Adhesive sheet and poultice

Abstract

Disclosed is an adhesive sheet comprising a support layer, an adhesive layer which is layered on the support layer, and a release liner which is provided on a surface opposite to the support layer with respect to the adhesive layer, wherein: the adhesive layer contains water, a neutralized product of polyacrylic acid, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion; the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 1.5-15 mass% based on the total mass of the adhesive layer; and the support layer is made of a rayon pulp nonwoven fabric which has a maximum load point of not less than 8 N and an elongation at break of not more than 40% GL.

Description

Adhesive sheets and poultices

[0001] The present invention relates to adhesive sheets, and more particularly to water-containing adhesive sheets and poultices.

[0002] A water-containing adhesive sheet is manufactured by spreading an adhesive layer on a support layer such as cloth. In addition to water, the adhesive layer contains water-soluble polymers such as gelatin, polyacrylic acid, neutralized polyacrylic acid, and polyvinyl alcohol to ensure shape retention and cohesiveness.

[0003] Poultices are a type of adhesive patch manufactured by spreading a drug-containing adhesive layer on a support layer such as cloth. Generally, the adhesive layer has a high water content and contains water-soluble polymers such as gelatin, polyacrylic acid, neutralized polyacrylic acid, and polyvinyl alcohol.

[0004] Patent Document 1 proposes a poultice that is less likely to peel off even when applied for a long time, and that further reduces the pain caused when it is removed.

[0005] Japanese Patent Publication No. 2019-156736

[0006] In developing adhesive sheets and poultices for use wrapped around fingers or wrists, the inventors discovered that conventional poultices have insufficient adhesion, which can cause the adhesive layer to peel off the skin and / or support layer to which it is applied.

[0007] The present invention has been made in view of the problems of the prior art described above, and aims to provide an adhesive sheet and a poultice to which the adhesive layer does not easily peel off the skin and / or support layer when used wrapped around a finger or wrist.

[0008] As a result of diligent research to achieve the above objective, the present inventors have discovered that by providing an adhesive sheet and a poultice comprising a support layer made of rayon pulp nonwoven fabric having predetermined physical properties, and an adhesive layer containing water, polyacrylic acid neutralized product, and methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, and by setting the content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion within a predetermined range, it is possible to provide an adhesive sheet and a poultice in which the adhesive layer is less likely to peel off from the skin or support layer even when wrapped around a finger or wrist, etc., thus completing the present invention.

[0009] In other words, the present invention includes the following [1] to [4]. [1] An adhesive sheet comprising a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side opposite to the support layer relative to the adhesive layer, wherein the adhesive layer contains water, a polyacrylic acid neutralized product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, and the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less. [2] The adhesive sheet according to [1], wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 30% GL or more and an elongation at the breaking point of 40% GL or less. [3] A poultice comprising a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side of the adhesive layer opposite to the support layer, wherein the adhesive layer contains a drug, water, a polyacrylic acid neutralized product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, and the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less. [4] The poultice according to [3], wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 30% GL or more and an elongation at the breaking point of 40% GL or less.

[0010] According to the present invention, it is possible to provide an adhesive sheet and a poultice to which the adhesive layer is difficult to peel off from the skin and / or support layer when used wrapped around a finger or wrist.

[0011] Preferred embodiments of the present invention will be described in detail below.

[0012] An adhesive sheet according to the first embodiment of the present invention comprises a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side of the adhesive layer opposite to the support layer.

[0013] The support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less. A rayon pulp nonwoven fabric is a nonwoven fabric made of composite fibers mixed with rayon fibers and pulp. The maximum load point and elongation at the breaking point refer to the measured values ​​when a strip-shaped test piece measuring 100 mm in length and 20 mm in width is fixed to a tensile testing machine with a chuck distance of 60 mm and measured at a tensile speed of 300 mm [mm / min]. More specifically, these refer to the measured values ​​when measured using the apparatus and conditions described in the examples. Preferably, the rayon pulp nonwoven fabric has a maximum load point of 8 N or more and 30 N or less and an elongation at the breaking point of 30% GL or more and 40% GL or less, and more preferably, the maximum load point of 9 N or more and 27 N or less and an elongation at the breaking point of 31% GL or more and 36% GL or less. The %GL of elongation at the fracture point represents the percentage of the gauge length, i.e., the distance between gauge points.

[0014] The thickness of the rayon pulp nonwoven fabric can be 0.1 mm to 1 mm, and may also be 0.3 mm to 0.7 mm or 0.4 mm to 0.6 mm.

[0015] The basis weight of the rayon pulp nonwoven fabric is 20 g / m². ２ ~100g / m ２ It can be done as 30 g / m ２ ~90g / m ２ or 40 g / m ２ ~80g / m ２ That's fine.

[0016] The lower limit of the density of rayon pulp nonwoven fabric is 0.05 g / cm³. ３The above may also be good, 0.12 g / cm ３ The above may also be good, 0.14 g / cm ３ The above may also be good. On the other hand, the upper limit value of the density of the rayon pulp non-woven fabric may be 0.50 g / cm ３ or less, may be 0.30 g / cm ３ or less, may be 0.20 g / cm ３ or less. The density of the rayon pulp non-woven fabric may be 0.05 g / cm ３ to 0.50 g / cm ３ or may be 0.12 g / cm ３ to 0.30 g / cm ３ or may be 0.14 g / cm ３ to 0.20 g / cm ３ or may be good. By setting the density within such a range, the maximum load point and the elongation at break point can be within the above range.

[0017] As for the weight ratio of rayon to pulp in the rayon pulp non-woven fabric, the strength of the support tends to improve as the weight ratio of pulp increases, that is, the maximum load point tends to increase. On the other hand, as the weight ratio of rayon increases, the strength of the support tends to decrease, that is, the maximum load point tends to decrease. <00000​​​​​​​​​The polyacrylic acid neutralized product may be a fully neutralized polyacrylic acid, a partially neutralized polyacrylic acid, or a mixture thereof. Examples of polyacrylic acid neutralized products include polyacrylate salts, such as sodium salts, potassium salts, calcium salts, and ammonium salts. A partially neutralized polyacrylic acid product has structural units derived from acrylic acid and structural units derived from acrylate salts in any proportion within a single polymer chain. It is preferable to use a partially neutralized polyacrylic acid product in which 50 mol% of the carboxyl groups in a single polymer chain are neutralized, or 35 mol% are neutralized, or both. The content of the polyacrylic acid neutralized product in the adhesive layer can be 2% to 15% by mass, 3% to 10% by mass, or 3% to 5% by mass, based on the total mass of the adhesive layer.

[0022] The methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is an emulsion (aqueous emulsion) in which the methyl acrylate / 2-ethylhexyl acrylate copolymer resin is dispersed in water. The content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin in the emulsion can be 55% to 65% by mass based on the total mass of the emulsion. The emulsion may also contain an emulsifier, such as polyoxyethylene nonylphenyl ether. The content of the emulsifier can be 1% to 5% by mass based on the total mass of the emulsion. The content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion in the adhesive layer is 1.5% to 15% by mass (corresponding to 0.825% to 9.75% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin) based on the total mass of the adhesive layer, preferably 2% to 14% by mass (corresponding to 1.1% to 9.1% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin), and more preferably 3% to 13% by mass (corresponding to 1.65% to 8.45% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin). Examples of commercially available methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsions include Nikazol TS-620 (trade name, manufactured by Nippon Carbide Industries, Ltd.) and BPW HW-2 (trade name, manufactured by Toyo Chem Co., Ltd.).

[0023] The adhesive layer may also contain other components such as water-soluble polymers (excluding polyacrylic acid neutralized products; the same applies hereinafter), cooling agents, solubilizers, crosslinking agents, fillers, humectants, stabilizers, preservatives, chelating agents, colorants, fragrances, pH adjusters, etc.

[0024] The water-soluble polymer is not particularly limited as long as it can retain moisture in the adhesive layer, and those generally known to those skilled in the art can be used. Examples of water-soluble polymers include gelatin, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, hydroxypropyl cellulose, sodium carboxymethylcellulose (carmellose sodium), methylcellulose, and carrageenan. The polyvinyl alcohol may be fully saponified, intermediately saponified, partially saponified, or low-saponified, with intermediate or partially saponified being preferred, and partially saponified being more preferred. The water-soluble polymer may be used alone or in combination of two or more. It is preferable to include at least one selected from the group consisting of gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol as the water-soluble polymer, and it is more preferable to include gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol. If the adhesive layer contains a water-soluble polymer, its content may be 5% to 15% by mass, or 7% to 12% by mass or 8% to 10% by mass, based on the total mass of the adhesive layer.

[0025] Examples of cooling agents include l-menthol, thymol, l-isopulegol, and peppermint oil. Cooling agents may be used individually or in combination of two or more. If the adhesive layer contains a cooling agent, its content may be 0.5% to 1.5% by mass, based on the total mass of the adhesive layer.

[0026] The solubilizer is not particularly limited as long as it can dissolve the drug, and examples include crotamiton; N-methylpyrrolidone; polyalkylene glycols such as polyethylene glycol (PEG) and polybutylene glycol; oxyalkylene fatty acid esters such as polyethylene glycol monostearate; polyoxyalkylene sorbitan fatty acid esters such as polysorbate 80; sorbitan fatty acid esters such as sorbitan monooleate; and surfactants such as polyoxyethylene hydrogenated castor oil. These solubilizers may be used individually or in combination of two or more. If the adhesive layer contains a solubilizer, its content may be 0.1% to 5% by mass, 0.5% to 3% by mass, or 1% to 3% by mass, based on the total mass of the adhesive layer.

[0027] The crosslinking agent is a component used to adjust the progress of the crosslinking reaction between polyacrylic acid neutralized products and the crosslinking reaction between polyacrylic acid neutralized products and optionally added polyacrylic acid. Crosslinking agents commonly used in adhesive sheets can be used. Examples of crosslinking agents include aluminum compounds (magnesium aluminometasilicate, potassium aluminum sulfate (alum), etc.). If the adhesive layer contains a crosslinking agent, its content can be 0.05% to 1% by mass, 0.1% to 0.7% by mass, or 0.2% to 0.5% by mass, based on the total mass of the adhesive layer.

[0028] Examples of fillers include inorganic fillers such as anhydrous silicic acid, titanium dioxide, synthetic aluminum silicate, kaolin, talc, bentonite, and magnesium aluminometasilicate, and may be one of these or a combination of two or more. If the adhesive layer contains a filler, its content may be 0.1% to 1.5% by mass, based on the total mass of the adhesive layer, and may be 0.2% to 1% by mass or 0.3% to 0.7% by mass.

[0029] The humectant is not particularly limited as long as it can suppress the evaporation of moisture from the adhesive layer over time. Examples of the humectant include polyhydric alcohols such as glycerin, sorbitol, ethylene glycol, 1,4 - butanediol, and polyethylene glycol. These humectants may be used alone or in combination of two or more. It is preferable to contain at least one selected from the group consisting of glycerin and sorbitol as the humectant, and more preferably to contain glycerin and sorbitol. When the adhesive layer contains a humectant, the content thereof can be 15% by mass to 45% by mass based on the total mass of the adhesive layer, and may be 20% by mass to 40% by mass or 20% by mass to 30% by mass.

[0030] Examples of the stabilizer include oxybenzone, dibutylhydroxytoluene (BHT), sodium edetate, UV absorbers (e.g., dibenzoylmethane derivatives), and the like. When the adhesive layer contains a stabilizer, the content thereof can be 0.05% by mass to 1% by mass based on the total mass of the adhesive layer, and may be 0.1% by mass to 0.6% by mass or 0.2% by mass to 0.6% by mass.

[0031] Examples of the preservative include methyl paraben, ethyl paraben, propyl paraben, butyl paraben, 1,2 - pentanediol, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, 4 - isopropyl - 3 - methylphenol, 2 - isopropyl - 5 - methylphenol, phenol, hinokitiol, cresol, 2,4,4'-trichloro - 2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, chlorobutanol, benzalkonium chloride, and benzethonium chloride. These preservatives may be used alone or in combination of two or more. When the adhesive layer contains a preservative, the content thereof can be 0.01% by mass to 1% by mass based on the total mass of the adhesive layer, and may be 0.05% by mass to 0.5% by mass or 0.1% by mass to 0.2% by mass.

[0032] Chelating agents include, for example, edetic acid (also known as ethylenediaminetetraacetic acid, EDTA) or its salts, ascorbic acid, pyrophosphates, hexametaphosphates, gluconates, and the like. These chelating agents may be used alone or in combination of two or more. More specifically, examples of edetates include sodium edetate. When the adhesive layer contains a chelating agent, the content thereof can be 0.05% by mass to 1% by mass based on the total mass of the adhesive layer, and may be 0.1% by mass to 0.6% by mass or 0.2% by mass to 0.6% by mass.

[0033] The total mass of the adhesive layer is 200 g / m ２ to 1000 g / m ２ and can be, and may be 400 g / m ２ to 1000 g / m ２ or may be 400 g / m ２ to 650 g / m ２ and may be. <U+ <U+

[0034] The adhesive layer may further contain a drug. In this specification, an adhesive sheet in which the adhesive layer contains a drug is particularly referred to as a patch.

[0035] The drugs are not particularly limited as long as they are absorbed through the skin. Examples of drugs include nonsteroidal anti-inflammatory drugs or their esters such as indomethacin, felbinac, flurbiprofen, diclofenac, diclofenac sodium, methyl salicylate, glycol salicylate, and ketoprofen; antihistamines such as diphenhydramine; analgesics such as aspirin, acetaminophen, ibuprofen, and loxoprofen sodium; local anesthetics such as lidocaine; muscle relaxants such as succinylcholine chloride; antifungal agents such as clotrimazole; antihypertensive agents such as clonidine; vasodilators such as nitroglycerin and isosorbide dinitrate; vitamins such as vitamin A, vitamin E (tocopherol), tocopherol acetate, vitamin K, octotiamine, and riboflavin butyrate; prostaglandins; scopolamine, fentanyl, capsicum extract, l-menthol, dl-camphor, and nonyl vanillylamide. Some drugs have two optical isomers, R- and S-isomers. The drug used in this embodiment may be either one optical isomer or a mixture of the two optical isomers in any proportion. The drug may also be in the form of a pharmaceutically acceptable salt. Examples of pharmaceutically acceptable salts include inorganic base salts such as sodium salts, potassium salts, and calcium salts; organic base salts such as amine salts such as monoethanolamine and diethanolamine; inorganic acid salts such as hydrochloride, nitrate, and phosphate; and organic acid salts such as acetate, lactate, benzenesulfonate, and citrate.

[0036] The amount of drug contained in the adhesive layer should be sufficient to allow the drug to exert its therapeutic effect, and this amount varies depending on the type of drug. For example, based on the total mass of the adhesive layer, the amount of glycol salicylate can be 1% to 3% by mass, and the amount of l-menthol can be 0.5% to 1.5% by mass.

[0037] The poultice contains an adhesive layer comprising a drug, water, glycerin, D-sorbitol, polyacrylic acid neutralized, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, gelatin, polyacrylic acid, partially saponified polyvinyl alcohol, sodium edetate, magnesium aluminometasilicate, and l-menthol. Based on the total mass of the adhesive layer, the drug is 0.3% to 2% by mass, water is 40% to 55% by mass, glycerin is 18% to 22% by mass, and D-sorbitol is 3% to 7% by mass. Preferably, the polyacrylic acid neutralized product is 3% to 5% by mass, the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 3% to 13% by mass, the gelatin is 1% to 5% by mass, the polyacrylic acid is 1% to 5% by mass, the partially saponified polyvinyl alcohol is 1% to 5% by mass, the sodium edetate is 0.2% to 0.6% by mass, the magnesium aluminometasilicate is 0.2% to 0.5% by mass, and the l-menthol is 0.5% to 1.5% by mass.

[0038] The application sites for adhesive sheets and poultices are not particularly limited, but examples include the neck, shoulders, upper arms, forearms, fingers, or wrists. Because the adhesive layer is less likely to peel off the skin or support layer even when wrapped around fingers or wrists, they are particularly suitable for use on fingers or wrists. In particular, when used on fingers, adhesive sheets and poultices longer than the circumference of the finger may be wrapped around the finger, and the adhesive layer may overlap the support layer attached to the skin. Even in such cases, the adhesion of the overlapping portion is sufficient, so it will not peel off even after being attached for a long time, making it particularly suitable for use on fingers.

[0039] Adhesive sheets and poultices can be manufactured, for example, by mixing water, polyacrylic acid neutralized, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (in the case of poultices, in addition to these, a drug is also included), and optionally the above-mentioned optional components to obtain an adhesive composition, uniformly spreading this adhesive composition onto a release liner, and laminating a support layer thereon. Alternatively, adhesive sheets and poultices may be manufactured by uniformly spreading the adhesive composition onto a support layer and laminating a release liner thereon.

[0040] Adhesive compositions were prepared by mixing the components shown in the examples and comparative examples in Tables 1, 3, and 5 below (the numerical values ​​for each component in the table represent mass %). Then, the resulting adhesive composition was applied to an adhesive layer mass of 500 g / m² per unit area. ２ To achieve this, the material is uniformly spread on a release liner (polypropylene film), and a nonwoven fabric support layer is laminated on top of it, for a total length of 35 cm. ２ (7cm x 5cm; for fingers) or 70cm ２ The poultices were obtained by cutting the material to the dimensions of (14 cm x 5 cm; for the wrist). The methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion used was Nikazole TS-620 (trade name, manufactured by Nippon Carbide Industries, Ltd., methyl acrylate / 2-ethylhexyl acrylate copolymer content: 58% by mass based on the total mass of the emulsion), the aminoalkyl methacrylate copolymer E used was Eudragit EPO (trade name, manufactured by Rohm Co., Ltd.), and the butyl methacrylate / methyl methacrylate copolymer used was Plastoid B (trade name, manufactured by Rohm Co., Ltd.). In addition, the concentrated glycerin and D-sorbitol solution used were those listed in the Japanese Pharmacopoeia (18th edition of the Japanese Pharmacopoeia).

[0041] Each poultice was applied to the fingers (middle or ring finger) or wrists of eight subjects, and adhesion, stickiness, residue, pain upon removal, leakage, and liner removal were evaluated using the following methods. The evaluation results are summarized in Tables 2, 4, and 6.

[0042] Evaluation when applied to a finger <Adhesion> The release liner was peeled off the poultice and applied to the subject's finger (middle or ring finger). Immediately after bending and straightening the finger 40 times and after predetermined time intervals (8, 16, and 24 hours), the adhesion of the adhesive layer to the skin and the adhesion of the overlapping portion of the adhesive layer and the support layer were scored according to the following criteria. The average score of the subjects was used as the evaluation result, and a score (average value) of 3.5 or higher (adhesion of the adhesive layer to the skin) and 4.5 or higher (adhesion of the overlapping portion of the adhesive layer and support layer) were judged as acceptable. 6: No peeling 5: Peeling at the edge (peeling of less than 1 / 4 of the application surface) 4: Peeling of 1 / 4 to less than 1 / 3 of the application surface 3: Peeling of 1 / 3 to less than 1 / 2 of the application surface 2: Peeling of 1 / 2 or more of the application surface 1: Detached

[0043] <Stickyness> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the degree of stickiness of the skin where the adhesive was applied was scored according to the following criteria. The average score of the subjects was used as the evaluation result, and a score (average) of 3.0 or higher was judged to be acceptable. 4: Not sticky 3: Not very sticky 2: Slightly sticky (no problem for use) 1: Sticky (problem for use)

[0044] <Ointment Residue> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the degree to which the adhesive layer remained on the skin where the adhesive had been applied was scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 3.0 or higher was judged to be acceptable. 4: No adhesive residue 3: Residue that is not noticeable (residue on one or more but less than two sides of the adhesive layer) 2: Residue on two or more but less than four sides of the adhesive layer 1: Residue on all four sides of the adhesive layer or inside the application surface

[0045] <Pain upon removal> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the pain experienced when removing the poultice from the skin was scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 3.0 or higher was considered acceptable. 4: No pain 3: Not noticeable (no problem for use) 2: Slightly painful 1: Painful

[0046] <Leakage> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the area of ​​the adhesive layer that had seeped onto the support layer of the poultice after it had been removed from the skin was measured and scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 4.0 or higher was judged to be acceptable. 5: No leakage 4: Slight leakage (area: less than 10%) 3: Moderate leakage (area: 10% or more but less than 20%) 2: Significant leakage (area: 20% or more but less than 30%) 1: Quite significant leakage (area: 30% or more)

[0047] <Liner Removal> When removing the removable liner from the poultice, subjects scored the ease of removal according to the following criteria. The average score was used as the evaluation result, and a score (average) of 2.0 to 4.0 was judged as acceptable. 5: Easy 4: Slightly easy 3: Just right 2: Slightly heavy 1: Heavy

[0048] Evaluation when applied to the wrist <Adhesion (wrist)> The release liner was peeled off the poultice and applied to the subject's wrist. The adhesion of the adhesive layer to the skin was scored according to the following criteria immediately after bending and straightening the wrist 40 times and after predetermined time periods (8, 16, and 24 hours). The average score of the subjects was used as the evaluation result, and a score (average) of 3.5 or higher was judged to be acceptable. 6: No peeling 5: Peeling at the edges (peeling of less than 1 / 4 of the application surface) 4: Peeling of 1 / 4 to less than 1 / 3 of the application surface 3: Peeling of 1 / 3 to less than 1 / 2 of the application surface 2: Peeling of 1 / 2 or more of the application surface 1: Detached

[0049] Stickiness, plaster residue, pain during removal, leakage, and liner removal were evaluated in the same way as when applied to the finger.

[0050] The maximum load point and elongation at the breaking point of the support were measured using the following method. The support was punched out into strip-shaped test pieces measuring 100 mm in length and 20 mm in width. The testing machine (Tensilon Tensile Tester RTA-100; manufactured by A&D Co., Ltd.) was set to a distance of 60 mm between the chucks and set as the starting point. The upper end of the test piece was clamped in the upper chuck and fixed. The test piece was pulled by hand to the extent that there was no slack, and the lower end was clamped in the lower chuck and fixed. A load was applied at a tensile speed of 300 mm / min until the test piece broke. The strength at the maximum load point (maximum load point) and elongation at the maximum load point (elongation at the breaking point) of the test piece were measured. Three measurements were taken for each test piece, and the average values ​​were taken as the maximum load point and elongation at the breaking point of the support.

[0051]

[0052]

[0053] In Example 1, the poultice, which used a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion as the adhesive base, exhibited sufficient adhesion, whereas in Comparative Examples 1 and 2, which used other acrylic adhesive bases, the adhesion was insufficient.

[0054]

[0055]

[0056] In Examples 1 to 3, the poultices, which contained methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion in the range of 1.5% to 15% by mass, exhibited sufficient adhesion. In contrast, in Comparative Examples 3 to 5, which contained methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion outside this range, problems arose in terms of adhesion, pain upon removal, or stickiness.

[0057]

[0058]

[0059] In Examples 1, 4-6, the poultices, which had a support layer made of rayon pulp nonwoven fabric with a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less, exhibited sufficient adhesion. In contrast, the poultices of Comparative Examples 6 and 7, which had a support layer made of PET nonwoven fabric or rayon nonwoven fabric, and the poultices of Comparative Examples 8 and 9, which had a support layer made of rayon pulp nonwoven fabric with a maximum load point of less than 8 N or an elongation at the breaking point of 40% GL, exhibited insufficient adhesion.

[0060] Furthermore, poultices were prepared in the same manner as in Example 1, except that diclofenac sodium (1.0% by mass), ketoprofen (0.3% by mass), felbinac (0.7% by mass), or flurbiprofen (0.33% by mass) were used instead of glycol salicylate and l-menthol (Examples 7-10, in order). An adhesive sheet was prepared in the same manner as in Example 1, except that glycol salicylate and l-menthol were excluded (Example 11). The poultices of Examples 7-10 and the adhesive sheet of Example 11 were evaluated in the same manner, and all showed good results in all evaluation items.

Claims

1. An adhesive sheet comprising: a support layer; an adhesive layer laminated on the support layer; and a release liner provided on the side of the adhesive layer opposite to the support layer, wherein the adhesive layer contains water, a polyacrylic acid neutralized product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, and the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less.

2. The adhesive sheet according to claim 1, wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and 30 N or less and an elongation at the breaking point of 30% GL or more and 40% GL or less.

3. A poultice comprising a drug further contained in the adhesive layer of the adhesive sheet according to claim 1 or 2.

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