Adhesive sheet
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- HISAMITSU PHARM CO INC
- Filing Date
- 2026-01-28
- Publication Date
- 2026-08-06
Smart Images
Figure JP2026002828_06082026_PF_FP_ABST
Abstract
Description
Adhesive sheet
[0001] One aspect of this disclosure relates to adhesive sheets.
[0002] Patent Document 1 describes a roll-type external adhesive patch comprising a core, an external adhesive patch wound in a roll shape around the outer circumference of the core, and a pair of side covers attached to both ends of the core, covering both end faces of the external adhesive patch from both sides. In this roll-type external adhesive patch, a perforated line is formed on the external adhesive patch. This allows the patch to be cut according to the size of the area to which it is to be applied. Patent Document 2 describes a sheet-type adhesive patch comprising a support and a perforated release film. Patent Document 3 describes an adhesive sheet for skin application comprising a substrate having voids provided at regular intervals and an adhesive layer provided on at least one side of the substrate.
[0003] Japanese Patent Publication No. 2001-114672, Japanese Patent Publication No. 2003-284739, Japanese Patent Publication No. 2005-304877
[0004] The adhesive sheets described above may be cut along the perforations according to the size of the area to be applied, or they may be applied to relatively large areas with the perforations remaining. In the former case, excellent tearability by hand is desirable. In the latter case, it is desirable that the adhesive sheet does not easily get cut along the perforations while it is applied. Therefore, an adhesive sheet that has excellent tearability by hand and prevents unintended cutting is desired.
[0005] An adhesive sheet according to one aspect of this disclosure comprises a support, an adhesive layer provided on the support, a release liner provided on the adhesive layer so as to sandwich the adhesive layer together with the support, and perforations having a plurality of cuts that penetrate the support, the adhesive layer, and the release liner, respectively. The support is formed of rayon pulp, which is a mixture of rayon and pulp, and the elongation at the breaking point of the support in the state where the plurality of cuts are not formed is 33% GL or less.
[0006] In this respect, by having a fracture elongation of 33%GL or less for a support made of rayon pulp, it is possible to improve tearability while suppressing unintended breakage.
[0007] According to one aspect of this disclosure, it is possible to provide an adhesive sheet that has excellent tearability and suppresses unintended cutting.
[0008] This is a perspective view of the adhesive sheet. This is a plan view of the adhesive sheet seen from above. This is a diagram showing a test specimen used to measure the breaking strength. This is a plan view of an adhesive sheet seen from above, relating to a modified example.
[0009] The following describes various examples in this disclosure in detail with reference to the attached drawings. In the description of the drawings, identical or equivalent elements are denoted by the same reference numeral, and redundant descriptions are omitted.
[0010] [Structure of the Adhesive Sheet] Figure 1 is a perspective view of the adhesive sheet 10. Figure 2 is a plan view of the adhesive sheet 10 seen from above. In Figure 2, the area enclosed by the dashed line is shown in enlargement. The adhesive sheet 10 may contain a drug, in which case it is a preparation used as a poultice or tape. The adhesive sheet 10 is formed in a rectangular shape having a longitudinal direction X and a transverse direction Y. The longitudinal direction X and the transverse direction Y are orthogonal to each other. The long side of the adhesive sheet 10 is, for example, 140 mm, and the short side of the adhesive sheet 10 is, for example, 100 mm. The adhesive sheet 10 comprises a support 12, an adhesive layer 14 provided on the support 12, and a release liner 16 provided on the adhesive layer 14 so as to sandwich the adhesive layer 14 together with the support 12. The adhesive layer 14 is formed on substantially the entire main surface of the support 12. The release liner 16 is peelably attached to the working surface of the adhesive layer 14. The working surface of the adhesive layer 14 is the surface that comes into contact with the user's skin when the adhesive sheet 10 is used.
[0011] The support 12 is a sheet-like member. The support 12 may be stretchable. The material of the support 12 is a nonwoven fabric. The nonwoven fabric is formed from a mixture of rayon and pulp (rayon pulp). The lower limit of the density of the support 12 is 0.05 g / cm³. ３ The above is also acceptable, 0.12 g / cm³３ The above may also be applicable, 0.14 g / cm ３ or more. On the other hand, the upper limit value of the density of the support 12 may be 0.50 g / cm ３ or less, may be 0.30 g / cm ３ or less, may be 0.20 g / cm ３ or less. The density of the support 12 may be 0.05 to 0.50 g / cm ３ or may be 0.12 to 0.30 g / cm ３ or may be 0.14 to 0.20 g / cm ３ or may be. By setting the density within such a range, it tends to suppress the unintended cutting of the adhesive sheet 10 and improve the tearability of the adhesive sheet 10.
[0012] In the support 12, the greater the weight ratio of rayon to pulp, the more the strength of the support tends to improve, and there is a tendency to suppress the unintended cutting of the adhesive sheet 10. On the other hand, the greater the weight ratio of rayon, the more the strength of the support tends to decrease, and there is a tendency to improve the tearability of the adhesive sheet 10.
[0013] The support 12 may be any that can support the adhesive layer 14. Examples of the support 12 include woven fabrics (including knitted fabrics), non-woven fabrics, resin films, foamed sheets, and paper. When using a woven fabric, non-woven fabric, or resin film as the support 12, the material may be, for example, polyolefins such as polyethylene, polypropylene, and polybutylene, polyesters such as polyethylene terephthalate, rayon, rayon pulp, polyurethane, and cotton. These may be used alone, in combination of two or more, and may be single-layer or laminated.
[0014] When spreading an adhesive composition containing water on the non-woven fabric support 12, there is a risk that the adhesive composition may bleed to the back side of the support 12 through the mesh of the support 12. Considering this point, the basis weight of the support 12 may be 20 to 100 g / m ２ or may be 30 to 90 g / m ２However, this is acceptable. By setting the basis weight within this range, the adhesive composition tends to spread without seeping through the gaps in the support 12 to the back side of the support 12. In addition, the anchoring properties between the support 12 and the adhesive layer 14 can be maintained.
[0015] The thickness of the support 12 may be set to, for example, a range of 0.005 to 1 mm. Setting the thickness to 0.005 mm or more is to facilitate handling of the adhesive sheet 10. Setting the thickness to 1 mm or less is to prevent the hardness of the support 12 from affecting the adhesion of the adhesive sheet 10.
[0016] The adhesive layer 14 is a layer that has adhesive properties that allow it to adhere to human skin. If the adhesive sheet 10 is a poultice, the adhesive layer 14 contains a drug, a water-soluble polymer, and water. If the adhesive sheet 10 is a tape, the adhesive layer 14 is composed of a drug and a non-aqueous material.
[0017] If the adhesive sheet 10 is a poultice, the adhesive layer 14 contains a drug, water, a polyacrylic acid neutralized product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion.
[0018] The drugs are not particularly limited as long as they are absorbed through the skin. Examples of drugs include nonsteroidal anti-inflammatory drugs or their esters such as indomethacin, felbinac, flurbiprofen, diclofenac, diclofenac sodium, methyl salicylate, glycol salicylate, and ketoprofen; antihistamines such as diphenhydramine; analgesics such as aspirin, acetaminophen, ibuprofen, and loxoprofen sodium; local anesthetics such as lidocaine; muscle relaxants such as succinylcholine chloride; antifungal agents such as clotrimazole; antihypertensive agents such as clonidine; vasodilators such as nitroglycerin and isosorbide dinitrate; vitamins such as vitamin A, vitamin E (tocopherol), tocopherol acetate, vitamin K, octotiamine, and riboflavin butyrate; prostaglandins; scopolamine, fentanyl, capsicum extract, l-menthol, dl-camphor, and nonyl vanillylamide. Some drugs have two optical isomers, R- and S-isomers. The drug used in this embodiment may be either one optical isomer or a mixture of the two optical isomers in any proportion. The drug may also be in the form of a pharmaceutically acceptable salt. Examples of pharmaceutically acceptable salts include inorganic base salts such as sodium salts, potassium salts, and calcium salts; organic base salts such as amine salts such as monoethanolamine and diethanolamine; inorganic acid salts such as hydrochloride, nitrate, and phosphate; and organic acid salts such as acetate, lactate, benzenesulfonate, and citrate.
[0019] The amount of drug in the adhesive layer 14 should be such that the drug exerts its therapeutic effect, and this amount varies depending on the type of drug. For example, based on the total mass of the adhesive layer, the amount of glycol salicylate can be 1% to 3% by mass, and the amount of l-menthol can be 0.5% to 1.5% by mass.
[0020] The water content in the adhesive layer 14 can be 30% to 70% by mass, based on the total mass of the adhesive layer 14, and may be 40% to 60% by mass, or 45% to 55% by mass.
[0021] The polyacrylic acid neutralized product may be a fully neutralized polyacrylic acid, a partially neutralized polyacrylic acid, or a mixture thereof. Examples of polyacrylic acid neutralized products include polyacrylate salts, such as sodium salts, potassium salts, calcium salts, and ammonium salts. A partially neutralized polyacrylic acid product is one in which structural units derived from acrylic acid and structural units derived from acrylate salts are present in any proportion in a single polymer chain. It is preferable to use a partially neutralized polyacrylic acid product in which 50 mol% of the carboxyl groups in a single polymer chain are neutralized, or 35 mol% are neutralized, or both. The content of the polyacrylic acid neutralized product in the adhesive layer 14 can be 2% to 15% by mass, 3% to 10% by mass, or 3% to 5% by mass, based on the total mass of the adhesive layer 14.
[0022] The methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is an emulsion (aqueous emulsion) in which the methyl acrylate / 2-ethylhexyl acrylate copolymer resin is dispersed in water. The content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin in the emulsion can be 55% to 65% by mass based on the total mass of the emulsion. The emulsion may also contain an emulsifier, such as polyoxyethylene nonylphenyl ether. The content of the emulsifier can be 1% to 5% by mass based on the total mass of the emulsion. The content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion in the adhesive layer 14 is 1.5% to 15% by mass (corresponding to 0.825% to 9.75% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin) based on the total mass of the adhesive layer 14, preferably 2% to 14% by mass (corresponding to 1.1% to 9.1% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin), and more preferably 3% to 13% by mass (corresponding to 1.65% to 8.45% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin). Examples of commercially available methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsions include Nikazol TS-620 (trade name, manufactured by Nippon Carbide Industries, Ltd.) and BPW HW-2 (trade name, manufactured by Toyo Chem Co., Ltd.).
[0023] The adhesive layer 14 may also contain other components such as water-soluble polymers (excluding polyacrylic acid neutralized product; the same applies hereinafter), cooling agents, solubilizers, crosslinking agents, fillers, humectants, stabilizers, preservatives, chelating agents, colorants, fragrances, pH adjusters, etc.
[0024] The water-soluble polymer is not particularly limited as long as it can retain moisture in the adhesive layer 14, and those generally known to those skilled in the art can be used. Examples of water-soluble polymers include gelatin, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, hydroxypropyl cellulose, sodium carboxymethylcellulose (carmellose sodium), methylcellulose, and carrageenan. The polyvinyl alcohol may be fully saponified, intermediately saponified, partially saponified, or low-saponified, with intermediate or partially saponified being preferred, and partially saponified being more preferred. The water-soluble polymer may be used alone or in combination of two or more. It is preferable to include at least one selected from the group consisting of gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol as the water-soluble polymer, and it is more preferable to include gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol. If the adhesive layer 14 contains a water-soluble polymer, its content can be 5% to 15% by mass, or 7% to 12% by mass or 8% to 10% by mass, based on the total mass of the adhesive layer 14.
[0025] In the case of a poultice, the adhesive layer 14 contains a drug, water, glycerin, D-sorbitol, polyacrylic acid neutralized and methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, gelatin, polyacrylic acid, partially saponified polyvinyl alcohol, sodium edetate, magnesium aluminometasilicate, and l-menthol. Based on the total mass of the adhesive layer 14, the drug is 0.3% to 2% by mass, water is 40% to 55% by mass, glycerin is 18% to 22% by mass, and D-sorbitol is 3% to 7% by mass. Preferably, the amounts are as follows: neutralized polyacrylic acid is 3% to 5% by mass, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 3% to 13% by mass, gelatin is 1% to 5% by mass, polyacrylic acid is 1% to 5% by mass, partially saponified polyvinyl alcohol is 1% to 5% by mass, sodium edetate is 0.2% to 0.6% by mass, magnesium aluminometasilicate is 0.2% to 0.5% by mass, and l-menthol is 0.5% to 1.5% by mass.
[0026] Examples of cooling agents include l-menthol, thymol, l-isopulegol, and peppermint oil. Cooling agents may be used individually or in combination of two or more. If the adhesive layer 14 contains a cooling agent, its content can be 0.5% to 1.5% by mass, based on the total mass of the adhesive layer 14.
[0027] The solubilizer is not particularly limited as long as it can dissolve the drug, and examples include crotamiton; N-methylpyrrolidone; polyalkylene glycols such as polyethylene glycol (PEG) and polybutylene glycol; oxyalkylene fatty acid esters such as polyethylene glycol monostearate; polyoxyalkylene sorbitan fatty acid esters such as polysorbate 80; sorbitan fatty acid esters such as sorbitan monooleate; and surfactants such as polyoxyethylene hydrogenated castor oil. These solubilizers may be used individually or in combination of two or more. If the adhesive layer 14 contains a solubilizer, its content may be 0.1% to 5% by mass, 0.5% to 3% by mass, or 1% to 3% by mass, based on the total mass of the adhesive layer 14.
[0028] The crosslinking agent is a component used to adjust the progress of the crosslinking reaction between polyacrylic acid neutralized products and the crosslinking reaction between the polyacrylic acid neutralized product and optionally added polyacrylic acid. Crosslinking agents commonly used in poultices can be used. Examples of crosslinking agents include aluminum compounds (magnesium aluminometasilicate, potassium aluminum sulfate (alum), etc.). If the adhesive layer 14 contains a crosslinking agent, its content can be 0.05% to 1% by mass, based on the total mass of the adhesive layer 14, and may be 0.1% to 0.7% by mass or 0.2% to 0.5% by mass.
[0029] Examples of fillers include inorganic fillers such as anhydrous silicic acid, titanium dioxide, synthetic aluminum silicate, kaolin, talc, bentonite, and magnesium aluminometasilicate, and may be one of these or a combination of two or more. If the adhesive layer 14 contains a filler, its content may be 0.1% to 1.5% by mass, based on the total mass of the adhesive layer 14, and may be 0.2% to 1% by mass or 0.3% to 0.7% by mass.
[0030] The humectant is not particularly limited as long as it can suppress the evaporation of moisture from the adhesive layer 14 over time. Examples of humectants include polyhydric alcohols such as glycerin, sorbitol, ethylene glycol, 1,4-butanediol, and polyethylene glycol. These humectants may be used individually or in combination of two or more. It is preferable that the humectant contains at least one selected from the group consisting of glycerin and sorbitol, and more preferably contains both glycerin and sorbitol. When the adhesive layer 14 contains a humectant, its content can be 15% to 45% by mass, 20% to 40% by mass, or 20% to 30% by mass, based on the total mass of the adhesive layer 14.
[0031] Examples of stabilizers include oxybenzone, dibutylhydroxytoluene (BHT), sodium edetate, and UV absorbers (e.g., dibenzoylmethane derivatives). If the adhesive layer 14 contains a stabilizer, its content can be 0.05% to 1% by mass, or 0.1% to 0.6% by mass or 0.2% to 0.6% by mass, based on the total mass of the adhesive layer 14.
[0032] Examples of preservatives include methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, 1,2-pentanediol, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, 4-isopropyl-3-methylphenol, 2-isopropyl-5-methylphenol, phenol, hinokitiol, cresol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, chlorobutanol, benzalkonium chloride, and benzethonium chloride. These preservatives may be used individually or in combination of two or more. If the adhesive layer 14 contains a preservative, its content may be 0.01% to 1% by mass, or 0.05% to 0.5% by mass or 0.1% to 0.2% by mass, based on the total mass of the adhesive layer 14.
[0033] Examples of chelating agents include EDTA (also known as ethylenediaminetetraacetic acid) or its salts, ascorbic acid, pyrophosphate, hexametaphosphate, gluconate, etc. These chelating agents may be used individually or in combination of two or more. More specifically, sodium edetate is an example of an EDTA salt. If the adhesive layer 14 contains a chelating agent, its content may be 0.05% to 1% by mass, 0.1% to 0.6% by mass, or 0.2% to 0.6% by mass, based on the total mass of the adhesive layer 14.
[0034] If the adhesive sheet 10 is a tape, the adhesive layer 14 contains a drug and an adhesive base. Examples of adhesive bases include rubber-based adhesive bases, acrylic-based adhesive bases, and silicone-based adhesive bases. Preferably, the adhesive base is one or more selected from the group consisting of rubber-based adhesive bases, acrylic-based adhesive bases, and silicone-based adhesive bases. The adhesive base may be any of the rubber-based adhesive base, acrylic-based adhesive base, and silicone-based adhesive base, or a combination thereof.
[0035] Examples of rubber-based adhesive bases include styrene-butadiene block copolymer, styrene-butadiene-styrene block copolymer, styrene-isoprene block copolymer, styrene-isoprene-styrene block copolymer, styrene-isobutylene block copolymer, styrene-isobutylene-styrene block copolymer, polyisobutylene, natural rubber, alkyl vinyl ether (co)polymer, polyisoprene, polybutadiene, etc. One of these may be used alone, or two or more may be used in combination.
[0036] From the viewpoint of enabling the adhesive layer 14 to exhibit more sufficient adhesive strength, the rubber-based adhesive base is preferably at least one selected from the group consisting of styrene-isoprene-styrene block copolymer and polyisobutylene.
[0037] Specific examples of styrene-isoprene-styrene block copolymers include Quintac (registered trademark) 3570C (trade name, manufactured by Nippon Zeon Co., Ltd.), SIS5002, SIS5229, SIS5505, SIS5505P (trade names, manufactured by JSR Corporation), SIS5002, SIS5229, SIS5505P, SIS5403P (trade names, manufactured by ENEOS Materials Co., Ltd.), etc. Also, polyisobutylene includes so-called butyl rubber (isobutylene-isoprene rubber). Specific examples include Oppanol (registered trademark) N50, N80, N100, N150, B11, B12, B50, B80, B100, B120, B150, B220 (trade names, manufactured by BASF), RIIR065, 268, 365 (trade names, manufactured by ENEOS Materials Co., Ltd.), JSR (registered trademark) Butyl065, 268, 365 (trade names, manufactured by JSR Corporation), X_Butyl (registered trademark) RB100, 101-3, 301, 402 (trade names, manufactured by ARLANXEO), Exxon (registered trademark) Butyl065, 065S, 068, 068S, 268, 268S, 365, 365S (trade names, manufactured by ExxonMobil), Butyl065, 268, 365 (trade names, manufactured by Nippon Butyl Co., Ltd.), etc.
[0038] The acrylic adhesive base is, for example, a (co)polymer of one or more (meth)acrylic acid alkyl esters. Examples of (meth)acrylic acid alkyl esters include butyl (meth)acrylate, isobutyl (meth)acrylate, hexyl (meth)acrylate, octyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, decyl (meth)acrylate, etc. In this specification, the term "(meth)acrylic acid" means either acrylic acid or methacrylic acid or both, and similar expressions are defined in the same way.
[0039] The acrylic adhesive base may be a copolymer formed from an alkyl (meth)acrylate (main monomer) and a comonomer. Examples of the main monomer include methyl (meth)acrylate, ethyl (meth)acrylate, butyl (meth)acrylate, hexyl (meth)acrylate, heptyl (meth)acrylate, octyl (meth)acrylate, and 2-ethylhexyl (meth)acrylate, and one of these may be used alone or in combination of two or more. The comonomer may be any component that can copolymerize with the alkyl (meth)acrylate. Examples of comonomers include hydroxyalkyl (meth)acrylate, ethylene, propylene, styrene, vinyl acetate, N-vinylpyrrolidone, (meth)acrylic acid, and (meth)acrylamide. The comonomer may be used alone or in combination of two or more.
[0040] Specific examples of the acrylic adhesive base include acrylic acid / octyl acrylate copolymer, 2-ethylhexyl acrylate / vinylpyrrolidone copolymer solution, acrylic ester / vinyl acetate copolymer, 2-ethylhexyl acrylate / 2-ethylhexyl methacrylate / dodecyl methacrylate copolymer, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, acrylic polymers contained in an acrylic resin alkanolamine solution, and the like. Specific examples of such acrylic adhesive bases include Duro-Tak (registered trademark) series such as Duro-Tak (registered trademark) 387-2510, Duro-Tak (registered trademark) 87-2510, Duro-Tak (registered trademark) 387-2287, Duro-Tak (registered trademark) 87-2287, Duro-Tak (registered trademark) 87-4287, Duro-Tak (registered trademark) 387-2516, Duro-Tak (registered trademark) 87-2516, Duro-Tak (registered trademark) 87-2074, Duro-Tak (registered trademark) 87-900A, Duro-Tak (registered trademark) 87-901A, Duro-Tak (registered trademark) 87-9301, Duro-Tak (registered trademark) 87-4098 (manufactured by Henkel); GELVA (registered trademark) series such as GELVA (registered trademark) GMS 788, GELVA (registered trademark) GMS 3083, GELVA (registered trademark) GMS 3253 (manufactured by Henkel); MAS series such as MAS811 (trade name), MAS683 (trade name) (manufactured by Cosmed Pharmaceutical Co., Ltd.); Eudragit (registered trademark) series (manufactured by Evonik), Nikazol (registered trademark) series (manufactured by Nippon Carbide Industries Co., Ltd.), and Ultrazol (registered trademark) series (manufactured by Aika Industries Co., Ltd.).
[0041] Silicone-based adhesives are compounds having an organopolysiloxane skeleton. Examples of silicone-based adhesives include dimethylpolysiloxane, polymethylvinylsiloxane, and polymethylphenylsiloxane. Specific silicone-based adhesive bases include, for example, the MD series (manufactured by DuPont-Toray Specialty Materials Co., Ltd.), such as MD7-4502 Silicone Adhesive and MD7-4602 Silicone Adhesive; BIO-PSA® 7-4301 Silicone Adhesive, BIO-PSA® 7-4302 Silicone Adhesive, BIO-PSA® 7-4201 Silicone Adhesive, BIO-PSA® 7-4202 Silicone Adhesive, BIO-PSA® 7-4101 Silicone Adhesive, BIO-PSA® 7-4102 Silicone Adhesive, BIO-PSA (registered trademark) 7-4601 Silicone Adhesive, BIO-PSA (registered trademark) 7-4602 Silicone Adhesive, BIO-PSA (registered trademark) 7-4501 Silicone Adhesive, BIO-PSA (registered trademark) 7-4502 Silicone Adhesive, BIO-PSA (registered trademark) 7-4401 Silicone Adhesive, BIO-PSA (registered trademark) 7-4402 Silicone Adhesive and other BIO-PSA series (manufactured by DuPont-Toray Specialty Materials Co., Ltd.), Dow Corning (registered trademark) Examples include 7-9800A, Dow Corning (registered trademark), 7-9800B, Dow Corning (registered trademark), and 7-9700A, Dow Corning (registered trademark).
[0042] If the adhesive sheet 10 is a tape, the adhesive layer 14 may optionally contain other additives. Examples of other additives include tackifying resins, plasticizers, absorption enhancers, solvents, fillers, and fragrances.
[0043] The tackifying resin is a component that adjusts the tackiness of the adhesive layer 14. Examples of tackifying resins include petroleum resins, terpene resins, rosin resins, phenolic resins, and xylene resins. Examples of petroleum resins include alicyclic petroleum resins (alicyclic saturated hydrocarbon resins, etc.), aliphatic petroleum resins (aliphatic hydrocarbon resins, etc.), aromatic petroleum resins, etc. More specifically, examples include Alcon P-70, Alcon P-85, Alcon P-90, Alcon P-100, Alcon P-115, Alcon P-125, Alcon M-70, Alcon M-85, Alcon M-90, Alcon M-100, Alcon M-115, Alcon M-125 (all trade names, manufactured by Arakawa Chemical Industries, Ltd.), Escolets 8000 (trade name, manufactured by Esso Petrochemical Co., Ltd.). Examples of terpene resins include pinene polymers (α-pinene polymer, β-pinene polymer, etc.), terpene polymers, dipentene polymers, terpene-phenol polymers, aromatically modified terpene polymers, and pinene-phenol copolymers. More specifically, examples include YS resins (YS resin PXN (1150N, 300N), YS resin PX1000, YS resin TO125, YS resin TO105, etc.), Clearon P105, Clearon M115, Clearon K100 (all trade names, manufactured by Yasuhara Chemical Co., Ltd.), and Tamanol 901 (trade name, manufactured by Arakawa Chemical Industries, Ltd.). Examples of rosin-based resins include hydrogenated rosin glycerol ester, ultra-pale rosin, ultra-pale rosin ester, and acid-modified ultra-pale rosin. More specifically, examples include Pine Crystal (KE-311, PE-590, KE-359, KE-100, etc.) (trade name, manufactured by Arakawa Chemical Industries, Ltd.). The tackifying resin may be one of these alone or two or more in combination. Among these, alicyclic saturated hydrocarbon resins, terpene resins, hydrogenated rosin glycerol ester, or combinations thereof are preferred, and alicyclic saturated hydrocarbon resins, terpene resins, or combinations thereof are more preferred.
[0044] Examples of plasticizers include liquid paraffin, light liquid paraffin, squalane, squalene, vegetable oils (olive oil, camellia oil, castor oil, tall oil, peanut oil, spearmint oil, eucalyptus oil, jojoba oil, camphor oil, sunflower oil, orange oil, etc.), fats and oils (dibutyl phthalate, dioctyl phthalate, etc.), and liquid rubbers (liquid polybutene, liquid isoprene rubber, etc.).
[0045] The absorption enhancer can be any compound conventionally known to have transdermal absorption-enhancing properties. Examples of absorption enhancers include organic acid esters (e.g., fatty acid esters, cinnamic acid esters), organic acid amides (e.g., fatty acid amides), aliphatic alcohols, polyhydric alcohols, and ethers (e.g., aliphatic ethers, polyoxyethylene alkyl ethers). These absorption enhancers may have unsaturated bonds and may have cyclic, linear, or branched chemical structures. The absorption enhancer may also be a monoterpene compound, a sesquiterpene compound, or a vegetable oil (e.g., olive oil). These absorption enhancers may be used individually or in combination of two or more.
[0046] Examples of organic acid esters include ethyl acetate, propyl acetate, cetyl lactate, lauryl lactate, methyl salicylate, ethylene glycol salicylate, methyl cinnamate, and fatty acid esters. Examples of fatty acid esters include methyl laurate, hexyl laurate, isopropyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, and cetyl palmitate. Fatty acid esters may also be glycerin fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters, polyethylene glycol sorbitan fatty acid esters, polyethylene glycol fatty acid esters, sucrose fatty acid esters, or polyoxyethylene hydrogenated castor oil. Specific examples of fatty acid esters include glycerin monocaprylate, glycerin monocaprate, glycerin monolaurate, glycerin monooleate, sorbitan monolaurate, sucrose monolaurate, polysorbate 20, propylene glycol monolaurate, polyethylene glycol monolaurate, polyethylene glycol monostearate, Span 40, Span 60, Span 80, Span 120 (product names, manufactured by Croda Japan Co., Ltd.), Tween® 20, Tween® 21, Tween® 40, Tween® 60, Tween® 80, and NIKKOL® HCO-60 (product name, manufactured by Nikko Chemicals Co., Ltd.).
[0047] Examples of organic acid amides include fatty acid amides (e.g., lauric acid diethanolamide), hexahydro-1-dodecyl-2H-azepine-2-one (also known as Azone) and its derivatives, and pyrothiodecane.
[0048] Aliphatic alcohols refer to alcohols with 6 to 20 carbon atoms. Examples of aliphatic alcohols include lauryl alcohol, myristyl alcohol, oleyl alcohol, isostearyl alcohol, and cetyl alcohol. An example of a polyhydric alcohol is propylene glycol.
[0049] Aliphatic ethers refer to ethers having an aliphatic group (e.g., alkyl or alkenyl group) with 6 to 20 carbon atoms. An example of a polyoxyethylene alkyl ether is polyoxyethylene lauryl ether.
[0050] Examples of monoterpene compounds include geraniol, thymol, terpineol, l-menthol, borneol, d-limonene, isoborneol, nerol, and dl-camphor. Peppermint oil may also be used as a monoterpene compound.
[0051] The solubilizer is a component that facilitates the dissolution of bisoprolol or a pharmaceutically acceptable salt thereof in the adhesive composition. Examples of solubilizers include fatty acid polyhydric alcohol esters (e.g., propylene glycol monolaurate, glyceryl monolaurate, glyceryl monooleate, sorbitan monolaurate), fatty acid amides (e.g., diethanolamide laurate), aliphatic alcohols (e.g., octyldodecanol, isostearyl alcohol, oleyl alcohol), polyhydric alcohols (e.g., propylene glycol, dipropylene glycol, polyethylene glycol), and pyrrolidone derivatives (e.g., N-methyl-2-pyrrolidone).
[0052] Examples of fillers include powders of metal compounds (aluminum oxide, aluminum hydroxide, zinc oxide, titanium dioxide, calcium carbonate, etc.) or organic compounds (cellulose powder, stearate, etc.), or short fibers of resins containing these.
[0053] The material of the release liner 16 is not particularly limited, and liners made of materials generally known to those skilled in the art can be used. Examples of materials for the release liner 16 include polyethylene, polypropylene, polybutylene, polyethylene terephthalate, rayon, polyurethane, and paper. These materials may be used individually or in combination of two or more. Polypropylene film is preferred as the material for the release liner 16.
[0054] [Perforation Structure] The adhesive sheet 10 further comprises one or more perforations, each formed to connect two different points on the outer edge OE of the adhesive sheet 10. The outer edge OE is the outer edge of the adhesive sheet 10 in a plan view. As an example, the adhesive sheet 10 comprises a first perforation 20 formed to connect two points P1 located on a pair of short sides of the adhesive sheet 10, and a second perforation 50 formed to connect two points P2 located on a pair of long sides of the adhesive sheet 10. Point P1 is located at the center of the short side, and point P2 is located at the center of the long side. The first perforation 20 extends linearly along the longitudinal direction X at the center of the adhesive sheet 10 in the short direction Y. The second perforation 50 extends linearly along the short direction Y at the center of the adhesive sheet 10 in the longitudinal direction X. Therefore, the first perforation 20 and the second perforation 50 are orthogonal to each other.
[0055] In the example shown in Figure 2, the adhesive sheet 10 can be divided into four equal parts by cutting along the first perforation 20 and the second perforation 50. The adhesive sheet 10 may also be divided into two equal parts by cutting along either the first perforation 20 or the second perforation 50. In this way, the adhesive sheet 10 is cut according to the size of the area to be attached. The adhesive sheet 10 may be attached with at least a portion of the perforations remaining. For example, the adhesive sheet 10 may be attached with a portion of the first perforation 20 cut and the rest of the first perforation 20 not cut. The adhesive sheet 10 may be attached with a portion of the second perforation 50 cut and the rest of the second perforation 50 not cut.
[0056] The first perforation 20 is provided at predetermined intervals and has a plurality of first cuts 30 that penetrate the support 12, the adhesive layer 14, and the release liner 16, and a plurality of first joints 40, each forming the predetermined interval. That is, the first cuts 30 and the first joints 40 are arranged alternately with each other.
[0057] The multiple first cuts 30 include a pair of first outermost cuts 31 (the outermost cut and another outermost cut), a first central cut 32, and multiple first normal cuts 33.
[0058] The pair of first outermost cuts 31 are the cuts closest to the two points P1, respectively. For example, the pair of first outermost cuts 31 each reach the two points P1. The pair of first outermost cuts 31 are located at both ends of the multiple first cuts 30.
[0059] The first central cut 32 is a cut located in the center of the adhesive sheet 10 in a plan view. The first central cut 32 intersects with the cut of the second perforation 50 (the second central cut 62 in the example of Figure 2). For example, the first central cut 32 is perpendicular to the second central cut 62.
[0060] The multiple first normal cuts 33 are cuts among the multiple first cuts 30 other than the first outermost cut 31 and the first central cut 32. The multiple first normal cuts 33 are located inside the adhesive sheet 10 from the pair of first outermost cuts 31. For example, the multiple first normal cuts 33 are located between one first outermost cut 31 and the first central cut 32, and between the other first outermost cut 31 and the first central cut 32. The multiple first normal cuts 33 each have a pair of cuts 331 adjacent to the pair of first outermost cuts 31. The pair of cuts 331 are the second closest cuts to the two points P1. The multiple first normal cuts 33 each have a pair of cuts 332 adjacent to the first central cut 32 on both outer sides of the first central cut 32.
[0061] The multiple first joints 40 include a pair of first outer joints 41 (outer joint and other outer joints), a pair of subsequent first outer joints 42, a pair of first central joints 43 (first central joint and other first central joints), a pair of subsequent first central joints 44, and a plurality of first normal joints 45.
[0062] The pair of first outer joints 41 are joints located at both ends of the plurality of first joints 40. Each of the pair of first outer joints 41 connects to the respective inner ends of the pair of first outermost cuts 31. The first outer joints 41 are sandwiched between the first outermost cuts 31 and cuts 331.
[0063] Each of the pair of next first outer joints 42 is adjacent to each of the pair of first outer joints 41. Each of the pair of next first outer joints 42 connects to each of the inner ends of the pair of cuts 331. The next first outer joints 42, together with the first outer joints 41, sandwich the cuts 331.
[0064] The pair of first central seams 43 are seams located in the center of the adhesive sheet 10 in a plan view. One of the first central seams 43 connects to one end of the first central cut 32 on the side of one of the first outermost cuts 31. The other first central seam 43 connects to the other end of the first central cut 32 on the side of the other first outermost cut 31. In other words, the pair of first central seams 43 sandwich the first central cut 32. The first central seams 43 are sandwiched between the first central cut 32 and the cut 332.
[0065] Each of the pair of next first central joints 44 is adjacent to each of the pair of first central joints 43. One of the next first central joints 44 is adjacent to one of the first central joints 43 on the side of one of the first outermost cuts 31 (opposite to the first central cut 32). The other next first central joint 44 is adjacent to the other first central joint 43 on the side of the other first outermost cut 31 (opposite to the first central cut 32). Each of the pair of next first central joints 44 is connected to the respective outer ends of the pair of cuts 332. The next first central joints 44, together with the first central joints 43, sandwich the cut 332.
[0066] The multiple first normal joints 45 are joints from the multiple first joints 40 other than the first outer joint 41, the next first outer joint 42, the first central joint 43, and the next first central joint 44. The multiple first normal joints 45 are located inside the adhesive sheet 10 beyond the pair of next first outer joints 42. For example, the multiple first normal joints 45 are located between one next first outer joint 42 and one next first central joint 44, and between the other next first outer joint 42 and the other next first central joint 44.
[0067] Next, the dimensions of the first perforation 20 will be described. In the following description, the lengths of the first outermost cut 31, the first central cut 32, and the first normal cut 33 along the longitudinal direction X will be denoted as lengths L11, L12, and L13, respectively. The lengths of the first outer seam 41, the next first outer seam 42, the first central seam 43, the next first central seam 44, and the first normal seam 45 along the longitudinal direction X will be denoted as lengths L21, L22, L23, L24, and L25, respectively.
[0068] The length L11 of the first outermost cut 31 is greater than the length L13 of the first normal cut 33. Half the length of the first central cut 32 (i.e., L12 / 2) is greater than the length L13 of the first normal cut 33. For example, the length L11 of the first outermost cut 31 and half the length L12 / 2 of the first central cut 32 are the same. For example, the lengths L13 of multiple first normal cuts 33 are the same.
[0069] The length L11 of the first outermost cut 31 may be 1.3 mm to 2.7 mm or 1.5 mm to 2.5 mm. The length L12 of the first central cut 32 may be 2.6 mm to 5.4 mm or 3.0 mm to 5.0 mm. The length L13 of the first normal cut 33 may be 0.8 mm to 2.2 mm or 1.0 mm to 2.0 mm.
[0070] The length L21 of the first outer joint 41 may be the same as the length L25 of the first normal joint 45, or it may be greater than the length L25 of the first normal joint 45. The length L22 of the next first outer joint 42 may be the same as the length L25 of the first normal joint 45, or it may be greater than the length L25 of the first normal joint 45. The length L23 of the first central joint 43 may be the same as the length L25 of the first normal joint 45, or it may be greater than the length L25 of the first normal joint 45. The length L24 of the next first central joint 44 may be the same as the length L25 of the first normal joint 45, or it may be greater than the length L25 of the first normal joint 45. As an example, the length L21 of the first outer joint 41, the length L22 of the next first outer joint 42, the length L23 of the first central joint 43, and the length L24 of the next first central joint 44 are all the same. For example, the lengths L25 of each of the multiple first normal joints 45 are the same.
[0071] The length L21 of the first outer joint 41, the length L22 of the next first outer joint 42, the length L23 of the first central joint 43, and the length L24 of the next first central joint 44 may be 0.8 mm to 2.2 mm, 1.0 mm to 2.0 mm, 1.5 mm to 2.2 mm, or 1.7 mm to 2.0 mm. The length L25 of the first normal joint 45 may be 0.6 mm to 1.2 mm or 0.8 mm to 1.0 mm.
[0072] The width of each of the multiple first cuts 30 along the shorter direction Y, and the width of each of the multiple first joints 40 along the shorter direction Y, may be 0.03 mm to 0.09 mm or 0.05 mm to 0.07 mm.
[0073] The second perforation 50 is provided at predetermined intervals and has a plurality of second cuts 60 that penetrate the support 12, the adhesive layer 14, and the release liner 16, and a plurality of second joints 70, each forming the predetermined interval. That is, the second cuts 60 and the second joints 70 are arranged alternately with each other.
[0074] The multiple second cuts 60 include a pair of second outermost cuts 61 (the outermost cut and another outermost cut), a second central cut 62, and multiple second normal cuts 63.
[0075] The pair of second outermost cuts 61 are the cuts closest to the two points P2, respectively. For example, the pair of second outermost cuts 61 each reach the two points P2. The pair of second outermost cuts 61 are located at both ends of the multiple second cuts 60.
[0076] The second central cut 62 is a cut located in the center of the adhesive sheet 10 in a plan view. The second central cut 62 intersects with the cut of the first perforation 20 (the first central cut 32 in the example of Figure 2).
[0077] The multiple second normal cuts 63 are cuts among the multiple second cuts 60 other than the second outermost cut 61 and the second central cut 62. The multiple second normal cuts 63 are located inside the adhesive sheet 10 from the pair of second outermost cuts 61. For example, the multiple second normal cuts 63 are located between one second outermost cut 61 and the second central cut 62, and between the other second outermost cut 61 and the second central cut 62. The multiple second normal cuts 63 each have a pair of cuts 631 adjacent to the pair of second outermost cuts 61. The pair of cuts 631 are the second closest cuts to the two points P2. The multiple second normal cuts 63 have a pair of cuts 632 adjacent to the second central cut 62 on both outer sides of the second central cut 62.
[0078] The multiple second joints 70 include a pair of second outer joints 71 (outer joint and other outer joints), a pair of subsequent second outer joints 72, a pair of second central joints 73 (second central joint and other second central joints), a pair of subsequent second central joints 74, and multiple second normal joints 75.
[0079] The pair of second outer joints 71 are joints located at both ends of the plurality of second joints 70. Each of the pair of second outer joints 71 connects to the respective inner ends of the pair of second outermost cuts 61. The second outer joints 71 are sandwiched between the second outermost cuts 61 and cuts 631.
[0080] Each of the pair of next second outer joints 72 is adjacent to each of the pair of second outer joints 71. Each of the pair of next second outer joints 72 connects to each of the inner ends of the pair of cuts 631. The next second outer joints 72, together with the second outer joints 71, sandwich the cuts 631.
[0081] The pair of second central seams 73 are seams located in the center of the adhesive sheet 10 in a plan view. One second central seam 73 connects to one end of the second central cut 62 on the side of one second outermost cut 61. The other second central seam 73 connects to the other end of the second central cut 62 on the side of the other second outermost cut 61. In other words, the pair of second central seams 73 sandwich the second central cut 62. The second central seams 73 are sandwiched between the second central cut 62 and the cut 632.
[0082] Each of the pair of next second central joints 74 is adjacent to each of the pair of second central joints 73. One of the next second central joints 74 is adjacent to one of the second central joints 73 on the side of one of the second outermost cuts 61 (opposite to the second central cut 62). The other next second central joint 74 is adjacent to the other second central joint 73 on the side of the other second outermost cut 61 (opposite to the second central cut 62). Each of the pair of next second central joints 74 connects to the respective outer ends of the pair of cuts 632. The next second central joints 74, together with the second central joints 73, sandwich the cut 632.
[0083] The multiple second normal joints 75 are joints from the multiple second joints 70 other than the second outer joint 71, the next second outer joint 72, the second central joint 73, and the next second central joint 74. The multiple second normal joints 75 are located inside the adhesive sheet 10 beyond the pair of next second outer joints 72. For example, the multiple second normal joints 75 are located between one next second outer joint 72 and one next second central joint 74, and between the other next second outer joint 72 and the other next second central joint 74.
[0084] Next, the dimensions of the second perforation 50 will be described. In the following description, the lengths of the second outermost cut 61, the second central cut 62, and the second normal cut 63 along the shorter direction Y will be denoted as lengths L31, L32, and L33, respectively. The lengths of the second outer seam 71, the next second outer seam 72, the second central seam 73, the next second central seam 74, and the second normal seam 75 along the shorter direction Y will be denoted as lengths L41, L42, L43, L44, and L45, respectively.
[0085] The length L31 of the second outermost cut 61 is greater than the length L33 of the second normal cut 63. Half the length of the second central cut 62 (i.e., L32 / 2) is greater than the length L33 of the second normal cut 63. For example, the length L31 of the second outermost cut 61 and half the length L32 / 2 of the second central cut 62 are the same. For example, the lengths L33 of multiple second normal cuts 63 are the same. The length of the second outermost cut 61 and half the length of the second central cut 62 may be greater than the length of the first outermost cut 31 and half the length of the first central cut 32.
[0086] The length L31 of the second outermost cut 61 may be 1.3 mm to 3.2 mm or 1.5 mm to 3.0 mm. The length L32 of the second central cut 62 may be 2.6 mm to 6.4 mm or 3.0 mm to 6.0 mm. The length L33 of the second normal cut 63 may be 0.8 mm to 2.2 mm or 1.0 mm to 2.0 mm.
[0087] The length L41 of the second outer joint 71 may be the same as the length L45 of the second normal joint 75, or it may be greater than the length L45 of the second normal joint 75. The length L42 of the next second outer joint 72 may be the same as the length L45 of the second normal joint 75, or it may be greater than the length L45 of the second normal joint 75. The length L43 of the second central joint 73 may be the same as the length L45 of the second normal joint 75, or it may be greater than the length L45 of the second normal joint 75. The length L44 of the next second central joint 74 may be the same as the length L45 of the second normal joint 75, or it may be greater than the length L45 of the second normal joint 75. As an example, the length L41 of the second outer joint 71, the length L42 of the next second outer joint 72, the length L43 of the second central joint 73, and the length L44 of the next second central joint 74 are all the same. For example, the lengths L45 of each of the multiple second normal joints 75 are the same.
[0088] The length L41 of the second outer joint 71, the length L42 of the next second outer joint 72, the length L43 of the second central joint 73, and the length L44 of the next second central joint 74 may be 0.8 mm to 2.2 mm, 1.0 mm to 2.0 mm, 1.5 mm to 2.2 mm, or 1.7 mm to 2.0 mm. The length L45 of the second normal joint 75 may be 0.6 mm to 1.2 mm or 0.8 mm to 1.0 mm.
[0089] The width of each of the multiple second cuts 60 along the longitudinal direction X, and the width of each of the multiple second joints 70 along the longitudinal direction X, may be 0.03 mm to 0.09 mm or 0.05 mm to 0.07 mm.
[0090] [Breaking Strength] The breaking strength of the support 12 can be measured by the following <Method for Measuring the Breaking Strength of the Support 12>. This measurement method measures the maximum load point and the elongation at the breaking point of the support 12 in a state where no perforations have been formed. The test information regarding the testing machine used for the measurement is as follows: <Test Information> ・Test machine name: Tensilon Tensile Testing Machine RTA-100 (A&D Co., Ltd.) ・Test type: Tensile test ・Load cell rating: 1000 [N] ・Test speed: 300 [mm / min] ・Control method: Constant movement speed control
[0091] <Method for measuring the breaking strength of the support 12> (1) The support 12 is punched out into strip-shaped test pieces measuring 10 cm in height and 2 cm in width. As mentioned above, these test pieces do not have perforations. (2) The starting point is set so that the distance between the chucks of the testing machine is 6 cm. (3) The upper end of the test piece is fixed by clamping it in the upper chuck. (4) The test piece is pulled by hand to the extent that there is no slack, and the lower end of the test piece is fixed by clamping it in the lower chuck. (5) A load is applied at a tensile speed of 300 [mm / min] until the test piece breaks. (6) The strength of the test piece at the maximum load and the elongation at the maximum load are measured, and the elongation at the breaking point is determined from this elongation. (7) The maximum load point and the elongation at the breaking point are determined for each of the three test pieces, and the average value of each of these two indicators is calculated.
[0092] The maximum load point of the support 12 may be 5N to 28N or 6N to 27N. By setting the lower limit of the maximum load point of the support 12 as described above, the strength of the support 12 can be maintained and unintended cutting of the adhesive sheet 10 can be suppressed. By setting the upper limit of the maximum load point of the support 12 as described above, the strength of the support 12 can not be increased too much and the ease with which the adhesive sheet 10 can be torn by hand can be improved.
[0093] The elongation at the breaking point of the support 12 may be 20%GL to 33%GL or 23%GL to 32%GL. By setting the lower limit of the elongation at the breaking point of the support 12 as described above, the elasticity of the support 12 can be maintained and unintended cutting of the adhesive sheet 10 can be suppressed. By setting the upper limit of the elongation at the breaking point of the support 12 as described above, excessive stretching of the support 12 can be suppressed and the tearability of the adhesive sheet 10 can be improved. %GL of the elongation at the breaking point means % gauge length, i.e., the ratio to the distance between gauge points.
[0094] The breaking strength of the adhesive sheet 10 can be measured by the <Method for Measuring the Breaking Strength of the Adhesive Sheet 10> described below. The test information in this measurement is the same as the <Test Information> used in the measurement of the breaking strength of the support 12.
[0095] <Method for measuring the breaking strength of the adhesive sheet 10> (1) Place the formulation (adhesive sheet 10) in a test chamber (25°C, 55% RH) for 12 hours or more to allow the formulation to acclimate. (2) Remove the formulation from the packaging and punch out a strip-shaped test piece measuring 10 cm in height and 2 cm in width from the removed formulation. The test piece has a perforation running along the width direction in the center of the height direction. (3) Set the starting point so that the distance between the chucks of the testing machine is 6 cm. (4) Secure the upper end of the test piece by clamping it in the upper chuck. (5) Pull the test piece by hand to the extent that there is no slack, and secure the lower end of the test piece by clamping it in the lower chuck so that the perforation is 2.5 cm from the end of the upper chuck. (6) Apply a load at a tensile speed of 300 [mm / min] until the test piece breaks. (7) Measure the strength and elongation of the test specimen at maximum load, and determine the elongation at fracture from this elongation. (8) Determine the maximum load point and elongation at fracture for each of the three test specimens, and calculate the average value for each of these two indicators.
[0096] Figure 3 shows a test specimen used to measure the breaking strength of the adhesive sheet 10. In the example in Figure 3, three test specimens (end pieces) 201 and three test specimens (center pieces) 202 are punched out from one adhesive sheet 10. The test specimen (end piece) 201 is a test specimen in which one of its long sides (a side with a length of 10 cm) coincides with the short side of the adhesive sheet 10 or the second perforation 50. The test specimen (center piece) 202 is a test specimen that does not touch the short side of the adhesive sheet 10 or the second perforation 50, but is located between the short side of the adhesive sheet 10 and the second perforation 50. The maximum load point and the elongation at the breaking point of the test specimen (end piece) 201 and the test specimen (center piece) 202 can be determined by the above measurement method.
[0097] [Function and Effects] In the adhesive sheet 10, the length L21 of the first outer seam 41 is greater than the length L25 of the first normal seam 45. Because the length of the first outer seam 41 located around the first outermost cut 31 is relatively large, when the adhesive sheet 10 is applied with the first outermost cut 31 remaining, it is possible to suppress the cutting of the adhesive sheet 10 starting from the first outermost cut 31. Therefore, the adhesive sheet 10 can suppress unintended cutting.
[0098] In the adhesive sheet 10, the length L11 of the first outermost cut 31 is greater than the length L13 of the first normal cut 33. Because the length of the first outermost cut 31 is relatively large, the adhesive sheet 10 can be easily cut starting from the first outermost cut 31. Therefore, the adhesive sheet 10 can be made easier to tear by hand.
[0099] In the adhesive sheet 10, the length L22 of the next first outer seam 42 is greater than the length L25 of the first normal seam 45. This makes it possible to further suppress unintended cutting of the adhesive sheet 10 starting from the first outermost cut 31.
[0100] In the adhesive sheet 10, the length L12 / 2 of half the length of the first central cut 32 is greater than the length L13 of the first normal cut 33, and the length L23 of the first central seam 43 is greater than the length L25 of the first normal seam 45. Because the length of the first central cut 32 is relatively large, the adhesive sheet 10 can be easily cut starting from the first central cut 32. On the other hand, because the length of the first central seam 43 located around the first central cut 32 is relatively large, if the adhesive sheet 10 is applied with the first central cut 32 remaining intact, cutting of the adhesive sheet 10 starting from the first central cut 32 can be suppressed.
[0101] In the adhesive sheet 10, the length L24 of the next first central seam 44 is greater than the length L25 of the first normal seam 45. This makes it possible to further suppress unintended cutting of the adhesive sheet 10 starting from the first central cut 32.
[0102] In the adhesive sheet 10, the length L32 / 2 of half the second central cut 62 is greater than the length L33 of the second normal cut 63, and the length L43 of the second central seam 73 is greater than the length L45 of the second normal seam 75. Because the length of the second central cut 62 is relatively large, the adhesive sheet 10 can be easily cut starting from the second central cut 62. On the other hand, because the length of the second central seam 73 located around the second central cut 62 is relatively large, if the adhesive sheet 10 is applied with the second central cut 62 remaining intact, cutting of the adhesive sheet 10 starting from the second central cut 62 can be suppressed.
[0103] In the adhesive sheet 10, the first outermost cut 31 reaches the outer edge OE of the adhesive sheet 10. This makes it easier to cut the adhesive sheet 10 starting from the first outermost cut 31.
[0104] In the adhesive sheet 10, the length L11 of the first outermost cut 31 and the length L12 / 2 of half the first central cut 32 are greater than the length L13 of the first normal cut 33, and the length L31 of the second outermost cut 61 and the length L32 / 2 of half the second central cut 62 are greater than the length L33 of the second normal cut 63. For each of the first perforations 20 and the second perforations 50, by relatively increasing the length of the cut closest to the outer edge OE and the cut located in the region where the perforations intersect, it is possible to improve tearability by hand while suppressing unintended cuts. These two types of cuts, which are relatively longer, contribute to improved tearability by hand, while the normal cuts, which are relatively shorter, may contribute to suppressing unintended cuts.
[0105] In the adhesive sheet 10, the length L11 of the first outermost cut 31 may be 1.3 mm to 2.7 mm, the length L12 of the first central cut 32 may be 2.6 mm to 5.4 mm, the length L13 of the first normal cut 33 may be 0.8 mm to 2.2 mm, the length L31 of the second outermost cut 61 may be 1.3 mm to 3.2 mm, the length L32 of the second central cut 62 may be 2.6 mm to 6.4 mm, and the length L33 of the second normal cut 63 may be 0.8 mm to 2.2 mm. By setting the lengths of the cuts in this way, it is possible to improve tearability by hand while suppressing unintended cuts.
[0106] In the adhesive sheet 10, the lengths of the first outer seam 41, the next first outer seam 42, the first central seam 43, and the next first central seam 44 may be 1.5 mm to 2.2 mm, and the length of the first normal seam 45 may be 0.6 mm to 1.2 mm. By setting the seam lengths in this way, it is possible to improve tearability by hand while suppressing unintended cuts.
[0107] In the adhesive sheet 10, the lengths of the second outer seam 71, the next second outer seam 72, the second central seam 73, and the next second central seam 74 may be 1.5 mm to 2.2 mm, and the length of the second normal seam 75 may be 0.6 mm to 1.2 mm. By setting the seam lengths in this way, it is possible to improve tearability by hand while suppressing unintended cuts.
[0108] In the adhesive sheet 10, the length of the second outermost cut 61 and half the length of the second central cut 62 may be greater than the length of the first outermost cut 31 and half the length of the first central cut 32. In this case, it becomes easier to cut the adhesive sheet 10 along the second perforation 50.
[0109] In the adhesive sheet 10, the support 12 is formed from rayon pulp, and the elongation at the breaking point of the support 12 when no multiple cuts have been formed is, for example, 33% GL or less. By having the elongation at the breaking point of the support 12 formed from rayon pulp be 33% GL or less, it is possible to improve tearability by hand while suppressing unintended cuts.
[0110] In the adhesive sheet 10, the elongation at the breaking point of the support 12 when no multiple cuts have been formed may be 20% GL or more. In this case, the elasticity of the support 12 can be maintained, and unintended cutting of the adhesive sheet 10 can be suppressed.
[0111] In the adhesive sheet 10, the maximum load point of the support 12 when no multiple cuts have been formed may be between 5N and 28N. By setting the maximum load point in this way, the strength of the support 12 becomes appropriate, improving the ease of tearing the adhesive sheet 10 by hand while suppressing unintended cutting.
[0112] In the adhesive sheet 10, the density of the support 12 is 0.12 g / cm³. ３ It may be greater than this. By setting the density within this range, it tends to improve the tearability of the adhesive sheet 10 and suppress unintended cutting of the adhesive sheet 10.
[0113] [Variations] The technology relating to this disclosure has been described in detail above based on various examples. However, this disclosure is not limited to the above examples. Various modifications are possible to the technology relating to this disclosure without departing from its essence.
[0114] Figure 4 is a plan view of an adhesive sheet 10A according to a modified example, viewed from above. The adhesive sheet 10A differs from the adhesive sheet 10 in that the first outermost cut 31 and the second outermost cut 61 do not reach points P1 and P2, respectively. In addition to the first perforations 20, a pair of first adjustment cuts 130 may be formed on the adhesive sheet 10A. The pair of first adjustment cuts 130 are formed on both sides of the pair of first outermost cuts 31, spaced apart from them. The pair of first adjustment cuts 130 each reach two points P1. The first adjustment cuts 130 are formed, for example, to make a cut at point P1. The length of the first adjustment cuts 130 is shorter than the length of the first outermost cut 31.
[0115] The adhesive sheet 10A may have a pair of second adjustment cuts 160 formed in addition to the second perforations 50. The pair of second adjustment cuts 160 are formed on both sides of the pair of second outermost cuts 61, spaced apart from the pair of second outermost cuts 61. The pair of second adjustment cuts 160 reach two points P2, respectively. The second adjustment cuts 160 are formed, for example, to make a cut at point P2. The length of the second adjustment cuts 160 is less than the length of the second outermost cuts 61. With the adhesive sheet 10A, since the first outermost cut 31 and the second outermost cut 61 do not reach the outer edge OE, unintended cutting of the adhesive sheet 10A starting from the first outermost cut 31 and the second outermost cut 61 can be suppressed.
[0116] In the adhesive sheet 10, the first perforation 20 and the second perforation 50 were straight lines, but the first perforation 20 and the second perforation 50 may also be curved lines or lines that bend midway. The shape of the adhesive sheet 10 is not limited to a rectangle, but may also be a square, a circle, or an ellipse.
[0117] [Note] As can be seen from the various examples above, this disclosure includes the following embodiments: (Note 1) An adhesive sheet comprising: a support; an adhesive layer provided on the support; a release liner provided on the adhesive layer so as to sandwich the adhesive layer together with the support; and perforations, each having a plurality of cuts that penetrate the support, the adhesive layer, and the release liner, wherein the support is formed of rayon pulp, which is a mixture of rayon and pulp, and the elongation at the breaking point of the support when the plurality of cuts are not formed is 33% GL or less. (Note 2) The adhesive sheet according to Note 1, wherein the elongation at the breaking point of the support when the plurality of cuts are not formed is 20% GL or more. (Note 3) The adhesive sheet according to Note 1 or 2, wherein the maximum load point of the support when the plurality of cuts are not formed is 5 N to 28 N. (Note 4) The density of the support is 0.12 g / cm³ ３ The above applies to the adhesive sheet described in any one of the appendices 1 to 3.
[0118] The following describes specific examples, but this disclosure is not limited to them.
[0119] [Preparation of Adhesive Sheets (1)] The adhesive layers of the adhesive sheets according to Examples 1 and 2 and Comparative Examples 1 to 6 were prepared according to the following composition (unit: mass%): • Glycol salicylate 2.0 • l-Menthol 1.0 • Methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (Nicazole TS-620) 8.35 • Gelatin 2.6 • Partially neutralized polyacrylic acid 3.6 • Polyacrylic acid 3.5 • Polyvinyl alcohol (partially saponified) 2.5 • Concentrated glycerin 20.4 • D-sorbitol solution 7.0 • Sodium edetate hydrate 0.45 • Magnesium aluminometasilicate 0.35 • Other components 2.75 • Purified water 45.5
[0120] The adhesive sheets in Examples 1 and 2 used the support shown in Table 1 below, the adhesive sheets in Comparative Examples 1 to 3 used the support shown in Table 2 below, and the adhesive sheets in Comparative Examples 4 to 6 used the support shown in Table 3 below. The maximum load point and elongation at the breaking point shown in Tables 1 to 3 were measured according to the <Method for measuring the breaking strength of the support 12> described above.
[0121]
[0122]
[0123]
[0124] The perforations of the adhesive sheets in Examples 1 and 2 and Comparative Examples 1 to 6 were formed according to the following dimensions (unit: mm): • Length of the first outermost cut: 2.5 • Length of the first central cut: 5.0 • Length of the first normal cut: 2.0 • Length of the first outer seam and the next first outer seam: 2.0 • Length of the first central seam and the next first central seam: 2.0 • Length of the first normal seam: 1.0 • Length of the second outermost cut: 3.0 • Length of the second central cut: 6.0 • Length of the second normal cut: 2.0 • Length of the second outer seam and the next second outer seam: 2.0 • Length of the second central seam and the next second central seam: 2.0 • Length of the second normal seam: 1.0 • Width of each cut and seam: 0.05 to 0.07
[0125] For the adhesive sheets used in Examples 1 and 2 and Comparative Examples 1 to 6, adhesive sheets with a long side of 140 mm and a short side of 100 mm were prepared.
[0126] [Evaluation (1)] <Sensory Evaluation (1)> Sensory evaluations were conducted on the adhesive sheets of Examples 1 and 2 and Comparative Examples 1 to 6 regarding "ease of tearing by hand," "condition of the cut edge of the adhesive sheet after tearing by hand," and "condition of the adhesive sheet during application" according to the evaluation criteria shown below. The final score was obtained by averaging the scores of the eight evaluators. For "condition of the adhesive sheet during application," the adhesive sheet was cut in half along the first perforation, and the halved adhesive sheet was applied to the wrist for evaluation. In this way, the condition of the adhesive sheet during application was evaluated with a portion of the second perforation remaining on the halved adhesive sheet.
[0127] (Ease of cutting by hand) 4 points: The adhesive sheet could be cut easily. 3 points: The adhesive sheet could be cut, but not easily. 2 points: The adhesive sheet could be cut, but with difficulty. 1 point: The adhesive sheet could not be cut.
[0128] (Condition of the cut edge of the adhesive sheet after hand cutting) 5 points: No fuzzing (fuzzing less than 1 mm from the edge of the product) 4 points: Slight fuzzing (not noticeable) (fuzzing 1 mm to less than 5 mm from the edge of the product) 3 points: Some fuzzing (fuzzing 5 mm to less than 10 mm from the edge of the product) 2 points: Fuzzing (fuzzing 10 mm to less than 15 mm from the edge of the product) 1 point: Quite a bit of fuzzing (fuzzing 15 mm or more from the edge of the product)
[0129] (Condition of the adhesive sheet during application) 3 points: The perforations did not tear during application. 2 points: Some of the perforations tore during application, leaving a gap. 1 point: The perforations tore completely during application.
[0130] The results of the sensory evaluation are shown in Table 4 below. For the evaluation of "the condition of the cut edge of the adhesive sheet after hand-cutting" in Comparative Examples 1 to 3, the average score of the evaluations from evaluators who were able to cut the adhesive sheet by hand (Comparative Example 1: 2 people, Comparative Example 2: 3 people, Comparative Example 3: 7 people) was used. In Comparative Examples 1 to 3, both "ease of hand-cutting" and "the condition of the cut edge of the adhesive sheet after hand-cutting" were less than 3 points, indicating poor hand-cutting ability. In Comparative Examples 4 to 6, "the condition of the cut edge of the adhesive sheet after hand-cutting" was less than 3 points, indicating poor hand-cutting ability. In Comparative Example 3, "the condition of the adhesive sheet during application" was less than 3 points, indicating that unintended cutting of the adhesive sheet during application was not sufficiently suppressed. In contrast, in Examples 1 and 2, both "ease of hand-cutting" and "the condition of the cut edge of the adhesive sheet after hand-cutting" were 3 points or higher, indicating excellent hand-cutting ability. Also, in Examples 1 and 2, "the condition of the adhesive sheet during application" was 3 points, indicating that unintended cutting of the adhesive sheet during application was suppressed.
[0131]
[0132] <Physical Property Test (1)> For the adhesive sheets according to Examples 1 and 2 and Comparative Examples 1 to 6, the maximum load point (unit: N) and the elongation at the breaking point (unit: %GL) of the test specimen (edge) and test specimen (center) were measured according to the <Method for Measuring the Breaking Strength of Adhesive Sheet 10> described above. The results are shown in Table 5 below.
[0133]
[0134] [Preparation of Adhesive Sheets (2)] The adhesive layers of the adhesive sheets according to Examples 3-5 and Reference Examples 1 and 2 were prepared according to the following composition (unit: mass%): • Glycol salicylate 2.0 • l-Menthol 1.0 • Methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (Nicazole TS-620) 8.35 • Gelatin 2.6 • Partially neutralized polyacrylic acid 3.6 • Polyacrylic acid 3.5 • Polyvinyl alcohol (partially saponified) 2.5 • Concentrated glycerin 20.4 • D-sorbitol solution 7.0 • Sodium edetate hydrate 0.45 • Magnesium aluminometasilicate 0.35 • Other components 2.75 • Purified water 45.5
[0135] In the adhesive sheets of Examples 3-5 and Reference Examples 1 and 2, the support shown below was used. The maximum load point and elongation at the breaking point were measured according to the <Method for measuring the breaking strength of the support 12> described above. • Material: Rayon pulp • Thickness (mm): 0.57 • Basis weight (g / m²) ２ ): 79.9 ・Density (g / cm ３ ): 0.14 • Maximum load point (N): 26.88 • Elongation at breaking point (%GL): 31.52 • Manufacturing method: Wet process
[0136] The perforations on the adhesive sheets according to Examples 3-5 and Reference Examples 1 and 2 were formed according to the dimensions (unit: mm) shown in Table 6 below.
[0137]
[0138] For the adhesive sheets used in Examples 3 to 5 and Reference Examples 1 and 2, adhesive sheets with a long side of 140 mm and a short side of 100 mm were prepared.
[0139] [Evaluation (2)] <Sensory Evaluation (2)> Sensory evaluation was conducted on the adhesive sheets according to Examples 3 to 5 and Reference Examples 1 and 2 regarding "ease of tearing by hand," "condition of the cut edge of the adhesive sheet after tearing by hand," and "condition of the adhesive sheet during application." The evaluation criteria and evaluation methods were the same as those for <Sensory Evaluation (1)> above.
[0140] The results of the sensory evaluation are shown in Table 7 below. In Reference Examples 1 and 2, the "condition of the adhesive sheet during application" was less than 3 points, indicating that unintended cutting of the adhesive sheet during application was not sufficiently suppressed. In contrast, in Examples 3 to 5, both "ease of tearing by hand" and "condition of the cut edge of the adhesive sheet after tearing by hand" were 3 points or higher, indicating excellent ease of tearing by hand. Furthermore, in Examples 3 to 5, the "condition of the adhesive sheet during application" was 3 points, indicating that unintended cutting of the adhesive sheet during application was suppressed.
[0141]
[0142] <Physical Property Test (2)> For the adhesive sheets according to Examples 3 to 5 and Reference Examples 1 and 2, the maximum load point (unit: N) and the elongation at the breaking point (unit: %GL) of the test specimen (end) and test specimen (center) were measured according to the <Method for Measuring the Breaking Strength of Adhesive Sheet 10> described above. The results are shown in Table 8 below.
[0143]
[0144] 10, 10A...Adhesive sheet, 12...Support, 14...Adhesive layer, 16...Release liner, 20...First perforation, 30...First cut, 31...First outermost cut, 32...First central cut, 33...First normal cut, 40...First seam, 41...First outer seam, 42...Next first outer seam, 43...First central seam, 44...Next first central seam, 45...First normal seam, 50...Second perforation, 60...Second cut, 61...Second outermost cut, 62...Second central cut, 63...Second normal cut, 70...Second seam, 71...Second outer seam, 72...Next second outer seam, 73...Second central seam, 74...Next second central seam, 75...Second normal seam, OE...Outer edge, P1, P2...Points on the outer edge.
Claims
1. An adhesive sheet comprising: a support; an adhesive layer provided on the support; a release liner provided on the adhesive layer so as to sandwich the adhesive layer together with the support; and perforations having a plurality of cuts that penetrate the support, the adhesive layer, and the release liner, wherein the support is formed of rayon pulp which is a mixture of rayon and pulp, and the elongation at the breaking point of the support in a state where the plurality of cuts are not formed is 33% GL or less.
2. The adhesive sheet according to claim 1, wherein the elongation at the breaking point of the support in a state where the plurality of cuts are not formed is 20% GL or more.
3. The adhesive sheet according to claim 1 or 2, wherein the maximum load point of the support when the plurality of cuts are not formed is 5N to 28N.
4. The density of the support is 0.12 g / cm³. ３ The adhesive sheet according to claim 1 or 2.