Multi-cartridge dispensing device for personalized oral formulation delivery

Abstract

The present invention relates to a multi-cartridge dispensing device for personalized oral formulation delivery, particularly for gingivitis and related periodontal conditions. The system comprises multiple ingredient cartridges (103, 202), a mixing chamber (105) for automated homogenization, a flexible dispensing nozzle 5 (106) for targeted drug application, and a plunger mechanism (101) for controlled formulation release. The device enables precise mixing of active ingredients such as EDTA, Tranexamic Acid, Minocycline, Diclofenac, and Lignocaine, ensuring accurate dosage customization based on patient-specific treatment needs. A volume adjustment mechanism (107) allows fine-tuned regulation of ingredient 10 concentrations, while a display window (108) provides real-time feedback on ingredient selection and dosage levels. The invention eliminates the need for multiple separate medications, enhances treatment adherence, and improves therapeutic efficacy. Designed for home use and clinical settings, this system provides an advanced and efficient approach to personalized oral healthcare 15 through controlled drug dispensing.

Description

[0001] Title of the Invention

[0002] MULTI-CARTRIDGE DISPENSING DEVICE FOR PERSONALIZED ORAL FORMULATION DELIVERY

[0003] FIELD OF THE INVENTION

[0004] The present invention relates to a multi-cartridge dispensing device for customizable oral formulation delivery, specifically designed for personalized gingivitis treatment.

[0005] More specifically, the invention enables real-time customization of therapeutic formulations by allowing precise dispensing and mixing of multiple active ingredients based on patient-specific treatment requirements.

[0006] BACKGROUND OF THE INVENTION

[0007] Oral healthcare has witnessed significant advancements in recent years, yet the treatment of conditions such as gingivitis remains largely dependent on fixed-dose formulations that fail to account for patient-specific needs. Gingivitis, a prevalent condition affecting a large portion of the global population, requires a multifaceted approach involving anti-inflammatory agents, antimicrobials, chelating compounds, and local anesthetics. However, conventional oral treatment methods rely on pre-mixed solutions that lack flexibility in dosage and ingredient composition. As a result, these formulations do not offer customization based on disease severity, individual response to treatment, or changes in patient condition over time. Despite growing interest in precision medicine, the field of oral drug delivery has been slow to adopt customizable and Al-driven solutions, leading to suboptimal therapeutic outcomes and poor patient adherence.

[0008] One of the fundamental limitations of current treatment methods is the inability to personalize medication formulations. Most oral care products, including gels, rinses, and antibiotic applications, contain predefined concentrations of active agents, designed to treat a broad spectrum of patients without considering individual variations. Patients with mild, moderate, or severe forms of gingivitis areoften prescribed the same standardized formulation, which can result in ineffective treatment for some and overmedication for others. Those with aggressive gingivitis may require higher doses of antimicrobials, whereas those with mild cases may need lower dosages to prevent unnecessary drug exposure. The lack of real-time adaptability in conventional treatments means that patients often continue using the same formulation even if their condition improves or worsens, leading to either prolonged treatment durations or unnecessary exposure to active agents.

[0009] Another major drawback of existing treatment solutions is the absence of real-time adjustments based on patient response. The nature of gingivitis is dynamic, influenced by bacterial activity, immune response, and lifestyle factors. However, current medications are designed to be used over a fixed duration, without the ability to modify their composition in response to ongoing changes in the patient’s condition. This results in either overuse of drugs when symptoms subside earlier than expected or ineffective treatment when a formulation fails to provide adequate therapeutic action. Patients often need to switch between multiple medications to address different aspects of gingivitis, such as inflammation, pain, bleeding, and bacterial infection, creating complex treatment regimens that lead to poor compliance and increased treatment costs.

[0010] Furthermore, the administration of multiple separate medications poses significant challenges in treatment adherence. Gingivitis treatment often requires the use of anti-inflammatory agents (e.g., Diclofenac), antimicrobial agents (e.g., Minocycline), chelating agents (e.g., EDTA), hemostatic agents (e.g., Tranexamic Acid), and local anesthetics (e.g., Lignocaine). Currently, patients must use these medications separately or rely on combination products with fixed ratios, neither of which allows for fine-tuned adjustments based on individual needs. Patients required to apply multiple medications at different times of the day may struggle with complex dosage schedules, leading to reduced adherence and compromised treatment efficacy. A simplified, all-in-one solution that allows for customized dosing and ingredient selection would significantly improve patient compliance and therapeutic effectiveness.Manual mixing of medications is sometimes attempted in clinical or home settings, but this approach introduces several risks. Without a precise mixing mechanism, patients and healthcare providers may miscalculate ingredient proportions, leading to under- or overdosing. Additionally, certain active agents can be chemically incompatible when mixed manually, potentially resulting in reduced stability or adverse drug interactions. The lack of precision in manual drug preparation makes it impractical and unreliable, further emphasizing the need for an automated system that ensures accurate dosing and homogeneous mixing of therapeutic agents before application.

[0011] Another significant challenge associated with pre-mixed formulations is stability and shelf-life concerns. Many active pharmaceutical ingredients degrade overtime when stored in liquid or gel form, leading to loss of potency. For example, antibiotics and chelating agents may lose effectiveness when exposed to air, moisture, or light, reducing their ability to combat gingival infections and plaque formation. Local anesthetics and anti-inflammatory agents may also degrade, resulting in diminished pain relief and anti-inflammatory action. To maintain optimal drug potency, active agents should ideally be stored separately and mixed only at the time of application, preventing degradation and ensuring maximum therapeutic efficacy.

[0012] Given these limitations, there is a clear need for a dispensing system that allows for real-time customization of oral formulations. The present invention addresses the challenges posed by the existing state of the art and describes an artificial intelligence driven multi-cartridge dispensing device for personalized oral formulation delivery.

[0013] OBJECTS OF THE INVENTION

[0014] The primary object of the invention is to provide a multi -cartridge dispensing system that allows for separate storage and controlled dispensing of multiple active ingredients, ensuring precise formulation and improved drug stability.A further objective of the invention is to enable real-time customization of oral formulations by allowing precise adjustment of ingredient concentrations and combinations based on patient-specific treatment requirements.

[0015] Another objective of the invention is to improve treatment precision and efficacy by offering fine-tuned control over dosage levels, ensuring optimal therapeutic effectiveness while minimizing drug wastage.

[0016] A further objective of the invention is to eliminate the inefficiencies of fixed-dose formulations by providing a single dispensing device capable of delivering a wide range of therapeutic combinations tailored to individual patient conditions.

[0017] An additional objective of the invention is to enhance user control and convenience through a volume adjustment mechanism and a display window that provides realtime feedback on ingredient selection and dosage levels.

[0018] BRIEF DESCRIPTION OF DRAWINGS

[0019] The accompanying drawings constitute a part of this specification and illustrate one or more embodiments of the invention. Preferred embodiments of the invention are described in the following with reference to the drawings, which are for the purpose of illustrating the present preferred embodiments of the invention and not for the purpose of limiting the same.

[0020] For simplicity and clarity of illustration, the drawing figures illustrate the general manner of construction, and descriptions and details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the invention. Additionally, elements in the drawing figures are not necessarily drawn to scale. For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help improve understanding of embodiments of the present invention. The same reference numerals in different figures denotes the same elements.

[0021] In the drawings:

[0022] Figure 1 illustrates a customizable oral formulation dispensing device (100) designed for gingivitis treatment. The system features a multi -cartridge mechanism(103, 202) that allows for precise and patient-specific mixing of active ingredients. It includes individual ingredient cartridges (103, 202) containing key treatment agents such as EDTA (for plaque removal), Tranexamic Acid (for bleeding control), Minocycline (for antimicrobial action), Carbopol (as a base for formulation stability), Lignocaine (for local anesthetic effect), and Diclofenac (for antiinflammatory relief). These cartridges are systematically aligned within the cartridge compartment (104) to dispense precise amounts into the mixing area (105), where the selected ingredients are homogenized to create a personalized formulation.

[0023] A plunger mechanism (101) facilitates controlled dispensing, ensuring accurate dosing. The volume adjustment knob (107) allows users to regulate the quantity of each ingredient, enabling real-time formulation customization. A display window (108) provides visual feedback on ingredient selection, dosage, and dispensing status, enhancing precision and ease of use. Once the formulation is prepared, it is dispensed through a flexible nozzle (106), allowing for targeted application to the gingival region, ensuring maximum therapeutic effectiveness. The secure cartridge holder (201) with a locking mechanism ensures proper alignment and prevents leakage or contamination of active ingredients.

[0024] Figure 2 illustrates a detailed view of the volume adjustment and cartridge system of the customizable oral formulation dispensing device (200). It highlights key components essential for precise dosing and controlled dispensing of the treatment formulation.

[0025] The volume adjustment knob (107) allows for fine-tuned control over the amount of each active ingredient dispensed, ensuring accurate formulation customization based on patient-specific requirements. The display window (108) provides realtime feedback on ingredient selection and dosage levels, enhancing precision and ease of monitoring.

[0026] The cartridge system (103, 202), securely held in place within the cartridge holder (201), is designed to store and dispense specific active agents such as Diclofenac, EDTA, Minocycline, Tranexamic Acid, and Lignocaine. Each cartridge is markedwith measurement indicators (203) (e.g., 1.5 ml, 1.0 ml) to allow precise volume regulation. The precision-controlled dispensing valve (206) ensures accurate ingredient release, preventing over-dispensing or leakage, thereby maintaining formulation stability and consistency.

[0027] The combination of precise volume control, secure cartridge locking, and a controlled dispensing mechanism ensures optimal customization of gingivitis treatment, making the device an effective and user-friendly oral healthcare solution. This system ensures controlled mixing of ingredients, improving treatment efficacy by delivering personalized oral formulations.

[0028] By integrating precise volume control, real-time monitoring, and a secure cartridgebased dispensing mechanism, this device enables tailored gingivitis treatment, significantly enhancing therapeutic effectiveness and patient compliance.

[0029] SUMMARY OF THE INVENTION

[0030] Embodiments of the present disclosure present technological improvements as a solution to one or more of the above-mentioned technical problems recognized by the inventor in existing techniques.

[0031] The present invention relates to a multi-cartridge dispensing device for personalized oral formulation delivery, specifically designed for the treatment of gingivitis and other periodontal conditions. Unlike conventional fixed-dose treatments, this device enables precise and customizable dispensing of multiple active pharmaceutical agents in controlled proportions. The system comprises multiple ingredient cartridges, an automated mixing chamber, a plunger mechanism for controlled dispensing, a flexible nozzle for targeted drug application, and a volume adjustment mechanism for real-time dosage customization.

[0032] Each ingredient cartridge stores a distinct active agent such as EDTA, Tranexamic Acid, Minocycline, Diclofenac, and Lignocaine. The cartridges are securely housed in a compartment, ensuring proper alignment and contamination-free dispensing. A precision-controlled dispensing mechanism releases measured volumes of selected ingredients into a mixing chamber, where they are homogenized before application.A display window provides real-time feedback on ingredient selection and dosage levels, allowing for enhanced control and accuracy.

[0033] The device supports interchangeable cartridges, allowing healthcare providers or patients to tailor treatment formulations based on specific medical needs. The volume adjustment knob enables fine-tuned modification of ingredient concentrations, ensuring optimal therapeutic effectiveness while minimizing drug wastage. The flexible dispensing nozzle is designed for direct application to affected gingival areas, ensuring localized treatment with minimal systemic absorption.

[0034] This invention eliminates the need for multiple separate medications, simplifying treatment regimens and improving patient adherence. The system is suitable for use in both home settings and professional dental clinics, providing a practical and efficient solution for personalized oral healthcare. By enabling precise formulation customization and controlled dispensing, this invention enhances therapeutic efficacy, ensures consistent treatment outcomes, and advances oral healthcare technology.

[0035] The objects and the advantages of the invention are achieved by the process elaborated in the present disclosure.

[0036] DETAILED DESCRIPTION OF THE INVENTION

[0037] The following detailed description illustrates embodiments of the present disclosure and ways in which the disclosed embodiments can be implemented. Although some modes of carrying out the present disclosure have been disclosed, those skilled in the art would recognize that other embodiments for carrying out or practicing the present disclosure are also possible.

[0038] The present invention is illustrated with reference to the accompanying drawings, throughout which reference numbers indicate corresponding parts in the various figures. These reference numbers are shown in brackets in the following description.The present invention relates to a multi-cartridge dispensing device for personalized oral formulation delivery, used in treating gingivitis and other oral health conditions. Unlike conventional treatment methods that rely on fixed-dose formulations, this invention provides a real-time, customizable solution that adjusts drug composition and dosage based on patient-specific factors, clinical history, and real-time treatment response. The system combines a multi -cartridge dispensing mechanism (103, 202), an automated mixing chamber (105), and a precision-controlled nozzle (106) to ensure highly targeted and effective drug delivery. The core principle behind this invention is real-time customization of therapeutic formulations. The system consists of multiple ingredient cartridges (103, 202), each containing a specific active agent such as EDTA (for plaque removal), Tranexamic Acid (for bleeding control), Minocycline (for antimicrobial action), Diclofenac (for inflammation reduction), Lignocaine (for pain relief), and Carbopol (for formulation stability). These cartridges are securely housed in a cartridge compartment (104) that allows precise ingredient dispensing as per the treatment plan. The selected ingredients are then directed into a mixing chamber (105), where they are thoroughly blended to achieve a homogeneous formulation before application.

[0039] The invention comprises several key components that work together to provide precision drug dispensing and real-time customization.

[0040] According to an embodiment of the present invention, the device is equipped with a plunger mechanism (101) that facilitates controlled dispensing, ensuring accurate dosing. A volume adjustment knob (107) allows users to regulate the quantity of each ingredient, enabling real-time formulation customization. Additionally, a display window (108) provides real-time feedback on ingredient selection, dispensing volumes, and dosage levels. The final formulation is dispensed through a flexible nozzle (106), allowing for precise application to the affected gingival areas. This ensures that the active agents are delivered directly to inflamed or infected tissues, maximizing therapeutic efficacy while minimizing systemic absorption and side effects.The plunger (101) is precision-calibrated, ensuring accurate dosage delivery and preventing accidental overdosing. Upon activation, the plunger (101) exerts controlled pressure on the mixing chamber (105), enabling the smooth and metered flow of the final formulation through the flexible nozzle (106). The plunger actuation force is adjustable, allowing users to regulate the dispensing speed and volume as per treatment requirements. Additionally, the plunger mechanism (101) incorporates a spring-loaded return function, ensuring that once the required volume is dispensed, the system resets to its initial position, preventing unnecessary leakage or ingredient wastage. The ergonomic design of the plunger allows for single-hand operation, enhancing user convenience during application.

[0041] According to an embodiment of the present invention, the dispensing mechanism is configured to release measured volumes of selected ingredients through a mechanically controlled actuation system. This mechanism ensures precise and consistent dispensing of active agents from the ingredient cartridges (103, 202) into the mixing chamber (105). The dispensing system operates through a plunger-activated release mechanism (101), which enables controlled and incremental discharge of liquid formulations.

[0042] The mechanically controlled actuation system consists of precision dispensing valves (206) and a calibrated plunger assembly (101) that work in coordination to regulate the flow of each ingredient based on predefined dosage levels. The user can manually adjust the volume using the volume adjustment knob (107), ensuring that each formulation is tailored to the patient’s specific needs. Additionally, the actuation system includes a backflow prevention feature, ensuring that no crosscontamination occurs between the stored ingredients and the mixed formulation. Furthermore, the dispensing mechanism (103, 206, 202) is designed to work seamlessly with interchangeable cartridges (202), allowing for easy replacement and refilling while maintaining formulation stability. This controlled release technology not only enhances accuracy but also minimizes wastage and ensures that each ingredient is dispensed in a precise, metered quantity, optimizing therapeutic outcomes.According to an embodiment of the present invention, the device includes multiple cartridges (103, 202), each containing a separate active ingredient essential for gingivitis treatment. These cartridges are systematically aligned within a secure cartridge holder (201) to ensure controlled and accurate dispensing. They are individually sealed to maintain ingredient stability and prevent contamination. Each cartridge features a precision dispensing valve (206), which allows for accurate release of measured volumes into the mixing chamber (105). The cartridges are marked with measurement indicators (203) (e.g., 1.5 ml, 1.0 ml) to enable precise volume regulation. Additionally, the device supports interchangeable cartridges (202), enabling easy refilling and customization based on patient needs. The cartridge holder (201) further includes a locking mechanism to maintain proper alignment, prevent leakage, and ensure contamination-free storage of active ingredients.

[0043] According to an embodiment of the present invention, once the selected ingredients are dispensed, they are directed into a mixing chamber (105), where they are homogenized. This ensures proper blending of ingredients in precise ratios. The mixing chamber (105) is designed with anti -adherence coatings and a contamination-resistant internal structure to prevent cross-contamination and ensure that each formulation is prepared freshly before application. This controlled mixing process enhances treatment efficacy by delivering a well-balanced and optimized formulation.

[0044] According to an embodiment of the present invention, the device features a volume adjustment knob (107) that allows for fine-tuned control over the amount of each active ingredient dispensed, ensuring accurate formulation customization based on patient-specific requirements. The volume adjustment mechanism (107) is designed to provide precise control over the concentration of individual ingredients dispensed from the cartridges. This mechanism consists of a calibrated rotary dial, allowing real-time manual adjustment of ingredient volumes before they are mixed and dispensed. A display window (108) provides a visual indication of the selected volume, ensuring accuracy and repeatability.According to an embodiment of the present invention, a flexible, ergonomic nozzle (106) ensures precise application of the formulation to affected gingival areas. The nozzle is composed of medical-grade silicone, polyethylene (PE), or polypropylene (PP) for standard use, and biocompatible thermoplastic elastomers (TPE) or polytetrafluoroethylene (PTFE) for specialized medical applications. The nozzle (106) is designed to ensure painless application while maximizing therapeutic absorption at the site of infection or inflammation.

[0045] According to an embodiment of the present invention, the flexible dispensing nozzle (106) is interchangeable, allowing the selection of different nozzle types based on formulation viscosity, flow characteristics, and targeted application requirements. The nozzle system includes spray, jet, and drip nozzles, each designed to optimize drug delivery efficiency for various treatment scenarios. The spray nozzle ensures even distribution of low-viscosity formulations over a broader gingival surface. The jet nozzle delivers a highly concentrated and directed stream, ideal for localized treatment of inflamed or infected gingival pockets. The drip nozzle provides controlled droplet-based dispensing, ensuring precise placement of higher- viscosity formulations or gel-based treatments. The interchangeable nozzle system enhances the device’s versatility and adaptability, allowing users to customize drug application based on the specific treatment needs of each patient. The present invention can be implemented in various embodiments, depending on the intended use and deployment setting.

[0046] According to an embodiment, the device can be used at home, allowing patients to self-administer personalized gingivitis treatment. The device is compact, battery-operated, and portable, making it convenient for daily use.

[0047] According to further embodiment of the invention, the said device can be configured for paediatric patients by adjusting ingredient concentrations and dosage levels to ensure safe and effective treatment. Similarly, for elderly patients, the device can account for comorbid conditions such as diabetes, cardiovascular diseases, and medication interactions, ensuring a personalized yet safe therapeutic approach.According to another embodiment, the device can be used in dental clinics, where healthcare providers can prepare customized formulations in real time for their patients.

[0048] The multi-cartridge dispensing device offers several advantages over conventional oral healthcare treatments:

[0049] ■ Real-Time Customization: The dispensing mechanism ensures personalized drug formulations based on patient-specific data.

[0050] ■ Precision Drug Delivery: The multi-cartridge mechanism eliminates dosing errors, improving therapeutic effectiveness.

[0051] ■ Improved Drug Stability: Ingredients are stored separately and mixed only before application, preventing degradation and loss of potency.

[0052] ■ Simplified Treatment Regimen: Patients no longer need to use multiple separate medications, improving adherence and convenience.

[0053] ■ Continuous Monitoring and Adjustments: The system tracks treatment progress and allows dynamic refinements.

[0054] ■ Broader Healthcare Applications: The device can be adapted for various oral healthcare needs, including periodontal disease management, wound healing, and pain relief formulations.

[0055] The multi-cartridge dispensing device represents a groundbreaking innovation in personalized oral healthcare. By combining a precision drug dispensing mechanism and customizable formulation adjustments, the invention ensures highly effective, patient-specific treatment for gingivitis and related conditions. Whether used in home settings, dental clinics, or remote monitoring devices, this invention enhances therapeutic efficacy, improves patient compliance, and significantly advances oral healthcare technology.

[0056] These embodiments are provided to demonstrate the various aspects and features of the multi -cartridge dispensing device for personalized oral formulation delivery. The invention is not limited to these specific embodiments and can be implemented in different configurations and variations without departing from the scope of the invention as defined in the claims.

Claims

CLAIMS:We Claim:

1. A multi -cartridge dispensing device for personalized oral formulation delivery, the said multi -cartridge dispensing device comprising:a set of ingredient cartridges (103, 202), each configured to store a distinct active pharmaceutical agent and equipped with a precision-controlled dispensing valve (206);a mixing chamber (105) operatively connected to the dispensing mechanism, wherein the selected ingredients are homogenized before application;a plunger mechanism (101) configured to facilitate controlled dispensing of the final formulation;a flexible dispensing nozzle (106) in fluid communication with the mixing chamber, adapted for direct and targeted drug application to affected gingival areas;a volume adjustment mechanism (107) operatively coupled to the dispensing mechanism, allowing real-time manual modification of ingredient concentrations;a display window (108) configured to provide real-time feedback on ingredient selection, dosage levels, and dispensing status;wherein the ingredient cartridges (103, 202) are interchangeable and refillable, allowing customized treatment compositions based on patient requirements; characterized by a secure cartridge holder (201) with a locking mechanism to maintain proper alignment, prevent leakage, and ensure contamination-free storage of active ingredients.

2. The multi-cartridge dispensing device as claimed in Claim 1, wherein the flexible dispensing nozzle (106) is composed of medical -grade silicone, polyethylene (PE), or polypropylene (PP) for standard use, and biocompatiblethermoplastic elastomers (TPE) or polytetrafluoroethylene (PTFE) for optimizing formulation application to gingival tissues.

3. The multi -cartridge dispensing device as claimed in Claim 1, wherein the flexible dispensing nozzle (106) is interchangeable and configured to accommodate multiple nozzle types, including spray, jet, and drip nozzles, allowing control over formulation delivery based on viscosity, flow characteristics, and targeted application requirements.

4. The multi-cartridge dispensing device as claimed in Claim 1, wherein the volume adjustment mechanism (107) consists of a calibrated rotary dial enabling manual regulation of ingredient concentration in real time.

5. The multi -cartridge dispensing device as claimed in Claim 1, wherein the display window (108) provides real-time information on ingredient volumes, selected active agents, and dosage levels.

6. The multi-cartridge dispensing device as claimed in Claim 1, wherein the cartridge system (103, 202) includes graduated measurement indicators (203) for volume tracking and calibrated dispensing control of individual ingredient.

7. The multi-cartridge dispensing device as claimed in Claim 1, wherein the mixing chamber (105) is configured with anti-adherence coatings and a contamination-resistant internal structure to prevent cross-contamination and ensure uniform homogenization of the formulation before dispensing.

8. The multi -cartridge dispensing device as claimed in Claim 1, wherein the plunger mechanism (101) operates through a mechanical spring -loaded system ensuring precise metered dispensing, preventing residual leakage, and resetting automatically after each actuation for consistent performance.

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