Stable synergistic pesticidal composition and process thereof

Abstract

The present invention relates to stable synergistic pesticidal composition for synergistic and effective control of various pests including but not limited to insect-pests, sucking pests complex. The present invention also relates to a method for preparing stable synergistic pesticidal composition for synergistic and effective control of various pests including but not limited to insect-pests, sucking pests complex and the process for the preparation thereof.

Description

[0001] STABLE SYNERGISTIC PESTICIDAL COMPOSITION AND PROCESS THEREOF FIELD OF THE INVENTION

[0002] The present invention relates to the field of agrochemical compositions. Particularly, the present invention relates to a stable synergistic pesticidal composition comprising A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives for effective control of various pests including but not limited to insects, sucking pests, etc. and wide range of diseases caused by such pests. Further, the present invention also relates to a process for preparation of such pesticidal composition for synergistic and efficacious control of various pests including insects-pests.

[0003] BACKGROUND OF THE INVENTION

[0004] Conventional pesticidal formulations have been improved to achieve effective control of pests including but not limited to insects, sucking pests, etc. while ensuring improved crop yield, ease of application, storage stability. However, prolonged and repeated use of single-active or conventional pesticidal formulations has resulted in several limitations, including the development of resistance in insect-pest populations, reduced field efficacy, phytotoxic effects on crops, and undesirable environmental impact.

[0005] Insect-pest resistance has emerged as a major challenge in modern agriculture, significantly reducing the effectiveness of many commercially available pesticidal products. Sucking pests such as thrips, whiteflies, aphids, leafhoppers, and related complexes are particularly difficult to control due to their rapid reproduction, multiple life stages, and ability to develop resistance to commonly used insecticides. As a result, repeated applications at higher doses are often required, leading to increased production costs and environmental burden. Further, several known pesticidal compositions suffer from limitations such as slow onset of action, reduced residual activity, limited spectrum of control, and adverse effects on crop foliage, including discoloration, phytotoxicity, and growth suppression. Certain compositions are also ineffective in controlling all life stages of insect pests and may adversely affect non-target organisms, thereby raising concerns regarding environmental sustainability.Various prior arts in pesticidal compositions are tailored based on the active ingredients are used along with their intended applications. However, existing pesticidal combinations exhibit adverse effect on plants and crops such as discoloration of plant leaves, resistance against sucking pests complex and are ineffective against control of all stages of sucking pests complex such as jassids, thrips, white fly, aphids etc.

[0006] References can be made to CN107593723A, which discloses a composition comprising active ingredients A and B, wherein A is fluxametamide and B can be selected from chlorfenapyr, diclofenac, chlorpheniridine, GF-2877, spiropidion, kappa-bifenthrin, kappa - One or more combinations of tefluthrin, cyanocaveri, fluconazolamide, flucarbazone, mefentrifluconazole, ipfentriflnconazole, dipymetitrone, fenpicoxamid, aminopyrifen, inpyrfluxam, and titration amide.

[0007] Further CN103053586A also discloses a synergistic insecticidal composition containing dinotefuran and thiamethoxam, and an application thereof 0.1-70:0.2-70.

[0008] In view of the limitations associated with single-active pesticidal formulations, including reduced efficacy and the development of resistance in insect-pest & sucking pests populations, it has been recognized that combining active ingredients having distinct and complementary modes of action can provide improved pest control. Fluxametamide and Dinotefuran act on different target sites within insect physiology and are effective against overlapping as well as complementary spectra of insect pests such as sucking pests. The combination of these two active ingredients enables enhanced and consistent control across multiple life stages of pests while reducing reliance on repeated applications of a single mode of action. Further, when formulated together in specific weight ratios, Fluxametamide and Dinotefuran exhibit mutual compatibility and formulation stability, thereby providing a pesticidal composition that delivers improved field performance, resistance management, and crop safety compared to individual application of the actives.

[0009] Further there is need to develop a stable synergistic pesticidal composition showing an enhanced efficacy, reduced likelihood of resistance development, reduced toxicity, increased residual activity, reduced dosages, broader crop protection, improved and healthy foliage, improved crop yield, saves labour, mitigate environmental impact and economical and is yet cost effective to the end user.Therefore, the aim of the present invention is to provide a stable synergistic pesticidal composition that addresses these needs by providing a stable synergistic pesticidal composition that combines active ingredients and that too in specific weight percentage ranges. Composition of present invention has demonstrated superior efficacy in controlling a broad spectrum of pests while being environmentally sustainable.

[0010] The present disclosure is a solution to the aforementioned problems and provides a stable synergistic pesticidal composition including A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0011] After thorough research and development, the inventor of this invention has effectively merged pesticidal compounds to formulate a new pesticidal composition having synergistic effects and significantly improved effectiveness.

[0012] Fluxametamide is isoxazoline class of insecticide belongs to the amide class of insecticides effective against a broad spectrum of pests. Fluxametamide is a racemate comprising equimolar amounts of (R)- and (S)-fluxametamide. It pertains to a ligand-gated chloride channel (LGCC) antagonist action ultimately leading to paralysis and death. It is used in pest management strategies along with offering an additional mode of action, which is vital for managing resistance in pest populations that have become accustomed to conventional insecticides. It is effective against a broad spectrum of pest such as houseflies, spider mite, leafhoppers, etc in crops such as strawberries, aubergine, tea, etc.

[0013] Dinotefuran is a neonicotinoid insecticide used to control a wide range of sucking pests. It pertains to nicotinic acetylcholine receptors (nAChRs) channel blocker in the central nervous system of insects. It is effective against whiteflies, jassids, mealybugs, thrips, plant hoppers, leaf miners, aphids, etc. and can be applied in wide range of crops such as vegetables, fruit, turf, rice crops, etc.

[0014] The present invention satisfies the existing needs, as well as others, and generally overcomes the deficiencies found in the prior art. The pesticidal composition of the present invention is synergistic, efficacious, environmentally friendly, cost-effective, simple to formulate, stable and is safe and easy to use.Thus, a stable synergistic pesticidal composition of the present invention aims to overcome the problems of the prior art and provides a stable synergistic pesticidal composition comprising bioactive amounts of comprising pesticidal composition comprising A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives for synergistic and effective control of various pests including but insect-pests.

[0015] Present invention also discloses a method for preparing a stable synergistic pesticidal composition of the present invention comprising A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives for synergistic and effective control of various pests including but not limited to insect-pests & sucking pests complex, etc.

[0016] OBJECTIVES AND ADVANTAGES OF THE INVENTION

[0017] The main objective of the present invention is to provide a novel and effective stable synergistic pesticidal composition exhibiting enhanced efficacy and stability for broad spectrum of pests, including but not limited to insect-pests, sucking pests such as white flies, jassids, thrips etc. affecting crops and plants.

[0018] Another objective of the present invention is to provide a ready-to-use and stable pesticidal composition that delivers improved pest control performance as compared to individual active ingredients or conventional or existing pesticidal formulations.

[0019] Yet another objective of the present invention is to facilitate effective pest management by developing an advanced broad- spectrum pesticidal combination. Another objective of the present invention is to provide selective effectiveness while significantly reducing adverse effects on nontarget organisms, particularly beneficial species, thus promoting ecological balance.

[0020] Yet another objective of the present invention to provide a novel and effective stable synergistic pesticidal composition effectively targeting all life stages of major plant pathogens and promoting overall plant health and crop yield.It is yet another objective of the present invention to provide a method and a stable synergistic pesticidal composition for controlling insect.

[0021] Yet another objective of the present invention is to provide a composition and method for controlling various pests including sucking pests in plants, crops and plant propagation materials.

[0022] Another objective of the present invention is to provide one shot application of novel and effective stable synergistic pesticidal composition for killing / controlling highly resistant pests at lower application rates.

[0023] It is another objective of the present invention to provide a novel and effective stable synergistic pesticidal composition which is environmentally safe, possesses broad spectrum bio-efficacy, is non-phytotoxic and has improved stability during the desired shelf life at various temperature and pH conditions and has enhanced efficacy and penetration capacity and is economically more beneficial.

[0024] It is another objective of the present invention to provide a novel and effective stable synergistic pesticidal composition which further comprises additives, inert ingredients and / or adjuvants, for providing the enhanced stability, enhanced permeability, improved penetration capacity, uniform spray-ability, improved rain-fastness, enriched biotic factors, better flowability, enhanced spreading or coverage effect, effective storage stability, longer residual effect, improved uptake of active ingredients, and safer to the environment attributes to the composition of present invention.

[0025] It is another objective of the present invention is to provide a stable synergistic pesticidal composition that protects crop and the environmental damage.

[0026] Another main objective of the present invention is to provide a novel and effective stable synergistic pesticidal composition that is environmentally safe, exhibits broad-spectrum bioefficacy, is non-phytotoxic, and maintains improved stability throughout its intended shelf life across various temperature and pH conditions, while also enhancing efficacy, penetration capacity, and economic viability.Yet another objective of present invention is to provide a stable synergistic pesticidal composition that improves plants stand count and plant health, which results in higher yield.

[0027] Another objective of the present invention is to provide a stable synergistic pesticidal composition comprising A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0028] Yet another objective of the present invention is to provide a process for the preparation of a stable synergistic pesticidal composition comprising A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0029] Some or all these and other objects of the invention can be achieved by way of the invention described hereinafter.

[0030] ADVANTAGES:

[0031] 1. The stable synergistic pesticidal composition is effective in protecting a wide range of crops, including fruits, vegetables, cereals, ornaments, flowers and seeds against major plant diseases including foliar, stem and root diseases and shows no phytotoxicity effect and provide a stable synergistic pesticidal composition that shows technical advancement over the existing combination of pesticides and also proves to has an improved rain fastness.

[0032] 2. The stable synergistic pesticidal composition ensures better control of plant / crop in a shorter period of time and shows to have decrease chances of resistance against pesticidal diseases and shows to have an improved stability during the desired shelf life and promotes plant health and increases plant yield in the field.

[0033] 3. The stable synergistic pesticidal composition lower cost of application and ensure better cost-benefit ratio to the end user.

[0034] 4. The stable synergistic pesticidal composition of the present invention results in significant effective control against various pests including but not limited to insects-pests, sucking pests, leaf hopper, thrips, fruit and shoot borer, Diamond back moth, tobacco caterpillar,semi looper, spotted pod borer, pod borer, thrips, brown plant hopper, whitefly, jassids, aphids, leaf hopper, white backed plant hopper and green leaf hopper, houseflies, spider mite, leafhoppers, mealybugs, plant hoppers, leaf miners, etc.

[0035] 5. The stable synergistic pesticidal composition can be applied to various crops and plants including but not limited to brinjal, cabbage, chilli, okra, red gram, tomato, rice (paddy), cotton, rice, strawberries, aubergine, tea, vegetables, fruit, turf; etc.

[0036] SUMMARY OF THE INVENTION

[0037] Accordingly, the main aspect of the present invention is to provide a stable synergistic pesticidal composition having high pests control efficacy.

[0038] Accordingly, the present invention relates to a stable synergistic pesticidal composition comprising:

[0039] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0040] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivative.

[0041] In another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0042] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0043] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0044] C) One or more agrochemically acceptable excipients.

[0045] In another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0046] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0047] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0048] C) At least one or more additive.In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0049] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0050] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives;

[0051] C) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof; and

[0052] D) One or more agrochemically acceptable excipients.

[0053] In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0054] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0055] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition.

[0056] In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0057] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0058] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0059] C) One or more agrochemically acceptable excipients.

[0060] In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0061] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0062] C) At least one or more additive.

[0063] In yet another aspect, the present invention provides a process for preparation of the stable synergistic pesticidal composition comprising:

[0064] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0065] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0066] In an aspect of the present invention, the present invention provides a stable synergistic pesticidal composition which further comprises additives for providing the following attributes to the composition of present invention:

[0067] a) enhanced stability, permeability and spreading or coverage effect,

[0068] b) improved rain-fastness,

[0069] c) improved penetration capacity, uniform spray-ability, storage stability,

[0070] d) longer residual effect and better flowability

[0071] e) enriched biotic factors,

[0072] f) improved uptake of active ingredients, and safer to the environment.

[0073] In another aspect, the present synergistic pesticidal composition is stable and has enhanced shelf life and effectively control wide range of pests including insects-pests, sucking pests in various crops. In another aspect, the present invention provides a stable synergistic pesticidal composition which has enhanced efficacy and penetration capacity.

[0074] DETAILED DESCRIPTION OF THE INVENTION

[0075] In describing the embodiments of the invention, specific terminology is resorted for sake of clarity. However, it is not intended that the invention be limited to specific terms so selected and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, suitable methods and materials are described herein.

[0076] Unless otherwise stated, and as discussed further below, the term isomers as used herein refers to but not limited to enantiomers of chiral compound or a mixture thereof.

[0077] Discussed below are some representative embodiments of the present invention. The invention in its broader aspects is not limited to the specific details and representative methods.

[0078] All technical and scientific terms used herein have the same meanings as commonly understood by someone ordinarily skilled in the art to which the present subject matter belongs.

[0079] The terminology used, in the present disclosure, is only for the purpose of explaining a particular embodiment and such terminology shall not be considered to limit the scope of the present disclosure.

[0080] As used in the present disclosure, the forms "a,” "an," and "the" may be intended to include the plural forms as well, unless the context clearly suggests otherwise. Thus, for example, reference to a composition containing “a compound” includes a one or two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and / or” unless the content clearly dictates otherwise.

[0081] The terms "comprises / comprises", "comprising", “including”, and “having” are open ended transitional phrases and therefore specify the presence of stated features, integers, steps, operations, elements, but do not forbid the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. The particular order of steps disclosed in the method and process of the present disclosure is not to be construed as necessarily requiring their performance as described or illustrated. It is also to be understood that additional or alternative steps may be employed.Variations or modifications to the composition of this invention, within the scope of the invention, may occur to those skilled in the art upon reviewing the disclosure herein. Such variations or modifications are well within the spirit of this invention.

[0082] The expression of various quantities in terms of “% w / w” or “% w / v” “%” means the percentage by weight, relative to the weight or volume of the total solution or composition unless otherwise specified.

[0083] The term “active ingredient” (a.i.) or “active agent” or “active” used herein refers to that component of the composition responsible for control of various pests including insects-pests and sucking pests and diseases caused by them at the same time.

[0084] The term “crop” shall include a multitude of desired crop plants or an individual crop plant growing at a locus.

[0085] The term “synergistic”, as used herein, refers to the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects. “Bioactive amounts” as mentioned herein means that amount which, when applied for treatment of crops, is sufficient to give effect in such treatment.

[0086] “Bioactive amounts” as mentioned herein means that amount which, when applied for treatment of crops, is sufficient to give effect in such treatment.

[0087] The term “control” means to inhibit the ability of pests to survive, grow, feed and / or reproduce, or to limit the pests’ related damage or loss in crop plants. To “control” pests may or may not mean killing the pests although, it preferably means killing the pests.

[0088] The term “health of a plant” or “plant health” is defined as a condition of the plant and / or its products. As a result of the improved health; yield, plant vigour, quality and tolerance to abiotic or biotic stress is increased. As a result, the health of a plant is increased even in the absence of pest pressure.Accordingly, in an especially preferred embodiment according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. An increase in plant vigor may for example result in an increased yield and / or tolerance to abiotic or biotic stress.

[0089] One indicator for the condition of the plant is the yield. “Yield” is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits, vegetables, nuts, grains, seeds, wood (e.g., in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and / or processed after harvesting.

[0090] In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

[0091] In another especially preferred embodiment of the invention, the plant vigour of the treated plant is increased. In another preferred embodiment of the invention, the plant vigour of the plants treated according to the composition of the present invention is increased synergistically.

[0092] Another indicator for the condition of the plant is the “quality” of a plant and / or its products.

[0093] In an especially preferred embodiment of the invention, the quality of the treated plant is increased. In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

[0094] The term rain fastness refers to the ability of a substance to remain effective after being applied to a surface and then exposed to rainfall or irrigation. In other words, it measures how well the substance adheres to the target surface and resists being washed away by water. A low rain fastness indicates that it may be washed off or diluted by rainfall, reducing its efficacy.

[0095] The term "Increased uptake of active ingredient" refers to the enhanced absorption or penetration of the active component of a substance into the target organism or plant. This increased uptake can lead to greater effectiveness of the product in controlling various pests and wide range of diseases at the same time. It may occur through various mechanisms, such as improved formulation, additive such as adjuvants that enhance penetration, or modifications to the active ingredient itselfto facilitate absorption. Overall, increased uptake of the active ingredient results in improved performance of the product in achieving its intended purpose.

[0096] The term “benefit: cost” refers to a ratio used in a cost -benefit analysis to summarize the overall relationship between the relative costs and benefits of a proposed composition. If a treatment has a benefit-cost ratio greater than 1.0, the treatment is expected to deliver a positive and better outcome.

[0097] In one embodiment of the present invention, the yield of the treated plant is increased.

[0098] In another embodiment of the present invention, there is synergistic and efficacious control of various pests and associated diseases affecting the plants and crops.

[0099] Another embodiment of the present invention, includes within its scope, all possible salts, esters and derivatives of the active ingredients of the composition.

[0100] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification.

[0101] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control.

[0102] The composition or formulation according to the present invention has a reduced or zero phytotoxicity with respect to agricultural crops. This results in the present invention effective and possible in the selective control of diseases including pest’s control.In an embodiment, the stable synergistic pesticidal composition or formulation has a reduced or zero phytotoxicity with respect to important agricultural crops. This results in the present invention effective and possible in the selective control of diseases caused by pests.

[0103] It has been observed that the composition of present invention not only provides synergistic effect but also provides anti-aging effect to the crops or plants to which it is applied. In addition, the stable synergistic pesticidal composition of the present invention is effective against all developmental stages of pests including egg, nymph, larva, pupa, and adult.

[0104] The term “active ingredient” (a.i.) or “active agent” or “active” used herein refers to that component of the composition responsible for control and killing of pests.

[0105] Sucking pests complex include but is not limited to white fly, jassids, thrips, leafhoppers, Plant hoppers, etc.

[0106] In an embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0107] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0108] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0109] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0110] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0111] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; and

[0112] C) One or more agrochemically acceptable excipients.

[0113] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0114] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0115] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; andC) At least one or more additive.

[0116] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0117] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0118] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives;

[0119] C) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof; and

[0120] D) One or more agrochemically acceptable excipients.

[0121] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0122] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0123] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition.

[0124] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0125] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0126] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0127] C) One or more agrochemically acceptable excipients.

[0128] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0129] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; and

[0130] C) At least one or more additive.

[0131] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0132] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0133] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0134] C) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, in the range of 0.001-20% by weight of the composition; and

[0135] D) One or more agrochemically acceptable excipients.

[0136] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0137] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0138] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;

[0139] C) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, in the range of 0.001-20% by weight of the composition; andD) At least one or more additive.

[0140] In a specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0141] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-45% by weight of the composition; and

[0142] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-45% by weight of the composition.

[0143] In yet another embodiment, the present invention provides a process for preparation of the stable synergistic pesticidal composition comprising:

[0144] A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;

[0145] B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives.

[0146] In accordance with an embodiment of the present invention, there is provided a stable synergistic pesticidal composition comprising active ingredients present in the weight % range as given below:

[0147]

[0148] According to embodiments of the present invention, the stable synergistic pesticidal composition results in an increased yield of the treated plant. Accordingly, there is synergistic and efficacious control of various pests including insect-pests and sucking pests complex etc. affecting the plantsand crops. The present invention includes within its scope, all possible salts, esters and derivatives of the active ingredients of the composition.

[0149] According to embodiments of the present invention the stable synergistic pesticidal composition or formulation according to the present invention has a reduced or zero phytotoxicity with respect to important agricultural crops. This enables the present invention to render effective and selective control of associated diseases.

[0150] In an embodiment of the present invention, the stable synergistic pesticidal composition further optionally comprises additives including but not limited to inert ingredients, carriers, adjuvants, etc. for providing the following attributes to the composition of present invention:

[0151] a) enhanced stability, permeability, and spreading or coverage effect

[0152] b) uniform spray-ability, and storage stability,

[0153] c) improved penetration capacity, and improved rain-fastness,

[0154] d) enriched biotic factors, and better flowability,

[0155] e) longer residual effect, and improved uptake of active ingredients, and safer to the environment.

[0156] According to embodiment of the present invention, the stable synergistic pesticidal composition further optionally comprises additives for providing the attributes such as enhanced stability, enhanced permeability, enhanced efficacy, improved penetration capacity, uniform spray -ability, improved rain-fastness, enriched biotic factors, better flowability, enhanced applicability, reduced foaming, reduced off-site drifting, enhanced spreading or coverage effect, effective storage stability, longer residual effect, improved uptake of active ingredients, better bio-stimulating effects, and safer to the environment and other beneficial properties; to the composition of present invention.

[0157] According to embodiments of the present invention, the stable synergistic pesticidal composition of the present invention further comprises one or more agrochemically acceptable excipients including but not limited to the group comprising surfactant(s), dispersing agent(s), co -dispersant, anti-freezing agent(s), emulsifier(s) (anionic and non-ionic), anti-foaming agent / defoamer(s), wetting agent(s), antimicrobial / anti-bacterial agent(s), anti-caking agent , thickeningagent / thickener(s), quick coating agent(s) or sticking agents / sticker(s), spreader(s), binder(s), pH-adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s) / suspension aid(s), colorant(s), carrier(s), buffering agent(s), polymer(s)rheology modifier(s), solvent(s), co-solvent(s) , biocide or a combination thereof. Additional components may also be included, e.g., protective colloids, carriers, adhesives, thixotropic agents, penetration agents, stabilizers, sequestering agents. More generally, the active materials can be combined with any solid or liquid carrier / additive, which complies with usual formulation techniques.

[0158] An adjuvant used in the present invention is any material that is added to an agrochemical formulation to enhance or modify the performance of the formulation. An adjuvant used in the present invention to make it a safer to ecological environmental, having low toxicity and having no phytotoxicity effects on any part of the plant.

[0159] Examples of surfactant(s) and / or dispersing agent and / or co-dispersant used herein include but not limited polymeric anionic dispersant, polyarylphenyl ether phosphate, tristyryl phenol ethoxylate, Polymethyl methacrylate -polyethylene glycol graft copolymer, acrylate copolymer, acrylic copolymer, Ammonium Distyrylphenyl Ether Sulphate, polymeric dispersant, Calcium salt of alkyl benzene sulphonate, Non-ionic surfactant, polyalkoxylated butyl ether, acrylic graft copolymer, Sodium methyl oleoyl taurate , non-ionic proprietary surfactant, Methyl naphthalene sulfonic acid, polymer with formaldehyde, sodium salt, ethoxylated tristryl phenol Sulphate, alkyl naphthalene formaldehyde condensate , naphthalene sulfonic acid, phenol sulfonic acid-formaldehyde polycondensation as sodium salt, sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, Anionic tristyrylphenol phosphate surfactant, Sodium Alkyl Naphthalene Sulfonate Blend, polyalkelene glycol ether, Sodium alkyl naphthalene sulfonate formaldehyde condensate, Sodium Isopropyl Naphthalene Sulfonate, Dialkyl naphthalene sulphonate sodium salt, Naphthalene Sulphonic Acid, Formaldehyde, Ethoxylated fatty glyceride , Ethoxylated Polyarylphenol Phosphate Ester, Lignosulfonic Acid, Sodium Salt, Sulfomethylated, ethoxylated fatty alcohol, methyl naphthalene sulfonic acid, polymer with formaldehyde sodium salt, Sodium polymethyl methacrylate, sodium polyacrylate, alkyl naphthalene sulfonate formaldehyde condensate or its sodium salt , Sodium Naphthalene Sulfonate formaldehyde condensate, sodium lignosulfonate, calcium lignosulphonate, Sodium Alkyl Naphthalene Sulfonate, alkylphenol polyoxyethylene ether, sodium salt of naphthalene sulfonate condensate,alkyl naphthalene sulfonate condensate blend, polymeric surfactant, sodium salt of alkyl naphthalene sulfonate, sodium salt of methyl naphthalene sulfonate, polycarboxylate or its sodium salt, naphthalene sulfonic acid-branched and linear derivative sodium salts, fatty alcohol polyoxyethylene ether, alcohol polyglycol ether, non-aqueous dispersant - non-ionic polymeric surfactant, aqueous dispersant - polymeric amphoteric aqueous dispersant or mixtures thereof and present in the range of 0.1-20% by weight of the composition.

[0160] Examples of wetting agent used herein include but not limited to tristyrylphenol ethoxylate nonionic emulsifier, mixture of non-ionic surfactants, Blend of Anionic and Non-ionic, alkoxylated alcohol, block copolymer, alcohol polyglycol ether, alkyl olefin sulphates, dioctyl sulpho succinate, alkyl naphthalene sulphate, Di-isopropyl Napthalene sulphonate, Benzenesulfonic acid, Hydroxy polymer with formaldehyde, Phenol and Urea sodium salt, Polyalkoxy ethers, alkyl phenol ethoxylates, tri-styrenated phenol ethoxylate, EO / PO block co-polymers, butyl polyalkylene oxide block copolymer, sodium lauryl sulphonate, Alpha olefin sulphonate, sodium sulphates or mixtures thereof and present in the range of 0.1-20% by weight of the total composition.

[0161] Examples of anti-freezing agent used herein include but not limited to the group comprising glycol, propylene glycol, mono ethylene glycol, glycerine, diethylene glycol, sorbitol, urea, mannitol, Aluminum Magnesium Silicate, polyethylene glycol or mixtures thereof and present in the range of 0.01-20% by weight of the composition.

[0162] Examples of filler used herein include but not limited to the group comprising silicon dioxide, China-clay, kaolin, starch, bentonite, precipitated silica, fumed silica, lactose monohydrate, talcum powder, lactose, ammonium sulphate, water, sodium Sulphate, magnesium sulphate, sodium citrate, sodium chloride, potassium chloride and mixtures thereof and present in the range of 0.001 -60 % by weight of the composition.

[0163] Examples of anti-caking agent used herein include but not limited to the group comprising of talc, hydrous magnesium silicate, magnesium carbonate, calcium carbonate, precipitate silica, silica powder, hydrophobic fumed silica and mixtures thereof and present in the range of 0.001-10% by weight of the composition.Examples of biocide or anti-microbial / anti-bacterial agent(s), agent(s) used herein include but not limited to the group comprising of 1, 2,- Benzisothiazolin -3-one, blends of 1,2-benzisothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, blends of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, zinc 1 -hydroxy -2(1H)-pyridinethione, blends of zinc l-hydroxy-2(lH)-pyridinethione and zinc oxide, and 2-n-octyl-4-isothiazolin-3-one or mixture thereof and present in the range of 0.001 to 10 % by weight of the composition.

[0164] Examples of the rheology modifier or thickeners or thickening agents or suspending agent(s)used herein include but not limited to the group comprising of polysaccharides, carboxymethyl cellulose, bentonite clay, aluminium magnesium silicate, hydroxy propyl cellulose, Sodium methyl cellulose, xanthan gum, gum arabic, Silica powder, gaur gum, carbomer, chitosan, precipitated silica or mixtures thereof and present in the range of 0.001-5.0 % by weight of the composition. Examples of emulsifier(s) used herein include but not limited to the group comprising of araliphatic or aliphatic non-ionic oil emulsifier-ethoxylated sorbitol hexaester derived from oleic acid, emulsifier such as ethoxylated mono-, di- and trialkylphenols, ethoxylates of long-chain alcohols and polyethylene oxide / polypropylene oxide homo- and copolymers, Anionic and nonionic blend of castor oil ethoxylate, Hydrophobically Modified Polyacrylate Copolymer, Polymeric emulsifier (Nonionic polyalkylene oxide block copolymer), Ethoxylates of long-chain alkanols, Castor oil ethoxylate , ethoxylated monoalkylphenol, ethoxilates of cetyl alcohol and / or stearyl alcohol; water soluble emulsifier, Emulsifier (Blend of Anionic and Non-ionic), Tristyrylphenol ethoxylate-20 mole, Alkyl diphenyl sulfonates, Ethoxylated Tristyrylphenol ,and Anionic emulsifier such as alkali metal and ammonium salts of alkyl sulfates, of hemisulfates of ethoxylated alkanols and ethoxylated alkylphenols, alkylsulfonic acids, bis(phenylsulfonic acid) ethers and their alkali metal or ammonium salts, sodiumlaurylsulfate, sodium (cetyl / stearyl) sulfate or mixture thereof and present in the range of 0.001-20 % by weight of the composition.

[0165] Examples of emulsifier(s) used herein is / are selected from group or non-ionic, ionic, or a blend or combination thereof, present in the range of 0.001-20 % by weight of the composition.

[0166] Examples of Non-ionic emulsifier(s) used herein is / are selected from group comprising of Araliphatic or aliphatic non-ionic oil emulsifier - ethoxylated sorbitol hexa-ester derived fromoleic acid, Ethoxylated mono-, di- and trialkylphenols, Ethoxylates of long-chain alcohols, Polyethylene oxide / polypropylene oxide homo- and copolymers, Hydrophobically Modified Polyacrylate Copolymer (nonionic polymeric dispersant), Polymeric emulsifier (Nonionic polyalkylene oxide block copolymer), Ethoxylates of long-chain alkanols, Castor oil ethoxylate, Ethoxylated monoalkylphenol, Ethoxylates of cetyl alcohol and / or stearyl alcohol, Tristyrylphenol ethoxylate, Ethoxylated Tristyrylphenol, Non-ionic water-soluble emulsifiers, or a combination thereof.

[0167] Examples of the ionic emulsifier(s) used herein is / are selected from group comprising of alkali metal and ammonium salts of alkyl sulfates, hemisulfates of ethoxylated alkanols, hemisulfates of ethoxylated alkylphenols, alkylsulfonic acids, bis(phenylsulfonic acid) ethers and their alkali metal or ammonium salts, sodium lauryl sulfate, sodium (cetyl / stearyl) sulfate, Ionic water-soluble emulsifiers or combination thereof.

[0168] Examples of defoamer or antifoaming agent used herein include but not limited to silicon emulsion based anti-foam agents, Siloxane polyalkyleneoxide, Polydimethylsiloxane, Poly alky leneoxide-modified Polydimethylsiloxane, trisiloxane ethoxylates, silicone oil, silicone compound, C10~ C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide polydimethylsiloxane emulsion and mixtures thereof and present in the range of 0.01-5.0% by weight of the composition.

[0169] Examples of solvent(s) and co-solvent(s) used herein include but not limited to polar and nonpolar solvent from the group comprising heavy aromatic hydrocarbon, N methyl pyrollidone (NMP) , Solvent Naphtha (Solvent C-9), Di methyl sulfoxide (DMSO), Dimethylformamide (DMF), N- alcohol, 2-ethyl hexanol , alkyl amide, vegetable oil, mineral oil, distilled water, aromatic solvents, water or mixtures thereof and present in the range of 1.0 to 20% by weight of the composition.

[0170] Examples of colouring pigment(s) / dye(s) used herein include but not limited to red dye FGR03, Permanent Rubin L5-B-01, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1 , pigment blue 80, pigment yellow 1 , pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48: 1 , pigment red 57: 1 , pigment red 53:1 , pigment orange 43, pigment orange34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, violet 23, acid red 51 , acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108 or mixtures thereof and present in the range of 0.01- 10.0 % by weight of the composition.

[0171] Examples of polymer(s) used herein include but not limited to isocyanate, polyisocyanate used is toluene -2, 4-diisocyanate (TDI), diethylenetriamine (DETA), ethylene diamine (EDA), triethylenetetramine (TETA), and / or hexamethylene diamine (HMDA), diethanolglycine sodium salt, ethanoldiglycine disodium salt, hydroxymonocarboxylic acid compounds, hydroxydicarboxylic acid compounds, tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate (GLDA), methylene diisocyanate (MDI), and / or low molecular weight polydiisocynates or mixtures thereof and present in the range of 0.01- 5.0 % by weight of the composition.

[0172] Examples of binder(s) used herein include but not limited to polyvinylpyrrolidone, polyvinyl alcohol, methyl cellulose, and carboxymethyl cellulose, polyisocyanate, polyterpene resin or mixtures thereof and present in the range of 0.01- 40 % by weight of the composition Examples of preservative(s) used herein include but not limited to Methyl paraben (Methyl p-hydroxybenzoate), Propyl paraben (Propyl p-hydroxybenzoate), Methylisothiazolinone (MIT), Chloromethylisothiazolinone (CMIT), Benzisothiazolinone (BIT), DMDM Hydantoin, Imidazolidinyl Urea, Phenol, Cresol, Chlorocresol, Benzoic acid, Sorbic acid, Salicylic acid, Thymol (natural preservative), Sodium benzoate, Potassium sorbate, Bronopol (2-bromo-2-nitropropane-l,3-diol), Propyl para-hydroxy -benzoate or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

[0173] Examples of stabilizer(s) used herein include but not limited to butylated copolymer , Butylated Hydroxy Toluene (BHT), Butylated Hydroxyanisole (BHA), Ascorbic Acid (Vitamin C), Tocopherol (Vitamin E), Tinuvin® (e.g., Tinuvin 1130 - a benzotriazole UV absorber), Hindered Amine Light Stabilizers (HALS), Oxanilide derivatives, Ethoxylated Alkylphenols (e.g., nonylphenol ethoxylates), Block copolymers (e.g., Pluronic® types), Polyvinyl alcohol (PVA), Acrylic or Butylated Copolymers, Citric acid / Sodium citrate, Phosphates (e.g., Sodium or Potassium phosphate), Acetates (e.g., Sodium acetate), EDTA (Ethylenediaminetetraacetic acid),Citric acid (dual role: pH and chelation), NTA (Nitrilotriacetic acid), Xanthan gum, Attapulgite clay, Bentonite, Hydroxypropyl methylcellulose (HPMC) or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

[0174] Examples of pH adjusting agent(s) / buff ering agent(s) used herein include but not limited to Citric Acid, Citric Acid Monohydrate, Citric Acid Dihydrate, Sodium Citrate, Potassium Citrate, Tartaric Acid, Potassium Hydrogen Tartrate, Lactic Acid, Sodium Phosphate (Monobasic or Dibasic), Potassium Phosphate (Monobasic / Dibasic), Sodium Bicarbonate, Sodium Carbonate, Ammonium Acetate / Ammonium Hydroxide, Acetic Acid, Sodium Acetate, Borax (Sodium Borate) or mixture thereof and present in the range of 0.01- 25 % by weight of the composition.

[0175] In yet another embodiments of the present invention, the present stable synergistic pesticidal composition is formulated as but not limited to one or more of Flowable concentrate for seed treatment (FS), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultralow volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW). In yet another embodiment of the present invention, the invention further provides the process for preparation of the said pesticidal composition, wherein the said composition can be one or more of Flowable concentrate for seed treatment (FS), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Granules (GR), Micro-emulsion (ME), Oil -dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC),Suspension concentrate for direct application (SD), Suspo -emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW).

[0176] According to embodiment of the present invention process may include steps including but not limited to mixing, grinding, granulation, or high-shear homogenization, followed by drying, sieving, and packaging.

[0177] In further embodiment, depending on the formulation type, they comprise one or more liquid or solid carriers, appropriate surfactants (such as dispersants, protective colloids, emulsifiers, wetting agents and tackifiers), and appropriate further excipients which are customary for formulating agrochemical compositions. Further excipients include e.g. organic and inorganic thickeners, bactericides, antifreeze agents, antifoams, colorants and, for seed formulations, adhesives.

[0178] Suitable carriers include liquid and solid carriers. Liquid carriers include e.g. non-aqueous solvents such as cyclic and aromatic hydrocarbons, e.g. paraffins, tetrahydronaphthalene, alkylated naphthalenes and their derivatives, alkylated benzenes and their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, ketones such as cyclohexanone, strongly polar solvents, e.g. amines such as N-methylpyrrolidone, and water as well as mixtures thereof. Solid carriers include e.g. mineral earths such as silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and products of vegetable origin such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders, or other solid carriers.

[0179] In one embodiment, additives such as Siloxane Polyalkyleneoxide Copolymer or an organosilicone based powder adjuvant that can enhance the water absorption efficiency of hard-to-wet soils by increasing their water infiltration, drainage, water retention and hydrophilicity;tallow amine ethoxylate increases the biocompatibility in environmental applications and help in the interactions of active ingredients; ammonium sulphate help is resistant to leaching and helps the crop to utilize nitrogen efficiently; urea clathrate provides superior wetting and spray retention properties and serves as an excellent nitrogen source for crops and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition; and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition. The said additives are stable and hygroscopic resulting in an efficient uptake and functioning.

[0180] In one embodiment, in agrochemical compositions, additives such as urea clathrate, Siloxane Polyalkyleneoxide Copolymer or organosilicone -based powder adjuvant, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil (ESO) serve distinct yet complementary functions, both individually and synergistically. Urea clathrate stabilizes volatile active ingredients by encapsulating them, thereby improving shelf life and enabling controlled release. Siloxane Polyalkyleneoxide Copolymer or organosilicone -based powder adjuvant Super-wetter, which are trisiloxane -based super spreaders, reduce surface tension significantly and enhance the spreading, wetting, and penetration of the formulation on plant surfaces, improving bioavailability. Tallow amine ethoxylate, a non-ionic surfactant, aids in emulsification and acts as a strong adjuvant, enhancing the uptake of systemic active ingredients. Ammonium sulphate is commonly used as a water conditioner to prevent antagonism from hard water ions like calcium and magnesium; it also enhances the absorption of certain fungicides and insecticides. Epoxide soybean oil (ESO) contributes as a stabilizer and plasticizer, protecting active ingredients from UV and oxidative degradation while improving formulation compatibility.

[0181] In another embodiment, when used in combination in agrochemical composition, these additives enhance the overall efficacy, stability, and environmental safety of the agrochemical composition. For instance, the combined use of Siloxane Polyalkyleneoxide Copolymer and ammonium sulphate can significantly boost pesticide performance, while ESO and urea clathrate together offer enhanced protection and sustained release of active ingredients. Thus, their synergistic interaction leads to improved performance and consistency under varying environmental and application conditions.In one embodiment, additives such as urea clathrate, Siloxane Polyalkyleneoxide Copolymer, or an organosilicon based powder adjuvant, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, present in the range of 0.01 - 20% by weight of the composition.

[0182] The said additives are stable and hygroscopic resulting in an efficient uptake and functioning. In one embodiment, additives such as urea clathrate, Siloxane Polyalkyleneoxide Copolymer or an organosilicone -based powder adjuvant, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, present in the range of 0.001 - 20% by weight of the composition.

[0183] According to embodiments of the present invention, the present stable synergistic pesticidal composition can be applied to various crops and plants including but not limited to Cereals including aubergine, brinjal, cabbage, chilli, cotton, okra, red gram, tomato, fruit, rice (paddy), rice, strawberries, tea, vegetables, etc.

[0184] According to embodiments of the present invention, the present stable synergistic pesticidal composition provides synergistic and effective control against various pests such as sucking pests including but not limited to leaf hopper, thrips, fruit and shoot borer, Diamond back moth, tobacco caterpillar, semi looper, spotted pod borer, pod borer, thrips, brown plant hopper, whitefly, jassids, aphids, Leaf Hopper, white backed plant hopper and green leaf hopper, houseflies, spider mite, leafhoppers, mealybugs, plant hoppers, leaf miners, etc. .

[0185] According to embodiments of the present invention, the present stable synergistic pesticidal composition of present invention can be applied to any and all developmental stages of pests, insect-pests, sucking pests including egg, nymph, larva, and adult. The pests may be controlled by contacting the target pest, habitat, breeding ground or its locus with a bioactive amount of the novel and inventive composition of the present invention.

[0186] In yet another embodiment, the present stable synergistic pesticidal composition of the present invention can be applied to a plant / crop / soil by spraying, rubbing, atomizing, irrigating,evaporating, dusting, fogging, broadcasting, pouring, mist blowing, soil mixing, foaming, painting, spreading-on, drenching, dipping or drip irrigation, etc.

[0187] In yet another embodiment, the composition of the present invention can also comprise or may be applied together and / or sequentially with further active compounds. These further compounds can be selected from fertilizers or micronutrient donors or microorganisms or other preparations that influence plant growth, such as inoculants (e.g., a strain of nitrogen-fixing bacteria), and plant inducers.

[0188] In an embodiment of the present invention, the stable synergistic pesticidal composition further optionally comprises additives for providing the following attributes to the composition of present invention:

[0189] a) enhanced stability, enhanced permeability and enhanced efficacy,

[0190] b) improved penetration capacity and improved rain-fastness,

[0191] c) uniform spray-ability,

[0192] d) enriched biotic factors,

[0193] e) better flowability or enhanced applicability,

[0194] f) reduced foaming and reduced off-site drifting,

[0195] g) enhanced spreading or coverage effect,

[0196] h) effective storage stability and longer residual effect,

[0197] i) improved uptake of active ingredients,

[0198] j) better bio-stimulating effects, and safer to the environment and other beneficial properties.

[0199] The novel composition of the present invention has very advantageous, curative, preventive and systemic pesticidal properties for protecting cultivated plants and crops. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens.

[0200] The composition of the present invention also provides control of diseases caused by a broad spectrum of insect plant pathogens preventatively or curatively by applying an effective amount of the composition either pre-or post-infection.Plant disease control is ordinarily accomplished by applying an effective amount of a synergistic composition of the present invention either pre -or post-infection, to the portion of the plant to be protected such as the roots, stems, foliage, fruit, seeds, tubers or bulbs, or to the media (soil or sand) in which the plants to be protected are growing. The composition can also be applied to the seed to protect the seed and seedling.

[0201] Thus, before describing the present invention in detail, it is to be understood that this invention is not limited to particularly exemplified systems or process parameters that may of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control. In one embodiment, the composition according to the present invention acts synergistically to control pests in various crops.

[0202] Representative examples of the present composition of this invention are provided below and are not to be construed as limiting in any manner:

[0203] EXAMPLES: GENERAL RECIPE OF COMPOSITION OF PRESENT INVENTION:

[0204]

[0205]

[0206]

[0207]

[0208]

[0209]

[0210]

[0211] EXAMPLE A: Stable synergistic pesticidal composition comprising Dinotefuron 16% + Fluxametamide 16% SC

[0212]

[0213] 1. FORMULATION PROCESS

[0214] A. Pre-Mixing

[0215] 1. Into a clean reactor charge D M Water and start the stirring.

[0216] 2. Add Propylene glycol, Acrylic Graft Copolymer, Polyalkoxy ethers, Ethoxylated Polyarylphenol Phosphate Ester, Poly dimethyl siloxane and l,2-Benzisothiazolin-3- one. Mix well to make a homogeneous solution.

[0217] 3. To this add Dinotefuron technical and Fluxametamide technical and mix well to form a homogeneous slurry.

[0218] B. Wet-Milling process1. Allow to pass the premix through the bead mill at 400 to 500 Ltr / hr feed rate so as get a desired particle size.

[0219] 2. The grinded material is collected in post blender.

[0220] C. Post Mixing

[0221] 1. The milled slurry is collected into the post blender and to this pre hydrated xanthun gum is added.

[0222] 2. Mix well till the slurry attains right viscosity.

[0223] 3. Pack the formulation into HDPE bottles.

[0224] Stability Data: Dinotefuran 16% + Fluxametamide 16% SC

[0225]

[0226] EXAMPLE B: Stable synergistic pesticidal composition comprising Dinotefuron 32% + Fluxametamide 0.1 % WP

[0227]

[0228] MANUFACTURING PROCESS:

[0229] 1. All required Technicals, i.e., Dinotefuran Technical, Fluxametamide Technical and inert ingredients were mixed and then ground in an air jet mill.

[0230] 2. The particle size was checked after grinding to ensure that it was less than 10 microns (D90).

[0231] 3. The ground powder was post-blended and mixed well.

[0232] STABILITY DATA: Dinotefuran 32% + Fluxametamide 0.1 % WP

[0233]

[0234]

[0235] Example C: Stable synergistic pesticidal composition Dinotefuran 34% + Fluxametamide 24 % WG

[0236]

[0237] MANUFACTURING PROCESS:

[0238] China clay was taken in the ribbon blender for mixing. To this, Silica ppt, Sodium Isopropyl Naphthalene Sulfonate, Sodium Lignosulphonate, Sodium Methyl Oleoyl Taurate, SodiumPolycarboxylate, Lactose monohydrate, Dinotefuran Technical, Fluxametamide Technical were added and mixed well.

[0239] Mixing was continued until the material became completely homogenized. The premix was then passed through the Airjet mill at 6 to 7 kg / cm2of grinding pressure and a feeding rate of 100 to 150 kg / hr so as to obtain a particle size of D90 less than 10 microns. The ground material was collected in the post blender.

[0240] Extrusion process

[0241] Into the post blender, the solution of water and Polydimethylsiloxane emulsion was added by means of spraying, and a dough was prepared. This dough was mixed well to obtain a well-hydrated mass for extrusion. The dough was then allowed to pass through the screw valve fitted with the post blender and subsequently passed through the basket extruder.

[0242] Drying Process

[0243] The wet extruded granules were passed through the VFBG (vibro fluid bed drier), which had been brought to a consistent temperature of 50 °C prior to drying. The granules were then checked for moisture content, which was required to be not more than 3%. Once the parameter was set, the process was continued.

[0244] The dried granules were passed through a vibro sieve machine to separate any lumps or dust, and the desired size granules were collected and packed.

[0245] STABILITY DATA: Dinotefuran 34% + Fluxametamide 24 % WG

[0246]

[0247] Evaluation of synergistic effect of pesticidal composition of the present invention

[0248] A synergistic effect of two or more products exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components. Synergism was calculated by using Colby’s method (Weeds, vol. 15 No. 1 (Jan 1967), pp. 20-2).

[0249] The synergistic action expected for a given combination of two active components can be calculated as follows:

[0250] XY

[0251] E = (X + Y) - - 100

[0252] Where:

[0253] E represents expected percentage of pesticidal control for the combination of the two or three active ingredients at defined doses (for example equal to x, y and z, respectively).

[0254] X is the percentage of pesticidal control observed by the compound (Dinotefuran) at a defined dose (equal to x).

[0255] Y is the percentage of pesticidal control observed by the compound (Fluxametamide) at a defined dose (equal to y).

[0256] When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergism effect.

[0257] Observed control (%)

[0258] Ratio = - Expected control (%)

[0259] Ratio of O / E > 1, synergism observed

[0260] The present invention is illustrated by way of examples, the examples are meant for illustrative purposes and should not be construed as limiting.

[0261] Experiment for Synergistic activity of stable synergistic pesticidal composition of present invention:

[0262] Example 1- Details of experiment on Okra crop:Field experiment for synergistic activity of Dinotefuran+Fluxametamide for the control of whitefly and jassid in Okra crop was conducted.

[0263] To evaluate the synergistic effect, Okra [Variety: Hisar Unnat] crop was sown in 5 m x 5 m plots maintaining 65 cm x 60 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of SC formulation @250 ml / ha. Each active component was applied twice in binary composition. Solo components were also taken for comparison. The treatment details are as under:

[0264]

[0265] The treatments T1 to T12 were used as foliar application whereas no treatment was done for T13 control treatment. Two applications of each treatment were carried out at 15 -day intervals, initiated upon reaching the Economic Threshold Level (ETL) of the target insect population in the experimental plots. Observations on whitefly (Bemisia tabaci) and Jassid (Amrasca bisuttula bisuttula ) were recorded before spraying and at 14 days after the first and second applications. For each of the 10 randomly selected Okra plants per plot, three leaves: one each from the upper, middle and lower canopy were examined to assess the whitefly and jassid population. Based on the percent reduction at 14 days after second spray in insect population the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 1A.Table 1A: Synergistic effect of stable synergistic pesticidal composition of the present invention comprising “Dinotefuran + Fluxametamide” against whitefly (Bemisia tabaci} and Jassid (Amrasca bisuttula bisuttula) in Okra crop

[0266]

[0267] It is clearly evident from the data presented in Table 1A on percent pest control in Okra that the binary pesticidal composition comprising Dinotefuran + Fluxametamide (treatments T1 to T4) exhibits a synergistic effect against pests, as indicated by a Colby’s ratio greater than 1. The Colby’s ratio here reflects the combined efficacy against Whitefly and Jassids in Okra.

[0268] Experiment for Bio-efficacy evaluation of stable synergistic pesticidal composition of present invention:

[0269] For the stable synergistic pesticidal composition comprising Dinotefuran 16%+ Fluxametamide 16% SC was evaluated under field conditions, the basic test composition as Dinotefuran 16% + Fluxametamide 16% SC were manufactured. The solo formulations of Dinotefuran 16% SC, andFluxametamide 16% SC were used for comparison. The other formulations namely Dinotefuran 70 % WG and Fluxametamide 10% w / w EC available in the market were also used for comparison.

[0270] Example 2: Evaluation of the stable synergistic pesticidal composition of the present invention on Okra

[0271] The synergistic composition of the present invention Dinotefuran 16% + Fluxametamide 16% was evaluated on Okra crop [Variety: Hisar Unnat]. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 60 cm x 60 cm between plants and rows.

[0272] The observations were recorded for the following objectives.

[0273] Objectives:

[0274] 1. Bio-efficacy evaluation against whitefly on Okra crop

[0275] 2. Bio-efficacy evaluation against jassid on Okra crop

[0276] 3. Bio-efficacy evaluation based on percent reduction in whitefly population

[0277] 4. Bio-efficacy evaluation based on percent reduction in jassid population

[0278] 5. Bio-efficacy evaluation based on Okra crop yield.

[0279] 6. Phytotoxicity evaluation on Okra crop

[0280] Treatment details:

[0281]

[0282] Methodology:

[0283] The treatments T1 to T7 and T9 were used as foliar application whereas no treatment was done for T8 i.e. control treatment. All treatments were applied at the time of initiation of pest in the experimental plots.

[0284] Observations on whitefly (Bemisia tabaci) and Jassid (Amrasca biguttula biguttula) were recorded before spraying at 14 days after the first and second applications. For each of the 10 randomly selected Okra plants per plot, three leaves: one each from the upper, middle and lower canopy were examined to assess the whitefly and jassid population. The percent reduction in pest population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on Okra crop at 1, 3, 7, 10 and 14 days after 1stspray were also recorded. The data were subjected to statistical analysis of variance. Results are presented in Table 2A, 2B, 2C and 2D.

[0285] Results:

[0286] Table 2A: Field bio-efficacy evaluation of stable synergistic pesticidal composition comprising Dinotefuran 16% + Fluxametamide 16% SC against whitefly of Okra crop

[0287]

[0288]

[0289] Table 2B: Field bio-efficacy evaluation of stable synergistic pesticidal composition Dinotefuran 16% + Fluxametamide 16% SC against jassid of Okra crop

[0290]

[0291] Figures in parentheses are square root transformed values; NS= non-significant; DAS: Days after spray Table 2C: Field bio-efficacy evaluation of stable synergistic pesticidal composition comprising Dinotefuran 16% + Fluxametamide 16% SC based on Okra yield.

[0292]

[0293] DAS - Days after crop sowing; q / ha: quintal per hectare

[0294] Table 2D: Phytotoxicity evaluation of stable synergistic pesticidal composition comprising Dinotefuran 16% + Fluxametamide 16% SC on Okra crop

[0295]

[0296]

[0297] From the example, it is clearly seen that the stable synergistic pesticidal composition of the present invention is superior for controlling the whitefly population 14 days after 1st& 2ndspray (Table 2A) and for controlling Jassid population at 14 days after 1st& 2ndspray (Table 2B) in Okra crop as compared to the other pesticides such as Dinotefuran 70 % WG and Fluxametamide 10% w / w EC available in the market. The yield of Okra crop also improved in as compared to binary as compared to solo compositions (Table 2C).

[0298] The disclosed stable synergistic pesticidal composition as compared to @ 187.5ml, 250 ml, 367.5 ml and 500 ml / ha further showed no phytotoxicity in the Okra crop even after 1, 3, 7, 10 and 14 days after 1stspray (Table 2D).

[0299] It is evident from the above data that the stable synergistic pesticidal composition of the present invention comprising Dinotefuran + Fluxametamide resulted in good control of whitefly and jassid in Okra with higher respective yields as compared to the reference standard products (market products and solo products). Further, the composition of present invention is resulted synergistic. Through the pesticidal composition of present invention, the number of applications to control wide range of pests appearing at the same time is minimised. The composition of present invention is highly safe to the user and to the environment. The composition offers the user a single homogenous application eliminating the need for tank mix. The composition is cost-effective as it provides much greater simultaneous control and can be used in a variety of crops with a broader spectrum of protection.

[0300] In particular, it has now been found, surprisingly that, for example, the pesticidal activity of the composition of present invention, compared with the pesticidal activity of individual components, is synergistic. In fact, various advantageous properties associated with the compositions according to the invention, include but are not limited to: a broadening of the spectrum of pesticidal activity to other pests, for example to resistant strains; a reduction in the rate of application of the active ingredients; adequate control of the pests at a rate of application at which the individual compounds are not very effective, advantageous behaviour during formulating and / or upon application, improved stability, improved crop characteristics including crop yields, more developed rootsystem, increase in plant health including height, improved plant vigor, less plant verse (lodging), and other advantages familiar to a person skilled in the art.

[0301] From the above investigations, it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present invention. It is to be understood that no limitations with respect to the specific embodiments illustrated is intended or should be inferred. It should be understood that all such modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the following claims.

Claims

UWE CLAIM:

1. . A stable synergistic pesticidal composition comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; andB) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivative.

2. . The stable synergistic pesticidal composition as claimed in claim 1, comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition; andB) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition.

3. . A stable synergistic pesticidal composition comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; andC) At least one or more additive.

4. . The stable synergistic pesticidal composition as claimed in claim 3, comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives;B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives; andC) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof.

5. . The stable synergistic pesticidal composition as claimed in claims 3-4, comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivatives, in the range of 0.001-90% by weight of the composition;C) At least an additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, in the range of 0.001-20% by weight of the composition

6. . The stable synergistic pesticidal composition as claimed in claims 1-5, which further comprises one or more agrochemically acceptable excipients.

7. . The stable synergistic pesticidal composition as claimed in claim 6, wherein agrochemically acceptable excipients comprises surfactant(s), dispersing agent(s), co -dispersant, anti-freezing agent(s), emulsifier(s), anti-foaming agent / defoamer(s), wetting agent(s), biocide / antimicrobial / anti-bacterial agent(s), thickening agent / thickener(s), quick coating agent(s) or sticking agents / sticker(s), spreader(s), binder(s), pH-adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s) / suspension aid(s), colorant(s) / colouring agent(s) / dye(s), carrier(s), buffering agent(s), polymer(s), rheology modifier(s), solvent(s), co-solvent(s) or mixtures thereof.

8. . The stable synergistic pesticidal composition as claimed in any one of the claims 1 to 7, wherein the composition is in form of Emulsifiable concentrate (EC), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR Micro-emulsion concentrate (MEC), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed composition of CS and SC (ZC) or a mixed composition of CS and SE (ZE) and a mixed composition of CS and EW (ZW).

9. . The stable synergistic pesticidal composition as claimed in claims 1 to 7, wherein the said composition promotes plant health, growth, protection from pests, and increases plant yield in the field.

10. . A process for preparation of the stable synergistic pesticidal composition comprising:A) Fluxametamide or its isomers, agrochemically acceptable salts, esters and derivatives; and B) Dinotefuran or its isomers, agrochemically acceptable salts, esters and derivative.

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