Roll-to-roll production device for immunochromatographic test strip uncut sheet

Abstract

Disclosed in the present invention is a roll-to-roll production device for an immunochromatographic test strip uncut sheet. The device comprises a constant-speed uncut sheet conveying component, a laminating unit, a drying unit, a solution coating unit, a material handling unit, a main conveying structure, and a main control unit. The constant-speed uncut sheet conveying component can match speeds of the laminating unit and the solution coating unit, so that an uncut sheet laminated with multiple materials can meet the requirements of constant-speed feeding and coating. The laminating unit can automatically laminate a plurality of roll-type film materials. The solution coating unit can automatically coat a detection solution. The drying unit can automatically dry a coated plastic backing. The material handling unit can cut the dried plastic backing into backing sheets according to a predetermined length or complete a winding operation. The device can implement functions such as automatic lamination of multiple materials, automatic coating of a detection solution after lamination, automatic material conveying, automatic drying of film materials, and automatic alignment correction and cutting.

Description

A large-scale roll production equipment for immunoassay test strips Technical Field

[0001] This technical solution mainly involves the fields of "automatic production technology of in vitro diagnostic test strips", "production technology of biological diagnostic test strips", and "automation control technology", and in particular, it relates to a large-plate roll production equipment for immunoassay test strips. Background Technology

[0002] In vitro diagnostic test strips are essential tools in the medical testing field, widely used in disease diagnosis, health monitoring, and many other areas. Traditional production methods for in vitro diagnostic test strips are mostly manual or semi-automated, resulting in low efficiency, high costs, and inconsistent quality. With the rapid development of in vitro diagnostic technology and the continuous expansion of market demand, higher requirements are being placed on the production efficiency and quality of test strips.

[0003] In existing technologies, the production of in vitro diagnostic test strips mainly relies on manual operation or simple mechanical assistance, which has the following shortcomings:

[0004] 1. Low production efficiency: Manual or semi-automated operations cannot achieve large-scale, continuous production, resulting in limited production efficiency and difficulty in meeting market demand for test strips.

[0005] 2. High cost: Manual operation requires a large amount of manpower and is prone to errors, resulting in high production costs.

[0006] 3. Unstable quality: Manual operation makes it difficult to guarantee the consistency and stability of each batch of test strips, affecting the accuracy of test results.

[0007] 4. Inability to automatically apply multiple materials: Existing technology cannot automatically apply multiple film materials to plastic sheets, especially the application of protective film strips to plastic sheets, which requires manual operation, resulting in low efficiency and a high risk of errors.

[0008] 5. Inability to automate solution coating: Existing technologies cannot automate the coating of biological solutions onto roll-to-roll plastic sheets, requiring manual operation, which is inefficient and prone to solution waste.

[0009] 6. Inability to achieve visual recognition for waste marking: Existing technology cannot achieve automatic detection and marking of test strip quality, requiring manual inspection, which is inefficient and prone to missed detection.

[0010] 7. Inability to automatically apply protective film: Existing technology cannot automatically apply protective film to test strips, requiring manual operation, which is inefficient and prone to errors.

[0011] 8. Inability to achieve automatic correction and cutting: Existing technology cannot achieve automatic correction and cutting of continuous plastic sheets, which requires manual operation, resulting in low efficiency and easy material waste.

[0012] In summary, existing technologies have many shortcomings in the production process of in vitro diagnostic test strips, making it difficult to meet market demands for high-efficiency, low-cost, and high-quality test strips. Therefore, developing an automated production equipment and method to achieve automatic plate bonding, solution coating, drying, visual identification of waste labels, protective film application, and automatic correction and cutting of roll-type multi-materials is of great significance for improving the production efficiency and quality of test strips. Summary of the Invention

[0013] Based on this, this technical solution mainly solves the following problems: 1) Low production efficiency of in vitro diagnostic test strips, making it impossible to achieve large-scale, continuous production and failing to meet market demand for test strips; 2) High production cost of in vitro diagnostic test strips, with manual operation requiring a large amount of manpower and prone to errors, resulting in high production costs; 3) Unstable quality of in vitro diagnostic test strips, with manual operation making it difficult to ensure the consistency and stability of each batch of test strips, affecting the accuracy of test results; 4) Existing technologies cannot achieve automatic plating of multiple materials, requiring manual operation, which is inefficient and prone to errors; 5) Existing technologies cannot achieve automated solution coating, requiring manual operation, which is inefficient and prone to solution waste; 6) Existing technologies cannot achieve visual identification of waste labels, requiring manual inspection, which is inefficient and prone to missed detections; 7) Existing technologies cannot achieve automatic application of protective films, requiring manual operation, which is inefficient and prone to errors; 8) Existing technologies cannot achieve automatic correction and cutting, requiring manual operation, which is inefficient and prone to material waste.

[0014] The purpose of this invention is to overcome the shortcomings of the prior art and provide a large-scale roll-type immunoassay test strip production equipment. This equipment features automatic multi-film material application, automatic roll-type plastic sheet coating, automatic identification of marked and discarded plastic sheet coating, and automatic correction and cutting of the plastic sheet.

[0015] To solve the above-mentioned technical problems, the objective of this invention is achieved as follows:

[0016] This invention provides a large-plate roll production equipment for immunoassay test strips, comprising a large-plate uniform conveying component, a plate bonding unit, a drying unit, a material handling unit, a main control unit, a solution coating unit, and a main conveying structure.

[0017] The plate-applying unit is located at the front end of the equipment and includes a first plate-applying component. The first plate-applying component includes a guide and limiting component, a buffer probe dual component, a large plate point backrest adjustment component, an unwinding component, and a pressing component. The buffer probe dual component can be combined with the guide and limiting component to realize that multiple other roll-type film materials are respectively applied to different positions on the plastic film plate with adhesive on the surface during the uniform speed conveying process.

[0018] Furthermore, the guide limiting component is placed behind the buffer probe dual component and adopts a single-sided open multi-roller limiting structure;

[0019] Furthermore, the buffer probe dual-component assembly is placed after the unwinding assembly and includes an adjustable gravity swing arm and a sensor, which can adjust the material tension force based on the position feedback of the swing arm.

[0020] Furthermore, the large plate point backing adjustment component is used for point-to-point limiting of rolled materials, wherein the single-side point is a limit block set in sequence, and the other side point is a multi-contact limit structure with a common propulsion structure, and the two sides cooperate to limit the material within a specific track;

[0021] Furthermore, the unwinding assembly includes a geared motor and a unwinding reel, which can be used for variable-speed unwinding of rolled materials such as plastic sheets, immunochromatographic membranes, and auxiliary materials;

[0022] Furthermore, the pressing assembly is placed after the guide limiting assembly and includes a pair of extrusion rollers, wherein a single roller can automatically adjust the extrusion pressure with the other roller, thereby completing the bonding of the roll material and the adhesive sheet;

[0023] In some embodiments, when multiple rolls of material need to be laminated, the first laminating component includes multiple sets of the guide limiting assembly, the buffer probe dual assembly, the large board point backing adjustment assembly, the unwinding assembly, and the pressing assembly.

[0024] The drying unit is located after the first plate component and includes a fresh air intake controller, an electric hot air assembly, a circulating fan, a temperature sensor, an exhaust assembly, a controller, and an oven body. It can adapt to the rapid drying of film materials under various coating conditions and can also realize functions such as hot air circulation heating and moisture alarm discharge of roll film materials.

[0025] Furthermore, the oven body is equipped with partitions to separate multiple areas: a fresh air and circulating air mixing chamber with a fresh air intake controller; a circulating air channel with a circulating fan; an airflow heating zone with an electric heating air assembly; and a drying zone with a temperature sensor.

[0026] Furthermore, the fresh air intake control can be set as a fresh air inlet valve or a fan, installed at the fresh air inlet, to adjust the fresh air intake.

[0027] Furthermore, the circulating fan is installed in the circulating air duct, and can mix the fresh air and return air according to the wind speed parameter value of the drying zone before delivering them into the airflow heating zone;

[0028] Furthermore, the electric heating device is installed on the partition in the heating zone, and the power of the electric heating device can be adjusted according to the airflow temperature value;

[0029] Furthermore, the exhaust assembly can be configured as an exhaust valve or an air outlet, which is connected to the drying area;

[0030] Furthermore, the friction elimination component adopts an active drive mode, which can eliminate the friction caused by multi-roller winding. Specifically, it can be a torque motor with a set torque less than the tensile force that the rolled material can withstand.

[0031] The main control unit is connected to the plate-mounting unit, the drying unit, and the material handling unit, and controls the movement of the plate-mounting unit, the drying unit, and the material handling unit.

[0032] The solution coating unit is located after the plate bonding unit and includes a solution conveying component and a large plate uniform speed conveying component.

[0033] Furthermore, the large plate uniform speed conveying component includes a main conveying structure and a material traction structure, which can control the conveying speed of the material before solution coating, so that the multiple materials after bonding meet the coating requirements.

[0034] Furthermore, the main control unit is connected to equipment units such as the large plate uniform speed conveying component and the plate attaching unit, and controls the actions of each actuator in the corresponding unit.

[0035] Furthermore, the main conveying structure includes a power assembly and an extrusion assembly, which can realize the active feeding of rolled materials;

[0036] Furthermore, the material traction structure includes a rotating shaft assembly driven by a motor; when the material traction structure uses a non-torque motor, it also includes a buffer assembly located between the rotating shaft assembly and the main conveying structure, used to adjust the speed difference between the main conveying structure and the material traction structure to prevent the material from being excessively pulled.

[0037] Furthermore, the solution delivery component includes a coating head assembly, a first adjustment assembly, and a second adjustment assembly. The coating head assembly can be positioned using the first and second adjustment assemblies. After being placed behind the first plate assembly, the solution delivery component can uniformly deliver the biological solution through a solution pipeline onto a continuously moving plastic plate, coating at least one hydrophilic membrane material. The solution coating can be in the form of lines, large-area wetting, or full-area wetting. The first adjustment assembly includes a coarse adjustment scale module and a fine adjustment screw head; the second adjustment assembly includes a coarse adjustment module and a fine adjustment screw head. The coating head assembly is located on the first adjustment assembly and can achieve automatic cleaning and spraying.

[0038] Furthermore, the coating head assembly includes a self-cleaning air nozzle and a solution non-contact spray head, which are arranged side by side. The self-cleaning air nozzle has a self-cleaning module that enables self-cleaning without disassembly, and the solution non-contact spray head is a steel needle that enables non-contact solution coating.

[0039] The large plate uniform speed conveying component is located between the plate bonding unit and the solution conveying component. It includes a main conveying structure and a material traction structure. It can control the conveying speed of the material before solution coating so that the multiple materials after bonding meet the coating requirements.

[0040] Furthermore, the main conveying structure includes a power assembly and an extrusion assembly, which can realize the active feeding of rolled materials;

[0041] Furthermore, the material traction structure includes a rotating shaft assembly driven by a motor; when the material traction structure uses a non-torque motor, it also includes a buffer assembly located between the rotating shaft assembly and the main conveying structure, used to adjust the speed difference between the main conveying structure and the material traction structure to prevent the material from being excessively pulled.

[0042] In some embodiments, the mounting unit further includes a second mounting component, which is disposed after the drying unit and before the material handling unit, and is suitable for mounting some materials that are not suitable for mounting in the process of the first mounting component; for example, in immunochromatographic test strips, the character protective film is attached to the surface of the sample pad or colloidal gold pad, and is attached after the solution encapsulated in the sample pad or gold pad has dried.

[0043] The second mounting component includes a pre-pressing assembly and an edge-wrapping assembly, which can realize the deviation-free feeding, flattening and edge-wrapping of materials such as protective film, and ultimately meet the requirements of edge-folding and bonding of roll materials with plastic sheets;

[0044] Furthermore, the edge-binding assembly includes a bending component and a secondary bending component, which can complete the bending and flanging of viscous materials. The bending component and the secondary bending component are symmetrically arranged and adjustable on one side to adapt to the production needs of large plates of different widths, and can complete the U-shaped flanging of roll tape. The pre-pressing assembly consists of rollers arranged symmetrically on the top and bottom and left and right, which can complete the initial extrusion and bonding of the rolled material after bending.

[0045] The material handling unit can be a winding component, which includes at least two sets of torque motors and a winding reel. When the tension exceeds the set value, the motor runs idle to avoid breaking the material.

[0046] Furthermore, the material handling unit can also be a cutting component, which can fix the rolled material and cut the material to a specific length; the winding component and the cutting component can be set separately or in combination as needed.

[0047] Another aspect of the present invention provides a method for producing large-plate rolls, comprising:

[0048] The bonding unit sequentially adheres various roll film materials to the plastic sheet, and the plastic sheet requiring edge wrapping is finished after being processed by the edge wrapping component.

[0049] Under the traction of the main conveying structure and the material traction structure, it reaches the lower end of the solution conveying component;

[0050] After the solution coating unit completes the solution coating, the plastic sheet is pulled to the visual waste marking unit to complete the visual identification and defect marking of the plastic sheet.

[0051] Afterwards, the plastic sheets are thoroughly dried in the drying unit;

[0052] An additional mounting plate component is added when a protective film needs to be applied.

[0053] Finally, the plastic sheet enters the material handling unit, where the roll material is collected by the winding component and cut into pieces of a specific length by the cutting component.

[0054] The beneficial effects of this invention are as follows: 1. Improved production efficiency: By integrating the plating unit, drying unit, and cutting components, this invention achieves automated production of in vitro diagnostic test strips, significantly improving production efficiency and output. 2. Enhanced product quality: The application of a visual waste labeling unit automatically identifies and marks products with morphological defects, thereby improving product quality and reliability. 3. Reduced production costs: Automated production reduces manual operation and labor costs. Simultaneously, precise control of the production process reduces material waste, further lowering production costs. 4. Enhanced production flexibility: The equipment of this invention can adjust the plating and coating patterns according to different production needs, adapting to the production of different types of test strips, thus enhancing production flexibility. 5. Improved environmental adaptability: The drying unit, through the coordinated operation of a fresh air controller, internal differential pressure gauge, heating device, temperature and humidity sensors, and humidity sensors, can adapt to environments with different humidity and temperature conditions, maintaining stable production conditions. 6. Optimized energy utilization: The radiant heat of the electrothermal film dries the moisture in the film material, improving energy utilization efficiency and reducing energy consumption. 7. Improved equipment stability: The design of the circulating fan and the internal circulating air differential pressure gauge ensures the uniformity of airflow inside the oven, improving the stability and reliability of the equipment. Attached Figure Description

[0055] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0056] Figure 1 is a schematic diagram of the structure of a large roll-type immunoassay test strip production equipment according to the present invention.

[0057] Figure 2 is a top view of a large roll-type production equipment for immunoassay test strips according to the present invention.

[0058] Figure 3 is a schematic diagram of the structure of the large plate uniform speed conveying component of the present invention;

[0059] Figure 4 is a front view of the first mounting plate component of the present invention;

[0060] Figure 5 is a structural schematic diagram of the first mounting plate component of the present invention;

[0061] Figure 6 is a schematic diagram of the solution delivery component of the present invention;

[0062] Figure 7 is a cross-sectional view of the structure of the air nozzle of the present invention;

[0063] Figure 8 is a schematic diagram of the structure of the visual waste marking unit of the present invention;

[0064] Figure 9 is a schematic diagram of the drying unit of the present invention;

[0065] Figure 10 is a schematic diagram of the structure of the correction component of the present invention;

[0066] Figure 11 is a schematic diagram of the structure of the cutting component of the present invention;

[0067] Figure 12 is a structural schematic diagram of the second mounting plate component of the present invention;

[0068] Figure 13 is a schematic diagram of the dual-component buffer probe of the present invention;

[0069] Figure 14 is a flowchart of the production method of the large roll of immunoassay test strips of the present invention. Detailed Implementation

[0070] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0071] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly.

[0072] Furthermore, the term "and / or" in the text includes three solutions. Taking A and / or B as an example, it includes technical solution A, technical solution B, and technical solution that simultaneously satisfies both A and B. In addition, the technical solutions of various embodiments can be combined with each other, but this must be based on the ability of a person skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0073] Example 1

[0074] As shown in Figures 1-12, this application provides a technical solution: a large-plate roll production equipment for immunoassay test strips, comprising:

[0075] Plate-mounting unit 10, drying unit 20, material handling unit 30, and main control unit 40:

[0076] In this embodiment, as shown in FIG1, the plate-applying unit 10 is placed at the front end of the equipment and includes a first plate-applying component 11. The first plate-applying component 11 is placed at the starting end of the equipment. The first plate-applying component 11 can apply multiple roll-type films to different positions on the plastic film plate with adhesive on the surface during the uniform speed conveying process.

[0077] Specifically, as shown in Figures 4 and 13, the first bonding component 11 includes an unwinding assembly 111, a drive roller 112, a buffer probe dual assembly 113, a guide and limit assembly 114, and a pressing assembly 115. The unwinding assembly 111 serves as the starting end. After unwinding, the material passes through the drive roller 112 and reaches the buffer probe dual assembly 113 under the drive of the traction belt. The buffer probe dual assembly 113 is positioned before the pressing assembly 115, which can adjust the material buffer margin and avoid excessive pulling or breakage during the material bonding process. The buffer probe dual assembly 113 includes an adjustable gravity swing arm 1131, a connecting shaft 1132, and a swing roller 1133. One end of the buffer probe dual assembly 113 is connected to... The device is equipped with a swing roller 1133 at one end and an adjustable gravity swing arm 1131 at the other end. The adjustable gravity swing arm 1131 is equipped with an adjustable gravity counterweight 11311 and a locking block 11312. The swing roller 1133 can swing back and forth within a specific range during its up and down movement. The guide limit assembly 114 is located between the buffer probe dual assembly 113 and the film pressing mechanism 115. It adopts a single-sided open multi-roller limit structure and is used for the correction of roll film. The pressing assembly 115 is placed on the device body 40 and can tightly press multiple roll film together. This structure can realize the bonding of at least two types of film onto a plastic sheet.

[0078] Specifically, as shown in Figure 12, the mounting unit 10 also includes a second mounting component 12, which is located after the drying unit 20 and before the cutting component 30. It is suitable for mounting materials that are not suitable for mounting in the first mounting component 11 process; for example, in immunochromatographic test strips, the protective film for characters on the surface of the sample pad or colloidal gold pad is attached after the solution encapsulated inside the sample pad or gold pad has dried. The second mounting component 12 includes an unwinding assembly 121, a pre-feeding mechanism 122, and a guide and limiting assembly 123. The pressing assembly 124 enables the unbiased feeding of materials such as protective films, ultimately achieving a tight fit with the dried plastic sheet. The dried plastic sheet reaches the bottom of the feeding roller 121, which actively feeds the material through the pre-feeding mechanism 122 to the guide and limit assembly 123. The guide and limit assembly 123 is located between the feeding roller 121 and the film pressing mechanism 124 and is used for correcting the deviation of the roll film. The pressing assembly 124 is placed on the equipment body 40 and can tightly press various roll films together.

[0079] In this embodiment, the drying unit 20 is placed after the first plate component 11. It can uniformly enter the oven with the roll film material coated with biological solution but not dried properly and the plastic sheet to be attached. After multiple passes of the rotating rollers at different positions, the biological solution of the film material is quickly dried under the action of hot air with certain pressure, speed and temperature, and then it is transported out by the drying unit 20.

[0080] Specifically, as shown in Figure 9, the drying unit 20 also includes a fresh air controller 21, an internal differential pressure gauge 22, a heating device 23, a temperature and humidity sensor 24, an exhaust port 26, a circulating fan 27, a wind speed sensor 25, and an electric heating film. The drying unit 20 is divided into a mixing zone, an airflow heating zone, and a drying zone by an internal partition. The rotation speed of the fresh air controller 21 is linked to the internal and external differential pressure gauges to maintain a set positive pressure value inside the chamber. The power of the heating device 23 is linked to the temperature and humidity sensor 24 to maintain the hot air temperature at a set temperature value, and the airflow is adjusted according to the value of the temperature and humidity sensor 24. When a damp membrane material enters the drying unit 20, the airflow... As humidity increases, the exhaust volume of the dehumidification port 26 is correlated with the humidity detection value to maintain the humidity of the hot air inside the chamber at the set value. The circulating air baffle is placed between the heating device and the circulating fan 27. The hot air in the drying unit 20 can flow back to the circulating air baffle through the upper cavity, thereby re-contacting the heating device 23 to achieve hot air circulation heating and circulation. The air outlet of the circulating fan 27 is equipped with a baffle to prevent the circulating air from directly contacting the membrane material. The wind speed sensor 25 is placed in the drying area and can provide feedback on the wind speed value based on the moisture level of the membrane material and the drying effect. The controller controls the ventilation volume of the fresh air controller 21 and the circulating fan 27. The electric heating film is set flush with the membrane material to improve the drying effect.

[0081] In this embodiment, the cutting component 30 is placed on the equipment body and is the last process of the equipment. It can push the continuous glue board coming out of the drying unit 20 forward according to the set length by the conveying roller and cut it into a large board of a certain length for multiple materials to be glued together.

[0082] Specifically, as shown in Figures 10-11, the cutting component 30 includes a correction component 31 and a cutting component 32. The correction component 31 is located at the front end and first contacts the plastic sheet to correct its deviation. The cutting component 32 is located at the rear end of the correction component and can cut the plastic sheet to a specific length. The correction component 31 includes two sensors 311, one roller 312, and two correction rollers 313. The sensors 311 are located behind the correction rollers and can feed back the identification signal to the correction rollers 313. The correction rollers 313 are located at the front end and can squeeze and convey the plastic sheet to the lower part of the sensors 311. The speed of the corresponding control motor can be adjusted to achieve differential correction of the material and ensure the accuracy of the final cutting.

[0083] In this embodiment, as shown in FIG6, the device body 40 further includes a solution delivery component 41. The solution delivery component 41 includes a coating head assembly 413, a first adjustment component 411, and a second adjustment component 412. The second adjustment component 412 is fixed on the device body 40 and can adjust the Z-direction position of the solution delivery component 41. The first adjustment component 411 is fixed to the top of the second adjustment component 412 and is used to adjust the Y-direction position of the coating head assembly 413 thereon. The coating head assembly 413 can be positioned and adjusted by the first adjustment component 411 and the second adjustment component 412. After the solution delivery component 41 is placed on the first plate component 11, it can uniformly deliver the biological solution through the solution pipeline to the continuously moving plastic plate and coat at least one hydrophilic membrane material. The solution coating can be in the form of lines, large-area wetting, or whole-area wetting.

[0084] Specifically, the first adjustment component 411 includes a coarse adjustment scale module 4111 and a fine adjustment screw head 4112; the coarse adjustment scale module 4111 is located on the second adjustment component 412 and can realize the approximate positioning of the coating head component 413 in the Y-axis direction, while the fine adjustment screw head 4112 can realize the accurate adjustment of the coating head component 413 in the Y-axis direction; the second adjustment component 412 includes a coarse adjustment module 4121 and a fine adjustment screw head 4122; the coarse adjustment module 4121 can realize the approximate positioning of the coating head component 413 in the Z-axis direction, while the fine adjustment screw head 4122 can realize the accurate adjustment of the coating head component 413 in the Z-axis direction; the coating head component 413 is located on the first adjustment component 411 and can realize automatic cleaning and spraying.

[0085] Specifically, the coating head assembly 413 is located on the first adjustment assembly 411. The coating head assembly 413 includes an air nozzle 4131 and a solution spray head 4132, which are arranged side by side. The top of the air nozzle 4131 has a self-cleaning module, which can achieve self-cleaning without disassembly. When the operation is completed or the spray solution needs to be replaced, air can be vented into the self-cleaning module to fully atomize the cleaning liquid at the top and clean the overall internal structure of the air nozzle 413. The bottom of the solution spray head 4132 is equipped with a steel needle. The steel needle can achieve non-contact division and also solve the problem of replacing the aging of traditional plastic solution tubes.

[0086] Specifically, the air nozzle 4131 has an additional opening near the compressed air inlet to allow another solution tube to be introduced into the airflow chamber. When internal cleaning is required, the compressed air and the solution from the other tube enter simultaneously from near the top. The gas and solution mix and clean the inner wall of the airflow chamber, thus easily eliminating cross-contamination.

[0087] In this embodiment, as shown in FIG3, the device body 40 is also provided with a large plate uniform speed conveying component 42. The large plate uniform speed conveying component 42 is located between the plate bonding unit 10 and the solution conveying component 41, and includes a main conveying structure 421 and a material traction structure 422. It can control the conveying speed of the material before solution coating so that the multiple materials after bonding meet the coating requirements.

[0088] Specifically, the main conveying structure 421 includes a power assembly 4212 and an extrusion assembly 4211, which can realize the active feeding of rolled materials;

[0089] Specifically, the material traction structure 422 includes a rotating shaft assembly 4221 driven by a motor; when the material traction structure uses a non-torque motor, it also includes a buffer assembly 4222, located between the rotating shaft assembly and the main conveying structure, used to adjust the speed difference between the main conveying structure 421 and the material traction structure 422 to prevent the material from being excessively pulled.

[0090] The specific material traction structure 422 can also be a continuous belt conveyor, which can drive the plastic sheet with multiple layers of film to move forward actively.

[0091] In this embodiment, as shown in FIG8, the equipment body 40 is also provided with a visual waste labeling unit 43. The visual waste labeling unit 43 is configured in the process after the solution conveying component 41 and before the drying unit 20. It can inspect the solution coating effect and record the position information of the plastic plate into the controller.

[0092] Specifically, the visual waste labeling unit 43 includes a visual component 431 and a waste labeling component 432. The visual component 431 is located at the front end of the waste labeling component 432. When the biological solution is coated on the surface of the hydrophilic membrane in the form of lines, the visual component 431 will detect the shape of the lines according to the set parameters. The waste labeling component 432 can label defects as waste.

[0093] Specifically, the waste marking component 432 includes a color-coded marker 4321 and a marker recognition device 4322. The marker 4321 is located at the front end of the marker recognition device 4322. The marker 4321 can be a pen or a printing device and can use the color marking line corresponding to the defect of the film material as the identification signal for waste. The marker recognition device 4322 is located to the right of the marker 4321 and can identify the marking line and provide feedback on whether the defect location is marked with the marking line.

[0094] The roll-type immunoassay test strip production equipment of this embodiment uses a bonding unit to sequentially bond roll-type membrane materials. Then, the roll-type membrane materials are coated with solution as required, and then the membrane materials are dried in a drying unit. After the protective film is bonded, the roll-type membrane materials are produced. Finally, the membrane materials are preliminarily cut by a cutting unit. This equipment can reduce production processes, improve production efficiency, and realize automated production of roll-type membrane materials.

[0095] Example 2

[0096] This application provides a technical solution: a large sheet roll to roll production equipment, which uses a winding module to replace the material handling unit 30 in Embodiment 1. After various film materials are pasted onto a plate to form a plastic sheet, the plastic sheet enters the solution conveying component 41 for solution coating. The coated and marked plastic sheet enters the drying unit 20, where it is fully dried. After drying, the plastic sheet passes through the second plate pasting component 12 to attach a protective film. Finally, the plastic sheet enters the winding module to complete the winding.

[0097] The large-plate roll-to-roll production equipment in this embodiment uses a winding module to replace the cutting component, which can realize automatic bonding, wrapping, drying, secondary protective film bonding, and winding of roll-type multi-materials. It has the advantages of high automation and reduced manual operation.

[0098] Example 3

[0099] This application also provides a technical solution: based on a conveyor belt-type solution coating platform;

[0100] Using the aforementioned roll-type coating structure, the material is then cut and conveyed to the conveyor belt-type solution coating platform, which can meet the needs of small-batch production or testing. Unlike the roll-type clamping feeding structure, this conveyor belt-type solution coating platform enables uniform material transport and, compared to the clamping structure, better protects the NC membrane material, preventing damage.

[0101] Example 4

[0102] This application also provides an embodiment of a large-plate roll production method: As shown in Figure 14, a large-plate roll production method includes the following steps:

[0103] Step S100: After the temperature inside the continuous oven reaches the predetermined temperature, the plate-mounting unit 10 attaches various roll film materials to the plastic adhesive plate. NC film, fiberglass film or other roll materials can be attached to the surface of the plastic adhesive plate.

[0104] Step S200: Under the traction of the material traction structure 42, the plastic sheet reaches the lower end of the solution conveying component 41 and passes through the solution conveying component 41 to enclose the solution to be tested;

[0105] Step S201: After the plastic sheet reaches the designated position, the second adjustment component 412 controls the wrapping head component 413 to descend, and at the same time adjusts the fine adjustment screw head 4122 according to the thickness of the plastic sheet to achieve the required wrapping height.

[0106] Step S202: After the plastic sheet reaches the designated position, the first adjustment component 411 adjusts the solution coating head component to the approximate position through the coarse adjustment scale module 4111, and then the coating head component 413 completes the adjustment through the fine adjustment screw head 4112.

[0107] Step S300: After the solution conveying component 41 completes the solution coating, the plastic sheet is pulled to the visual waste marking unit 43 to complete the visual identification, position marking and defect marking of the plastic sheet;

[0108] In step S301, the plastic sheet coated with the detection solution can be detected by the identification module 431 to detect the solution line. If the solution line is interrupted or aggregated, the identification module 431 will judge it as a coating abnormality.

[0109] Step S302: The abnormal signal will be transmitted to the scrapped component, and the scrapped component 432 will mark the corresponding defect location with a marking line through the marker 4321;

[0110] Step S303: The marking recognition device 4322 can identify whether the marking line exists, compare the defect location and feed back the signal to determine whether the marking line has been accurately marked.

[0111] Step S400: The plastic sheet with the coating mark enters the drying unit 20 and is thoroughly dried in the drying unit 20;

[0112] Step S401: After the material enters the drying unit 20, the fresh air controller 21 supplies fresh air at a constant speed. For example, the speed of the fresh air controller 21 is set to 1000 rpm and the air volume is 500 m³ / min. 3 / h;

[0113] Step S402: Fresh air is heated into stable hot air by heating device 23. For example, the heating temperature is set to 50°C;

[0114] Step S403: The bottom circulating fan 27 delivers hot air to the film drying area;

[0115] Step S404: The humidity sensor in the drying zone monitors the humidity in real time. When the humidity is lower than the warning value, the top moisture exhaust mechanism 26 is closed. Hot air passes through the top of the drying zone and enters the buffer zone. The differential pressure sensor 22 in the buffer zone controls the action of the lever. The hot air passes through the buffer zone and mixes with the hot air in the heating zone before re-entering the drying zone.

[0116] Step S405: When the humidity is higher than the warning value, the top moisture exhaust mechanism opens to exhaust moisture. At this time, the fresh air controller 21 and the circulating fan 27 increase their power to increase the air supply until the humidity drops below the warning value.

[0117] Step S406: During the hot air circulation process, the moisture discharge mechanism 26 of the buffer zone opens downward, and the hot air from the drying zone is introduced into the buffer zone and mixed with the hot air from the heating zone before re-entering the drying zone to achieve hot air circulation.

[0118] Step S500: After drying, the plastic sheet passes through the second board-attaching component 12 to attach a protective film, and finally the plastic sheet enters the cutting component 30;

[0119] Step S600: The plastic sheet is corrected in real time by the correction structure 31 to achieve position correction, and finally the precise length is cut.

[0120] Repeat the above steps until the roll film material completes the functions of mounting, wrapping, identification, labeling, drying and cutting.

[0121] The large-plate roll production method of this embodiment can realize automatic continuous plate bonding, sample solution coating, film scribing defect identification, defect marking and verification, automatic drying, and precise cutting. It can complete the plate bonding requirements of multiple film materials at a time. At the same time, it adopts a high-efficiency, energy-saving, circulating, and dehumidifying oven to avoid the waiting time caused by manual drying in the oven at a time. Finally, it can realize the cutting of the finished product test card, which can meet the requirements of uninterrupted, automated, efficient, and low-cost production.

[0122] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A large-plate roll production device for immunoassay test strips, comprising a solution coating unit, a plate-mounting unit, and a main control unit, characterized in that, The bonding unit is located at the front of the equipment and can guide, buffer, and bond multiple materials. The solution coating unit is located after the plate bonding unit and includes a solution conveying component and a large plate uniform speed conveying component. The large plate uniform speed conveying component includes a main conveying structure and a material traction structure, which can control the conveying speed of the material before solution coating, so that the multiple materials after bonding meet the coating requirements. The main control unit is connected to equipment units such as the large plate constant speed conveying component and the plate attaching unit, and controls the actions of each actuator in the corresponding unit.

2. The immunoassay test strip large-plate roll production equipment as described in claim 1, characterized in that, The main conveying structure includes a power component and an extrusion component, which can realize the active feeding of rolled materials; The material traction structure includes a rotating shaft assembly driven by a motor; when the material traction structure uses a non-torque motor, it also includes a buffer assembly located between the rotating shaft assembly and the main conveying structure, which is used to adjust the speed difference between the main conveying structure and the material traction structure to prevent the material from being excessively pulled.

3. The immunoassay test strip large-plate roll production equipment as described in claim 2, characterized in that, Also includes: The drying unit, located behind the first plate component, includes a fresh air intake controller, an electric heating air assembly, a circulating fan, a temperature sensor, an exhaust assembly, a controller, and an oven body. The material handling unit includes a winding component or a sheet cutting component. The winding component is located after the drying unit and includes a roll winding shaft to wind the dried roll material. The sheet cutting component can cut the roll film into sheets of a set length. in, The oven body is divided into multiple areas by partitions: a fresh air and circulating air mixing chamber with a fresh air intake controller; a circulating air channel with a circulating fan; an airflow heating zone with an electric heating air assembly; and a drying zone with a temperature sensor. The fresh air intake control can be set as a fresh air inlet valve or a fan, installed at the fresh air inlet, to adjust the fresh air intake. The circulating fan is installed in the circulating air duct and can mix fresh air and return air according to the wind speed parameter value of the drying area before delivering them into the airflow heating area. The electric heating device is installed on the partition in the heating zone, and the power of the electric heating device can be adjusted according to the airflow temperature value. The exhaust assembly can be configured as an exhaust valve or an air outlet, and it is connected to the drying zone; The friction elimination component adopts an active drive mode, which can eliminate the friction caused by multi-roller winding. Specifically, it can be a torque motor, with the set torque being less than the tensile force that the rolled material can withstand. The main control unit is connected to the plate-mounting unit, the drying unit, and the material handling unit, and controls the movement of the plate-mounting unit, the drying unit, and the material handling unit.

4. The immunoassay test strip large-plate roll production equipment as described in claim 3, characterized in that, It also includes, A solution delivery component, comprising a coating head assembly, a first adjustment assembly, and a second adjustment assembly, wherein the coating head assembly can be positioned by the first adjustment assembly and the second adjustment assembly, and the coating head assembly includes a self-cleaning air nozzle and a solution non-contact spray nozzle; The solution conveying component is placed after the large plate uniform speed conveying component, and at least one hydrophilic membrane material can be coated. The solution coating can be in the form of lines, large-area wetting, or whole-area wetting. The first adjustment component includes a coarse adjustment scale module and a fine adjustment screw head; The second adjustment component includes a coarse adjustment module and a fine adjustment screw head; The coating head assembly is located on the first adjustment assembly and can realize automatic cleaning and spraying.

5. The immunoassay test strip large-plate roll production equipment as described in claim 4, characterized in that, The self-cleaning air nozzle and the non-contact spray nozzle are arranged side by side. The air nozzle has a self-cleaning module that can achieve self-cleaning without disassembly. The bottom of the spray nozzle is equipped with a steel needle that can achieve non-contact solution line coating.

6. The immunoassay test strip large-plate roll production equipment as described in claim 1, characterized in that, The plate-mounting unit includes a first plate-mounting component, which includes a guide and limiting assembly, a buffer probe dual assembly, a large plate point backrest adjustment assembly, an unwinding assembly, and a pressing assembly. The guide limiting component is placed behind the buffer probe dual component and adopts a single-sided open multi-roller limiting structure. The buffer probe dual-component assembly is placed after the unwinding assembly and includes an adjustable gravity swing arm and a sensor, which can adjust the material tension force based on the swing arm position feedback. The large plate backing adjustment component is used for point-to-point limiting of rolled materials. The single-side points are sequentially arranged limiting blocks, and the other side points are multi-contact limiting structures with a common propulsion structure. The two sides work together to limit the material within a specific track. The unwinding assembly includes a geared motor and a unwinding reel, and can be used for variable-speed unwinding of rolled materials such as plastic sheets, immunochromatographic membranes, and auxiliary materials; The pressing assembly is positioned behind the guide limiting assembly and includes a pair of extrusion rollers, wherein a single roller can automatically adjust the extrusion pressure with the other roller, thereby completing the bonding of the roll material and the adhesive sheet; When multiple roll materials need to be laminated, the first laminating plate component includes multiple sets of guide and limiting components, buffer probe dual components, large plate point backing adjustment components, unwinding components, and pressing components.

7. The immunoassay test strip large-plate roll production equipment as described in claim 6, characterized in that, The bonding unit also includes a second bonding component, which includes a pre-pressing component and an edge-wrapping component. This component can achieve deviation-free feeding, flattening and edge wrapping of materials such as protective film, ultimately satisfying the edge-folding and bonding of roll materials with plastic sheets. The edge-binding component includes a bending component and a secondary bending component, which can complete the bending and flanging of viscous materials. The bending component and the secondary bending component are symmetrically arranged and adjustable on one side to adapt to the production needs of large plates of different widths. It can complete the U-shaped flanging of roll tape. The pre-compression assembly consists of rollers arranged symmetrically on the top and bottom and left and right, which can complete the initial compression and bonding of rolled materials after bending.

8. The immunoassay test strip large-plate roll production equipment as described in claim 1, characterized in that, Also includes: The material handling unit may be a winding component, which includes at least two sets of torque motors and a take-up reel. When the tension exceeds the set value, the motor runs idle to avoid breaking the material. The material handling unit may also be a cutting component, which can fix the rolled material and cut the material to a specific length at the same time; The winding component and the cutting component can be set individually or in combination as needed.

9. A method for producing large-plate rolls of immunoassay test strips, applied to any one of the large-plate roll production equipment described in 1 to 8, characterized in that, include: The bonding unit sequentially adheres various roll film materials to the plastic sheet, and the plastic sheet requiring edge wrapping is finished after being processed by the edge wrapping component. Under the traction of the main conveying structure and the material traction structure, it reaches the lower end of the solution conveying component; After the solution delivery component completes the solution coating, the plastic sheet is pulled to the visual waste marking unit to complete the visual identification and defect marking of the plastic sheet; Afterwards, the plastic sheets are thoroughly dried in the drying unit; An additional mounting plate component is added when a protective film needs to be applied. Finally, the plastic sheet enters the material handling unit, where the roll material is collected by the winding component and cut into pieces of a specific length by the cutting component.

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