Sample analyzer and control method therefor

Abstract

The present application is applicable to the field of medical devices, and discloses a sample analyzer and a control method therefor. The sample analyzer comprises a first sample storage component, a second sample storage component, a first transfer component, a sample dispensing component, a nucleic acid extraction component, a pipetting component, an amplification detection component and a controller, wherein a first accommodating position is formed in the first sample storage component, and the first accommodating position is used for placing a single sample container loaded with a sample to realize loading; and a second accommodating position is formed in the second sample storage component, the second accommodating position is used for placing a carrying component carrying sample containers loaded with samples to realize loading of the samples, a plurality of container positions are formed in the carrying component, and each container position is used for placing a single sample container. The present application can meet the requirement for rapid loading and testing of individual and urgent samples on the sample analyzer.

Description

Sample Analyzer and its Control Method Technical Field

[0001] This application relates to the field of medical devices, and more particularly to a sample analyzer and a control method for the sample analyzer. Background Technology

[0002] The application of rapid nucleic acid testing for respiratory pathogens in outpatient and emergency departments is of significant clinical importance for the timely treatment of infected groups such as children, the elderly, patients with chronic diseases, pregnant women, and immunocompromised individuals. Respiratory pathogen nucleic acid samples from outpatient and emergency departments are characterized by non-centralized collection times, random sample arrival, and scattered samples. These characteristics are particularly pronounced in emergency department samples collected at night. To reduce the risk of respiratory infectious disease transmission within hospitals and to ensure timely medication guidance based on respiratory pathogen nucleic acid test results, strict time requirements are placed on the reporting of respiratory pathogen nucleic acid tests, such as within 2 hours. Therefore, samples collected from patients need to be tested immediately for rapid results.

[0003] In related technologies, respiratory pathogen nucleic acid testing is performed using integrated molecular diagnostic machines or molecular diagnostic point-of-care testing (POCT) instruments. However, neither integrated molecular diagnostic machines nor molecular diagnostic POCT instruments can meet the demand for rapid nucleic acid testing of respiratory pathogens in emergency departments at night, for the following reasons:

[0004] 1) Given the irregular sample collection times and random sample arrivals at night, laboratory departments typically assign one operator to work night shifts. This operator is responsible for handling multiple tests on various analyzers, such as those for complete blood count, biochemistry, immunology, coagulation, and molecular diagnostics. They are also responsible for reviewing test results and handling any abnormalities during testing. Therefore, the workload for night shift operators is quite heavy. Furthermore, the sample handling methods differ between analyzers, especially for respiratory pathogen nucleic acid samples, which requires a high level of expertise. Some on-duty operators lack sufficient experience, and the urgent and demanding nature of nighttime testing further complicates matters. Operators without molecular diagnostic testing expertise often struggle to independently handle respiratory pathogen nucleic acid samples. Therefore, few hospitals currently offer nighttime respiratory pathogen nucleic acid testing.

[0005] 2) The molecular diagnostic integrated machine provided by the relevant technology uses a dedicated emergency rack (which can hold multiple sample containers) for emergency samples. Operators need to open the lids of the sample containers inside a biosafety cabinet before placing them in the rack, and check that the sample barcodes are not obscured to prevent them from being unreadable during machine use. Respiratory pathogen nucleic acid samples pose a certain risk of infection, and operators increase their own risk of infection when opening the containers. To reduce the frequency of operations, operators generally wait until a sufficient number of emergency samples have been collected (e.g., enough to fill a single emergency rack) before opening the containers. Furthermore, the molecular diagnostic integrated machine uses a nucleic acid extraction plate with multiple wells for nucleic acid extraction and an amplification reaction plate with multiple wells for amplification detection. This molecular diagnostic integrated machine is mainly used for batch nucleic acid extraction and batch amplification detection of multiple samples. For emergency samples collected at night, if nucleic acid extraction is delayed until all wells of a nucleic acid extraction plate are filled with samples, and amplification is delayed until all wells of an amplification detection plate are filled with nucleic acid extraction solution, the report processing time for most respiratory pathogen nucleic acid tests will far exceed the stipulated time. Conversely, if nucleic acid extraction begins with only a few wells filled with samples, and amplification begins with only a few wells filled with nucleic acid extraction solution, it leads to waste of both extraction and reaction plates, resulting in a significant increase in testing costs. Therefore, this molecular diagnostic instrument cannot meet the rapid detection needs for respiratory pathogen nucleic acids at night.

[0006] 3) The molecular diagnostic POCT instruments provided by related technologies involve numerous manual operation steps and are time-consuming, requiring operators to manually process each sample. This includes preparing reagent cartridges according to sample volume, manually adding reagents and samples to the cartridges, assigning corresponding numbers to the sample containers and reagent cartridges, and subsequently viewing the test results by number and manually entering them into the LIS system. This molecular diagnostic POCT instrument suffers from high operator workload, long testing times, and risks of operator infection and result mismatch. Therefore, this molecular diagnostic POCT instrument is also insufficient to meet the rapid detection needs for respiratory pathogen nucleic acids at night. Summary of the Invention

[0007] The first objective of this application is to provide a sample analyzer that addresses the technical problem that sample analyzers in the related art are difficult to apply for rapid nucleic acid detection of respiratory pathogens at night.

[0008] To achieve the above objectives, the solution provided in this application is: a sample analyzer, comprising a first sample storage component, a second sample storage component, a sample dispensing component, a nucleic acid extraction component, a pipetting component, an amplification and detection component, and a controller, wherein:

[0009] The first sample storage component has a first accommodating position, which is used to place a single sample container loaded with a sample to realize the feeding of the sample;

[0010] The second sample storage component has a second accommodating position, which is used to place a carrier component loaded with a sample container and the sample container loaded with a sample to realize the feeding of the sample. The carrier component has multiple container positions, each of which is used to place a single sample container.

[0011] The controller is configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample, which is located in the first sample storage component, and to dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the liquid in the amplification reaction container, which contains at least the nucleic acid extract; and output the detection result of the sample based on the detection information fed back by the amplification detection component.

[0012] The controller is further configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample and originating from the second sample storage component, and to dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acid from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the liquid in the amplification reaction container, which contains at least the nucleic acid extract; and output the detection result of the sample based on the detection information fed back by the amplification detection component.

[0013] A second objective of this application is to provide a sample analyzer comprising a first sample storage component, a second sample storage component, a first transfer component, a sample dispensing component, a nucleic acid extraction component, a pipetting component, an amplification and detection component, and a controller, wherein:

[0014] The first sample storage component is used to place a sample container containing the sample to achieve sample loading;

[0015] The second sample storage component is used to place a sample container containing a sample to load the sample; the detection priority of the sample from the first sample storage component is higher than the detection priority of the sample from the second sample storage component;

[0016] The controller is configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container originating from the first sample storage component and dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and output the detection result of the sample based on the detection information fed back by the amplification detection component.

[0017] The controller is further configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container of the second sample storage component and dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least made from the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and output the detection result of the sample based on the detection information fed back by the amplification detection component.

[0018] The controller is further configured to: control the first transfer component to transfer the sample container from the second sample storage component and satisfying a first preset rule to the first sample storage component for recycling; and control the first transfer component to transfer the sample container from the first sample storage component and satisfying a second preset rule to the second sample storage component for recycling.

[0019] A third objective of this application is to provide a control method for a sample analyzer, the method comprising: controlling a sample dispensing component to aspirate at least a portion of a sample from a sample storage component having a first accommodating position for placing a single sample container containing a sample, and dispensing all or part of the aspirated sample into a nucleic acid extraction container; controlling a nucleic acid extraction component to extract nucleic acids from a liquid in the nucleic acid extraction container at least composed of the sample, to obtain a nucleic acid extract; controlling a pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; controlling an amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and outputting the detection result of the sample based on the detection information fed back by the amplification detection component;

[0020] The control method further includes: controlling the sample dispensing component to aspirate at least a portion of the sample from a sample container of a second sample storage component having a second accommodating position for placing a carrier component and the carrier component having multiple container positions, each container position for placing a single sample container, and dispensing all or part of the aspirated sample into a nucleic acid extraction container; controlling the nucleic acid extraction component to extract nucleic acid from a liquid in the nucleic acid extraction container made from at least the sample to obtain a nucleic acid extract; controlling the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container to an amplification reaction container; controlling the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and outputting the detection result of the sample based on the detection information fed back by the amplification detection component.

[0021] The sample analyzer and its control method provided in this application load single samples by setting up a first sample storage component for placing a single sample container loaded with samples; and load batch samples by setting up a second sample storage component for placing a carrier component capable of loading multiple sample containers. This allows the sample analyzer to simultaneously have channels for loading single samples and channels for loading batch samples, thus meeting the sample loading needs in different scenarios. Since samples loaded from the first sample storage component do not need to wait for a certain number of samples to be collected, it is beneficial for meeting the need for rapid testing of scattered and urgent samples, especially suitable for rapid testing of scattered emergency samples at night, thereby helping to solve the problem of difficulty in conducting nucleic acid testing in hospitals at night. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0023] Figure 1 is a front view schematic diagram of the sample analyzer provided in an embodiment of this application;

[0024] Figure 2 is a schematic diagram of the internal structure of the sample analyzer provided in the embodiment of this application;

[0025] Figure 3 is a schematic diagram showing the distribution of the first sample storage component, the second sample storage component, the buffer seat, and the sample suction seat provided in an embodiment of this application;

[0026] Figure 4 is a schematic diagram of the first sample storage component provided in the embodiment of this application being in the first open position of the first sample holder;

[0027] Figure 5 is a schematic diagram of the first sample storage component provided in the embodiment of this application being in the first closed position of the first sample holder;

[0028] Figure 6 is a schematic diagram showing the connection between the controller and the first trigger control, the second trigger control, the first power component, the second power component, and the display screen provided in an embodiment of this application;

[0029] Figure 7 is a schematic diagram of the structure of the second consumable storage component, the first reagent storage component, and the second reagent storage component provided in the embodiments of this application;

[0030] Figure 8 is a schematic diagram of the functional area distribution of the nucleic acid extraction component provided in an embodiment of this application;

[0031] Figure 9 is a schematic diagram of the distribution of amplification detection channels within the amplification detection component provided in the embodiments of this application;

[0032] Figure 10 is a three-dimensional schematic diagram of the first sample storage component, the second sample storage component, the identification component, the buffer seat and the sample suction seat provided in another embodiment of this application;

[0033] Figure 11 is a top view of Figure 10;

[0034] Figure 12 is a schematic diagram of the main interface provided in an embodiment of this application when the first sample storage component is idle;

[0035] Figure 13 is a schematic diagram of the main interface provided in an embodiment of this application when a sample container is placed in the first sample storage component;

[0036] Figure 14 is a schematic diagram of the first interface provided in an embodiment of this application;

[0037] Figure 15 is a schematic diagram of the second interface provided in an embodiment of this application.

[0038] Reference numerals in the attached diagrams are as follows: 10. Sample analyzer; 100. First sample storage component; 110. First sample holder; 111. Holder body; 112. First baffle; 113. First accommodating position; 120. First power unit; 130. Second baffle; 200. Second sample storage component; 210. Second sample holder; 211. Second accommodating position; 220. Second power unit; 300. Nucleic acid extraction component; 310. Lysis zone; 320. Washing zone; 321. First sub-washing zone; 322. Second sub-washing zone; 330. Drying zone; 340. Elution zone; 400. Amplification and detection component; 410. Amplification and detection channel; 411. First type of detection channel; 412. Second type of detection channel; 413. Detection slot; 500. Sample suction holder; 510. Sample suction position; 600. Buffer holder; 610. Buffer position; 611. 612. First buffer hole; 700. Second buffer hole; 710. Display screen; 720. First interface; 730. Second interface; 730. Main interface; 800. First consumable storage component; 900. Second consumable storage component; 101. First reagent storage component; 102. Second reagent storage component; 103. First trigger control; 104. Second trigger control; 105. Body; 1051. Faceplate; 1052. First opening; 106. Pipetting component; 107. Sample dispensing component; 108. Identification component; 109. First transfer component; 1001. Controller; 1002. Second transfer component; 20. Carrying component; 21. Sample rack; 22. Basket; 23. Container position; 30. Sample container; 40. Nucleic acid extraction container; 41. Nucleic acid extraction well; 50. Amplification reaction container; 51. Amplification reaction well. Detailed Implementation

[0039] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0040] The solutions provided in this application are applicable to analyzers used for nucleic acid extraction and amplification detection of samples, and are particularly suitable for analyzers used for nucleic acid extraction and amplification detection of samples collected from humans or animals. Unless otherwise specified, this application describes human samples as an example.

[0041] Referring to Figures 1 and 2, a first aspect of this application provides a sample analyzer 10, which is a molecular diagnostic integrated machine. Specifically, the sample analyzer 10 includes a first sample storage component 100, a second sample storage component 200, a sample dispensing component 107, a nucleic acid extraction component 300, a pipetting component 106, an amplification detection component 400, and a controller 1001 (as shown in Figure 6). The first sample storage component 100 is used to place a sample container 30 (as shown in Figure 10) containing a sample to achieve sample loading. The second sample storage component 200 is used to place a sample container 30 containing a sample to achieve sample loading. The first sample storage component 100 and the second sample storage component 200 are two independent sample loading channels, that is, the first sample storage component 100 and the second sample storage component 200 are not the same storage component. The sample can be loaded into the sample analyzer 10 by loading it into the first sample storage component 100, or it can be loaded into the sample analyzer 10 by loading it into the second sample storage component 200. The sample dispensing component 107 is used to aspirate at least a portion of the sample from the sample container 30 of the first sample storage component 100 and dispense all or part of the aspirated sample into the nucleic acid extraction container 40; and the sample dispensing component 107 is also used to aspirate at least a portion of the sample from the sample container 30 of the second sample storage component 200 and dispense all or part of the aspirated sample into the nucleic acid extraction container 40, that is, samples from both the first sample storage component 100 and the second sample storage component 200 can be aspirated for nucleic acid extraction and amplification detection. The nucleic acid extraction component 300 is used to extract nucleic acid from the liquid in the nucleic acid extraction container 40, which is at least composed of the sample, to obtain a nucleic acid extract. The pipetting component 106 is used to transfer the nucleic acid extract in the nucleic acid extraction container 40 into the amplification reaction container 50. The amplification detection component 400 is used to perform amplification reaction and detection on the liquid in the amplification reaction container 50, which contains at least the nucleic acid extract. The controller 1001 is configured to output the detection results of the sample based on the detection information fed back by the amplification detection component 400. The nucleic acid extraction component 300 is mainly used to extract nucleic acids from the sample to obtain purified nucleic acids. The amplification and detection component 400 is mainly used to amplify the nucleic acids extracted by the nucleic acid extraction component 300 to significantly increase the amount of nucleic acids in a short period of time, and to detect the amplified test solution. This implementation scheme obtains a test solution by extracting and amplifying nucleic acids from the sample, and then detects the test solution to obtain the test results of the sample, thereby meeting the needs of nucleic acid detection for respiratory pathogens.

[0042] In one implementation, the controller 1001 is configured to: control the sample dispensing component 107 to aspirate at least a portion of the sample from the sample container 30 containing the sample and from the first sample storage component 100, and to dispense all or part of the aspirated sample into the nucleic acid extraction container 40; control the nucleic acid extraction component 300 to extract nucleic acids from the liquid in the nucleic acid extraction container 40, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component 106 to transfer the nucleic acid extract from the nucleic acid extraction container 40 into the amplification reaction container 50; control the amplification detection component 400 to perform amplification reaction and detection on the liquid in the amplification reaction container 50, which contains at least the nucleic acid extract; and output the detection result of the sample based on the detection information fed back by the amplification detection component 400. The controller 1001 is further configured to: control the sample dispensing component 107 to aspirate at least a portion of the sample from the sample container 30 containing the sample and originating from the second sample storage component 200, and to dispense all or part of the aspirated sample into the nucleic acid extraction container 40; control the nucleic acid extraction component 300 to extract nucleic acids from the liquid in the nucleic acid extraction container 40, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component 106 to transfer the nucleic acid extract from the nucleic acid extraction container 40 into the amplification reaction container 50; control the amplification detection component 400 to perform amplification reaction and detection on the liquid in the amplification reaction container 50, which contains at least the nucleic acid extract; and output the detection results of the sample based on the detection information fed back by the amplification detection component 400. The sample analyzer 10 provided in this embodiment is a molecular diagnostic integrated machine that can automatically perform sample dispensing, nucleic acid extraction, and amplification detection.

[0043] Referring to Figure 3 and in conjunction with Figure 1, in one embodiment, the first sample storage component 100 has a first accommodating position 113, which is used to place a single sample container 30 (as shown in Figure 10) containing a sample to achieve sample loading. The second sample storage component 200 has a second accommodating position 211, which is used to place a carrier component 20 containing a sample container 30 and a sample in the sample container 30 to achieve sample loading. The carrier component 20 has a plurality of container positions 23, each container position 23 being used to place a single sample container 30. The first sample storage component 100 is mainly used for placing samples in the sample container 30 to achieve the loading of scattered samples; the second sample storage component 200 is mainly used for placing samples in the carrier component 20 to achieve the loading of batch samples. In this way, the sample analyzer 10 has both a channel for loading single samples and a channel for loading batch samples, thereby meeting the sample loading needs in different scenarios. For example, batch routine samples during the day can be loaded through the second sample storage component 200, while scattered emergency and outpatient samples during the day, as well as scattered samples at night, can be loaded through the first sample storage component 100, which can help meet the rapid detection needs of respiratory pathogen nucleic acids.

[0044] In one implementation, samples from the first sample storage unit 100 have a higher detection priority than samples from the second sample storage unit 200. That is, samples loaded later from the first sample storage unit 100 can be prioritized for aspiration, nucleic acid extraction, and amplification testing before samples loaded earlier from the second sample storage unit 200. This allows samples loaded later from the first sample storage unit 100 to obtain test results faster than samples loaded earlier from the second sample storage unit 200, thus enabling the first sample storage unit 100 to meet the needs of rapid loading and testing of emergency and outpatient samples, as well as scattered samples at night.

[0045] Referring to Figure 3 and in conjunction with Figures 1 and 2, in one embodiment, the sample analyzer 10 further includes a sample holder 500 and a first transfer member 109, the sample holder 500 having a sample suction position 510. The first transfer member 109 is used at least to transfer the sample container 30 (shown in Figure 10) from the first sample storage member 100 to the sample suction position 510. Before the controller 1001 (shown in Figure 6) controls the sample dispensing member 107 to aspirate at least a portion of the sample from the sample container 30 containing the sample from the first sample storage member 100, the controller 1001 is also configured to control the first transfer member 109 to transfer the sample container 30 containing the sample from the first sample storage member 100 to the sample suction position 510. The aforementioned sample dispensing component 107 aspirates at least a portion of the sample from the sample container 30 containing the sample from the first sample storage component 100 and dispenses all or part of the aspirated sample into the nucleic acid extraction container 40. This includes: the sample dispensing component 107 aspirating at least a portion of the sample from the sample container 30 located at the aspiration position 510 from the first sample storage component 100 and dispensing all or part of the aspirated sample into the nucleic acid extraction container 40. The aspiration seat 500 is independently configured from the first sample storage component 100. In molecular diagnostic integrated machines prior to this application, emergency samples were generally loaded using a dedicated emergency rack (similar to a sample rack 21 that can hold multiple sample containers 30), and the sample containers 30 were transported to the aspiration position 510 for aspiration using the emergency rack. This resulted in the emergency loading channel being occupied until all sample containers 30 in the emergency rack had been aspirated, which was very detrimental to the rapid testing needs of outpatient samples, emergency samples, and scattered samples at night. In this implementation scheme, when a sample is loaded from the first sample storage component 100, the first transfer component 109 first transfers the sample container 30 from the first sample storage component 100 to the suction position 510, which is independent of the first sample storage component 100. Then, the sample dispensing component 107 aspirates the sample from the sample container 30 located at the suction position 510. That is, the aspiration of the sample container 30 from the first sample storage component 100 is not performed at the first sample storage component 100, but is performed by transferring it from the first sample storage component 100 to the suction position 510. This facilitates the rapid release of the first sample storage component 100, so that the first sample storage component 100 can quickly enter the state for placing the next sample. This is beneficial to meet the needs of continuous rapid testing of scattered and urgent samples, especially suitable for rapid testing of scattered samples at night, thereby helping to solve the problem of difficulty in conducting nucleic acid testing in hospitals at night.

[0046] In one implementation, before the controller 1001 controls the sample dispensing component 107 to aspirate at least a portion of the sample from the sample container 30 containing the sample from the second sample storage component 200, the controller 1001 is further configured to control the first transfer component 109 to transfer the sample container 30 containing the sample from the second sample storage component 200 to the aspiration position 510. In this embodiment, the sample container 30 from the second sample storage component 200 and the sample container 30 from the first sample storage component 100 share the same aspiration position 510 for aspiration, which simplifies the structure of the sample analyzer 10 and reduces the working stroke of the sample dispensing component 107. Of course, in specific applications, as an alternative implementation, the sample container 30 from the second sample storage component 200 and the sample container 30 from the first sample storage component 100 can be transferred to two different sampling positions 510 for sampling. For example, the first transfer component 109 can be controlled to transfer the sample container 30 from the first sample storage component 100 to the first sampling position 510, and the first transfer component 109 can be controlled to transfer the sample container 30 from the second sample storage component to the second sampling position 510; or, the sample container 30 from the second sample storage component 200 can also be directly sampled in the second sample storage component 200 without needing to transfer the sample container 30 from the second sample storage component 200 to other positions for sampling.

[0047] In one implementation, the first transfer component 109 includes a single robotic arm, meaning that the same robotic arm is used for transferring sample containers 30 at different locations within the sample analyzer 10, thus simplifying the structure of the sample analyzer 10. Of course, in specific applications, as an alternative implementation, the first transfer component 109 may also include at least two robotic arms, each used to transfer sample containers 30 in different areas. For example, the first robotic arm is used to transfer sample containers 30 from the first sample storage component 100, and the second robotic arm is used to transfer sample containers 30 from the second sample storage component 200.

[0048] In one implementation, the sample dispensing component 107 includes a single sample needle, meaning that in the sample analyzer 10, the same sample needle is used to aspirate samples from both the sample container 30 of the first sample storage component 100 and the sample container 30 of the second sample storage component 200. This simplifies the structure of the sample analyzer 10. Of course, in specific applications, as an alternative implementation, one sample needle can be used to aspirate samples from the sample container 30 of the first sample storage component 100, and another sample needle can be used to aspirate samples from the sample container 30 of the second sample storage component 200.

[0049] Referring to Figure 3 and in conjunction with Figures 1 and 2, in one embodiment, the sample analyzer 10 further includes a buffer holder 600, which has buffer positions 610. The controller 1001 (see Figure 6) controls the first transfer member 109 to transfer the sample container 30 (see Figure 10) from the first sample storage member 100 and containing the sample to the aspiration position 510. This includes: the controller 1001 controlling the first transfer member 109 to first transfer the sample container 30 from the first sample storage member 100 to the buffer position 610 for buffering, and then transferring the sample container 30 from the buffer position 610 to the aspiration position 510. That is: before controlling the first transfer member 109 to transfer the sample container 30 from the first sample storage member 100 and containing the sample to the aspiration position 510, the controller first controls the first transfer member 109 to first transfer the sample container 30 from the first sample storage member 100 to the buffer position 610 for buffering. The buffer holder 600 is mainly used to buffer the sample container 30 to be aspirated. In this embodiment, the first transfer component 109 first transfers the sample container 30 from the first sample storage component 100 to the buffer position 610 for buffering, and then transfers it from the buffer position 610 to the sampling position 510 for sampling. This can help to further speed up the release of the first sample storage component 100, so that the first sample storage component 100 can enter the state of being filled with the next sample container 30 more quickly. This is more conducive to meeting the needs of continuous and rapid testing of scattered and urgent samples and scattered samples at night.

[0050] In one implementation, the sample holder 500 and the buffer holder 600 are two independent components. Of course, in specific applications, as an alternative implementation, the sample holder 500 and the buffer holder 600 can also be integrated into a single component, with sample placement positions 510 and buffer positions 610 formed in different areas of this component.

[0051] In one implementation, the controller 1001 controls the first transfer component 109 to transfer the sample container 30 containing the sample from the second sample storage component 200 to the sampling position 510, including: the controller 1001 controls the first transfer component 109 to first transfer the sample container 30 from the second sample storage component 200 to the buffer position 610 for buffering, and then transfer the sample container 30 from the buffer position 610 to the sampling position 510. In this embodiment, the first transfer component 109 first transfers the sample container 30 from the second sample storage component 200 to the buffer position 610 for buffering, and then transfers it from the buffer position 610 to the aspiration position 510 for aspiration. In this way, a certain number of sample containers 30 from the second sample storage component 200 can be buffered by the buffer seat 600. This allows the buffer seat 600 to still provide sample containers 30 for aspiration to the sample dispensing component 107 when the operator loads and / or unloads the sample containers 30 from the second sample storage component 200. This facilitates the feeding of materials into the second sample storage component 200 without shutting down the sample analyzer 10, thereby reducing downtime losses of the sample analyzer 10 and increasing the detection throughput of the sample analyzer 10.

[0052] Referring to Figures 3 and 10, in one embodiment, the first sample storage component 100 has at least two first accommodating positions 113, each first accommodating position 113 for placing a single sample container 30 containing a sample. In this embodiment, the first sample storage component 100 can accommodate at least two sample containers 30 at a time to achieve the loading of at least two samples. Of course, in specific applications, as an alternative embodiment, the first sample storage component 100 may also have only one first accommodating position 113.

[0053] In one implementation, the buffer seat 600 has at least two buffer positions 610, each buffer position 610 for placing a single sample container 30 to achieve buffering of the sample container 30. The number of buffer positions 610 is greater than or equal to the number of first accommodating positions 113. The controller 1001 controls the first transfer component 109 to transfer the sample container 30 containing the sample from the first sample storage component 100 to the aspiration position 510, including: the controller 1001 controls the first transfer component 109 to first transfer all the sample containers 30 located in the first sample storage component 100 to the buffer position 610 for buffering, and then transfer the sample containers 30 one by one from the buffer position 610 to the aspiration position 510. In this embodiment, before aspirating the sample from the first sample storage component 100, all the sample containers 30 on the first sample storage component 100 are first transferred to the buffer seat 600 for buffering. This facilitates faster release of the first sample storage component 100 to meet the need for continuous and rapid feeding of the first sample storage component 100, which is especially beneficial for rapid and continuous testing of samples at night.

[0054] In one implementation, the first sample storage component 100 forms two first accommodating positions 113. The first sample storage component 100 can accommodate two sample containers 30 at a time to load two samples. When both first container positions 23 are occupied by sample containers 30, the controller 1001 first controls the first transfer component 109 to transfer the sample container 30 located in one first accommodating position 113 to a buffer position 610 for buffering. Then, the controller 1001 controls the first transfer component 109 to transfer the sample container 30 located in the other first accommodating position 113 to another buffer position 610 for buffering. Finally, the controller 1001 controls the first transfer component 109 to transfer the sample containers 30 located in the two buffer positions 610 one by one to the aspiration position 510 for aspiration. This facilitates rapid release of the first sample storage component 100. Of course, in specific applications, the number of first accommodating positions 113 provided by the first sample storage component 100 is not limited to this; for example, it can also be three, four, five, or more.

[0055] In one implementation, the cache socket 600 forms three cache bits 610. This satisfies the requirement that the number of cache bits 610 formed by the cache socket 600 is greater than or equal to the number of first accommodating bits 113 formed by the first sample storage component 100, while also preventing the cache socket 600 from becoming too large. Of course, in specific applications, the number of cache bits 610 formed by the cache socket 600 is not limited to this; for example, it can also be two, four, five, or more.

[0056] In one implementation, the first receiving position 113 is equipped with an adapter. The adapter can accommodate sample containers 30 of different sizes and / or types, reducing the need for operators to transfer samples to another sample container 30. For example, the sample container 30 can be a blood collection tube or a virus tube. The adapter allows the first receiving position 113 to hold both blood collection tubes and virus tubes, thereby expanding the applicability of the sample analyzer 10. Blood collection tubes are used to collect venous blood samples, while virus tubes are used to collect respiratory samples such as throat swabs and nasal swabs.

[0057] Referring to Figures 10 and 11, in one embodiment, the buffer position 610 includes a first buffer hole 611 and a second buffer hole 612 with a diameter larger than that of the first buffer hole 611. When the sample container 30 is a blood collection tube, the first buffer hole 611 is used for inserting the blood collection tube to buffer it; when the sample container 30 is a virus tube, the second buffer hole 612 is used for inserting the virus tube to buffer it. In this embodiment, the buffer seat 600 can simultaneously meet the buffering requirements of both blood collection tubes and virus tubes, thereby expanding the applicability of the sample analyzer 10.

[0058] In one implementation, the two first accommodating positions 113 are also used to place a first quality control container containing a positive quality control sample and a second quality control container containing a negative quality control sample, respectively, during quality control item testing, to achieve the loading of positive and negative quality control samples; the first transfer component 109 is also used to transfer the first and second quality control containers from the first sample storage component 100 to the aspiration position 510, respectively, so that the sample dispensing component 107 can aspirate and dispense the positive and negative quality control samples. In terms of quality control testing, since two quality control samples (positive and negative quality control samples) need to be tested daily, the setting of the two first accommodating positions 113 also facilitates the placement of the first quality control container containing the positive quality control sample and the placement of the second quality control container containing the negative quality control sample into the first sample storage component 100 for loading at one time, thereby simplifying the loading operation of positive and negative quality control samples.

[0059] Referring to Figure 10 and in conjunction with Figures 2 and 6, in one embodiment, the sample analyzer 10 further includes an identification component 108, which is used to identify the sample container 30 from the first sample storage component 100 or the second sample storage component 200. The controller 1001 is also configured to: based on the information fed back by the identification component 108 regarding the identification of the sample container 30, acquire at least the detection item information of the samples in the sample container 30 from the first sample storage component 100 or the second sample storage component 200. In this embodiment, the sample analyzer 10 can automatically identify the sample container 30 to obtain the detection item information of the samples in the sample container 30, which has a high degree of automation and helps to reduce errors and omissions. Of course, in specific applications, the detection item information of the samples in the sample container 30 can also be implemented by manual input.

[0060] In one implementation, the sample analyzer 10 also includes an identification position. Before the controller 1001 controls the first transfer component 109 to transfer the sample container 30, which contains the sample from the first sample storage component 100, to the aspiration position 510, the controller 1001 is further configured to: control the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 to the identification position, and control the identification component 108 to identify the sample container 30 located at the identification position to obtain the detection item information of the sample in the sample container 30. Before the controller 1001 controls the first transfer component 109 to transfer the sample container 30, which contains the sample from the second sample storage component 200, to the aspiration position 510, the controller 1001 is further configured to: control the first transfer component 109 to transfer the sample container 30 from the second sample storage component 200 to the identification position, and control the identification component 108 to identify the sample container 30 located at the identification position to obtain the detection item information of the sample in the sample container 30. In this embodiment, the identification position is set independently of the first sample storage component 100, the second sample storage component 200 and the sample suction position 510. This facilitates the setting of the identification component 108 and helps to reduce the interference of other structural components on the identification process.

[0061] In one implementation, the identification component 108 includes at least one of a scanner and a vision camera. The identification component 108 is used to identify an identification code on the sample container 30, which includes at least one of a barcode, a QR code, and a radio frequency code.

[0062] In one implementation, the identification component 108 is used to identify the rotating sample container 30. After the first transfer component 109 transfers the sample container 30 to the identification position, the first transfer component 109 drives the sample container 30 to rotate at the identification position, so that the identification code on the sample container 30 rotates into the visible area of ​​the scanner or vision camera, thereby improving the identification success rate. Of course, in specific applications, after the first transfer component 109 transfers the sample container 30 to the identification position, the sample container 30 can also remain stationary, while the scanner or vision camera rotates around the sample container 30 located at the identification position, so that the visible area of ​​the scanner or vision camera rotates to be directly opposite the identification code on the sample container 30.

[0063] In one implementation, after the controller 1001 controls the identification unit 108 to identify the sample container 30 located at the identification position and obtains the detection item information of the sample in the sample container 30, the controller 1001 is further configured to: control the first transfer unit 109 to transfer the sample container 30 located at the identification position to the buffer position 610 for caching. Specifically, the sample container 30 from the first sample storage unit 100 is first transferred by the first transfer unit 109 to the identification position for identification. After successful identification (i.e., obtaining the detection item information of the sample in the sample container 30), it is then transferred by the first transfer unit 109 to the buffer position 610 for caching, and finally transferred by the first transfer unit 109 to the sampling position 510 for sampling. The sample container 30 from the second sample storage component 200 is first transferred by the first transfer component 109 to the identification position for identification. After successful identification, it is then transferred by the first transfer component 109 to the buffer position 610 for buffering, and finally transferred by the first transfer component 109 to the sampling position 510 for sampling. This facilitates the rapid release of the first sample storage component 100. In this embodiment, after the sample container 30 is identified and successfully identified, it is first buffered in the buffer position 610, and then transferred from the buffer position 610 to the sampling position 510 for sampling.

[0064] Of course, in specific applications, as an alternative implementation, after the sample container 30 is identified and successfully identified, the controller 1001 can also first determine whether the sampling position 510 is empty. If the sampling position 510 is empty, the first transfer component 109 can directly transfer the successfully identified sample container 30 from the identification position to the sampling position 510 without first caching it in the buffer position 610. Specifically, in this alternative implementation, after the controller 1001 controls the identification unit 108 to identify the sample container 30 located at the identification position and obtains the detection item information of the sample in the sample container 30, the controller 1001 is further configured to: when the sampling position 510 is vacant, control the first transfer unit 109 to transfer the sample container 30 located at the identification position to the sampling position 510; when the sampling position 510 is occupied, control the first transfer unit 109 to first transfer the sample container 30 located at the identification position to the buffer position 610 for buffering, and wait for the sampling position 510 to become vacant before transferring the sample container 30 from the buffer position 610 to the sampling position 510. Here, "vacant sampling position 510" specifically means that there is no sample container 30 in the sampling position 510, that is, the sampling position 510 is in an idle state.

[0065] In the above scheme, both the sample container 30 from the first sample storage component 100 and the sample container 30 from the second sample storage component 200 are first identified and then cached in the cache position 610. Of course, in specific applications, as an alternative implementation scheme, the sample container 30 from the first sample storage component 100 can also be cached in the cache position 610 first, and then from the cache position 610 to the identification position for identification. After successful identification, it can be cached in the cache position 610 again or directly to the sampling position 510 for sampling. Similarly, the sample container 30 from the second sample storage component 200 can also be cached in the cache position 610 first, and then from the cache position 610 to the identification position for identification. After successful identification, it can be cached in the cache position 610 again or directly to the sampling position 510 for sampling.

[0066] In one implementation, the controller 1001 is further configured to: if, based on the information fed back by the identification unit 108 regarding the sample container 30 from the first sample storage unit 100, the detection item information of the sample in the sample container 30 from the first sample storage unit 100 cannot be obtained, then control the first transfer unit 109 to place the sample container 30 back onto the first sample storage unit 100 for collection and processing by the operator. Specifically, for sample containers 30 from the first sample storage unit 100 that fail to be identified, i.e., the detection item information of the sample in the sample container 30 from the first sample storage unit 100 cannot be obtained, the first transfer unit 109 transfers the unidentified sample container 30 to the first sample storage unit 100 for collection and processing. Furthermore, since sample containers 30 from the first sample storage component 100 are only transferred to the buffer position 610 and the sampling position 510 after successful identification, the first transfer component 109 does not need to transfer unidentified sample containers 30 to the buffer position 610 for caching, and then transfer the unidentified sample containers 30 back to the first sample storage component 100, thereby reducing unnecessary transfer workload for the first transfer component 109. In this embodiment, if a sample container 30 from the first sample storage component 100 fails to be identified (i.e., the detection item information of the sample in the sample container 30 cannot be obtained), it is recycled by the first sample storage component 100. This allows operators to quickly process the unidentified sample container 30, such as manually entering the detection item information or the identification code information of the sample in the sample container 30.

[0067] If the controller 1001 cannot obtain the detection item information of the sample in the sample container 30 based on the information fed back by the identification component 108, it determines that there is an identification anomaly in the sample container 30. Identification anomalies mainly include the following situations: (1) there is no identification code on the sample container 30; (2) the sample container 30 has an identification code, but the code is contaminated or damaged, resulting in unsuccessful identification; (3) the sample container 30 has an identification code, but the code is not associated with detection item information; (4) there is a communication anomaly between the sample analyzer 10 and the LIS system (Laboratory Information System), preventing the download of detection item information from the LIS system. For these anomalies, operators can manually supplement the identification code or sample detection item information by referring to the sample container 30 or the requisition form for rapid recovery.

[0068] In the prior art, after determining that the sample container 30 had an abnormality in which the detection item information could not be obtained, the abnormal sample container 30 was transferred to the regular feeding channel (i.e., the second sample storage component 200) for recycling. When the operator needed to find and handle the abnormal sample container 30, he / she needed to locate the abnormal sample container 30 in the second sample storage component 200 according to the rack number of the sample rack 21, find the corresponding abnormal sample container 30 on the sample rack 21, and also check the abnormality cause on the interface according to the information of the sample container 30. The operation was very troublesome and would affect the normal detection of samples in the second sample storage component 200. Since there are sample containers 30 with identification anomalies, operators can quickly process them in the sample analyzer 10 to eliminate the anomalies. Therefore, in this embodiment, sample containers 30 with identification anomalies are retrieved from the emergency loading channel (first sample storage component 100). That is, the first sample storage component 100 used for emergency sample loading is reused for the retrieval of sample containers 30 with identification anomalies. This reduces the number of steps required for users to manually locate the abnormal sample containers 30, and allows operators to quickly process sample containers 30 with identification anomalies.

[0069] Of course, in specific applications, as an alternative implementation, regardless of whether the sample container 30 is successfully identified, the first transfer component 109 can be controlled to transfer the identified sample container 30 to the cache position 610 for caching. When the first sample storage component 100 is idle, the first transfer component 109 can then be controlled to transfer the unidentified sample container 30 cached in the cache position 610 to the first sample storage component 100 for recycling. In this alternative implementation, after the controller 1001 controls the identification component 108 to complete the identification of the sample container 30 located in the identification position, the controller 1001 is further configured to: control the first transfer component 109 to transfer the sample container 30 located in the identification position (including the sample container 30 that has obtained the sample detection item information and the sample container 30 that cannot obtain the sample detection item information) to the cache position 610 for caching.

[0070] In one implementation, the controller 1001 is further configured to: if, based on the information from the identification feedback of the identification component 108 regarding the sample container 30 from the second sample storage component 200, the detection item information of the sample in the sample container 30 from the second sample storage component 200 cannot be obtained, then control the first transfer component 109 to transfer the sample container 30 to the first sample storage component 100 for retrieval and processing by the operator. In this implementation, if the sample container 30 from the second sample storage component 200 fails to be identified, it is retrieved and processed by the first sample storage component 100. This allows the operator to quickly process the unidentified sample container 30 without requiring the operator to manually search for the sample container 30 on the second sample storage component 200, saving time and effort, increasing the degree of automation, and effectively avoiding the undesirable phenomenon of mistakenly picking up the wrong sample container 30 due to errors in the manual search process when there are too many sample containers 30 in the second sample storage component 200.

[0071] Of course, in specific applications, as an alternative implementation, if the sample container 30 from the second sample storage component 200 fails to be identified, it can also be recycled and processed by the second sample storage component 200. In this alternative implementation, the controller 1001 is also configured to: if the detection item information of the sample in the sample container 30 from the second sample storage component 200 cannot be obtained based on the information fed back by the identification component 108 on the identification of the sample container 30 from the second sample storage component 200, then control the first transfer component 109 to put the sample container 30 back into the second sample storage component 200 for the operator to recycle and process.

[0072] Referring to Figure 4 and in conjunction with Figures 1, 5, and 6, in one embodiment, the sample analyzer 10 further includes a body 105. A first sample storage component 100 includes a first sample holder 110 and a first power component 120. The first sample holder 110 has at least one first receiving position 113. The first power component 120 is drively connected to the first sample holder 110 to drive the first sample holder 110 to move relative to the body 105 between a first open position and a first closed position. Referring to Figure 4, when the first sample holder 110 is in the first open position, the first receiving position 113 is located outside the body 105, allowing the operator to place and retrieve the sample container 30. Referring to Figure 5, when the first sample holder 110 is in the first closed position, the first receiving position 113 is located inside the body 105, allowing the first transfer component 109 to retrieve and place the sample container 30. In this embodiment, the first sample storage component 100 is an electrically operated drawer-type structure. The first power component 120, under the control of the controller 1001, can drive the first sample holder 110 to move between a first open position and a first closed position, thereby opening and closing the first sample storage component 100 and improving the automation level of the sample analyzer 10. Of course, in specific applications, the configuration of the first sample storage component 100 is not limited to this. For example, as an alternative embodiment, the first sample storage component 100 can also be configured as a manually operated drawer-type structure, or it can be configured as a drawer-type structure that can be both electrically and manually controlled, or it can be configured as a structure that can be opened by flipping a lid or opening a door.

[0073] In one implementation, after an operator places at least one sample container 30 onto the first sample holder 110 located in the first open position, the controller 1001 is further configured to: control the first power unit 120 to drive the first sample holder 110 from the first open position to the first closed position; and control the first power unit 120 to drive the first sample holder 110 from the first closed position to the first open position after the first transfer unit 109 has removed all the sample containers 30 from the first sample holder 110 located in the first closed position, or after the identification unit 108 has completed the identification of all the sample containers 30 from the first sample holder 110 located in the first closed position. In this implementation, the first sample holder 110 located in the first closed position moves from the first closed position to the first open position under the drive of the first power unit 120 after all the sample containers 30 have been removed or identified, thereby realizing the automatic ejection of the first sample holder 110, which is beneficial to meet the need for rapid and continuous testing of scattered and urgent samples.

[0074] In one implementation, after the operator places at least one sample container 30 on the first sample holder 110 located in the first open position each time, the controller 1001 is further configured to: control the first power component 120 to drive the first sample holder 110 to move from the first open position to the first closed position; control the first transfer component 109 to transfer the sample container 30 on the first sample holder 110 located in the first closed position to the identification position for identification by the identification component 108; and, based on the information fed back by the identification component 108 regarding the identification of the sample container 30 from the first sample holder 110, obtain the detection item information of the samples in all sample containers 30 from the first sample holder 110, control the first power component 120 to drive the first sample holder 110 to move from the first closed position to the first open position.

[0075] In one implementation, the controller 1001 is further configured to: if it is impossible to obtain detection item information for at least one sample from the sample container 30 on the first sample holder 110 at the first closed position, first control the first transfer component 109 to place at least one sample container 30 back onto the first sample holder 110 at the first closed position, and then control the first power component 120 to drive the first sample holder 110 from the first closed position to the first open position, awaiting retrieval and processing by the operator. In this embodiment, if the sample container 30 from the first sample storage component 100 fails to be identified, it will automatically pop out from the first sample holder 110 for quick processing by the operator.

[0076] In one implementation, the controller 1001 is further configured to: if the detection item information of at least one sample from the sample container 30 of the second sample storage component 200 cannot be obtained, control the first transfer component 109 to return at least one sample container 30 to the second sample storage component 200 for operator retrieval; or first control the first transfer component 109 to transfer at least one sample container 30 to the first sample holder 110 located in the first closed position, and then control the first power component 120 to drive the first sample holder 110 from the first closed position to the first open position for operator retrieval. In this embodiment, if the sample container 30 from the second sample storage component 200 fails to be identified, it is automatically ejected from the first sample holder 110 for quick operator processing.

[0077] Referring to Figure 4 and in conjunction with Figures 1 and 5, in one embodiment, the body 105 includes a face shell 1051, which has a first opening 1052; the first sample holder 110 includes a seat body 111 and a first baffle 112, and the first sample storage component 100 further includes a second baffle 130; the seat body 111 has at least one first receiving position 113; the first baffle 112 can switch between a first state and a second state under the drive of the first power component 120. In the first state, the first baffle 112 closes the first opening 1052, and in the second state, the first baffle 112 avoids the first opening 1052; the second baffle 130 can switch between a third state and a fourth state under the drive of the first power component 120. In the third state, the second baffle 130 avoids the first opening 1052, and in the fourth state, the second baffle 130 closes the first opening 1052. When the first sample holder 110 is in the first open position, the first baffle 112 is in the first state, and the second baffle 130 is in the third state; when the first sample holder 110 is in the first closed position, the first baffle 112 is in the second state, and the second baffle 130 is in the fourth state. Both the first baffle 112 and the second baffle 130 can close the first opening 1052, ensuring good sealing of the first sample holder 110 in both open and closed states. This helps to isolate the internal and external spaces of the sample analyzer 10, thus ensuring a stable pressure difference; it also helps to reduce the escape of potentially contaminated gases from inside the sample analyzer 10 through the first opening 1052 into the external environment, thereby reducing the risk of contamination to the laboratory and operators. Furthermore, the first baffle 112 and the second baffle 130 share the same power component, saving one power component and simplifying the structure and reducing the cost of the sample analyzer 10. Of course, in specific applications, as an alternative implementation, the first baffle 112 and the second baffle 130 can also be driven by two independent power components.

[0078] In one implementation, the first power component 120 includes a motor, a first transmission mechanism, and a second transmission mechanism. The motor drives the first transmission mechanism to move the seat 111 of the first sample holder 110 and the first baffle 112 linearly along the guide rail. The first sample holder 110 drives the second baffle 130 to rotate via the second transmission mechanism, thereby achieving the effect of simultaneously driving the first baffle 112 and the second baffle 130 with a single motor. Of course, in specific applications, the arrangement of the first power component 120 is not limited to this.

[0079] In one implementation, the sample analyzer 10 further includes a cap-opening component; the cap-opening component is at least used to perform a cap-opening action on the sample container 30 from the first sample storage component 100 under the control of the controller 1001, so as to realize automatic cap-opening of the sample container 30 from the first sample storage component 100. The sample container 30 includes a container body and a cap, the cap being used to close and open the top opening of the container body. The cap-opening component performs the cap-opening action on the sample container 30 specifically by opening the cap to open the top opening of the container body.

[0080] In one embodiment, the opening component is also used to perform an opening action on the sample container 30 from the second sample storage component 200 under the control of the controller 1001, so as to realize the automatic opening of the sample container 30 from the second sample storage component 200.

[0081] In one implementation, the opening component and the first transfer component 109 are the same component, which simplifies the structure of the sample analyzer 10. Of course, in specific applications, as an alternative implementation, the opening component and the first transfer component 109 can also be two independent components.

[0082] As one implementation, before the control sample dispensing component 107 draws at least a portion of the sample from the sample container 30 located at the aspiration position 510, the controller 1001 is further configured to control the capping component to perform an opening action on the sample container 30. In related technologies prior to this application, before emergency samples are loaded onto the machine, operators need to manually open the cap, which is cumbersome, requires a high level of expertise from the operators, and is prone to infection. In this implementation, by providing a capping component for automatically opening the sample container 30 in the sample analyzer 10, operators can directly place the sample container 30 containing emergency or nighttime samples into the first sample storage component 100 for loading, without any processing of the sample container 30 containing emergency or nighttime samples. This greatly simplifies the sample loading operation steps for operators, reduces the professional requirements for operators, and reduces the risk of infection for operators themselves.

[0083] In one implementation, after the controller 1001 controls the identification unit 108 to identify the sample container 30 located at the identification position and obtains the detection item information of the sample in the sample container 30, and before controlling the sample dispensing unit 107 to draw at least a portion of the sample from the sample container 30, the controller 1001 is further configured to control the opening unit to perform an opening action on the sample container 30. In this embodiment, the opening action is performed after the sample container 30 is successfully identified, thus reducing unnecessary opening actions performed on sample containers 30 that fail to be identified.

[0084] In one implementation, when an operator places a sample container 30 in the first sample storage component 100 or when information is received that a sample container 30 is being fed from the first sample storage component 100, the controller 1001 is further configured to: control the identification component 108 to pause the identification of sample containers 30 from the second sample storage component 200 that have not yet begun identification, and control the capping component to pause the capping action of sample containers 30 from the second sample storage component 200 that have not yet begun the capping action. This is to first control the identification component 108 to identify the sample container 30 placed by the operator in the first sample storage component 100, control the capping component to perform the capping action of the sample container 30 placed by the operator in the first sample storage component 100, and control the sample dispensing component 107 to aspirate at least a portion of the sample from the sample container 30 placed by the operator in the first sample storage component 100 and located at the aspiration position 510, and to dispense all or part of the aspirated sample into the nucleic acid extraction container 40. In this implementation scheme, when a sample container 30 is fed from the first sample storage component 100, the sample container 30 fed from the first sample storage component 100 before it has started the opening action can be identified, opened and sampled first. That is, the sample fed from the first sample storage component 100 can jump the queue for the sample fed from the second sample storage component 200 before it, thereby facilitating the rapid detection of scattered and urgent samples.

[0085] In one implementation, the controller 1001 obtains information that a sample container 30 is being loaded from the first sample storage component 100 through at least one of the following methods: (1) The sample analyzer 10 includes a first trigger control 103 (see Figures 1 and 10). The first trigger control 103 is used by an operator to trigger the first sample holder 110 to move from the first open position to the first closed position. When the operator places the sample container 30 on the first sample storage component 100 and operates the first trigger control 103 to trigger the first sample holder 110 to move from the first open position to the first closed position, The controller 1001 obtains information that a sample container 30 is being fed from the first sample storage component 100 based on the feedback information from the first trigger control 103; (2) The sample analyzer 10 also includes an in-situ sensor, which is used to detect whether the first accommodating position 113 is loaded with a sample container 30. When the operator places the sample container 30 on the first sample storage component 100, the in-situ sensor is triggered and sends trigger information to the controller 1001. The controller 1001 obtains information that a sample container 30 is being fed from the first sample storage component 100 based on the trigger information fed back by the in-situ sensor.

[0086] In one implementation, the cap-opening component is used to open the sample container 30 located at the cap-opening position. The cap-opening position and the sample suction position 510 are located at the same location. After the first transfer component 109 transfers the sample container 30 to the sample suction position 510, the cap-opening component first opens the sample container 30 located at the sample suction position 510, and then the sample dispensing component 107 performs a sample suction operation on the sample container 30 located at the sample suction position 510 after the cap has been opened. In this implementation, setting the cap-opening position and the sample suction position 510 at the same location can improve the structural compactness of the sample analyzer 10 and reduce the number of working positions of the first transfer component 109. Of course, in specific applications, as an alternative implementation, the cap-opening position and the sample suction position 510 can also be located in two independent positions.

[0087] In one implementation, the controller 1001 is also configured to: after the sample dispensing component 107 draws at least a portion of the sample from the sample container 30 located at the aspiration position 510, control the cap opening component to perform a capping action on the sample container 30 located at the aspiration position 510. That is, after the aspiration is completed, the cap of the sample container 30 needs to be put back on the container body of the sample container 30, which helps to reduce the risk of biological contamination and disease transmission.

[0088] As one implementation of the sample container 30 from loading to sample aspiration completion, the controller 1001 is configured to: control the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 or the second sample storage component 200 to the identification position; control the identification component 108 to identify the sample container 30 located at the identification position to obtain at least the detection item information of the sample in the sample container 30; control the first transfer component 109 to transfer the sample container 30 that has been identified and whose detection item information has been obtained from the identification position to the buffer position 610; and control the first transfer component 109 to transfer the sample container 30 from the identification position to the buffer position 610. The container 30 is transferred from the buffer position 610 to the aspiration position 510. The opening component is controlled to open the sample container 30 located at the aspiration position 510. The sample dispensing component 107 is controlled to aspirate at least part of the sample from the sample container 30 located at the aspiration position 510 and whose cap has been opened, and to dispense all or part of the aspirated sample into the nucleic acid extraction container 40. The opening component is controlled to close the sample container 30 located at the aspiration position 510. The first transfer component 109 is controlled to transfer the closed sample container 30 from the aspiration position 510 to the second sample storage component 200 to await recycling.

[0089] Referring to Figures 10 and 6 and 11, in one embodiment, the second sample storage component 200 includes a second sample holder 210 and a second power component 220. The second sample holder 210 has at least one second receiving position 211. The second power component 220 is drively connected to the second sample holder 210 to drive the second sample holder 210 to move between a second open position and a second closed position. In this embodiment, the second sample storage component 200 is an electrically operated drawer-type structure. The second power component 220 can drive the second sample holder 210 to move between the second open position and the second closed position under the control of the controller 1001, thereby realizing the opening and closing of the second sample storage component 200 and improving the automation level of the sample analyzer 10. Of course, in specific applications, the arrangement of the second sample storage component 200 is not limited to this. For example, as an alternative embodiment, the second sample storage component 200 can also be configured as a manually operated drawer-type structure, or it can be configured as a drawer-type structure that can be electrically and manually controlled, or it can be configured as a structure that can be opened by flipping a lid or opening a door.

[0090] Referring to Figures 1, 2, and 7, in one embodiment, the sample analyzer 10 further includes a first consumable storage component 800, a second consumable storage component 900, a first reagent storage component 101, and a second reagent storage component 102. The first consumable storage component 800 is used to load the nucleic acid extraction container 40 to be used, and the nucleic acid extraction container 40 has a single nucleic acid extraction well 41 for holding a liquid prepared from at least the sample for nucleic acid extraction. The second consumable storage component 900 is used to load the amplification reaction container 50 to be used, and the amplification reaction container 50 has a single amplification reaction well 51 for holding a liquid containing at least the nucleic acid extraction solution for amplification detection. The first reagent storage component 101 is used to load extraction reagents. The second reagent storage component 102 is used to load amplification reaction reagents. The above-described control of the nucleic acid extraction component 300 to extract nucleic acid from the liquid prepared from at least the sample in the nucleic acid extraction container 40 includes: controlling the nucleic acid extraction component 300 to extract nucleic acid from the liquid prepared from at least the sample and extraction reagents in the nucleic acid extraction container 40. The aforementioned controlled amplification and detection component 400 performs amplification and detection on the liquid in the amplification reaction container 50, which contains at least nucleic acid extraction solution. This includes controlling the amplification and detection component 400 to perform amplification and detection on the liquid in the amplification reaction container 50, which contains at least nucleic acid extraction solution and amplification reaction reagents. The nucleic acid extraction container 40 can hold a single sample for nucleic acid extraction, and the amplification reaction container 50 can hold a nucleic acid extraction solution prepared from a single sample for amplification and detection. This facilitates rapid nucleic acid extraction and amplification detection for scattered and urgent samples, without worrying about wasting consumables.

[0091] Referring to Figure 14 and in conjunction with Figures 1 and 6, in one embodiment, the sample analyzer 10 further includes a display screen 700; the controller 1001 is further configured to control the display screen 700 to display a first interface 710, which displays the arrangement information of each first accommodating position 113 on the first sample storage component 100 and each second accommodating position 211 on the second sample storage component 200, loading information, and sample status information in each loaded sample container 30 (as shown in Figure 10). The arrangement information of each first accommodating position 113 and each second accommodating position 211 displayed on the first interface 710 characterizes the arrangement of each first accommodating position 113 on the first sample storage component 100 and each second accommodating position 211 on the second sample storage component 200. The loading information includes whether each first accommodating position 113 and each second accommodating position 211 is loaded with a sample container 30. The controller 1001 is also configured to: when it is determined that the sample container 30 has a first abnormal phenomenon, the control display screen 700 marks the sample container 30 on the first interface 710, that is, the sample container 30 is marked as abnormal on the first interface 710. In this way, the operator can intuitively see the location of the sample container 30 with the abnormal phenomenon.

[0092] As one implementation, the sample status information in each loaded sample container 30 includes: progress information and abnormal status information of each loaded sample container 30. The progress information includes, but is not limited to, pending identification, identification completed and pending sample aspiration, sample aspiration completed, and detection completed.

[0093] As one implementation method, the first interface 710 also displays sample details after identification is completed. The sample details include, but are not limited to, the sample category (including routine and emergency), number, test items, status (or progress, identification completed and sample aspiration is pending, sample aspiration completed, test completed), and completion time.

[0094] Referring to Figure 12 and in conjunction with Figures 1, 2, 6, 11, 13, and 14, in one embodiment, the controller 1001 is further configured to: control the display screen 700 to display the main interface 730, the main interface 730 displaying at least the loading information of the nucleic acid extraction container 40 on the first consumable storage component 800, the loading information of the amplification reaction container 50 on the second consumable storage component 900, the loading information of the extraction reagent on the first reagent storage component 101, the loading information of the amplification reaction reagent on the second reagent storage component 102, the loading information of the sample container 30 on the first sample storage component 100, and the loading information of the sample container 30 on the second sample storage component 200. The sample analyzer 10 also includes a first trigger control 103 and a second trigger control 104; the control display screen 700 displays a first interface 710, including: in response to the operator's operation of the first trigger control 103, controlling the first power component 120 to drive the first sample holder 110 to move from the first open position to the first closed position, and controlling the display screen 700 to switch from the main interface 730 to the first interface 710; or, in response to the operator's operation of the second trigger control 104, controlling the second power component 220 to drive the second sample holder 210 to move from the second open position to the second closed position, and controlling the display screen 700 to switch from the main interface 730 to the first interface 710. In this implementation scheme, the operator can activate the first trigger control 103 to trigger the first power component 120 to drive the first sample holder 110 from the first open position to the first closed position, and trigger the display screen 700 to automatically switch from the main interface 730 to the first interface 710. The operator can activate the second trigger control 104 to trigger the second power component 220 to drive the second sample holder 210 from the second open position to the second closed position, and trigger the display screen 700 to automatically switch from the main interface 730 to the first interface 710. This achieves the linkage between the sample feeding and the interface of the first sample storage component 100 and the second sample storage component 200, thereby facilitating the operator to better view the correlation information of each loaded sample.

[0095] In one implementation, the first trigger control 103 is a button, knob, or push button located on the body 105 above, below, or beside the first sample holder 110, and the second trigger control 104 is a button, knob, or push button located on the body 105 above, below, or beside the second sample holder 210. Of course, in specific applications, as an alternative implementation, the first trigger control 103 and the second trigger control 104 can also be virtual controls located on the interface of the display screen 700.

[0096] In one implementation, the controller 1001 is further configured to: when it is determined that the sample container 30 has a first abnormal phenomenon, control the display screen 700 to mark the sample container 30 on the main interface 730, that is, mark the sample container 30 as an abnormal state on the main interface 730.

[0097] In one implementation, the main interface 730 also displays the arrangement information and loading information of each first accommodating position 113 on the first sample storage component 100 and each second accommodating position 211 on the second sample storage component 200, as well as the sample status information in each loaded sample container 30. The sample status information in each loaded sample container 30 includes: progress information and abnormal status information of each loaded sample container 30. The progress information includes, but is not limited to, pending identification, identification completed and awaiting sample aspiration, sample aspiration completed, and detection completed.

[0098] Referring to Figure 15 and in conjunction with Figures 1, 6, 11, 13, and 14, in one embodiment, the controller 1001 is further configured to: in response to an operator's selection of a sample container 30 (i.e., a sample container 30 marked as abnormal) on the first interface 710 or the main interface 730, control the display screen 700 to display a second interface 720. The second interface 720 displays the cause of the abnormality of the sample container 30, and the first abnormal phenomenon includes at least the inability to obtain the detection item information of the sample in the sample container 30. In this embodiment, the operator can click on the abnormal sample on the display screen 700 to view the cause of the abnormality of the sample, thereby facilitating the operator to better handle the abnormal sample.

[0099] In one implementation, the controller 1001 is further configured to control the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 after sample aspiration to the carrying component 20 located in the second sample storage component 200, for awaiting recycling. In this embodiment, the sample container 30 fed from the first sample storage component 100 is transferred to the second sample storage component 200 after sample aspiration is completed, and placed there for awaiting recycling. This reduces the occupancy of the sample container 30 on the first sample storage component 100, allowing the first sample storage component 100 to meet the requirement of rapid sample loading. Furthermore, it facilitates the batch recycling of scattered samples, thereby reducing the number of recycling operations performed by operators and effectively minimizing the frequency of retrieval operations for scattered samples.

[0100] Referring to Figure 3 and in conjunction with Figures 1 and 10, in one embodiment, the supporting component 20 is a basket 22, and the second accommodating position 211 is also used to place the basket 22 in an empty state. The basket 22 can hold multiple sample racks 21, and each sample rack 21 can hold multiple sample containers 30. In daytime scenarios, regular samples are placed in the second sample storage component 200 in a basket 22 loading manner to achieve batch loading of regular samples into the sample analyzer 10, while emergency samples are placed in the first sample storage component 100 in a sample container 30 loading manner to achieve scattered and urgent sample loading into the sample analyzer 10. At least some container positions 23 in the basket 22 loaded from the second sample storage component 200 can be in an empty state to facilitate the retrieval of sample containers 30 loaded from the first sample storage component 100. In nighttime scenarios, samples are placed in the first sample storage component 100 in the form of sample containers 30 to enable sporadic loading of samples into the sample analyzer 10 at night. An empty basket 22 can be placed in the second sample storage component 200 to collect samples loaded from the first sample storage component 100 at night. Since the empty basket 22 can hold a large number of sample containers 30 to be collected, the basket 22 can be removed and the sample containers 30 can be collected only when it is full or at a preset time. This eliminates the need for operators to frequently collect sample containers 30 at night, thus reducing the workload of operators at night. Specifically, during the shift change between day and night, operators can place an empty carrying unit 20 (e.g., a basket 22 filled with empty sample racks 21) in advance in the second sample storage unit 200 for the purpose of collecting sample containers 30 after sampling at night. At night, when a sample needs to be tested for nucleic acid, operators can directly take the sample container 30 containing the sample to the sample analyzer 10 and place it in the first holding position 113 of the first sample storage unit 100. This eliminates the need for operators to find the sample rack 21 or open the sample container 30, greatly simplifying the operation steps, reducing the professional requirements for operators, and reducing the risk of infection for operators. Of course, in specific applications, the arrangement of the supporting component 20 is not limited to this. For example, as an alternative implementation, the supporting component 20 is a sample rack 21, and the second accommodating position 211 is also used for placing the sample rack 21 in an empty state; or, the supporting component 20 is a basket 22, and the basket 22 may not be loaded with the sample rack 21, but may directly load multiple sample containers 30 into the basket 22, and the second accommodating position 211 is also used for placing the sample rack 21 in an empty state.

[0101] In one implementation, the controller 1001 is further configured to control the first transfer component 109 to transfer the sample container 30, which has undergone sampling from the second sample storage component 200, to the carrier component 20 located in the second sample storage component 200, awaiting recycling. In this embodiment, samples fed from the second sample storage component 200 are recycled from the second sample storage component 200 after sampling, which helps reduce the frequency of sample recycling operations by operators.

[0102] In one implementation, the controller 1001 is further configured to: control the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 and exhibiting a second abnormality to the carrier component 20 located in the second sample storage component 200, pending retrieval processing. The controller 1001 is also configured to: control the first transfer component 109 to transfer the sample container 30 from the second sample storage component 200 and exhibiting a second abnormality to the carrier component 20 located in the second sample storage component 200, pending retrieval processing. The second abnormality in the sample container 30 includes: during the process of the sample dispensing component 107 aspirating at least a portion of the sample from the sample container 30 and dispensing all or part of the aspirated sample into the nucleic acid extraction container 40, determining that there is needle blockage, empty aspiration, or insufficient sample volume. Needle blockage may be caused by the presence of lint or clumping in the sample container 30. Empty aspiration may be caused by the presence of air bubbles in the sample. Insufficient sample volume may be caused by insufficient sampling volume or mixing of multiple samples. Since the sample container 30 exhibits a second anomaly, the operator cannot quickly handle the anomaly at the sample analyzer 10 to eliminate it. Therefore, the sample container 30 exhibiting the second anomaly is recovered through the second sample storage component 200 to avoid long-term occupation of the first sample storage component 100 by the sample container 30 exhibiting the second anomaly.

[0103] In one implementation, the controller 1001 is further configured to: before the amplification reaction and detection of the nucleic acid extract in the amplification reaction container 50 by the amplification detection component 400 are completed, if the sample corresponding to the nucleic acid extract is determined to be positive based on algorithm judgment and / or amplification curve characteristics, the control display screen 700 outputs a prompt message on the sample detection interface to indicate that the sample is positive.

[0104] Referring to FIG9, in one embodiment, the amplification detection component 400 includes a plurality of detection slots 413 and a plurality of temperature control devices. Each detection slot 413 is used to place an amplification reaction vessel 50, and each temperature control device is used to control the temperature of at least two detection slots 413.

[0105] As one implementation method, the temperature control device includes a Peltier, also known as a semiconductor refrigeration element, whose lifespan is affected by the number of thermal cycles.

[0106] In one implementation, the controller 1001 is further configured to: when it receives information that the amplification reaction container 50 has completed its entry into the amplification detection unit 400, and the amplification reaction container 50 is loaded with liquid containing at least a nucleic acid extract solution made from the first sample from the first sample storage unit 100, control the amplification detection unit 400 to begin amplification reaction and detection of the liquid containing at least the nucleic acid extract solution in the amplification reaction container 50. In this embodiment, after the sample fed from the first sample storage unit 100 has completed nucleic acid extraction and entered the amplification detection unit 400 through the amplification reaction container 50, amplification reaction and detection can begin, enabling on-demand testing of emergency samples and thus improving the testing efficiency of scattered and urgent samples.

[0107] Alternatively, as an alternative implementation, the controller 1001 is further configured to: when the amplification reaction container 50 enters the amplification detection unit 400 and the amplification reaction container 50 is loaded with a liquid containing nucleic acid extract made from a first sample from the first sample storage unit 100, and a first preset condition is met, control the amplification detection unit 400 to begin amplification reaction and detection of the liquid in the amplification reaction container 50 containing at least the nucleic acid extract. In this embodiment, after the sample fed from the first sample storage unit 100 completes nucleic acid extraction and enters the amplification detection unit 400 through the amplification reaction container 50, the amplification reaction and detection need to be started only after the first preset condition is met, in order to reduce the impact on the Peltier lifetime of the amplification detection unit 400.

[0108] In one implementation, the controller 1001 is further configured to: when the amplification reaction container 50 enters the amplification detection component 400, and the amplification reaction container 50 is loaded with liquid containing at least a nucleic acid extract prepared from the second sample from the second sample storage component 200, and a second preset condition is met, control the amplification detection component 400 to begin amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container 50. Meeting the second preset condition includes meeting at least one of the following conditions: the number of amplification reaction containers 50 in the amplification detection component 400 awaiting amplification detection and loaded with liquid containing at least a nucleic acid extract with amplification detection parameters identical to those of the nucleic acid extract prepared from the second sample reaches a target number; and the duration for which the amplification reaction container 50 enters the amplification detection component 400 reaches a second target duration. In this implementation, after the routine sample fed from the second sample storage component 200 completes nucleic acid extraction and enters the amplification detection component 400 through the amplification reaction container 50, a certain quantity or a certain duration is required before amplification reaction and detection begin, in order to reduce the impact on the Peltier lifetime of the amplification detection component 400.

[0109] In one implementation, satisfying the first preset condition includes at least satisfying the following condition: the time taken for the amplification reaction container 50, which contains at least a nucleic acid extract prepared from the first sample, to enter the amplification detection component 400 reaches a first target time. Wherein, the first target time is less than a second target time, and / or, the first target time is less than or equal to the time taken for the nucleic acid extraction component 300 to extract nucleic acid from the liquid prepared from at least the sample in a single nucleic acid extraction container 40. In this implementation, the waiting time after the nucleic acid extract prepared from the emergency sample loaded from the first sample storage component 100 enters the amplification detection component 400 through the amplification reaction container 50 is less than the waiting time after the nucleic acid extract prepared from the conventional sample loaded from the second sample storage component 200 enters the amplification detection component 400 through the amplification reaction container 50, thus facilitating the rapid detection needs of emergency samples.

[0110] In one implementation, the sample analyzer 10 is configured with a first detection mode and a second detection mode; the controller 1001 is further configured to: detect samples from the first sample storage component 100 in the first detection mode; and detect samples from the second sample storage component 200 in the second detection mode. In this implementation, two different detection modes are used for emergency samples and routine samples, which facilitates rapid detection of emergency samples.

[0111] In one implementation, the controller 1001 is further configured to: in response to an operator's selection of a detection mode on the display screen 700 interface, detect the sample in a first detection mode and in a second detection mode. In this embodiment, the operator selects whether to detect the sample in the first or second detection mode via the display screen 700 interface. Of course, in specific applications, as an alternative implementation, the controller 1001 may also automatically determine whether to select the first or second detection mode to detect the sample based on the sample loading position (whether it is loaded from the first sample storage component 100 or the second sample storage component 200) and / or based on the sample information identified and obtained by the identification component 108.

[0112] Referring to Figures 2, 6, and 9, in one embodiment, the sample analyzer 10 further includes a second transfer component 1002; the second transfer component 1002 is used to transfer an amplification reaction container 50 containing at least a nucleic acid extract to an amplification detection component 400. In the first detection mode, the controller 1001 is further configured to: control the second transfer component 1002 to transfer the amplification reaction container 50 containing at least a nucleic acid extract prepared from a sample from the first sample storage component 100 to the amplification detection component 400, and, in the event that a second preset condition is not met, control the amplification detection component 400 to begin amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container 50. In the second detection mode, the controller 1001 is further configured to: control the second transfer component 1002 to transfer the amplification reaction container 50, which contains at least a nucleic acid extract prepared from a sample from the second sample storage component 200, to the amplification detection component 400; and, when a second preset condition is met, control the amplification detection component 400 to begin amplification and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container 50. In this embodiment, after the nucleic acid extract prepared from a conventional sample (a sample fed from the second sample storage component 200) enters the amplification detection component 400, it needs to reach a certain quantity (i.e., the aforementioned target quantity) or a certain duration (i.e., the aforementioned second target duration) before amplification detection can begin, thereby ensuring the Peltier lifespan of the amplification detection component 400; while after the nucleic acid extract prepared from an emergency sample (a sample fed from the first sample storage component 100) enters the amplification detection component 400, it does not need to reach the target quantity or the second target duration required for conventional samples before amplification detection can begin, thereby facilitating rapid detection of emergency samples.

[0113] Referring to Figure 9 and in conjunction with Figures 2 and 6, in one embodiment, the amplification detection component 400 includes multiple independent amplification detection channels 410, each including at least one first-type detection channel 411 and at least one second-type detection channel 412. The controller 1001 is further configured to control the second transfer component 1002 to transfer an amplification reaction container 50 containing at least a nucleic acid extract prepared from a sample from the first sample storage component 100 to the first-type detection channel 411 for amplification reaction and detection. The controller 1001 is also configured to control the second transfer component 1002 to transfer the amplification reaction container 50 containing at least a nucleic acid extract prepared from a sample from the second sample storage component 200 to the second-type detection channel 412 for amplification reaction and detection. The first-type detection channel 411 is an emergency-specific amplification detection channel 410, and the second-type detection channel 412 is a conventional amplification detection channel 410. In this implementation, one or more detection amplification channels in the amplification detection component 400 are set as emergency-dedicated amplification detection channels 410. This ensures that emergency samples fed from the first sample storage component 100 can quickly enter the emergency-dedicated amplification detection channel 410 for amplification reaction and detection after nucleic acid extraction, without having to wait for the regular amplification detection channel 410 as with regular samples.

[0114] In one implementation, the controller 1001 is further configured to: detect samples from the first sample storage unit 100 in a first detection mode; and detect samples from the second sample storage unit 200 in a second detection mode. In the first detection mode, the controller 1001 is further configured to: control the second transfer component 1002 to transfer the amplification reaction container 50 containing at least a liquid containing nucleic acid extract made from a sample from the first sample storage component 100 to a first type detection channel 411, and, if the second preset condition is not met, control the amplification detection component 400 to start amplification reaction and detection of the liquid containing at least a nucleic acid extract in the amplification reaction container 50 in the first type detection channel 411; in the second detection mode, the controller 1001 is further configured to: control the second transfer component 1002 to transfer the amplification reaction container 50 containing at least a liquid containing nucleic acid extract made from a sample from the second sample storage component 200 to a second type detection channel 412, and, if the second preset condition is met, control the amplification detection component 400 to start amplification reaction and detection of the liquid containing at least a nucleic acid extract in the amplification reaction container 50 in the second type detection channel 412. In this implementation plan, two different detection modes and amplification detection channels 410 and amplification detection conditions are used for emergency samples and routine samples to ensure rapid detection of emergency samples.

[0115] In one implementation, each amplification detection channel 410 has multiple detection slots 413, each slot 413 for placing a single amplification reaction container 50. The controller 1001 is also configured to control the second transfer unit 1002 to transfer an amplification reaction container 50 containing at least a nucleic acid extraction solution at the same amplification detection temperature to the same amplification detection channel 410. In this embodiment, placing amplification reaction containers 50 for detection items at the same amplification detection temperature in the same amplification detection channel 410 for amplification reaction and detection facilitates the sharing of the same Peltier temperature control by multiple detection slots 413 in one amplification detection channel 410, thereby reducing the cost of the sample analyzer 10.

[0116] In one implementation, the target number is equal to the number of detection slots 413 included in a single amplification detection channel 410. Each temperature control device is used to control the temperature of each detection slot 413 in a single amplification detection channel 410.

[0117] In one implementation, the controller 1001 is further configured to: when the second transfer component 1002 completes the transfer of the amplification reaction container 50 containing at least a liquid containing nucleic acid extract made from a sample from the second sample storage component 200 to the last empty detection slot 413 of an amplification detection channel 410, the controller starts to control the amplification detection channel 410 to perform amplification reaction and detection on the liquid containing at least a nucleic acid extract in the amplification reaction container 50; and when the second transfer component 1002 completes the transfer of the amplification reaction container 50 containing at least a liquid containing nucleic acid extract made from a sample from the first sample storage component 100 to a detection slot 413 of an amplification detection channel 410, and the amplification detection channel 410 may have one or more detection slots 413 in an empty state, the controller starts to control the amplification detection channel 410 to perform amplification reaction and detection on the liquid containing at least a nucleic acid extract in the amplification reaction container 50. In this implementation scheme, after the nucleic acid extract prepared from a conventional sample (sample loaded from the second sample storage component 200) enters an amplification detection channel 410 through the amplification reaction container 50, amplification detection will only begin after all the detection slots 413 in the amplification detection channel 410 are filled with the amplification reaction container 50. This helps to ensure the Peltier lifespan of the amplification detection component 400. However, after the nucleic acid extract prepared from an emergency sample (sample loaded from the first sample storage component 100) enters another amplification detection channel 410 through the amplification reaction container 50, amplification detection will not begin after all the detection slots 413 in the amplification detection channel 410 are filled with the amplification reaction container 50. That is, amplification detection can begin even when there is at least one empty detection slot 413 in the amplification reaction channel, which facilitates the rapid detection of emergency samples.

[0118] Referring to FIG8, in one embodiment, the nucleic acid extraction component 300 is provided with a lysis zone 310, a washing zone 320, a drying zone 330 and an elution zone 340; the nucleic acid extraction component 300 also includes a third transfer component, which is used to sequentially transfer a nucleic acid extraction container 40 containing at least a liquid made from a sample to the lysis zone 310, the washing zone 320, the drying zone 330 and the elution zone 340.

[0119] Referring to FIG8, in one embodiment, the washing zone 320 includes a first sub-washing zone 321320 and a second sub-washing zone 322320; the second transfer component 1002 is used to sequentially transfer the nucleic acid extraction container 40, which is loaded with at least a liquid made from the sample, to the lysis zone 310, the first sub-washing zone 321320, the second sub-washing zone 322320, the drying zone 330 and the elution zone 340.

[0120] This application provides a sample loading and unloading process for the emergency testing channel (i.e., the first sample storage component 100) of a molecular diagnostic integrated machine, offering a simpler and safer method for sample loading and retrieval during nighttime emergencies, enabling rapid nucleic acid testing of emergency samples. Specifically, the emergency testing channel (i.e., the first sample storage component 100) is equipped with two loading ports (i.e., two first accommodating positions 113), allowing operators to directly place sample containers 30 into the loading ports to meet the need for rapid loading of sporadic samples during nighttime testing. Simultaneously, the sample analyzer 10 internally has three sets of buffer positions 610 for emergency sample buffering to queue for sample aspiration, thereby quickly releasing the first sample storage component 100 to meet the need for rapid and continuous loading of samples into the first sample storage component 100. In addition, the sample analyzer 10 is equipped with eight amplification detection channels 410, each of which can hold six samples. Each sample, in conjunction with a single-use extraction strip (i.e., the aforementioned nucleic acid extraction container 40) and a single-use PCR tube (i.e., the aforementioned amplification reaction container 50), completes the extraction of the sample and the construction of the PCR reaction system, which can meet the needs of rapid detection of emergency samples and achieve the effect of truly prioritizing the detection of emergency samples. Specifically, after the operator places the sample container 30 in the first accommodating position 113 and presses the emergency loading button (i.e., the aforementioned first trigger control 103), the sample is automatically loaded. Subsequently, the first transfer component 109 grabs the sample container 30, scans its barcode, and transfers it to the internal buffer position 610 for caching. The interface is simultaneously updated with the test information of the emergency sample and the estimated completion time. After the first transfer component 109 grabs the last sample on the first sample storage component 100 and scans its barcode, the first sample holder 110 of the first sample storage component 100 automatically pops out, and the operator can continue to load samples into the first sample holder 110. The first transfer unit 109 picks up the sample container 30 that is cached in the buffer position 610 and waiting for sampling, and moves it to the sampling position 510 to perform the opening, sampling, and closing operations in sequence. Then, it transfers the container to the second sample storage unit 200 for retrieval. The interface displays the position of the sample container 30 within the second sample storage unit 200 and the status of completed sampling. The second sample storage unit 200 serves as a unified retrieval area for emergency samples after sampling. Operators only need to load samples from the first sample storage unit 100 without any further operation. If the second sample storage unit 200 is full and the operator does not retrieve the samples in time, and samples arrive at night, the operator can still load several samples consecutively from the first sample storage unit 100. When the maximum sample loading capacity is reached, the first sample storage component 100 can no longer continuously load samples and the first sample storage component 100 is turned off. However, the emergency samples inside the sample analyzer 10 continue to undergo the normal sample aspiration and testing process. The sample containers 30 that have been aspirated are temporarily stored in the buffer position 610 or the first storage position 113. The corresponding interface prompts the operator to retrieve and clean the sample containers 30 of the second sample storage component 200.The operator opens the second sample storage component 200, removes the basket 22 and places a new empty basket 22 in its place. After closing the drawer, the first sample storage component 100 resumes normal operation. The operator can directly remove the sample container 30 from the basket 22 and transfer it to the freezer for storage. When an anomaly is detected in the sample container 30 of the first sample storage component 100, it is picked up by the first transfer component 109, placed in the first sample holder 110, and automatically ejected from the sample analyzer 10. The interface of the first sample storage component 100 will then display a corresponding indication that the sample is in an abnormal state, helping the operator to promptly identify and quickly handle the abnormal sample container 30.

[0121] The sample analyzer 10 provided in this application embodiment optimizes the sample detection process to meet the needs of rapid detection of emergency samples, outpatient samples, or nighttime samples. Specifically, this includes the following main aspects:

[0122] (1) The sample loading unit is equipped with two sample loading areas: a routine sample area (i.e., the second sample storage unit 200) and an emergency sample area (i.e., the first sample storage unit 100). In the routine sample area, operators can load samples using the basket 22 or the sample rack 21, loading multiple samples (more than ten) at a time to meet the application needs of batch loading of routine samples and loading samples during peak respiratory periods. In the emergency sample area, two loading ports (i.e., two first accommodating positions 113) are provided, allowing operators to load samples using sample containers 30 to meet the application needs of loading samples at night, in the emergency room, and in small quantities.

[0123] (2) In the amplification detection component 400, eight amplification detection channels 410 are set up. Each amplification detection channel 410 uses the same Peltier (i.e., temperature control device) to control the reaction temperature, which not only reduces costs but also supports the simultaneous detection of at least eight sample items. Furthermore, if any of the eight amplification detection channels 410 experiences temperature or signal acquisition abnormalities, the sample analyzer 10 can automatically shield the faulty channel to ensure normal sample detection. Each amplification detection channel 410 can accommodate six samples (six amplification reaction containers 50) for detection. Each sample is used with a single-use nucleic acid extraction strip (i.e., a nucleic acid extraction container 40 with a single extraction well) and a single-use PCR tube (i.e., an amplification reaction container 50 with a single amplification reaction well 51) to complete the nucleic acid extraction and PCR reaction system construction. This eliminates the need for operators to sort, collect, and perform other pretreatment processes according to the sample detection items. Compared with related technologies that use multi-well nucleic acid extraction plates and multi-well amplification detection plates, this avoids the waste of consumables.

[0124] (3) For nighttime samples, emergency samples, outpatient samples, or other sporadic samples, samples are loaded from the emergency sample area (i.e., the first sample storage component 100). Based on the department's emergency sample volume, operators can set one or more amplification detection channels 410 as dedicated emergency amplification detection channels 410. After the sample analyzer 10 detects a sample being loaded in the emergency sample area, it prioritizes the sample for aspiration, loading, and nucleic acid extraction. After completing the sample system construction, it transfers a single-use PCR tube (i.e., a single-well amplification reaction container 50) containing the nucleic acid extract prepared from the sample to the dedicated emergency amplification detection channel 410 to begin amplification reaction and detection, achieving the effect of prioritizing the detection of emergency samples. Furthermore, the sample analyzer 10 can automatically calculate the department's emergency sample volume and routine sample volume by year and quarter, and automatically reserve dedicated emergency amplification detection channels 410, more intelligently meeting the department's needs.

[0125] (4) In the case of multi-item mixed testing, after the operator loads samples in batches from the regular sample area (i.e., the second sample storage component 200), the controller 1001 automatically allocates the amplification detection channel 410 according to the same item amplification program. Compared with the case of single-person sample amplification detection, the amplification detection of the same sample detection items in this embodiment can be allocated to the same group of amplification detection channels 410 for amplification and detection, which improves the utilization rate of the amplification detection component 400, extends the life of Peltier, and achieves a more economical and simpler sample detection effect.

[0126] Prior to this application, the detection methods of molecular diagnostic integrated machines were mainly divided into two types: one method was batch sample loading, which involved batch amplification using 96- or 48-well amplification reaction plates. The amplification procedures for each sample's detection item differed, and one amplification reaction plate corresponded to only one sample detection item, failing to meet the needs of users who wanted to load multiple samples for mixed detection items. Before starting testing, users needed to sort samples by item and collect 96 or 48 samples before batch loading to avoid wasting amplification reaction plates. In batch amplification mode, there was no concept of emergency cases. Although there was an emergency sample rack 21, it only supported priority aspiration and separation, and all samples in the batch still needed to be amplified together, failing to achieve priority results for emergency samples. The other detection method was independent amplification detection for single-person samples, corresponding to scenarios where samples were tested as soon as they arrived. However, each amplification detection channel 410 required an independent Peltier tube to control the reaction temperature, increasing the cost of the sample analyzer 10. Meanwhile, the lifespan of the Peltier is limited by the number of amplification tests. With the same sample volume, the amplification test channel 410 for a single sample is used more times, resulting in a shorter Peltier lifespan and higher maintenance costs for the sample analyzer 10. Therefore, previous related technical approaches limited the processing method of the amplification test component 400, failing to meet the testing scenarios of batch sample testing and rapid emergency sample testing, and thus failing to satisfy the application requirements for economical and rapid results.

[0127] (5) Regarding the testing mode, an amplification testing process that combines emergency mode (i.e., the first testing mode) and routine batch testing mode (i.e., the second testing mode) is proposed, providing true emergency priority and helping users reduce costs and simplify workflows. Molecular diagnostic departments typically order about twenty types of sample testing items, but the sample volume for each item is relatively small. Most molecular testing items, such as hepatitis, tuberculosis, cytomegalovirus, and EB virus, do not have high requirements for report time. To reduce costs, departments conduct one to two tests per sample testing item per week. The amplification testing conditions required for each molecular testing item differ, such as reaction temperature, reaction time, and fluorescence channels. In related technologies prior to this application, one sample analyzer 10 was allocated to each sample testing item to meet the need for simultaneous testing of multiple sample testing items on the same day. For some special sample testing items, such as respiratory testing items, clinical requirements dictate that reports be issued within two hours, requiring immediate testing after sample collection. Respiratory samples mainly come from outpatients and emergency room patients. Sample collection time is not concentrated, with the morning being the busiest time and afternoon and night shifts seeing scattered samples. Therefore, the sample analyzer 10 needs to have both batch routine testing and scattered rapid testing modes to meet the sample flow characteristics and report generation time requirements. This implementation plan, by setting two testing modes, can well take into account the testing needs of the emergency mode (i.e., the first testing mode) and the routine batch testing mode (i.e., the second testing mode).

[0128] (6) Regarding quality control testing, since only two quality control samples (positive and negative) are tested daily, quality control testing is not performed on every amplification detection channel 410 every day. However, it is necessary to ensure that the detection quality of each amplification detection channel 410 can be guaranteed for a certain period of time. Therefore, in this embodiment, when carrying out daily quality control projects, the sample analyzer 10 will automatically accumulate the number of quality control tests for each group of amplification detection channels 410 and automatically allocate the amplification detection channels 410 for quality control based on the accumulated number of tests, so as to achieve quality testing for each group of amplification detection channels 410.

[0129] (7) Regarding the handling of abnormal samples, this implementation plan proposes a new emergency sample channel (i.e., the first sample storage component 100), which can both enable the loading of emergency samples onto the machine and reuse the emergency loading port (i.e., the first accommodating position 113) to achieve the automatic recovery of at least some abnormal samples.

[0130] Depending on the usage scenario, the sample loading area is divided into a regular sample drawer (i.e., the second sample storage component 200) and an emergency sample drawer (i.e., the first sample storage component 100). The regular sample drawer supports batch loading via baskets 22 or sample racks 21, with samples being aspirated and tested sequentially to meet the high-throughput batch sample loading requirements. The emergency sample drawer has two loading ports (i.e., two first accommodating positions 113), allowing operators to directly place sample containers 30 at these ports to meet the needs of rapid loading of sporadic samples at night and sample queue testing. After samples are loaded from the emergency sample drawer, the sample analyzer 10 prioritizes scanning samples loaded from the emergency sample drawer, and the completed sample containers 30 are transferred to the regular sample drawer for recycling. The regular sample drawer needs to reserve at least one empty sample rack 21 specifically for recycling completed emergency samples.

[0131] In order to avoid affecting the normal testing of samples in the regular sample drawer and to reduce the number of manual steps for operators to locate abnormal samples, this implementation plan automatically retrieves abnormal samples identified during sample testing from the emergency sample drawer.

[0132] Abnormal samples are categorized based on the operator's handling method and processing time. The first category of abnormal samples can be quickly processed by the operator next to the sample analyzer 10, such as barcode recognition anomalies, missing items, and LIS download anomalies. The second category requires processing by the operator inside a biosafety cabinet and takes longer, such as blocked needles (containing clots or lint), empty aspiration (containing air bubbles), and insufficient sample volume. The third category requires no processing by the user, such as abnormal sample quality (e.g., hemolysis, lipemia) and abnormal detection (e.g., abnormal extraction, abnormal amplification detection). During sample testing, if an abnormal sample is detected in the regular sample drawer or emergency sample drawer, the sample analyzer 10 first determines the type of abnormality.

[0133] For the first type of abnormal samples mentioned above, operators need to supplement the barcode or sample testing information, which can be quickly retrieved and processed through the first sample storage component 100. When supplementing the barcode information, operators need to refer to the sample container 30 or the testing application form to avoid errors that could prevent the results from being uploaded. When the first type of abnormal sample is identified, the interface indicates the location and cause of the abnormality, and provides a prompt in conjunction with the status light of the sample compartment drawer. The sample analyzer 10 automatically transfers the abnormal sample to the emergency loading port for retrieval. In the sample management interface, after quickly supplementing the barcode and / or item information of the sample container 30 by referring to the sample container 30, the abnormality prompt is automatically cleared. Operators can open the regular sample drawer and return it to its original position, or specify the loading location to quickly load the sample from the emergency sample drawer.

[0134] For the second type of abnormal samples mentioned above, they can be recycled and processed through the second sample storage component 200.

[0135] For the third type of abnormal samples mentioned above, the sample analyzer 10 performs the normal sampling and testing process. The samples can be retrieved and processed through the second sample storage component 200. After testing, the sample result is marked on the current results interface, indicating abnormal sample quality. Operators can use this marking to assist in analyzing and reviewing the results. These abnormal samples do not need to be retrieved and processed through the emergency testing channel.

[0136] A second aspect of this application provides a sample analyzer 10, which includes a first sample storage component 100, a second sample storage component 200, a first transfer component 109, a sample dispensing component 107, a nucleic acid extraction component 300, a pipetting component 106, an amplification and detection component 400, and a controller 1001. The first sample storage component 100 is used to place a sample container 30 containing samples for sample loading; the second sample storage component 200 is also used to place the sample container 30 containing samples for sample loading. Samples from the first sample storage component 100 have a higher detection priority than samples from the second sample storage component 200; that is, samples loaded later from the first sample storage component 100 can be sampled and detected before samples loaded earlier from the second sample storage component 200. The controller 1001 is configured to: control the sample dispensing unit 107 to aspirate at least a portion of the sample from the sample container 30 from the first sample storage unit 100 and dispense all or part of the aspirated sample into the nucleic acid extraction container 40; control the nucleic acid extraction unit 300 to extract nucleic acid from the liquid in the nucleic acid extraction container 40, which is at least made from the sample, to obtain a nucleic acid extract; control the pipetting unit 106 to transfer the nucleic acid extract in the nucleic acid extraction container 40 into the amplification reaction container 50; control the amplification detection unit 400 to perform amplification reaction and detection on the nucleic acid extract in the amplification reaction container 50; and output the detection result of the sample based on the detection information fed back by the amplification detection unit 400. The controller 1001 is further configured to: control the sample dispensing component 107 to aspirate at least a portion of the sample from the sample container 30 of the second sample storage component 200 and dispense all or part of the aspirated sample into the nucleic acid extraction container 40; control the nucleic acid extraction component 300 to extract nucleic acids from the liquid in the nucleic acid extraction container 40, which is at least made from the sample, to obtain a nucleic acid extract; control the pipetting component 106 to transfer the nucleic acid extract from the nucleic acid extraction container 40 into the amplification reaction container 50; control the amplification detection component 400 to perform amplification reaction and detection on the nucleic acid extract in the amplification reaction container 50; and output the detection result of the sample based on the detection information fed back by the amplification detection component 400. The controller 1001 is also configured to: control the first transfer component 109 to transfer the sample container 30 from the second sample storage component 200 that meets a first preset rule to the first sample storage component 100 for awaiting recycling; and control the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 that meets a second preset rule to the second sample storage component 200 for awaiting recycling.This implementation scheme sets up a first sample storage component 100 for emergency sample loading and a second sample storage component 200 for routine sample loading. It also controls the retrieval of sample containers 30 from the second sample storage component 200 that meet a first preset rule from the first sample storage component 100, and controls the retrieval of sample containers 30 from the first sample storage component 100 that meet a second preset rule from the second sample storage component 200. This achieves cross-retrieval of sample containers 30 from the second sample storage component 200 and sample containers 30 from the first sample storage component 100, thus facilitating the retrieval needs of different sample containers 30.

[0137] In one implementation, the first sample storage component 100 has a first accommodating position 113 for placing a single sample container 30 containing a sample to achieve sample loading; the second sample storage component 200 has a second accommodating position 211 for placing a carrier component 20 containing a sample container 30 and the sample container 30 containing a sample to achieve sample loading, and the carrier component 20 has multiple container positions 23, each container position 23 for placing a single sample container 30. The first sample storage component 100 can achieve rapid loading of scattered samples and emergency samples; the second sample storage component 200 can achieve batch loading of regular samples.

[0138] In one implementation, the first preset rule includes the presence of a first abnormality in sample container 30. In prior art, after determining that sample container 30 is abnormal, it is transferred to the regular loading channel (i.e., the second sample storage component 200) for recycling. When operators need to locate and handle the abnormal sample container 30, they must position it in the second sample storage component 200 according to the shelf number on the sample rack 21, find the corresponding abnormal sample container 30 on the sample rack 21, and then check the information of the sample container 30 on the interface to see the cause of the abnormality. This operation is very cumbersome and affects the normal testing of samples in the second sample storage component 200. In this implementation, some abnormal sample containers 30 can be recycled from the emergency loading channel (first sample storage component 100), meaning the first sample storage component 100, used for emergency sample loading, can be reused for recycling some abnormal sample containers 30, thereby reducing the number of manual steps required for users to locate these abnormal sample containers 30.

[0139] In one implementation, the controller 1001 is further configured to control the first transfer component 109 to transfer sample containers 30 from the first sample storage component 100 that meet the first preset rules to the first sample storage component 100 for recycling. In this implementation, regardless of whether the sample containers 30 are fed from the second sample storage component 200 or the first sample storage component 100, as long as the first abnormal phenomenon exists, they can be recycled from the first sample storage component 100 to meet the requirement of rapid recycling of some abnormal samples.

[0140] In one implementation, the sample analyzer 10 further includes an identification component 108; before the controller 1001 controls the sample dispensing component 107 to draw at least a portion of the sample from the sample container 30 of the first sample storage component 100, the controller 1001 is further configured to: control the identification component 108 to identify the sample container 30 from the first sample storage component 100 to obtain detection item information of the sample in the sample container 30; before the controller 1001 controls the sample dispensing component 107 to draw at least a portion of the sample from the sample container 30 of the second sample storage component 200, the controller 1001 is further configured to: control the identification component 108 to identify the sample container 30 from the second sample storage component 200 to obtain detection item information of the sample in the sample container 30. The aforementioned control sample allocation component 107 draws at least a portion of the sample from the sample container 30 of the first sample storage component 100, including: when the identification component 108 identifies the information fed back from the sample container 30 of the first sample storage component 100 and obtains the detection item information of the sample in the sample container 30, the control sample allocation component 107 draws at least a portion of the sample from the sample container 30 of the first sample storage component 100 and has been identified by the identification component 108. The aforementioned control sample allocation component 107 draws at least a portion of the sample from the sample container 30 of the second sample storage component 200, including: when the identification component 108 identifies the information fed back from the sample container 30 of the second sample storage component 200 and obtains the detection item information of the sample in the sample container 30, the control sample allocation component 107 draws at least a portion of the sample from the sample container 30 of the second sample storage component 200 and has been identified by the identification component 108. The first abnormal phenomenon includes at least: the inability to obtain the detection item information of the sample in the sample container 30, i.e., an identification abnormality. Since there are sample containers 30 with abnormal identification phenomena, the operator can quickly process them in the sample analyzer 10 to eliminate the abnormality. Therefore, in this embodiment, regardless of whether the sample container 30 is fed from the second sample storage component 200 or the first sample storage component 100, as long as there is a sample container 30 with abnormal identification phenomena, it is retrieved from the first sample storage component 100 so that the operator can quickly process the abnormal phenomena of these abnormal sample containers 30.

[0141] In one implementation, the second preset rule includes: the sample container 30 exhibits a second abnormality, or the sample container 30 has completed sample aspiration. The controller 1001 is further configured to: control the first transfer component 109 to transfer the sample container 30 from the second sample storage component 200 that meets the second preset rule to the second sample storage component 200 for awaiting retrieval; wherein, the second abnormality of the sample container 30 includes: during the process of the sample dispensing component 107 aspirating at least a portion of the sample from the sample container 30 and dispensing all or part of the aspirated sample into the nucleic acid extraction container 40, it is determined that there is needle blockage, empty aspiration, or insufficient sample volume. Since the operator cannot quickly eliminate the abnormality of the sample container 30 exhibiting the second abnormality at the sample analyzer 10, the sample container 30 exhibiting the second abnormality is retrieved through the second sample storage component 200, which helps to avoid the long-term occupation of the first sample storage component 100 by the sample container 30 exhibiting the second abnormality.

[0142] In one embodiment, the sample analyzer 10 also includes a body 105; an identification position is also formed within the sample analyzer 10. The control identification unit 108 identifies the sample container 30 from the first sample storage unit 100, including: controlling the first transfer unit 109 to transfer the sample container 30 from the first sample holder 110 located in the first closed position to the identification position, and controlling the identification unit 108 to identify the sample container 30 located at the identification position. The control identification unit 108 also identifies the sample container 30 from the second sample storage unit 200, including: controlling the first transfer unit 109 to transfer the sample container 30 from the second sample storage unit 200 to the identification position, and controlling the identification unit 108 to identify the sample container 30 located at the identification position.

[0143] In one embodiment, the first sample storage component 100 includes a first sample holder 110 and a first power component 120. The first sample holder 110 has at least one first receiving position 113. The first power component 120 is driven to the first sample holder 110 to drive the first sample holder 110 to move relative to the body 105 between a first open position and a first closed position. When the first sample holder 110 is in the first open position, the first receiving position 113 is located outside the body 105 for the operator to place and retrieve the sample container 30. When the first sample holder 110 is in the first closed position, the first receiving position 113 is located inside the body 105 for the first transfer component 109 to retrieve and place the sample container 30.

[0144] In one implementation, the above-mentioned control of the first transfer component 109 to transfer the sample container 30 from the first sample storage component 100 and satisfying the first preset rule to the first sample storage component 100 for waiting for recycling includes: if the detection item information of the sample in the sample container 30 from the first sample holder 110 at the first closed position cannot be obtained, then the first transfer component 109 is first controlled to put at least one sample container 30 back on the first sample holder 110 located at the first closed position, and then the first power component 120 is controlled to drive the first sample holder 110 from the first closed position to the first open position for waiting for the operator to recycle.

[0145] In one implementation, controlling the first transfer component 109 to transfer sample containers 30 from the second sample storage component 200 that meet the first preset rules to the first sample storage component 100 for retrieval processing includes: if the detection item information of at least one sample container 30 from the second sample storage component 200 cannot be obtained, then controlling the first transfer component 109 to transfer at least one sample container 30 to the first sample holder 110 located in the first closed position, and then controlling the first power component 120 to drive the first sample holder 110 to move from the first closed position to the first open position for retrieval processing by the operator.

[0146] In one implementation, after an operator places at least one sample container 30 on the first sample holder 110 located in the first open position each time, the controller 1001 is further configured to: control the first power unit 120 to drive the first sample holder 110 from the first open position to the first closed position; after the first transfer unit 109 removes all the sample containers 30 from the first sample holder 110 located in the first closed position, or after the identification unit 108 completes the identification of all the sample containers 30 from the first sample holder 110 located in the first closed position, control the first power unit 120 to drive the first sample holder 110 from the first closed position to the first open position.

[0147] In one implementation, the sample analyzer 10 further includes a display screen 700; a first sample storage component 100 has a first accommodating position 113 for placing a single sample container 30 loaded with a sample to achieve sample loading; a second sample storage component 200 has a second accommodating position 211 for placing a carrier component 20 loaded with a sample container 30 and the sample container 30 loading a sample to achieve sample loading, the carrier component 20 has a plurality of container positions 23, each container position 23 for placing a single sample container 30; the controller 1001 is further configured to control the display screen 700 to display a first interface 710, the first interface 710 displaying the first accommodating positions 113 on the first sample storage component 100 and the second accommodating positions 211 on the second sample storage component 200. The system includes layout information, loading information, and sample status information in each loaded sample container 30; the layout information of each first accommodating position 113 and each second accommodating position 211 displayed on the first interface 710 corresponds to the layout of each first accommodating position 113 on the first sample storage component 100 and each second accommodating position 211 on the second sample storage component 200; the loading information includes whether each first accommodating position 113 and each second accommodating position 211 is loaded with sample containers 30; the controller 1001 is also configured to: when it is determined that there is a first abnormal phenomenon in the sample container 30, control the display screen 700 to mark the sample container 30 on the first interface 710; in response to the operator's selection operation of the marked sample container 30 on the first interface 710, control the display screen 700 to display the second interface 720, and the second interface 720 displays the reason for the abnormality of the sample container 30.

[0148] Apart from the above, other parts and principles of the sample analyzer 10 provided in the second aspect of the embodiments of this application can be referred to the sample analyzer 10 provided in the first aspect of the embodiments of this application, and will not be described in detail here.

[0149] A third aspect of this application provides a control method for a sample analyzer 10. The control method includes: controlling a sample dispensing component 107 to aspirate at least a portion of a sample from a sample storage component 100 having a first accommodating position 113 for placing a single sample container 30 containing a sample, and dispensing all or part of the aspirated sample into a nucleic acid extraction container 40; controlling a nucleic acid extraction component 300 to extract nucleic acid from a liquid at least composed of the sample in the nucleic acid extraction container 40 to obtain a nucleic acid extract; controlling a pipetting component 106 to transfer the nucleic acid extract from the nucleic acid extraction container 40 into an amplification reaction container 50; controlling an amplification detection component 400 to perform amplification and detection on the nucleic acid extract in the amplification reaction container 50; and outputting the sample detection result based on the detection information fed back by the amplification detection component 400. The control method further includes: controlling the sample dispensing component 107 to aspirate at least a portion of a sample from a sample container 30 of a second sample storage component 200, which has a second accommodating position 211 for placing the carrier component 20 and the carrier component 20 has multiple container positions 23, each container position 23 for placing a single sample container 30, and dispensing all or part of the aspirated sample into a nucleic acid extraction container 40; controlling the nucleic acid extraction component 300 to extract nucleic acid from the liquid at least made from the sample in the nucleic acid extraction container 40 to obtain a nucleic acid extract; controlling the pipetting component 106 to transfer the nucleic acid extract in the nucleic acid extraction container 40 into an amplification reaction container 50; controlling the amplification detection component 400 to perform amplification reaction and detection on the nucleic acid extract in the amplification reaction container 50; and outputting the detection result of the sample based on the detection information fed back by the amplification detection component 400.

[0150] In one implementation, before the control sample dispensing unit 107 draws at least a portion of a sample from a sample container 30 of a first sample storage unit 100 having a first accommodating position 113 for placing a single sample container 30 containing a sample, the control method further includes: controlling the identification unit 108 to identify the sample container 30 from the first sample storage unit 100 to obtain detection item information of the sample in the sample container 30. Before the control sample dispensing unit 107 draws at least a portion of a sample from a sample container 30 of a second sample storage unit 200 having a second accommodating position 211 for placing a carrier member 20, and the carrier member 20 having a plurality of container positions 23, each container position 23 for placing a single sample container 30, the control method further includes: controlling the identification unit 108 to identify the sample container 30 from the second sample storage unit 200 to obtain detection item information of the sample in the sample container 30.

[0151] In one embodiment, after an operator places at least one sample container 30 onto the first sample holder 110 of the first sample storage component 100, which is in the first open position, the control method further includes: controlling the first power component 120 of the first sample storage component 100 to drive the first sample holder 110 from the first open position to the first closed position; after the first transfer component 109 removes all the sample containers 30 from the first sample holder 110 in the first closed position, or after the identification component 108 completes the identification of all the sample containers 30 from the first sample holder 110 in the first closed position, controlling the first power component 120 to drive the first sample holder 110 from the first closed position to the first open position.

[0152] As one implementation, the above control method further includes: if it is impossible to obtain the detection item information of at least one sample from the sample container 30 on the first sample holder 110 at the first closed position, then first control the first transfer component 109 to put at least one sample container 30 back on the first sample holder 110 at the first closed position, and then control the first power component 120 to drive the first sample holder 110 from the first closed position to the first open position, so as to wait for the operator to retrieve and process it.

[0153] As one implementation, the above control method further includes: if the detection item information of at least one sample from the sample container 30 of the second sample storage component 200 cannot be obtained, then the first transfer component 109 is controlled to put at least one sample container 30 back into the second sample storage component 200 to wait for the operator to retrieve and process it, or the first transfer component 109 is first controlled to transfer at least one sample container 30 to the first sample holder 110 located in the first closed position, and then the first power component 120 is controlled to drive the first sample holder 110 from the first closed position to the first open position to wait for the operator to retrieve and process it.

[0154] Apart from the above, the specific principles and other parts of the control method of the sample analyzer 10 provided in the third aspect of the present application are similar to the control principle and implementation of the controller 1001 described in the sample analyzer 10 above, and will not be described in detail here.

[0155] A fourth aspect of this application provides a computer-readable storage medium storing a computer program. When the computer program is executed by a processor (e.g., the controller 1001 described above), it causes the processor to implement the steps of the control method for the sample analyzer 10 described above. The computer-readable storage medium can be an internal storage unit of the sample analyzer 10, such as a hard disk or memory of the sample analyzer 10; or it can be an external storage device of the sample analyzer 10, such as a pluggable hard disk, smart media card (SMC), secure digital (SD) card, flash card, etc., equipped on the sample analyzer 10.

[0156] The above description is merely a preferred embodiment of this application and does not limit the patent scope of this application. Any equivalent structural transformations made based on the inventive concept of this application and the contents of the specification and drawings of this application, or direct / indirect applications in other related technical fields, are included within the patent protection scope of this application.

Claims

1. A sample analyzer, characterized in that: It includes a first sample storage unit, a second sample storage unit, a sample dispensing unit, a nucleic acid extraction unit, a pipetting unit, an amplification and detection unit, and a controller, wherein: The first sample storage component has a first accommodating position, which is used to place a single sample container loaded with a sample to realize the feeding of the sample; The second sample storage component has a second accommodating position, which is used to place a carrier component loaded with a sample container and the sample container loaded with a sample to realize the feeding of the sample. The carrier component has multiple container positions, each of which is used to place a single sample container. The controller is configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample, which is located in the first sample storage component, and to dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the liquid in the amplification reaction container, which contains at least the nucleic acid extract; and output the detection result of the sample based on the detection information fed back by the amplification detection component. The controller is further configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample and originating from the second sample storage component, and to dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acid from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the liquid in the amplification reaction container, which contains at least the nucleic acid extract; and output the detection result of the sample based on the detection information fed back by the amplification detection component.

2. The sample analyzer as described in claim 1, characterized in that: The sample analyzer also includes a sample suction holder and a first transfer component, wherein the sample suction holder has a sample suction position; Before the controller controls the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample from the first sample storage component, the controller is further configured to: control the first transfer component to transfer the sample container containing the sample from the first sample storage component to the aspiration position; and / or, Before the controller controls the sample dispensing component to aspirate at least a portion of the sample from the sample container containing the sample from the second sample storage component, the controller is further configured to control the first transfer component to transfer the sample container containing the sample from the second sample storage component to the aspiration position.

3. The sample analyzer as described in claim 2, characterized in that: The sample analyzer also includes a buffer socket, which has buffer bits. The controller controls the first transfer component to transfer the sample container, which comes from the first sample storage component and contains the sample, to the sampling position, including: the controller controls the first transfer component to first transfer the sample container from the first sample storage component to the buffer position for caching, and then transfer the sample container from the buffer position to the sampling position.

4. The sample analyzer as described in claim 3, characterized in that: The first sample storage component has at least two first accommodating positions, each of which is used to place a single sample container loaded with a sample. The cache holder has at least two cache bits, each cache bit being used to place a single sample container to achieve caching of the sample container, and the number of cache bits is greater than or equal to the number of the first accommodating bits; The controller controls the first transfer component to transfer the sample container, which comes from the first sample storage component and contains the sample, to the sampling position, including: the controller controls the first transfer component to first transfer all the sample containers located in the first sample storage component to the buffer position for buffering, and then transfer the sample containers one by one from the buffer position to the sampling position.

5. The sample analyzer as described in claim 2, characterized in that: The sample analyzer also includes an identification component, and an identification position is formed within the sample analyzer; Before the controller controls the first transfer component to transfer the sample container, which comes from the first sample storage component and contains the sample, to the sampling position, the controller is further configured to: control the first transfer component to transfer the sample container from the first sample storage component to the identification position, and control the identification component to identify the sample container located at the identification position to obtain the detection item information of the sample in the sample container; Before the controller controls the first transfer component to transfer the sample container, which comes from the second sample storage component and contains the sample, to the sampling position, the controller is further configured to: control the first transfer component to transfer the sample container from the second sample storage component to the identification position, and control the identification component to identify the sample container located at the identification position to obtain the detection item information of the sample in the sample container.

6. The sample analyzer as described in claim 5, characterized in that: The sample analyzer also includes a buffer socket, which has buffer bits. After the controller controls the identification component to identify the sample container located at the identification position and obtains the detection item information of the sample in the sample container, the controller is further configured to: When the sampling position is vacant, the first transfer component is controlled to transfer the sample container located at the identification position to the sampling position. When the sampling position is occupied, the first transfer component is controlled to first transfer the sample container located at the identification position to the buffer position for caching. After the sampling position becomes vacant, the sample container is then transferred from the buffer position to the sampling position. Alternatively, the first transfer component can be controlled to transfer the sample container located at the identification position to the cache position for caching.

7. The sample analyzer as described in claim 5, characterized in that: The sample analyzer also includes a body, and the first sample storage component includes a first sample holder and a first power component. The first sample holder has at least one first receiving position, and the first power component is driven to the first sample holder to drive the first sample holder to move relative to the body between a first open position and a first closed position. When the first sample holder is in the first open position, the first receiving position is located outside the machine body, so that the operator can place and take the sample container; When the first sample holder is in the first closed position, the first receiving position is located inside the machine body, so that the first transfer component can pick up and place the sample container.

8. The sample analyzer as described in claim 7, characterized in that: After an operator places at least one of the sample containers onto the first sample holder located in the first open position each time, the controller is further configured to: control the first power unit to drive the first sample holder from the first open position to the first closed position; and control the first power unit to drive the first sample holder from the first closed position to the first open position after the first transfer unit has removed all the sample containers from the first sample holder located in the first closed position, or after the identification unit has completed identification of all the sample containers from the first sample holder located in the first closed position.

9. The sample analyzer as described in claim 7, characterized in that: The controller is also configured to: if it is impossible to obtain the detection item information of the sample in the sample container on the first sample holder at the first closed position, first control the first transfer component to put the at least one sample container back on the first sample holder located at the first closed position, and then control the first power component to drive the first sample holder from the first closed position to the first open position, so as to wait for the operator to retrieve and process it. Alternatively, the controller is further configured to: if it is impossible to obtain detection item information of at least one sample from the sample container of the second sample storage component, control the first transfer component to return the at least one sample container to the second sample storage component to await the operator's retrieval and processing; or first control the first transfer component to transfer the at least one sample container to the first sample holder located in the first closed position, and then control the first power component to drive the first sample holder from the first closed position to the first open position to await the operator's retrieval and processing.

10. The sample analyzer according to any one of claims 5 to 9, characterized in that: The sample analyzer also includes a cover-opening component; After the controller controls the identification component to identify the sample container located at the identification position and obtains the detection item information of the sample in the sample container, and before controlling the sample dispensing component to draw at least part of the sample from the sample container, the controller is further configured to: control the opening component to perform an opening action on the sample container; When an operator places the sample container in the first sample storage component, the controller is further configured to: control the identification component to pause identification of sample containers from the second sample storage component that have not yet begun identification, and control the capping component to pause the capping action of sample containers from the second sample storage component that have not yet begun the capping action, so as to first control the identification component to identify the sample container placed by the operator in the first sample storage component, control the capping component to perform the capping action of the sample container placed by the operator in the first sample storage component, and control the sample dispensing component to aspirate at least a portion of the sample from the sample container placed by the operator in the first sample storage component and located at the aspiration position, and to dispense all or part of the aspirated sample into the nucleic acid extraction container.

11. The sample analyzer according to any one of claims 1 to 9, characterized in that: The sample analyzer also includes a body, and the first sample storage component includes a first sample holder and a first power component. The first sample holder has at least one first receiving position, and the first power component is driven to the first sample holder to drive the first sample holder to move relative to the body between a first open position and a first closed position. When the first sample holder is in the first open position, the first receiving position is located outside the machine body, so that the operator can place and take the sample container; When the first sample holder is in the first closed position, the first receiving position is located inside the machine body, so that the first transfer component can pick up and place the sample container; The body includes a face shell, and the face shell has a first opening; The first sample holder includes a seat body and a first baffle, and the first sample storage component further includes a second baffle; the seat body forms at least one first receiving position; the first baffle can switch between a first state and a second state under the drive of the first power component, in the first state, the first baffle closes the first opening, and in the second state, the first baffle avoids the first opening; The second baffle can switch between a third state and a fourth state under the drive of the first power component. In the third state, the second baffle avoids the first opening, and in the fourth state, the second baffle closes the first opening. When the first sample holder is in the first open position, the first baffle is in the first state, and the second baffle is in the third state; When the first sample holder is in the first closed position, the first baffle is in the second state, and the second baffle is in the fourth state.

12. The sample analyzer according to any one of claims 1 to 9, characterized in that: The sample analyzer also includes a display screen; The controller is further configured to: control the display screen to display a first interface, the first interface displaying the arrangement information and loading information of each first accommodating position on the first sample storage component and each second accommodating position on the second sample storage component, as well as the sample status information in each loaded sample container; The arrangement information of each first accommodating position and each second accommodating position displayed on the first interface represents the arrangement of each first accommodating position on the first sample storage component and each second accommodating position on the second sample storage component. The loading information includes whether each of the first and second accommodating positions is loaded with the sample container; The controller is also configured to: when it is determined that the sample container has a first abnormal phenomenon, control the display screen to identify the sample container on the first interface; In response to the operator's selection of the sample container marked on the first interface, the display screen is controlled to display a second interface, which displays the reason for the abnormality of the sample container. The first abnormality includes at least the inability to obtain the detection item information of the sample in the sample container. Preferably, the sample analyzer further includes a first consumable storage component, a second consumable storage component, a first reagent storage component, and a second reagent storage component. The first consumable storage component is used to load the nucleic acid extraction container to be used. The nucleic acid extraction container has a single nucleic acid extraction well for holding the liquid made from at least the sample for nucleic acid extraction. The second consumable storage component is used to load the amplification reaction container to be used, the amplification reaction container having a single amplification reaction well for carrying the liquid containing at least the nucleic acid extract for amplification detection; the first reagent storage component is used to load the extraction reagent; the second reagent storage component is used to load the amplification reaction reagent; The first sample storage component includes a first sample holder and a first power component. The first sample holder has at least one first receiving position. The first power component is driven to the first sample holder to drive the first sample holder to move between a first open position and a first closed position. The second sample storage component includes a second sample holder and a second power component. The second sample holder has at least one second receiving position. The second power component is drivenly connected to the second sample holder to drive the second sample holder to move between a second open position and a second closed position. The controller is further configured to: control the display screen to display a main interface, the main interface displaying at least the loading information of the nucleic acid extraction container on the first consumable storage component, the loading information of the amplification reaction container on the second consumable storage component, the loading information of the extraction reagent on the first reagent storage component, the loading information of the amplification reaction reagent on the second reagent storage component, the loading information of the sample container on the first sample storage component, and the loading information of the sample container on the second sample storage component; The sample analyzer also includes a first trigger control and a second trigger control; The control of the display screen to display the first interface includes: responding to the operator's operation on the first trigger control, controlling the first power component to drive the first sample holder to move from the first open position to the first closed position, and controlling the display screen to switch from the main interface to the first interface; or, responding to the operator's operation on the second trigger control, controlling the second power component to drive the second sample holder to move from the second open position to the second closed position, and controlling the display screen to switch from the main interface to the first interface.

13. The sample analyzer according to any one of claims 1 to 9, characterized in that: The controller is further configured to: control the first transfer component to transfer the sample container, which has been aspirated from the first sample storage component, to the carrier component located in the second sample storage component, for awaiting recycling processing; Preferably, the supporting component is a basket or a sample rack, and the second accommodating position is also used to place the basket or the sample rack in an unloaded state.

14. The sample analyzer as described in claim 1, characterized in that: The controller is further configured to: when it receives information that the amplification reaction container has completed the action of entering the amplification detection component, and the amplification reaction container is loaded with liquid containing at least the nucleic acid extract made from the first sample from the first sample storage component, or when the amplification reaction container enters the amplification detection component and the amplification reaction container is loaded with liquid containing the nucleic acid extract made from the first sample from the first sample storage component, and a first preset condition is met, control the amplification detection component to start amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container; The controller is further configured to: when the amplification reaction container enters the amplification detection component, and the amplification reaction container is loaded with a liquid containing at least the nucleic acid extract made from a second sample from the second sample storage component, and a second preset condition is met, control the amplification detection component to start amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container; Among them, satisfying the first preset condition includes at least satisfying the following condition: the amplification reaction container loaded with at least a liquid containing the nucleic acid extract made from the first sample enters the amplification detection component for a first target duration; Meeting the second preset condition includes meeting at least one of the following conditions: the number of amplification reaction containers in the amplification detection component that are waiting for amplification detection and are loaded with liquid containing at least the same amplification detection parameters as those of the nucleic acid extract prepared from the second sample reaches the target number; and the time for the amplification reaction container to enter the amplification detection component reaches the second target time. The first target duration is less than the second target duration, and / or the first target duration is less than or equal to the duration for which the nucleic acid extraction component extracts nucleic acid from the liquid at least made from the sample in a single nucleic acid extraction container; Alternatively, the amplification detection component includes multiple independent amplification detection channels, each amplification detection channel forming multiple detection slots, and each detection slot being used to place a single amplification reaction container; The sample analyzer also includes a second transfer component; The controller is also configured to control the second transfer component to transfer the amplification reaction vessel containing at least a liquid containing the nucleic acid extract at the same amplification detection temperature to the same amplification detection channel; When the second transfer component completes the transfer of the amplification reaction container containing at least a liquid made from the nucleic acid extract from the sample from the second sample storage component to the last empty detection slot of the amplification detection channel, the amplification detection channel is controlled to perform amplification reaction and detection on the liquid containing at least the nucleic acid extract in the amplification reaction container within it; When the second transfer component completes the transfer of the amplification reaction container containing at least a liquid made from the nucleic acid extract from the sample from the first sample storage component to a detection slot of an amplification detection channel, and the amplification detection channel may have one or more detection slots in an empty state, the amplification detection channel begins to control the amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container within it.

15. The sample analyzer as described in claim 14, characterized in that: The amplification detection component includes multiple independent amplification detection channels, and the multiple amplification detection channels include at least one type-1 detection channel and at least one type-2 detection channel; The sample analyzer is equipped with a first detection mode and a second detection mode; The sample analyzer also includes a second transfer component; The controller is further configured to: detect the sample from the first sample storage component in the first detection mode; and detect the sample from the second sample storage component in the second detection mode; In the first detection mode, the controller is further configured to: control the second transfer component to transfer the amplification reaction container containing at least a liquid made from the nucleic acid extract from the sample from the first sample storage component to a first type of detection channel, and, if the second preset condition is not met, control the amplification detection component to start amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container in the first type of detection channel; In the second detection mode, the controller is further configured to: control the second transfer component to transfer the amplification reaction container containing at least a liquid made from the nucleic acid extract from the sample from the second sample storage component to a second type of detection channel, and, when the second preset condition is met, control the amplification detection component to start amplification reaction and detection of the liquid containing at least the nucleic acid extract in the amplification reaction container in the second type of detection channel.

16. The sample analyzer as described in any one of claims 1 to 9, or 14 or 15, characterized in that: The detection priority of the sample from the first sample storage component is higher than the detection priority of the sample from the second sample storage component.

17. A sample analyzer, characterized in that: It includes a first sample storage component, a second sample storage component, a first transfer component, a sample dispensing component, a nucleic acid extraction component, a pipetting component, an amplification and detection component, and a controller, wherein: The first sample storage component is used to place a sample container containing the sample to achieve sample loading; The second sample storage component is used to place a sample container containing a sample to load the sample; the detection priority of the sample from the first sample storage component is higher than the detection priority of the sample from the second sample storage component; The controller is configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container originating from the first sample storage component and dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least composed of the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and output the detection result of the sample based on the detection information fed back by the amplification detection component. The controller is further configured to: control the sample dispensing component to aspirate at least a portion of the sample from the sample container of the second sample storage component and dispense all or part of the aspirated sample into a nucleic acid extraction container; control the nucleic acid extraction component to extract nucleic acids from the liquid in the nucleic acid extraction container, which is at least made from the sample, to obtain a nucleic acid extract; control the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; control the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and output the detection result of the sample based on the detection information fed back by the amplification detection component. The controller is further configured to: control the first transfer component to transfer the sample container from the second sample storage component and satisfying a first preset rule to the first sample storage component for recycling; and control the first transfer component to transfer the sample container from the first sample storage component and satisfying a second preset rule to the second sample storage component for recycling.

18. The sample analyzer as described in claim 17, characterized in that: The controller is further configured to: control the first transfer component to transfer the sample container from the first sample storage component and satisfying the first preset rule to the first sample storage component, so as to wait for recycling processing; The first preset rule includes the existence of a first anomaly in the sample container; Preferably, the sample analyzer further includes an identification component; Before the controller controls the sample dispensing component to draw at least a portion of the sample from the sample container from the first sample storage component, the controller is further configured to: control the identification component to identify the sample container from the first sample storage component to obtain detection item information of the sample in the sample container; Before the controller controls the sample dispensing component to draw at least a portion of the sample from the sample container from the second sample storage component, the controller is further configured to: control the identification component to identify the sample container from the second sample storage component to obtain detection item information of the sample in the sample container; The step of controlling the sample dispensing component to draw at least a portion of the sample from the sample container from the first sample storage component includes: when the detection item information of the sample in the sample container is obtained based on the information fed back by the identification component from the sample container from the first sample storage component, the step of controlling the sample dispensing component to draw at least a portion of the sample from the sample container from the first sample storage component and identified by the identification component. The step of controlling the sample dispensing component to draw at least a portion of the sample from the sample container from the second sample storage component includes: when the detection item information of the sample in the sample container is obtained based on the information fed back by the identification component from the sample container from the second sample storage component, the step of controlling the sample dispensing component to draw at least a portion of the sample from the sample container from the second sample storage component and identified by the identification component. The first abnormal phenomenon includes at least the inability to obtain the detection item information of the sample in the sample container.

19. The sample analyzer as described in claim 17 or 18, characterized in that: The second preset rule includes: the sample container exhibits a second abnormal phenomenon, or the sample container has completed aspiration; The controller is further configured to: control the first transfer component to transfer the sample container from the second sample storage component and satisfying the second preset rule to the second sample storage component for recycling processing; The second abnormal phenomenon of the sample container includes: during the process of the sample dispensing component drawing at least part of the sample from the sample container and dispensing all or part of the drawn sample into the nucleic acid extraction container, it is determined that there is a needle blockage, an empty aspiration, or an insufficient sample volume.

20. The sample analyzer as described in claim 17 or 18, characterized in that: The sample analyzer also includes a display screen; The first sample storage component has a first accommodating position, which is used to place a single sample container loaded with a sample to realize the feeding of the sample; The second sample storage component has a second accommodating position, which is used to place a carrier component loaded with a sample container and the sample container loaded with a sample to realize the feeding of the sample. The carrier component has multiple container positions, each of which is used to place a single sample container. The controller is further configured to: control the display screen to display a first interface, the first interface displaying the arrangement information and loading information of each first accommodating position on the first sample storage component and each second accommodating position on the second sample storage component, as well as the sample status information in each loaded sample container; The arrangement information of each first accommodating position and each second accommodating position displayed on the first interface corresponds to the arrangement of each first accommodating position on the first sample storage component and each second accommodating position on the second sample storage component; The loading information includes whether each of the first and second accommodating positions is loaded with the sample container; The controller is further configured to: when it is determined that the sample container has the first abnormal phenomenon, control the display screen to identify the sample container on the first interface; In response to the operator's selection of the sample container marked on the first interface, the display screen is controlled to display a second interface, which displays the cause of the abnormality of the sample container. Preferably, the sample analyzer further includes a first consumable storage component, a second consumable storage component, a first reagent storage component, and a second reagent storage component. The first consumable storage component is used to load the nucleic acid extraction container to be used. The nucleic acid extraction container has a single nucleic acid extraction well for holding the liquid made from at least the sample for nucleic acid extraction. The second consumable storage component is used to load the amplification reaction container to be used, the amplification reaction container having a single amplification reaction well for carrying the liquid containing at least the nucleic acid extract for amplification detection; the first reagent storage component is used to load the extraction reagent; the second reagent storage component is used to load the amplification reaction reagent; The first sample storage component includes a first sample holder and a first power component. The first sample holder has at least one first receiving position. The first power component is driven to the first sample holder to drive the first sample holder to move between a first open position and a first closed position. The second sample storage component includes a second sample holder and a second power component. The second sample holder has at least one second receiving position. The second power component is drivenly connected to the second sample holder to drive the second sample holder to move between a second open position and a second closed position. The controller is further configured to: control the display screen to display a main interface, the main interface displaying at least the loading information of the nucleic acid extraction container on the first consumable storage component, the loading information of the amplification reaction container on the second consumable storage component, the loading information of the extraction reagent on the first reagent storage component, the loading information of the amplification reaction reagent on the second reagent storage component, the loading information of the sample container on the first sample storage component, and the loading information of the sample container on the second sample storage component; The sample analyzer also includes a first trigger control and a second trigger control; The control of the display screen to display the first interface includes: responding to the operator's operation on the first trigger control, controlling the first power component to drive the first sample holder to move from the first open position to the first closed position, and controlling the display screen to switch from the main interface to the first interface; or, responding to the operator's operation on the second trigger control, controlling the second power component to drive the second sample holder to move from the second open position to the second closed position, and controlling the display screen to switch from the main interface to the first interface.

21. The sample analyzer as described in claim 17 or 18, characterized in that: The first sample storage component has a first accommodating position, which is used to place a single sample container loaded with the sample to realize the feeding of the sample; The second sample storage component has a second accommodating position for placing a carrier component that holds the sample container and the sample container holds the sample to realize the feeding of the sample. The carrier component has multiple container positions, each of which is used to place a single sample container.

22. A control method for a sample analyzer, characterized in that: include: The system controls a sample dispensing component to aspirate at least a portion of the sample from a sample storage component having a first accommodating position for placing a single sample container containing the sample, and to dispense all or part of the aspirated sample into a nucleic acid extraction container; controls a nucleic acid extraction component to extract nucleic acids from a liquid in the nucleic acid extraction container, which is at least made from the sample, to obtain a nucleic acid extract; controls a pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container into an amplification reaction container; and controls an amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container. Based on the detection information fed back by the amplification detection component, the detection result of the sample is output; The control method further includes: controlling the sample dispensing component to aspirate at least a portion of the sample from a sample container of a second sample storage component having a second accommodating position for placing a carrier component and the carrier component having multiple container positions, each container position for placing a single sample container, and dispensing all or part of the aspirated sample into a nucleic acid extraction container; controlling the nucleic acid extraction component to extract nucleic acid from a liquid in the nucleic acid extraction container made from at least the sample to obtain a nucleic acid extract; controlling the pipetting component to transfer the nucleic acid extract from the nucleic acid extraction container to an amplification reaction container; controlling the amplification detection component to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction container; and outputting the detection result of the sample based on the detection information fed back by the amplification detection component.

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