Ternary herbicidal composition and use thereof

Abstract

The present invention relates to the field of pesticides, and in particular to a ternary herbicidal composition and a use thereof. The ternary herbicidal composition comprises herbicidally effective amounts of active ingredient A, active ingredient B and active ingredient C, wherein the active ingredient A is represented by formula (I) or (II), the active ingredient B is atrazine or terbutylazine, and the active ingredient C is mesotrione, fenpyrazone or topramezone. The composition can effectively control various weed problems such as grasses and broadleaf weeds, and has the characteristics of expanding the herbicidal spectrum, reducing the application rate, producing a synergistic effect, and addressing resistant weeds.

Description

A ternary herbicidal composition and application thereof TECHNICAL FIELD

[0001] The present application belongs to the field of pesticides, and particularly relates to a ternary herbicidal composition and application thereof. BACKGROUND

[0002] Chemical weeding is the most economical and effective means in the prevention and control of weeds in farmland, but long-term continuous high-dose use of single variety or single action mode of chemical herbicides can easily cause weed tolerance and resistance evolution and other problems.

[0003] Reasonable compounding or mixing of herbicide compounds has the advantages of expanding the weed spectrum, improving the prevention and control effect, delaying the occurrence and development of weed tolerance and resistance, and the like, and is one of the most effective methods for solving the above problems. Therefore, it is urgent to develop a herbicidal composition variety with high safety, wide weed spectrum, synergistic effect and resistance to resistant weeds in production. SUMMARY

[0004] To solve the above problems in the prior art, the present application provides a ternary herbicidal composition and application thereof, which can effectively prevent and control various weed problems such as gramineae and broadleaf weeds, has the characteristics of expanding the weed spectrum, reducing the application amount, producing synergistic effect and solving resistant weeds, and the like.

[0005] A ternary herbicidal composition, comprising herbicidal effective amounts of active ingredient A, active ingredient B and active ingredient C, wherein,

[0006] The active ingredient A is

[0007] The active ingredient B is atrazine (CAS No. 1912-24-9) or terbumeton (CAS No. 5915-41-3);

[0008] The active ingredient C is mesotrione (CAS No. 104206-82-8), benzofluor (CAS No. 1992017-55-6) or pyroxasulfone (CAS No. 210631-68-8).

[0009] In one specific embodiment, the weight ratio of A, B and C is 1-100:1-1000:1-100, 2-50:5-800:2-80, 5-35:20-600:3-60, 7-30:40-300:4-30, 8-20:75-200:7-15 or 10-15:100-160:8-10.

[0010] The mass percentage of A, B and C in the herbicidal composition accounts for 1-95% of the total amount, preferably 10-80%.

[0011] The herbicidal compositions also comprise conventional adjuvants, including carriers and / or surfactants.

[0012] The term "carrier" in the present context means an organic or inorganic, natural or synthetic substance. They facilitate the application of the active ingredients, the carrier is generally inert and must be agriculturally acceptable, in particular by the plants treated. The carrier can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc., or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorinated hydrocarbons, liquefied gases, etc.

[0013] The surfactants can include emulsifiers, dispersants or wetting agents, which can be ionic or non-ionic. Examples that can be mentioned are salts of polyacrylic acid, lignosulphonic acid salts, salts of phenol or naphthalene sulphonic acid, polymers of ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines and substituted phenols, in particular alkylphenols or arylphenols, sulphosuccinic acid salts, taurine derivatives, in particular alkyl taurates, and phosphoric esters of alcohols or polyhydroxyethylated phenols, alkylsulphonic acid salts, alkylaryl sulphonic acid salts, alkyl sulphates, lauryl ether sulphates, fatty alcohol sulphates, and sulphated hexa-, hepta- and octadecanol, and sulphated fatty alcohol glycol ethers, furthermore condensates of naphthalene or of naphthalenesulphonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octyl- or nonylphenol, alkylphenyl polyglycol ethers, tributylphenyl polyglycol ether, tristearylphenyl polyglycol ether, alkylaryl polyether alcohols, alcohol and fatty alcohol / ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene, lauryl alcohol polyglycol ether formal, sorbitol esters, lignosulphite waste liquors, and proteins, denatured proteins, polysaccharides (e.g. methylcellulose), hydrophobically modified starches, polyvinyl alcohol, polycarboxylates, polyalkoxylates, polyvinylamines, polyvinylpyrrolidone and copolymers thereof. At least one surfactant is required to be present in order to facilitate the dispersion of the active ingredients in water and to enable them to be applied correctly to the plants.

[0014] The above-mentioned compositions can also contain various other components, such as protective colloids, binders, thickeners, thixotropic agents, penetration agents, stabilizers, sequestering agents, dyes, colorings and polymers.

[0015] The herbicidal composition further comprises at least one safener, preferably one or more of benzenesulfoxylic acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), dichlormid (CAS: 135590-91-9), cloquintocet (CAS: 99607-70-2), gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).

[0016] In the context of the present specification, if an abbreviation of the common name of an active compound is used, all conventional derivatives, such as esters and salts, as well as isomers, in particular optical isomers, in particular one or more commercial forms, are included in each case. If the common name denotes an ester or salt, all other conventional derivatives, such as further esters and salts, free acids and neutral compounds, as well as isomers, in particular optical isomers, in particular one or more commercial forms, are also included in each case. The chemical name of a compound given indicates at least one compound encompassed by the common name, typically the preferred compound. In the case of sulfonamides, such as sulfonylureas, salts also include salts formed by exchange of the hydrogen atom in the sulfonamide group by a cation.

[0017] In the context of the present application, the salts of the compounds are preferably in the form of the respective alkali metal salts, alkaline earth metal salts or ammonium salts, preferably in the form of the respective alkali metal salts, more preferably in the form of the respective sodium or potassium salts, most preferably in the form of the respective sodium salts.

[0018] The compositions of the present application can be used directly or diluted by the user prior to use. They are prepared by the customary methods of processing, i.e. by mixing the active substances with extenders, solvents, or solid carriers, liquid solvents or granular carriers, if desired with surfactants and, if appropriate, agents for altering the physical state and in some cases other processing auxiliaries.

[0019] The herbicidal composition is specifically formulated as dispersible oil suspension, aqueous suspension, suspoemulsion, wettable powder, emulsifiable concentrate, water dispersible granule (dry flowable), water emulsion, microemulsion.

[0020] In short, the compositions of the present application can be mixed with solid and liquid additives conventionally used in the formulations of the prior art. The amount of active ingredient used varies with the external conditions, such as temperature, humidity, nature of the herbicide used, etc. It can vary within wide limits, for example between 0.001 and 1.0 kg / ha, or more of active substance, but preferably between 0.005 and 750 g / ha, in particular between 0.005 and 500 g / ha.

[0021] In addition, the composition of the present application can be applied to the leaves of the plants to be treated, i.e. to the weeds, in particular to the surface affected by or susceptible to weed infestation, by the method of spraying.

[0022] Further, the present application also provides the use of the herbicidal composition in controlling weeds; and a method for controlling the growth of unwanted plants, which comprises applying the herbicidal composition to the plants, plant parts, plant seeds or the area where the plants grow. Preferably, the herbicidal composition is used for selectively controlling weeds in useful crops, more preferably, the useful crops are genetically modified crops or crops treated by genome editing technology.

[0023] The compounds of the present application can be used to treat all plants and plant parts. Plant varieties and cultivars can be obtained by conventional methods of breeding and selection or by genetic engineering methods. Genetically modified plants (GM plants) are plants whose genetic material has been modified by the use of recombinant DNA techniques. The modification of the genetic material can be done to improve certain properties of the plants, such as herbicide tolerance or resistance to pests or to improve nutritional value.

[0024] Genetically modified plant cultivars that can be treated according to the application include plants that are resistant to one or more biotic stresses (pests, such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, cold, soil minerals, etc.) or that comprise other desirable characteristics. Plants can be genetically modified to exhibit traits such as herbicide tolerance, insect resistance, modified oil profile, or drought resistance. Information on useful genetically modified plants comprising single gene transformation events or combinations of transformation events is available, for example, from the publicly available database of the U.S. Department of Agriculture.

[0025] When applying the herbicidal composition of the present application, its herbicidal activity is unexpectedly synergistically enhanced relative to the single agents and any of the binary combinations thereof. The synergistic effect is manifested in reduced application rates, a broader spectrum of weed control, faster and more persistent herbicidal action, which are desirable in weed control practices. In terms of the described properties, the new compositions are clearly superior to existing herbicides, achieving reduced use rates and being more environmentally friendly.

[0026] The synergistic herbicidal composition of the present application also has the following advantages:

[0027] (1) The composition of the present application is environmentally friendly and easily degradable in the environment.

[0028] (2) The herbicidal composition of the present application is low in cost and easy to use, and its popularization and application have great economic and social benefits. DETAILED DESCRIPTION

[0029] The following examples are not intended to limit the present application, but merely serve to illustrate how the present application can be carried out. The examples show particularly significant effectiveness for some weeds. Examples are as follows:

[0030] Pharmacodynamic test

[0031] 1) Test target: Japanese brome, Galium aparine, bluegrass.

[0032] 2) Culture condition

[0033] It was carried out in a controlled sunlight greenhouse, with temperature 20-30°C, natural light, and relative humidity 55%-75%.

[0034] The soil type was loam, with organic matter content 1.63%, pH = 7.1, alkali hydrolysis nitrogen 84.3 mg / kg, available phosphorus 38.5 mg / kg, and available potassium 82.1 mg / kg. The test soil was quantitatively filled to 3 / 4 of the pot, then irrigated from the bottom of the pot to completely wet the soil to saturation. The seeds of the test weeds were treated to germinate, then uniformly and quantitatively sowed on the surface, covered with 0.5-1 cm soil according to the size of the seeds, and reserved after sowing.

[0035] 3) Test agent

[0036] The required active ingredient was purchased from a reagent company or synthesized according to a conventional method. The technical agent was diluted with acetone as solvent, with 0.1% emulsifier Tween-80 aqueous solution, and freshly diluted.

[0037] Water without the agent, containing the same solvent and emulsifier, was used as a blank control.

[0038] 4) Experimental method (soil closure)

[0039] Each treatment was repeated 4 times, with 3 pots per treatment each time, and 30 seeds of the weeds sowed per pot.

[0040] Irrigation was carried out before treatment, with a 1-2 cm water layer maintained. A pipette was used to take a quantitative amount of the agent, which was irrigated according to the test design from low to high dose, with 4 repeated treatments each time. After treatment, it was moved into the greenhouse for conventional culture, with a 1-2 cm water layer maintained during the test period.

[0041] 5) Data investigation and statistical analysis

[0042] 5.1) Investigation method

[0043] The absolute number investigation method was used, with a blade used to cut the surviving weed seedlings along the soil surface, and the fresh weight of the weeds weighed with an analytical balance. For the weeds that had died, the fresh weight was taken as zero.

[0044] 5.2) Investigation time and frequency

[0045] Investigation after 25 days of treatment, 1 time in total.

[0046] 5.3) Statistical analysis of data

[0047] The Colby method was used to evaluate the combined effect of any two or three herbicides on weeds.

[0048] At 25d, the green tissue above ground was cut from each treatment plot and weighed on an electronic balance to calculate the actual survival rate: E(%)=(treated area weed fresh weight / control area weed fresh weight) x 100

[0049] The theoretical weed survival rate calculation formula is: E0(%)=X x Y / 100 (binary mixture)

[0050] Where X represents the weed survival rate of A when the dosage is P, Y represents the weed survival rate of B when the dosage is Q, E0 represents the theoretical weed survival rate of A+B when the dosage is (P+Q), and E represents the actual weed survival rate of each treatment.

[0051] E0(%)=X x Y x Z x…x N / 100 (n-1) (trinary and above mixtures)

[0052] Where X, Y, Z, N represent the actual survival rates of n single agents, and n is the number of herbicide varieties in the mixture.

[0053] When E0-E>10%, it indicates a synergistic effect; when E0-E<-10%, it indicates an antagonistic effect; and when E0-E is between ±10%, it indicates an additive effect.

[0054] The actual control effect of each component on weeds and the combined effect evaluation statistical results are shown in Tables 1-6 below.

[0055] Table 1A is B is atrazine, C is mesotrione, and the weed is Japanese brome

[0056] Table 2A is B is atrazine, C is benzofluor, and the weed is Japanese brome

[0057] Table 3A is B is atrazine, C is benzofluor, and the weed is Japanese brome

[0058] Table 4A is B is terbuthylazine, C is mesotrione, and the weed is Galium aparine

[0059] Table 5A is B is terbumeton, C is benzofluor, and the weed is bluegrass

[0060] Table 6A is B is terbumeton, C is benzofluor, and the weed is chickweed Note: E(A): measured fresh weight survival rate of component A treatment at a given dose E(B): measured fresh weight survival rate of component B treatment at a given dose E(C): measured fresh weight survival rate of component C treatment at a given dose E(A+B): measured fresh weight survival rate of binary mixture of component A and component B at a given dose E(A+C): measured fresh weight survival rate of binary mixture of component A and component C at a given dose E(B+C): measured fresh weight survival rate of binary mixture of component B and component C at a given dose E(A+B+C): measured fresh weight survival rate of ternary mixture of components A, B, C at a given dose E0(A+B+C): theoretical fresh weight survival rate of ternary mixture of components A, B, C at a given dose E0((A+B)+C): theoretical fresh weight survival rate of binary mixture of components A, B as a whole and component C at a given dose E0((A+C)+B): theoretical fresh weight survival rate of binary mixture of components A, C as a whole and component B at a given dose E0(A+(B+C)): theoretical fresh weight survival rate of binary mixture of components B, C as a whole and component A at a given dose

[0061] After a large number of experiments and explorations, the present application surprisingly found that the composition has a surprising and unexpected synergistic effect for preventing a variety of gramineae and broadleaf weeds, and the synergistic effect is more significant at a low dose, which can reduce the amount of drug, reduce environmental pollution, and reasonable compounding reduces the cost of agricultural use, and has a good application prospect.

Claims

1. A ternary herbicidal composition, characterized by comprising: comprising a herbicidally effective amount of active ingredient A, active ingredient B and active ingredient C, wherein Active ingredient A is active ingredient B is atrazine or terbumeton; active ingredient C is mesotrione, carfentrazone-ethyl or oxadiazon.

2. The ternary herbicidal composition according to claim 1, characterized by wherein the weight ratio of A, B and C is 1-100:1-1000:1-100, 2-50:5-800:2-80, 5-35:20-600:3-60, 7-30:40-300:4-30, 8-20:75-200:7-15 or 10-15:100-160:8-10.

3. The ternary herbicidal composition according to claim 1 or 2, characterized by the mass percentage of A, B and C in the herbicidal composition is 1-95%, preferably 10-80% of the total amount.

4. The ternary herbicidal composition according to claim 1 or 2, characterized by, the herbicidal composition further comprises conventional adjuvants, preferably the conventional adjuvants comprise carriers and / or surfactants.

5. The ternary herbicidal composition according to claim 1 or 2, characterized by, the herbicidal composition further comprises at least one safener, preferably the safener is selected from one or more of isoxadifen-ethyl, cyprosulfamide, metcamifen, furilazole and cloquintocet.

6. The ternary herbicidal composition according to any one of claims 1 to 5, characterized in that, the specific formulation of the herbicidal composition is dispersible oil suspension, aqueous suspension, suspoemulsion, wettable powder, emulsifiable concentrate, water dispersible granule, aqueous emulsion or microemulsion.

7. Use of the ternary herbicidal composition according to any one of claims 1-6 for controlling weeds, preferably the herbicidal composition is used for selectively controlling weeds in useful crops, more preferably the useful crops are genetically modified crops or crops treated by genome editing technology.

8. A method for controlling unwanted plant growth, comprising applying the ternary herbicidal composition according to any one of claims 1-6 to plants, plant parts, plant seeds or areas where plants grow, preferably the herbicidal composition is used for selectively controlling weeds in useful crops, more preferably, the useful crops are genetically modified crops or crops treated by genome editing technology.

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