 101 is emptied by the gas of the air inlet device 102, and the cleaning pipeline 21 and the material conveying pipeline 31 connected to the liquid inlet device 101 are dried.

[0135] It should be noted that when the flow path of a certain path is connected by the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, it means that all other flow paths are blocked, and gas or cleaning fluid can only flow in that path.

[0136] It should be further noted that each step can be repeated as needed; in other words, multiple cleaning, multiple evacuation, and multiple drying operations are possible. Specific cleaning, evacuation, and drying strategies can be designed and implemented based on the difficulty of cleaning the reagents and the degree of contamination in the tubing. These will not be listed here.

[0137] Furthermore, in one embodiment, the feeding device configured with gas as the material source 15 further includes a one-way valve 12 and a filter 13. The reversing valve 11 of the feeding device configured with gas as the material source 15 is a three-way valve arranged in an inverted T shape, wherein the inner valve port 111 faces upward and is sequentially connected to the one-way valve 12, the filter 13, and the material source 15. The feeding device configured with cleaning liquid or material to be dispensed as the material source 15 further includes a storage container 14, a one-way valve 12, and a filter 13. The storage container 14 has a first hole and a second hole, wherein the first hole is connected to the inner valve port 111 of the reversing valve 11, and the second hole is sequentially connected to the one-way valve 12 and the filter 13. Step S0 includes steps S00, S01, and S02.

[0138] S00, the three-way valve, storage container, check valve 12, and filter 13 of the liquid inlet device 101 are subjected to high-pressure and high-temperature sterilization, and the feed source 15 configured as cleaning solution is loaded into the sterilized storage container in an aseptic environment to obtain a pre-sterilized liquid inlet device 101; or, the three-way valve, storage container containing cleaning solution, check valve 12, and filter 13 of the liquid inlet device 101 are subjected to high-pressure and high-temperature sterilization to obtain a pre-sterilized liquid inlet device 101.

[0139] S01, the three-way valve, one-way valve 12, and filter 13 of the air intake device 102 are subjected to high-pressure and high-temperature sterilization, and connected to an air supply source configured as clean gas to obtain a pre-sterilized air intake device 102; or, the air intake device 102 further includes a storage container connected to the side of the filter 13 away from the three-way valve, for storing the material supply source 15; the three-way valve, the storage container containing the material to be dispensed, the one-way valve 12, and the filter 13 of the air intake device 102 are subjected to high-pressure and high-temperature sterilization to obtain a pre-sterilized air intake device 102.

[0140] S02, the three-way valve, storage container, check valve 12, and filter 13 of the feeding device 103 are subjected to high-pressure and high-temperature sterilization, and the material to be packaged is loaded into the sterilized storage container in an aseptic environment to complete the pre-sterilization of the feeding device 103; or, the three-way valve, the storage container containing the material to be packaged, the check valve 12, and the filter 13 of the feeding device 103 are subjected to high-pressure and high-temperature sterilization to obtain the pre-sterilized feeding device 103.

[0141] It should be noted that steps S00, S01, and S02 can be performed together or separately.

[0142] In one embodiment, S0 includes steps S03 and S04.

[0143] S03, put the liquid inlet device 101, the air inlet device 102 and the feed device 103 into the autoclave for sterilization.

[0144] S04, the cleaning solution is loaded into the sterilized liquid inlet device 101 and storage container 14 under aseptic conditions; the material to be dispensed is loaded into the sterilized feeding device 103 and storage container 14 under aseptic conditions.

[0145] Furthermore, in one embodiment, the reversing valve 11 is a three-way valve; the cleaning multi-way valve group 70 includes multiple T-type three-way valves 71 arranged in series, with two parallel and opposite valve ports of the multiple T-type three-way valves 71 connected sequentially to form a main bypass channel 701, and the other valve ports of the multiple T-type three-way valves 71 correspondingly forming multiple branch bypass channels 702; wherein, a material supply source 15 is configured as a gas supply device and a material supply source 15 is configured as a cleaning liquid supply device, which are respectively connected horizontally from both sides to the two valve ports at both ends of the main bypass channel 701 through the cleaning pipeline 21. S11 includes steps S111, S112, S113, S114, S115, S116, S117 and S118.

[0146] S111, connecting the material conveying pipeline 31 and the cleaning pipeline 21 corresponding to the liquid inlet device 101, and connecting the material conveying pipeline 31 and the cleaning pipeline 21 corresponding to the air inlet device 102.

[0147] S112, the cleaning pipelines 21 connected to the liquid inlet device 101 and the air inlet device 102 are respectively connected to the valve ports of the cleaning multi-way valve group 70.

[0148] S113, the material conveying pipelines 31 corresponding to the liquid inlet device 101 and the air inlet device 102 are respectively connected to the two material conveying inlets 41 of the material conveying multi-way valve 40.

[0149] S114, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 with the internal valve port 111.

[0150] S115, switch the three-way valve of the air intake device 102 to connect the cleaning valve port 112 and the feeding valve port 113.

[0151] S116, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the liquid inlet device 101 and the air inlet device 102.

[0152] S117, switch the material conveying multi-way valve 40 to connect with the material conveying pipeline 31 corresponding to the air intake device 102.

[0153] S118, start the material distribution equipment 60, so that the cleaning liquid passes through the three-way valve of the liquid inlet device 101, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the air inlet device 102, the three-way valve of the air inlet device 102, the material conveying pipeline 31 corresponding to the air inlet device 102, and the material conveying multi-way valve 40 to the end of the material distribution equipment 60, thereby completing the cleaning and sterilization of the cleaning pipeline and the material conveying pipeline 31 connected to the air inlet device 102.

[0154] In one embodiment, S21 includes steps S211, S212 and S213.

[0155] S211, switch the three-way valve of the air intake device 102 to connect the inner valve port 111 with the feed valve port 113.

[0156] S212, start the material distribution device 60, so that the gas passes through the three-way valve of the air inlet device 102, the corresponding material conveying pipeline 31 of the air inlet device 102, the material conveying multi-way valve 40 and the end of the material distribution device 60, to complete the discharge of cleaning liquid residue and pipeline drying.

[0157] S213, shut down the material distribution equipment 60, and complete the initialization process of the cleaning pipeline and material conveying pipeline 31 connected to the air intake device 102.

[0158] In one embodiment, S31 includes steps S311, S312, S313, S314, S315, S316, S317 and S318.

[0159] S311, connecting the feed pipe 31 and cleaning pipe 21 corresponding to the liquid inlet device 101, and connecting the feed pipe 31 and cleaning pipe 21 corresponding to the feed device 103.

[0160] S312, connect the cleaning pipelines 21 that are connected to the liquid inlet device 101 and the feed device 103 respectively to the valve ports connected to the cleaning multi-way valve group 70.

[0161] S313, the conveying pipelines 31 corresponding to the liquid inlet device 101 and the feed device 103 are respectively connected to the two feed inlets 41 of the conveying multi-way valve 40.

[0162] S314, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 with the internal valve port 111.

[0163] S315, switch the three-way valve of the feeding device 103 to connect the cleaning valve port 112 and the feeding valve port 113.

[0164] S316, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the liquid inlet device 101 and the feed device 103.

[0165] S317, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the feed device 103.

[0166] S318, start the dispensing equipment 60, so that the cleaning fluid passes through the three-way valve of the liquid inlet device 101, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the feeding device 103, the three-way valve of the feeding device 103, the conveying pipeline 31 corresponding to the feeding device 103, and the conveying multi-way valve 40 to the end of the dispensing equipment 60, thereby completing the cleaning and sterilization of the cleaning pipeline and the conveying pipeline 31 connected to the feeding device 103.

[0167] In one embodiment, S41 includes steps S411, S412, S413, S414 and S415.

[0168] S411, switch the three-way valve of the intake device 102 to connect the inner valve port 111 with the cleaning valve port 112.

[0169] S412, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the air intake device 102 and the feeding device 103.

[0170] S413, switch the three-way valve of the feeding device 103 to connect the cleaning valve port 112 and the feeding valve port 113.

[0171] S414, switch the material conveying multi-way valve 40 to connect with the material conveying pipeline 31 corresponding to the feeding device 103.

[0172] S415, start the material distribution equipment 60, so that the gas passes through the three-way valve of the air inlet device 102, the cleaning pipeline corresponding to the air inlet device 102, the main bypass channel 701 of the cleaning multi-way valve group 70, the branch bypass channel 702 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the feeding device 103, the three-way valve of the feeding device 103, the conveying pipeline 31 corresponding to the feeding device 103, and the conveying multi-way valve 40 to the end of the material distribution equipment 60, so as to complete the discharge of residual cleaning liquid and the drying of pipeline.

[0173] S415, shut down the material distribution equipment 60, and complete the initialization process of the cleaning pipeline and conveying pipeline 31 connected to the feeding device 103.

[0174] In one embodiment, S51 includes steps S511, S512 and S513.

[0175] S511, switch the three-way valve of the liquid inlet device 101 to connect the inner valve port 111 with the feed valve port 113.

[0176] S512, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the liquid inlet device 101.

[0177] S513, start the material distribution equipment 60 to complete the cleaning and sterilization of the material conveying pipeline 31 connected to the liquid inlet device 101.

[0178] In one embodiment, S61 includes steps S611, S612, S613, S614, S615 and S616.

[0179] S611, switch the three-way valve of the air intake device 102 to connect the inner valve port 111 with the feed valve port 113.

[0180] S612, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the air inlet device 102 and the liquid inlet device 101.

[0181] S613, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 and the feeding valve port 113.

[0182] S614, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the liquid inlet device 101.

[0183] S615, start the material distribution equipment 60, so that the gas passes through the three-way valve of the air inlet device 102, the cleaning pipeline corresponding to the air inlet device 102, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the three-way valve of the liquid inlet device 101, the material conveying pipeline 31 corresponding to the liquid inlet device 101, and the material conveying multi-way valve 40 to the end of the material distribution equipment 60, so as to complete the discharge of residual cleaning liquid and the drying of pipeline.

[0184] S616, shut down the material distribution device 60 and complete the initialization process of the cleaning pipeline and material conveying pipeline 31 connected to the liquid inlet device 101.

[0185] It is understood that when the cleaning pipeline and the material conveying pipeline 31 connected to the air inlet device 102 are being cleaned and sterilized, the cleaning pipeline connected to the liquid inlet device 101 has already been cleaned and sterilized. Therefore, the sterilization of the cleaning pipeline connected to the liquid inlet device 101 can be repeated in subsequent steps, but it will not be repeated.

[0186] In a specific embodiment, the initialization method includes the above steps S0, S111, S112, S113, S114, S115, S116, S117, S118, S211, S212, S213, S311, S312, S313, S314, S315, S316, S317, S318, S411, S412, S413, S414, S415, S511, S512, S513, S611, S612, S613, S614, S615, and S616.

[0187] It is understood that the cleaning solution mentioned above may include water, bleach, acid or alkali solutions, alcohol, organic solvents, etc. The gas may include air, nitrogen, helium, high-temperature steam, etc. The material to be packaged may include reagents, beverages, etc.

[0188] Furthermore, it can be understood that when the in-situ cleaning and dispensing system has multiple liquid inlet devices 101, multiple air inlet devices 102, and multiple feeding devices 103, steps S1, S2, S3 and S4, or S5 and S6 can be selectively executed again. It is understood that the principles of initialization are similar, involving switching or repeating between cleaning / sterilization and evacuation / drying as needed. Therefore, this application will not provide detailed examples of the specific initialization steps for in-situ cleaning devices with different numbers of liquid inlet devices 101, different numbers of air inlet devices 102, and different numbers of feeding devices 103.

[0189] In one embodiment, the cleaning liquid of the liquid inlet device 101 is ethanol, and the gas of the air inlet device 102 is clean air.

[0190] Referring to Figure 11, this application provides a material distribution method 300 for an in-situ cleaning and dispensing system, including the aforementioned in-situ cleaning and dispensing system. A gas-feeding device is defined as an air inlet device 102; a cleaning fluid-feeding device is defined as a liquid inlet device 101; and a material-feeding device for dispensing materials is defined as a feeding device 103. The path formed by the material source 15, reversing valve 11, cleaning pipeline 21, and cleaning multi-way valve of the liquid inlet device 101 is defined as a first cleaning output branch; and the path formed by the material source 15, reversing valve 11, and conveying pipeline 31 of the liquid inlet device 101 to the conveying multi-way valve 40 is defined as a second cleaning output branch. The path is defined as follows: the path formed by the reversing valve 11 of the air intake device 102, the cleaning pipeline 21 to the cleaning multi-way valve is defined as the first gas branch; the path formed by the reversing valve 11 of the air intake device 102, the conveying pipeline 31 to the conveying multi-way valve 40 is defined as the second gas branch; the path formed by the reversing valve 11 of the feeding device 103, the cleaning pipeline 21 to the cleaning multi-way valve is defined as the first material branch; the path formed by the reversing valve 11 of the feeding device 103, the conveying pipeline 31 to the conveying multi-way valve 40 is defined as the second material branch; the path formed by the conveying multi-way valve 40 to the end of the material distribution device 60 is defined as the main material distribution path; the method includes steps Q1, F1 and F2.

[0191] Q1. Select the target material to be packaged. Based on the feeding device 103 where the selected target material to be packaged is located, connect only the second material branch to the main material distribution road. Start the material distribution equipment 60 so that the target material to be packaged is output along the second material branch to the end of the main material distribution road to complete the packaging of the target material to be packaged.

[0192] F1, Select the target cleaning fluid. Based on the feed device 103 where the selected target cleaning fluid is located, connect only the second cleaning output branch to the main distribution road; start the distribution equipment 60 so that the target cleaning fluid is output along the second cleaning output branch to the end of the main distribution road to complete the cleaning of the main distribution road.

[0193] F2, Select the target gas, Based on the gas inlet device 102 where the selected target gas is located, connect only the second gas branch and the main distribution road; Start the distribution equipment 60 to output the target gas along the second gas branch to the end of the main distribution road, so as to complete the venting and drying of the main distribution road.

[0194] Referring to Figure 12, in one embodiment, step Q2 is included after step Q1.

[0195] Q2, determine whether the selected target material to be packaged is the same as the previous material to be packaged; if they are the same, execute step Q1; if they are different, execute steps F1 and F2. Based on the feeding device 103 where the selected target material to be packaged is located, connect only the second material branch to the main material distribution road; start the material distribution equipment 60 so that the target material to be packaged is output along the second material branch to the end of the main material distribution road to complete the packaging of the selected target material to be packaged.

[0196] It is understandable that step Q2 can be executed multiple times until all the required materials to be packaged are packaged.

[0197] Referring to Figure 13, in one embodiment, step H1 is further included after step Q1 and / or step Q2.

[0198] H1, select the pre-recovered packaged material and determine whether the residual material in the main distribution path is the same as the pre-recovered packaged material; if the same, start the distribution equipment 60 in reverse so that the residual material in the second material branch to the end of the main distribution path flows back to the feeding device 103; if different, after executing steps F1 and F2, switch the path to the second material branch and the main distribution path that match the material supply source 15 of the pre-recovered packaged material, start the distribution equipment 60 in reverse so that the residual material in the second material branch to the conveying multi-way valve 40 flows back to the feeding device 103.

[0199] Referring to Figures 11 and 6, in one embodiment, steps S0, S1, S2, S3 and S4 are included before step Q1.

[0200] S0, pre-sterilize the liquid inlet device 101, the air inlet device 102 and the feed device 103.

[0201] S1, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the liquid inlet device 101 performs initial cleaning on the cleaning pipeline 21 and the material conveying pipeline 31 connected to the air inlet device 102.

[0202] S2, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, provides gas and switches the gas flow path, uses the gas of the air intake device 102 to vent the cleaning liquid in the cleaning pipeline 21 and / or the material conveying pipeline 31 connected to the air intake device 102, and dries the cleaning pipeline 21 and / or the material conveying pipeline 31 connected to the air intake device 102.

[0203] S3, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the liquid inlet device 101 performs initial cleaning on the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103.

[0204] S4, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, gas is provided and the flow path of the gas is switched. The cleaning liquid in the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103 is emptied by the gas of the air intake device 102, and the cleaning pipeline 21 and the conveying pipeline 31 connected to the feeding device 103 are dried.

[0205] Referring to Figure 7, further, in some embodiments, steps S5 and S6 are included after step S2 or after step S4.

[0206] S5, through the cooperation of the cleaning multi-way valve group 70, the conveying multi-way valve 40 and each reversing valve 11, provides cleaning fluid and switches the flow path of the cleaning fluid, so that the cleaning fluid of the inlet device 101 performs initial cleaning on the conveying pipeline 31 and / or cleaning pipeline 21 connected to the inlet device 101.

[0207] S6, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, gas is provided and the gas flow path is switched. The gas of the air inlet device 102 is used to vent the cleaning liquid in the material conveying pipeline 31 and the cleaning pipeline 21 connected to the liquid inlet device 101, and to dry the cleaning pipeline 21 and the material conveying pipeline 31 connected to the liquid inlet device 101.

[0208] Referring to Figure 8, further, in one embodiment, S1 includes step S11. In S11, through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, the first cleaning output branch, the first gas branch, the second gas branch and the main material distribution line are connected; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline 21 and the material conveying pipeline 31 connected to the air inlet device 102, and the material distribution equipment 60 is shut down;

[0209] S2 includes step S21. In S21, the second gas branch and the main material distribution line are connected by the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11; the material distribution equipment 60 is started so that the gas in the air inlet device 102 is output along the second gas branch to the end of the main material distribution line, so as to use the gas in the air inlet device 102 to vent the cleaning liquid in the material conveying pipeline 31 connected to the air inlet device 102 and to dry the material conveying pipeline 31 connected to the air inlet device 102; and the material distribution equipment 60 is shut down.

[0210] Referring to Figure 9, further, in one embodiment, S3 includes step S31. In S31, the first cleaning output branch, the first material branch, the second material branch, and the main material distribution line are connected through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and the material distribution equipment 60 is shut down.

[0211] S4 includes step S41. In S41, the first gas branch, the first material branch, and the second material branch are connected to the main distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the distribution equipment 60 is started, so that the gas from the air intake device 102 is output along the first gas branch to the end of the main distribution line, so as to use the gas from the air intake device 102 to vent the cleaning liquid in the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and to dry the cleaning pipeline 21 and the material conveying pipeline 31 connected to the feeding device 103, and then the distribution equipment 60 is shut down.

[0212] Referring to Figure 10, further, in one embodiment, S5 includes step S51. In S51, the second cleaning output branch is connected to the main material distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11; the material distribution equipment 60 is started, so that the cleaning liquid of the liquid inlet device 101 is output along the second cleaning output branch to the end of the main material distribution line, so that the cleaning liquid of the liquid inlet device 101 performs initial cleaning on the material conveying pipeline 31 connected to the liquid inlet device 101.

[0213] S6 includes step S61. In S61, the first gas branch, the first cleaning output branch, and the second cleaning output branch are connected to the main material distribution line through the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40, and each reversing valve 11; the material distribution equipment 60 is started, and the cleaning liquid in the material conveying pipeline 31 and the cleaning pipeline 21 connected to the liquid inlet device 101 is emptied by the gas of the air inlet device 102, and the cleaning pipeline 21 and the material conveying pipeline 31 connected to the liquid inlet device 101 are dried.

[0214] It should be noted that when the flow path of a certain path is connected by the cooperation of the cleaning multi-way valve group 70, the material conveying multi-way valve 40 and each reversing valve 11, it means that all other flow paths are blocked, and gas or cleaning fluid can only flow in that path.

[0215] It should be further noted that each step can be repeated as needed; in other words, multiple cleaning, multiple evacuation, and multiple drying operations are possible. Specific cleaning, evacuation, and drying strategies can be designed and implemented based on the difficulty of cleaning the reagents and the degree of contamination in the tubing. These will not be listed here.

[0216] Furthermore, in one embodiment, the feeding device configured with gas as the feeding source 15 further includes a one-way valve 12 and a filter 13. The reversing valve 11 of the feeding device configured with gas as the feeding source 15 is a three-way valve arranged in an inverted T shape, wherein the inner valve port 111 faces upward and is sequentially connected to the one-way valve 12, the filter 13 and the feeding source 15. The feeding device configured with cleaning liquid or material to be dispensed as the feeding source 15 further includes a storage container 14, a one-way valve 12 and a filter 13. The storage container 14 has a first hole and a second hole, wherein the first hole is connected to the inner valve port 111 of the reversing valve 11, and the second hole is sequentially connected to the one-way valve 12 and the filter 13. Step S0 includes steps S00, S01 and S02.

[0217] S00, the three-way valve, storage container, check valve 12, and filter 13 of the liquid inlet device 101 are subjected to high-pressure and high-temperature sterilization, and the feed source 15 configured as cleaning solution is loaded into the sterilized storage container in an aseptic environment to obtain a pre-sterilized liquid inlet device 101; or, the three-way valve, storage container containing cleaning solution, check valve 12, and filter 13 of the liquid inlet device 101 are subjected to high-pressure and high-temperature sterilization to obtain a pre-sterilized liquid inlet device 101.

[0218] S01, the three-way valve, one-way valve 12, and filter 13 of the air intake device 102 are subjected to high-pressure and high-temperature sterilization, and connected to an air supply source configured as clean gas to obtain a pre-sterilized air intake device 102; or, the air intake device 102 further includes a storage container connected to the side of the filter 13 away from the three-way valve, for storing the material supply source 15; the three-way valve, the storage container containing the material to be dispensed, the one-way valve 12, and the filter 13 of the air intake device 102 are subjected to high-pressure and high-temperature sterilization to obtain a pre-sterilized air intake device 102.

[0219] S02, the three-way valve, storage container, check valve 12, and filter 13 of the feeding device 103 are subjected to high-pressure and high-temperature sterilization, and the material to be packaged is loaded into the sterilized storage container in an aseptic environment to complete the pre-sterilization of the feeding device 103; or, the three-way valve, storage container containing the material to be packaged, check valve 12, and filter 13 of the feeding device 103 are subjected to high-pressure and high-temperature sterilization to complete the pre-sterilization of the feeding device 103.

[0220] It should be noted that steps S00, S01, and S02 can be performed together or separately.

[0221] In one embodiment, S0 includes steps S03 and S04.

[0222] S03, put the liquid inlet device 101, the air inlet device 102 and the feed device 103 into the autoclave for sterilization.

[0223] S04, the cleaning solution is loaded into the sterilized liquid inlet device 101 and storage container 14 under aseptic conditions; the material to be dispensed is loaded into the sterilized feeding device 103 and storage container 14 under aseptic conditions.

[0224] It is understandable that the gas in the air intake device 102 can be directly connected to sterile clean gas during use.

[0225] Furthermore, in one embodiment, the reversing valve 11 is a three-way valve; the cleaning multi-way valve group 70 includes multiple T-type three-way valves 71 arranged in series, with two parallel and opposite valve ports of the multiple T-type three-way valves 71 connected sequentially to form a main bypass channel 701, and the other valve ports of the multiple T-type three-way valves 71 correspondingly forming multiple branch bypass channels 702; wherein, a material supply source 15 is configured as a gas supply device and a material supply source 15 is configured as a cleaning liquid supply device, which are respectively connected horizontally from both sides to the two valve ports at both ends of the main bypass channel 701 through the cleaning pipeline 21. S11 includes steps S111, S112, S113, S114, S115, S116, S117 and S118.

[0226] S111, connecting the material conveying pipeline 31 and the cleaning pipeline 21 corresponding to the liquid inlet device 101, and connecting the material conveying pipeline 31 and the cleaning pipeline 21 corresponding to the air inlet device 102.

[0227] S112, the cleaning pipelines 21 connected to the liquid inlet device 101 and the air inlet device 102 are respectively connected to the valve ports of the cleaning multi-way valve group 70.

[0228] S113, the material conveying pipelines 31 corresponding to the liquid inlet device 101 and the air inlet device 102 are respectively connected to the two material conveying inlets 41 of the material conveying multi-way valve 40.

[0229] S114, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 with the internal valve port 111.

[0230] S115, switch the three-way valve of the air intake device 102 to connect the cleaning valve port 112 and the feeding valve port 113.

[0231] S116, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the liquid inlet device 101 and the air inlet device 102.

[0232] S117, switch the material conveying multi-way valve 40 to connect with the material conveying pipeline 31 corresponding to the air intake device 102.

[0233] S118, start the material distribution equipment 60, so that the cleaning liquid passes through the three-way valve of the liquid inlet device 101, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the air inlet device 102, the three-way valve of the air inlet device 102, the material conveying pipeline 31 corresponding to the air inlet device 102, and the material conveying multi-way valve 40 to the end of the material distribution equipment 60, thereby completing the cleaning and sterilization of the cleaning pipeline and the material conveying pipeline 31 connected to the air inlet device 102.

[0234] In one embodiment, S21 includes steps S211, S212 and S213.

[0235] S211, switch the three-way valve of the air intake device 102 to connect the inner valve port 111 with the feed valve port 113.

[0236] S212, start the material distribution device 60, so that the gas passes through the three-way valve of the air inlet device 102, the corresponding material conveying pipeline 31 of the air inlet device 102, the material conveying multi-way valve 40 and the end of the material distribution device 60, to complete the discharge of cleaning liquid residue and pipeline drying.

[0237] S213, shut down the material distribution equipment 60, and complete the initialization process of the cleaning pipeline and material conveying pipeline 31 connected to the air intake device 102.

[0238] In one embodiment, S31 includes steps S311, S312, S313, S314, S315, S316, S317 and S318.

[0239] S311, connecting the feed pipe 31 and cleaning pipe 21 corresponding to the liquid inlet device 101, and connecting the feed pipe 31 and cleaning pipe 21 corresponding to the feed device 103.

[0240] S312, connect the cleaning pipelines 21 that are connected to the liquid inlet device 101 and the feed device 103 respectively to the valve ports connected to the cleaning multi-way valve group 70.

[0241] S313, the conveying pipelines 31 corresponding to the liquid inlet device 101 and the feed device 103 are respectively connected to the two feed inlets 41 of the conveying multi-way valve 40.

[0242] S314, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 with the internal valve port 111.

[0243] S315, switch the three-way valve of the feeding device 103 to connect the cleaning valve port 112 and the feeding valve port 113.

[0244] S316, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the liquid inlet device 101 and the feed device 103.

[0245] S317, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the feed device 103.

[0246] S318, start the dispensing equipment 60, so that the cleaning fluid passes through the three-way valve of the liquid inlet device 101, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the feeding device 103, the three-way valve of the feeding device 103, the conveying pipeline 31 corresponding to the feeding device 103, and the conveying multi-way valve 40 to the end of the dispensing equipment 60, thereby completing the cleaning and sterilization of the cleaning pipeline and the conveying pipeline 31 connected to the feeding device 103.

[0247] In one embodiment, S41 includes steps S411, S412, S413, S414 and S415.

[0248] S411, switch the three-way valve of the intake device 102 to connect the inner valve port 111 with the cleaning valve port 112.

[0249] S412, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the air intake device 102 and the feeding device 103.

[0250] S413, switch the three-way valve of the feeding device 103 to connect the cleaning valve port 112 and the feeding valve port 113.

[0251] S414, switch the material conveying multi-way valve 40 to connect with the material conveying pipeline 31 corresponding to the feeding device 103.

[0252] S415, start the material distribution equipment 60, so that the gas passes through the three-way valve of the air inlet device 102, the cleaning pipeline corresponding to the air inlet device 102, the main bypass channel 701 of the cleaning multi-way valve group 70, the branch bypass channel 702 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the feeding device 103, the three-way valve of the feeding device 103, the conveying pipeline 31 corresponding to the feeding device 103, and the conveying multi-way valve 40 to the end of the material distribution equipment 60, so as to complete the discharge of residual cleaning liquid and the drying of pipeline.

[0253] S415, shut down the material distribution equipment 60, and complete the initialization process of the cleaning pipeline and conveying pipeline 31 connected to the feeding device 103.

[0254] In one embodiment, S51 includes steps S511, S512 and S513.

[0255] S511, switch the three-way valve of the liquid inlet device 101 to connect the inner valve port 111 with the feed valve port 113.

[0256] S512, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the liquid inlet device 101.

[0257] S513, start the material distribution equipment 60 to complete the cleaning and sterilization of the material conveying pipeline 31 connected to the liquid inlet device 101.

[0258] In one embodiment, S61 includes steps S611, S612, S613, S614, S615 and S616.

[0259] S611, switch the three-way valve of the air intake device 102 to connect the inner valve port 111 with the feed valve port 113.

[0260] S612, close the other valve ports of the cleaning multi-way valve group 70, and keep the main bypass channel 701 connected to the cleaning pipeline 21 corresponding to the air inlet device 102 and the liquid inlet device 101.

[0261] S613, switch the three-way valve of the liquid inlet device 101 to connect the cleaning valve port 112 and the feeding valve port 113.

[0262] S614, switch the multi-way valve 40 to connect to the feed pipeline 31 corresponding to the liquid inlet device 101.

[0263] S615, start the material distribution equipment 60, so that the gas passes through the three-way valve of the air inlet device 102, the cleaning pipeline corresponding to the air inlet device 102, the main bypass channel 701 of the cleaning multi-way valve group 70, the cleaning pipeline 21 corresponding to the liquid inlet device 101, the three-way valve of the liquid inlet device 101, the material conveying pipeline 31 corresponding to the liquid inlet device 101, and the material conveying multi-way valve 40 to the end of the material distribution equipment 60, so as to complete the discharge of residual cleaning liquid and the drying of pipeline.

[0264] S616, shut down the material distribution device 60 and complete the initialization process of the cleaning pipeline and material conveying pipeline 31 connected to the liquid inlet device 101.

[0265] It is understood that during the cleaning and sterilization of the cleaning pipeline and material delivery pipeline 31 connected to the air inlet device 102, the cleaning pipeline connected to the liquid inlet device 101 has already been cleaned and sterilized. Therefore, subsequent steps may or may not repeat the sterilization of the cleaning pipeline connected to the liquid inlet device 101. It is understood that the cleaning solution may include water, bleach, acid or alkali solutions, alcohol, organic solvents, etc. The gas may include air, nitrogen, helium, high-temperature steam, etc. The material to be dispensed may include reagents, beverages, etc.

[0266] Furthermore, it can be understood that when the in-situ cleaning and dispensing system has multiple liquid inlet devices 101, multiple air inlet devices 102, and multiple feeding devices 103, steps S1, S2, S3 and S4, or S5 and S6 can be selectively executed again. It is understood that the principles of initialization are similar, involving switching or repeating between cleaning / sterilization and evacuation / drying as needed. Therefore, this application will not provide detailed examples of the specific initialization steps for in-situ cleaning devices with different numbers of liquid inlet devices 101, different numbers of air inlet devices 102, and different numbers of feeding devices 103.

[0267] In one embodiment, the cleaning liquid of the liquid inlet device 101 is ethanol, and the gas of the air inlet device 102 is clean air.

[0268] For example, in a specific embodiment, the material distribution method of the in-situ cleaning and material distribution system includes the above steps S0, S111, S112, S113, S114, S115, S116, S117, S118, S211, S212, S213, S311, S312, S313, S314, S315, S316, S317, S318, S411, S412, S413, S414, S415, S511, S512, S513, S611, S612, S613, S614, S615, S616, Q1, F1, and F2.

[0269] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0270] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. An in-situ cleaning and dispensing system, characterized in that, It includes a feeding device assembly, a cleaning pipeline assembly, a cleaning multi-way valve assembly, a conveying pipeline assembly, a conveying multi-way valve, and a material distribution device; The feeding device group includes multiple feeding devices, each of which includes a feeding source and a reversing valve. The feeding source of at least one feeding device is gas, the feeding source of at least one feeding device is cleaning fluid, and the feeding source of at least one feeding device is material to be dispensed. The reversing valve has at least three valve ports, defined as an internal valve port, a cleaning valve port, and a feeding valve port. The internal valve port is connected to the feeding source. The cleaning valve port is connected to one valve port of the cleaning multi-port valve group via a cleaning pipeline in the cleaning pipeline group. The feeding valve port is connected to one feed inlet of the feed multi-port valve via a feed pipeline in the feed pipeline group. The dispensing equipment is driven and connected to the feed outlet of the feed multi-port valve. The cleaning multi-way valve group, the material conveying multi-way valve, and each of the reversing valves can cooperate to switch the provided material source and the flow path of the material source, thereby completing in-situ cleaning, in-situ material supply, and in-situ material distribution.

2. The in-situ cleaning and dispensing system according to claim 1, wherein, The reversing valve is a three-way valve.

3. The in-situ cleaning and dispensing system according to claim 1, wherein, The cleaning multi-way valve group includes multiple T-type three-way valves arranged in series. The two valve ports of the multiple T-type three-way valves that are parallel and opposite to each other are connected in sequence to form a main bypass channel. The other valve ports of the multiple T-type three-way valves correspond to form multiple branch bypass channels. Among them, a gas-based feeding device and a cleaning liquid-based feeding device are respectively connected horizontally from both sides to the two valve ports at both ends of the main bypass channel through the cleaning pipeline. Alternatively, the cleaning multi-way valve assembly includes a multi-inlet single-outlet multi-way switching valve and a single-inlet multi-outlet multi-way switching valve arranged in series.

4. The in-situ cleaning and dispensing system according to claim 1, wherein, The feeding device, in which the feeding source is configured as gas, further includes a one-way valve and a filter. The reversing valve of the feeding device, in which the feeding source is configured as gas, is an inverted T-type three-way valve, wherein the inner valve port faces upward and is sequentially connected to the one-way valve, the filter, and the feeding source.

5. The in-situ cleaning and dispensing system according to claim 4, wherein, The feeding device, wherein the feeding source is configured as gas, further includes a storage container connected to the side of the filter away from the reversing valve, for storing the feeding source configured as gas.

6. The in-situ cleaning and dispensing system according to claim 1, wherein, The feeding device, in which the feeding source is configured as cleaning fluid or material to be packaged, further includes a storage container and a filter. The storage container has a first hole and a second hole, wherein the first hole is connected to the inner valve port of the reversing valve, and the second hole is connected to the filter.

7. The in-situ cleaning and dispensing system according to claim 6, wherein, The feeding device, in which the feeding source is configured as cleaning fluid or material to be packaged, further includes a one-way valve, and the second port is connected to the filter through the one-way valve.

8. The in-situ cleaning and dispensing system according to claim 7, wherein, The storage container includes a receiving portion and a sealing portion connected to each other, and the first hole and the second hole are formed in the sealing portion; The sealing part, the one-way valve, the reversing valve, and the filter are integrated into one unit.

9. The in-situ cleaning and dispensing system according to claim 1, wherein, The material conveying multi-way valve is a multi-inlet single-outlet or multi-inlet multiple-outlet multi-way switching valve; and / or The gas includes one or more of air, nitrogen, helium, and high-temperature steam; and / or, The cleaning solution includes one or more of the following: bleach, acid / alkali solution, organic solvent, alcohol, water, and high-temperature steam.

10. The in-situ cleaning and dispensing system according to claim 1, wherein, It also includes a liquid dispensing multi-port head, and the dispensing device is connected to one of the conveying outlets of the conveying multi-port valve through the liquid dispensing multi-port head.

11. The in-situ cleaning and dispensing system according to claim 10, wherein, The liquid dispensing multi-port head includes a main flow channel and multiple branch flow channels connected to the same end of the main flow channel; one end of the main flow channel away from the branch flow channels is connected to the material outlet of the material conveying multi-port valve; the other ends of the multiple branch flow channels are respectively connected to multiple dispensing inlets of the dispensing equipment. The branch channels are arranged symmetrically around the central axis of the main channel, and the central axis of each branch channel has an angle with the central axis of the main channel, which is a right angle or an acute angle.

12. The in-situ cleaning and dispensing system according to claim 11, wherein, The included angle is defined in degrees as α, where 20° ≤ α ≤ 60°; and / or, The multiple branch channels have the same channel shape; and / or, The inner walls of the multiple branch flow channels have the same surface finish; and / or, The lengths of the multiple branch channels are equal; and / or, The inner diameters of the plurality of said branch channels are equal; and / or, The central axes of the multiple branch channels intersect at the same point on the central axis of the main channel.

13. The in-situ cleaning and dispensing system according to claim 11, wherein, Each of the branch channels includes a confluence section and a connector section that are coaxially arranged and interconnected. The end of the confluence section opposite to the connector section is connected to the main channel, and the connector section is used to connect to the material distribution equipment. The inner diameter of the connector section is larger than the inner diameter of the manifold section, so as to form a sealing end face at the junction of the connector section and the manifold section.

14. The in-situ cleaning and dispensing system according to claim 13, wherein, The dispensing equipment includes a conveying pump, a dispensing pipeline, and a dispensing connector. The conveying pump has at least one dispensing inlet and at least one dispensing outlet. The dispensing connector has a first insertion end and a second insertion end facing away from each other. The first insertion end is inserted into the connector section, and the end face of the first insertion end abuts against the sealing end face. The second insertion end is connected to one of the dispensing inlets through the dispensing pipeline.

15. The in-situ cleaning and dispensing system according to claim 14, wherein, It also includes a liquid dispensing nozzle, which is installed at the dispensing outlet at the end of the dispensing equipment.

16. The in-situ cleaning and dispensing system according to claim 10, wherein, Along the direction of gravity, the liquid dispensing multi-port head is installed above the material conveying multi-port valve.

17. The in-situ cleaning and dispensing system according to claim 10, wherein, The in-situ cleaning and dispensing system also includes a housing, in which at least the material conveying multi-way valve and the liquid dispensing multi-way head are installed, and at least part of the housing is a transparent shell, which is used to observe the pipe body connected to the material conveying multi-way valve and the liquid dispensing multi-way head.

18. The in-situ cleaning and dispensing system according to claim 17, wherein, The outer shell includes a lower support shell and an upper protective shell that are connected to each other, and the upper protective shell is a transparent shell.

19. The in-situ cleaning and dispensing system according to claim 18, wherein, The upper protective shell includes a circumferential baffle and a cover, the cover being placed on top of the circumferential baffle and circumferentially blocking part of the side wall of the circumferential baffle.

20. The in-situ cleaning and dispensing system according to claim 19, wherein, The in-situ cleaning and dispensing device further includes at least one pipe organizing component, which is installed on the housing, and at least one side of the pipe organizing component has a plurality of receiving slots for accommodating pipe bodies.

21. The in-situ cleaning and dispensing system of claim 20, wherein the pipeline arrangement component is detachably mounted on the housing.

22. The in-situ cleaning and dispensing system according to claim 20, wherein, The pipe arrangement component has a mounting groove on at least one side, and the pipe arrangement component is secured to the top edge of the circumferential baffle through the mounting groove, located between the cover and the circumferential baffle; or, The pipe arrangement component has a mounting protrusion on at least one side, and the protective shell has a snap-fit ​​hole. The pipe arrangement component is installed on the protective shell by the cooperation of the mounting protrusion and the snap-fit ​​hole.

23. The in-situ cleaning and dispensing system according to claim 10, wherein, It also includes a first liquid receiving component, which circumferentially surrounds the periphery of the feed multi-way valve and the liquid dispensing multi-way head, and is located below the feed inlet of the feed multi-way valve; and / or, The dispensing equipment also includes a second liquid receiving component, which is located below the dispensing outlet.

24. The in-situ cleaning and dispensing system according to claim 23, wherein, It also includes a drain pipe, through which the first liquid receiving component is connected to the second liquid receiving component.

25. The in-situ cleaning and dispensing system according to claim 23, wherein, It also includes a collection device, which comprises a storage unit, a collection tube, and an anti-reversion structure. The collection tube has an inlet and an outlet. The outlet is connected to the storage unit, and the inlet is connected to the first liquid receiving component and / or the second liquid receiving component. Waste liquid enters the collection tube from the inlet and enters the storage unit through the outlet. The anti-backflow structure is provided between the input port and the output port to prevent waste liquid entering the storage device from flowing back to the output port and / or evaporating.

26. The in-situ cleaning and dispensing system according to claim 25, wherein, The anti-reversion structure is configured as a portion of the collection tube, and the portion of the tube is U-shaped and bent into a liquid-sealed buffer chamber into which a barrier liquid can be injected; or, the anti-reversion structure is configured as a one-way valve or a float valve.

27. The in-situ cleaning and dispensing system according to claim 25, wherein, The storage device is provided with an exhaust port, and a gas filter is provided at the exhaust port.

28. The in-situ cleaning and dispensing system according to claim 27, wherein, The gas filter includes an activated carbon filter.

29. The in-situ cleaning and dispensing system according to claim 27, wherein, The storage device includes a container bottle and a container cap that are connected to each other, and the exhaust port is located on the container cap; the gas filter is an integral structure with the container cap.

30. A multi-channel liquid separator, characterized in that, The multi-channel liquid separator includes a main flow channel and multiple branch flow channels, with one end of each branch flow channel connected to the same end of the main flow channel. The branch channels are arranged symmetrically around the central axis of the main channel, and the central axis of each branch channel has an angle with the central axis of the main channel, and the angles are all right angles or acute angles.

31. The multi-channel liquid separator according to claim 30, wherein, The included angle is defined in degrees as α, where 20° ≤ α ≤ 60°; and / or, The multiple branch channels have the same channel shape; and / or, The inner walls of the multiple branch flow channels have the same surface finish; and / or, The lengths of the multiple branch channels are equal; and / or, The inner diameters of multiple branch channels are the same; and / or, The central axes of the multiple branch channels intersect at the same point on the central axis of the main channel.

32. The multi-channel liquid separator according to claim 30, wherein, Each of the branch channels includes a coaxially arranged and interconnected merging section and a connector section, with the end of the merging section opposite to the connector section connected to the main channel; The inner diameter of the connector section is larger than the inner diameter of the manifold section, so as to form a sealed connection end face at the junction of the connector section and the manifold section, and the sealed connection end face can abut against the external connector surface.

33. A collection device, characterized in that, It includes a storage device and a collection tube, the collection tube having an inlet and an outlet, the outlet being connected to the storage device, the object to be collected entering the collection tube from the inlet and entering the storage device through the outlet; An anti-return structure is provided between the input port and the output port to prevent the material to be collected from flowing back into the storage device to the output port.

34. The collecting device according to claim 33, wherein, The anti-reversion structure is configured as a portion of the collection tube, and the portion of the tube is U-shaped to form a liquid-sealed buffer chamber into which barrier liquid can be injected; or, The anti-reversion structure is configured as a one-way valve or a float valve.

35. The collecting device according to claim 33, wherein, The storage device is provided with an exhaust port, and a gas filter is provided at the exhaust port.

36. The collecting device according to claim 35, wherein, The gas filter includes an activated carbon filter.

37. The collecting device according to claim 35, wherein, The storage device includes a container bottle and a container cap that are connected to each other, and the exhaust port is located on the container cap; the gas filter is an integral structure with the container cap.

38. An initialization method for an in-situ cleaning and material distribution system, characterized in that, Based on the in-situ cleaning and dispensing system according to any one of claims 1-29, a feeding device whose feeding source is gas is defined as an air inlet device, a feeding device whose feeding source is cleaning fluid is defined as a liquid inlet device, and a feeding device whose feeding source is the material to be dispensed is defined as a feeding device; the method includes: S0, pre-sterilize the liquid inlet device, the air inlet device and the feed inlet device; S1, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and material conveying pipeline connected to the air inlet device. S2, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, gas is provided and the gas flow path is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and / or material conveying pipeline connected to the air inlet device, and to dry the cleaning pipeline and / or material conveying pipeline connected to the air inlet device. S3, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and conveying pipeline connected to the feeding device. S4, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, gas is provided and the flow path of the gas is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and conveying pipeline connected to the feeding device, and to dry the cleaning pipeline and conveying pipeline connected to the feeding device.

39. The initialization method of the in-situ cleaning and dispensing system according to claim 38, wherein, The path formed by the liquid inlet device's supply source, reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first clean output branch; the path formed by the liquid inlet device's supply source, reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second clean output branch; the path formed by the air inlet device's reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first gas branch; the path formed by the air inlet device's reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second gas branch; the path formed by the feed inlet device's reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first material branch; the path formed by the feed inlet device's reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second material branch; the path formed by the conveying multi-way valve to the end of the distribution equipment is defined as the main distribution path. S1 includes the following steps: S11, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, the first cleaning output branch, the first gas branch, the second gas branch and the main material distribution line are connected; the material distribution equipment is started, so that the cleaning liquid of the liquid inlet device is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline and the material conveying pipeline connected to the gas inlet device, and the material distribution equipment is shut down; S2 includes the following steps: S21, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, the second gas branch and the main material distribution line are connected; the material distribution equipment is started, so that the gas in the air inlet device is output along the second gas branch to the end of the main material distribution line, so as to use the gas in the air inlet device to vent the cleaning liquid in the material conveying pipeline connected to the air inlet device, and to dry the material conveying pipeline connected to the air inlet device, and then the material distribution equipment is shut down.

40. The initialization method of the in-situ cleaning and dispensing system according to claim 39, wherein, S3 includes the following steps: S31, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, the first cleaning output branch, the first material branch, the second material branch and the main material distribution route are connected; Start the material distribution equipment so that the cleaning fluid of the liquid inlet device is output along the first cleaning output branch to the end of the main material distribution line, thereby completing the initial cleaning of the cleaning pipeline and conveying pipeline connected to the liquid inlet device, and then shut down the material distribution equipment. S4 includes the following steps: S41, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, the first gas branch, the first material branch, and the second material branch are connected to the main material distribution line; the material distribution equipment is started, so that the gas from the air inlet device is output along the first gas branch to the end of the main material distribution line, so as to use the gas from the air inlet device to vent the cleaning liquid in the cleaning pipeline and conveying pipeline connected to the feeding device, and to dry the cleaning pipeline and conveying pipeline connected to the feeding device, and then the material distribution equipment is shut down.

41. The initialization method of the in-situ cleaning and dispensing system according to claim 38, wherein, The initialization method further includes the following step after step S2 or after step S4: S5, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the material conveying pipeline and / or cleaning pipeline connected to the liquid inlet device. S6, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, gas is provided and the gas flow path is switched. The gas from the air inlet device is used to vent the cleaning liquid in the material conveying pipeline and cleaning pipeline connected to the liquid inlet device, and to dry the cleaning pipeline and material conveying pipeline connected to the liquid inlet device.

42. The initialization method of the in-situ cleaning and dispensing system according to claim 41, wherein, The path formed by the liquid inlet device's supply source, reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first clean output branch; the path formed by the liquid inlet device's supply source, reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second clean output branch; the path formed by the air inlet device's reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first gas branch; the path formed by the air inlet device's reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second gas branch; the path formed by the feed inlet device's reversing valve, cleaning pipeline to the cleaning multi-way valve is defined as the first material branch; the path formed by the feed inlet device's reversing valve, conveying pipeline to the conveying multi-way valve is defined as the second material branch; the path formed by the conveying multi-way valve to the end of the distribution equipment is defined as the main distribution path. S5 includes the following steps: S51, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, the second cleaning output branch is connected to the main material distribution line; the material distribution equipment is started, so that the cleaning liquid of the liquid inlet device is output along the second cleaning output branch to the end of the main material distribution line, so that the cleaning liquid of the liquid inlet device performs initial cleaning on the material conveying pipeline connected to the liquid inlet device. S6 includes the following steps: S61, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, the first gas branch, the first cleaning output branch, and the second cleaning output branch are connected to the main material distribution line; the material distribution equipment is started, and the cleaning liquid in the material conveying pipeline and cleaning pipeline connected to the liquid inlet device is emptied by the gas of the air inlet device, and the cleaning pipeline and material conveying pipeline connected to the liquid inlet device are dried.

43. A material distribution method for an in-situ cleaning and material distribution system, characterized in that, Based on the in-situ cleaning and dispensing system according to any one of claims 1-29, a feeding device with a gas supply source is defined as an air inlet device, a feeding device with a cleaning liquid supply source is defined as a liquid inlet device, and a feeding device with a material to be dispensed as a feeding device; the path formed by the supply source, reversing valve, cleaning pipeline, and cleaning multi-way valve of the liquid inlet device is defined as the first cleaning output branch, and the path formed by the supply source, reversing valve, conveying pipeline, and conveying multi-way valve of the liquid inlet device is defined as the second cleaning output branch; the path formed by the reversing valve, cleaning pipeline, and cleaning multi-way valve of the air inlet device is defined as the first gas branch, and the path formed by the reversing valve, conveying pipeline, and conveying multi-way valve of the air inlet device is defined as the second gas branch; the path formed by the reversing valve, cleaning pipeline, and cleaning multi-way valve of the feeding device is defined as the first material branch, and the path formed by the reversing valve, conveying pipeline, and conveying multi-way valve of the feeding device is defined as the second material branch. The path formed from the material conveying multi-way valve to the end of the material distribution equipment is defined as the main material distribution path; The method includes: Q1, Select the target material to be packaged, and based on the feeding device where the selected target material to be packaged is located, connect only the second material branch to the main material distribution road; start the material distribution equipment so that the target material to be packaged is output along the second material branch to the end of the main material distribution road to complete the packaging of the target material to be packaged; F1, Select target cleaning fluid. Based on the feeding device where the selected target cleaning fluid is located, connect only the second cleaning output branch to the main distribution road; start the distribution equipment to output the target cleaning fluid along the second cleaning output branch to the end of the main distribution road, so as to complete the cleaning of the main distribution road; F2, Select target gas, based on the gas inlet device where the selected target gas is located, connect only the second gas branch and the main distribution line; start the distribution equipment to output the target gas along the second gas branch to the end of the main distribution line, so as to complete the venting and drying of the main distribution line.

44. The material distribution method of the in-situ cleaning and material distribution system according to claim 43, wherein, The step following step Q1 is: Q2, determine whether the selected target material to be packaged is the same as the previous material to be packaged; If they are the same, proceed to step Q1; if they are different, proceed to steps F1 and F2. Based on the feeding device where the selected target material to be packaged is located, connect only the second material branch to the main material distribution road; start the material distribution equipment so that the target material to be packaged is output along the second material branch to the end of the main material distribution road to complete the packaging of the selected target material to be packaged.

45. The material distribution method of the in-situ cleaning and material distribution system according to claim 44, wherein, The steps following step Q1 and / or step Q2 include: H1, select the pre-recovered packaged material and determine whether the residual material in the main distribution path is the same as the pre-recovered packaged material. If the materials are the same, the material distribution equipment is started in reverse, so that the residual materials in the second material branch to the end of the main material distribution road flow back to the feeding device. If they are different, after executing steps F1 and F2, the path is switched to the second material branch and the main material distribution path that match the feeding source of the pre-recovered packaged material, and the material distribution equipment is started in reverse so that the residual material in the second material branch to the conveying multi-way valve flows back to the feeding device.

46. ​​The material distribution method of the in-situ cleaning and material distribution system according to claim 43, wherein, The following steps precede step Q1: S0, pre-sterilize the liquid inlet device, the air inlet device and the feed inlet device; S1, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and material conveying pipeline connected to the air inlet device. S2, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, gas is provided and the gas flow path is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and / or material conveying pipeline connected to the air inlet device, and to dry the cleaning pipeline and / or material conveying pipeline connected to the air inlet device. S3, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the cleaning pipeline and conveying pipeline connected to the feeding device. S4, through the cooperation of the cleaning multi-way valve group, the conveying multi-way valve and each of the reversing valves, gas is provided and the flow path of the gas is switched. The gas of the air inlet device is used to vent the cleaning liquid in the cleaning pipeline and conveying pipeline connected to the feeding device, and to dry the cleaning pipeline and conveying pipeline connected to the feeding device.

47. The material distribution method of the in-situ cleaning and material distribution system according to claim 46, wherein, The material distribution method further includes the following steps after step S2 or step S4: S5, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, cleaning fluid is provided and the flow path of the cleaning fluid is switched, so that the cleaning fluid of the liquid inlet device performs initial cleaning on the material conveying pipeline and / or cleaning pipeline connected to the liquid inlet device. S6, through the cooperation of the cleaning multi-way valve group, the material conveying multi-way valve and each of the reversing valves, gas is provided and the gas flow path is switched. The gas from the air inlet device is used to vent the cleaning liquid in the material conveying pipeline and cleaning pipeline connected to the liquid inlet device, and to dry the cleaning pipeline and material conveying pipeline connected to the liquid inlet device.

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