Fused bicyclic compounds as VRK1 inhibitors

Abstract

Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and methods of using the compounds for treatment of cancer and inhibiting VRK1, as well as pharmaceutical compositions comprising such compounds.

Description

[0001] Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0002] FUSED BICYCLIC COMPOUNDS AS VRK1 INHIBITORS

[0003] CLAIM OF PRIORITY

[0004] This application claims the benefit of priority of U. S. Prov. Appl. Nos. 63 / 771,166, filed March 13, 2025; 63 / 771,181, filed March 13, 2025; 63 / 771,190, filed March 13, 2025; 63 / 818,492, filed June 5. 2025; 63 / 938,611, filed December 11. 2025; 63 / 938,639, filed December 11, 2025; and 63 / 938,661, filed December 11, 2025, each of which are incorporated herein by reference in their entirety.

[0005] FIELD OF THE DISCLOSURE

[0006] The present application is concerned with pharmaceutically active compounds. The disclosure provides compounds as well as their compositions and methods of use. The compounds are inhibitors of VRK1 and are useful in the treatment of various diseases including cancer.

[0007] BACKGROUND

[0008] Vaccinia related kinase (VRK) family are characterized by notable sequence homology to the virus-encoded Bl kinase (vvBl). VRK1 is a member of a subgroup of the casein kinase- 1 (CK1) family that also contains VRK2 and the pseudokinase VRK3 (J. Biol. Chem. 279:7934-7946 (2004)). VRK1 and VRK2 have been associated with various cellular processes, including cell replication, chromatin remodeling, and DNA damage response (ACS Med. Chem. Lett. 2019, 10, 9. 1266-1271).

[0009] VRK.1 is a serme / threonine-protein kinase that plays a pivotal role in regulating cell cycle, DNA damage response, nuclear condensation, and transcriptional control. VRK1 has been found to be overexpressed in multiple cancer types, including breast cancer, lung cancer, colorectal cancer, head and neck carcinomas, liver cancer, multiple myeloma, esophageal carcinoma, and all hematopoietic tumors, suggesting its involvement in tumorigenesis. Functionally, VRK.1 phosphorylates multiple substrates involved in both cell cycle progression and cell-cycle arrest. VRK1 has been reported to phosphorylate histone H3 and H2AX to regulate chromatin remodeling, transcription factors including p53, c-Jun, ATF2, CREB and Sox2 to activate of transcription, regulate assembly and disassembly of the nuclear envelop by phosphorylating BANF1 in cell cycle progression (Cancer Letters, Volume 503, 10 April 2021, Pages 117-128). Due to its role in cell proliferation and survivalAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0010] of tumor cells, VRK1 has emerged as a potential therapeutic target for cancer treatment.

[0011] Genetic knockdown evidence suggests that VRK1 depletion sensitizes cells to cancer treatments based on DNA damage such as ionizing radiation or doxorubicin by impairing the DNA damage response (Cellular and Molecular Life Sciences (2018) 75:2375-2388).

[0012] Depletion of VRK1 also slows tumor cell proliferation and tumor growth and metastasis in vivo (Oncogenesis volume 2, pagee48 (2013)). Genome-scale CRISPR / Cas9 loss of functions screens have identified a paralog-based synthetic lethality role of VRK.1 in adult and pediatric gliomas and neuroblastoma, where VRK2 is silenced by promoter methylation (JCI Insight. 2022;7(19):el58755; Cancer Res. 2022 Nov 2;82(21):4044-4057). The VRK.1 -VRK2 synthetic-lethal interaction was dependent on VKR1 kinase activity and was rescued by ectopic expression of VRK2 (Cancer Res. 2022 Nov 2;82(21):4044-4057). These results indicated that inhibiting VRK.1 kinase activity with small molecule inhibitors could be a viable therapeutic strategy7in VRK2-methylated GBM and neuroblastoma. Other then glioblastoma and neuroblastoma, preclinical data indiated other cancer ty pes where VRK1 plyas a critical role in cancer cell proliferation, including but not limited to Ewing Sarcoma, Astrocytoma, Diffuse Glioma, Bone Sarcoma, Solid tumors e.g. esophageal squamous cell carcinoma, colorectal adenocarcinoma (DepMap; Oncotarget. 2017; 8:65642-65658; Cancer Cell 28, 668-681, November 9, 2014; Pathology7- Research and Practice 214 (2018) 112-11). These observations suggests that inhibitors of VRK1 can be of potential use in cancer treatments, by themselves or in combinations, by facilitating inhibition of proliferation and at the same time sensitizing cells to treatments based on DNA damage.

[0013] Currently, there are no potent and specific small molecule inhibitors of VRK1. Some studies that have made progresses in developing VRK1 inhibitors including: (1) one study discovered an aminopyridine scaffold as a basis for VRK1 inhibitors and the most potent compound in this study had an IC50 value of 150 nM (ACS Med. Chem. Lett. 2019, 10, 9, 1266-1271); (2) Another study developed VRK1 inhibitors based on BI-D1870, a pteridinone inhibitor of RSK kinases. The optimized VRK1 inhibitor #36 was more selective and mimicked the cellular outcomes ofVRKl depletion (J. Med. Chem. 2024, 67, 11, 8609-8629).

[0014] Accordingly, there is a need for new compounds that inhibit VRK1 and which are useful in treating cancers. This application address this need and others.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0015] SUMMARY

[0016] The present disclosure provides, inter alia, compounds of Formula (I):

[0017]

[0018] or a pharmaceutically acceptable salt thereof, wherein constituent variables are defined herein.

[0019] The present disclosure further provides a VRK1 inhibitor, or a pharmaceutically acceptable salt thereof.

[0020] The present disclosure further provides a pharmaceutical composition comprising a compound disclosed herein, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipient or carrier.

[0021] The present disclosure further provides methods of inhibiting VRK1, comprising contacting the VRK1 with a VRK1 inhibitor, or a pharmaceutically acceptable salt thereof.

[0022] The present disclosure further provides methods of inhibiting VRK1, comprising administering to a patient a compound disclosed herein, or a pharmaceutically acceptable salt thereof. In some embodiments, the compounds, and pharmaceutically acceptable salts thereof, are selective for VRK1 over VRK2.

[0023] The present disclosure further provides methods of treating a disease or disorder associated with VRK1 activity, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of disclosed herein, or a pharmaceutically acceptable salt thereof. In some embodiments, the method is a method of treating sarcoma, colorectal adenocarcinoma, acute myeloid leukemia, glioblastoma, or neuroblastoma. In some embodiments, the method is a method of treating bone cancer, cancer of the neck and head, rectal cancer, esophageal cancer, sarcoma of soft tissue, neoplasm of the central nervous system (CNS), brain stem, glioma, colon cancer, Ewing’s sarcoma, brain cancer, astrocytoma, neuroblastoma, intestinal cancer, nervous system cancers, osteosarcoma, cancer of the small bowel (adenocarcinoma, lymphoma, carcinoid tumors, Kaposi’s sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, fibroma), or cancer of the large bowel (adenocarcinoma, tubular adenoma, villous adenoma, hamartoma, leiomyoma).Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0024] The present disclosure also provides use of a compound of disclosed herein, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for use in any of the methods described herein.

[0025] The present disclosure also provides a compound of disclosed herein, or a pharmaceutically acceptable salt thereof, for use in any of the methods described herein.

[0026] DETAILED DESCRIPTION

[0027] The present disclosure provides a VRK1 inhibitor, or a pharmaceutically acceptable salt thereof.

[0028] In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, covalently binds with a cysteine in VRK1. In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, binds with a water in the binding pocket of VRK1. In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, binds with Phel34 of VRK1. In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, binds with Lys71 of VRK1. In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, binds with Aspl32 of VRK1. In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, binds with the phosphate-binding loop of VRK1.

[0029] In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, covalently binds with a cysteine in VRK1, a water in the binding pocket of VRK1, and Phel34 ofVRKl.

[0030] In some embodiments, the VRK1 inhibitor, or a pharmaceutically acceptable salt thereof, covalently binds with a cysteine in VRK1, binds with a water in the binding pocket ofVRKl, binds with Phel34 ofVRKl, binds with Lys71 ofVRKl, binds with Asp 132 of VRK1, and binds with the phosphate-binding loop ofVRKl.

[0031] The VRK1 inhibitor can include a compound of the present disclosure, or a pharmaceutically acceptable salt thereof.

[0032] The present disclosure provides a compound of Formula (I) is:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0033]

[0034] or a pharmaceutically acceptable salt thereof, wherein:

[0035] n is 0, 1, 2, 3. 4, 5, or 6;

[0036] p is 0, 1, 2. 3. 4, 5, or 6;

[0037] r is 1 or 2;

[0038] X is N or CR1;

[0039] Z is N or CR2;

[0040] Y is -(Cy^m- Y1^-, wherein Y1is attached to Ring moiety B;

[0041] m is 1; s is 1; andY1is a bond; or

[0042] m is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); or m is 0; s is 1; andY1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O);

[0043] Cy1is C3- io cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, or 5-10 membered heteroaryl, which is optionally substituted by 1, 2, 3, 4, 5, or 6 independently selected R10substituents;

[0044] Ring moiety A is C3-12 cycloalky 1, 6-10 membered ary l, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;

[0045] Ring moiety B is C3-12 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;

[0046] R1is selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORhl, SRbl, NHORal, C(O)Rbl, C(O)NRclRdl, C(O)NRcl(ORal), C(O)ORal, OC(O)Rhl, OC(O)NRclRdl, NRclRdl, NRclNRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(O)NRclRdl, C(=NRel)Rbl, C(=NRel)NRclRdl, NRclC(=NRel)NRclRdl, NRclC(=NRel)Rbl, NRclS(O)NRclRdl, NRclS(O)Rbl, NRclS(O)2Rbl, NRclS(O)(=NRel)Rbl, NRclS(O)2NRclRdl, S(O)Rbl, S(O)NRclRdl, S(O)2Rbl, S(O)2NRclRdl, OS(O)(=NRel)Rbl, OS(O)2Rbl, S(O)(=NRel)Rbl, SF5,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0047] P(O)RflRgl, OP(O)(ORlll)(ORi1), P(O)(ORlll)(ORi1), and BRj’Rkl, wherein said Ci-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0048] each Ral, Rcl. and Rdlis independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroar l-C 1-4 alkyl. wherein said C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0049] or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0050] each Rblis independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1. 2, 3, or 4 independently selected R1Asubstituents;

[0051] each Relis independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;

[0052] each R11and Rglare independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0053] each R111and R11is independently selected from H, Ci-6 alkyl, Ci-6 haloalky 1, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl;

[0054] each R'1and Rklis independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any R'1and Rklattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0055] each R1Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11, SRa11, NHORa11, C(O)Rb11, C(O)NRcllRd11, C(O)NRcll(ORa11), C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllNRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, C(=NRell)Rb11, C(=NRell)NRcllRd11, NRcllC(=NRell)NRcllRd11, NRcllC(=NRell)Rb11, NRcllS(O)NRcllRd11, NRcllS(O)Rb11, NRcllS(O)2Rbn, NRcllS(O)(=NRell)Rb11, NRcllS(O)2NRcllRd11, S(O)Rb11, S(O)NRcllRd11, S(O)2Rb11, S(O)2NRcllRd11, OS(O)(=NRell)Rb11, OS(O)2Rb11, S(O)(=NRell)Rb11, SFs, P(O)RfllRg11, OP(O)(ORhll)(ORin), P(O)(ORhll)(ORin), and BRjllRk11, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7Cy cloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0056] each Ral1, Rcl1. and Rdl1is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0057] or, any Rcl1and Rdl1attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0058] heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0059] each Rbl1is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0060] each Rel1is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0061] each Rfl1and Rgl1are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0062] each Rhl1and R111is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0063] each Rjl1and Rkl1is independently selected from OH. C1-6 alkoxy, and C1-6 haloalkoxy;

[0064] or any R'11and Rkl1attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; each R1Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa12, SRa12, NH0Ra12. C(O)Rb12, C(O)NRc12Rd12, C(O)NRel2(ORa12), C(O)ORa12, OC(O)Rb12. OC(O)NRel2Rd12, NRc12Rd12, NRc12NRc12Rd12, NRcl2C(O)Rb12, NRc12C(O)ORa12, NRcl2C(O)NRc12Rd12, C(=NRel2)Rb12, C(=NRel2)NRc12Rd12, NRcl2C(=NRel2)NRc12Rd12, NRcl2C(=NRel2)Rb12, NRcl2S(O)NRc12Rd12, NRc12S(O)Rb12, NRcl2S(O)2Rb12, NRcl2S(O)(=NRel2)Rb12, NRcl2S(O)2NRc12Rd12, S(O)Rb12. S(O)NRc12Rd12, S(O)2Rb12. S(O)2NRc12Rd12.

[0065]

[0066] OS(O)(=NRel2)Rb12, OS(O)2Rb12, S(O)(=NRel2)Rb12, SFs, P(O)Rfl2Rg12,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0067] OP(O)(ORh12)(OR'12), P(O)(ORI112)(OR'12), and BRj,2Rk12, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0068] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0069] or, any Rcl2and Rdl2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalky 1 group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0070] each Rbl2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl. 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0071] each Re12is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0072] each Rfl2and Rgl2are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0073] each Rhl2and R112is independently selected from H, C1-6 alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0074] each RJ12and Rkl2is independently selected from OH, Ci-6 alkoxy, and Ci-6 haloalkoxy;

[0075] or any R'12and Rkl2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0076] R2is selected from H, D. halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocycloalkyl-C1-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORb2, SRb2, NHORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)NRo2(ORa2), C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2. NRc2NRc2Rd2, NRc2C(O)Rh2. NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(=NRc2)Rb2, C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)(=NRe2)Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2,

[0077]

[0078] S(O)NRc2Rd2, S(O)2Rb2, S(O)2NRc2Rd2, OS(O)(=NRe2)Rb2, OS(O)2Rb2, S(O)(=NRe2)Rb2, SFs, P(O)Rf2Rg2, OP(O)(ORb2)(OR12), P(O)(ORb2)(ORi2), and BRj2Rk2, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R2Asubstituents;

[0079] each Ra2, Rc2, and Rd2is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroar l-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R2Asubstituents;

[0080] or, any Rc2and Rd2attached to the same N atom, together with the N atom to w hich they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3. or 4 independently selected R2Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0081] each Rb2is independently selected from Ci-6 alky l, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alky l, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0082] each Re2is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocy cloalkyl-C 1-4 alky 1, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0083] each Rf2and Rg2are independently selected from H. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0084] each Rh2and R12is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alky l;

[0085] each R'2and Rk2is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any R|2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0086] each R2Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroary 1-C 1-4 alkyl, ORa21, SRa21, NHORa21, C(O)Rb21, C(O)NRc21Rd21, C(O)NRc21(ORa21). C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21NRe21Rd21, NRc21C(O)Rb21. NRc21C(O)ORa21, NRe21C(O)NRc21Rd21.

[0087] C(=NRe21)Rb21, C(=NRe21)NRc21Rd21, NRc21C(=NRe21)NRc21Rd21, NRc21C(=NRe21)Rb21, NRc21S(O)NRc21Rd21, NRc21S(O)Rb21, NRc21S(O)2Rb21, NRc21S(O)(=NRe21)Rb21, NRc21S(O)2NRc21Rd21, S(O)Rb21. S(O)NRc21Rd21, S(O)2Rb21. S(O)2NRc21Rd21, OS(O)(=NRc21)Rb21, OS(O)2Rb21, S(O)(=NRc21)Rb21, SF5. P(O)Rf21Rg21, OP(O)(ORh21)(ORi21), P(O)(ORh21)(ORi21), and BRj21Rk21. wherein said Ci-6 alkyl, C2-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0088] alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0089] each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyd. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0090] or, any Rc21and Rd21attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalky 1 group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R2Bsubstituents;

[0091] each Rb21is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0092] each Re21is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0093] each Rf21and Rg21are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alky nyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0094] each Rh21and Ri21is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0095] each R'21and Rk21is independently selected from OH, Ci-6 alkoxy, and Ci-6 haloalkoxy;

[0096] or any R'21and Rk21attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R2Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C'1-4 alkyl. ORa22, SRa22, NHORa22, C(O)Rb22, C(O)NRc22Rd22, C(O)NRc22(ORa22), C(O)ORa22, OC(O)Rb22, OC(O)NRc22Rd22, NRc22Rd22, NRc22NRc22Rd22, NRc22C(O)Rb22. NRc22C(O)ORa22, NRc22C(O)NRc22Rd22. C(=NRe22)Rb22, C(=NRe22)NRc22Rd22, NRc22C(=NRe22)NRc22Rd22, NRc22C(=NRe22)Rb22, NRc22S(O)NRc22Rd22, NRc22S(O)Rb22, NRc22S(O)2Rb22, NRc22S(O)(=NRe22)Rb22, NRc22S(O)2NRc22Rd22, S(O)Rb22, S(O)NRc22Rd22, S(O)2Rb22, S(O)2NRc22Rd22, OS(O)(=NRe22)Rb22, OS(O)2Rb22, S(O)(=NRe22)Rb22, SFs, P(O)Rf22Rg22,

[0097]

[0098] OP(O)(ORh22)(ORi22), P(O)(ORh22)(ORi22), and BR|22Rk22. wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0099] each Ra22, Rc22, and Rd22is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyd, 5-6 membered heteroaryl, C3-7Cycloalkyl-Ci-4alky 1, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyd, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroary l-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0100] or, any Re22and Rd22attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyd group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0101] each Rb22is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, pheny l, 4-7 membered heterocycloalky 1, 5-6 membered heteroaryl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0102] C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0103] each Re22is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0104] each Rf22and Rg22are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0105] each Rh22and Ri22is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0106] each R'22and Rk22is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0107] or any R'22and Rk22attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1. 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;

[0108] R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa3. SR113. NHORa3, C(O)Rb3, C(O)NRc3Rd3, C(O)NRc3(ORa3), C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, C(=NRe3)Rb3, C(=NRe3)NRc3Rd3, NRc3C(=NRe3)NRc3Rd3, NRc3C(=NRe3)Rb3, NRc3S(O)NRc3Rd3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)(=NRe3)Rb3, NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3. and S(O)2NRc3Rd3, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0109] each Ra3, Rc3. and Rd3is independently selected from H. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0110] membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C i-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said Ci-6 alkyd. C2-6 alkenyl, C2-6alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0111] each Rb3is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0112] each Re3is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C 1-6 haloalkoxy;

[0113] R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-4 cycloalkyl, ORa4, SRa4, NHORa4. C(O)Rb4. C(O)NRc4Rd4, C(O)NRc4(ORa4). C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4, NRc4S(O)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)(=NRe4)Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4. and S(O)2NRc4Rd4, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0114] each Ra4, Rc4, and Rd4is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0115] each Rb4is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0116] each Re4is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, and Ci-6 haloalkoxy;

[0117] each R5is independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa5, SRa5, NHORa5, C(O)Rb5, C(O)NRc5Rd5. C(O)NRc5(ORa5), C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(=NRe5)Rb5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(O)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)(=NRe5)Rb5. NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, S(O)2NRc5Rd5, OS(O)(=NRc5)Rb5, OS(O)2Rb5, S(O)(=NRe5)Rb5, SF5, P(O)Rf5Rg5, OP(O)(ORh5)(ORi5), P(O)(ORh5)(ORi5), and BRj5Rk5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents;

[0118] each Ra5, Rc5, and Rd5is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alky l, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0119] or, any Rc5and Rd5attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0120] each Rb5is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0121] membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1. 2, 3, or 4 independently selected R5Asubstituents;

[0122] each Re5is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0123] each R1’ and Rg3are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0124] each Rh5and Ri5is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl;

[0125] each Rj5and Rk5is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj5and Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1. 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;

[0126] each R5Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa51. SRa51, NHORa51, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51, NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, C(=NRe51)Rb51, C(=NRe51)NRc51Rd51, NRc51C(=NRe51)NRc51Rd51, NRc51C(=NRe51)Rb51, NRc51S(O)NRc51Rd51, NRc51S(O)Rb51, NRc51S(O)2Rb51, NRc51S(O)(=NRe51)Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51. S(O)2NRc51Rd51.

[0127]

[0128] OS(O)(=NRe51)Rb51, OS(O)2Rb51, S(O)(=NRe51)Rb51, SF5, P(O)Rf51Rg51, OP(O)(ORh51)(ORi51), P(O)(ORh51)(ORi51), and BR'51Rk51, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0129] heterocycloalkyl-C t-4 alkyl, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0130] each Ra51, Rc51, and Rd51is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0131] or, any Rc51and Rd51attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0132] each Rb51is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0133] each Re51is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0134] each Rf51and Rg51are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0135] each Rh51and R151is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl;

[0136] each Rj51and Rk51is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0137] or any Rj51and Rk51attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0138] each R6is independently selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORa6, SRa6, NHORa6, C(O)Rb6, C(O)NRc6Rd6, C(O)NRc6(ORa6), C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(O)NRc6Rd6. NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)(=NRe6)Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, S(O)2NRc6Rd6, OS(O)(=NRe6)Rb6, OS(O)2Rb6,

[0139]

[0140] S(O)(=NRe6)Rb6, SF5, P(O)Rf6Rg6, OP(O)(ORh6)(ORi6), P(O)(ORh6)(ORi6), and BR|6Rk6. wherein said C1-6 alkyl, C2-6 alkeny l. C2-6 alkyny l, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl -C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4alky 1 are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0141] each Ra6, Rc6. and Rd6is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1. 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0142] or, any Rc6and Rd6attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0143] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0144] membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1. 2, 3, or 4 independently selected R6Asubstituents;

[0145] each Re6is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0146] each Rf6and Rg6are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0147] each Rh6and Ri6is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl;

[0148] each Rj6and Rk6is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any R'6and Rk6attached to the same B atom, together wi th the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1. 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;

[0149] each R6Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61. SRa61, NHORa61, C(O)Rb61, C(O)NRc61Rd61, C(O)NRc61(ORa61), C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, C(=NRe61)Rb61, C(=NRe61)NRc61Rd61, NRc61C(=NRe61)NRc61Rd61, NRc61C(=NRe61)Rb61, NRc61S(O)NRc61Rd61, NRc61S(O)Rb61, NRc61S(O)2Rb61, NRc61S(O)(=NRe61)Rb61, NRc61S(O)2NRc61Rd61, S(O)Rb61, S(O)NRc61Rd61, S(O)2Rb61. S(O)2NRc61Rd61.

[0150]

[0151] OS(O)(=NRe61)Rb61, OS(O)2Rb61, S(O)(=NRe61)Rb61, SF5, P(O)Rf61Rg61, OP(O)(ORh61)(ORi61), P(O)(ORh61)(ORi61), and BR'61Rk61, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0152] heterocycloalkyl-C t-4 alkyl, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R6Bsubstituents;

[0153] each Ra61, Rc61, and Rd61is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0154] or, any Rc61and Rd61attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0155] each Rb61is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0156] each Re61is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0157] each Rf61and Rg61are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0158] each Rh61and Ri61is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl;

[0159] each Rj61and Rk61is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0160] or any R'61and Rk61atached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R6Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa62, SRa62, NHORa62, C(O)Rh62, C(O)NRc62Rd62, C(O)NRc62(ORa62), C(O)ORa62, OC(O)Rb62, OC(O)NRc62Rd62, NRc62Rd62, NRc62NRc62Rd62, NRc62C(O)Rb62, NRc62C(O)ORa62, NRc62C(O)NRc62Rd62, C(=NRe62)Rb62, C(=NRe62)NRc62Rd62, NRc62C(=NRe62)NRc62Rd62, NRc62C(=NRe62)Rb62, NRc62S(O)NRc62Rd62, NRc62S(O)Rb62, NRc62S(O)2Rb62, NRc62S(O)(=NRc62)Rb62, NRc62S(O)2NRc62Rd62, S(O)Rb62, S(O)NRc62Rd62, S(O)2Rb62, S(O)2NRc62Rd62, OS(O)(=NRe62)Rb62, OS(O)2Rb62, S(O)(=NRe62)Rb62, SF5, P(O)Rf62Rg62, OP(O)(ORh62)(ORi62), P(O)(ORh62)(ORi62), and BRj62Rk62, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0161] each Ra62, Rc62, and Rd62is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0162] or, any Rc62and Rd62attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0163] each Rb62is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0164] 6 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0165] each Re62is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0166] each Rf62and Rg62are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0167] each Rh62and Ri62is independently selected from H. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l;

[0168] each Rj62and Rk62is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0169] or any Rj62and Rk62attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; each R60is independently selected from H. D, C1-6 alkyl, and C1-6 haloalkyl;

[0170] or R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety7, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0171] each R7is independently selected from D, halo, CN. NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa7, SRa7, NHORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)NRc7(ORa7), C(O)ORa7, OC(O)Rb7, OC(O)NRe7Rd7, NRe7Rd7, NRe7NRc7Rd7. NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRe7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(O)NRc7Rd7, NRc7S(O)Rb7, NRc7S(O)2Rb7, NRc7S(O)(=NRe7)Rb7, NRc7S(O)2NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, S(O)2NRc7Rd7, OS(O)(=NRe7)Rb7, OS(O)2Rb7,

[0172]

[0173] S(O)(=NRc7)Rb7. SF5, P(O)Rf7Rg7. OP(O)(ORh7)(ORi7). P(O)(ORh7)(ORi7). and BRj7Rk7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0174] membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0175] each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0176] or, any Rc7and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0177] each Rb7is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl. 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0178] each Re7is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3- 10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;

[0179] each Rf7and Rg7are independently selected from H. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocy cloalkyl-C 1-4 alky 1, and 5-10 membered heteroaryl-C 1-4 alkyl;

[0180] each Rh7and Ri7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0181] 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C t-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alk l;

[0182] each Rj7and Rk7is independently selected from OH, Ci-6 alkoxy, and Ci-6 haloalkoxy; or any Rj7and Rk7attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R7Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyd, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa71, SRa71, NHORa71, C(O)Rb71, C(O)NRc71Rd71. C(O)NRc71(ORa71). C(O)ORa71, OC(O)Rb71, OC(O)NRc71Rd71, NRc71Rd71, NRc71NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, C(=NRe71)Rb71, C(=NRe71)NRc71Rd71, NRc71C(=NRe71)NRc71Rd71, NRc71C(=NRe71)Rb71, NRc71S(O)NRc71Rd71, NRc71S(O)Rb71, NRc71S(O)2Rb71, NRc71S(O)(=NRe71)Rb71, NRc71S(O)2NRc71Rd71, S(O)Rb71. S(O)NRc71Rd71, S(O)2Rb71. S(O)2NRc71Rd71, OS(O)(=NRe71)Rb71, OS(O)2Rb71, S(O)(=NRe71)Rb71, SF5, P(O)Rf71Rg71, OP(O)(ORh71)(ORi71), P(O)(ORh71)(ORi71), and BR'71Rk71, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0183] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alky l. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0184] or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0185] each Rb71is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0186] each Re71is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0187] each Rf71and Rg71are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0188] each Rh71and Ri71is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0189] each Rj71and Rk71is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0190] or any Rj71and Rk71attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl; each R7Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa72, SRa72, NHORa72, C(O)Rb72, C(O)NRc72Rd72, C(O)NRc72(ORa72), C(O)ORa72, OC(O)Rb72, OC(O)NRc72Rd72, NRc72Rd72, NRc72NRc72Rd72, NRc72C(O)Rb72. NRc72C(O)ORa72, NRc72C(O)NRc72Rd72. C(=NRe72)Rb72, C(=NRe72)NRc72Rd72, NRc72C(=NRe72)NRc72Rd72, NRc72C(=NRe72)Rb72, NRc72S(O)NRc72Rd72, NRc72S(O)Rb72, NRc72S(O)2Rb72, NRc72S(O)(=NRe72)Rb72, NRc72S(O)2NRc72Rd72, S(O)Rb72, S(O)NRc72Rd72, S(O)2Rb72, S(O)2NRc72Rd72,

[0191]

[0192] OS(O)(=NRe72)Rb72, OS(O)2Rb72, S(O)(=NRe72)Rb72, SF5, P(O)Rf72Rg72, OP(O)(ORh72)(ORi72), P(O)(ORh72)(ORi72), and BRj72Rk72, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0193] 5-6 membered heteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0194] each Ra72, Rc72, and Rd72is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;

[0195] or, any Rc72and Rd72attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0196] each Rb72is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0197] each Re72is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0198] each Rf72and Rg72are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0199] each Rh72and Ri72is independently selected from H. C1-6 alkyl. C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;

[0200] each Rj72and Rk72is independently selected from OH. C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0201] or any Rj72and Rk72attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0202] Rwis a covalent warhead moiety7having a reactive functional group capable of covalently binding to one or more cysteine residues in a protein;

[0203] each R10is independently selected from D. halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORal°, SRal°, NHORa10, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)NRcl0(ORal°), C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°. NRcl0S(O)NRcl0Rdl°, NRcl0S(O)Rbl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)Rbl°, S(O)NRcl0Rdl°, S(O)2Rbl°, and S(O)2NRc10Rd10, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0204] each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0205] or, any Rc10and Rd10attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocy cloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R3Asubstituents;

[0206] each Rb10is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents; andAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0207] each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl. cyano-Ci-3 alkyl. HO-C1-3 alkyl. C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, N(CDs)2, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di (C 1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0208] In some embodiments, the compound is of Formula (I):

[0209]

[0210] or a pharmaceutically acceptable salt thereof, wherein:

[0211] n is 0, 1, 2, 3, 4, 5, or 6;

[0212] p is 0, 1, 2, 3, 4, 5, or 6;

[0213] r is 1 or 2;

[0214] X is N or CR1;

[0215] Z is N or CR2;

[0216] Y is -(Cy^m- Y^s-, wherein Y1is attached to Ring moiety B;

[0217] m is 1; s is 1; and Y1is a bond; or

[0218] m is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); m is 0; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O);

[0219] Cy1is C3- 10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, or 5-10 membered heteroaryl, which is optionally substituted by 1, 2, 3, 4, 5, or 6 independently selected R10substituents;

[0220] Ring moiety A is C3-12 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0221] Ring moiety B is C3-12 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;

[0222] R1is selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORbl. SRbl. NHORal, C(O)Rbl. C(O)NRclRdl, C(O)NRcl(ORal). C(O)ORal. OC(O)Rbl. OC(O)NRclRdl, NRclRdl, NRclNRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(O)NRclRdl, C(=NRel)Rbl, C(=NRel)NRclRdl, NRclC(=NRel)NRclRdl, NRclC(=NRel)Rbl, NRclS(O)NRclRdl, NRclS(O)Rbl, NRclS(O)2Rbl, NRc1S(O)(=NRe1)Rb1, NRclS(O)2NRclRdl, S(O)Rbl, S(O)NRclRdl, S(O)2Rbl, S(O)2NRclRdl, OS(O)(=NRcl)Rbl, OS(O)2Rbl. S(O)(=NRcl)Rbl. SF5,

[0223]

[0224] P(O)Rf1Rg1, OP(O)(ORh1)(ORi1), P(O)(ORh1)(ORi1), and BRj1Rk1, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0225] each Ral, Rcl, and Rdlis independently selected from H, C1-6 alkyl, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0226] or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0227] each Rblis independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0228] membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1. 2, 3, or 4 independently selected R1Asubstituents;

[0229] each Relis independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0230] each R11and Rglare independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0231] each Rhland R11is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl;

[0232] each Ri1and Rklis independently selected from OH, C1-6 alkoxy, and C 1-6 haloalkoxy; or any R'1and Rklattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1. 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;

[0233] each R1Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11. SRa11, NHORa11, C(O)Rb11, C(O)NRcllRd11, C(O)NRcll(ORa11), C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllNRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, C(=NRell)Rb11, C(=NRell)NRcllRd11, NRcllC(=NRell)NRcllRd11, NRcllC(=NRell)Rb11, NRcllS(O)NRcllRd11, NRcllS(O)Rb11, NRcllS(O)2Rb11, NRcllS(O)(=NRell)Rb11, NRcllS(O)2NRcllRd11, S(O)Rb11, S(O)NRellRd11, S(O)2Rb11. S(O)2NRcllRd11.

[0234] OS(O)(=NRell)Rb11, OS(O)2Rb11, S(O)(=NRell)Rb11, SFs, P(O)RfllRg11, OP(O)(ORh11)(ORi11), P(O)(ORh11)(ORi11), and BR'11Rk11, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0235] heterocycloalkyl-C t-4 alkyl, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R1Bsubstituents;

[0236] each Ral1, Rcl1, and Rdl1is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0237] or, any Rcl1and Rdl1attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0238] each Rbl1is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0239] each Rel1is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0240] each Rfl1and Rgl1are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0241] each Rhl1and R111is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl;

[0242] each RJ11and Rkl1is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0243] or any R'11and Rkl 1atached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R1Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa12, SRa12, NHORa12, C(O)Rh12, C(O)NRc12Rd12, C(O)NRcl2(ORa12), C(O)ORa12, OC(O)Rb12, OC(O)NRc12Rd12, NRc12Rd12, NRc12NRc12Rd12, NRcl2C(O)Rb12, NRc12C(O)ORa12, NRcl2C(O)NRc12Rd12, C(=NRel2)Rb12, C(=NRel2)NRc12Rd12, NRcl2C(=NRel2)NRc12Rd12, NRcl2C(=NRel2)Rb12, NRcl2S(O)NRc12Rd12, NRcl2S(O)Rb12, NRc12S(O)2Rb12, NRcl2S(O)(=NRcl2)Rb12, NRcl2S(O)2NRc12Rd12, S(O)Rb12, S(O)NRc12Rd12, S(O)2Rb12, S(O)2NRc12Rd12, OS(O)(=NRel2)Rb12, OS(O)2Rb12, S(O)(=NRel2)Rb12, SF5, P(O)Rfl2Rg12, OP(O)(ORhl2)(ORi12), P(O)(ORhl2)(ORi12), and BRjl2Rk12, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0244] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0245] or, any Rcl2and Rdl2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0246] each Rbl2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0247] 6 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0248] each Rel2is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0249] each Rf12and Rg12are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0250] each Rh12and Ri12is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl;

[0251] each R'12and Rkl2is independently selected from OH. C1-6 alkoxy, and C1-6 haloalkoxy;

[0252] or any R>12and Rkl2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; R2is selected from H, D. halo. CN, NO2, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalky l, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered ary I-C1-4 alky l, 4-10 membered heterocycloalky I-C1-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, OR1’2, SRb2. NHORa2. C(O)Rb2. C(O)NRc2Rd2, C(O)NRc2(ORa2). C(O)ORa2. OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(=NRe2)Rb2, C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)(=NRe2)Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, S(O)2NRc2Rd2, OS(O)(=NRe2)Rb2, OS(O)2Rb2, S(O)(=NRe2)Rb2, SFs,

[0253]

[0254] P(O)Rf2Rg2, OP(O)(ORh2)(ORi2), P(O)(ORh2)(ORi2), and BRj2Rk2. wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered ary 1-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R2A

[0255] substituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0256] each Ra2, Rc2, and Rd2is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0257] or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0258] each Rb2is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0259] each Re2is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0260] each Rf2and Rg2are independently selected from H. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alky l, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0261] each Rh2and Ri2is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10cycloalkyl-C1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alky l;

[0262] each R'2and Rk2is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0263] or any R'2and Rk2atached to the same B atom, together with the B atom to which they are atached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R2Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa21, SRa21, NHORa21, C(O)Rh21, C(O)NRc21Rd21, C(O)NRc21(ORa21), C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, C(=NRe21)Rb21, C(=NRe21)NRc21Rd21, NRc21C(=NRe21)NRc21Rd21, NRc21C(=NRe21)Rb21, NRc21S(O)NRc21Rd21, NRc21S(O)Rb21, NRc21S(O)2Rb21, NRc21S(O)(=NRc21)Rb21, NRc21S(O)2NRc21Rd21, S(O)Rb21, S(O)NRc21Rd21, S(O)2Rb21, S(O)2NRc21Rd21, OS(O)(=NRe21)Rb21, OS(O)2Rb21, S(O)(=NRe21)Rb21, SF5, P(O)Rf21Rg21, OP(O)(ORh21)(ORi21), P(O)(ORh21)(ORi21), and BRj21Rk21, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0264] each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0265] or, any Rc21and Rd21atached to the same N atom, together with the N atom to which they are atached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0266] each Rb21is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0267] 6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0268] each Re21is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0269] each Rf21and Rg21are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0270] each Rh21and Ri21is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl;

[0271] each R'21and Rk21is independently selected from OH. C1-6 alkoxy, and C1-6 haloalkoxy;

[0272] or any R'21and Rk21attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R2Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa22, SRa22, NHORa22, C(O)Rb22, C(O)NRc22Rd22, C(O)NRc22(ORa22). C(O)ORa22, OC(O)Rb22, OC(O)NRc22Rd22, NRc22Rd22, NRc22NRc22Rd22, NRc22C(O)Rb22, NRc22C(O)ORa22, NRc22C(O)NRc22Rd22, C(=NRe22)Rb22, C(=NRe22)NRc22Rd22, NRc22C(=NRe22)NRc22Rd22, NRc22C(=NRe22)Rb22, NRc22S(O)NRc22Rd22, NRc22S(O)Rb22, NRc22S(O)2Rb22, NRc22S(O)(=NRe22)Rb22, NRc22S(O)2NRc22Rd22, S(O)Rb22. S(O)NRc22Rd22, S(O)2Rb22. S(O)2NRc22Rd22, OS(O)(=NRe22)Rb22, OS(O)2Rb22, S(O)(=NRe22)Rb22, SF5, P(O)Rf22Rg22,

[0273]

[0274] OP(O)(ORh22)(OR122), P(O)(ORh22)(OR122), and BR'22Rk22, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0275] each Ra22, Rc22, and Rd22is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0276] or, any Rc22and Rd22attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalky 1 group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0277] each Rb22is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkyny l, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0278] each Re22is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0279] each Rf22and Rg22are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0280] each Rh22and R122is independently selected from H, C1-6 alky 1, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0281] each R'22and Rk22is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0282] or any R'22and Rk22attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0283] R3is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa3, SRa3, NHORa3, C(O)Rb3, C(O)NRc3Rd3, C(O)NRc3(ORa3), C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, C(=NRe3)Rb3. C(=NRe3)NRc3Rd3. NRc3C(=NRe3)NRc3Rd3, NRc3C(=NRe3)Rb3, NRc3S(O)NRc3Rd3. NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)(=NRe3)Rb3. N

[0284]

[0285] Rc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0286] each Ra3, Rc3, and Rd3is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkyny l, C1-6 haloalkyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;

[0287] each Rb3is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0288] each Re3is independently selected from H, OH, CN, C1-6 alkyl, C 1-6 alkoxy, C1-6 haloalkyl, and C 1-6 haloalkoxy;

[0289] R4is selected from H, D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-4 cycloalkyl, ORa4. SRa4. NHORa4, C(O)Rh4. C(O)NRc4Rd4, C(O)NRc4(ORa4). C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rh4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4, NRc4S(O)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)(=NRe4)Rb4. NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rh4. and S(O)2NRc4Rd4, wherein said C1-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0290] alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally- substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0291] each Ra4, Rc4, and Rd4is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky-1, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0292] each Rb4is independently selected from C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0293] each Re4is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C 1-6 haloalkoxy;

[0294] each R5is independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alky 1, ORa5, SRa5, NH0Ra5, C(O)Rb5, C(O)NRc5Rd5, C(O)NRc5(ORa5), C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(=NRe5)Rb5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5. NRc5C(=NRe5)Rb5. NRc5S(O)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)(=NRe5)Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, S(O)2NRc5Rd5, OS(O)(=NRe5)Rb5, OS(O)2Rb5,

[0295]

[0296] S(O)(=NRe5)Rb5, SF5, P(O)Rf5Rg5, OP(O)(ORh5)(ORi5), P(O)(ORh5)(ORi5), and BRj5Rk5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0297] each Ra5, Rc5. and Rd5is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0298] 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C t-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary l-Ci-4 alk l. wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alk 1, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R5Asubstituents;

[0299] or, any Rc3and Rd5attached to the same N atom, together wi th the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3. or 4 independently selected R5Asubstituents;

[0300] each Rb3is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0301] each Re3is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalky l, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alky nyl, C3- 10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl;

[0302] each Rf5and Rg5are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky l, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl;

[0303] each Rh5and Ri5is independently selected from H, C1-6 alkyl, C 1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alky 1;

[0304] each Rj5and Rk5is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj5and Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0305] each R5Ais independently selected from D, halo, CN, NO2, C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa51, SRa51, NHORa31, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51, NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, C(=NRe51)Rb51, C(=NRe51)NRc51Rd51, NRc51C(=NRe51)NRc51Rd51, NRc51C(=NRe51)Rb51, NRc51S(O)NRc51Rd51, NRc51S(O)Rb51, NRc51S(O)2Rb51, NRc51S(O)(=NRe51)Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51, S(O)2NRc51Rd51,

[0306]

[0307] OS(O)(=NRe51)Rb51, OS(O)2Rb51, S(O)(=NRe51)Rb51, SF5, P(O)Rf31Rg31, OP(O)(ORh51)(ORi51), P(O)(ORb51)(ORi31), and BRj51Rk51, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroary 1-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0308] each Ra51, Rc51, and Rd51is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0309] or, any Rc51and Rd51attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0310] each Rb51is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky 1, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroary 1-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0311] each Rc51is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalky l, phenyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0312] heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0313] each Rf51and Rg51are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0314] each R1’51and R151is independently selected fromH. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky 1, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l;

[0315] each Rj51and Rk51is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0316] or any Rj51and Rk51attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0317] each R6is independently selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkyny l, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered ary l-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa6, SRa6, NHORa6, C(O)Rb6, C(O)NRc6Rd6. C(O)NRc6(ORa6), C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)(=NRe6)Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, S(O)2NRc6Rd6, OS(O)(=NRe6)Rb6, OS(O)2Rb6,

[0318]

[0319] S(O)(=NRe6)Rb6, SF5, P(O)Rf6Rg6, OP(O)(ORh6)(ORi6), P(O)(ORh6)(ORi6), and BRj6Rk6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalky l, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalky l, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R6Asubstituents;

[0320] each Ra6, Rc6, and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkyny l, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, whereinAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0321] said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0322] or, any Rc6and Rd6attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0323] each Rb6is independently selected from C1-6 alky l, C1-6 haloalky 1, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky 1, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0324] each Re6is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;

[0325] each Rf6and Rg6are independently selected from H. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;

[0326] each Rh6and Ri6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alky l;

[0327] each Rj6and Rk6is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj6and Rk6attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0328] each R6Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0329] membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C i-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61. SRa61, NHORa61, C(O)Rb61, C(O)NRc61Rd61, C(O)NRc61(ORa61), C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, C(=NRe61)Rb61, C(=NRe61)NRc61Rd61, NRc61C(=NRe61)NRc61Rd61, NRc61C(=NRe61)Rb61, NRc61S(O)NRc61Rd61, NRc61S(O)Rb61, NRc61S(O)2Rb61, NRc61S(O)(=NRe61)Rb61, NRc61S(O)2NRc61Rd61, S(O)Rb61, S(O)NRc61Rd61, S(O)2Rb61. S(O)2NRc61Rd61.

[0330]

[0331] OS(O)(=NRe61)Rb61, OS(O)2Rb61, S(O)(=NRe61)Rb61, SF5, P(O)Rf61Rg61, OP(O)(ORh61)(ORi61), P(O)(ORh61)(ORi61), and BRi61Rk61, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0332] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0333] or, any Rc61and Rd61attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R6Bsubstituents;

[0334] each Rb61is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0335] each Re61is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0336] each Rf61and Rg61are independently selected from H, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0337] each Rh61and Ri61is independently selected from H, Ci-e alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;

[0338] each Rj61and Rk61is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0339] or any Rj61and Rk61attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl; each R6Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa62, SRa62, NHORa62, C(O)Rb62, C(O)NRc62Rd62, C(O)NRc62(ORa62), C(O)ORa62, OC(O)Rb62, OC(O)NRc62Rd62, NRc62Rd62, NRc62NRc62Rd62, NRc62C(O)Rb62, NRc62C(O)ORa62, NRc62C(O)NRc62Rd62.

[0340] C(=NRe62)Rb62, C(=NRe62)NRc62Rd62, NRc62C(=NRe62)NRc62Rd62, NRc62C(=NRe62)Rb62, NRc62S(O)NRc62Rd62, NRc62S(O)Rb62, NRc62S(O)2Rb62, NRc62S(O)(=NRe62)Rb62, NRc62S(O)2NRc62Rd62, S(O)Rb62, S(O)NRc62Rd62, S(O)2Rb62, S(O)2NRc62Rd62, OS(O)(=NRe62)Rb62, OS(O)2Rb62, S(O)(=NRe62)Rb62, SF5, P(O)Rf62Rg62, OP(O)(ORh62)(ORi62), P(O)(ORh62)(ORi62), and BRj62Rk62, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0341] each Ra62, Rc62, and Rd62is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0342] membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0343] or, any Rc62and Rd62attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0344] each Rb62is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0345] each Re62is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0346] each Rf62and Rg62are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0347] each Rh62and Ri62is independently selected from H. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky 1, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l;

[0348] each Rj62and Rk62is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0349] or any Rj62and Rk62attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; each R60is independently selected from H. D, C1-6 alkyl, and C1-6 haloalkyl;

[0350] or R6and R60, together with the carbon atom to which they are attached, form a 4-10 membered heterocy cloalky l moiety7, which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0351] each R7is independently selected from D, halo, CN. NO2. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalky l, 6-10 membered aryl, 4-10 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0352] heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa7, SRa7, NHORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)NRc7(ORa7), C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(O)NRc7Rd7. NRc7S(O)Rb7, NRc7S(O)2Rb7, NRc7S(O)(=NRe7)Rb7. NRc7S(O)2NRc7Rd7, S(O)Rb7. S(O)NRc7Rd7, S(O)2Rb7, S(O)2NRc7Rd7, OS(O)(=NRe7)Rb7, OS(O)2Rb7,

[0353]

[0354] S(O)(=NRe7)Rb7, SF5, P(O)Rf7Rg7, OP(O)(ORh7)(ORi7), P(O)(ORh7)(ORi7), and BRj7Rk7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0355] each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalky l, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0356] or, any Rc7and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0357] each Rb7is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0358] each Re7is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0359] membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalky l-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0360] each Rf7and Rg7are independently selected from H, C1-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0361] each Rh7and Ri7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalky l, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;

[0362] each Rj7and Rk7is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj7and Rk7attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0363] each R7Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-Ci-4 alky 1, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa71, SRa71, NHORa71, C(O)Rb71, C(O)NRc71Rd71. C(O)NRc71(ORa71). C(O)ORa71, OC(O)Rb71, OC(O)NRc71Rd71, NRc71Rd71, NRc71NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, C(=NRe71)Rb71, C(=NRe71)NRc71Rd71, NRc71C(=NRe71)NRc71Rd71, NRc71C(=NRe71)Rb71, NRc71S(O)NRc71Rd71, NRc71S(O)Rb71, NRc71S(O)2Rb71, NRc71S(O)(=NRe71)Rb71, NRc71S(O)2NRc71Rd71, S(O)Rb71. S(O)NRc71Rd71, S(O)2Rb71. S(O)2NRc71Rd71,

[0364]

[0365] OS(O)(=NRe71)Rb71, OS(O)2Rb71, S(O)(=NRe71)Rb71, SF5, P(O)Rf71Rg71, OP(O)(ORh71)(ORi71), P(O)(ORh71)(ORi71), and BRi71Rk71, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkyny l, C1-6 haloalky l, C3-7 cycloalky l, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky l-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0366] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0367] C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0368] or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0369] each Rb71is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0370] each Re71is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0371] each Rf71and Rg71are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0372] each Rh71and Ri71is independently selected from H, C1-6 alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;

[0373] each Rj71and Rk71is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0374] or any Rj71and Rk71attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; each R7Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa72, SRa72, NHORa72,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0375] C(O)Rb72, C(O)NRc72Rd72, C(O)NRc72(ORa72). C(O)ORa72, OC(O)Rb72, OC(O)NRc72Rd72, NRc72Rd72, NRc72NRc72Rd72, NRc72C(O)Rb72. NRc72C(O)ORa72, NRc72C(O)NRc72Rd72.

[0376] C(=NRe72)Rb72, C(=NRe72)NRc72Rd72, NRc72C(=NRe72)NRc72Rd72, NRc72C(=NRe72)Rb72NRc72S(O)NRc72Rd72, NRc72S(O)Rb72, NRc72S(O)2Rb72, NRc72S(O)(=NRe72)Rb72, NRc72S(O)2NRc72Rd72, S(O)Rb72, S(O)NRc72Rd72, S(O)2Rb72S(O)2NRc72Rd72, OS(O)(=NRe72)Rb72, OS(O)2Rb72, S(O)(=NRe72)Rb72, SF5, P(O)Rf72Rg72, OP(O)(ORh72)(ORi72), P(O)(ORb72)(ORi72), and BRj72Rk72, wherein said Ci-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C.3-7cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;

[0377] each Ra72, Rc72, and Rd72is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0378] or, any Rc72and Rd72attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyd group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0379] each Rb72is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky 1, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0380] each Re72is independently selected from H, OH. CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyd-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0381] each Rf72and Rg72are independently selected from H. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0382] heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0383] each Rh72and Ri72is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0384] each Rj72and Rk72is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;

[0385] or any Rj72and Rk72attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0386] Rwis a covalent warhead moiety having a reactive functional group capable of covalently binding to one or more cysteine residues in a protein;

[0387] each R10is independently selected from D, halo, CN, NO2, C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORal°, SRal°, NHORa10, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)NRcl0(ORal°), C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°. NRcl0S(O)NRcl0Rdl°, NRcl0S(O)Rbl°, NRcl0S(O)2Rbl°. NRcl0S(O)2NRc10Rd10. S(O)Rbl°, S(O)NRcl0Rdl°, S(O)2Rbl°, and S(O)2NRc10Rd10, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;

[0388] each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0389] or, any Rc1° and Rd1° attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents;

[0390] each Rbl° is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents; and

[0391] each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl. cyano-Ci-3 alkyl. HO-C1-3 alkyl. C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, thio, C 1-3 alkylthio, C 1-3 alkylsulfinyl, C 1-3 alkylsulfonyl, carbamyl, C 1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C 1-3 alky lcarbonyl, C1-3 alkoxycarbonyl, C 1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino. C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(C 1-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0392] Alternatively, in the preceding embodiment, Rwis a means for covalently binding to cysteine residue in a protein (e.g., VRK1). In some embodiments,

[0393]

[0394] is a means for covalently binding to cysteine residue in the VRK1 protein.

[0395] Chemical moieties capable of binding to cysteine are known in the art and can include, but are not limited to those described in Huang, et al., “Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development’; Molecules 2022, 27, 7728; and the sections discussing cysteine warheads in the following references: Mehta, et al., ‘'The expanding repertoire of covalent warheads for drug discovery”. Drug Discov Today 2023, 28(12): 103799; and Martin, et al., “Characterising covalent warhead reactivity ”, Bioorg Med Chem 2019, 15;27(10):2066-2074, each of which is incorporated herein in its entirety.

[0396] In some embodiments, Rwis:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0397]

[0398] L1is -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-, -L-S(O)-, -L-S(O)2-, -L-NR9S(O)-, -L- OS(O)-, -L-NR9S(O)2-, or -L-OS(O)2-, wherein L1is atached to Ring moiety B through the L linking group;

[0399] L2is -L-, -L-O-, -L-NR9-, -L-S-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-, -L-S(O)-, -L- S(O)2-, -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)NR9-, -L-NR9S(O)O-, -L-OS(O)NR9-, -L-NR9S(O)2-. -L-OS(O)2-, -L-NR9S(O)2NR9-, -L-NR9S(O)2O-, -L-S(O)(NR9)-, -L-S(O)2(NR9)-, or -L-OS(O)2NR9-, wherein L2is atached to Ring moiety B through the L linking group;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0400] L3is -L-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-. -L-S(O)-, -L-S(O)2-, -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)2-, or -L-OS(O)2-, wherein L3is atached to Ring moiety B through the L linking group;

[0401] L4is -L-, -L-O-, L-S-, or -L-NR9-, wherein L4is atached to Ring moiety B through the L linking group;

[0402] L6is -L-, -L-O-, -L-NR9-, -L-S-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-. -L-S(O)-, -L-S(O)2-. -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)NR9-, -L-NR9S(O)O-, -L-OS(O)NR9-. -L-NR9S(O)2-, -L-OS(O)2-, -L-NR9S(O)2NR9-, -L-NR9S(O)2O-, -L-S(O)(NR9)-, -L-S(O)2(NR9)-, or -L-OS(O)2NR9-, wherein L6is atached to Ring moiety D through the L linking group;

[0403] L is a bond or Ci-6 alkylene, wherein said Ci-6 alky lene is optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents; or

[0404] L is -O-Ci-6 alkyl or -N(RN)-CI-6 alkyl, wherein L is atached to Ring moiety A via the oxygen of the -O-Ci-6 alkyd or the nitrogen atom of the -N(RN)-CI-6 alkyl group;

[0405] each RNis independently H or Ci-6 alkyl;

[0406] Ring D is a 4-12 membered heterocycloalkyl, C3-12 cycloalkyl, Ce-io aryl, or a 5-10 membered heteroaryl, each of which is optionally substituted with 1, 2, 3, or 4 independently selected C1-6 alkyd groups;

[0407] Gis O or NR9;

[0408] each t is independently 0, 1, 2, or 3;

[0409] each R81and R83are independently selected from H, D, halo, NO2, CN. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyd-C 1-4 alkyd, phenyl-C 1-4 alkyd, 4-7 membered heterocycloalky I-C1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alky 1. ORa8, SRa8, NHORa8. C(O)Rb8. C(O)NRc8Rd8, C(O)NRc8(ORa8). C(O)ORa8. OC(O)Rb8, OC(O)NRc8Rd8, NRc8Rd8, NRc8NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8, NRc8C(O)NRc8Rd8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, NRc8C(=NRe8)NRc8Rd8, NRc8C(=NRe8)Rb8, NRc8S(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8, NRc8S(O)(=NRe8)Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, S(O)2NRc8Rd8, OS(O)(=NRe8)Rb8, OS(O)2Rb8, S(O)(=NRe8)Rb8, SFs,

[0410]

[0411] P(O)Rf8Rg8, OP(O)(ORh8)(ORi8), P(O)(ORh8)(ORi8), and BRj8Rk8; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyd-C 1-4 alkyd, phenyl-C 1-4 alkyd, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-6 membered heteroary d-C 1-4 alkyl are each optionally substituted by 1, 2, 3. or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0412] each R82is independently selected from H, D, halo, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, C(O)Rb8, C(O)NRc8Rd8, C(O)ORa8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, and S(O)2NRc8Rd8; wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cy cl oalkyl-C 1-4 alkyl, ph enyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;

[0413] each Ra8, Rc8. and Rd8is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0414] each Rb8is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0415] each Re8is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0416] each Rf8and Rg8are independently selected from H. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;

[0417] each Rh8and Ri8is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0418] heteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;

[0419] each Rj8and Rk8is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj8and Rk8attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; or any two R81and R82together with the atoms to which they are attached, form C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, or 5-6-membered heteroaryl ring, each of which is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0420] each R9is independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, ORa9, SRa9, NH0Ra9, C(O)Rb9, C(O)NRc9Rd9, C(O)NRc9(ORa9), C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)ORa9, NRc9C(O)NRc9Rd9, C(=NRe9)Rb9. C(=NRe9)NRc9Rd9.

[0421] NRc9C(=NRe9)NRc9Rd9, NRc9C(=NRe9)Rb9, NRc9S(O)NRc9Rd9, NRc9S(O)Rb9, NRc9S(O)2Rb9, NRc9S(O)(=NRe9)Rb9, NRc9S(O)2NRc9Rd9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, S(O)2NRc9Rd9, OS(O)(=NRe9)Rb9, OS(O)2Rb9, and S(O)(=NRe9)Rb9, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;

[0422] each Ra9, Rc9, and Rd9is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl. C2-6 alkynyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0423] or, any Rc9and Rd9attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalky 1 group, which is optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0424] each Rb9is independently selected from Ci-6 alky l, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents; and

[0425] each Re9is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl.

[0426] In some embodiments, Rwis selected from:

[0427] I— [_2R82 I — L2R82i — L2R821— L1t-L1)=( )=( )=(?^Cl / Br. R82R82. R82C(O)R8\ R82S(O)tR83

[0428] L2

[0429]

[0430] R81In some embodiments, Rwis selected from:

[0431] |-ly^R82

[0432]

[0433] In some embodiments, Rwis R82R82.

[0434] L2

[0435] In some embodiments,

[0436]

[0437] Rwis \ R81.

[0438] In some embodiments. L1is -L-C(O)-. -L-NR9C(O)-, -L-S(0)2-, -L-NR9S(O)-, or -L-NR9S(O)2-, or wherein L1is attached to Ring moiety B through the L linking group; L is a bond; and R9is selected from H and C1-6 alkyl.

[0439] In some embodiments, L2is -L-C(O)-, -L-NR9C(O)-, -L-S(0)2-, or -L-NR9S(O)2-, wherein L2is attached to Ring moiety B through the L linking group; L is a bond; and R9is selected from H and C1-6 alkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0440] In some embodiments, L2is -C(O)-, -NR9C(O)-, -S(O)2-, or -NR9S(O)2-; and R9is selected from H and C1-3 alkyl.

[0441] In some embodiments, when L2is -C(O)- or -S(O)2-, then L2is attached to a nitrogen ring member of Ring moiety B.

[0442] In some embodiments, when L2is -C(O)- or -S(O)2- and Ring moiety B is

[0443]

[0444] , then L2is attached to the nitrogen ring member of Cy2.

[0445] In some embodiments, R81, R82, and R83are each independently selected from H, halo, CN, C1-6 alkyl. C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaiyl-C 1-4 alkyl, ORa8, C(O)Rb8, C(O)NRc8Rd8, and C(O)ORa8, wherein said C1-6 alkyl, C1-6 haloalk l. 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C 1-3 haloalkoxy, C1-3 alkoxy carbonyl, amino, C 1-3 alkylamino, di(Ci-3alkyl)amino, and N(CD3)2.

[0446] In some embodiments, R81, R82, and R83are each independently selected from H, D, halo, CN, C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl.

[0447] 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa8, SRa8, NHORa8, C(O)Rb8, C(O)NRc8Rd8, C(O)NRc8(ORa8), C(O)ORa8, OC(O)Rb8, OC(O)NRc8Rd8, NRc8Rd8, NRc8NRc8Rd8, NRc8C(O)Rb8. NRc8C(O)ORa8, NRc8C(O)NRc8Rd8, C(=NRe8)Rb8, C(=NRc8)NRc8Rd8. NRc8C(=NRc8)NRc8Rd8, NRc8C(=NRc8)Rb8, NRc8S(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8, NRc8S(O)(=NRe8)Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8,

[0448]

[0449] S(O)NRc8Rd8, S(O)2Rb8, S(O)2NRc8Rd8, OS(O)(=NRe8)Rb8, OS(O)2Rb8, and S(O)(=NRe8)Rb8, wherein said C1-6 alkyl, C1-6 haloalky l, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by71, 2, 3, or 4 independently selected RGsubstituents.

[0450] In some embodiments, R81, R82, and R83are each independently selected from H, halo, CN, C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl. ORa8, C(O)Rb8, C(O)NRc8Rd8. and C(O)ORa8. wherein said C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-C 1-4 alkyd, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionallyAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0451] substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy. C 1-3 haloalkoxy, C1-3 alkoxy carbonyl, amino, C 1-3 alkylamino, and di(Ci-3 alkyl)amino.

[0452] In some embodiments, n is 0, 1, 2, 3, or 4.

[0453] In some embodiments, n is 0, 1, 2, or 3.

[0454] In some embodiments, p is 0, 1, 2, 3, or 4.

[0455] In some embodiments, p is 0, 1, or 2.

[0456] In some embodiments, X is N.

[0457] In some embodiments, X is CR1.

[0458] In some embodiments, R1is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORbl, SRbl, C(O)Rbl, C(O)NRclRdl, C(O)ORal, OC(O)Rbl, OC(O)NRclRdl, NRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(O)NRclRdl, NRclS(O)2Rbl, NRclS(O)2NRclRdl. S(O)2Rbl, and S(O)2NRclRdl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cy cl oalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents.

[0459] In some embodiments, R1is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents.

[0460] In some embodiments, R1is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalk d, phenyl. 4-7 membered heterocycloalky l, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3. or 4 independently selected R1Asubstituents.

[0461] In some embodiments:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0462] each Ra1, Rc1, and Rd1is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0463] or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R1Asubstituents;

[0464] each Rblis independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0465] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcl lC(O)ORa11, NRcl 1C(O)NRcl lRdn, NRc, 1S(O)2Rbn, NRc11S(O)2NRc11Rd11, S(O)2Rb11, and S(O)2NRcllRd11, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, ph enyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0466] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0467] membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0468] each Rbl1is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0469] each R1Bis independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa12, SRa12, C(O)Rb12, C(O)NRc12Rd12, C(O)ORa12, OC(O)Rb12, OC(O)NRc12Rd12, NRc12Rd12, NRc12C(O)Rb12, NRc12C(O)ORa12, NRcl2C(O)NRc12Rd12, NRc12S(O)2Rb12, NRcl2S(O)2NRc12Rd12, S(O)2Rb12, and S(O)2NRc12Rd12;

[0470] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0471] each Rbl2is independently selected from C1-6 alkyl, and C1-6 haloalkyl.

[0472] In some embodiments:

[0473] each Ral, Rcl, and Rdlis independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0474] or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0475] each Rblis independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0476] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0477] membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C i-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11. SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;

[0478] each Ral1, Rcl1, and Rdl1is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl; and

[0479] each Rbl1is independently selected from Ci-6 alkyl and Ci-6 haloalkyl.

[0480] In some embodiments:

[0481] each Ral, Rcl. and Rdlis independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0482] or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R1Asubstituents;

[0483] each Rblis independently selected from C1-6 alkyd, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0484] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRellRd11, NRellRd11, NRcllC(O)Rb11, NRcllC(O)ORa11. NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;

[0485] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0486] each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0487] In some embodiments, Z is N.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0488] In some embodiments, Z is CR2.

[0489] In some embodiments, R2is selected from H, D. halo. CN, Ci-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORb2, SRb2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2. S(O)2Rb2, and S(O)2NRc2Rd2, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R2Asubstituents.

[0490] In some embodiments, R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R2Asubstituents.

[0491] In some embodiments, R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl. phenyl. 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

[0492] In some embodiments, R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, and C3-5 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

[0493] In some embodiments, R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl.

[0494] In some embodiments, R2is H.

[0495] In some embodiments:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0496] each Ra2, Rc2, and Rd2is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0497] or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R2Asubstituents;

[0498] each Rb2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0499] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, ph enyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;

[0500] each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0501] membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0502] each Rb21is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0503] each R1Bis independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa12, SRa12, C(O)Rb12, C(O)NRc12Rd12, C(O)ORa12, OC(O)Rb12, OC(O)NRc12Rd12, NRc12Rd12, NRc12C(O)Rb12, NRc12C(O)ORa12, NRcl2C(O)NRc12Rd12, NRc12S(O)2Rb12, NRcl2S(O)2NRc12Rd12, S(O)2Rb12, and S(O)2NRc12Rd12; and

[0504] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl.

[0505] In some embodiments:

[0506] each Ra2, Rc2. and Rd2is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0507] or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0508] each Rb2is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0509] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0510] heterocycloalkyl-C t-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa21, SRa21, C(O)Rh21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21. OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0511] each Ra21, Rc21, and Rd21is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl; and

[0512] each Rb21is independently selected from Ci-6 alkyl and Ci-6 haloalkyl.

[0513] In some embodiments:

[0514] each R2Ais independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21. NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0515] each Ra21, Rc21, and Rd21is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl; and

[0516] each Rb21is independently selected from Ci-6 alkyl and Ci-6 haloalkyl.

[0517] In some embodiments, m is 1; s is 1; and Y1is a bond.

[0518] In some embodiments, m is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O).

[0519] In some embodiments, m is 1; s is 1; and Y1is -CR6R60-, -CR6R60-C(O)-. -C(O)-CR6R60-. or C(O).

[0520] In some embodiments, m is 1; s is 1; and Y1is -CR6R60- or C(O).

[0521] In some embodiments, Y1is bound to a nitrogen ring member of Cy1.

[0522] In some embodiments, Cy1is 4-10 membered heterocycloalkyl, which is optionally substituted by 1, 2. 3, or 4 independently selected R10substituents.

[0523] In some embodiments, Cy1is 4-10 membered heterocycloalkyl having 1, 2, or 3 nitrogen ring members, which is optionally substituted by I, 2, 3, or 4 independently selected R10substituents.

[0524] In some embodiments, Cy1is 4-7 membered heterocycloalkyl, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents.

[0525] In some embodiments, Cy1is 4-7 membered heterocycloalkyl having 1 or 2 nitrogen ring members, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0526] In some embodiments, Cy1is an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or an azepine ring, which are each optionally substituted by 1, 2. 3, or 4 independently selected R10substituents.

[0527] In some embodiments, Cy1is an azetidine ring, a pyrrolidine ring, or a piperidine ring, which are each optionally substituted by 1 or 2 independently selected R10substituents.

[0528] In some embodiments, m is 0; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-. or C(O).

[0529] In some embodiments, m is 0; s is 1; and Y1is -CR6R60-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O).

[0530] In some embodiments, m is 0; s is 1; and Y1is -CR6R60- or C(O).

[0531] In some embodiments:

[0532] each R10is independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORal°. SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rd10, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0533] each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0534] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0535] In some embodiments:

[0536] each R10is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°, SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°. OC(O)NRel0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°. NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rd10;

[0537] each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0538] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0539] In some embodiments:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0540] each R6is independently selected from H, D, halo. CN, Ci-6 alky l. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyd, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alk 1 are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents; and each R60is independently selected from H. C1-6 alkyl, and C1-6 haloalkyl;

[0541] or R6and R60, together with the carbon atom to which they are attached, form a 4-10 membered heterocycloalky 1 moiety, which is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents.

[0542] In some embodiments:

[0543] each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6. NRc6Rd6. NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents; and each R60is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0544] or R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety, each of which is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents.

[0545] In some embodiments:

[0546] each R6is independently selected from H, D, halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa6, SRa6, C(O)Rb6, C(O)NRo6Rd6. C(O)ORa6. OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6. NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0547] alkynyl, and Ci-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents; and

[0548] each R60is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0549] or R6and R60, together with the carbon atom to which they are attached, form a 4-10 membered heterocycloalkyl moiety7, which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0550] In some embodiments:

[0551] each R6is independently selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6. wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents; and

[0552] each R60is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0553] or R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0554] In some embodiments, each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C1-6 haloalkyl, and C3-7 cycloalkyl.

[0555] In some embodiments, each R6is independently selected from H, D, halo, CN, C1-6 alkyl, and C1-6 haloalkyl.

[0556] In some embodiments, R6is independently selected from H, D, C1-3 alkyd, and C3-7 cycloalkyl.

[0557] In some embodiments, each R6is independently selected from H, D, and C1-3 alkyl. In some embodiments, each R6is independently selected from H, C1-3 alkyl, and C3-7 cycloalkyd.

[0558] In some embodiments, each R6is independently selected from H and C1-3 alkyd. In some embodiments, each R60is independently selected from H, D and C1-3 alkyl. In some embodiments, each R60is independently selected from H and C1-3 alkyl. In some embodiments, R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety7, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0559] In some embodiments, R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl moiety, which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0560] In some embodiments:

[0561] each Ra6, Rc6, and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0562] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0563] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61, SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc6lC(O)ORa61, NRc61C(O)NRc6lRd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0564] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0565] membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0566] each Rb61is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;

[0567] each R6Bis independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa62. SRa62, C(O)Rb62. C(O)NRc62Rd62, C(O)ORa62, OC(O)Rb62, OC(O)NRc62Rd62, NRc62Rd62, NRc62C(O)Rb62, NRc62C(O)ORa62, NRc62C(O)NRc62Rd62, NRc62S(O)2Rb62, NRc62S(O)2NRc62Rd62, S(O)2Rb62, and S(O)2NRc62Rd62;

[0568] each Ra62, Rc62. and Rd62is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl; and

[0569] each Rb62is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl.

[0570] In some embodiments:

[0571] each Ra6. Rc6. and Rd6is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0572] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0573] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0574] membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C i-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61. SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;

[0575] each Ra61, Rc61, and Rd61is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl; and

[0576] each Rb61is independently selected from Ci-6 alkyl and Ci-6 haloalkyl.

[0577] In some embodiments:

[0578] each Ra6, Rc6. and Rd6is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0579] each Rb6is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, and C2-6 alkynyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0580] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa61, SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61. NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;

[0581] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0582] each Rb61is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0583] In some embodiments, Ring moiety B is phenyl, naphthyl, 5- 10 membered heteroaryl, or 9-12 membered heterocycloalkyl.

[0584] In some embodiments, Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl.

[0585] 9-10 membered heteroaryl, or 9-12 membered heterocycloalkyl.

[0586] In some embodiments, Ring moiety B is phenyl.

[0587] In some embodiments. Ring moiety B is naphthyl.

[0588] In some embodiments, Ring moiety B is 5-6 membered heteroaryl.

[0589] In some embodiments, Ring moiety B is 9-10 membered heteroaryl.

[0590] In some embodiments, Ring moiety B is 9-12 membered heterocycloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0591] | f Ar1J Cy2N — |

[0592] In some embodiments, Ring moiety B is

[0593]

[0594] ' —, wherein Ar1is fused to Cy2, Ar1is bonded to Y, Ar1is pheny l or 5-6 membered heteroary!, and Cy2is 4-8 membered heterocycloalkyl.

[0595] In some embodiments. Ring moiety B is phenyl, naphthyl, 5-6 membered heteroary 1,

[0596] | ( Ar1jcy2N— |

[0597] 9-10 membered heteroaryl, or

[0598]

[0599] ; wherein:

[0600] Ar1is fused to Cy2and Ar1is bonded to Y;

[0601] Ar1is phenyl or 5-6 membered heteroary l; and

[0602] Cy2is 4-8 membered heterocycloalkyl.

[0603] In some embodiments, R3is selected from H, D. halo. CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-5 cycloalkyl, ORa3, SRa3, NHORa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3.

[0604] In some embodiments, each Ra3, Rc3, and Rd3is independently selected from H. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl; and each Rb3is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl.

[0605] In some embodiments, R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 1-6 haloalkyl, ORa3, and NRc3Rd3.

[0606] In some embodiments, R3is selected from H, D. halo. CN, C1-6 alkyl, C2-6 alkenyl, C2- 6 alkynyl, and Ci-6haloalkyl.

[0607] In some embodiments, R3is H.

[0608] In some embodiments, each Ra3, Rc3, and Rd3is independently selected from H and Ci-6 alkyl.

[0609] In some embodiments, R4is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6haloalkyl, C3-5 cycloalkyl, ORa4, SRa4, NHORa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, NRc4S(O)2Rb4. NRc4S(O)2NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4

[0610] In some embodiments, each Ra4. Rc4, and Rd4is independently selected from H. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl; and each Rb4is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl.

[0611] In some embodiments, R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl. and C 1-6 haloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0612] In some embodiments, R4is selected from H.

[0613] In some embodiments, Ring moiety A is 6-10 membered aryl or 5-10 membered heteroaryl.

[0614] In some embodiments, Ring moiety A is phenyl or 5-10 membered heteroaryl.

[0615] In some embodiments, Ring moiety7A is phenyl, 5-6 membered heteroaryl, and 9-10 membered heteroaryl.

[0616] In some embodiments. Ring moiety A is 6-10 membered aryl.

[0617] In some embodiments, Ring moiety A is phenyl.

[0618] In some embodiments, Ring moiety A is 5-10 membered heteroaryl.

[0619] In some embodiments, Ring moiety A is 5-6 membered heteroaryl or 9-10 membered heteroaryl.

[0620] In some embodiments, Ring moiety A is 5-6 membered heteroaryl.

[0621] In some embodiments, Ring moiety A is 9-10 membered heteroaryl.

[0622] In some embodiments, each R5is independently selected from D, halo, CN, C i-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa5, SRa5, NHORa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5. NRc5C(O)NRc5Rd5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

[0623] In some embodiments, each R5is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa5and NRc3Rd5, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

[0624] In some embodiments:

[0625] each RaRc5, and Rd3is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0626] membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C i-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0627] each Rh3is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl which are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents; and

[0628] each R5Ais independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalky l, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl. C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino. thio, Ci-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C 1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy. C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(C 1-3 alky l)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0629] In some embodiments:

[0630] each Ra5, Rc5. and Rd5is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-4 cycloalkyl, and 4-5 membered heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-4 cycloalkyl, and 4-5 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0631] each Rb5is independently selected from C1-6 alkyl, C1-6 haloalkyl. C2-6 alkenyl, C2-6 alkynyl, C3-4 cycloalkyl, and 4-5 membered heterocycloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents; and

[0632] each R5Ais independently selected from OH, CN, halo, C1-3 alkyd, C1-3 haloalkyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino.

[0633] In some embodiments, each R5is independently selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, and C1-3 haloalkoxy.

[0634] In some embodiments, each R5is independently selected from Cl, F, CN, CH3, OH, and OCH3.

[0635] In some embodiments, each R7is independently selected from D, halo, CN. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0636] membered heterocycloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)2Rb7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Ci-4 alkylidene-C?-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl -C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents.

[0637] In some embodiments, each R7is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-Cs-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)2Rb7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl. Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C.3-7Cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alky l, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0638] In some embodiments, each R7is independently selected from halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-Cs-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, and NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Ci-4 alkylidene-C3-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0639] In some embodiments:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0640] each Ra7, Rc7, and Rd7is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0641] each Rb7is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cy cloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0642] each R7Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa71, SRa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, OC(O)Rb71, OC(O)NRc71Rd71, NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, NRc71S(O)2Rb71, NRc71S(O)2NRc71Rd71, S(O)2Rb71. and S(O)2NRc71Rd71. wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0643] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0644] each Rb71is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0645] C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and

[0646] each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino. thio, Ci-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxycarbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy. C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino. and di(Ci-3 alkyl)aminocarbonylamino.

[0647] In some embodiments:

[0648] each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0649] each Rb7is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0650] each R7Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa71, C(O)Rb71. C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;

[0651] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0652] each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0653] In some embodiments:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0654] each Ra7, Rc7, and Rd7is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl, wherein said Ci-6 alkyl and Ci-6 haloalkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents;

[0655] each Rh7is independently selected from Ci-6 alkyl and Ci-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0656] each R7Ais independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, ORa71. C(O)Rb71, C(O)NRc71Rd71. C(O)ORa71, and NRc71Rd71;

[0657] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0658] or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and

[0659] each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalky l, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino.

[0660] In some embodiments:

[0661] n is 0, 1, 2, 3, or 4;

[0662] p is 0, 1, 2, 3, or 4;

[0663] r is 1 or 2;

[0664] m is 1; s is 1; andY1is a bond: or

[0665] m is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); or m is 0; s is 1; andY1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O);

[0666] Cy1is 4-10 membered heterocycloalkyl having 1, 2, or 3 nitrogen ring members, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents;

[0667] Ring moiety A is phenyl or 5-10 membered heteroaryl;

[0668] Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl. 9-10 membered

[0669] heteroaryl, o

[0670]

[0671] r;

[0672] Ar1is fused to Cy2and Ar1is bonded to Y;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0673] Ar1is phenyl or 5-6 membered heteroaryl;

[0674] Cy2is 4-8 membered heterocycloalkyl;

[0675] X is N or CR1;

[0676] Z is N or CR2;

[0677] R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORbl, SRbl, C(O)Rbl, C(O)NRclRdl, C(O)ORal, OC(O)Rbl, OC(O)NRclRdl, NRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(O)NRclRdl, NRclS(O)2Rbl, NRclS(O)2NRclRdl, S(O)2Rbl, and S(O)2NRclRdl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0678] each Ral, Rcl. and Rdlis independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0679] or, any Rc1and Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0680] each Rblis independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0681] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0682] heterocycloalkyl-C t-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0683] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyd, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0684] each Rb11is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroary l, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0685] each R1Bis independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa12, SRa12, C(O)Rb12, C(O)NRc12Rd12, C(O)ORa12, OC(O)Rb12, OC(O)NRc12Rd12, NRc12Rd12, NRcl2C(O)Rb12, NRc12C(O)ORa12. NRcl2C(O)NRc12Rd12, NRcl2S(O)2Rb12, NRcl2S(O)2NRc12Rd12, S(O)2Rb12, and S(O)2NRc12Rd12;

[0686] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0687] each Rbl2is independently selected from C1-6 alkyl, and C1-6 haloalkyl;

[0688] R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky 4, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalky l, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroary l are each optionally substituted with 1, 2. 3, or 4 independently selected R2Asubstituents.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0689] each Ra2, Rc2, and Rd2is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0690] or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R2Asubstituents;

[0691] each Rb2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0692] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0693] each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0694] each Rb21is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0695] R3is selected from H, D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-5 cycloalkyl, ORa3. SRa3. NHORa3. C(O)Rb3. C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3;

[0696] each Ra3, Rc3. and Rd3is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0697] each Rb3is independently selected from Ci-6 alky l, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0698] R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-5 cycloalkyl, ORa4, SRa4, NHORa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4;

[0699] each Ra4, Rc4. and Rd4is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0700] each Rb4is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0701] each R5is independently selected from D, halo, CN. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa5and NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky 1, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0702] each Ra5, Rc5. and Rd5is independently selected from H. C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0703] each R5Ais independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino. C1-3 alkylamino, di(Ci-3 alkyl)amino. thio, Ci-3 alkylthio, C1-3 alkylsulfmyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C 1-3 alky Icarbonyl, C 1-3 alkoxy carbonyl, C 1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(C 1-3 alky l)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino;

[0704] each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl. C1-6 haloalkyl, C3-7 cycloalky 1. phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0705] alky l, 4-7 membered heterocycloalkyl-C i-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1. 2, 3, or 4 independently selected R6Asubstituents;

[0706] each R60is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0707] or R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety, each of which are optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents;

[0708] each Ra6, Rc6. and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0709] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalkyl. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0710] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa61, SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61. OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;

[0711] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0712] each Rb61is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0713] each R7is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0714] OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)2Rb7, and S(O)2NRc7Rd7, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, Ci-4 alkylidene-C3-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0715] each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents;

[0716] each Rb7is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0717] each R7Ais independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa71. SRa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, OC(O)Rb71, OC(O)NRc71Rd71, NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, NRc71S(O)2Rb71, NRc71S(O)2NRc71Rd71, S(O)2Rb71, and S(O)2NRc71Rd71, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0718] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0719] heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0720] each Rb71is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0721] each R7Bis independently selected from D, OH. CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, thio, Ci-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxycarbonyl. C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino;

[0722] Rwis selected from:

[0723] I— 1_2R82 I — L2R82I — L2R82?^Cl / ^Br. R82R82. R82C(O)R83;R82S(O)tR83and

[0724]

[0725] L1is -L-C(O)-. -L-NR9C(O)-, -L-S(O)2-, -L-NR9S(O)-, or -L-NR9S(O)2-. or wherein L1is attached to Ring moiety B through the L linking group;

[0726] L2is -L-C(O)-, -L-NR9C(O)-, -L-S(O)2-, or -L-NR9S(O)2-, wherein L2is attached to Ring moiety B through the L linking group;

[0727] Lis a bond:

[0728] R9is selected from H and C1-6 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0729] R81, R82, and R83are each independently selected from H, D, halo, CN, Ci-6 alkyl, Ci-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa8, SRa8, NHORa8, C(O)Rb8, C(O)NRc8Rd8, C(O)NRc8(ORa8), C(O)ORa8, OC(O)Rb8, OC(O)NRc8Rd8, NRc8Rd8, NRc8NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8. NRc8C(O)NRc8Rd8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, NRc8C(=NRe8)NRc8Rd8, NRc8C(=NRe8)Rb8, NRc8S(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8. NRc8S(O)(=NRe8)Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, S(O)2NRc8Rd8,

[0730]

[0731] OS(O)(=NRe8)Rb8, OS(O)2Rb8, and S(O)(=NRe8)Rb8, wherein said C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;

[0732] each Ra8, Rc8, and Rd8is independently selected from H and C1-6 alkyl;

[0733] each R10is independently selected from D. halo. CN, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa10, SRa10, C(O)Rb10, C(O)NRc10Rd10, C(O)ORa10, OC(O)Rb10, OC(O)NRc10Rd10, NRc10Rd10, NRc10C(O)Rb10, NRc10C(O)ORa10, NRc10C(O)NRc10Rd10, NRc10S(O)2Rb10, NRc10S(O)2NRc10Rd10, S(O)2Rb10, and S(O)2NRc10Rd10;

[0734] each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0735] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl; and each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alky l, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino. C1-3 alkylamino, di(Ci-3 alkyl)amino, N(CDs)2, thio, C 1-3 alkylthio, C 1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(C 1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0736] In some embodiments:

[0737] n is 0, 1, 2, 3. or 4;

[0738] p is 0, 1, 2, 3, or 4;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0739] r is 1 or 2;

[0740] m is 1; s is 1; andY1is a bond: or

[0741] m is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); or m

[0742]

[0743] is 0; s is 1; andY1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or CCO^Cy1is 4-10 membered heterocycloalkyl having 1, 2, or 3 nitrogen ring members, which is optionally substituted by 1, 2. 3, or 4 independently selected R10substituents;

[0744] Ring moiety A is phenyl or 5-10 membered heteroaryl;

[0745] Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl. 9-10 membered

[0746] heteroaryl, o

[0747]

[0748] r

[0749] Ar1is fused to Cy2and Ar1is bonded to Y;

[0750] Ar1is phenyl or 5-6 membered heteroaryl;

[0751] Cy2is 4-8 membered heterocycloalkyl;

[0752] X is N or CR1;

[0753] Z is N or CR2;

[0754] R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORbl, SRbl, C(O)Rbl, C(O)NRclRdl, C(O)ORal, OC(O)Rbl, OC(O)NRclRdl, NRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(0)NRclRdl, NRclS(O)2Rbl, NRclS(O)2NRclRdl, S(O)2Rbl, and S(O)2NRclRdl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0755] each Ral, Rcl. and Rdlis independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0756] or, any Rc1and Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0757] each Rblis independently selected from Ci-6 alky l, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0758] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0759] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;

[0760] each Rbl1is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0761] each R1Ris independently selected from D, halo, CN, Ci-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa12, SRa12, C(O)Rb12, C(O)NRc12Rd12, C(O)ORa12, OC(O)Rb12. OC(O)NRc12Rd12, NRc12Rd12, NRcl2C(O)Rb12, NRc12C(O)ORa12, NRcl2C(O)NRc12Rd12, NRcl2S(O)2Rb12, NRcl2S(O)2NRc12Rd12, S(O)2Rb12, and S(O)2NRc12Rd12;

[0762] each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0763] each Rbl2is independently selected from C1-6 alkyl, and C1-6 haloalkyl;

[0764] R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

[0765] each Ra2, Rc2, and Rd2is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R2Asubstituents;

[0766] or, any Rc2and Rd2attached to the same N atom, together wi th the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0767] each Rb2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0768] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa21. SRa21, C(O)Rb21. C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0769] NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0770] each Ra21, Rc21, and Rd21is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0771] each Rb21is independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0772] R3is selected from H, D. halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, C3-5 cycloalkyl, ORa3. SRa3. NHOR13, C(O)Rh3. C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3;

[0773] each Ra3, Rc3. and Rd3is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0774] each Rb3is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0775] R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-5 cycloalkyl, ORa4, SRa4, NHORa4. C(O)Rb4. C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4;

[0776] each Ra4, Rc4, and Rd4is independently selected from H, C 1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0777] each Rb4is independently selected from C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, and C1-6 haloalkyl;

[0778] each R5is independently selected from D, halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa5and NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R5Asubstituents;

[0779] each Ra3, Rc5, and Rd3is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalky l are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0780] each R5Ais independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, thio, Ci-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxycarbonyl. C 1-3 alkylcarbonyloxy. C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0781] alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(C 1-3 alky l)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkydaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino;

[0782] each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0783] each R60is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0784] or R6and R60, together with the carbon atom to which they are attached, form a 4-10 membered heterocycloalkyl moiety, which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

[0785] each Ra6, Rc6, and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0786] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0787] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61, SRa61, C(O)Rb61,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0788] C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61. OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rh61, NRc61S(O)2NRc61Rd61, S(O)2Rb61. and S(O)2NRc61Rd61;

[0789] each Ra61, Rc61, and Rd61is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0790] each Rb61is independently selected from Ci-s alkyl and Ci-6 haloalkyl.

[0791] each R7IS independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, Ci-4 alkylidene-Cs-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl. ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7. C(O)ORa7. OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)2Rb7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alky lidene-Cs-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0792] each Ra7, Rc7. and Rd7is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0793] each Rb7is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0794] each R7Ais independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0795] heterocycloalkyl-C t-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa71, SRa71, C(O)Rh71, C(O)NRc71Rd71, C(O)ORa71, OC(O)Rb71. OC(O)NRc71Rd71, NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, NRc71S(O)2Rb71, NRc71S(O)2NRc71Rd71, S(O)2Rb71, and S(O)2NRc71Rd71, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky 1, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0796] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyd, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0797] each Rb71is independently selected from C1-6 alkyd, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cy cloalky 1, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroary l, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0798] each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkyny l, C1-3 haloalky 1, cyano-Ci-3 alkyd, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyd. C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino. thio, Ci-3 alkydthio, C1-3 alkylsulfinyl, C1-3 alkylsulfony 1, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkydcarbonyl, C 1-3 alkoxy carbonyl, C 1-3 alkylcarbonyloxy, C1-3 alky lcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkydaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino;

[0799] Rwis selected from:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0800] R82R82S(O)tR885 andL2

[0801]

[0802] R81• L1is -L-C(O)-, -L-NR9C(O)-, -L-S(O)2-, -L-NR9S(O)-, or -L-NR9S(O)2-, or wherein L1is atached to Ring moiety' B through the L linking group;

[0803] L2is -L-C(O)-, -L-NR9C(O)-, -L-S(O)2-, or -L-NR9S(O)2-, wherein L2is atached to Ring moiety B through the L linking group;

[0804] Lis a bond;

[0805] R9is selected from H and Ci-6 alkyl;

[0806] R81, R82, and R83are each independently selected from H, D, halo, CN, Ci-6 alkyl, Ci-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaiyl-C 1-4 alkyl, ORa8, SRa8, NHORa8, C(O)Rb8, C(O)NRc8Rd8, C(O)NRc8(ORa8), C(O)ORa8, OC(O)Rb8, OC(O)NRc8Rd8, NRc8Rd8, NRc8NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8. NRc8C(O)NRc8Rd8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, NRc8C(=NRe8)NRc8Rd8, NRc8C(=NRe8)Rb8, NRc8S(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8, NRc8S(O)(=NRe8)Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, S(O)2NRc8Rd8, OS(O)(=NRe8)Rb8, OS(O)2Rb8, and S(O)(=NRe8)Rb8, wherein said C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;

[0807] each Ra8, Rc8. and Rd8is independently selected from H and Cr-6 alkyl;

[0808] each R10is independently selected from D. halo. CN, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa10, SRa10, C(O)Rb10, C(O)NRc10Rd10, C(O)ORa10, OC(O)Rb10, OC(O)NRc10Rd10, NRc10Rd10, NRc10C(O)Rb10, NRc10C(O)ORa10, NRc10C(O)NRc10Rd10, NRc10S(O)2Rb10, NRc10S(O)2NRc10Rd10, S(O)2Rb10, and S(O)2NRc10Rd10;

[0809] each Ral°, Rcl°. and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0810] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl; andAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0811] each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl. cyano-Ci-3 alkyl. HO-C1-3 alkyl. C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, thio, C 1-3 alkylthio, C 1-3 alky Isulfinyl, C 1-3 alkylsulfonyl, carbamyl, C 1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C 1-3 alky lcarbonyl, C1-3 alkoxycarbonyl, C 1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino. C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, Ci-3alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-s alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkydaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0812] In some embodiments;

[0813] n is 0, 1, 2, 3. or 4;

[0814] p is 0, 1, 2, 3, or 4;

[0815] m is 1; s is 1; and Y1is a bond; or

[0816] m is 1; s is 1; andY1is -CR6R60-, -(CR6R60)2-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(0); or

[0817] m is 0; s is 1; and Y1is -CR6R60-, -(CR6R60)2-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O);

[0818] Cy1is 4-7 membered heterocycloalkyl having 1 or 2 nitrogen ring members, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents;

[0819] Ring moiety A is phenyl. 5-6 membered heteroaryl, or 9-10 membered heteroaryl; Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl. 9-10 membered

[0820] heteroaryl, o

[0821]

[0822] r

[0823] Ar1is fused to Cy2and Ar1is bonded to Y;

[0824] Ar1is phenyl or 5-6 membered heteroaryl;

[0825] Cy2is 4-8 membered heterocycloalkyl;

[0826] X is N or CR1;

[0827] Z is N or CR2;

[0828] R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky 1, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0829] C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected R1Asubstituents;

[0830] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;

[0831] each Ral1, Rcl1. and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0832] each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0833] R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0834] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21. OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21. NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0835] each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0836] each Rb21is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0837] R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, ORaa, and NRc3Rd3;

[0838] each Ra3, Rc3, and Rd3is independently selected from H and C1-6 alkyl;

[0839] R4is selected from H, D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0840] R3is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-4 cycloalkyl, ORa5and NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0841] each Ra5, Rc5, and Rd5is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-4 cycloalkyl, and 4-5 membered heterocycloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0842] each R5Ais independently selected from OH, CN, halo, C1-3 alkyl, C1-3 haloalkyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;

[0843] each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, ORa6, SRa6. C(O)Rb6. C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0844] each R60is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0845] or R6and R60, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl or a 4-7 membered heterocycloalkyl moiety', each of which are optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents;

[0846] each Ra6, Rc6, and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalk l are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0847] each Rb6is independently selected from C1-6 alkyl, C1-6 haloalkyl. C2-6 alkenyl, and C2-6 alkynyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0848] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa61, SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61. OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;

[0849] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0850] each Rb61is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0851] each R7is independently selected from halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7. C(O)Rb7. C(O)NRc7Rd7, C(O)ORa7, and NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0852] membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0853] each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0854] each Rb7is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0855] each R7Ais independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaiyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;

[0856] each Ra71, Rc71. and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0857] each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0858] Rwis selected from:

[0859]

[0860] L2is -C(O)-, -NR9C(O)-, -S(O)2-, or -NR9S(O)2-;

[0861] provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1;

[0862] R9is selected from H and C1-3 alkyl;

[0863] R81and R82are each independently selected from H, halo, CN, C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaiyl-Ci-4 alkyl, ORa8, C(O)Rb8. C(O)NRc8Rd8, and C(O)ORa8, wherein saidAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0864] Ci-6 alkyl, Ci-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxy carbonyl, amino, C1-3 alkylamino, and di(C 1-3 alkyl)amino;

[0865] each Ra8, Rc8, and Rd8is independently selected from H and C1-6 alkyl;

[0866] each R10is independently selected from D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°. SRal°, C(O)Rbl°. C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°. OC(O)NRcl0Rdl(), NRcl0Rdl(), NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rd10, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rdl°;

[0867] each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0868] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl; and each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alky l, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alky l, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino. C1-3 alkylamino, di(Ci-3 alkyl)amino, N(CDS)2, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy, C 1-3 alkylcarbonylamino, C 1-3 alkoxy carbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino. C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

[0869] In some embodiments:

[0870] n is 0, 1, 2, 3. or 4;

[0871] p is 0, 1, 2, 3, or 4;

[0872] m is 1; s is 1; and Y1is a bond; or

[0873] m is 1; s is 1; and Y1is -CR6R60-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); or m is 0; s is 1; and Y1is -CR6R60-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); Cy1is 4-7 membered heterocycloalkyl having 1 or 2 nitrogen ring members, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents;

[0874] Ring moiety A is phenyl, 5-6 membered heteroaryl, or 9-10 membered heteroary l;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0875] Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl, 9-10 membered

[0876] heteroaryl, o

[0877]

[0878] r

[0879] Ar1is fused to Cy2and Ar1is bonded to Y;

[0880] Ar1is phenyl or 5-6 membered heteroaryl;

[0881] Cy2is 4-8 membered heterocycloalkyl;

[0882] X is N or CR1;

[0883] Z is N or CR2;

[0884] R1is selected from H, D. halo. CN, Ci-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0885] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyd, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rh11, NRcllS(O)2NRcllRd11, S(O)2Rb11. and S(O)2NRcllRd11;

[0886] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0887] each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0888] R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;

[0889] each R2Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0890] OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;

[0891] each Ra21, Rc21, and Rd21is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0892] each Rb21is independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0893] R3is selected from H, D. halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and Ci-6 haloalkyl;

[0894] R4is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and Ci-6 haloalkyl;

[0895] R5is independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, C3-4 cycloalkyl. ORa5and NRc5Rd5. wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0896] each Ra5, Rc5, and Rd5is independently selected from C1-6 alkyd, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-4 cycloalkyl, and 4-5 membered heterocycloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;

[0897] each R5Ais independently selected from OH, CN, halo, C1-3 alkyl, C1-3 haloalkyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;

[0898] each R6is independently selected from H, D, halo, CN, C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6. C(O)ORa6. OC(O)Rb6.

[0899] OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently- selected R6Asubstituents;

[0900] each R60is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0901] or R6and R60, together with the carbon atom to which they are attached, form a 4-10 membered heterocycloalkyl moiety-, which is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;

[0902] each Ra6, Rc6. and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0903] each Rb6is independently selected from Ci-6 alky l, Ci-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;

[0904] each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa61, SRa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61. NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;

[0905] each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0906] each Rb61is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0907] each R7is independently selected from halo. CN, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, ORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, andNRc7Rd7, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Ci-4 alky lidene-C'3-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0908] each Ra7, Rc7. and Rd7is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyd, 5-6 membered heteroary 1-C 1-4 alkyd, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0909] each Rb7is independently selected from C1-6 alkyd, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroary 1-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0910] each R7Ais independently selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0911] each Ra71, Rc71, and Rd71is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;

[0912] each Rb71is independently selected from Ci-6 alkyl and Ci-6 haloalkyl;

[0913] Rwis selected from:

[0914] j— L2R82 5\\

[0915]

[0916] R82R82and R81;

[0917] L2is -C(O)-, -NR9C(O)-. -S(O)2-, or -NR9S(O)2-;

[0918] provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1;

[0919] R9is selected fromH and C1-3 alkyl;

[0920] R81and R82are each independently selected from H, halo. CN, C1-6 alkyl. C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa8, C(O)Rb8, C(O)NRc8Rd8, and C(O)ORa8, wherein said C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;

[0921] each Ra8, Rc8, and Rd8is independently selected from H and C1-6 alkyl;

[0922] each R10is independently selected from D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°. SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°. OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rdl°;

[0923] each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0924] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl; and each RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alky l, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alky l, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, thio, C 1-3 alkylthio, C 1-3 alky Isulfinyl, C 1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(Ci-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxycarbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(C 1-3 alky l)aminosulfonyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0925] aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkydaminocarbonylamino, and di(Ci-3 alky l)aminocarbonylamino.

[0926] In some embodiments:

[0927] n is 0, 1, 2, 3, or 4;

[0928] p is 0, 1, 2, 3, or 4;

[0929] m is 1; s is 1; andY1is a bond: or

[0930] m is 1; s is 1; and Y1is -CR6R60-, -(CR6R60)2-, or C(O); or

[0931] m is 0; s is 1; andY1is -CR6R60-, -(CR6R60)2-, or C(O); Cy1is an azetidine ring, a pyrrolidine ring, or a piperidine ring, which are each optionally substituted by 1 or 2 independently selected R10substituents;

[0932] Ring moiety A is phenyl. 5-6 membered heteroaryl, or 9-10 membered heteroaryl; Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl, 9-10 membered

[0933] heteroaryl, o

[0934]

[0935] r

[0936] Ar1is fused to Cy2and Ar1is bonded to Y;

[0937] Ar1is phenyl or 5-6 membered heteroaryl;

[0938] Cy2is 4-8 membered heterocycloalkyl;

[0939] X is N or CR1;

[0940] Z is N or CR2;

[0941] R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0942] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRellRd11, NRellRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rbn, and S(O)2NRcllRdn;

[0943] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0944] each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0945] R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0946] R3is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0947] R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0948] each R5is independently selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, and C1-3 haloalkoxy;

[0949] each R6IS independently selected from H, D, halo, CN, C1-6 alkyl, and C1-6 haloalkyl; each R60is independently selected from H and C1-3 alkyl;

[0950] or R6and R60, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl moiety optionally substituted with 1 or 2 independently selected R7Asubstituents;

[0951] each R7is independently selected from halo. CN, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, andNRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Ci-4 alkylidene-C3-7 cycloalkyl, Ci-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0952] each Ra7, Rc7. and Rd7is independently selected from H. C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R7Asubstituents;

[0953] each Rb7is independently selected from C1-6 alkyd and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0954] each R7Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, andNRc71Rd71;

[0955] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalky l are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0956] or, any Re71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[0957] each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; andAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0958] each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(C 1-3 alkyl)amino;

[0959] Rwis selected from:

[0960] j— L2R82 5\\

[0961]

[0962] R82R82and R81:

[0963] L2is -C(O)-, -NR9C(O)-. -S(O)2-, or -NR9S(O)2-;

[0964] provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1;

[0965] R9is selected fromH and C1-3 alkyl;

[0966] R81and R82are each independently selected from H, halo. CN, C1-6 alkyl. C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, and C(O)ORa8, wherein said C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;

[0967] each Ra8is independently selected from H and C1-6 alkyl; and

[0968] each R10is independently selected from D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°. SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°. OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rdl°;

[0969] each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[0970] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[0971] In some embodiments:

[0972] n is 0, 1, 2, 3. or 4;

[0973] p is 0, 1, 2, 3, or 4;

[0974] m is 1; s is 1; and Y1is a bond; or

[0975] m is 1; s is 1; and Y1is -CR6R60- or C(O); or

[0976] m is 0; s is 1; and Y1is -CR6R60- or C(O); Cy' is an azetidine ring, a pyrrolidine ring, or a piperidine ring, which are each optionally substituted by 1 or 2 independently selected R10substituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0977] Ring moiety' A is phenyl, 5-6 membered heteroaryl, or 9-10 membered heteroaryl; Ring moiety B is phenyl, naphthyl. 5-6 membered heteroaryl, 9-10 membered

[0978] heteroaryl, o

[0979]

[0980] r

[0981] Ar1is fused to Cy2and Ar1is bonded to Y;

[0982] Ar1is phenyl or 5-6 membered heteroaryl;

[0983] Cy2is 4-8 membered heterocycloalkyl;

[0984] X is N or CR1;

[0985] Z is N or CR2;

[0986] R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;

[0987] each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NR011Rd11, NRcllC(O)Rb11, NRcllC(O)ORa11. NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;

[0988] each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;

[0989] each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl;

[0990] R2is selected from H, D. halo. CN, C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0991] R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, and C1-6 haloalkyl;

[0992] R4is selected from H, D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;

[0993] each R5is independently selected from halo, CN, C1-3 alkyd, C1-3 haloalkyl, OH, C1-3 alkoxy, and C1-3 haloalkoxy;

[0994] each R6is independently selected from H, D, halo, CN, C1-6 alky l, and C1-6 haloalky l; each R60is independently selected from H and C1-3 alkyl;

[0995] each R7is independently selected from halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alky didene-4-7-memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[0996] heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7. C(O)Rb7. C(O)NRc7Rd7, C(O)ORa7, and NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0997] each Ra7, Rc7. and Rd7is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;

[0998] each Rb7is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3. or 4 independently selected R7Asubstituents;

[0999] each R7Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;

[1000] each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1. 2, 3, or 4 independently selected R7Bsubstituents;

[1001] or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;

[1002] each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalky l, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(C 1-3 alkyl)amino;

[1003] Rwis selected from:

[1004] f— L2R82 i\\

[1005]

[1006] R82R82and R81:

[1007] L2is -C(O)-, -NR9C(O)-. -S(O)2-, or -NR9S(O)2-;

[1008] provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1;

[1009] R9is selected fromH and C1-3 alkyl;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1010] R81and R82are each independently selected from H, halo, CN, Ci-6 alky l, Ci-6 haloalkyl, 5-6 membered heteroaryl. 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, and C(O)ORa8, wherein said Ci-6 alkyl, Ci-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alky l, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, Ci-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino, C1-3 alkylamino, and di(C 1-3 alkyl)amino;

[1011] each Ra8is independently selected from H and C1-6 alkyl; and

[1012] each R10is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°, SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°. NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rdl°;

[1013] each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and

[1014] each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl.

[1015] In some embodiments:

[1016] ? is X3X2, wherein X1and X2are each independently Cl or F, and X3is H, Cl or F; or

[1017] N

[1018] , wherein X1and X2are each independently Cl, F, OH, and O

[1019]

[1020] CH3; and X3is H, Cl, or F.

[1021] , wherein X1and X2are

[1022]

[1023] Il lAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1024]

[1025] Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1026] In some embodiments,

[1027] (R13)k1

[1028]

[1029] X1is Cl, F, or OCH3;

[1030] X2is H, Cl, or F;

[1031] X3is H, Cl or F;

[1032] R11is OH or CN;

[1033] kl is 0, 1, or 2;

[1034] k2 is 2;

[1035] two R12substituents, together with the carbon atoms to which they are attached, form a pyrazole, pyrrole, or pyrimidine ring, which is optionally substituted by 1 or 2 independently selected R5substituents selected from halo, CN, and C1-3 alkyl; and

[1036] each R13is independently selected from halo, CN, C1-3 alkyl, and C1-3 alkoxy.

[1037] In some embodiments.

[1038]

[1039] X1is Cl, F. or OCH3;

[1040] X2is H, Cl, or F;

[1041] X3is H, Cl or F;

[1042] R11is OH or CN;

[1043] kl is 0, 1, or 2;

[1044] k2 is 2;

[1045] two R12substituents, together with the carbon atoms to which they are attached, form a pyrazole, pyrrole, or pyrimidine ring, which is optionally substituted by 1 or 2 independently selected R5substituents selected from halo, CN, and C1-3 alkyl; and

[1046] each R13is independently selected from halo, CN, and C1-3 alkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1047] In some embodiments, the compound is a compound of Formula (II):

[1048]

[1049] or a pharmaceutically acceptable salt thereof; and wherein Ring moiety A, ring moiety B, Y, R3. R4, R5, R7, Rw. n, and p are as defined according to any other embodiment described herein.

[1050] In some embodiments, the compound is a compound of Formula (III):

[1051]

[1052] or a pharmaceutically acceptable salt thereof; and wherein Ring moiety' A, ring moiety' B, Y, R1, R3, R4, R5, R7, Rw, n, and p are as defined according to any other embodiment described herein.

[1053] In some embodiments, the compound is a compound of Formula (IV):

[1054]

[1055] or a pharmaceutically acceptable salt thereof; and wherein Ring moiety7A, ring moietys B, Y, R2, R3, R4, R '. R7, Rw, n, and p are as defined according to any other embodiment described herein.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1056] In some embodiments, the compound is a compound of Formula (V):

[1057]

[1058] or a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; v is 0 or 1; and Ring moiety A, ring moiety B, Y1, R3, R4, R5, R7, Rw, n, and p are as defined according to any other embodiment described herein.

[1059] In some embodiments, the compound is a compound of Formula (VI):

[1060]

[1061] or a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; v is 0 or 1; and Ring moiety A, ring moiety B, Y1, R1, R3, R4. R5. R7. R n, and p are as defined according to any other embodiment described herein.

[1062] In some embodiments, the compound is a compound of Formula (VII):Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1063]

[1064] or a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; v is 0 or 1; and Ring moiety A, ring moiety B, Y1, R2, R3, R4. R5. R7. R1*, n, and p are as defined according to any other embodiment described herein.

[1065] In some embodiments, the compound is selected from:

[1066] N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)azetidine-l-carbonyl)phenyl)acrylamide;

[1067] (S)-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)pyrrolidine- 1 -carbonyl)phenyl)acrylamide;

[1068] rac-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-y l)piperidine- 1 -carbonyl)phenyl)acrylamide;

[1069] rac-N-(4-((2R,4S)-4-(7-(3.5-dichloro-4-hydroxyphenyl)-2H-[1.2.3]triazolo[4,5-c]pyridin-2-yl)-2-methylpyrrolidine-l-carbonyl)phenyl)acrylamide;

[1070] (S)-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-y l)py rrolidine- 1 -carbonyl)-2-methoxyphenyl)acrylamide;

[1071] rac-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-3-(l-methyl-2-oxo-1.2-dihydropyridin-4-yl)-2H-pyrazolo|4,3-c]pyridin-2-yl)pyrrolidine-l-carbonyl)phenyl)acrylamide;

[1072] N-(4-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)phenyl)acrylamide;

[1073] l-(5-((7-(3.5-dichloro-4-hydroxyphenyl)-2H-[1.2.3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;

[1074] rac-l-(5-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)isoindolin-2-yl)prop-2-en-l-one;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1075] l-(5-((4-(3,5-dichloro-4-hydroxyphenyl)-2H-pyrazolo[3,4-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;

[1076] l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-pyrazolo[4,3-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;

[1077] (£)-2-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindoline-2-carbonyl)-4-methylpent-2-enenitrile;

[1078] l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[L23]triazolo[4,5-c]pyridin-2-yl)methy l)isoindolin-2-y l)but-2-yn- 1 -one;

[1079] l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-2-fluoroprop-2-en-l-one;

[1080] (E)-l-(5-((7-(3?5-dichloro-4-hydroxyphenyl)-2 / 7-[1.2.3]triazolo[4,5-c|pyri din-2-yl)methyl)isoindolin-2-yl)-4-(17 / -l,2,4-triazol-l-yl)but-2-en-l-one;

[1081] (E)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2£7-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-3-(pyridin-4-yl)prop-2-en-l-one;

[1082] (E)-l-(5-((7-(3?5-dichloro-4-hydroxyphenyl)-27f-[1.2.3]triazolo[4,5-c]pyri din-2-y l)methy l)isoindolin-2-y l)-4,4,4-trifluorobut-2-en- 1 -one;

[1083] (£)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-y l)methy l)isoindolin-2-yl)-4-hy droxybut-2-en- 1 -one;

[1084] methyl (E)-4-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-4-oxobut-2-enoate;

[1085] (£')-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2 / f-pyrazolo[4,3-c]pyridin-2-yl)methyl)isoindolin-2-yl)-4,4-difluorobut-2-en-l-one;

[1086] (EJ-4-(azetidin-l-yl)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)but-2-en-l-one:

[1087] l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)prop-2-en-l-one;

[1088] (EJ-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5.7-dihydro-677-pyrrolo[3,4-6]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;

[1089] (^-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2 / / -[L23]triazolo[4,5-c]pyri din-2-yl)methyl)-5,7-dihydro-6 7-pyrrolo[3,4-6]pyridin-6-yl)-4-(piperidin-l-yl)but-2-en-l-one; l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyri din-2-yl)methyl)-5.7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)prop-2-en-l-one; and

[1090] (E)-l-(2-((7-(3?5-dichloro-4-hydroxyphenyl)-2 / 7-[1.2.3]triazolo[4,5-c|pyri din-2-yl)methyl)-5,7-dihydro-677-pyrrolo[3,4-( ]pyrimidin-6-yl)-4-(piperidin-l-yl)but-2-en-l-one;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1091] or a pharmaceutically acceptable salt of any of the aforementioned.

[1092] In some embodiments, the compound is selected from:

[1093] rac-(E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27f-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-677-pyrrolo[3,4-Z?]pyridin-6-yl)-4-(diethylamino)but-2-en-1-one;

[1094] (7?, E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]l 18yridine-2-yl)ethyl)-5,7-dihydro-677-pyrrolo[3,4-6]118yridine-6-yl)-4-(diethylamino)but-2-en- 1 -one;

[1095] (< S',£ -l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-6 / 7-pyrrolo[3,4-Z?]pyridin-6-yl)-4-(diethylamino)but-2-en- 1-one;

[1096] (E)-l-(2-(2-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27f-[l,2,3]triazolo[4,5-c]pyridin-2-yl)propan-2-yl)-5,7-dihydro-677-pyrrolo[3,4-6]pyridin-6-yl)-4-(dimethy lamino)but-2-en- 1 -one;

[1097] (S,£)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / 7-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67f-pyrrolo[3,4-6]pyridin-6-yl)-4-(2,2-dimethylpyrrolidin-1 -yl)but-2-en- 1 -one;

[1098] rac-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / 7-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-3-lluoro-5,7-dihydro-677-pyrrolo[3,4->]pyridin-6-yl)prop-2-en-l-one;

[1099] (E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-27 / -[l,2.3]triazolo[4,5-c]pyri din-2-yl)cyclobutyl)-5,7-dihydro-677-pyrrolo[3,4-b]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;

[1100] rac-(£’)-l-(2-(cyclopropyl(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5,7-dihydro-67f-pyrrolo[3,4-b]pyridin-6-yl)-4-(dimethy lamino)but-2-en- 1 -one;

[1101] rac-(E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-27f-[l,2,3]triazolo[4,5-c]pyridin- 2-yl)propan-2-yl)-5,7-dihydro-6£7-pyrrolo[3,4-b]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;

[1102] rac-(E)-l-(2-(l-(4-amino-7-(3.5-dichloro-4-hydroxyphenyl)-277-[1.2.3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67 / -pyrrolo[3,4-b]pyridin-6-yl)-4-(2,2-dimethylpyrrolidin-1 -yl)but-2-en- 1 -one;

[1103] (£’)-7-(3,5-dichloro-4-hydroxyphenyl)-2-((6-(4-(diethylamino)but-2-enoyl)-3-methoxy-6,7-dihydro-57f-pyrrolo[3,4-b]pyridin-2-yl)methyl)-277-[l,2,3]triazolo[4,5-c]pyridine-4-carbonitrile;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION

[1104] rac-(E)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(3-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-ethyl-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-2-methoxy-5.7-dihydro-6 / 7-pyrrolo[3,4-Z?]pyridin-6-yl)but-2-en-l-one;

[1105] rac-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methoxy-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-677-pyrrolo[3,4-b]pyridin-6-yl)prop-2-en-l-one;

[1106] rac-(E')-l-(2-(l-(6-chloro-7-(3 5-dichloro-4-hydroxyphenyl)-2 / f-[1.2.3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67 / -pyrrolo[3,4-Z?]pyridin-6-yl)-4-(dimethylamino)but-2-en-l-one;

[1107] (E)-l-(5-(2-(7-(2-chloro-6-methoxypyridin-4-yl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)propan-2-yl)indolin-l-yl)-4-(dimethylamino)but-2-en-l-one;

[1108] (£’)-4-(bis(methyl-d3)amino)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-4-fluoroindolin-l-yl)but-2-en-l-one;

[1109] (£')-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c|pyridin-2-yl)methyl)-3-ethyl-5.7-dihydro-6 / / -pyrrolo|3.4- / ?|pyridin-6-yl)-4-(piperidm-l-yl)but-2-en-l-one;

[1110] (E)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(2-(2-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)propan-2-yl)-4-methoxy-5,7-dihydro-6£7-pyrrolo| 3.4- / ? |pyridin-6-yl)biit-2-cn- 1 -one:

[1111] (E)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -| 1.2.31 tri a / .olo|4.5-c|pyridin-2-vl)methvl)-3-methoxy-5.7-dihydro-67 / -pyrrolo[3,4- / ?]pyrazin-6-yl)but-2-en-l-one;

[1112] / t?c-(E)-l-(2-(l-(7-(3,5-dichloro-44iydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,...

Claims

Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONWhat is claimed is:

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:n is 0, 1, 2, 3, 4, 5, or 6;p is 0, 1, 2, 3, 4, 5, or 6;r is 1 or 2;X is N or CR1;Z is N or CR2;Y is -(Cy^m- Y^s-, wherein Y1is atached to Ring moiety B;m is 1; s is 1; and Y1is a bond: orm is 1; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); or m is 0; s is 1; and Y1is -(CR6R60)r-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O):Cy1is Cs- io cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, or 5-10 membered heteroaryl, which is optionally substituted by 1, 2, 3, 4, 5, or 6 independently selected R10substituents;Ring moiety A is C3-12 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;Ring moiety' B is C3-12 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocycloalkyl, or 5-10 membered heteroaryl;R1is selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORbl, SRbl. NHORal. C(O)Rbl. C(O)NRclRdl, C(O)NRcl(ORal). C(O)ORal. OC(O)Rbl. OC(O)NRclRdl, NRclRdl, NRclNRclRdl, NRclC(O)Rbl, NRclC(O)ORal, NRclC(O)NRclRdl, C(=NRel)Rbl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONC(=NRel)NRclRd1, NRclC(=NRe1)NRc1Rdl, NRc1C(=NRel)Rbl, NRc1S(O)NRc1Rd1, NRclS(O)Rbl, NRclS(O)2Rbl, NRclS(O)(=NRel)Rbl, NRclS(O)2NRclRdl, S(O)Rbl, S(O)NRclRdl, S(O)2Rbl, S(O)2NRclRdl, OS(O)(=NRel)Rbl, OS(O)2Rbl, S(O)(=NRel)Rbl, SFs,P(O)RflRgl, OPCOXOR^XOR11), PCOXOR^XOR*1), and BRJ^1, wherein said Ci-6 alkyd, C2- 6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally^ substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each Ral, Rcl. and Rdlis independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalky 1-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4alky 1 are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each Rb1is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alky l, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each Relis independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4alky 1, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocy cloalkyl-C 1-4 alky 1, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rfland Rglare independently selected from H. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rhland R11is independently selected from H, C1-6 alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;each R'1and Rklis independently selected from OH, C1-6 alkoxy, and C 1-6 haloalkoxy; or any R'1and Rklattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;each R1Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11. SRa11, NH0Ra11. C(O)Rb11, C(O)NRcllRd11, C(O)NRcll(ORa11), C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllNRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, C(=NRell)Rb11, C(=NRell)NRcllRd11, NRcllC(=NRell)NRcllRd11, NRcllC(=NRell)Rb11, NRcllS(O)NRcllRd11, NRcllS(O)Rb11, NRcllS(O)2Rb11, NRcllS(O)(=NRell)Rb11, NRcllS(O)2NRcllRd11, S(O)Rb11. S(O)NRcllRd11, S(O)2Rb11. S(O)2NRcllRd11.OS(O)(=NRell)Rb11, OS(O)2Rbn, S(O)(=NRell)Rb11, SF5, P(O)RfllRg11, OP(O)(ORh11)(ORi11), P(O)(ORh11)(ORi11), and BR'11Rk11, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor, any Rc11and Rd11atached to the same N atom, together with the N atom to which they are atached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;each Rbl1is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Bsubstituents;each Rel1is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rfl1and Rgl1are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rhl1and R111is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;each R'11and Rkl1is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any R'" and Rkl1attached to the same B atom, together with the B atom to which they are atached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl; each R1Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa12, SRa12, NHORa12, C(O)Rb12, C(O)NRc12Rd12, C(O)NRcl2(ORa12), C(O)ORa12, OC(O)Rb12, OC(O)NRc12Rd12,NRel2Rdl2NRcl2NRel2Rdl2NRcl2C(O)Rbl2 NRc12C(O)ORa12, NRcl2C(O)NR°12Rd12, C(=NRcl2)Rb12, C(=NRcl2)NRc12Rd12, NRcl2C(=NRcl2)NRc12Rd12. NRcl2C(=NRcl2)Rb12,NRcl2S(O)NRc12Rd12, NRcl2S(O)Rb12, NRcl2S(O)2Rb12, NRcl2S(O)(=NRel2)Rb12,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONNRcl2S(O)2NRc12Rd12, S(O)Rbl2, S(O)NRc12Rd12, S(O)2Rb12, S(O)2NRc12Rd12, OS(O)(=NRel2)Rb12, OS(O)2Rb12, S(O)(=NRel2)Rb12, SFs, P(O)Rfl2Rg12, OP(O)(ORhl2)(ORi12), P(O)(ORhl2)(ORi12), and BRjl2Rk12, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra12, Rc12, and Rd12is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyd, 5-6 membered heteroaryl, C3-7Cycloalkyl-Ci-4alky 1, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl. C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryd, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyd, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-6 membered heteroary l-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;or, any Rcl2and Rdl2attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyd group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rbl2is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cy cloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyd, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalky l-C 1-4 alkyd, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rel2is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalky 4, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky l-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each R112and Rgl2are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalky 4, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryd, C3-7 cycloalkyd-C 1-4 alkyd, phenyl-C 1-4 alky l, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-6 membered heteroary l-C 1-4 alkyl;each R1112and R112is independently selected from H. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONheteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;each R-'12and Rkl2is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any R'12and Rkl2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;R2is selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORb2. SRh2. NHORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)NRc2(ORa2), C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(=NRe2)Rb2, C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)(=NRe2)Rb2. NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, S(O)2NRc2Rd2, OS(O)(=NRe2)Rb2, OS(O)2Rb2, S(O)(=NRe2)Rb2, SF5,P(O)Rf2Rg2, OP(O)(ORb2)(OR12), P(O)(ORb2)(ORi2), and BR>2Rk2, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalky l, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;each Ra2, Rc2, and Rd2is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryL C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alky l, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalky 1-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;each Rb2is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl. which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;each Re2is independently selected from H, OH, CN, C1-6 alkyd, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyd, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rf2and Rg2are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkyny l, C3-10 cycloalky 1, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;each Rh2and R12is independently selected from H, C1-6 alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl;each R'2and Rk2is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Ri?and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;each R2Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa21, SR;'21, NHORa21, C(O)Rb21, C(O)NRc21Rd21, C(O)NRc21(ORa21), C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, C(=NRe21)Rb21, C(=NRe21)NRc21Rd21, NRc21C(=NRe21)NRc21Rd21, NRc21C(=NRe21)Rb21, NRc21S(O)NRc21Rd21, NRc21S(O)Rb21, NRc21S(O)2Rb21, NRc21S(O)(=NRc21)Rb21, NRc21S(O)2NRc21Rd21, S(O)Rb21, S(O)NRc21Rd21, S(O)2Rb21, S(O)2NRc21Rd21,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONOS(O)(=NRe21)Rb21, OS(O)2Rb21, S(O)(=NRe21)Rb21, SF5, P(O)Rf21Rg21, OP(O)(ORh21)(OR‘21), P(O)(ORh21)(OR‘21), and BR21Rk21, wherein said Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R2Bsubstituents;each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyd, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted w ith 1, 2, 3, or 4 independently selected R2Bsubstituents;or, any Rc21and Rd21attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally' substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;each Rb21is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents;each Re21is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each R121and Rs21are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rb21and R121is independently selected from H. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONheteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;each R-'21and Rk21is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any R'21and Rk21attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl; each R2Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa22. SRa22, NHORa22. C(O)Rb22, C(O)NRc22Rd22, C(O)NRc22(ORa22), C(O)ORa22, OC(O)Rb22, OC(O)NRc22Rd22,NRe22Rd22NRc22NRc22Rd22 NRc22C(O)Rb22, NRc22C(O)ORa22, NRc22C(O)NRc22Rd22, C(=NRe22)Rb22, C(=NRe22)NRc22Rd22, NRc22C(=NRe22)NRc22Rd22, NRc22C(=NRe22)Rb22, NRc22S(O)NRc22Rd22, NRc22S(O)Rh22, NRc22S(O)2Rb22, NRc22S(O)(=NRe22)Rb22, NRc22S(O)2NRc22Rd22, S(O)Rb22, S(O)NRc22Rd22, S(O)2Rb22, S(O)2NRc22Rd22,OS(O)(=NRe22)Rb22, OS(O)2Rb22, S(O)(=NRe22)Rb22, SFs, P(O)Rf22R822, OP(O)(ORh22)(ORi22), P(O)(ORh22)(ORi22), and BRj22Rk22, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra22, Rc22, and Rd22is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;or, any Rc22and Rd22attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalk l group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach Rb22is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re22is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf22and Rg22are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh22and R122is independently selected from H, C1-6 alky l, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each R'22and Rk22is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any R-'22and Rk22attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa3, SRa3, NHORa3, C(O)Rb3, C(O)NRc3Rd3, C(O)NRc3(ORa3), C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, C(=NRe3)Rb3. C(=NRe3)NRc3Rd3. NRc3C(=NRe3)NRc3Rd3, NRc3C(=NRe3)Rb3. NRc3S(O)NRc3Rd3. NRc3S(O)Rb3, NRe3S(O)2Rb3, NRe3S(O)(=NRe3)Rb3. NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach Ra3, Rc3, and Rd3is independently selected from H, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb3is independently selected from C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaiyl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyd, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re3is independently selected from H, OH, CN, C1-6 alky l, C1-6 alkoxy, C1-6 haloalkyl, and C 1-6 haloalkoxy;R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-4 cycloalkyl, ORa4, SRa4, NHORa4, C(O)Rb4, C(O)NRc4Rd4, C(O)NRc4(ORa4), C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4. NRc4S(O)NRc4Rd4. NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)(=NRe4)Rh4.NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra4, Rc4. and Rd4is independently selected from H. C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryd, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroary l-C 1-4 alkyl, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryd, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb4is independently selected from C1-6 alky l, C2-6 alkeny l, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyd, 4-7 membered heterocycloalky I-C1-4 alkyl, and 5-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re4is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C 1-6 haloalkoxy;each R5is independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa5, SRa5, NHORa5, C(O)Rb5, C(O)NRc5Rd5, C(O)NRc5(ORa5), C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRo5C(O)NRc5Rd5, C(=NRc5)Rb5, C(=NRc5)NRc5Rd5, NRc5C(=NRc5)NRc5Rd5. NRc5C(=NRc5)Rb5. NRc5S(O)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)(=NRe5)Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, S(O)2NRc5Rd5, OS(O)(=NRe5)Rb5, OS(O)2Rb5,S(O)(=NRe5)Rb5, SF5, P(O)Rf5Rg5, OP(O)(ORh5)(ORi5), P(O)(ORh5)(ORi5), and BRj5Rk5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl. C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl -C 1-4 alkyd, and 5-10 membered heteroar l-C 1-4 alky l are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;each Ra5. Rc5. and Rd’ is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alky l, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-C 1-4 alkyl, and 5-10 membered heteroary l-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;or, any Re5and Rd5attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;each Rb5is independently selected from C1-6 alkyl, C1-6 haloalkyl. C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alk l. which are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;each Re3is independently selected from H, OH, CN, C1-6 alkyl, C 1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3- 10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl;each Rf5and Rg5are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky l, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary 1. C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyl;each Rh5and Ri5is independently selected from H, C1-6 alkyl, C 1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroary 1-C 1-4 alkyd;each and Rk5is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any R'5and Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl;each R5Ais independently selected from D, halo, CN, NO2, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky 4, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyd. phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa51, SR151, NHORa51, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51, NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, C(=NRe51)Rb51, C(=NRe51)NRc51Rd51, NRc51C(=NRe51)NRc51Rd51, NRc51C(=NRe51)Rb51, NRc51S(O)NRe51Rd51, NRc51S(O)Rb51, NRc51S(O)2Rb51, NRe51S(O)(=NRe51)Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51, S(O)2NRc51Rd51,OS(O)(=NRe51)Rb51, OS(O)2Rb51, S(O)(=NRe51)Rb51, SFs, P(O)Rf51Rg51, OP(O)(ORh51)(OR151), P(O)(ORh51)(OR‘51), and BRj51Rk51, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky I-C1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONheterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected RGsubstituents;each Ra51, Rc51, and Rd51is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;or, any Rc51and Rd51attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb51is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re51is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf51and Rg51are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh51and R151is independently selected fromH. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rj51and Rk51is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor any Rj51and Rk51attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl;each R6is independently selected from H, D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-Ci-4 alkyl, ORa6, SRa6, NHORa6, C(O)Rb6, C(O)NRc6Rd6, C(O)NRc6(ORa6), C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(O)NRc6Rd6. NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)(=NRe6)Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, S(O)2NRc6Rd6, OS(O)(=NRe6)Rb6, OS(O)2Rb6,S(O)(=NRe6)Rb6, SF5, P(O)Rf6Rg6, OP(O)(ORh6)(ORi6), P(O)(ORh6)(ORi6), and BR|6Rk6. wherein said C1-6 alkyl, C2-6 alkeny l. C2-6 alkyny l, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl -C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4alky 1 are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;each Ra6, Rc6. and Rd6is independently selected from H. C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1. 6-10 membered aryl. 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalkyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;or, any Rc6and Rd6attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;each Rb6is independently selected from C1-6 alkyl, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl. 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1. 2, 3, or 4 independently selected R6Asubstituents;each Re6is independently selected from H, OH, CN, Ci-6 alkyl, Ci-6 alkoxy, Ci-6 haloalkyl, Ci-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rf6and Rg6are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rh6and Ri6is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered ary l, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl;each Rj6and Rk6is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any R'6and Rk6attached to the same B atom, together wi th the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1. 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl;each R6Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa61. SRa61, NHORa61, C(O)Rb61, C(O)NRc61Rd61, C(O)NRc61(ORa61), C(O)ORa61, OC(O)Rb61, OC(O)NRc61Rd61, NRc61Rd61, NRc61NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, C(=NRe61)Rb61, C(=NRe61)NRc61Rd61, NRc61C(=NRe61)NRc61Rd61, NRc61C(=NRe61)Rb61, NRc61S(O)NRc61Rd61, NRc61S(O)Rb61, NRc61S(O)2Rb61, NRc61S(O)(=NRe61)Rb61, NRc61S(O)2NRc61Rd61, S(O)Rb61, S(O)NRc61Rd61, S(O)2Rb61. S(O)2NRc61Rd61.OS(O)(=NRe61)Rb61, OS(O)2Rb61, S(O)(=NRe61)Rb61, SF5, P(O)Rf61Rg61, OP(O)(ORh61)(ORi61), P(O)(ORh61)(ORi61), and BR'61Rk61, wherein said C1-6 alky l, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 memberedAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONheterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C i-4 alkyl are each optionally substituted with 1, 2. 3, or 4 independently selected R6Bsubstituents;each Ra61, Rc61, and Rd61is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;or, any Rc61and Rd61attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;each Rb61is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Bsubstituents;each Re61is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf61and Rg61are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh61and Ri61is independently selected fromH. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rj61and Rk61is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor any R'61and Rk61atached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R6Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa62, SRa62, NHORa62, C(O)Rh62, C(O)NRc62Rd62, C(O)NRc62(ORa62), C(O)ORa62, OC(O)Rb62, OC(O)NRc62Rd62, NRc62Rd62, NRc62NRc62Rd62, NRc62C(O)Rb62, NRc62C(O)ORa62, NRc62C(O)NRc62Rd62, C(=NRe62)Rb62, C(=NRe62)NRc62Rd62, NRc62C(=NRe62)NRc62Rd62, NRc62C(=NRe62)Rb62, NRc62S(O)NRc62Rd62, NRc62S(O)Rb62, NRc62S(O)2Rb62, NRc62S(O)(=NRc62)Rb62, NRc62S(O)2NRc62Rd62, S(O)Rb62, S(O)NRc62Rd62, S(O)2Rb62, S(O)2NRc62Rd62, OS(O)(=NRe62)Rb62, OS(O)2Rb62, S(O)(=NRe62)Rb62, SF5, P(O)Rf62Rg62, OP(O)(ORh62)(ORi62), P(O)(ORh62)(ORi62), and BRj62Rk62, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra62, Rc62, and Rd62is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-C1-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;or, any Rc62and Rd62attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb62is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re62is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf62and Rg62are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh62and Ri62is independently selected from H. C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l;each Rj62and Rk62is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any Rj62and Rk62attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; each R60is independently selected from H. D, C1-6 alkyl, and C1-6 haloalkyl;or R6and R60, together with the carbon atom to which they are attached, form a C3-10 cycloalkyl or a 4-10 membered heterocycloalkyl moiety7, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each R7is independently selected from D, halo, CN. NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C 1-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, 5-10 membered heteroaryl-C 1-4 alkyl, ORa7, SRa7, NHORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)NRc7(ORa7), C(O)ORa7, OC(O)Rb7, OC(O)NRe7Rd7, NRe7Rd7, NRe7NRc7Rd7. NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRe7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(O)NRc7Rd7, NRc7S(O)Rb7, NRc7S(O)2Rb7, NRc7S(O)(=NRe7)Rb7, NRc7S(O)2NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, S(O)2NRc7Rd7, OS(O)(=NRe7)Rb7, OS(O)2Rb7,S(O)(=NRc7)Rb7. SF5, P(O)Rf7Rg7. OP(O)(ORh7)(ORi7). P(O)(ORh7)(ORi7). and BRj7Rk7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C 1-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-C'1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;or, any Rc7and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Rb7is independently selected from C1-6 alky l, C1-6 haloalky l, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl. 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alkyl. 4-10 membered heterocycloalkyl-C1-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Re7is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3- 10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C1-4 alkyl, 4-10 membered heterocy cloalkyl-C 1-4 alkyl, and 5-10 membered heteroary I-C1-4 alkyl;each Rf7and Rg7are independently selected from H. C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroary l, C3-10 cycloalkyl-Ci-4 alkyl, 6-10 membered aryl-Ci-4 alky l, 4-10 membered heterocy cloalkyl-C 1-4 alky 1, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rh7and Ri7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalky 1, 6-10 membered aryl, 4-10 membered heterocycloalkyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION5-10 membered heteroaryl, C3-iocycloalkyl-Ci-4 alkyl, 6-10 membered aryl-C t-4 alkyl, 4-10 membered heterocycloalkyl-Ci-4 alkyl, and 5-10 membered heteroaryl-Ci-4 alkyl;each Rj7and Rk7is independently selected from OH, Ci-6 alkoxy, and Ci-6 haloalkoxy; or any Rj7and Rk7attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl; each R7Ais independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyd, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa71, SRa71, NHORa71, C(O)Rb71, C(O)NRc71Rd71. C(O)NRc71(ORa71). C(O)ORa71, OC(O)Rb71, OC(O)NRc71Rd71, NRc71Rd71, NRc71NRc71Rd71, NRc71C(O)Rb71, NRc71C(O)ORa71, NRc71C(O)NRc71Rd71, C(=NRe71)Rb71, C(=NRe71)NRc71Rd71, NRc71C(=NRe71)NRc71Rd71, NRc71C(=NRe71)Rb71, NRc71S(O)NRc71Rd71, NRc71S(O)Rb71, NRc71S(O)2Rb71, NRc71S(O)(=NRe71)Rb71, NRc71S(O)2NRc71Rd71, S(O)Rb71. S(O)NRc71Rd71, S(O)2Rb71. S(O)2NRc71Rd71, OS(O)(=NRe71)Rb71, OS(O)2Rb71, S(O)(=NRe71)Rb71, SF5, P(O)Rf71Rg71, OP(O)(ORh71)(ORi71), P(O)(ORh71)(ORi71), and BR'71Rk71, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alky l. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach Rb71is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;each Re71is independently selected from H, OH. CN, C1-6 alkyl. C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf71and Rg71are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh71and Ri71is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rj71and Rk71is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy;or any Rj71and Rk71attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C 1-6 haloalkyl; each R7Bis independently selected from D, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl. 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, ORa72, SRa72, NHORa72, C(O)Rb72, C(O)NRc72Rd72, C(O)NRc72(ORa72), C(O)ORa72, OC(O)Rb72, OC(O)NRc72Rd72, NRc72Rd72, NRc72NRc72Rd72, NRc72C(O)Rb72. NRc72C(O)ORa72, NRc72C(O)NRc72Rd72. C(=NRe72)Rb72, C(=NRe72)NRc72Rd72, NRc72C(=NRe72)NRc72Rd72, NRc72C(=NRe72)Rb72, NRc72S(O)NRc72Rd72, NRc72S(O)Rb72, NRc72S(O)2Rb72, NRc72S(O)(=NRe72)Rb72, NRc72S(O)2NRc72Rd72, S(O)Rb72, S(O)NRc72Rd72, S(O)2Rb72, S(O)2NRc72Rd72,OS(O)(=NRe72)Rb72, OS(O)2Rb72, S(O)(=NRe72)Rb72, SF5, P(O)Rf72Rg72, OP(O)(ORh72)(ORi72), P(O)(ORh72)(ORi72), and BRj72Rk72, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION5-6 membered heteroaryl, C3-7 cycloalky l-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra72, Rc72, and Rd72is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;or, any Rc72and Rd72attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb72is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re72is independently selected from H, OH, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rf72and Rg72are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C 1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh72and Ri72is independently selected from H. C1-6 alkyl. C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl;each Rj72and Rk72is independently selected from OH. C1-6 alkoxy, and C1-6 haloalkoxy;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor any Rj72and Rk72attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6 alkyl and Ci-6 haloalkyl;Rwis a covalent warhead moiety7having a reactive functional group capable of covalently binding to one or more cysteine residues in a protein;each R10is independently selected from D. halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORal°, SRal°, NHORal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)NRcl0(ORal°), C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°, NRcl0C(O)NRcl0Rdl°. NRcl0S(O)NRcl0Rdl°, NRcl0S(O)Rbl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRcl0Rdl°, S(O)Rbl°, S(O)NRcl0Rdl°, S(O)2Rbl°, and S(O)2NRcl0Rdl°, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C3-7 cycloalky l, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Ra10, Rc10, and Rd10is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-Ci-4 alkyl, 4-7 membered heterocy cl oalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocy cloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;or, any Rc10and Rd10attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocy cloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2. 3, or 4 independently selected R3Asubstituents;each Rb10is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl. C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R3Asubstituents; andAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach RGis independently selected from D, OH, NO2, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl. cyano-Ci-3 alkyl. HO-C1-3 alkyl. C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, N(CDs)2, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di (C 1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(Ci-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-3 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Rwis a means for covalently binding to cysteine residue in a protein.

3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Rwis:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONL1is -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-, -L-S(O)-. -L-S(O)2-, -L-NR9S(O)-. -L-OS(O)-, -L-NR9S(O)2-, or -L-OS(O)2-, wherein L1is atached to Ring moiety B through the L linking group;L2is -L-, -L-O-, -L-NR9-, -L-S-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-:-L-S(O)-, -L-S(O)2-, -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)NR9-, -L-NR9S(O)O-, -L-OS(O)NR9-. -L-NR9S(O)2-, -L-OS(O)2-. -L-NR9S(O)2NR9-. -L-NR9S(O)2O-, -L-S(O)(NR9)-. -L-S(O)2(NR9)-, or -L-OS(O)2NR9-, wherein L2is atached to Ring moiety B through the L linking group;L3is -L-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-, -L-S(O)-, -L-S(O)2-, -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)2-, or -L-OS(O)2-, wherein L3is attached to Ring moiety B through the L linking group;L4is -L-, -L-O-, L-S-, or -L-NR9-, wherein L4is atached to Ring moiety B through the L linking group;L6is -L-, -L-O-, -L-NR9-, -L-S-, -L-C(O)-, -L-NR9C(O)-, -L-OC(O)-, -L-S(O)-, -L-S(O)2-, -L-NR9S(O)-, -L-OS(O)-, -L-NR9S(O)NR9-, -L-NR9S(O)O-, -L-OS(O)NR9-. -L-NR9S(O)2-, -L-OS(O)2-, -L-NR9S(O)2NR9-, -L-NR9S(O)2O-, -L-S(O)(NR9)-, -L-S(O)2(NR9)-, or -L-OS(O)2NR9-, wherein L6is atached to Ring moiety D through the L linking group;L is a bond or Ci-6 alkylene, wherein said Ci-6 alky lene is optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents; orL is -O-Ci-6 alkyl or -N(RN)-CI-6 alkyl, wherein L is atached to Ring moiety A via the oxygen of the -O-Ci-6 alkyl or the nitrogen atom of the -N(RN)-CI-6 alkyl group;each RNis independently H or Ci-6 alkyl;Ring D is a 4-12 membered heterocycloalkyl, C3-12 cycloalkyl, Ce-io aryl, or a 5-10 membered heteroaryl, each of which is optionally substituted with 1, 2. 3, or 4 independently selected C1-6 alkyl groups;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONGis 0 or NR9;each t is independently 0, 1, 2, or 3;each R81and R83are independently selected from H, D, halo, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl. ORa8, SRa8, NHOR18, C(O)Rh8, C(O)NRc8Rd8, C(O)NRc8(ORa8). C(O)ORa8. OC(O)Rb8. OC(O)NRc8Rd8, NRc8Rd8, NRc8NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8, NRc8C(O)NRc8Rd8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, NRc8C(=NRe8)NRc8Rd8, NRc8C(=NRe8)Rb8, NRc8S(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8, NRo8S(O)(=NRe8)Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, S(O)2NRc8Rd8, OS(O)(=NRc8)Rb8, OS(O)2Rb8. S(O)(=NRc8)Rb8. SF5, P(O)RISR"8. OP(O)(ORh8)(OR18), P(O)(ORh8)(ORi8), and BRj8Rk8; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C 1-6 haloalkyl, C3-7 cycloalkyd, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalky 1-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;each R82is independently selected from H, D, halo, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkyny l, C1-6 haloalky l, C3-7 cycloalky 1, pheny l, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, C(O)Rb8, C(O)NRc8Rd8. C(O)ORa8, C(=NRe8)Rb8, C(=NRe8)NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, and S(O)2NRc8Rd8; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alky nyl, C1-6 haloalky l, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;each Ra8, Rc8, and Rd8is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl. C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach Rb8is independently selected from Ci-6 alky l, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Re8is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rreand Rg8are independently selected from H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl. 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rh8and R18is independently selected from H, C1-6 alkyl, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl;each Rj8and Rk8is independently selected from OH, C1-6 alkoxy, and C1-6 haloalkoxy; or any Rj8and Rk8attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6 alkyl and C1-6 haloalkyl; or any two R81and R82together with the atoms to which they are attached, form C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, or 5-6-membered heteroaryl ring, each of which is optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;each R9is independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C 3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocy cloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, ORa9, SRa9, NHORa9, C(O)Rb9, C(O)NRc9Rd9, C(O)NRc9(ORa9), C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)ORa9, NRc9C(O)NRc9Rd9, C(=NRe9)Rb9, C(=NRe9)NRc9Rd9, NRc9C(=NRe9)NRc9Rd9, NRc9C(=NRe9)Rb9, NRc9S(O)NRc9Rd9, NRc9S(O)Rb9, NRc9S(O)2Rb9, NRc9S(O)(=NRe9)Rb9, NRc9S(O)2NRc9Rd9. S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, S(O)2NRc9Rd9,OS(O)(=NRc9)Rb9. OS(O)2Rb9, and S(O)(=NRc9)Rb9, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted by 1, 2, 3, or 4 independently selected RGsubstituents;each Ra9, Rc9, and Rd9is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3. or 4 independently selected RGsubstituents;or, any Rc9and Rd9attached to the same N atom, together wi th the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, which is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb9is independently selected from C1-6 alkyl, C1-6 haloalkyl. C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents; andeach Re9is independently selected from H, OH, CN. C1-6 alkyl, C1-6 alkoxy. C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky l, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl.

4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Rwis selected from:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Rwis selected from:I- L2R82?\yR82R82and R81.

6. The compound of any one of claims 3-5. or a pharmaceutically acceptable salt thereof, wherein L1is -L-C(O)-, -L-NR9C(O)-, -L-S(O)2-, -L-NR9S(O)-, or -L-NR9S(O)2-, or wherein L1is attached to Ring moiety B through the L linking group; L is a bond; and R9is selected from H and Ci-6 alkyl.

7. The compound of any one of claims 3-5. or a pharmaceutically acceptable salt thereof, wherein L2is -C(O)-, -NR9C(O)-, -S(O)2-, or -NR9S(O)2< and R9is selected from H and Ci-3 alkyl.

8. The compound of claim any one of claims 3-7, or a pharmaceutically acceptable salt thereof, wherein R81, R82, and R83are each independently selected from H, halo, CN, Ci-6 alkyl, Ci-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-CT-4 alkyl. 5-6 membered heteroaryl-Ci-4 alkyl, ORa8, C(O)Rb8, C(O)NRc8Rd8, and C(O)ORa8, wherein said Ci-6 alkyl, Ci-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroary l-Ci-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino, C1-3 alkydamino, and di(Ci-3 alkyl)amino.

9. The compound of any one of claims 1-8, or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, 3, or 4.

10. The compound of any one of claims 1-9. or a pharmaceutically acceptable salt thereof, wherein p is 0, 1, or 2.

11. The compound of any one of claims 1-10, or a pharmaceutically acceptable salt thereof, wherein R1is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl,Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONphenyl. 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2. 3, or 4 independently selected R1Asubstituents.

12. The compound of any one of claims 1-11, or a pharmaceutically acceptable salt thereof, wherein:each Ral, Rcl. and Rdlis independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyd, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each Rblis independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rbn, and S(O)2NRcllRdn;each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; andeach Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl.

13. The compound of any one of claims 1-12, or a pharmaceutically acceptable salt thereof, wherein R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION14. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein m is 1; s is 1; and Y1is -CR6R60- or C(O).

15. The compound of any one of claims 1-14, or a pharmaceutically acceptable salt thereof, wherein Cy1is 4-10 membered heterocycloalkyl, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents.

16. The compound of any one of claims 1-15, or a pharmaceutically acceptable salt thereof, wherein Cy1is an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or an azepine ring, which are each optionally substituted by 1, 2, 3, or 4 independently selected R10substituents.

17. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein m is 0; s is 1; and Y1is -CR6R60- or C(O).

18. The compound of any one of claims 1-16, or a pharmaceutically acceptable salt thereof, wherein each R10is independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°, SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°, OC(O)NRcl0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°. NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rd10;each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; andeach Rb1° is independently selected from C1-6 alkyl and C1-6 haloalkyl.

19. The compound of any one of claims 1-18, or a pharmaceutically acceptable salt thereof, wherein each R6is independently selected from H, D, halo, CN, C1-6 alkyl, C1-6 haloalkyl, and C3-7 cycloalkyl.

20. The compound of any one of claims 1-19, or a pharmaceutically acceptable salt thereof, wherein each R60is independently selected from H, D and C1-3 alkyl.

21. The compound of any one of claims 1-18, or a pharmaceutically acceptable salt thereof, wherein R6and R60, together with the carbon atom to which they are attached, form aAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONC3-10 cycloalkyl moiety, which is optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

22. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt thereof, wherein Ring moiety' B is phenyl, naphthyl, 5-10 membered heteroaryl, or 9-12 membered heterocycloalkyl.

23. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt thereof, wherein Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl, 9-10| — fAr1J °y2N— |membered heteroaryl, orN — ■ wherein:Ar1is fused to Cy2and Ar1is bonded to Y;Ar1is phenyl or 5-6 membered heteroaryl; andCy2is 4-8 membered heterocycloalkyl.

24. The compound of any one of claims 1-23, or a pharmaceutically acceptable salt thereof, wherein R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl. C1-6 haloalkyl, ORaa, and NRc3Rd3.

25. The compound of any one of claims 1-24, or a pharmaceutically acceptable salt thereof, wherein each Ra3, Rc3, and Rd3is independently selected from H and C1-6 alkyl.

26. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl.

27. The compound of any one of claims 1-26, or a pharmaceutically acceptable salt thereof, wherein Ring moiety A is 6-10 membered and or 5-10 membered heteroaryl.

28. The compound of any one of claims 1-27, or a pharmaceutically acceptable salt thereof, wherein each R5is independently selected from halo. CN, C1-3 alkyl. C1-3 haloalkyl, OH, C1-3 alkoxy, and C1-3 haloalkoxy.

29. The compound of any one of claims 1-28, or a pharmaceutically acceptable salt thereof, wherein:Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION, wherein X1and X2are each independently Cl or F, and X3is H, Cl or F.

30. The compound of any one of claims 1-28, or a pharmaceutically acceptable salt thereof, wherein:(R13)kiX1is Cl, F, or OCH3;X2is H, Cl, or F;X3is H, Cl or F;R11is OH or CN;kl is 0, 1, or 2;k2 is 2;two R12substituents, together with the carbon atoms to which they are attached, form a pyrazole, pyrrole, or pyrimidine ring, which is optionally substituted by 1 or 2 substituents independently selected from halo, CN, and C1-3 alkyl; andeach R13is independently selected from halo, CN, C1-3 alkyl, and methoxy.

31. The compound of any one of claims 1-30, or a pharmaceutically acceptable salt thereof, wherein each R7is independently selected from halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, andNRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alky lidene-C'3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl. C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONmembered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents.

32. The compound of any one of claims 1-31, or a pharmaceutically acceptable salt thereof, wherein:each Ra7, Rc7, and Rd7is independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl, wherein said Ci-6 alkyl and Ci-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Rb7is independently selected from Ci-6 alkyl and Ci-6 haloalkyl, which are each optionally substituted with 1, 2, 3. or 4 independently selected R7Asubstituents;each R7Ais independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, andNRc71Rd71;each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1. 2, 3, or 4 independently selected R7Bsubstituents;or, any Rc71and Rd71attached to the same N atom, together with the N atom to which they are attached, form a 4-7 membered hcterocycloalk I group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; andeach Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl. C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(C 1-3 alkyl)amino.

33. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1, 2, 3. or 4;p is 0, 1, 2, 3, or 4;m is 1; s is 1; and Y1is a bond; orm is 1; s is 1; and Y1is -CR6R60-, -(CR6R60)2-, -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O); orm is 0; s is 1; and Y1is -CR6R60-, -(CR6R60)2- -CR6R60-C(O)-. -C(O)-CR6R60-, or C(O);Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONCy1is 4-7 membered heterocycloalkyl having 1 or 2 nitrogen ring members, which is optionally substituted by 1, 2, 3, or 4 independently selected R10substituents;Ring moiety A is phenyl, 5-6 membered heteroaryl, or 9-10 membered heteroaryl; Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl. 9-10 memberedheteroaryl, orAr1is fused to Cy2and Ar1is bonded to Y;Ar1is phenyl or 5-6 membered heteroaryl;Cy2is 4-8 membered heterocycloalkyl;X is N or CR1;Z is N or CR2;R1is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each R1Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocy cloalkyl, 5-6 membered heteroaryl, C3-7cycloalkyl-Ci-4 alkyl. phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa11, SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11, OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;each Ral1, Rcl1, and Rdl1is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;each Rbl1is independently selected from C1-6 alkyl and C1-6 haloalkyl;R2is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-5 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl. C1-6 haloalkyl, and C3-5 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach R2Ais independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa21, SRa21, C(O)Rb21, C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21. OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21;each Ra21, Rc21, and Rd21is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;each Rb21is independently selected from C1-6 alkyl and C1-6 haloalkyl;R3is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa3, and NRc3Rd3;each Ra3, Rc3. and Rd3is independently selected from H and C1-6 alkyl;R4is selected from H, D. halo. CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;R3is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-4 cycloalkyl, ORa5and NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, and C3-4 cycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;each Ra3, Rc5, and Rd3is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-4 cy cloalkyl, and 4-5 membered heterocycloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents;each R5Ais independently selected from OH, CN. halo, C1-3 alkyl, C1-3 haloalkyl. amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;each R6is independently selected from H, D, halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6. NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)2NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;each R60is independently selected from H. C1-6 alkyl, and C1-6 haloalkyl;or R6and R60, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl or a 4-7 membered heterocycloalkyl moiety, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Ra6, Rc6. and Rd6is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONhaloalky 1 are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;each Rb6is independently selected from Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R6Asubstituents;each R6Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl. C2-6 alkynyl, C1-6 haloalkyl, ORa61. SRa61, C(O)Rb61. C(O)NRc61Rd61, C(O)ORa61, OC(O)Rb61. OC(O)NRc61Rd61, NRc61Rd61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, NRc61S(O)2NRc61Rd61, S(O)2Rb61, and S(O)2NRc61Rd61;each Ra61, Rc61, and Rd61is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;each Rb61is independently selected from C1-6 alkyl and C1-6 haloalkyl;each R7is independently selected from halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalky l, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, ORa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, and NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alky lidene-Cs-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalky 1, phenyl, 4-7 membered heterocycloalky l, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Ra7, Rc7, and Rd7is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, pheny l, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-Ci-4 alkyl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-C 1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroary l, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alky 1, 4-7 membered heterocycloalky 1-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alky l are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Rb7is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-7 cycloalkyl-C 1-4 alkyl, phenyl-C 1-4 alkyl, 4-7 membered heterocycloalkyl-C 1-4 alkyl, and 5-6 membered heteroaryl-C 1-4 alkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach R7Ais independently selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaiyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;each Rb71is independently selected from C1-6 alkyl and C1-6 haloalkyl;Rwis selected from:L2is -C(O)-, -NR9C(O)-, -S(O)2-, or -NR9S(O)2-;provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1:R9is selected from H and C1-3 alkyl;R81and R82are each independently selected from H, halo, CN, C1-6 alky l, C1-6 haloalkyl, 5-6 membered heteroaryl. 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, ORa8, C(O)Rb8, C(O)NRc8Rd8, and C(O)ORa8, wherein said C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaryl-Ci-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino. C1-3 alkylamino, and di(Ci-3 alkyl)amino;each Ra8, Rc8, and Rd8is independently selected from H and C1-6 alkyl;each R10is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORal°, SRal°, C(O)Rbl°, C(O)NRcl0Rdl°, C(O)ORal°, OC(O)Rbl°, OC(O)NRol0Rdl°, NRcl0Rdl°, NRcl0C(O)Rbl°, NRcl0C(O)ORal°. NRcl0C(O)NRcl0Rdl°, NRcl0S(O)2Rbl°, NRcl0S(O)2NRc10Rd10, S(O)2Rbl°, and S(O)2NRcl0Rd10;each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;each Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl; and each RGis independently selected from D, OH, NO2, CN, halo. C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-Ci-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-Ci-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C 1-3 haloalkoxy, amino, C1-3 alkylamino, di(Ci-3 alkyl)amino, N(CD3)2, thio, C1-3 alkylthio. C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONalkylcarbamyl, di (C 1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-3 alkoxy carbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkoxycarbonylamino, C1-3 alkylaminocarbonyloxy, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(C 1-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(Ci-s alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(Ci-3 alkyl)aminocarbonylamino.

34. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1, 2, 3, or 4;p is 0, 1, 2, 3, or 4;m is 1; s is 1: andY1is a bond: orm is 1; s is 1; and Y1is -CR6R60-, -(CR6R60)2-, or C(O); orm is 0; s is 1; andY1is -CR6R60-, -(CR6R60)2-, or C(O); Cy1is an azetidine ring, a pyrrolidine ring, or a piperidine ring, which are each optionally substituted by 1 or 2 independently selected R10substituents;Ring moiety A is phenyl, 5-6 membered heteroaryl, or 9-10 membered heteroaryl; Ring moiety B is phenyl, naphthyl, 5-6 membered heteroaryl. 9-10 memberedheteroaryl, orAr1is fused to Cy2and Ar1is bonded to Y;Ar1is phenyl or 5-6 membered heteroaryl;Cy2is 4-8 membered heterocycloalkyl;X is N or CR1;Z is N or CR2;R1is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CsucycloalkyL phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R1Asubstituents;each R1Ais independently selected from D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa11. SRa11, C(O)Rb11, C(O)NRcllRd11, C(O)ORa11, OC(O)Rb11. OC(O)NRcllRd11, NRcllRd11, NRcllC(O)Rb11, NRcllC(O)ORa11, NRcllC(O)NRcllRd11, NRcllS(O)2Rb11, NRcllS(O)2NRcllRd11, S(O)2Rb11, and S(O)2NRcllRd11;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONeach Ra11, Rcl 1, and Rdnis independently selected from H, Ci-6 alkyl, and Ci-6 haloalkyl;each Rbl1is independently selected from Ci-6 alkyl and Ci-6 haloalkyl;R2is selected from H, D, halo, CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;R3is selected from H, D. halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;R4is selected from H, D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl;each R5is independently selected from halo, CN, C1-3 alky l, C1-3 haloalkyl, OH, C1-3 alkoxy, and C1-3 haloalkoxy;each R6is independently selected from H, D, halo, CN, C1-6 alkyl, and C1-6 haloalkyl; each R60is independently selected from H and C1-3 alkyl;or R6and R60, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl moiety optionally substituted with 1 or 2 independently selected R7Asubstituents;each R7is independently selected from halo, CN, C1-6 alkyd, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-4 alkylidene-C3-7 cycloalkyl, C1-4 alkylidene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalky l, 5-6 membered heteroaryl, ORa7, C(O)Rb7. C(O)NRc7Rd7, C(O)ORa7, and NRc7Rd7, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Ci-4 alk lidene-C3-7 cycloalkyl, Ci-4 alkyhdene-4-7-membered heterocycloalkyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Ra7, Rc7. and Rd7is independently selected from H. C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each Rb7is independently selected from C1-6 alky l and C1-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Asubstituents;each R7Ais independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa71, C(O)Rb71, C(O)NRc71Rd71, C(O)ORa71, and NRc71Rd71;each Ra71, Rc71, and Rd71is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl and C1-6 haloalkyl are each optionally substituted with 1. 2, 3, or 4 independently selected R7Bsubstituents;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor, any Rc71and Rd71atached to the same N atom, together with the N atom to which they are atached, form a 4-7 membered heterocycloalkyl group, wherein the 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents;each Rb71is independently selected from Ci-6 alkyl and Ci-6 haloalkyl, which are each optionally substituted with 1, 2, 3, or 4 independently selected R7Bsubstituents; and each R7Bis independently selected from D, OH, CN, halo, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;Rwis selected from:L2is -C(O)-, -NR9C(O)-, -S(O)2-, or -NR9S(O)2-;provided that when L2is -C(O)- or -S(O)2- and Z is Cy1, then L2is attached to a nitrogen ring member of Cy1;R9is selected from H and C1-3 alkyl;R81and R82are each independently selected from H, halo, CN, C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, 5-6 membered heteroaryl-Ci-4 alkyl, and C(O)ORa8, wherein said C1-6 alkyl, C1-6 haloalky l. 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl-Ci-4 alkyl, and 5-6 membered heteroaiy l-C 1-4 alkyl are each optionally substituted by 1 or 2 substituents selected from halo, CN, C1-3 alkyl, C1-3 haloalkyl, OH, C1-3 alkoxy, C 1-3 haloalkoxy, C1-3 alkoxycarbonyl, amino, C1-3 alkylamino, and di(Ci-3 alkyl)amino;each Ra8is independently selected from H and C1-6 alkyl; andeach R10is independently selected from D, halo, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, ORa10, SRa10, C(O)Rb10, C(O)NRc10Rd10, C(O)ORa10, OC(O)Rb10, OC(O)NRc10Rd10, NRc10Rd10, NRc10C(O)Rb10, NRc10C(O)ORa10, NRc10C(O)NRc10Rd10, NRc10S(O)2Rb10, NRc10S(O)2NRc10Rd10, S(O)2Rb10, and S(O)2NRc10Rd10;each Ral°, Rcl°, and Rdl° is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; andeach Rb10is independently selected from C1-6 alkyl and C1-6 haloalkyl.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION 35. The compound of claim 1, wherein the compound is a compound of Formula (II):or a pharmaceutically acceptable salt thereof.

36. The compound of claim 1, wherein the compound is a compound of Formula (III):or a pharmaceutically acceptable salt thereof.

37. The compound of claim 1, wherein the compound is a compound of Formula (IV):or a pharmaceutically acceptable salt thereof.

38. The compound of claim 1, wherein the compound is a compound of Formula (V):Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; and v is 0 or 1.

39. The compound of claim 1, wherein the compound is a compound of Formula (VI):or a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; and v is 0 or 1.

40. The compound of claim 1, wherein the compound is a compound of Formula (VII):Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor a pharmaceutically acceptable salt thereof, wherein q is 0 or 1; and v is 0 or 1.

41. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)azetidine-l-carbonyl)phenyl)acrylamide;(S)-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)pyrrolidine- 1 -carbonyl)phenyl)acrylamide;rac-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)piperidine- 1 -carbonyl)phenyl)acrylamide;rac-N-(4-((2R,4S)-4-(7-(3.5-dichloro-4-hydroxyphenyl)-2H-[1.2.3]triazolo[4,5-c]pyridin-2-yl)-2-methylpyrrolidine-l-carbonyl)phenyl)acrylamide;(S)-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)py rrolidine- 1 -carbonyl)-2-methoxyphenyl)acrylamide;rac-N-(4-(3-(7-(3,5-dichloro-4-hydroxyphenyl)-3-(l-methyl-2-oxo-1.2-dihydropyridin-4-yl)-2H-pyrazolo|4,3-c]pyridin-2-yl)pyrrolidine-l-carbonyl)phenyl)acrylamide;N-(4-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)phenyl)acrylamide;l-(5-((7-(3.5-dichloro-4-hydroxyphenyl)-2H-[1.2.3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;rac-l-(5-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)isoindolin-2-yl)prop-2-en-l-one;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONl-(5-((4-(3,5-dichloro-4-hydroxyphenyl)-2H-pyrazolo[3,4-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-pyrazolo[4,3-c]pyridin-2-yl)methyl)isoindolin-2-yl)prop-2-en-l-one;(£)-2-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindoline-2-carbonyl)-4-methylpent-2-enenitrile;l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[L23]triazolo[4,5-c]pyridin-2-yl)methy l)isoindolin-2-y l)but-2-yn- 1 -one;l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-2-fluoroprop-2-en-l-one;CE)-l-(5-((7-(3?5-dichloro-4-hydroxyphenyl)-27f-[1.2.3]triazolo[4,5-c]pyri din-2-yl)methyl)isoindolin-2-yl)-4-(177-l,2,4-triazol-l-yl)but-2-en-l-one;(£)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-3-(pyridin-4-yl)prop-2-en-l-one;(E)-l-(5-((7-(3?5-dichloro-4-hydroxyphenyl)-27f-[1.2.3]triazolo[4,5-c]pyri din-2-yl)methy l)isoindolin-2-y l)-4,4,4-trifluorobut-2-en- 1 -one;(£)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methy l)isoindolin-2-yl)-4-hy droxybut-2-en- 1 -one;methyl (E)-4-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)-4-oxobut-2-enoate;(£)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-27f-pyrazolo[4,3-c]pyri din-2-yl)methyl)isoindolin-2-yl)-4,4-difluorobut-2-en-l-one;( y)-4-(azetidin-l-yl)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)isoindolin-2-yl)but-2-en-l-one:l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)prop-2-en-l-one;(£^-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5.7-dihydro-6H-pyrrolo[3,4-6]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;(£ -l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2 / / -[L23]triazolo[4,5-c]pyridin-2-yl)methyl)-5,7-dihydro-677-pyrrolo[3,4-6]pyridin-6-yl)-4-(piperidin-l-yl)but-2-en-l-one; l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-2H-[l,2,3]triazolo[4,5-c]pyri din-2-yl)methyl)-5.7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)prop-2-en-l-one; andCE)-l-(2-((7-(3?5-dichloro-4-hydroxyphenyl)-27f-[1.2.3]triazolo[4,5-c]pyri din-2-yl)methyl)-5,7-dihydro-677-pyrrolo[3,4-cf]pyrimidin-6-yl)-4-(piperidin-l-yl)but-2-en-l-one;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATIONor a pharmaceutically acceptable salt of any of the aforementioned.

42. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:rac-(E')-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / 7-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67 / -pyrrolo[3.4-6]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;(?, E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / 7-[l,2,3]triazolo[4,5-c]411yridine-2-yl)ethyl)-5,7-dihydro-677-pyrrolo[3,4-6]41 lyridine-6-yl)-4-(diethy lamino)but-2-en- 1 -one;(< S’,£)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67f-pyrrolo[3,4-6]pyridin-6-yl)-4-(diethylamino)but-2-en- 1-one;(E)-l-(2-(2-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / f-[l,2,3]triazolo[4,5-c] pyridin-2-yl)propan-2-yl)-5,7-dihy dro-67 / -py rrol o [3,4-b] py ridin-6-yl)-4-(dimethylamino)but-2-en- 1 -one;(. V,£)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / f-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-6 / f-pyrrolo[3,4-Z?]pyridin-6-yl)-4-(2,2-dimethylpyrrolidin-1 -y l)but-2-en- 1 -one;rac-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27f-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-3-fluoro-5,7-dihydro-677-pyrrolo[3,4-Z)]pyridin-6-yl)prop-2-en-l-one;(£ -l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)cyclobutyl)-5,7-dihydro-677-pyrrolo[3,4-b]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;rac-(E)-l-(2-(cyclopropyl(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-5,7-dihydro-6 / f-pyrrolo[3,4-b]pyridin-6-yl)-4-(dimethylamino)but-2-en- 1 -one;rac-(E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-2 / 7-[l,2,3]triazolo[4,5-c]pyridin- 2-yl)propan-2-yl)-5,7-dihydro-6 / -pyrrolo[3,4-b]pyridin-6-yl)-4-(diethylamino)but-2-en-l-one;rac-(E)-l-(2-(l-(4-amino-7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-6 / 7-pyrrolo[3,4-b]pyridin-6-yl)-4-(2,2-dimethylpyrrolidin-1 -y l)but-2-en- 1 -one;Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION(E)-7-(3,5-dichloro-4-hydroxyphenyl)-2-((6-(4-(diethylamino)but-2-enoyl)-3-methoxy-6,7-dihydro-57f-pyrrolo[3,4-b]pyridin-2-yl)methyl)-27 / -[l,2,3]triazolo[4.5-c]pyridine-4-carbonitrile;rac-(E)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(3-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-ethyl-27 / -| 1.2.3 |triazolo|4.5-c|pyridin-2-yl)ethyl)-2-methoxy-5.7-dihydro-6 / / -pyrrolo[3,4-d]pyridin-6-yl)but-2-en-l-one;rac-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methoxy-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-67f-pyrrolo[3,4-b]pyridin-6-yl)prop-2-en-l-one;rac-(E')-l-(2-(l-(6-chloro-7-(3,5-dichloro-4-hydroxyphenyl)-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-5,7-dihydro-6 / 7-pyrrolo[3,4-Z?]pyridin-6-yl)-4-(dimethylamino)but-2-en-l-one;(E)-l-(5-(2-(7-(2-chloro-6-methoxypyridin-4-yl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)propan-2-yl)indolin-l-yl)-4-(dimethylamino)but-2-en-l-one;(£)-4-(bis(methyl-d3)amino)-l-(5-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / 7-[l,2,3]triazolo[4.5-c]pyridin-2-yl)methyl)-4-fluoroindolin-l-yl)but-2-en-l-one;(E)-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-277-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-3-ethyl-5,7-dihydro-677-pyrrolo[3,4-6]pyridin-6-yl)-4-(piperi din-1-yl)but-2-en-l-one;(E)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(2-(2-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-2 / / -[l,2,3]triazolo[4.5-c]pyridin-2-yl)propan-2-yl)-4-methoxy-5,7-dihydro-6 / / -pyrrolo[3,4-Z?]pyridin-6-yl)but-2-en-l-one;(£)-4-(3-azabicyclo[3.1.1]heptan-3-yl)-l-(2-((7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-227-[l,2,3]triazolo[4,5-c]pyridin-2-yl)methyl)-3-methoxy-5,7-dihydro-67 / -pyrrolo[3,4-d]pyrazin-6-yl)but-2-en-l-one;n?c-(E)-l-(2-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-4-methoxy-5,7-dihydro-677-pyrrolo[3,4-d]pyrimidin-6-yl)-4-(piperidin-1 -y l)but-2-en- 1 -one;rac-(E)-l-(5-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-2,3-dihydro-17 / -pyrrolo[23-c]pyridin-l-yl)-4-(dimethylarnino)but-2-en-1 -one;(S,£)-l-(5-(l-(7-(3,5-dichloro-4-hydroxyphenyl)-4-methyl-27 / -[l,2,3]triazolo[4,5-c]pyridin-2-yl)ethyl)-2,3-dihydro-l / 7-pyrrolo[3,2-b]pyridin-l-yl)-4-(dimethylamino)but-2-en-l-one; andAttorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION(E)-l-(5-(2-(7-(2-chloro-6-methoxypyridin-4-yl)-4-methyl-27f-[l,2,3]triazolo[4,5-c]pyridin-2-yl)propan-2-yl)-2,3-dihydro-l#-pyrrolo[2,3-c]pyridin-l-yl)-4-(diethylamino)but-2-en-l-one;or a pharmaceutically acceptable salt of any of the aforementioned.

43. The compound of any one of claims 1-42, or a pharmaceutically acceptable salt thereof, wherein the compound is deuterated.

44. A pharmaceutical composition comprising the compound of any one of claims 1-43, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

45. A method of inhibiting VRK1, comprising contacting the VRK1 with the compound of any one of claims 1-43, or a pharmaceutically acceptable salt thereof.

46. A method of inhibiting VRK1 in a patient, comprising administering to the patient a compound of any one of claims 1-43, or a pharmaceutically acceptable salt thereof.

47. A method of selectively inhibiting VRK1 over VRK2, comprising contacting the VRK1 and VRK2 with a VRK1 inhibitor, or a pharmaceutically acceptable salt thereof.

48. A method of covalently binding a cysteine in VRK1 with a VRK1 inhibitor, or a pharmaceutically acceptable salt thereof.

49. The method of claim 48, further comprising binding with a water in the binding pocket of VRK1.

50. The method of claim 48 or 49, further comprising binding with Phel34 of VRK1.

51. The method of any one of claims 48-50, further comprising binding with Lys71 of VRK1.

52. The method of any one of claims 48-51, further comprising binding with Asp 132 of VRK1.Attorney Docket No. 20443-0895WO1 / INCY0578-WO1 UTILITY APPLICATION53. The method of any one of claims 48-52, further comprising binding with the phosphate-binding loop of VRK1.

54. The method of any one of claims 47-53, wherein the VRK1 inhibitor is a compound of any one of claims 1-43, or a pharmaceutically acceptable salt thereof.

55. A method of treating a disease or disorder associated with VRK1 in a patient, comprising administering to the patient a therapeutically effective amount of the compound of any one of claims 1-43, or pharmaceutically acceptable salt thereof.

56. The method of claim 55, wherein the disease or disorder is cancer.

57. The method of claim 56, wherein the cancer is sarcoma, colorectal adenocarcinoma, acute myeloid leukemia, glioblastoma, and neuroblastoma.

58. The method of claim 57, wherein the glioblastoma or neuroblastoma have overepression ofVRKl.

59. The method of claim 57, wherein the glioblastoma or neuroblastoma have underexpression of VRK2.

60. The method of claim 56, wherein the cancer is bone cancer, cancer of the neck and head, rectal cancer, esophageal cancer, sarcoma of soft tissue, neoplasm of the central nervous system (CNS), brain stem, glioma, colon cancer, Ewing’s sarcoma, brain cancer, astrocytoma, neuroblastoma, intestinal cancer, nervous system cancers, osteosarcoma, cancer of the small bowel, adenocarcinoma of the small bowel, lymphoma of the small bowel, carcinoid tumors of the small bowel, Kaposi’s sarcoma of the small bowel, leiomyoma of the small bowel, hemangioma of the small bowel, lipoma of the small bowel, neurofibroma of the small bowel, fibroma of the small bowel, cancer of the large bowel, adenocarcinoma of the large bowel, tubular adenoma of the large bowel, villous adenoma of the large bowel, hamartoma of the large bowel, or leiomyoma of the large bowel.

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