Steroid compound, pharmaceutical composition thereof, and use thereof

By developing a compound with a specific structure to inhibit the SREBP pathway, the treatment challenges of metabolic diseases such as fatty liver have been solved, achieving the effect of reducing liver triglycerides and cholesterol, and providing a new drug for the treatment of fatty liver.

WO2026158654A1PCT designated stage Publication Date: 2026-07-30CHOLESGEN (SHANGHAI) CO LTD
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
CHOLESGEN (SHANGHAI) CO LTD
Filing Date
2026-01-26
Publication Date
2026-07-30

AI Technical Summary

Technical Problem

Currently, there are no effective drugs for treating fatty liver disease, especially inhibitors targeting the SREBP pathway, which cannot effectively reduce liver triglyceride and cholesterol levels, leading to the occurrence and development of metabolic diseases such as fatty liver.

Method used

A novel compound or a pharmaceutically acceptable salt thereof is provided that reduces hepatic triglyceride and cholesterol levels by inhibiting the SREBP pathway, specifically represented by Formula I-0 and Formula I, containing specific carbon atom linkages and substituents that can bind to the SREBP protein and block its activation.

Benefits of technology

Effectively inhibiting the SREBP pathway, reducing liver triglyceride and cholesterol levels, and preventing and treating metabolic diseases such as fatty liver provide a new treatment strategy.

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Abstract

Disclosed are a steroid compound, a pharmaceutical composition thereof, and use thereof. Specifically disclosed is a compound represented by formula I-0 or a pharmaceutically acceptable salt thereof. The compound of the present invention has SREBP pathway inhibitory activity, and can be used for preventing and / or treating diseases such as obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, and skin damage.
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