Cylindrical leukocyte reduction filter having radial flow field and filtering method therefor

Abstract

Disclosed in the present invention are a cylindrical leukocyte reduction filter having a radial flow field and a filtering method therefor. The cylindrical leukocyte reduction filter having a radial flow field allows a blood raw material to diffuse by means of a radial flow and uniformly pass through an annular filtration membrane layer. The cylindrical leukocyte reduction filter of the present invention has a simple structure, and can effectively increase the filtration speed and reduce the residual space inside blood.

Description

Cylindrical leukocyte reduction filter with radial flow field and its filtration method Technical Field

[0001] This invention relates to a blood filter, and more particularly to a leukocyte reduction filter, and relates to a blood processing device, specifically a cylindrical leukocyte reduction filter with a radial flow field that utilizes a radial flow path to improve filtration efficiency, reduce blood residue, and shorten processing time. Background Technology

[0002] In the modern medical field, blood processing is a very important and complex technology. In addition, blood is a non-Newtonian fluid, making the design of blood filters even more difficult to improve. Among the current filters, how to effectively reduce white blood cells is an important issue. At present, flat filters are the main type, but they have problems such as limited filtration area, low efficiency, large blood residue, and long filtration time, which urgently need to be solved.

[0003] Referring to Figures 1 and 2 (US Patent Publication No. US20230099894A1), this patent is for a flat plate filter. The filtration method is that the filter membrane passes from one side of the plate to the other side. The blood raw material inlet is located on the side of the plate located slightly above the middle, and the outlet is located on the other side of the plate located slightly below the middle. The disadvantage of this design is that the maximum area of ​​the filter membrane is limited to the area of ​​the plate, and the filtrate is very easy to accumulate at the outlet, resulting in residual liquid.

[0004] Referring to Figures 3 and 4 (US Patent No. US8,857,627B2), this patent also describes a flat-plate filter. The method involves introducing blood into the flat plate from one side, with the inlet located slightly above the center of the plate on the same side. The blood passes through a filter membrane to the other side, generating a primary filtrate. This primary filtrate then undergoes a second filtration through a lower filter membrane to generate a secondary filtrate, which returns to the outlet on the same side as the inlet. However, the outlet is located slightly below the center of the plate on the same side as the inlet to output the secondary filtrate. Similarly, the disadvantages of this design are that the maximum area of ​​the filter membrane is limited to the flat plate area, and due to the outlet design, filtrate easily accumulates at the outlet, resulting in residual liquid.

[0005] Furthermore, the problem with traditional designs lies in the physical limitations of space utilization and filtration efficiency: existing filter designs determine filtration capacity based on "planar area," which presents a non-linear contradiction between volume and area. To improve filtration efficiency, the membrane area must often be increased. However, in a flat structure, increasing the area means that the outer shell diameter must be radially enlarged, resulting in an exceptionally bulky filter. This not only increases packaging, storage, and transportation costs but also occupies the limited operating space of blood processing centers. In addition, since the operation of the filter relies on gravity to allow blood to pass vertically downwards through the filter layer, the internal structure of traditional filters must reserve space for blood entry and exit. Due to gravity, blood tends to accumulate in the lower half of traditional filters, causing the upper membrane to be underutilized. Therefore, within the same volume, the effective filtration path is quite limited, resulting in inefficient space utilization.

[0006] Secondly, blood is a non-Newtonian fluid that is extremely sensitive to shear forces, making blood flow rate control crucial. Excessive flow will damage red blood cells, while insufficient flow can lead to blood clotting. Therefore, blood filters cannot be designed like those used for filtering water or other substances. However, traditional blood filters often suffer from uneven pressure and hemolytic risks due to issues with blood flow control. Uneven pressure creates a centripetal high-pressure phenomenon, meaning that when blood enters the flat chamber, the pressure is highly concentrated in the central region of the filter membrane due to the jet effect at the inlet, resulting in a "high pressure in the center, low pressure at the edges" phenomenon. This uneven filtration speed causes the central filter pores to become clogged prematurely due to prolonged overload. Furthermore, when blood is forced to squeeze through the filter membrane pores under high pressure, the localized high shear force directly damages the red blood cell membrane, leading to hemolytic damage. Traditional structures cannot provide a buffer, and this pressure fluctuation easily causes red blood cell rupture, leading to an increase in free hemoglobin and severely affecting the shelf life and clinical safety of blood products.

[0007] Furthermore, due to the inability of the streamlined design to cover the corners or edges of traditional shell structures, dynamic stagnation dead zones often form. These dead zones not only waste blood but also lead to microclotting and thrombosis during the filtration process. Moreover, for precious donated blood resources, the residual amount in these dead zones, due to the characteristics of traditional shell structures, is one of the main reasons for low blood recovery rates. In some hardware designs, the rigidity of the shell prevents physical expulsion after filtration, resulting in resource waste and causing significant economic losses that the industry urgently needs to address.

[0008] On the other hand, traditional shell structure designs suffer from an "airlock" effect, resulting in incomplete venting due to gas blockage. During the pre-filling stage, existing air easily becomes trapped between the filter membrane surface and the shell, forming microbubbles that aggregate into an air film, obscuring the filtration area and reducing the effective area. This is one of the most difficult problems to overcome in clinical operation of leukocyte reduction filters. Furthermore, when airlock occurs, blood can only pass through unobstructed areas, reducing the effective filtration path and indirectly increasing the load on the effective filter area, increasing the risk of leukocyte penetration and leading to instability in leukocyte reduction. To address the shortcomings caused by residual amounts and airlock, current solutions often involve manually flipping and tapping traditional filters during filtration. However, this easily increases operational variables and raises the potential risk of aseptic packaging damage or contamination.

[0009] Therefore, overcoming the various shortcomings of traditional white blood cell removal filters, such as low space efficiency, uneven pressure distribution, susceptibility to air lock, and high blood residue, in order to achieve optimized blood quality has become a major issue that the industry urgently needs to address. Summary of the Invention

[0010] The purpose of this invention is to provide a cylindrical leukocyte removal filter with a radial flow field, which overcomes the problems of traditional leukocyte removal filters through radial flow field design and exhaust structure.

[0011] This invention provides a cylindrical leukocyte reduction filter with a radial flow field, comprising: a first outer shell, the first outer shell being a cylindrical structure, comprising a first outer shell top wall, a first outer shell annular wall, and a first outer shell opening; wherein the first outer shell top wall further comprises a feed hole for introducing blood raw material, and at least one protruding column is formed on the inner side of the first outer shell annular wall; a diverter for introducing blood raw material and diverting it radially from the diverter to the inner side of the outer perimeter of the first outer shell annular wall, wherein the diverter is tightly fitted to the inner side of the first outer shell top wall. The filter element is a hollow cylindrical structure, and at least one flow channel of the first outer shell annular wall is formed between the outer side of the filter element and the at least one protruding post and the inner side of the first outer shell annular wall to introduce blood raw material from the distributor and filter it through the filter element in a radial flow manner to form filtered blood, and the filtered blood is introduced into the space of the hollow cylindrical structure. The top surface of the filter element is in close contact with the distributor, and the filter element is fitted inside the first outer shell after being combined with the distributor.

[0012] In some embodiments of the present invention, the top wall of the first housing further includes an exhaust device for discharging internal gases.

[0013] In some embodiments of the present invention, the diverter further includes a first diverter component and a second diverter component; the first diverter component further includes a diverter disc component and a diverter radial diverter component; the second diverter component further includes at least one support; the diverter radial diverter component is located on one side of the diverter disc component near the top wall of the first housing; the support is located on the other side of the diverter disc component; the diverter radial diverter component is annular and has scattered holes.

[0014] In some embodiments of this invention, the cylindrical leukocyte reduction filter with radial flow field of the present invention further includes a second housing, which is a cylindrical structure comprising a second housing top wall and a second housing annular wall. The second housing top wall further includes a discharge port for discharging filtered blood, and the bottom surface of the filter element and the second housing annular wall are interlocked and tightly coupled, wherein the first housing annular wall and the second housing annular wall are interlocked and tightly coupled. In the cylindrical leukocyte reduction filter with radial flow field as described in claim 4, the diverter, the hollow cylindrical structure of the filter element, and the inner side of the second housing top wall form a filtered blood receiving space.

[0015] In some embodiments of the present invention, the cylindrical leukocyte reduction filter with radial flow field of the present invention is wherein the first housing and the second housing are one of rigid and flexible types or a combination thereof.

[0016] In some embodiments of the present invention, the cylindrical filter according to the present invention further comprises: a first housing having a cylindrical structure, comprising a first housing top wall, a first housing annular wall, and a first housing opening; wherein the first housing top wall further comprises a feed inlet for introducing blood material; the first housing annular wall further comprises a protruding post; a diverter comprising a diverter first component and a diverter second component; the diverter first component further comprising a diverter disc component and a diverter radial diverter component; the diverter... The second component of the flow divider also includes a support; the radial flow divider component is located on one side of the flow divider disc component near the top wall of the first housing; the support is located on the other side of the flow divider disc component; the radial flow divider component is annular with holes; the filter component is a hollow cylindrical structure; the outer side of the protruding column and the filter membrane layer is a flow channel for forming the annular wall of the first housing; the filter component is tightly fitted to one side of the flow divider disc component; the other side of the filter component and the annular wall of the second housing are interlocked and tightly fitted to the top wall of the second housing.

[0017] In some embodiments of the present invention, the diverter disc component, the filter component, and the inner side of the top wall of the second housing form a blood filtration accommodating space; the diverter and the filter component are combined to be fitted onto the first housing, the first component of the diverter is positioned near the top wall of the first housing and is in close contact with the inner side of the top wall of the first housing; and the annular wall of the first housing and the annular wall of the second housing are fitted together and tightly sealed.

[0018] In some embodiments of the present invention, the top wall of the first housing further includes an exhaust device for discharging internal gases.

[0019] In some embodiments of the present invention, the first housing and the second housing are one of rigid and flexible or a combination thereof.

[0020] In some embodiments of the present invention, the cylindrical leukocyte reduction filter further comprises: a first housing having a cylindrical structure, comprising a first housing top wall, a first housing annular wall, and a first housing opening; the inner side of the first housing being the inner side of the first housing annular wall, wherein a flow channel is provided in the at least one first housing annular wall; the first housing further comprises an exhaust device to facilitate the discharge of internal gas during filtration; a flow divider, wherein a radial flow divider component is disposed on the flow divider, the flow divider further comprising a flow divider disc component and the flow divider radial flow divider component, the flow divider radial flow divider component being positioned... The diverter disc component is located near the top wall of the first housing. A filter component is disposed below the diverter disc component and is located between the flow channel of the at least one annular wall of the first housing and the internal center of the cylindrical leukocyte reduction filter. The radial diverter component is annular and has scattered holes. The filtrate holding space is the internal hollow portion formed by the filter component surrounding the filter component. The second housing has an outlet to facilitate the export of filtered blood from the filtrate holding space, and the top wall of the first housing also includes an inlet to introduce blood raw material into the raw material holding space.

[0021] In some embodiments of the present invention, the first housing and the second housing are one of rigid and flexible or a combination thereof.

[0022] One objective of this invention is to provide a radial flow field filtration path design, comprising a radial diversion component, which allows blood material to flow radially outward from the center and evenly dispersed in the flow channels of the surrounding annular wall. The blood material diffuses radially from the flow channels of the surrounding annular wall towards the center to the filtration component, and is continuously introduced towards the center of the filter in a radial diffusion filtration manner and collected in the filtrate holding space. The aforementioned radial flow field filtration path provides a new flow path structure, allowing blood to flow radially "from the inside out" to the surrounding pipe wall channels, and then diffuse radially "from the outside in" to the filter membrane for filtration. The radial flow field flow path structure of this invention increases the force-bearing area with the radius, thereby optimizing the pressure distribution, making the flow pressure distribution more uniform, avoiding the formation of dynamic stagnation dead zones, and effectively reducing the pressure intensity on the filter membrane, as well as reducing pressure unevenness and pressure fluctuations, thus reducing physical damage to red blood cells (low hemolysis rate). If the radial diversion component of this invention is not used, the flow rate and pressure cannot be controlled, and the blood will naturally tend to flow towards areas of lower pressure.

[0023] Another objective of this invention is to provide an integrated structure for the filtration path, which integrates a radial flow divider, a hollow cylindrical filter element, and a sealed end cap within a cylindrical housing to form a radial flow field filtration path. This radial flow field allows blood samples to uniformly contact the overall surface area of ​​the filter membrane, thereby maximizing the usable filtration area, significantly reducing internal dead zones, lowering residue levels, and improving red blood cell recovery. Furthermore, within the same volume, the annular structure provides a larger filtration surface area than the conventional flat structure, significantly shortening the filtration time.

[0024] Another objective of the present invention is to provide an exhaust device so as to effectively expel the air present during the pre-filling stage, thereby maintaining an effective filtration area, avoiding the "airlock" effect that reduces the effective filtration path, preventing leukocyte penetration, and mitigating the risks of human error.

[0025] Another objective of this invention is that the cylindrical structure of this invention, due to the larger surface area of ​​the outer perimeter of the filter membrane than the inner perimeter, provides the largest initial filtration contact surface for the radial filtration method "from the outside in," thereby maximizing the filtration surface area. The larger filtration surface area effectively reduces the white blood cell aggregation density on the filter membrane surface, thus reducing filtration resistance, and is particularly effective for processing blood products with high concentrations of white blood cells. Furthermore, this invention provides an exhaust mechanism at the top of the outer shell, near the highest point of the outer annular distribution channel. When the blood material initially enters the annular distribution channel (i.e., the channel around the perimeter walls), the air inside is compressed upwards and discharged through this exhaust mechanism until the blood material completely fills the channel. This delays blockage, eliminates airlock, and ensures that the outer perimeter surface area of ​​the filter membrane is completely wetted by the blood material in the initial stage of the filtration process, avoiding a reduction in filtration area due to air accumulation.

[0026] According to the above-described technical solution of the present invention, the function of the present invention is as follows: When the blood raw material is introduced into the filter, it is first guided from the center outward by the radial diversion component to the outer annular distribution channel (i.e., the surrounding pipe wall channel) between the inner wall of the outer shell and the outer periphery of the filter membrane. Then, after the blood raw material is compressed, it diffuses radially from the surrounding pipe wall channel "from the outside in" to the surface of the filter membrane, and is continuously filtered (centripetal flow) from the outer periphery of the filter membrane towards the center of the filter. The filtered blood is collected in the central hollow manifold (i.e., the filtrate holding space) and finally flows downward.

[0027] The present invention also provides a blood filtration method for removing white blood cells by means of a cylindrical filter, comprising: blood raw material flowing from the inside to the outside of the raw material receiving space in all directions to the annular wall of the first outer shell by means of a radial diversion component of a diverter, and flowing downward along the flow channel from the protruding column to the annular wall of the first outer shell; and the blood raw material filling the flow channel of the annular wall of the first outer shell and diffusing to the outside of the filter component, while the pressure difference between the inside and outside of the filter component forms a radial flow in all directions from the outside to the inside, filtering the blood raw material to form filtered blood, and introducing and collecting it in the filtrate receiving space.

[0028] In some embodiments of this invention, the blood filtration method for leukocyte reduction using a cylindrical filter further includes: introducing blood raw material through an inlet port into a raw material receiving space between the top wall of the first housing and the first component of the distributor; the filtered blood flowing from the filtrate receiving space to the top wall of the second housing and being discharged through an outlet port. The blood filtration method for leukocyte reduction using a cylindrical filter further includes: venting pre-existing air by means of an exhaust device when the blood raw material fills the flow channel of the annular wall of the first housing.

[0029] The present invention also provides a blood filtration method for leukocyte reduction, comprising: providing a cylindrical leukocyte reduction filter, the cylindrical leukocyte reduction filter including a raw material receiving space located at the top of the cylindrical leukocyte reduction filter to receive blood raw material, at least one flow channel of a first outer shell annular wall surrounding the raw material receiving space, and a filter element disposed around the inner center of the cylindrical leukocyte reduction filter; the internal hollow portion formed by the filter element around the center of the cylindrical leukocyte reduction filter is a filtrate receiving space; and the blood raw material is radially diverted from the raw material receiving space by a flow divider radially diverting component. The blood material flows radially into the flow channels of at least one first outer shell annular wall and is introduced into the flow channels of the at least one first outer shell annular wall; the blood material is introduced into the filter element in a radially diffused manner from the flow channels of the at least one first outer shell annular wall, and the blood material is filtered and white blood cells are removed by the filter element to form filtered blood; the filtered blood is introduced into the inner center in a radial manner and collects in the filtrate containing space; the second shell is provided with an outlet to facilitate the export of the filtered blood from the filtrate containing space, and the top wall of the first shell also includes an inlet to introduce the blood material into the material containing space. Attached Figure Description

[0030] Figure 1 is a schematic diagram of one of the existing technologies, a wide planar diagram.

[0031] Figure 2 is a schematic diagram of one of the existing technologies with a narrow face.

[0032] Figure 3 is a schematic diagram of one of the existing technologies, a wide planar diagram.

[0033] Figure 4 is a schematic diagram of one of the existing technologies with a narrow face.

[0034] Figure 5 is a perspective view of a cross-section along the longitudinal direction of one of the present inventions.

[0035] Figure 6 is a perspective view of a cross-section along the longitudinal direction of one of the present inventions.

[0036] Figure 7 is a plan view of one of the flow divider and filter membrane and their combination according to the present invention.

[0037] Figure 8 is a plan view of one of the following: the diverter, the filter membrane, the second housing, and a combination thereof, according to the present invention.

[0038] Figure 9 is a plan view of one of the first housing, the diverter, the filter membrane, and the second housing and combinations thereof of the present invention.

[0039] Figure 10 is a cross-sectional schematic diagram of one of the first outer shell and the top wall of the first outer shell of the upper cover component of the present invention.

[0040] Figure 11 is a schematic diagram of liquid flow according to an embodiment of the present invention.

[0041] Figure 12 is a flowchart of a method according to an embodiment of the present invention.

[0042] Reference numerals: 1000: Cylindrical leukocyte reduction filter with radial flow field; 1100: First outer shell; 1110: Top wall of first outer shell; 1111: Feed port; 1112: Exhaust device; 1120: Annular wall of first outer shell; 1121: Protruding column; 1122: Flow channel of annular wall of first outer shell; 1123: Raw material holding space; 1130: Opening of first outer shell; 1200: Diverter; 1210: First component of diverter; 1211: Disc component of diverter; 1212: Radial diverting component of diverter; 1220: Second component of diverter; 1221: Support; 1300: Filtering component; 1310: Filtrate holding space; 1400: Second outer shell; 1410: Top wall of second outer shell; 1411: Discharge port; 1420: Annular wall of second outer shell.

[0043] 1700: Blood filtration method using the filter of the present invention

[0044] 1710: Step: Introduce blood raw material through the feed port 1111 and into the raw material receiving space 1123 between the top wall 1110 of the first outer shell and the first component 1210 of the distributor.

[0045] 1720: Step: Blood raw material flows radially from the inside to the outside of the raw material receiving space through the radial diversion component 1212 of the diverter, flowing in a 360-degree omnidirectional manner towards the first outer shell annular wall 1120, and flows downward along the flow channel 1122 from the protruding column 1121 to the first outer shell annular wall.

[0046] 1730: Step: Blood raw material fills the flow channel 1122 of the first outer shell annular wall and diffuses to the outside of the filter element 1300. At the same time, due to the pressure difference between the inside and outside of the filter element 1300, a radial flow is formed in all 360 degrees from the outside to the inside, filtering the blood raw material to form filtered blood, which is then introduced and collected in the filtrate receiving space 1310.

[0047] 1731: Step: When the blood material fills the flow channel 1122 of the first outer shell annular wall, the existing air is discharged through the air hole 1112 and the air hole valve 1113.

[0048] 1740: Step: Filtered blood flows from the filtrate container 1310 to the top wall 1410 of the second outer casing and is discharged through the discharge port. Detailed Implementation

[0049] This invention focuses on a cylindrical leukocyte reduction filter with a radial flow field and its filtration method. To ensure a thorough understanding of the invention, detailed structures, components, and method steps will be presented in the following description. Clearly, the implementation of this invention is not limited to the specific details familiar to those skilled in the art. Furthermore, well-known structures and components are not described in detail to avoid unnecessary limitation of the invention. In addition, to provide a clearer description and enable those skilled in the art to understand the invention, the parts in the illustrations are not drawn according to their relative dimensions; some dimensions are exaggerated to highlight their proportions to other related dimensions, and irrelevant details are not fully drawn for the sake of simplicity. Preferred embodiments of the invention will be described in detail below; however, in addition to these detailed descriptions, the invention can be widely implemented in other embodiments, and its scope is not limited by the claims.

[0050] Referring to Figures 5 to 12, according to an embodiment of the present invention, a cylindrical leukocyte reduction filter 1000 with a radial flow field is provided, comprising a first housing 1100, a flow divider 1200, a filter element 1300, and a second housing 1400. The first housing 1100 has a cylindrical structure, comprising a first housing top wall 1110, a first housing annular wall 1120, and a first housing opening 1130. The first housing top wall 1110 further includes a feed inlet 1111 and an exhaust device 1112. The feed inlet 1111 is located at the center of the first housing top wall 1110. At least one protruding post 1121 is formed inside the first housing annular wall 1120. The feed inlet 1111 is for introducing blood raw materials, and the exhaust device 1112 is for discharging internal gases, and the exhaust device 1112 has a check valve structure.

[0051] A diverter 1200 comprises a first diverter component 1210 and a second diverter component 1220. The first diverter component 1210 further comprises a diverter disc component 1211 and a diverter radial diverter component 1212. The second diverter component 1220 further comprises at least one support 1221. The radial diverter component 1212 is positioned on one side of the diverter disc component 1211 near the top wall of the first housing. The support 1221 is positioned on the other side of the diverter disc component 1211. The radial diverter component 1212 is annular and has scattered holes. A raw material receiving space 1123 is formed between the top wall 1110 of the first housing and the first diverter component 1210. The outer side of the protruding post 1121 and the filter membrane layer 1310 forms a flow channel 1122 for forming the annular wall of the first housing.

[0052] The filter element 1300 is a hollow cylindrical structure.

[0053] The second outer casing 1400 has a cylindrical structure, comprising a top wall 1410 and an annular wall 1420. The top wall 1410 includes a discharge port 1411 for discharging filtered blood. The second component 1221 of the diverter and the filter component 1300 are interlocked, with the filter component 1300 tightly fitted to one side of the diverter disc component 1211. The other side of the filter component 1300 is interlocked and tightly fitted to the annular wall 1420 of the second outer casing. The diverter disc component 1211, the filter component 1300, and the inner side of the top wall 1410 of the second outer casing form a filtrate receiving space 1310. After the diverter 1200 and the filter component 1300 are combined, they are fitted onto the first housing 1100. The first component 1210 of the diverter is positioned on the side close to the top wall 1110 of the first housing, and the radial diverter component 1212 is in close contact with the inner side of the top wall 1110 of the first housing. The annular wall 1120 of the first housing and the annular wall 1420 of the second housing are fitted together and tightly sealed.

[0054] Referring to Figures 5 to 12, a blood filtration method 1700 for white blood cell removal using a cylindrical filter includes the following steps: introducing blood raw material through the feed port 1111 and entering the raw material receiving space 1123 between the top wall 1110 of the first housing and the first component 1210 of the diverter (step 1710); the blood raw material flows from the inside to the outside of the raw material receiving space in a 360-degree omnidirectional manner (radial flow) through the radial diversion component 1212 of the diverter to the annular wall 1120 of the first housing, and flows along at least one protruding post 1121 to the annular wall 1120 of the first housing. The blood flows downward through the flow channel 1122 of the first outer shell (step 1720). The blood material fills the flow channel 1122 of the first outer shell annular wall and diffuses to the outside of the filter component 1300. At the same time, due to the pressure difference between the inside and outside of the filter component 1300, a radial flow is formed in all 360 degrees from the outside to the inside to filter the blood material and form filtered blood. The filtered blood is then introduced and collected in the filtrate holding space 1310 (step 1730). The filtered blood is guided from the filtrate holding space 1310 to the top wall 1410 of the second outer shell and discharged through the discharge hole (step 1740). During the process of the blood material filling the flow channel 1122 of the first outer shell annular wall, the existing air can be discharged by the exhaust device 1112 (step 1731).

[0055] Referring to Figures 5 to 12, according to the above embodiments, the present invention proposes a blood filtration method for leukocyte reduction, comprising: providing a cylindrical leukocyte reduction filter, the cylindrical leukocyte reduction filter comprising a raw material containing space located at the top of the cylindrical leukocyte reduction filter to contain blood raw material, at least one flow channel located around the raw material containing space, a filter element disposed around the inner center of the cylindrical leukocyte reduction filter, and an inner hollow portion formed by the filter element surrounding the center of the cylindrical leukocyte reduction filter as a filtrate containing space; the blood raw material is radially flowed from the raw material containing space to the at least one flow channel on the outer periphery by a radial flow divider and introduced into the at least one flow channel; the blood raw material diffuses radially inward from the at least one flow channel to the filter element, and the blood raw material is filtered and leukocytes are removed by the filter element to form filtered blood; and the filtered blood is introduced into the inner center in a radial flow manner and collected in the filtrate containing space.

[0056] The aforementioned blood filtration method for leukopenia, wherein the cylindrical leukopenia filter further comprises: a first housing, the inner side of which is the inner side of the annular wall of the first housing, wherein at least one flow channel is disposed; a diverter, wherein a radial diverting component is disposed on the diverter, the diverter further comprising a diverter disc component and the diverter radial diverting component, the diverter radial diverting component being disposed on the diverter disc component and near the top wall of the first housing, the diverter radial diverting component being annular and having scattered holes, wherein the filter component is disposed and surrounds the diverter disc component below, and is located at the at least one The flow channel is between the inner center of the cylindrical leukocyte removal filter; the filtrate holding space is the hollow inner portion formed by the filter element surrounding the center of the cylindrical leukocyte removal filter; the first shell and the second shell are one of rigid and flexible types or a combination thereof; the top wall of the first shell also includes an exhaust device to facilitate the discharge of internal gas during the filtration process; the bottom of the cylindrical leukocyte removal filter also includes a second shell, the second shell being provided with an outlet to facilitate the export of filtered blood from the filtrate holding space, and the top wall of the first shell also includes an inlet to introduce blood raw material into the raw material holding space.

[0057] The following are tests comparing the present invention with conventional filters.

[0058] Traditional filter test results

[0059] Filter test results of this invention

[0060] Comparing the two tables above, it can be seen that the average filtration time of the present invention is 13 minutes and 45 seconds, and the average blood residue is 30.00g, while the average filtration time of the existing filter is 18 minutes and 32 seconds, and the average blood residue is 32.78g. Clearly, the present invention has a faster filtration speed than the traditional filter, reducing the filtration time by 25.81%; and the present invention reduces the blood residue by 8.48% compared to the traditional filter.

[0061] Furthermore, the above examples include sequential exemplary steps, but these steps need not be performed in the order shown. Performing these steps in different orders is within the scope of this invention. Within the spirit and scope of the embodiments of this invention, these steps may be added, substituted, changed in order, and / or omitted as appropriate.

[0062] Although the present invention has been disclosed above with reference to embodiments, it is not intended to limit the scope of the invention. Any person skilled in the art can make various modifications and refinements without departing from the spirit and scope of the invention. Therefore, the scope of protection of the present invention shall be determined by the claims.

Claims

1. A cylindrical leukocyte reduction filter with radial flow field, characterized in that, It includes: The first outer shell is a cylindrical structure, comprising a first outer shell top wall, a first outer shell annular wall, and a first outer shell opening; wherein the first outer shell top wall further comprises a feed hole for introducing blood raw materials, and at least one protruding post is formed on the inner side of the first outer shell annular wall; A flow divider is used to introduce blood raw materials and to direct them radially from the flow divider to the inner side of the annular wall of the first outer casing, wherein the flow divider is in close contact with the inner side of the top wall of the first outer casing; and The filter component is a hollow cylindrical structure, and at least one flow channel of the first outer shell annular wall is formed between the outer side of the filter component and the at least one protruding column and the inner side of the first outer shell annular wall to introduce blood raw material from the distributor, and filter it through the filter component in a radial flow manner to form filtered blood, and introduce the filtered blood into the space of the hollow cylindrical structure. The top surface of the filter component is in close contact with the distributor, and the filter component, after being combined with the distributor, is fitted inside the first outer shell.

2. The cylindrical leukocyte reduction filter with radial flow field according to claim 1, characterized in that, The top wall of the first housing also includes an exhaust device for discharging internal gases, wherein the exhaust device has a check valve structure.

3. The cylindrical leukocyte reduction filter with radial flow field according to claim 1, characterized in that, The diverter further includes a first diverter component and a second diverter component; the first diverter component further includes a diverter disc component and a diverter radial diverter component; the second diverter component further includes at least one support; the diverter radial diverter component is located on one side of the diverter disc component near the top wall of the first housing; the support is located on the other side of the diverter disc component; the diverter radial diverter component is annular and has scattered holes.

4. The cylindrical leukocyte reduction filter with radial flow field according to claim 1, characterized in that, It also includes a second outer shell, which is a cylindrical structure, comprising a top wall and an annular wall. The top wall of the second outer shell also includes a discharge hole for discharging filtered blood. The bottom surface of the filter component and the annular wall of the second outer shell are interlocked and tightly connected. The annular wall of the first outer shell and the annular wall of the second outer shell are interlocked and tightly connected.

5. The cylindrical leukocyte reduction filter with radial flow field according to claim 4, characterized in that, The hollow cylindrical structure of the diverter and the filter component forms a blood filtration and containment space with the inner side of the top wall of the second outer shell.

6. The cylindrical leukocyte reduction filter with radial flow field according to claim 4, characterized in that, The first housing and the second housing are one of rigid and flexible or a combination thereof.

7. A blood filtration method for reducing white blood cells using a cylindrical filter, characterized in that, It includes: Blood raw materials flow from the inside to the outside of the raw material receiving space in all directions through the radial diversion component of the diverter, and flow downward along the flow channel from the protruding column to the annular wall of the first outer shell. as well as Blood material fills the flow channel of the first outer shell annular wall and diffuses to the outside of the filter element. At the same time, the pressure difference between the inside and outside of the filter element forms a radial flow from the outside to the inside, filtering the blood material to form filtered blood, which is then introduced and collected in the filtrate container space.

8. The blood filtration method for white blood cell reduction by means of a cylindrical filter according to claim 7, characterized in that, It also includes: introducing blood raw material through the feed port and entering the raw material receiving space between the top wall of the first housing and the first component of the diverter; the filtered blood is guided from the filtrate receiving space to the top wall of the second housing and discharged through the discharge port.

9. The blood filtration method for white blood cell reduction by means of a cylindrical filter according to claim 7, characterized in that, It also includes: during the process of the blood material filling the flow channel of the first outer shell annular wall, the existing air is discharged by means of an exhaust device.

10. The blood filtration method for white blood cell reduction by means of a cylindrical filter according to claim 7, characterized in that, The cylindrical filter also includes: The first outer shell has a cylindrical structure and includes a top wall, an annular wall, and an opening. The top wall further includes a feed inlet for introducing blood material. The annular wall also includes a protruding post. The diverter comprises a first diverter component and a second diverter component; the first diverter component further comprises a diverter disc component and a diverter radial diverter component; the second diverter component further comprises a support; the diverter radial diverter component is positioned on one side of the diverter disc component near the top wall of the first housing; the support is positioned on the other side of the diverter disc component; the diverter radial diverter component is annular with holes. The filter element is a hollow cylindrical structure; the outer side of the protruding column and the filter membrane layer is a flow channel for forming the first outer shell annular wall; The second outer shell is a cylindrical structure comprising a top wall and an annular wall; wherein the top wall includes a discharge port for discharging filtered blood. The filter component is tightly fitted to one side of the distributor disc component; The other side of the filter component is interlocked with the annular wall of the second housing and is tightly fitted to the top wall of the second housing. The diverter disc component, the filter component and the inner side of the top wall of the second housing form a blood filtration and accommodating space. The diverter, when combined with the filter component, is fitted inside the first housing. The first component of the diverter is positioned near the top wall of the first housing and is in close contact with the inner side of the top wall of the first housing. The first outer shell annular wall and the second outer shell annular wall are interlocked and tightly fitted together.

11. The blood filtration method for white blood cell reduction by means of a cylindrical filter according to claim 10, characterized in that, The top wall of the first housing also includes an exhaust device to expel internal gases.

12. The blood filtration method for white blood cell reduction by means of a cylindrical filter according to claim 10, characterized in that, The first housing and the second housing are either rigid or flexible, or a combination thereof.

13. A blood filtration method for leukopenia, characterized in that, It includes: A cylindrical leukocyte reduction filter is provided, comprising a raw material holding space located at the top of the cylindrical leukocyte reduction filter to hold blood raw material, at least one flow channel of a first outer shell annular wall surrounding the raw material holding space, and filter components arranged around the internal center of the cylindrical leukocyte reduction filter; the internal hollow portion formed by the filter components surrounding the center of the cylindrical leukocyte reduction filter serves as a filtrate holding space; The blood raw material is radially flowed from the raw material accommodating space to the flow channels of at least one first outer shell annular wall around the outside via the radial flow component of the flow divider and is introduced into the flow channels of the at least one first outer shell annular wall. Blood raw material diffuses radially inward from the flow channel of at least one first outer shell annular wall to the filter element, and at the same time, the blood raw material is filtered and white blood cells are removed by the filter element to form filtered blood; as well as The filtered blood is introduced into the inner center in a radial flow manner and collected in the filtrate container space; A second housing is provided with an outlet to facilitate the export of the filtered blood from the filtrate container space, and the top wall of the first housing also includes an inlet to introduce blood raw materials into the raw material container space.

14. The blood filtration method for leukopenia according to claim 13, characterized in that, The cylindrical leukocyte reduction filter also includes: A first outer casing, wherein at least one flow channel of the first outer casing annular wall is provided on the inner side of the first outer casing annular wall; the first outer casing also includes an exhaust device to facilitate the discharge of internal gas during the filtration process; A diverter, wherein the radial diverting component of the diverter is disposed on the diverter, the diverter further comprising a diverter disc component and the radial diverting component, the radial diverting component being disposed on the side of the diverter disc component near the top wall of the first housing, wherein a filter component is disposed and surrounds the diverter disc component below, and is located between the flow channel of the at least one annular wall of the first housing and the internal center of the cylindrical leukocyte reduction filter; the radial diverting component is annular and has scattered holes; and The filtrate containing space is the hollow internal portion formed by the filter element surrounding the filter element; and The second housing has an outlet for exporting the filtered blood from the filtrate container space, and the top wall of the first housing also includes an inlet for introducing blood raw materials into the raw material container space.

15. The blood filtration method for leukopenia according to claim 14, characterized in that, The first housing and the second housing are one of rigid and flexible or a combination thereof.

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