Labware equipment handling system

Abstract

An equipment handling system for providing equipment through a port in an enclosure. The equipment handling system includes a vertical cabinet configured to store a stack of labware. A labware platform is configured to receive and support labware from the stack. A z-axis carriage is configured to move vertically within the vertical cabinet and interface with the labware platform to move it vertically. A first set of locating pins is configured to engage with the labware platform during vertical movement. An x-axis carriage is configured to receive the labware platform from the z-axis carriage at a bottom position and move it horizontally into the enclosure. A second set of locating pins is configured to engage with the labware platform as the first set disengages.

Description

Docket No. 0082-0034PCT1LABWARE EQUIPMENT HANDLING SYSTEMCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Application No. 63 / 749,228, titled "ROBOTIC LAB WARE MODULE FOR A PIPETTE SYSTEM”, filed January 24, 2025, which is hereby incorporated by reference in its entirety for all purposes.FIELD OF INVENTION

[0002] The present disclosure relates to equipment handling systems for liquid handling and pipette systems, and more particularly to systems and methods for providing calibrated delivery and handling of laboratory equipment and labware through a port in an enclosure of a pipette system using coordinated vertical and horizontal carriage mechanisms.BACKGROUND

[0003] Liquid handling systems, such as pipette systems, are widely used in laboratory environments for processing samples, dispensing reagents, and performing various automated protocols. These systems typically include robotic elements, moveable stages, and selectively couplable pipettes that can be positioned above receptacles, reaction containers, or other devices used to react liquid solutions. A pipette robot may include an XYZ gantry, one or more pipettes attached to the gantry, and a deck upon which labware can be situated. During operation, the robot moves the gantry about a rigid frame to perform various operations with respect to the labware, such as aspirating and dispensing liquids.

[0004] In many implementations, the pipettes, receptacles, and devices used in liquid handling operations are located within an enclosed space. This enclosure isolates the reactions from the outside environment, preventing interference from external objects and maintaining controlled conditions during processing. The enclosed nature of these systems presents challenges when additional equipment or labware is required during a protocol.

[0005] When a liquid handling system is used to process large numbers of samples, the system may exhaust its supply of consumables such as pipette tips, well plates, or reagent reservoirs before completing a protocol. In conventional systems, this situation requires stopping the protocol to manually add additional labware and equipment. Such interruptions can be time-consuming and may compromise the integrity of ongoing reactions or processes.Docket No. G082-0034PCT1

[0006] Adding new equipment to an existing liquid handling system typically requires calibration so that the system can identify where the new equipment is located in XYZ space within the enclosure. This calibration process enables the robotic elements to interact with the new equipment accurately. However, calibration can be tedious and time-consuming, requiring additional effort from users during system setup. Incorrect calibration may result in errors or crashes during operation of the system.

[0007] Various approaches have been used to address the challenge of providing additional equipment to liquid handling systems. Some approaches involve applying offsets or calibrations at the factory. Other approaches probe the position of new equipment using the pipette or similar components to determine its location after physical mounting. Still other approaches involve handteaching the robot's gripper where new equipment is presenting labware. Each of these approaches has associated drawbacks in terms of complexity, time requirements, or potential for error.

[0008] There remains a desire for systems and methods that can provide equipment into an enclosure of a liquid handling system in an accurate and repeatable manner while reducing or eliminating the calibration burden on users.BRIEF DESCRIPTION OF FIGURES

[0009] Non-limiting and non-exhaustive examples are described with reference to the following figures.

[0010] FIG. 1 illustrates a liquid handling system with an equipment handling module attached, according to at least one example.

[0011] FIG. 2 illustrates an equipment handling module configured to interface with a liquid handling system, according to at least one example.

[0012] FIG. 3 illustrates an equipment handling module with a cabinet and shuttle module, according to at least one example.

[0013] FIG. 4 illustrates an equipment handling module assembly with multiple vertical cabinets arranged in a side-by-side configuration, according to at least one example.

[0014] FIG. 5 illustrates an equipment handling module with a vertical cabinet and shuttle module extending from the base, according to at least one example.

[0015] FIG. 6 illustrates an equipment handling module showing the relationship between a vertical cabinet and a shuttle module, according to at least one example.Docket No. G082-0034PCT1

[0016] FIG. 7 illustrates an equipment handling module showing labware lowered onto the shuttle module, according to at least one example.

[0017] FIG. 8 illustrates an equipment handling system with a shuttle module and horizontal axis module, according to at least one example.

[0018] FIG. 9 illustrates a transition system configured to transfer a labware platform between a z-axis carriage and an x-axis carriage, according to at least one example.

[0019] FIG. 10 illustrates a shuttle module configured to transfer a labware platform between a z-axis carriage and an x-axis carriage, according to at least one example.

[0020] FIG. 11 illustrates a shuttle module configured to interface with an enclosure of a pipette system, according to at least one example.

[0021] FIG. 12 illustrates a shuttle module with internal components for vertical and horizontal transport of labware, according to at least one example.

[0022] FIG. 13 illustrates a labware platform configured to receive and support labware within an equipment handling system, according to at least one example.

[0023] FIG. 14 illustrates a latch mechanism configured to retain and release labware within a vertical cabinet, according to at least one example.

[0024] FIG. 15 illustrates a latch mechanism with a cam and follower system for controlling support arm movement, according to at least one example.

[0025] FIG. 16 illustrates a portion of an equipment handling module with components for transitioning labware from vertical to horizontal movement, according to at least one example.

[0026] FIG. 17 illustrates a portion of an equipment handling module showing an interaction between a z-axis carriage and an x-axis carriage during a vertical to horizontal transfer of a labware platform, according to at least one example.DETAILED DESCRIPTION

[0027] The following description sets forth exemplary aspects of the present disclosure. It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure. Rather, the description also encompasses combinations and modifications to those exemplary aspects described herein.

[0028] An equipment handling system may be configured to provide equipment through a port in an enclosure of a pipette system. The equipment handling system may include a vertical cabinet configured to store a stack of labware. The vertical cabinet may be an enclosed structureDocket No. 0082-0034PCT1that receives and holds multiple pieces of labware arranged in a stacked configuration. The labware may include tip racks, PCR plates, deep well plates, reagent reservoirs, and other laboratory equipment.

[0029] The equipment handling system may include a labware platform configured to receive labware from the stack of labware and support the labware. The labware platform may be a flat, rectangular component that interfaces with both vertical and horizontal transport mechanisms within the equipment handling system. The labware platform may include features such as pockets, recesses, and mounting surfaces that enable engagement with various mechanical components during transport operations.

[0030] The equipment handling system may include a z-axis carriage configured to move vertically within the vertical cabinet and interface with the labware platform to move the labware platform within the vertical cabinet. The z-axis carriage may include a first set of locating pins configured to engage with the labware platform during vertical movement. The first set of locating pins may extend from the z-axis carriage and engage with corresponding pockets or recesses in the labware platform to provide accurate positioning during vertical travel.

[0031] The equipment handling system may include an x-axis carriage configured to receive the labware platform from the z-axis carriage when the z-axis carriage reaches a bottom position of travel and transport the labware platform horizontally into the enclosure of the pipette system. The x-axis carriage may include a second set of locating pins configured to engage with the labware platform during horizontal transport. The second set of locating pins may engage with the labware platform as the first set of locating pins disengage from the labware platform. This handoff between the z-axis carriage and the x-axis carriage may enable transfer of the labware platform from vertical movement to horizontal movement without requiring simultaneous engagement of both sets of locating pins.

[0032] In some cases, the z-axis carriage may include a first set of magnets configured to magnetically engage with the labware platform during vertical movement. The x-axis carriage may include a second set of magnets configured to magnetically engage with the labware platform during horizontal transport. The magnets may draw the labware platform toward the respective carriage and maintain the labware platform in contact with the locating pins during movement. The magnetic engagement may prevent the labware platform from resting on or binding against the locating pins during transitions between carriages.Docket No. 0082-0034PCT1

[0033] The equipment handling system may include a set of spring-loaded pins disposed adjacent the bottom position of the z-axis carriage. The spring-loaded pins may be configured to disengage the labware platform from the z-axis carriage as the z-axis carriage lowers to the bottom position. In some cases, the z-axis carriage may be configured to compress the spring-loaded pins as the z-axis carriage lowers to the bottom position. Compression of the spring-loaded pins may cause the spring-loaded pins to disengage from the labware platform. The spring-loaded pins may provide a temporary support surface for the labware platform during the transition between the z-axis carriage and the x-axis carriage, and the spring force of the spring-loaded pins may be greater than the magnetic force of the magnets on the z-axis carriage to enable separation of the labware platform from the z-axis carriage.

[0034] The equipment handling system may include a latch mechanism configured to retain the stack of labware within the vertical cabinet. The latch mechanism may include a pair of support arms positioned on opposite sides of the vertical cabinet. Each support arm may be configured to pivot between a retaining position and a release position. The latch mechanism may include a cam and follower system coupled to the support arms. The latch mechanism may include a motor configured to drive the cam and follower system to pivot the support arms from the retaining position to the release position, thereby releasing labware from the stack onto the labware platform when the z-axis carriage is at a top position. In some cases, each support arm may include a hookshaped element configured to engage with a corresponding feature on the labware. The support arms may be configured to pivot on cams to move laterally between the retaining position and the release position.

[0035] The equipment handling system may include a first magnetic switch positioned on the x-axis carriage. The first magnetic switch may be configured to detect the presence of the labware platform on the x-axis carriage. The equipment handling system may include a second magnetic switch positioned at an end of travel of the x-axis carriage within the enclosure of the pipette system. The second magnetic switch may be configured to indicate when the x-axis carriage has reached the end of travel. The magnetic switches may provide feedback to a control system regarding the position of the labware platform and the x-axis carriage during operation.

[0036] In some cases, the z-axis carriage may include a U-shaped configuration defining an interior space. The x-axis carriage may be configured to fit within the interior space formed by the U-shaped configuration of the z-axis carriage when the z-axis carriage is at the bottom position ofDocket No. 0082-0034PCT1travel. This arrangement may enable the z-axis carriage to move past the x-axis carriage along the vertical direction without interference.

[0037] In some cases, the bottom position of the z-axis carriage may be positioned such that an upper end of the first set of locating pins is below a bottom surface of the labware platform when the labware platform is positioned on the x-axis carriage. This positioning may enable the x-axis carriage to move horizontally without interference from the first set of locating pins on the z-axis carriage.

[0038] The z-axis carriage may include a first geometry and the x-axis carriage may include a second geometry. The first geometry of the z-axis carriage and the second geometry of the x-axis carriage may be configured to enable the z-axis carriage to move past the x-axis carriage and the x-axis carriage to move past the z-axis carriage along their respective directions of travel without interference. In some cases, the first geometry of the z-axis carriage may define an open middle space, and the second geometry of the x-axis carriage may be configured to reside within the open middle space of the z-axis carriage when the z-axis carriage is at a bottom position of travel. In other cases, the second geometry of the x-axis carriage may define an open middle space, and the first geometry of the z-axis carriage may be configured to reside within the open middle space of the x-axis carriage when the z-axis carriage is at a bottom position of travel.

[0039] A method for providing equipment through a port in an enclosure of a pipette system may include storing a stack of labware in a vertical cabinet. The method may include positioning a labware platform to receive labware from the stack of labware. The method may include engaging the labware platform with a z-axis carriage using a first set of locating pins. The method may include moving the z-axis carriage vertically within the vertical cabinet to lower the labware platform to a bottom position of travel. The method may include disengaging the first set of locating pins from the labware platform as the z-axis carriage reaches the bottom position of travel. The method may include engaging the labware platform with an x-axis carriage using a second set of locating pins. The method may include transporting the labware platform horizontally into the enclosure of the pipette system using the x-axis carriage.

[0040] In some cases, the method may include detecting the presence of the labware platform on the x-axis carriage using a first magnetic switch positioned on the x-axis carriage. The method may include determining when the x-axis carriage has reached an end of travel within the enclosure of the pipette system using a second magnetic switch positioned at the end of travel.Docket No. 0082-0034PCT1

[0041] In some cases, the method may include retaining the stack of labware within the vertical cabinet using a latch mechanism comprising a pair of support arms positioned on opposite sides of the vertical cabinet. The method may include pivoting the support arms from a retaining position to a release position using a cam and follower system driven by a motor to release labware from the stack onto the lab ware platform.

[0042] Referring to FIG. 1, a liquid handling system 100 may include a pipette system 102 and an equipment handling module 104 positioned adjacent to the pipette system 102. The liquid handling system 100 may be configured to process samples using robotic elements and selectively couplable pipettes that may be coupled to a movable stage within the pipette system 102.

[0043] The pipette system 102 may include an enclosed rectangular housing with multiple structural frame members and mounting points arranged along exterior surfaces of the pipette system 102. The pipette system 102 may include a deck area visible through a front panel, the deck area containing internal components including horizontal support structures and mounting features. The enclosed housing of the pipette system 102 may isolate reactions and processes from an outside environment to prevent interruption by external objects.

[0044] The equipment handling module 104 may be positioned adjacent to a side of the pipette system 102 and may be configured to provide labware through a port in the enclosure of the pipette system 102. The equipment handling module 104 may include a cabinet 106 positioned at an upper portion of the equipment handling module 104. The cabinet 106 may be configured to store a stack of lab ware. The cabinet 106 may feature an elongated rectangular housing with multiple mounting holes arranged vertically along an exterior surface of the cabinet 106 that may be used to couple adjacent equipment handling modules to each other.

[0045] A shuttle component 108 may extend from the cabinet 106 and may be configured to transport labware from the cabinet 106 into the enclosure of the pipette system 102. The shuttle component 108 may include mechanical elements that enable movement of labware along a horizontal axis for delivery into the liquid handling system 100.

[0046] A mounting component 110 may be positioned at a deck of the pipette system 102 and may provide a connection interface between the equipment handling module 104 and a deck of the liquid handling system 100. The mounting component 110 may include structural features that facilitate secure attachment and alignment of the equipment handling module 104 with the pipette system 102. The mounting component 110 may enable the equipment handling module 104 toDocket No. G082-0034PCT1deliver labware into the enclosure at the deck of the pipette system at an accurate location without requiring calibration of the position of the equipment handling module 104.

[0047] Leveling feet 112 may be positioned at bottom corners of the liquid handling system 100, extending downward from a base structure. As shown in FIG. 1, three leveling feet 112 and 114 are visible, providing support and stability for the liquid handling system 100 on various supporting surfaces. In some cases, at least one of the leveling feet 112 and 114 may be a spring-loaded leveling foot configured to self-level and support a portion of the weight of the equipment handling module 104 without requiring manual adjustment by a user. The spring-loaded leveling foot may include a spring that is sufficiently strong to support at least a portion of the weight of the equipment handling module 104, with the remainder of the weight of the equipment handling module 104 being borne by the pipette system 102 through the mounting component 110.

[0048] A drive system 116 may be positioned at a lower portion of the equipment handling module 104. The drive system 116 may include mechanical and electrical components that provide functionality for the equipment handling module 104. The drive system 116 may house drive mechanisms and control elements for operating the shuttle component 108 and the cabinet 106.

[0049] Referring to FIG. 2, an equipment handling module 200 may be configured to interface with a liquid handling system. The equipment handling module 200 may include a vertical cabinet 202 positioned at an upper portion of the equipment handling module 200. The vertical cabinet 202 may feature an elongated rectangular housing configured to store a stack of labware. The vertical cabinet 202 may include multiple mounting holes arranged in a pattern along side faces of the vertical cabinet 202, which may facilitate attachment and alignment with other components or structures such as adjacent equipment handling modules. In some cases, the vertical cabinet 202 may include a viewing window for visually observing a level of labware within the vertical cabinet 202.

[0050] A door 204 may be positioned on one side of the vertical cabinet 202. The door 204 may provide access to an interior storage area of the vertical cabinet 202 for loading and unloading labware. The door 204 may include a handle that may appear as a rectangular panel element extending from a side surface of the vertical cabinet 202. The door 204 may enable a user or a user tool, like a robotic arm, to add labware to the stack stored within the vertical cabinet 202 or remove labware from the vertical cabinet 202.Docket No. 0082-0034PCT1

[0051] With continued reference to FIG. 2, a leveling foot 206 may be positioned at the bottom of the equipment handling module 200 beneath the vertical cabinet 202. The leveling foot 206 may be configured to support a portion of the weight of the equipment handling module 200 and provide stability on various supporting surfaces. In some cases, the leveling foot 206 may be a spring-loaded leveling foot that enables self-leveling of the equipment handling module 200 without requiring manual adjustment by a user. The spring of the leveling foot 206 may be sufficiently strong to support at least a portion of the weight of the equipment handling module 200, with the remainder of the weight being borne by the liquid handling system through a mounting connection.

[0052] A mounting platform 208 may be positioned at a distal end of a platen 212 of the equipment handling module 200. The mounting platform 208 may be configured to pass through an opening in an enclosure of the pipette system to deliver labware into the enclosure. The mounting platform 208 may feature a flat surface with multiple mounting holes 210 arranged in a pattern. The mounting holes 210 may be configured to receive fasteners for securing the equipment handling module 200 to a deck of the liquid handling system. In some cases, the fasteners may include spring-loaded captive screws that protrude from the mounting platform 208 when in an unfastened state and compress to become flush with a housing of the mounting platform 208 when properly installed, providing a visible indicator of proper installation. The mounting platform 208 may include labware locating features 220 that allow the liquid handling system to place labware in the same deck slot where the equipment handling module 200 has been attached.

[0053] The platen 212 may extend horizontally from a base of the vertical cabinet 202. The platen 212 may provide a pathway for transporting labware from the vertical cabinet 202 into the enclosure of the pipette system. The platen 212 may include structural support elements and mounting features along a length of the platen 212.

[0054] As further shown in FIG. 2, z-axis rails 214 may be positioned within the vertical cabinet 202 adjacent to the platen 212. The z-axis rails 214 may provide linear guidance for vertical movement of a z-axis carriage within the vertical cabinet 202. The z-axis rails 214 may enable precise vertical positioning of a labware platform during transfer operations from the stack of labware to a horizontal transport system.

[0055] An x-axis carriage 216 may be positioned on the platen 212. The x-axis carriage 216 may be configured to transport labware horizontally along the platen 212 and into the enclosure ofDocket No. G082-0034PCT1the liquid handling system. The x-axis carriage 216 may include mechanical components that enable precise linear motion along a horizontal axis.

[0056] An x-axis rail 218 may extend along the platen 212. The x-axis rail 218 may provide a linear guide track for the x-axis carriage 216 during horizontal movement operations. The x-axis rail 218 may enable precise linear motion of the x-axis carriage 216 into the enclosure of the pipette system, facilitating accurate positioning of labware within the liquid handling system without requiring calibration.

[0057] Referring to FIG. 3, an equipment handling module 300 may be configured to interface with a liquid handling system. The equipment handling module 300 may include a cabinet 302 positioned at an upper portion of the equipment handling module 300. The cabinet 302 may be configured to store a stack of labware. The cabinet 302 may feature an elongated rectangular housing with a viewing window on a front face of the cabinet 302. The viewing window may have an arched top profile and may allow visual observation of labware stored within the cabinet 302. The cabinet 302 may include multiple fastening points arranged along exterior surfaces of the cabinet 302, which may facilitate secure assembly of cabinet panels.

[0058] A door 304 may be positioned on a side of the cabinet 302. The door 304 may provide access to an interior of the cabinet 302 for loading labware into the equipment handling module 300. The door 304 may feature a rectangular profile and may be configured to seal the cabinet 302 during operation. The door may be designed to allow for human or robotic loading of labware into the cabinet 302.

[0059] With continued reference to FIG. 3, the cabinet 302 may be supported by a shuttle module 306 positioned beneath the cabinet 302. The shuttle module 306 may provide structural support and may house mechanical components associated with z-axis and x-axis carriage systems. The shuttle module 306 may include a rectangular housing with access panels and connection ports visible on exterior surfaces of the shuttle module 306.

[0060] A leveling foot 308 may extend downward from the shuttle module 306 at one end of the equipment handling module 300. The leveling foot 308 may be configured to support a portion of a weight of the equipment handling module 300 and provide stability on various supporting surfaces including surfaces that are not level. In some cases, the leveling foot 308 may be a spring-loaded leveling foot that enables self-leveling of the equipment handling module 300 without requiring manual adjustment by a user.Docket No. G082-0034PCT1

[0061] A mounting component 310 may extend horizontally from the shuttle module 306. The mounting component 310 may be configured to pass through an opening in an enclosure of a pipette system to deliver labware into the enclosure. The mounting component 310 may include multiple mounting apertures 312 positioned along a length of the mounting component 310. The mounting apertures 312 may be configured to receive fasteners for securing the equipment handling module 300 to a deck of the liquid handling system. As shown in FIG. 3, four mounting apertures 312 are arranged in a pattern along the mounting component 310. In some cases, the fasteners may include spring-loaded captive screws that protrude from the mounting component 310 when in an unfastened state and compress to become flush with a housing of the mounting component 310 when properly fastened, providing a visible indicator of proper installation.

[0062] An x-axis component 314 may be positioned on the mounting component 310. The x-axis component 314 may be configured to transport labware horizontally along the mounting component 310 and into the enclosure of the liquid handling system. The x-axis component 314 may include mechanical elements that enable precise linear motion along a horizontal axis.

[0063] A linear guide rail 316 may extend along a length of the mounting component 310. The linear guide rail 316 may provide a track for horizontal movement of the x-axis component 314. The linear guide rail 316 may enable precise linear motion of the x-axis component 314 into the enclosure of the pipette system, facilitating accurate positioning of labware within the liquid handling system without requiring calibration.

[0064] As further shown in FIG. 3, an adjacent module mounting 318 may be visible on a side of the cabinet 302. The adjacent module mounting 318 may provide a connection interface for positioning multiple equipment handling modules side by side. In some cases, the equipment handling module 300 may be configured to position up to four modules adjacent to each other to serve a single liquid handling system, enabling increased capacity and flexibility for different types of labware. The adjacent module mounting 318 may enable the equipment handling modules to share a common base structure while maintaining individual functionality for storing and dispensing labware into the enclosure of the pipette system. Adjacent module mounting 318 may be used to place a casing on the cabinet 302 including customizable casings mounted onto the cabinet 302.

[0065] Referring to FIG. 4, an equipment handling module assembly 400 may be configured to interface with a liquid handling system. The equipment handling module assembly 400 mayDocket No. 0082-0034PCT1comprise multiple vertical cabinets 402 arranged in a side-by-side configuration. As shown in FIG.4, three vertical cabinets 402 are visible, each vertical cabinet 402 featuring an elongated rectangular housing with viewing windows on a front face. The viewing windows may have an arched top configuration and may allow visual observation of labware 406 stored within each vertical cabinet 402. The vertical cabinets 402 may be positioned in parallel alignment, sharing a common base structure that provides structural support for the equipment handling module assembly 400. A number of modules can be attached as to fill all side deck slots. Any configuration can be used, including removing a module in a second slot, the middle one shown here. Other types of modules may also be connected to the slots to perform other functions or operations in conjunction with the operations of the liquid handling system.

[0066] The labware 406 may be visible through the viewing windows of the vertical cabinets 402. The labware 406 may appear as stacked rectangular containers that rest on top of the adjacent labware 406. The labware 406 may be stored in stacks within each vertical cabinet 402, with multiple pieces of labware 406 arranged vertically within each cabinet interior. In some cases, the labware 406 may include tip racks, PCR plates, deep well plates, reagent reservoirs, and other laboratory equipment.

[0067] With continued reference to FIG. 4, a mounting assembly 404 may be positioned at a lower portion of the equipment handling module assembly 400. The mounting assembly 404 may include a rectangular housing with tubing or conduit elements extending from the mounting assembly 404. The tubing or conduit elements may provide electrical, pneumatic, or data connectivity for the equipment handling module assembly 400. The mounting assembly 404 may be connected to the base structure of the vertical cabinets 402 and may provide an interface for connecting the equipment handling module assembly 400 to external systems.

[0068] The base structure of the equipment handling module assembly 400 may include a horizontal platform that extends beneath the vertical cabinets 402. The horizontal platform may provide a mounting surface for connecting to a deck of the liquid handling system. The base structure may feature multiple panel sections and may include mounting features that facilitate secure attachment to the pipette system. A leveling foot may be visible at a lower portion of the equipment handling module assembly 400, the leveling foot being configured to support a portion of the weight of the equipment handling module assembly 400 and provide stability on various supporting surfaces.Docket No. G082-0034PCT1

[0069] The configuration of multiple vertical cabinets 402 arranged in parallel may enable feeding of different types of labware 406 to the liquid handling system. In some cases, the equipment handling module assembly 400 may provide increased capacity for protocols requiring greater amounts of labware 406 than would be possible without such modules. The equipment handling module assembly 400 may allow a user to run a protocol that uses more labware 406 than would fit within the enclosure of the pipette system at one time.

[0070] In some cases, the equipment handling module assembly 400 may be configured to use the x-axis carriage to both insert labware 406 into the enclosure of the pipette system and remove labware 406 from the enclosure back into the vertical cabinet 402. This configuration may enable the liquid handling system to use labware 406 from multiple modules. In some cases, waste or extra labware 406 may be removed through one of the modules and stored in a second module or ejected from the enclosure of the liquid handling system. The use of multiple vertical cabinets 402 may allow the liquid handling system to have increased capacity and additional functionality or flexibility to use labware 406 that may not fit within the enclosure all at once.

[0071] Referring to FIG. 5, an equipment handling module 500 may be configured to interface with a liquid handling system. The equipment handling module 500 is shown isolated from the liquid handling system, depicting the relationship between a vertical cabinet 502 and a shuttle module 506 that extends from a base of the vertical cabinet 502.

[0072] The vertical cabinet 502 may be positioned at an upper portion of the equipment handling module 500. The vertical cabinet 502 may feature an enclosed rectangular housing configured to store a stack of labware. The vertical cabinet 502 may include structural frame members that define a storage area for stacked labware within the equipment handling module 500. In some cases, the vertical cabinet 502 may be configured to receive and hold multiple pieces of labware arranged in a stacked configuration, with the labware including tip racks, PCR plates, deep well plates, reagent reservoirs, and other laboratory equipment.

[0073] With continued reference to FIG. 5, a support structure 504 may be positioned beneath the vertical cabinet 502. The support structure 504 may provide structural support for the vertical cabinet 502. The support structure 504 may connect the vertical cabinet 502 to the shuttle module 506. In some cases, the support structure 504 may house mechanical components associated with z-axis and x-axis carriage systems.Docket No. 0082-0034PCT1

[0074] The shuttle module 506 may extend horizontally from the support structure 504. The shuttle module 506 may provide a pathway for transporting labware from the vertical cabinet 502 into an enclosure of a pipette system. The shuttle module 506 may include a flat surface that supports an x-axis carriage 512 during transport operations.

[0075] A mounting component 508 may be positioned at a left end of the shuttle module 506. The mounting component 508 may include a circuit board with electronic components and connectors that provide electrical connectivity and control signals for the equipment handling module 500. The mounting component 508 may interface with control systems of the liquid handling system to coordinate operation of the equipment handling module 500.

[0076] As further shown in FIG. 5, x-axis rails 510 may be positioned along a length of the shuttle module 506. The x-axis rails 510 may provide linear guidance for the x-axis carriage 512 during horizontal movement. The x-axis rails 510 may extend from the support structure 504 toward the mounting component 508. The x-axis rails 510 may enable precise linear motion of the x-axis carriage 512 into the enclosure of the pipette system.

[0077] The x-axis carriage 512 may be positioned on the x-axis rails 510. The x-axis carriage 512 may be configured to transport a labware platform 514 horizontally along the shuttle module 506 and into the enclosure of the liquid handling system. The x-axis carriage 512 may include mechanical components that enable precise linear motion along a horizontal axis.

[0078] The labware platform 514 may be positioned on the x-axis carriage 512. The labware platform 514 may be configured to receive and support labware 516 from the stack stored in the vertical cabinet 502. The labware platform 514 may feature a flat upper surface upon which the labware 516 rests during transport operations. The labware platform 514 may interface with both a z-axis carriage within the vertical cabinet 502 and the x-axis carriage 512 to enable transfer of labware from vertical movement to horizontal movement. The labware platform 514 may include an adapter to allow for the stacking of labware in the cabinet of the equipment handling module. With the top of the adapter of the labware platform 514 being designed so the specific labware, which may not be stackable or stable to be stacked, may rest upon it, and the bottom of the adapter or labware platform 514 is able to rest on other labware that is sitting in the cabinet. Additionally, this adapter of the labware platform 514 may be designed such that the latch mechanism described herein (for example the latch mechanism 1406 of FIG. 14) may catch and cause the adapter andDocket No. G082-0034PCT1labware platform to rest on the latch mechanism to hold up labware that the stacker may not normally be able to hold.

[0079] The labware 516 may be positioned on the labware platform 514 that may include an adapter or component to enable the length or height of tips, for example if the labware 516 includes a tip rack, in some examples, such as for a well plate, the labware 516 may rest directly on the x-axis carriage. The labware 516 may appear as a rectangular container with a grid pattern on an upper surface of the labware 516, representing equipment such as a tip rack or well plate. As shown in FIG. 5, the labware 516 is shown in a position along the x-axis extended from the vertical cabinet 502, demonstrating transport of labware from the vertical cabinet 502 along the x-axis and into or out of the enclosure of the liquid handling system. From this position at a distal end of the x-axis, a gripper arm or robotic element of the liquid handling system may move the labware 516 to another location on a deck of the liquid handling system. The mounting platform or deck of the liquid handling system may include labware locating features 518 that allow the liquid handling system to place labware in the same deck slot where the equipment handling module 500 has been attached.

[0080] Referring to FIG. 6, an equipment handling module 600 may be configured to interface with a liquid handling system. The equipment handling module 600 is shown in a side elevation view, revealing the relationship between a vertical cabinet 602 and a shuttle module 604 that extends from a base of the vertical cabinet 602.

[0081] The vertical cabinet 602 may be positioned at a right side of the equipment handling module 600. The vertical cabinet 602 may feature an enclosed rectangular housing configured to store labware 610. As shown in FIG. 6, multiple pieces of lab ware 610 are visible within the vertical cabinet 602, with five pieces of labware 610 arranged vertically in a stacked configuration within a cabinet interior. The vertical cabinet 602 may include structural frame members that define a storage area for the labware 610, with the labware 610 stacked within the vertical cabinet 602. In some cases, the vertical cabinet 602 may be taller or shorter than depicted in FIG. 6 to increase capacity or accommodate different space requirements, and therefore, the equipment handling module 600 may store more or fewer than five pieces of labware 610.

[0082] With continued reference to FIG. 6, the shuttle module 604 may extend horizontally from the base of the vertical cabinet 602 toward a left side of the equipment handling module 600. The shuttle module 604 may provide a pathway for transporting labware 610 from the verticalDocket No. G082-0034PCT1cabinet 602 into an enclosure of a pipette system. The shuttle module 604 may include aflat surface with structural support elements and may feature mechanical components arranged along a length of the shuttle module 604.

[0083] A labware platform 608 may be positioned on the shuttle module 604. The labware platform 608 may be configured to receive labware 610 from the stack within the vertical cabinet 602 and support the lab ware 610 during transport operations. The lab ware platform 608 may interface with both a z-axis carriage within the vertical cabinet 602 and an x-axis carriage 606 to enable transfer of lab ware 610 from vertical movement to horizontal movement. The labware platform 608 may include features such as pockets, recesses, and mounting surfaces that enable engagement with the z-axis carriage and the x-axis carriage 606 during transport operations.

[0084] As further shown in FIG. 6, the x-axis carriage 606 may be positioned on the shuttle module 604 adjacent to the labware platform 608. The x-axis carriage 606 may be configured to transport the labware platform 608 horizontally along the shuttle module 604 and into the enclosure of the liquid handling system. The x-axis carriage 606 may include mechanical components that enable linear motion along a horizontal axis.

[0085] At a left end of the shuttle module 604, a leveling foot may be positioned to provide support and stability for the equipment handling module 600. A base of the equipment handling module 600 may include motor assemblies and drive components positioned beneath the vertical cabinet 602 that provide mechanical force for moving the labware 610 along both vertical and horizontal axes. The motor assemblies may drive a z-axis carriage within the vertical cabinet 602 to raise and lower the labware platform 608 within the vertical cabinet 602, and may drive the x-axis carriage 606 to transport the labware platform 608 horizontally into the enclosure of the pipette system.

[0086] Referring to FIG. 7, an equipment handling module 700 may be configured to interface with a liquid handling system. The equipment handling module 700 is shown in a side elevation view, depicting the relationship between a shuttle module 702 and a horizontal axis rail 704 that extends from a lower region of the shuttle module 702.

[0087] The shuttle module 702 may be positioned at a right side of the equipment handling module 700. The shuttle module 702 may feature an enclosed rectangular housing configured to store a labware stack 714. The shuttle module 702 may include structural frame members that define a storage area and provide support for a cabinet assembly. The labware stack 714 may beDocket No. G082-0034PCT1visible within the shuttle module 702, showing multiple pieces of labware stacked vertically within a cabinet interior. The labware stack 714 may appear as rectangular containers with raised edges positioned one above another within the shuttle module 702. In some cases, the labware stack 714 may include tip racks, PCR plates, deep well plates, reagent reservoirs, and other laboratory equipment arranged in a stacked configuration. In some cases, the labware stack 714 may include a single piece of labware.

[0088] With continued reference to FIG. 7, the horizontal axis rail 704 may extend horizontally from a base of the shuttle module 702 toward a left side of the equipment handling module 700. The horizontal axis rail 704 may provide a pathway for transporting labware from the shuttle module 702 into an enclosure of a pipette system. The horizontal axis rail 704 may include a flat surface that supports movement of components along a horizontal axis.

[0089] An end position 706 may be indicated at a left terminus of the horizontal axis rail 704. The end position 706 may represent a location where a labware platform 708 is positioned when extended into the enclosure of the pipette system for interaction with robotic elements of the liquid handling system. The end position 706 may correspond to a hard stop location that enables repeatable and accurate positioning of labware without requiring calibration of the equipment handling module 700.

[0090] The labware platform 708 may be positioned on the horizontal axis rail 704 adjacent to the shuttle module 702. The labware platform 708 may be configured to receive labware from the labware stack 714 within the shuttle module 702 and support the labware during transport operations. The labware platform 708 may interface with both a z-axis carriage 712 within the shuttle module 702 and an x-axis carriage 710 to enable transfer of labware from vertical movement to horizontal movement.

[0091] As further shown in FIG. 7, the x-axis carriage 710 may be positioned on the horizontal axis rail 704. The x-axis carriage 710 may be configured to transport the labware platform 708 horizontally along the horizontal axis rail 704 and into the enclosure of the liquid handling system. The x-axis carriage 710 may include mechanical components that enable precise linear motion along a horizontal axis, facilitating accurate positioning of labware within the pipette system.

[0092] The z-axis carriage 712 may be positioned within the shuttle module 702. The z-axis carriage 712 may be configured to move vertically to interface with the labware platform 708. The z-axis carriage 712 may enable vertical movement of the labware platform 708 within the shuttleDocket No. G082-0034PCT1module 702 before transitioning to horizontal movement along the x-axis carriage 710 for delivery into the enclosure of the pipette system. The z-axis carriage 712 may include a first set of locating pins configured to engage with the labware platform 708 during vertical movement, and the x-axis carriage 710 may include a second set of locating pins configured to engage with the labware platform 708 during horizontal transport.

[0093] Referring to FIG. 8, an equipment handling system 800 may be configured to interface with an enclosure of a pipette system. The equipment handling system 800 is shown in a side elevation view, revealing the relationship between a shuttle module 802 and a horizontal axis module 804 that extends from a base of the shuttle module 802.

[0094] The shuttle module 802 may be positioned at a right side of the equipment handling system 800. Though shown and described herein at one particular side (e.g., the right side), in some examples the equipment handling module may be connected at a front, back, or left side of the liquid handling system. The shuttle module 802 may feature an enclosed rectangular housing configured to store labware. The shuttle module 802 may include structural frame members that define a storage area, with a latch 812 visible at an upper portion of the shuttle module 802. The latch 812 may be configured to retain a stack of labware within the shuttle module 802 and release individual pieces of labware onto a labware platform 808 for transport into the enclosure of the pipette system. In some cases, the latch 812 may include support arms that pivot between a retaining position and a release position to control the release of labware from the stack.

[0095] Labware 814 may be shown positioned within the shuttle module 802 adjacent to the latch 812. The labware 814 may appear as a rectangular container with a raised upper portion, representing laboratory equipment such as a tip rack, well plate, or similar consumable item stored within the shuttle module 802.

[0096] With continued reference to FIG. 8, the horizontal axis module 804 may extend horizontally from the base of the shuttle module 802 toward a left side of the equipment handling system 800. The horizontal axis module 804 may provide a pathway for transporting labware from the shuttle module 802 into the enclosure of the pipette system. The horizontal axis module 804 may include a flat surface with structural support elements and may feature a series of mounting elements arranged along a length of the horizontal axis module 804.

[0097] The labware platform 808 may be positioned on the horizontal axis module 804. The labware platform 808 may be configured to receive labware from the shuttle module 802 andDocket No. 0082-0034PCT1support the labware during transport operations. The labware platform 808 may interface with both a z-axis carriage within the shuttle module 802 and an x-axis carriage 810 to enable transfer of labware from vertical movement to horizontal movement.

[0098] The x-axis carriage 810 may be positioned on the horizontal axis module 804 adjacent to the labware platform 808. The x-axis carriage 810 may be configured to transport the labware platform 808 horizontally along the horizontal axis module 804 and into the enclosure of the liquid handling system.

[0099] A horizontal position 806 may be indicated at a left end of the horizontal axis module 804. The horizontal position 806 may represent an extended position where the labware platform 808 is presented to robotic elements of the pipette system within the enclosure. The horizontal position 806 may correspond to a hard stop location that enables repeatable and accurate positioning of labware without requiring calibration of the equipment handling system 800.

[0100] As further shown in FIG. 8, the x-axis carriage 810 may include a positioning system that enables accurate and repeatable placement of the labware platform 808 at the horizontal position 806. The positioning system may include a hard stop positioned at the horizontal position 806 and a lead screw nut coupled to a drive mechanism for the x-axis carriage 810. As the x-axis carriage 810 approaches the horizontal position 806, the x-axis carriage 810 may first bottom out and physically contact the hard stop. The lead screw nut may continue to move approximately 2mm past the point where the x-axis carriage 810 contacts the hard stop, compressing springs associated with the positioning system. The compression of the springs may preload the x-axis carriage 810 against the hard stop, ensuring that the x-axis carriage 810 is positioned with a biasing force against the hard stop and is therefore accurately positioned each time the x-axis carriage 810 enters the enclosure of the liquid handling system.

[0101] In some cases, the equipment handling system 800 may include a detection flag attached to the lead screw nut. The detection flag may be configured to trigger an end stop sensor after the x-axis carriage 810 has bottomed out against the hard stop and the springs are compressed. The end stop sensor may provide a signal to a control system indicating that the x-axis carriage 810 has reached the horizontal position 806 and is properly preloaded against the hard stop. The preloading of the lead screw may ensure that the x-axis carriage 810 is positioned with a biasing force against the hard stop, and the force of the preloading may be sufficient to ensure contact with the hard stop but not to deform the hard stop.Docket No. 0082-0034PCT1

[0102] Referring to FIG. 9, a shuttle module 900 may be configured to transfer a labware platform 904 between a z-axis carriage 906 and an x-axis carriage 910 within an equipment handling module. The shuttle module 900 may show mechanical components involved in transitioning labware from vertical movement within a vertical cabinet to horizontal movement for delivery into an enclosure of a pipette system.

[0103] Labware equipment 902 may be positioned at an upper portion of the shuttle module 900. The labware equipment 902 may include vertical support members that extend upward. The labware equipment 902 may provide structural support for the shuttle module 900 and may define a storage area for stacked labware within the equipment handling module.

[0104] With continued reference to FIG. 9, the labware platform 904 may be positioned adjacent to the z-axis carriage 906. The labware platform 904 may be configured to receive and support labware from a stack stored in the vertical cabinet. The labware platform 904 may feature a flat rectangular surface with multiple openings and mounting features. The labware platform 904 may interface with both the z-axis carriage 906 and the x-axis carriage 910 to enable transfer of labware from vertical movement to horizontal movement. In some cases, the labware platform 904 may connect to the z-axis carriage 906 and the x-axis carriage 910 via magnets that secure the labware platform 904 against locating pins. The magnets may be positioned to pull the labware platform 904 down onto respective carriage surfaces to maintain accurate positioning during vertical and horizontal movement.

[0105] The z-axis carriage 906 may be positioned within the labware equipment 902. The z-axis carriage 906 may be configured to move vertically to interface with the labware platform 904. The z-axis carriage 906 may include mechanical components that enable precise vertical movement within the vertical cabinet. A z-axis motion component 908 may be positioned adjacent to the z-axis carriage 906. The z-axis motion component 908 may provide a driving mechanism for vertical movement of the z-axis carriage 906.

[0106] As further shown in FIG. 9, the x-axis carriage 910 may be positioned below the labware platform 904. The x-axis carriage 910 may be configured to receive the labware platform 904 from the z-axis carriage 906 when the z-axis carriage 906 reaches a bottom position of travel. The z-axis carriage 906 may have a U-shape that surrounds or partially surrounds the shape of the x-axis carriage, for example with a base of the U-shape positioned opposite the direction of travel of the x-axis carriage 910 as shown in FIG. 17. The x-axis carriage 910 may include mechanicalDocket No. 0082-0034PCT1components that enable precise horizontal movement along an x-axis for transporting labware into the enclosure of the pipette system.

[0107] Spring-loaded pins 912 may be positioned at multiple locations within the shuttle module 900. As shown in FIG. 9, three spring-loaded pins 912 are visible, positioned adjacent to the labware platform 904 and the x-axis carriage 910. The spring-loaded pins 912 may be configured to disengage the labware platform 904 from the z-axis carriage 906 as the z-axis carriage 906 lowers to the bottom position. The spring-loaded pins 912 may provide a temporary support surface for the labware platform 904 during the transition between the z-axis carriage 906 and the x-axis carriage 910. In some cases, a spring force of the spring-loaded pins 912 may be configured to be stronger than a magnetic force of magnets on the z-axis carriage 906, enabling the spring-loaded pins 912 to push the labware platform 904 off locating pins and magnets of the z-axis carriage 906 during the handoff to the x-axis carriage 910.

[0108] X-axis rails 914 may be positioned at a lower portion of the shuttle module 900. The x-axis rails 914 may extend horizontally along a length of the shuttle module 900. The x-axis rails 914 may provide linear guidance for the x-axis carriage 910 during horizontal movement, ensuring stable and accurate horizontal positioning of the lab ware platform 904 as the lab ware platform 904 is transported into the enclosure of the pipette system.

[0109] Alignment pins 916 may be positioned at multiple locations on the labware equipment 902 and the labware platform 904. As shown in FIG. 9, three alignment pins 916 are visible, positioned at an upper portion of the shuttle module 900 adjacent to the labware equipment 902. The alignment pins 916 may be configured to engage with corresponding features on the labware platform 904 during vertical and horizontal movement, ensuring precise positioning of the labware platform 904 relative to the carriages and enabling accurate and repeatable placement of labware within the liquid handling system.

[0110] Referring to FIG. 10, a shuttle module 1000 may be configured to transfer a labware platform 1004 between a z-axis carriage 1008 and an x-axis carriage within an equipment handling module. The section view of FIG. 10 reveals internal components and spatial relationships during the transition from vertical movement to horizontal movement.[OHl] The shuttle module 1000 may include labware equipment 1002 positioned at an upper right portion of the shuttle module 1000. The labware equipment 1002 may extend vertically and may provide structural support for the shuttle module 1000.Docket No. 0082-0034PCT1

[0112] With continued reference to FIG. 10, the labware platform 1004 may be positioned in a central region of the shuttle module 1000. The labware platform 1004 may be configured to receive and support labware during transport operations. The labware platform 1004 may feature a flat rectangular configuration with a horizontal upper surface. Two ledges 1006 may be positioned on opposite sides of the labware platform 1004. The ledges 1006 may extend from the labware platform 1004 and may be configured to interface with support structures within the vertical cabinet.

[0113] The z-axis carriage 1008 may be positioned below the lab ware platform 1004. The z-axis carriage 1008 may be configured to move vertically to interface with the labware platform 1004. The z-axis carriage 1008 may include mechanical components that enable precise vertical movement within the vertical cabinet.

[0114] A z-axis motion component 1010 may be positioned at a lower right portion of the shuttle module 1000. The z-axis motion component 1010 may be coupled to the z-axis carriage 1008. The z-axis motion component 1010 may provide a driving force for vertical movement of the z-axis carriage 1008 within the shuttle module 1000.

[0115] As further shown in FIG. 10, two spring-loaded pins 1012 may be positioned on opposite sides of the shuttle module 1000, adjacent to the labware platform 1004. The spring-loaded pins 1012 may be configured to support the lab ware platform 1004 during the transition between the z-axis carriage 1008 and the x-axis carriage. Each spring-loaded pin 1012 may include a collar 1014 positioned along a length of the spring-loaded pin 1012. The collars 1014 may provide a shoulder surface that interfaces with adjacent structural elements during compression of the spring-loaded pins 1012.

[0116] Each spring-loaded pin 1012 may terminate in a pin end 1016 at an upper extremity of the spring-loaded pin 1012. As shown in FIG. 10, two pin ends 1016 are visible, one associated with each spring-loaded pin 1012. The pin ends 1016 may be configured to engage with corresponding pockets or recesses in the labware platform 1004, providing temporary support for the labware platform 1004 as the z-axis carriage 1008 lowers to a bottom position of travel. The labware platform 1004 may include pockets that loosely receive the spring-loaded pins 1012 with clearance, allowing the labware platform 1004 to rest on top of the pin ends 1016 during the transition between the z-axis carriage 1008 and the x-axis carriage.Docket No. G082-0034PCT1

[0117] The z-axis carriage 1008 may include a shoulder feature that contacts the spring-loaded pins 1012 to retract the spring-loaded pins 1012 as the z-axis carriage 1008 continues to lower past a handoff position. The spring-loaded pins 1012 may be configured to compress as the z-axis carriage 1008 continues to lower, causing the pin ends 1016 to disengage from the labware platform 1004 and enabling the labware platform 1004 to engage with the x-axis carriage for horizontal transport into the enclosure of the pipette system.

[0118] Referring to FIG. 11, a shuttle module 1100 may be configured to interface with an enclosure of a pipette system. The shuttle module 1100 is shown in a front elevation view, depicting the relationship between vertical and horizontal transport components within the equipment handling module.

[0119] The shuttle module 1100 may include labware equipment 1102 positioned at an upper portion of the shuttle module 1100. The labware equipment 1102 may feature a rectangular housing with a railing structure at a top of the labware equipment 1102 and a flat front panel. A small rectangular element may be visible on a front face of the labware equipment 1102, which may serve as a viewing window or access point for observing contents stored within the shuttle module 1100.

[0120] With continued reference to FIG. 11, a lab ware platform 1104 may be positioned below the labware equipment 1102. The labware platform 1104 may be configured to receive and support labware from a stack stored within the shuttle module 1100. The labware platform 1104 may interface with both a z-axis carriage 1110 and an x-axis carriage 1108 to enable transfer of labware from vertical movement to horizontal movement.

[0121] A ledge 1106 may be positioned adjacent to the labware platform 1104. The ledge 1106 may provide a support surface at an interface between the labware equipment 1102 and lower components of the shuttle module 1100. The ledge 1106 may define a transition region where the labware platform 1104 is handed off between the z-axis carriage 1110 and the x-axis carriage 1108.

[0122] The x-axis carriage 1108 may be positioned below the labware platform 1104 and the ledge 1106. The x-axis carriage 1108 may be configured to receive the labware platform 1104 and transport the labware platform 1104 horizontally into the enclosure of the pipette system. The x-axis carriage 1108 may include a flat surface with structural support elements that enable precise horizontal movement along a horizontal component 1114.Docket No. 0082-0034PCT1

[0123] As further shown in FIG. 11, the z-axis carriage 1110 may be positioned beneath the x-axis carriage 1108. The z-axis carriage 1110 may be configured to move vertically within the shuttle module 1100 to interface with the labware platform 1104. The z-axis carriage 1110 may include mechanical components that enable vertical movement for lowering labware from the stack onto the x-axis carriage 1108. The z-axis carriage 1110 may include a first set of locating pins configured to engage with the labware platform 1104 during vertical movement, and the x-axis carriage 1108 may include a second set of locating pins configured to engage with the labware platform 1104 during horizontal transport.

[0124] A z-axis motion component 1112 may be positioned at a lower right portion of the shuttle module 1100 adjacent to a vertical support structure. The z-axis motion component 1112 may provide a mechanical drive system for moving the z-axis carriage 1110 vertically within the shuttle module 1100. The z-axis motion component 1112 may include a motor and associated drive elements that enable precise vertical positioning of the z-axis carriage 1110 and the labware platform 1104. The z-axis motion component 1112 may include lead screws, linear actuators, and other such hardware or components.

[0125] The horizontal component 1114 may extend from a base of the shuttle module 1100 toward a left side of the shuttle module 1100. The horizontal component 1114 may provide a pathway for transporting labware from the shuttle module 1100 into the enclosure of the pipette system. The horizontal component 1114 may include structural support elements along a length of the horizontal component 1114 and may support the x-axis carriage 1108 during horizontal transport operations. In some cases, the horizontal component 1114 may include linear guide rails that provide precise linear guidance for the x-axis carriage 1108 as the x-axis carriage 1108 transports the labware platform 1104 into the enclosure of the pipette system.

[0126] Referring to FIG. 12, a shuttle module 1200 may be configured to interface with a liquid handling system. The shuttle module 1200 is shown in a front elevation view with internal components visible, depicting the relationship between a vertical storage area and a horizontal transport mechanism.

[0127] The shuttle module 1200 may include labware equipment 1202 positioned on the left side of the shuttle module 1200. The labware equipment 1202 may appear as a rectangular container with a raised upper portion, representing a piece of labware such as a tip rack or well plate that is stored within a vertical cabinet portion of the shuttle module 1200.Docket No. 0082-0034PCT1

[0128] With continued reference to FIG. 12, a z-axis carriage 1204 may be positioned at a right side of the shuttle module 1200. The z-axis carriage 1204 may be configured to move vertically within the shuttle module 1200. The z-axis carriage 1204 may interface with a labware platform 1212 to enable vertical movement of labware within the vertical cabinet. The z-axis carriage 1204 may be guided by z-axis rails 1206, which may extend vertically along the right side of the shuttle module 1200. The z-axis rails 1206 may provide linear guidance for the z-axis carriage 1204 during vertical movement, ensuring stable and accurate vertical positioning.

[0129] Horizontal rails 1208 may extend horizontally across a lower portion of the shuttle module 1200. The horizontal rails 1208 may provide a track for horizontal movement of components along an x-axis, enabling transport of labware from the vertical cabinet into an enclosure of a pipette system.

[0130] An x-axis carriage 1210 may be positioned on the horizontal rails 1208 at the left side of the shuttle module 1200 beneath the labware equipment 1202. The x-axis carriage 1210 may be configured to receive the labware platform 1212 from the z-axis carriage 1204 and transport the labware platform 1212 horizontally along the horizontal rails 1208 into the enclosure of the pipette system.

[0131] As further shown in FIG. 12, the labware platform 1212 may be positioned on the x-axis carriage 1210 and may support the labware equipment 1202. The labware platform 1212 may be configured to interface with both the z-axis carriage 1204 and the x-axis carriage 1210 to enable transfer of labware from vertical movement to horizontal movement.

[0132] A latch 1214 may be positioned at an upper right portion of the shuttle module 1200 adjacent to the z-axis rails 1206. The latch 1214 may be configured to retain a stack of labware within the vertical cabinet and release individual pieces of labware onto the labware platform 1212 for transport. The latch 1214 may include support arms that pivot between a retaining position and a release position to control the release of labware from the stack stored within the shuttle module 1200.

[0133] A rod 1216 may extend vertically within the shuttle module 1200, with two instances of the rod 1216 visible in FIG. 12. The rods 1216 may be positioned on opposite sides of the vertical cabinet area and may be associated with the latch 1214 mechanism that controls the release of labware from the stack. The support arms of the latch 1214 may include a bushing connection to the rod 1216 that extends from a bottom of the vertical cabinet to a top of the vertical cabinet.Docket No. 0082-0034PCT1Rotation of the rod 1216 may cause the support arms of the latch 1214 to pivot between the retaining position and the release position.

[0134] A rotation component 1218 may be positioned at a lower portion of the shuttle module 1200 adjacent to the horizontal rails 1208. The rotation component 1218 may be associated with an actuation mechanism that drives movement of the latch 1214 and the rods 1216 to control the release of labware from the stack stored within the shuttle module 1200. The rotation component 1218 may provide rotational input to the rods 1216, which in turn may cause the support arms of the latch 1214 to pivot between the retaining position and the release position.

[0135] Referring to FIG. 13, a labware platform 1300 may be configured to receive and support labware within an equipment handling system. The labware platform 1300 may be a flat, rectangular component designed to interface with both a z-axis carriage and an x-axis carriage during transfer operations between vertical and horizontal movement within the equipment handling module.

[0136] The labware platform 1300 may include a platform body 1302 that forms a main structural element of the labware platform 1300. The platform body 1302 may feature a generally rectangular shape with a flat upper surface configured to support labware during transport operations. The platform body 1302 may include raised edge portions along a perimeter of the platform body 1302 that provide structural rigidity and define boundaries of a labware support area.

[0137] With continued reference to FIG. 13, four corners 1304 may be positioned at each corner of the labware platform 1300 and may enable the labware to be stacked on top of the corners 1304 accurately and positioned in a known position on the deck of the liquid handling system. The corners 1304 may feature a stepped or notched profile that accommodates geometry of the vertical cabinet and associated mechanical components. The comers 1304 may provide clearance for structural elements of the equipment handling module while maintaining an overall rectangular footprint of the labware platform 1300.

[0138] Multiple side notches 1306 may be positioned along edges of the platform body 1302. The side notches 1306 may be recessed areas cut into sides of the platform body 1302. The side notches 1306 may be configured to provide clearance for support arms or latch mechanisms that retain a stack of labware within the vertical cabinet. As shown in FIG. 13, four side notches 1306 are visible, distributed along longer edges of the platform body 1302.Docket No. G082-0034PCT1

[0139] A pair of magnets 1308 may be positioned on the platform body 1302. The magnets 1308 may be elongated oval-shaped elements recessed into a surface of the platform body 1302. Each magnet 1308 may include three circular openings arranged in a linear pattern. The magnets 1308 may be configured to magnetically engage with corresponding magnet attractors on the z-axis carriage and the magnets 1310 may be configured to magnetically engage with corresponding magnet attractors on the x-axis carriage to secure the labware platform 1300 during vertical and horizontal movement, respectively. In some cases, the magnet attractors on the z-axis carriage may be made of tool steel that interfaces with the magnets 1308 to secure the lab ware platform 1300 during vertical movement.

[0140] As further shown in FIG. 13, additional magnets 1310 may be positioned on the platform body 1302 adjacent to the magnets 1308. The magnets 1310 may be smaller circular elements that provide additional magnetic engagement points for securing the labware platform 1300 to the carriages during transport operations. In some cases, the x-axis carriage may include magnet attractors positioned to interface with the magnets 1310 on the labware platform 1300, where the magnet attractors on the x-axis carriage may be offset from the magnet attractors on the z-axis carriage to accommodate space constraints while maintaining proper locating pin alignment.

[0141] Multiple locating pin pockets 1312 may be distributed across the platform body 1302. The locating pin pockets 1312 may be circular recesses configured to receive locating pins from the z-axis carriage and the x-axis carriage. As shown in FIG. 13, locating pin pockets 1312 are visible, positioned at various locations on the platform body 1302. The locating pin pockets 1312 may ensure accurate positioning of the labware platform 1300 relative to the carriages during a handoff operation between vertical and horizontal movement. In some cases, a first set of locating pin pockets 1312 may be configured to receive locating pins from the z-axis carriage during vertical movement, and a second set of locating pin pockets 1312 may be configured to receive locating pins from the x-axis carriage during horizontal transport.

[0142] A pair of pin pockets 1314 may be positioned on the platform body 1302. The pin pockets 1314 may be elongated recesses configured to receive corresponding alignment features from the carriages. The pin pockets 1314 may be configured to receive pins from the x-axis carriage rather than the z-axis carriage. The pin pockets 1314 may provide additional alignment capability to ensure proper orientation of the lab ware platform 1300 during transfer operations between the z-axis carriage and the x-axis carriage.Docket No. 0082-0034PCT1

[0143] Referring to FIG. 14, a latch mechanism 1400 may be configured to retain and release labware within a vertical cabinet 1402 of an equipment handling module. The latch mechanism 1400 may be positioned at an interface between the vertical cabinet 1402 and a labware platform area, showing mechanical components involved in controlling the release of labware from a stack stored within the vertical cabinet 1402.

[0144] The vertical cabinet 1402 may be shown at a right portion of the latch mechanism 1400. The vertical cabinet 1402 may feature vertical support members that extend upward. The vertical cabinet 1402 may provide structural support for the latch mechanism 1400 and may define a storage area for stacked labware within the equipment handling module. Multiple fastening points may be visible along the vertical cabinet 1402, which may facilitate secure assembly of cabinet panels.

[0145] With continued reference to FIG. 14, a z-axis rail 1404 may be positioned adjacent to the vertical cabinet 1402. The z-axis rail 1404 may extend vertically along a cabinet structure of the vertical cabinet 1402. The z-axis rail 1404 may provide linear guidance for vertical movement of components within the vertical cabinet 1402, enabling precise positioning of the labware platform during vertical travel.

[0146] A latch 1406 may extend from the vertical cabinet 1402. The latch 1406 may be configured to pivot between a retaining position and a release position. The latch 1406 may feature an elongated body that engages with labware to support a stack of labware within the vertical cabinet 1402. The latch 1406 may be coupled to a pivot mechanism that enables lateral movement between the retaining position and the release position. In some examples, the latch 1406 may instead be replaced by tabs on cams 1408 that extend to contact the sides of the labware rather than having the latch 1406 extending between the cams 1408. In such a configuration, there may be two cams 1408 on each of the opposing sides of the labware for a total of four tabs from the cams 1408 that contact and secure the labware.

[0147] As further shown in FIG. 14, two cams 1408 may be visible, positioned on opposite sides of the latch mechanism 1400. Each cam 1408 may be coupled to the latch 1406. Each cam 1408 may be configured to drive a pivoting motion of the latch 1406. The cams 1408 may convert rotational motion into lateral pivoting movement of the latch 1406, enabling controlled release of labware from the stack.Docket No. 0082-0034PCT1

[0148] Rotating rods 1410 may be positioned within the latch mechanism 1400. The rotating rods 1410 may extend vertically along sides of the latch mechanism 1400. As shown in FIG. 14, two rotating rods 1410 are visible, one on each side of the latch mechanism 1400. The rotating rods 1410 may be coupled to the cams 1408. The rotating rods 1410 may provide a rotational axis for actuating the pivoting motion of the latch 1406. The rotating rods 1410 may transmit rotational motion from a drive system to the cams 1408, which in turn may pivot the latch 1406 between the retaining position and the release position.

[0149] The configuration of the latch mechanism 1400 may enable controlled release of individual pieces of labware from the stack stored in the vertical cabinet 1402 onto a labware platform positioned below the latch 1406 for subsequent transport into an enclosure of a pipette system. In some cases, the latch mechanism 1400 may include support arms that are approximately nine millimeters wide on each side of the vertical cabinet 1402. The narrow width of the support arms may enable multiple equipment handling modules to be positioned adjacent to each other while maintaining a narrow footprint, allowing up to four equipment handling modules to be arranged side by side to serve a single liquid handling system. Furthermore, the motor for turning the rotating rods 1410 and the cams 1408 is below the cabinet such that the equipment handling module is maintained with as narrow or thin of a footprint as possible to enable multiple modules to be installed next to one another to serve the liquid handling system.

[0150] Referring to FIG. 15, a latch mechanism 1500 may be configured to retain and release labware within a vertical cabinet of an equipment handling module. The latch mechanism 1500 may show mechanical components involved in controlling a pivoting motion of support arms that engage with labware stored in a stack within the vertical cabinet.

[0151] Two rotating rods 1502 may extend vertically through the latch mechanism 1500, positioned on opposite sides of the latch mechanism 1500. The rotating rods 1502 may provide a rotational axis for actuating the support arms that retain labware within the vertical cabinet. Each rotating rod 1502 may be coupled to a cam and follower system that converts rotational motion into lateral pivoting movement of the support arms.

[0152] With continued reference to FIG. 15, a cam 1504 may be positioned adjacent to each rotating rod 1502. Two cams 1504 are visible in FIG. 15, one on each side of the latch mechanism 1500. Each cam 1504 may be mounted on a respective rotating rod 1502. Each cam 1504 may beDocket No. G082-0034PCT1configured to drive the pivoting motion of the support arms through engagement with a corresponding follower 1506.

[0153] A follower 1506 may be positioned adjacent to each cam 1504. Two followers 1506 are visible in FIG. 15, one on each side of the latch mechanism 1500. Each follower 1506 may be configured to engage with the corresponding cam 1504 and translate rotational motion of the cam 1504 into linear or pivoting motion for actuating the support arms.

[0154] As further shown in FIG. 15, a slot 1508 may be formed in each follower 1506. Two slots 1508 are visible in FIG. 15, one in each follower 1506. The slots 1508 may provide a guided pathway for the cam 1504 to engage with the follower 1506, enabling controlled translation of rotational motion into a desired movement of the support arms.

[0155] A rack 1510 may be positioned at a lower central portion of the latch mechanism 1500. The rack 1510 may extend horizontally and may feature a series of teeth along a length of the rack 1510. The rack 1510 may be configured to engage with a pinion 1512 to convert rotational motion from a motor into linear motion.

[0156] A pinion 1512 may be positioned adjacent to the rack 1510 at the lower central portion of the latch mechanism 1500. The pinion 1512 may be a gear element configured to mesh with the teeth of the rack 1510. The pinion 1512 may receive rotational input from a motor and may drive the rack 1510 linearly, which in turn may actuate the rotating rods 1502 and the associated cam 1504 and follower 1506 assemblies to pivot the support arms between a retaining position and a release position. The rack 1510 and the pinion 1512 may be positioned beneath the vertical cabinet and may actuate the cam and follower system to pivot the support arms between the retaining position and the release position.

[0157] Referring to FIG. 16, an equipment handling module 1600 may be configured to interface with a liquid handling system. The equipment handling module 1600 may show mechanical components involved in transitioning labware from vertical movement within a vertical cabinet 1602 to horizontal movement along an x-axis carriage 1608 for delivery into an enclosure of a pipette system.

[0158] The vertical cabinet 1602 may be positioned at an upper right portion of the equipment handling module 1600. The vertical cabinet 1602 may be configured to store a stack of labware. The vertical cabinet 1602 may include structural frame members with mounting holes arrangedDocket No. G082-0034PCT1along surfaces of the vertical cabinet 1602 that provide support and define a storage area for stacked labware within the equipment handling module 1600.

[0159] With continued reference to FIG. 16, a z-axis rail 1604 may be positioned within the vertical cabinet 1602. The z-axis rail 1604 may extend vertically along a right side of the equipment handling module 1600. The z-axis rail 1604 may provide a linear guide for vertical movement of components within the vertical cabinet 1602, enabling precise positioning of labware during a transfer process from the stack to a horizontal transport system. The z-axis rail 1604 may support the z-axis carriage 1618 that is shown having a U-shaped configuration that enables the x-axis carriage to receive the labware platform at a space between the prongs of the z-axis carriage 1618 and to remove the labware platform from the z-axis carriage to move horizontally into the liquid handling system.

[0160] A latch 1612 may be positioned at an upper portion of the vertical cabinet 1602. The latch 1612 may be configured to retain the stack of labware within the vertical cabinet 1602 and release individual pieces of labware onto a labware platform 1610 during operation. In some cases, the latch 1612 may include support arms that pivot between a retaining position and a release position to control the release of labware from the stack.

[0161] Two rotating rods 1614 may extend vertically within the vertical cabinet 1602 on opposite sides of the equipment handling module 1600. The rotating rods 1614 may be coupled to the latch 1612 mechanism. The rotating rods 1614 may be configured to actuate a pivoting motion of support arms that retain and release labware from the stack stored within the vertical cabinet 1602. Though only a single latch 1612 is shown in FIG. 16, there may be a latch 1612 on the side opposite the one shown in FIG. 16 and there may be additional latches at the adjacent sides of the labware in some embodiments.

[0162] As further shown in FIG. 16, the labware platform 1610 may be positioned at a left side of the equipment handling module 1600. The labware platform 1610 may extend horizontally. The labware platform 1610 may feature a flat rectangular surface with multiple openings arranged in a grid pattern. The labware platform 1610 may be configured to receive labware from the stack within the vertical cabinet 1602 and support the labware during transport operations into the enclosure of the pipette system.Docket No. 0082-0034PCT1

[0163] A horizontal rail 1606 may extend along a base of the equipment handling module 1600 beneath the labware platform 1610. The horizontal rail 1606 may provide a linear guide for horizontal movement of the x-axis carriage 1608 along an x-axis direction.

[0164] The x-axis carriage 1608 may be positioned on the horizontal rail 1606 adjacent to the labware platform 1610. The x-axis carriage 1608 may be configured to receive the labware platform 1610 from a z-axis carriage and transport the labware platform 1610 horizontally into the enclosure of the liquid handling system. The x-axis carriage 1608 may include mechanical components that enable precise linear motion along a horizontal axis.

[0165] Motors 1616 may be positioned at a lower right portion of the equipment handling module 1600. The motors 1616 may be configured to drive mechanical components of the equipment handling module 1600, providing a driving force for moving components vertically along the z-axis rail 1604 and horizontally along the horizontal rail 1606. A spring element may be visible adjacent to the motors 1616. The spring element may be associated with a positioning system that ensures accurate placement of components against hard stops for repeatable and precise positioning of labware within the liquid handling system.

[0166] In some cases, the equipment handling module 1600 may include a read switch positioned on the x-axis carriage 1608 to detect when the labware platform 1610 is present and properly positioned at a tower position for loading labware from the vertical cabinet 1602. The equipment handling module 1600 may include a read switch positioned at a gripper position inside the robot enclosure to detect when the labware platform 1610 is present and properly positioned for interaction with a robot of the pipette system.

[0167] In some cases, the equipment handling module 1600 may include a photo interrupter positioned on a lead screw mechanism to detect a home position of the x-axis carriage 1608. The equipment handling module 1600 may include a photo interrupter positioned on a z-axis lead screw and lead nut mechanism to detect a home position of a z-axis carriage within the vertical cabinet 1602.

[0168] In some cases, the equipment handling module 1600 may include a door switch that interfaces with a lockout system of the liquid handling system to detect if a door of the equipment handling module 1600 is open and prevent UV or other leakage through the equipment handling module 1600. The equipment handling module 1600 may include spring-loaded electrical contactsDocket No. 0082-0034PCT1that interface with window interlock contacts of the liquid handling system to automatically close an interlock circuit when the equipment handling module 1600 is properly installed.

[0169] In some cases, the equipment handling module 1600 may include a time-of-flight sensor positioned within the vertical cabinet 1602 and directed along a z-axis to measure distance to the labware stack and determine the number of labware remaining based on stack height. The equipment handling module 1600 may include a time-of-flight sensor positioned parallel to the x-axis to validate that labware is properly dispensed and detect equipment jams when labware fails to advance along the x-axis.

[0170] In some cases, the equipment handling module 1600 may include an adapter configured to fit onto the labware platform 1610 to hold labware with non-standard geometries that would not otherwise be compatible with the equipment handling module 1600. The adapter may include geometry to interface with and locate both the labware platform 1610 and other components such as lids or other non-standard labware. In some cases, the adapter may be configured to stack on top of lids to enable stacking of multiple adapters with lids in between.

[0171] A computing device associated with the equipment handling module 1600 may be configured to compare sensor data indicating stack height against expected height based on labware type to detect incorrect labware installation and notify a user. The computing device may be configured to compare a height of the labware stack against a height of equipment required by a specific protocol to determine if sufficient labware is available before running the protocol.

[0172] In some cases, the equipment handling module 1600 may include sensors such as a camera configured to verify that the equipment is of a proper type based on object recognition techniques. The time-of-flight sensor may be configured to validate transfers by a gripper by detecting whether labware is present after the gripper was supposed to transfer the labware.

[0173] FIG. 17 illustrates a portion of an equipment handling module showing an interaction between a z-axis carriage and an x-axis carriage during a vertical to horizontal transfer of a labware platform, according to at least one example. Referring to FIG. 17, an equipment handling module 1700 may be configured to transfer a labware platform between an x-axis carriage 1704 and a z-axis carriage 1706 within an equipment handling system. The equipment handling module 1700 may show mechanical components involved in transitioning labware from vertical movement to horizontal movement for delivery into an enclosure of a pipette system.Docket No. 0082-0034PCT1

[0174] A horizontal rail 1702 may extend along a left side of the equipment handling module 1700. The horizontal rail 1702 may provide a linear guide for horizontal movement of components along an x-axis direction for movement of the x-axis carriage 1704. The horizontal rail 1702 may include structural support elements that enable precise horizontal positioning of the x-axis carriage 1704 during transport operations.

[0175] The x-axis carriage 1704 may be positioned at a transition zone from the z-axis carriage 1706 to the x-axis carriage 1704. The x-axis carriage 1704 may be configured to receive and support labware such as a labware platform during transport operations. The x-axis carriage 1704 may feature a flat rectangular surface with multiple openings and mounting features that enable engagement with the labware platform during transfer operations.

[0176] The z-axis carriage 1706 may be configured to move vertically to interface with the x-axis carriage 1704 along the z-direction. The z-axis carriage 1706 may have a U-shape with a base of the “U” positioned adjacent a positioning system 1708 such that the x-axis carriage 1704 can carry the labware platform away from the z-axis carriage 1706. The z-axis carriage 1706 may include mechanical components that enable precise vertical movement within a vertical cabinet of the equipment handling module 1700.

[0177] A positioning system 1708 may be positioned at a lower right portion of the equipment handling module 1700 adjacent to the z-axis carriage 1706. The positioning system 1708 may include an element that provides movement capability for positioning components within the equipment handling module 1700 such as movement of the x-axis carriage 1704 or z-axis carriage 1706 in response to being driven by a motor.

[0178] With continued reference to FIG. 17, two z-axis locating pins 1710 may be visible, positioned on opposite sides of the x-axis carriage 1704. The z-axis locating pins 1710 may extend vertically from the z-axis carriage 1706 and may be configured to engage with corresponding pockets in the labware platform during vertical movement. The z-axis locating pins 1710 may provide accurate positioning of the labware platform relative to the z-axis carriage 1706 during vertical travel within the vertical cabinet.

[0179] Two magnets 1712 may be positioned on the x-axis carriage 1704. The magnets 1712 may be elongated elements configured to magnetically engage with corresponding magnet attractors on the labware platform to secure the labware platform during horizontal movement. The magnets 1712 may draw the x-axis carriage 1704 toward the labware platform to maintain accurateDocket No. 0082-0034PCT1positioning during transport operations. Additional magnets on the z-axis carriage may also connect to the labware platform (not shown in FIG. 17).

[0180] An x-axis pin pocket 1714 may be positioned on the x-axis carriage 1704. The x-axis pin pocket 1714 may be a recessed area configured to receive a locating pin or a spring-loaded pin to dislodge the labware platform from the z-axis carriage 1706 as it lowers. The x-axis pin pocket 1714 may ensure accurate positioning of the x-axis carriage 1704 relative to the labware platform during the handoff operation between vertical and horizontal movement.

[0181] A labware pin 1716 may be positioned on the x-axis carriage 1704 adjacent to the magnet 1712. The labware pin 1716 may extend upward from the surface of the x-axis carriage 1704 and may be configured to engage with corresponding features on the labware platform to secure the labware and ensure alignment during transport operations into the enclosure of the liquid handling system.

[0182] Unless explicitly excluded, the use of the singular to describe a component, structure, or operation does not exclude the use of plural such components, structures, or operations or their equivalents. As used herein, the word “or” refers to any possible permutation of a set of items. For example, the phrase “A, B, or C” refers to at least one of A, B, C, or any combination thereof, such as any of: A; B; C; A and B; A and C; B and C; A, B, and C; or multiple of any item such as A and A; B, B, and C; A, A, B, C, and C; etc.

[0183] While aspects of the present disclosure have been particularly shown and described with reference to the embodiments above, it will be understood by those skilled in the art that various additional embodiments may be contemplated by the modification of the disclosed machines, systems, and methods without departing from the spirit and scope of what is disclosed. Such embodiments should be understood to fall within the scope of the present disclosure as determined based upon the claims and any equivalents thereof.EXAMPLE CLAUSES

[0184] A. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising: a vertical cabinet configured to store a stack of labware; a labware platform configured to receive labware from the stack of labware and support the labware; a z-axis carriage configured to move vertically within the vertical cabinet and interface with the labware platform to move the labware platform within the vertical cabinet, wherein the z-axis carriage comprises: a first set of locating pins configuredDocket No. 0082-0034PCT1to engage with the labware platform during vertical movement; an x-axis carriage configured to receive the labware platform from the z-axis carriage when the z-axis carriage reaches a bottom position of travel and transport the labware platform horizontally into the enclosure of the pipette system, wherein the x-axis carriage comprises: a second set of locating pins configured to engage with the labware platform during horizontal transport, wherein the second set of locating pins engage as the first set of locating pins disengage from the labware platform.

[0185] B. The equipment handling system of paragraph A, wherein the z-axis carriage comprises a first set of magnets configured to magnetically engage with the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of magnets configured to magnetically engage with the labware platform during horizontal transport.

[0186] C. The equipment handling system of paragraph A or B, further comprising a set of spring-loaded pins disposed adjacent the bottom position of the z-axis carriage, the spring-loaded pins configured to disengage the labware platform from the z-axis carriage as the z-axis carriage lowers to the bottom position.

[0187] D The equipment handling system of paragraph C, wherein the z-axis carriage is configured to compress the spring-loaded pins as the z-axis carriage lowers to the bottom position, wherein compression of the spring-loaded pins causes the spring-loaded pins to disengage from the lab ware platform.

[0188] E. The equipment handling system of any of paragraphs A-D, further comprising a latch mechanism configured to retain the stack of labware within the vertical cabinet, wherein the latch mechanism comprises: a pair of support arms positioned on opposite sides of the vertical cabinet, each support arm configured to pivot between a retaining position and a release position; a cam and follower system coupled to the support arms; and a motor configured to drive the cam and follower system to pivot the support arms from the retaining position to the release position, thereby releasing labware from the stack onto the labware platform when the z-axis carriage is at a top position.

[0189] F. The equipment handling system of paragraph E, wherein each support arm comprises a hook-shaped element configured to engage with a corresponding feature on the labware, and wherein the support arms are configured to pivot on cams to move laterally between the retaining position and the release position.Docket No. 0082-0034PCT1

[0190] G. The equipment handling system of any of paragraphs A-F, further comprising: a first magnetic switch positioned on the x-axis carriage, the first magnetic switch configured to detect presence of the labware platform on the x-axis carriage; and a second magnetic switch positioned at an end of travel of the x-axis carriage within the enclosure of the pipette system, the second magnetic switch configured to indicate when the x-axis carriage has reached the end of travel.

[0191] H. The equipment handling system of any of paragraphs A-G, wherein the z-axis carriage comprises a U-shaped configuration defining an interior space, and wherein the x-axis carriage is configured to fit within the interior space formed by the U-shaped configuration of the z-axis carriage when the z-axis carriage is at the bottom position of travel.

[0192] I. The equipment handling system of any of paragraphs A-H, wherein the bottom position of the z-axis carriage is positioned such that an upper end of the first set of locating pins is below a bottom surface of the labware platform when the labware platform is positioned on the x-axis carriage.

[0193] J. The equipment handling system of any of paragraphs A-I, wherein the equipment handling system is configured to be modularly attached to a liquid handling robot, and wherein multiple equipment handling systems are configured to be attached to the liquid handling robot in a side-by-side arrangement.

[0194] K. The equipment handling system of any of paragraphs A-J, wherein the equipment handling system is configured to attach to the liquid handling robot without occupying deck space within the enclosure of the pipette system, wherein the deck space remains available for other labware and operations.

[0195] L. The equipment handling system of any of paragraphs A-K, wherein the vertical cabinet is configured to receive labware loaded manually by a user through a door positioned on a side of the vertical cabinet.

[0196] M. The equipment handling system of any of paragraphs A-L, wherein the vertical cabinet is configured to receive labware loaded robotically by a robotic element of the pipette system through the port in the enclosure.

[0197] N. The equipment handling system of any of paragraphs A-M, wherein the vertical cabinet is configured to receive labware loaded both manually by a user and robotically by a robotic element of the pipette system.Docket No. 0082-0034PCT1

[0198] O. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising: a labware platform configured to receive and support labware; a z-axis carriage configured to move vertically and interface with the labware platform to move the labware platform vertically, wherein the z-axis carriage comprises a first geometry; an x-axis carriage configured to receive the labware platform from the z-axis carriage and transport the labware platform horizontally into the enclosure of the pipette system, wherein the x-axis carriage comprises a second geometry; wherein the first geometry of the z-axis carriage and the second geometry of the x-axis carriage are configured to enable the z-axis carriage to move past the x-axis carriage and the x-axis carriage to move past the z-axis carriage along their respective directions of travel without interference.

[0199] P. The equipment handling system of paragraph O, wherein the z-axis carriage comprises a first set of locating pins configured to engage with the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of locating pins configured to engage with the labware platform during horizontal transport.

[0200] Q. The equipment handling system of paragraph P, wherein the second set of locating pins engage with the labware platform as the first set of locating pins disengage from the labware platform when the z-axis carriage reaches a bottom position of travel.

[0201] R. The equipment handling system of any of paragraphs O-Q, wherein the z-axis carriage comprises a first set of magnets configured to magnetically engage with corresponding magnets of the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of magnets configured to magnetically engage with corresponding magnets of the labware platform during horizontal transport.

[0202] S. The equipment handling system of paragraph R, further comprising a set of spring-loaded pins disposed adjacent a bottom position of the z-axis carriage, the spring-loaded pins configured to disengage the labware platform from the z-axis carriage as the z-axis carriage lowers to the bottom position.

[0203] T. The equipment handling system of paragraph S, wherein the z-axis carriage is configured to compress the spring-loaded pins as the z-axis carriage lowers to the bottom position, wherein compression of the spring-loaded pins causes the labware platform to disengage from the z-axis carriage.Docket No. 0082-0034PCT1

[0204] U. The equipment handling system of any of paragraphs O-T, wherein the first geometry of the z-axis carriage defines an open middle space, and wherein the second geometry of the x-axis carriage is configured to reside within the open middle space of the z-axis carriage when the z-axis carriage is at a bottom position of travel.

[0205] V. The equipment handling system of any of paragraphs O-U, wherein the second geometry of the x-axis carriage defines an open middle space, and wherein the first geometry of the z-axis carriage is configured to reside within the open middle space of the x-axis carriage when the z-axis carriage is at a bottom position of travel.

[0206] W. A method for providing equipment through a port in an enclosure of a pipette system, the method comprising: storing a stack of labware in a vertical cabinet; positioning a labware platform to receive labware from the stack of labware; engaging the labware platform with a z-axis carriage using a first set of locating pins; moving the z-axis carriage vertically within the vertical cabinet to lower the labware platform to a bottom position of travel; disengaging the first set of locating pins from the labware platform as the z-axis carriage reaches the bottom position of travel; engaging the labware platform with an x-axis carriage using a second set of locating pins; and transporting the labware platform horizontally into the enclosure of the pipette system using the x-axis carriage.

[0207] X. The method of paragraph W, further comprising: detecting presence of the labware platform on the x-axis carriage using a first magnetic switch positioned on the x-axis carriage; and determining when the x-axis carriage has reached an end of travel within the enclosure of the pipette system using a second magnetic switch positioned at the end of travel.

[0208] Y. The method of paragraph W or X, further comprising: retaining the stack of labware within the vertical cabinet using a latch mechanism comprising a pair of support arms positioned on opposite sides of the vertical cabinet; and pivoting the support arms from a retaining position to a release position using a cam and follower system driven by a motor to release labware from the stack onto the lab ware platform.

[0209] Z. An equipment handling system comprising: a cabinet configured to store labware; a modular interface configured to attach the equipment handling system to a liquid handling robot; and a transport mechanism configured to move labware from the cabinet into a work area of the liquid handling robot, wherein the liquid handling robot is configured to receive the labware from the transport mechanism.Docket No. D082-0034PCT1

[0210] AA. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising: a vertical cabinet configured to store a stack of labware; a labware platform configured to receive labware from the stack of labware and support the labware; a z-axis carriage configured to move vertically within the vertical cabinet and interface with the labware platform to move the labware platform within the vertical cabinet; an x-axis carriage configured to receive the labware platform from the z-axis carriage when the z-axis carriage reaches a bottom position of travel and transport the labware platform horizontally into the enclosure of the pipette system.

[0211] AB. The equipment handling system of paragraph AA, wherein the z-axis carriage comprises a first set of locating pins configured to engage with the labware platform during vertical movement.

[0212] AC. The equipment handling system of paragraph AB, wherein the x-axis carriage comprises a second set of locating pins configured to engage with the labware platform during horizontal transport.

[0213] AD. The equipment handling system of paragraph AC, wherein the second set of locating pins engage as the first set of locating pins disengage from the labware platform.

Claims

Docket No. 0082-0034PCT1CLAIMS1. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising:a vertical cabinet configured to store a stack of labware;a labware platform configured to receive labware from the stack of labware and support the labware;a z-axis carriage configured to move vertically within the vertical cabinet and interface with the labware platform to move the labware platform within the vertical cabinet, wherein the z-axis carriage comprises:a first set of locating pins configured to engage with the labware platform during vertical movement;an x-axis carriage configured to receive the labware platform from the z-axis carriage when the z-axis carriage reaches a bottom position of travel and transport the labware platform horizontally into the enclosure of the pipette system, wherein the x-axis carriage comprises:a second set of locating pins configured to engage with the labware platform during horizontal transport, wherein the second set of locating pins engage as the first set of locating pins disengage from the labware platform.

2. The equipment handling system of claim 1, wherein the z-axis carriage comprises a first set of magnets configured to magnetically engage with the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of magnets configured to magnetically engage with the labware platform during horizontal transport.

3. The equipment handling system of claim 1, further comprising a set of spring-loaded pins disposed adjacent the bottom position of the z-axis carriage, the spring-loaded pins configured to disengage the labware platform from the z-axis carriage as the z-axis carriage lowers to the bottom position.

4. The equipment handling system of claim 3, wherein the z-axis carriage is configured to compress the spring-loaded pins as the z-axis carriage lowers to the bottom position, whereinDocket No. 0082-0034PCT1compression of the spring-loaded pins causes the spring-loaded pins to disengage from the labware platform.

5. The equipment handling system of claim 1, further comprising a latch mechanism configured to retain the stack of labware within the vertical cabinet, wherein the latch mechanism comprises:a pair of support arms positioned on opposite sides of the vertical cabinet, each support arm configured to pivot between a retaining position and a release position;a cam and follower system coupled to the support arms; anda motor configured to drive the cam and follower system to pivot the support arms from the retaining position to the release position, thereby releasing labware from the stack onto the labware platform when the z-axis carriage is at a top position.

6. The equipment handling system of claim 5, wherein each support arm comprises a hook-shaped element configured to engage with a corresponding feature on the labware, and wherein the support arms are configured to pivot on cams to move laterally between the retaining position and the release position.

7. The equipment handling system of claim 1, further comprising:a first magnetic switch positioned on the x-axis carriage, the first magnetic switch configured to detect presence of the labware platform on the x-axis carriage; anda second magnetic switch positioned at an end of travel of the x-axis carriage within the enclosure of the pipette system, the second magnetic switch configured to indicate when the x-axis carriage has reached the end of travel.

8. The equipment handling system of claim 1, wherein the z-axis carriage comprises a U-shaped configuration defining an interior space, and wherein the x-axis carriage is configured to fit within the interior space formed by the U-shaped configuration of the z-axis carriage when the z-axis carriage is at the bottom position of travel.Docket No. 0082-0034PCT19. The equipment handling system of claim 1, wherein the bottom position of the z-axis carriage is positioned such that an upper end of the first set of locating pins is below a bottom surface of the labware platform when the labware platform is positioned on the x-axis carriage.

10. The equipment handling system of claim 1, wherein the equipment handling system is configured to be modularly attached to a liquid handling robot, and wherein multiple equipment handling systems are configured to be attached to the liquid handling robot in a side-by-side arrangement.

11. The equipment handling system of claim 1, wherein the equipment handling system is configured to attach to the liquid handling robot without occupying deck space within the enclosure of the pipette system, wherein the deck space remains available for other labware and operations.

12. The equipment handling system of claim 1, wherein the vertical cabinet is configured to receive labware loaded manually by a user through a door positioned on a side of the vertical cabinet.

13. The equipment handling system of claim 1, wherein the vertical cabinet is configured to receive labware loaded robotically by a robotic element of the pipette system through the port in the enclosure.

14. The equipment handling system of claim 1, wherein the vertical cabinet is configured to receive labware loaded both manually by a user and robotically by a robotic element of the pipette system.

15. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising:a labware platform configured to receive and support labware;a z-axis carriage configured to move vertically and interface with the labware platform to move the labware platform vertically, wherein the z-axis carriage comprises a first geometry;Docket No. 0082-0034PCT1an x-axis carriage configured to receive the labware platform from the z-axis carriage and transport the labware platform horizontally into the enclosure of the pipette system, wherein the x-axis carriage comprises a second geometry;wherein the first geometry of the z-axis carriage and the second geometry of the x-axis carriage are configured to enable the z-axis carriage to move past the x-axis carriage and the x-axis carriage to move past the z-axis carriage along their respective directions of travel without interference.

16. The equipment handling system of claim 15, wherein the z-axis carriage comprises a first set of locating pins configured to engage with the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of locating pins configured to engage with the labware platform during horizontal transport.

17. The equipment handling system of claim 16, wherein the second set of locating pins engage with the labware platform as the first set of locating pins disengage from the labware platform when the z-axis carriage reaches a bottom position of travel.

18. The equipment handling system of claim 15, wherein the z-axis carriage comprises a first set of magnets configured to magnetically engage with corresponding magnets of the labware platform during vertical movement, and wherein the x-axis carriage comprises a second set of magnets configured to magnetically engage with corresponding magnets of the labware platform during horizontal transport.

19. The equipment handling system of claim 18, further comprising a set of spring-loaded pins disposed adjacent a bottom position of the z-axis carriage, the spring-loaded pins configured to disengage the labware platform from the z-axis carriage as the z-axis carriage lowers to the bottom position.

20. The equipment handling system of claim 19, wherein the z-axis carriage is configured to compress the spring-loaded pins as the z-axis carriage lowers to the bottom position, whereinDocket No. 0082-0034PCT1compression of the spring-loaded pins causes the labware platform to disengage from the z-axis carriage.

21. The equipment handling system of claim 15, wherein the first geometry of the z-axis carriage defines an open middle space, and wherein the second geometry of the x-axis carriage is configured to reside within the open middle space of the z-axis carriage when the z-axis carriage is at a bottom position of travel.

22. The equipment handling system of claim 15, wherein the second geometry of the x-axis carriage defines an open middle space, and wherein the first geometry of the z-axis carriage is configured to reside within the open middle space of the x-axis carriage when the z-axis carriage is at a bottom position of travel.

23. A method for providing equipment through a port in an enclosure of a pipette system, the method comprising:storing a stack of labware in a vertical cabinet;positioning a labware platform to receive labware from the stack of labware; engaging the labware platform with a z-axis carriage using a first set of locating pins; moving the z-axis carriage vertically within the vertical cabinet to lower the labware platform to a bottom position of travel;disengaging the first set of locating pins from the labware platform as the z-axis carriage reaches the bottom position of travel;engaging the labware platform with an x-axis carriage using a second set of locating pins; andtransporting the labware platform horizontally into the enclosure of the pipette system using the x-axis carriage.

24. The method of claim 23, further comprising:detecting presence of the labware platform on the x-axis carriage using a first magnetic switch positioned on the x-axis carriage; andDocket No. 0082-0034PCT1determining when the x-axis carriage has reached an end of travel within the enclosure of the pipette system using a second magnetic switch positioned at the end of travel.

25. The method of claim 23, further comprising:retaining the stack of labware within the vertical cabinet using a latch mechanism comprising a pair of support arms positioned on opposite sides of the vertical cabinet; and pivoting the support arms from a retaining position to a release position using a cam and follower system driven by a motor to release labware from the stack onto the labware platform.

26. An equipment handling system comprising:a cabinet configured to store labware;a modular interface configured to attach the equipment handling system to a liquid handling robot; anda transport mechanism configured to move labware from the cabinet into a work area of the liquid handling robot, wherein the liquid handling robot is configured to receive the labware from the transport mechanism.

27. An equipment handling system for providing equipment through a port in an enclosure of a pipette system, the equipment handling system comprising:a vertical cabinet configured to store a stack of labware;a labware platform configured to receive labware from the stack of labware and support the labware;a z-axis carriage configured to move vertically within the vertical cabinet and interface with the labware platform to move the labware platform within the vertical cabinet;an x-axis carriage configured to receive the labware platform from the z-axis carriage when the z-axis carriage reaches a bottom position of travel and transport the labware platform horizontally into the enclosure of the pipette system.

28. The equipment handling system of claim 27, wherein the z-axis carriage comprises a first set of locating pins configured to engage with the lab ware platform during vertical movement.Docket No. 0082-0034PCT129. The equipment handling system of claim 28, wherein the x-axis carriage comprises a second set of locating pins configured to engage with the lab ware platform during horizontal transport.

30. The equipment handling system of claim 29, wherein the second set of locating pins engage as the first set of locating pins disengage from the labware platform.

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