Antibacterial composition

Abstract

According to an embodiment of the present application, an antibacterial composition is provided. The antibacterial composition may comprise rosemary oil, lavender oil and grapefruit oil. According to embodiments of the present application, the antibacterial composition having improved antibacterial efficacy against acne-causing bacteria and the like can be provided.

Description

Antibacterial composition

[0001] This application relates to an antibacterial composition.

[0002] Skin commensal bacteria are microorganisms that normally inhabit the skin, mucous membranes, nasal cavity, oral cavity, pharynx, digestive tract, and genitourinary tract, and play an important role in defense against external pathogens and prevention of infection. For example, skin commensal bacteria secrete glycerin-related substances that give the skin a glossy finish, produce antimicrobial peptides to combat harmful bacteria, and perform overall skin protection functions.

[0003] However, if commensal bacteria on the skin overgrow, it can cause various problems such as acne and damage to the skin barrier. Antimicrobial agents such as salicylic acid have been used to address these issues, but ingredients such as salicylic acid have shown problems such as causing skin irritation, dryness, and allergic reactions.

[0004] Therefore, research and development of antimicrobial compositions based on skin-friendly natural ingredients are necessary to replace conventional antimicrobial agents, such as salicylic acid, while minimizing skin irritation and allergic reactions.

[0005] The purpose of this application is to provide an antimicrobial composition.

[0006] According to an embodiment of the present application, an antimicrobial composition is provided. The antimicrobial composition comprises rosemary oil, lavender oil, and grapefruit oil.

[0007] In addition, the weight ratio of the rosemary oil and the lavender oil may be 1:0.3 to 0.55.

[0008] In addition, the weight ratio of the rosemary oil and the grapefruit oil may be 1:0.45 to 0.78.

[0009] In addition, the weight ratio of the lavender oil and the grapefruit oil may be 1:1.2 to 1.8.

[0010] In addition, the above antibacterial composition can reduce acne bacteria.

[0011] In addition, the inhibition radius (Clear zone) of the above antibacterial composition against Cutibacterium acnes according to the Paper Disk Diffusion Assay may be 45 mm or more.

[0012] In addition, according to an embodiment of the present application, a cosmetic composition comprising the above antibacterial composition is provided.

[0013] In addition, the cosmetic composition may be manufactured as at least one of sun cream, sun stick, sun milk, sun lotion, sun cushion, nourishing cream, essence, ampoule, toner, lotion, soap, cleanser, cleansing cream, cleansing water, lipstick, lip balm, mascara, blush, shading, highlighter, makeup base, foundation, compact, concealer, skin cover, shampoo, rinse, hair conditioner, hair gel, pack, hydrogel slimming patch, mist, and aerosol.

[0014] In addition, according to an embodiment of the present application, a skin external preparation composition comprising the above antibacterial composition is provided.

[0015] According to the embodiments of the present application, an antibacterial composition with enhanced antibacterial efficacy against acne bacteria, etc., can be provided.

[0016] The effects obtainable from the embodiments of the present application are not limited to those mentioned above, and other unmentioned effects will be clearly understood by those skilled in the art to which the present application belongs from the description below.

[0017] A brief description of each drawing is provided to help to better understand the drawings cited in this application.

[0018] FIG. 1 is a diagram showing the results of the evaluation of the clear zone according to the paper disk diffusion assay of the embodiments and comparative examples of the present application.

[0019] The structural or functional descriptions of the embodiments disclosed in this specification are merely illustrative for the purpose of explaining embodiments according to the technical concept of this application. Furthermore, embodiments according to the technical concept of this application may be implemented in various forms other than those disclosed in this specification. Additionally, the technical concept of this application is not to be interpreted as being limited to the embodiments described in this specification.

[0020] Among the physical properties mentioned in this specification, if the measurement temperature affects the property, the property is the one measured at room temperature and pressure unless otherwise specifically stipulated.

[0021] Unless otherwise specifically defined among the physical properties mentioned in this specification, said physical properties may basically follow the SI unit system. For example, weight may be expressed in kg units, and length may be expressed in m units.

[0022] As used herein, the term "room temperature" refers to a natural temperature that is not heated or cooled, and may mean, for example, any temperature within the range of 10°C to 30°C, for example, about 15°C or higher, about 18°C ​​or higher, about 20°C or higher, about 23°C or higher, about 27°C or lower, or 25°C. Unless specifically defined in this specification, the unit of temperature is Celsius (°C).

[0023] The term "relatively high temperature relative to room temperature" as used in this specification refers to a temperature higher than the room temperature, and may mean, for example, any temperature within the range of 30°C to 50°C, for example, about 35°C or higher, about 40°C or higher, or about 45°C or lower.

[0024] Among the physical properties mentioned in this specification, if the measured pressure affects the physical property, unless otherwise specifically defined, the physical property is the property measured at atmospheric pressure. The term atmospheric pressure used in this specification refers to natural pressure that is not pressurized or depressurized, and typically refers to atmospheric pressure within the range of about 700 mmHg to 800 mmHg.

[0025] As used in this specification, the terms a to b refer to a range between a and b, including a and b. For example, including a to b parts by weight is equivalent to including within the range of a to b parts by weight.

[0026] The terms used herein are for describing embodiments and are not intended to limit or / or restrict the present application. Singular expressions include plural expressions unless the context clearly indicates otherwise. Additionally, numbers used herein (e.g., First, Second, etc.) are merely identifiers to distinguish one component from another.

[0027] In this specification, when a part is described as being connected to another part, this includes not only cases where they are directly connected, but also cases where they are indirectly connected with other components in between. Furthermore, when a part is described as including a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0028] Furthermore, in this application, the term "or" is intended to mean an implicit "or" rather than an exclusive "or." That is, unless otherwise specified or evident from the context, "X uses A or B" is intended to mean one of the natural implicit substitutions. In other words, if X uses A; if X uses B; or if X uses both A and B, "X uses A or B" may apply to any of these cases. Additionally, the term "and / or" as used herein should be understood to refer to and include all possible combinations of one or more of the enumerated related configurations.

[0029]

[0030] According to an embodiment of the present application, an antimicrobial composition is provided. The antimicrobial composition may include rosemary oil, lavender oil, and grapefruit oil. By including rosemary oil, lavender oil, and grapefruit oil, which are natural raw materials, the antimicrobial composition can exhibit antimicrobial efficacy while minimizing harm to the human body. In particular, when the antimicrobial composition includes all of rosemary oil, lavender oil, and grapefruit oil, the antimicrobial efficacy may be enhanced compared to when only some of these are included.

[0031] Rosemary oil is extracted from the leaves, branches, and flowers of the rosemary plant and is effective for antioxidant, anti-inflammatory, improved concentration, enhanced memory, and reduction of stress hormones. Lavender oil is extracted from the leaves, stems, and flowers of the lavender plant and is effective for relieving insomnia, antibacterial, anti-inflammatory, alleviating skin inflammation, and promoting wound healing. Grapefruit oil is extracted from the seeds and peel of the grapefruit and is effective for deodorization, antibacterial, antiviral, cleansing the digestive system, lymphatic circulation, strengthening liver function, relieving stress, and alleviating migraines.

[0032] In the examples, the antimicrobial composition may increase the inhibition radius based on disk diffusion analysis against skin commensal bacteria. Additionally, the antimicrobial composition may decrease the minimum inhibition concentration against skin commensal bacteria.

[0033] In the examples, the weight ratio of rosemary oil and lavender oil may be 1:0.3 to 0.55. For example, the weight ratio of rosemary oil and lavender oil may be 1:0.3 or higher, 1:0.35 or higher, 1:0.4 or higher, 1:0.45 or higher, or 1:0.5 or higher. For example, the weight ratio of rosemary oil and lavender oil may be 1:0.55 or lower, 1:0.5 or lower, 1:0.45 or lower, 1:0.4 or lower, or 1:0.35 or lower.

[0034] In the examples, the weight ratio of rosemary oil to grapefruit oil may be 1:0.45 to 0.78. For example, the weight ratio of rosemary oil to grapefruit oil may be 1:0.45 or higher, 1:0.5 or higher, 1:0.55 or higher, 1:0.6 or higher, 1:0.65 or higher, 1:0.7 or higher, or 1:0.75 or higher. For example, the weight ratio of rosemary oil to grapefruit oil may be 1:0.78 or lower, 1:0.75 or lower, 1:0.7 or lower, 1:0.65 or lower, 1:0.6 or lower, 1:0.55 or lower, or 1:0.5 or lower.

[0035] In the examples, the weight ratio of lavender oil to grapefruit oil may be 1:1.2 to 1.8. For example, the weight ratio of lavender oil to grapefruit oil may be 1:1.2 or higher, 1:1.3 or higher, 1:1.4 or higher, 1:1.5 or higher, 1:1.6 or higher, or 1:1.7 or higher. For example, the weight ratio of lavender oil to grapefruit oil may be 1:1.8 or lower, 1:1.7 or lower, 1:1.6 or lower, 1:1.5 or lower, 1:1.4 or lower, or 1:1.3 or lower.

[0036] If at least one of the numerical ranges described in this specification is satisfied, the antibacterial efficacy may be enhanced. For example, if at least one of the numerical ranges described in this specification is satisfied, the inhibition radius according to disk diffusion analysis against skin commensal bacteria may increase and / or the minimum inhibitory concentration against skin commensal bacteria may decrease.

[0037] In the examples, the antimicrobial composition can reduce one or more types of skin commensal bacteria. For example, the antimicrobial composition can reduce acne bacteria. For example, acne bacteria may include Cutibacterium acnes.

[0038] In the examples, the inhibition radius (clear zone) of one or more skin commensal bacteria of the antimicrobial composition according to the Paper Disk Diffusion Assay may be 45 mm or more. For example, skin commensal bacteria may include acne bacteria. For example, skin commensal bacteria may include Cutibacterium acnes. For example, the inhibition radius of one or more skin commensal bacteria of the antimicrobial composition according to the Paper Disk Diffusion Assay may be 45 mm or more, 46 mm or more, 47 mm or more, 48 mm or more, 49 mm or more, 50 mm or more, or 51 mm or more. For example, the inhibition radius of one or more skin commensal bacteria of the antimicrobial composition according to the Paper Disk Diffusion Assay may be 70 mm or less, 65 mm or less, 60 mm or less, or 55 mm or less.

[0039]

[0040] According to an embodiment of the present application, a cosmetic composition is provided. The cosmetic composition may include an antibacterial composition.

[0041] In the examples, the cosmetic composition may further include additives commonly used in the art within a range that does not impair the effects of the examples of the present application. For example, the cosmetic composition may further include thickeners, pH adjusters, surfactants, stabilizers, preservatives, antiseptics, disinfectants, moisturizers, sunscreens, skin conditioning agents, whitening agents, coloring agents, organic pigments, inorganic pigments, fragrances, vitamins, natural colorants, pearls, and other functional ingredients. Here, the functional ingredients may include, for example, wrinkle-improving ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrub ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity-enhancing ingredients, etc. The amount of the above ingredients can be easily selected by a person skilled in the art within a range that does not impair the purpose and effects of the present application.

[0042] In the examples, the cosmetic composition may be provided in formulations commonly manufactured in the art. For example, the cosmetic composition may be formulated into an oil-dispersed formulation in which a powder complex is dispersed in an oil phase, a water-dispersed formulation in which a powder complex is dispersed in an aqueous phase, an emulsion formulation of the type of oil in water (O / W), water in oil (W / O), oil in water in water (W / O / W), and oil in water in oil (O / W / O), a solubilized formulation, etc. However, it is not limited thereto, and the cosmetic composition may also be provided in formulations such as a solution, suspension, emulsion, solid, gel, oil, powder, paste, or foam aerosol.

[0043] In the examples, the cosmetic composition can be manufactured into various products. For example, it can be manufactured into sun care products such as sun cream, sun stick, sun milk, sun lotion, and sun cushion. For example, it can be manufactured into functional cosmetics such as nourishing cream, essence, and ampoule, or into basic cosmetics such as toner and lotion. In addition, it can be manufactured into soap, cleanser, cleansing cream, cleansing water, etc., or into color cosmetics such as lipstick, lip balm, mascara, blush, shading, highlighter, makeup base, foundation, compact powder, concealer, skin cover, etc. Furthermore, it can be manufactured into hair cleansing products such as shampoo, rinse, hair conditioner, hair gel, etc. Additionally, it can be manufactured into products that are attached to the skin, such as packs and hydrogel slimming patches, or products that are sprayed onto the skin, such as mist and aerosol.

[0044] In the examples, the cosmetic composition may be a topical skin composition. For example, the topical skin composition may have a formulation such as a solution, oil, paste, cream, gel, patch, spray, etc.

[0045] In the examples, the skin topical composition may appropriately incorporate ingredients commonly used in skin topical preparations such as cosmetics or pharmaceuticals, for example, aqueous ingredients, oily ingredients, powder ingredients, alcohols, moisturizers, thickeners, sunscreens, whitening agents, preservatives, antioxidants, surfactants, fragrances, colorants, fatty substances, solvents, thickeners, gelling agents, emollients, foaming agents, fragrances, metal ion chelating agents, chelating agents, vitamins, various skin nutrients, or combinations thereof as needed. The amount of the above ingredients can be easily selected by a person skilled in the art within a range that does not impair the purpose and effect of the present application.

[0046]

[0047] According to an embodiment of the present application, a food composition is provided. The food composition may include an antimicrobial composition.

[0048] In the examples, the food composition may further include additives commonly used in the art to the extent that they do not impair the effects of the examples of the present application. For example, the food composition may include proteins, carbohydrates, fats, nutrients, seasonings, flavoring agents, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonating agents, etc. For example, carbohydrates may include monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, sugar alcohols such as xylitol, sorbitol, and erythritol, etc. Additionally, for example, flavoring agents may include natural sweeteners such as taumatin and stevia extract, or synthetic sweeteners such as saccharin and aspartame. The amount of the above ingredients can be easily selected by a person skilled in the art within a range that does not impair the purpose and effect of the present application.

[0049] In the examples, the food composition may be provided in a formulation commonly manufactured in the art. For example, the food composition may be provided in a formulation such as a beverage, pill, granule, tablet, or capsule.

[0050] In the examples, the food composition may be manufactured into various products. For example, the food composition may be manufactured as a health functional food or a health supplement. "Health functional food or health supplement" refers to a food manufactured and processed using raw materials or ingredients having functional properties useful to the human body in accordance with the Health Functional Foods Act, and "functional properties" refers to effects useful for health purposes, such as regulating nutrients or physiological actions regarding the structure and function of the human body. For example, the food composition may be manufactured into various products, such as being added to food materials like beverages, teas, spices, chewing gum, and confectionery, or being encapsulated, powdered, or manufactured as a suspension.

[0051] In the examples, the food composition may further include food additives commonly used in the art. The food additives may include, for example, chemically synthesized compounds such as ketones, glycine, potassium citrate, nicotinic acid, and cinnamon acid; natural additives such as persimmon dye, licorice extract, crystalline cellulose, sorghum dye, and guar gum; and mixed preparations such as L-sodium glutamate preparations, alkaline noodle additives, preservative preparations, and tar dye preparations.

[0052]

[0053] According to an embodiment of the present application, a pharmaceutical composition is provided. The pharmaceutical composition may include an antimicrobial composition.

[0054] In the examples, the pharmaceutical composition comprises the composition and may further comprise a pharmaceutically acceptable carrier. "Pharmaceutically acceptable" means physiologically acceptable and, when administered to humans, does not typically cause allergic reactions or similar reactions such as gastrointestinal disturbances or dizziness. "Pharmaceutically acceptable carriers" include liquid or non-liquid carriers.

[0055] In the examples, pharmaceutically acceptable carriers may include those commonly used in the art. For example, pharmaceutically acceptable carriers may include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil.

[0056] In the examples, the pharmaceutical composition may further include diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, surfactants, and other pharmaceutically acceptable additives.

[0057] In the examples, the pharmaceutical composition may be prepared in formulations commonly manufactured in the art. For example, the pharmaceutical composition may be prepared in the form of a liquid, emulsion, syrup, aerosol, suspension, powder, granule, tablet, capsule, soft capsule, pill, extract, suppository, etc.

[0058] In the examples, the pharmaceutical composition may be administered orally or parenterally (e.g., topically or intravenously, subcutaneously, or intraperitoneally). The term "oral administration" refers to a method of administering a drug to alleviate pathological symptoms by mouth, and the term "parenteral administration" refers to a method of administering subcutaneously, intramuscularly, intravenously, or intraperitoneally using a tube, excluding oral administration.

[0059]

[0060] The present invention will be explained below through manufacturing examples and experimental examples, but the scope of the present invention is not limited by the contents presented below.

[0061]

[0062] Preparation Example

[0063]

[0064] (1) Preparation Example 1: Preparation of Examples 1 to 3

[0065] Examples 1 to 3 were prepared by changing the weight ratio of rosemary oil, lavender oil, and grapefruit oil as described in Table 1, while maintaining the total weight of the rosemary oil, lavender oil, and grapefruit oil included in the antibacterial composition at equal amounts.

[0066]

[0067] Classification Example 1 Example 2 Example 3 Rosemary Oil 5 4 6 Lavender Oil 2 2 2 Grapefruit Oil 3 3 3 Rosemary Oil : Lavender Oil 1 : 0.41 : 0.51 : 0.3 3 Rosemary Oil : Grapefruit Oil 1 : 0.61 : 0.751 : 0.5 Lavender Oil : Grapefruit Oil 1 : 1.51 : 1.51 : 1.5

[0068]

[0069] (2) Preparation Example 2: Preparation of Comparative Examples 1 to 19

[0070] Comparative Examples 1 to 19 were prepared by maintaining the total weight of rosemary oil, lavender oil, grapefruit oil, eucalyptus oil, and bergamot oil included in the antibacterial composition at equal amounts, while changing the weight ratio of rosemary oil, lavender oil, grapefruit oil, eucalyptus oil, and bergamot oil as described in Tables 2 to 4.

[0071]

[0072] Classification Comparison Example 1 Comparison Example 2 Comparison Example 3 Comparison Example 4 Comparison Example 5 Rosemary Oil----2 Lavender Oil10----Grapefruit Oil-10---Eucalyptus Oil--10-1 Bergamot Oil---102

[0073]

[0074] Classification Comparison Example 6 Comparison Example 7 Comparison Example 8 Comparison Example 9 Comparison Example 10 Comparison Example 11 Comparison Example 12 Rosemary Oil -3 7 2 5 5 Lavender Oil 2 2 2 --0.5 Grapefruit Oil 3 3 3 1 3 3 Rosemary Oil : Lavender Oil -1 : 0.6 7 1 : 0.29 --1 : 0.11 : 0.2 Rosemary Oil : Grapefruit Oil -1 : 11 : 0.4 3 1 : 0.5 1 : 0.6 1 : 0.6 1 : 0.6 Lavender Oil : Grapefruit Oil 1 : 1.5 1 : 1.5 1 : 1.5 --1 : 6 1 : 3

[0075]

[0076] Classification Comparison Example 13 Comparison Example 14 Comparison Example 15 Comparison Example 16 Comparison Example 17 Comparison Example 18 Comparison Example 19 Rosemary Oil 5 5 5 5 5 5 Lavender Oil 3 4 2 2 2 2 Grapefruit Oil 3 3 - 1 2 4 Rosemary Oil : Lavender Oil 1 : 0.61 : 0.81 : 0.41 : 0.41 : 0.41 : 0.41 : 0.4 Rosemary Oil : Grapefruit Oil 1 : 0.61 : 0.6 - 1 : 0.21 : 0.41 : 0.81 : 1 Lavender Oil : Grapefruit Oil 1 : 11 : 0.75 - 1 : 0.5 1 : 11 : 21 : 2.5

[0077]

[0078] Experimental Example

[0079]

[0080] (1) Experimental Example 1: Evaluation of Clear Zone based on Paper Disk Diffusion Assay

[0081] The inhibition radius based on disk diffusion analysis for Cutibacterium acnes in Examples 1 to 3 and Comparative Examples 1 to 19 was measured, and the results are shown in Table 5 and Figure 1. In Figure 1, the horizontal axis represents Examples 1 to 3 and Comparative Examples 1 to 19 in order.

[0082] Specifically, after plating Cutibacterium acnes on an agar medium, a paper disk was placed on the medium, and each antimicrobial composition was dispensed onto the paper disk, and the diameter of the inhibition zone where bacterial growth was inhibited was checked.

[0083]

[0084] Distinction Suppression Radius (mm) Example 1 51.9 Example 2 48.9 Example 3 51.0 Comparative Example 1 34.6 Comparative Example 2 31.2 Comparative Example 3 43.2 Comparative Example 4 23.8 Comparative Example 5 24.6 Comparative Example 6 30.6 Comparative Example 7 41.7 Comparative Example 8 30.6 Comparative Example 9 29.2 Comparative Example 10 29.4 Comparative Example 11 28.6 Comparative Example 12 25.1 Comparative Example 13 29.1 Comparative Example 14 29.1 Comparative Example 15 31.0 Comparative Example 16 28.8 Comparative Example 17 37.1 Comparative Example 18 43.8 Comparative Example 19 30.2

[0085]

[0086] As a result of the experiment, in the case of Examples 1 to 3, the inhibition radius against Cutibacterium acnes was measured to be significantly larger compared to Comparative Examples 1 to 19, and it was confirmed that the antibacterial activity was excellent.

[0087]

[0088] (2) Experimental Example 2: Evaluation of Minimum Inhibitory Concentration (MIC test)

[0089] The minimum inhibitory concentrations against Cutibacterium acnes of Examples 1 to 3 and Comparative Examples 1 to 5 were measured, and the results are shown in Table 6.

[0090] Specifically, after dispensing each antimicrobial composition into a liquid medium at different concentrations, Cutibacterium acnes bacterial suspension was inoculated into the liquid medium and cultured to determine the minimum concentration (MIC) at which the bacteria did not grow.

[0091]

[0092] Classification Minimum Inhibitory Concentration (mg / ml) Minimum Inhibitory Concentration (ppm) Example 11 to 21,000 to 2,000 Comparative Example 12 > 2,000 > 2,000 Comparative Example 22 > 2,000 > 2,000 Comparative Example 32 > 2,000 > 2,000 Comparative Example 42 > 2,000 > 2,000 Comparative Example 52 > 2,000 > 2,000

[0093]

[0094] As a result of the experiment, it was confirmed that in the case of Example 1, the minimum inhibitory concentration against Cutibacterium acnes was measured to be lower compared to Comparative Examples 1 to 5.

[0095]

[0096] Foregoing, specific parts of the contents of this application have been described in detail. It will be apparent to those skilled in the art that such specific descriptions are merely preferred embodiments and do not limit the scope of this application. Accordingly, the actual scope of this application is defined by the appended claims and their equivalents.

Claims

1. As an antibacterial composition, An antibacterial composition comprising rosemary oil, lavender oil, and grapefruit oil.

2. In Paragraph 1, An antibacterial composition in which the weight ratio of the rosemary oil and the lavender oil is 1:0.3 to 0.

55.

3. In Paragraph 1, An antibacterial composition in which the weight ratio of the rosemary oil and the grapefruit oil is 1:0.45 to 0.

78.

4. In Paragraph 1, An antibacterial composition in which the weight ratio of the lavender oil and the grapefruit oil is 1:1.2 to 1.

8.

5. In Paragraph 1, The above antibacterial composition is an antibacterial composition that reduces acne bacteria.

6. In Paragraph 1, An antibacterial composition having a clear zone of 45 mm or more against Cutibacterium acnes according to a paper disk diffusion assay.

7. A cosmetic composition comprising an antibacterial composition according to any one of claims 1 to 6.

8. In Paragraph 7, The above cosmetic composition is prepared as at least one of a sun cream, sun stick, sun milk, sun lotion, sun cushion, nourishing cream, essence, ampoule, toner, lotion, soap, cleanser, cleansing cream, cleansing water, lipstick, lip balm, mascara, blush, shading, highlighter, makeup base, foundation, compact powder, concealer, skin cover, shampoo, rinse, hair conditioner, hair gel, pack, hydrogel slimming patch, mist, and aerosol.

9. A skin external preparation composition comprising an antibacterial composition according to any one of claims 1 to 6.

Images