Applicator system for targeted application of a physiologically acceptable tooth whitening preparation

Abstract

The present invention relates to an applicator system (1) for a targeted application of a physiologically acceptable tooth whitening preparation. The applicator system comprises a first compartment (2) which contains an organic tooth whitening agent. It further comprises a second compartment (3) which contains an alkaline activation component. The applicator system comprises a separating structure (4), which separates the first compartment and the second compartment from one another in a fluid-tight manner in a first state and can be transferred into a second state such that the organic tooth whitening agent and the alkaline activation component can be mixed. The invention also relates to a corresponding method for using a corresponding applicator.

Description

[0001] Applicator system for targeted application of a physiologically compatible tooth whitening preparation.

[0002] The present invention relates to an applicator system for the targeted application of a physiologically compatible tooth whitening preparation, in particular for the targeted application of a physiologically compatible tooth whitening preparation in self-treatment, according to the preambles of the independent claims.

[0003] Technological background

[0004] For a long time, hydrogen peroxide-based teeth whitening preparations were considered the standard. The treatment was usually performed in a dentist's or dental hygienist's office and involved applying a concentrated hydrogen peroxide-based bleaching solution followed by exposure to short-wavelength light. This type of bleaching can produce visibly satisfactory results with a short application time of between 5 and 60 minutes. However, due to the expert supervision by dentally trained personnel, these treatments are comparatively expensive. Furthermore, treatment with hydrogen peroxide carries a number of side effects, such as increased tooth sensitivity for an extended period after treatment, for example, to temperature fluctuations or acidic foods.Some patients also report occasional, electrically feeling stinging sensations in the teeth, which can occur without any apparent trigger.

[0005] In the past, hydrogen peroxide concentrations of up to 40% were used in dental settings. It is obvious that the application of such concentrated hydrogen peroxide-based tooth whitening solutions must be accompanied by a number of protective measures for the teeth, such as coating the teeth and protecting the gums from the bleaching agents. However, hydrogen peroxide concentrations approved for home use are so low that achieving satisfactory tooth whitening is difficult. In recent years, the use of organic acids, namely phthalimidoperoxycaproic acids (PAP), has proven effective as a replacement for hydrogen peroxide. EP 1 55683 A1 (Thornwaithe DW, et al.) describes the use of PAP. A particular advantage of using PAP is that it neither weakens the enamel nor excessively irritates the oral mucosa.

[0006] WO 2024 / 062286 (Wälchli, A., et al.) describes a component system and method for producing a tooth whitening preparation based on an organic acid, specifically a peroxycarboxylic acid dissolved in aqueous solution. The peroxycarboxylic acid, as the active ingredient, has a low pH value below 7. Ideally, the peroxycarboxylic acid is brought to a physiologically suitable pH value immediately before application, preferably by adding an alkaline activating component. The activating component adjusts the pH of the active ingredient to a range between 7 and 10.5, thus making it ready for use. This two-component system is ideal for use in a point-of-care setting, especially since handling an activating component involves handling a base with a pKB value of at most 4.

[0007] Thus, alternatives to treatment with hydrogen peroxide in the point-of-care setting, i.e., in the in-office bleaching environment, are available, which overcome the disadvantages of hydrogen peroxide.

[0008] There is still a need for a teeth whitening preparation that offers similarly reliable results as a point-of-care treatment, but is suitable for self-treatment, i.e., for home use, and does not require supervision by medically trained personnel.

[0009] Description of the invention

[0010] One object of the invention is to avoid at least one of the disadvantages of the known invention.

[0011] It is therefore an object of the present invention to provide a component system and an applicator system for the targeted application of a physiologically compatible tooth whitening preparation, particularly for self-treatment, which overcomes at least one disadvantage of the known method.

[0012] A particular objective of the present invention is to provide an applicator system of the type mentioned above that can be safely used in the home environment and delivers reliable results comparable to an in-office treatment.

[0013] A further object of the present invention is to provide a corresponding applicator system, as described above, which enables the handling of chemicals bearing a hazard label in accordance with EC Regulation 1272 / 2008 without endangering the user.

[0014] At least one of these tasks was solved using an applicator system according to the characterizing part of the independent claims.

[0015] One aspect of the present invention relates to an applicator system for the targeted application of a physiologically compatible tooth whitening preparation. The applicator system is particularly preferably designed for the targeted application of a physiologically compatible tooth whitening preparation for self-treatment.

[0016] The applicator system comprises a first compartment containing an organic tooth whitening agent. It further comprises a second compartment containing an alkaline activating component. It also includes a separating structure that, in a first state, separates the first and second compartments from each other, in particular in a fluid-tight manner. The separating structure is designed such that it can be transformed into a second state. In the second state, the separating structure is permeable in at least one fluid direction, allowing the organic tooth whitening agent and the alkaline activating component to be miscible. Particularly preferably, the separating structure is permeable in both fluid directions in the second state, i.e., from the first to the second compartment and from the second to the first compartment.

[0017] In a particular embodiment, the separating structure is designed such that it can be transferred from a first state to a second state by applying a force. In a particular embodiment, the first compartment is designed to receive a first fluid. In particular, the first fluid comprises the organic tooth whitening agent.

[0018] In another particular embodiment, the second compartment is designed to hold a second fluid. In particular, the second fluid is an alkaline activation component.

[0019] In a particular embodiment, the first compartment defines a volume. Preferably, the volume is designed for between 1 and 15 ml, more preferably between 1.5 and 2 ml, and particularly preferably substantially 2 ml of organic tooth whitening agent.

[0020] In another particular embodiment, the second compartment defines a second volume. Particularly preferably, the second volume is suitable for containing the alkaline activation component and defines a volume of between 0.1 and 1 ml.

[0021] In a particular embodiment, the first compartment has a volume ratio relative to the second compartment of between 10 to 1 and 100 to 1, particularly preferably 15 to 1.

[0022] In another special embodiment, the first compartment has a volume ratio to the second compartment of between 16 and 1.

[0023] In a particular embodiment, the organic tooth whitening agent comprises at least one caproic acid. Particularly preferably, the organic tooth whitening agent comprises a peroxycarboxylic acid dissolved in an aqueous solution, particularly preferably an imidoperoxycarboxylic acid, especially PAP.

[0024] In a further particular embodiment, the activation component comprises a base in aqueous solution. The base is particularly preferably selected from the group of inorganic bases, especially from the group consisting of: ammonia, sodium bicarbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, and barium hydroxide. In a particular embodiment, the active ingredient component is located in the first compartment. Preferably, the activation component is located in the second compartment. The two compartments are fluidically connected, wherein, in a first state, the separation structure prevents fluid communication.

[0025] In a particular embodiment, the applicator system comprises a carrier, the carrier preferably being designed as a substantially flat structure. The compartments are formed on the carrier by means of a film, for example, in which the film is designed as a molded part and defines at least two volumes that form the compartments. In a particularly preferred embodiment, the film is bonded to the carrier. In a particular embodiment, the carrier and / or the film are substantially transparent.

[0026] In a particularly preferred embodiment, the film is thermally welded to the substrate. In this embodiment, the separating structure can be formed as an area in which the film is bonded to the substrate, particularly in a detachable bonded manner. The separating structure separates the two compartments. If pressure is applied to one or both of the compartments, a detachable bonded connection in the area of ​​the separating structure can break, allowing a fluid channel to form between the compartments. Partially bonded and welded areas between the film and the substrate would be suitable for this embodiment.

[0027] Alternatively and / or additionally, the film is thermally bonded to the substrate. In this embodiment as well, the separation structure can be formed as an area in which the film is detachably bonded to the substrate.

[0028] In a particular embodiment, the activation component comprises a base in solution with a base constant pKb of at most 4. Preferably, a base is used that is sufficient to neutralize the acidic pH of the active ingredient component and preferably to shift it into the alkaline range. Depending on the strength of the base, a different predefined amount is required to adjust the active ingredient component to a suitable, physiologically acceptable pH. A particular advantage of the invention is that much higher concentrations of the organic tooth-whitening agent, especially PAP, can be used, making the tooth whitening process more effective and / or longer lasting. The correspondingly larger amount of PAP can be made ready for use by adjusting its pH to a physiologically acceptable pH with a base in solution in the form of the activation component.

[0029] The device according to the invention ensures that the components can only be applied at a physiologically compatible pH value. In particular, the strong base is only accessible via the connection between the first and second compartments, i.e., after the acidic active ingredient component and the basic activating component have each exerted a buffering effect on each other at a physiologically compatible pH value. The applicator system according to the invention makes such tooth whitening agents safe for self-treatment and direct distribution to users.

[0030] Preferably, the physiologically acceptable pH value lies between 8.5 and 10.5, particularly between 8.5 and 9.5.

[0031] In a particular embodiment, the active ingredient component comprises at least one caproic acid as an organic tooth-whitening agent. Particularly preferably, this is a peroxycarboxylic acid, which is further preferably an imidoperoxycarboxylic acid. The organic tooth-whitening agent PAP is particularly preferred. A suitable organic tooth-whitening agent is, for example, 6-(phthalimido)peroxyhexaic acid or, according to IIIPAC, 6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanperoxyic acid. For the sake of simplicity, the common abbreviation PAP is used in this application to denote all phthalimidoperoxycaproic acids suitable for the present application. An advantage of PAP is its good tolerability, even at higher concentrations.

[0032] In a particular embodiment, the separating structure comprises at least one predetermined breaking point. The predetermined breaking point is particularly preferably designed to allow the separating structure to be converted from the first to the second state. The predetermined breaking point is particularly preferably designed such that it is capable of converting the separating structure from the first to the second state by the application of force.

[0033] In another particular embodiment, the separating structure is formed by a detachable connection. The transition from the first to the second state can then be accomplished, for example, by releasing the detachable connection. For instance, an adhesive force between the separating structure and a support can be overcome by applying force, such as pressure to one or both of the compartments.

[0034] In a particular embodiment, the separation structure defines at least in the second state a lumen which fluidically connects the first compartment and the second compartment in the second state.

[0035] In a particular embodiment, the separating structure is designed such that, in the second state, it is able to create a fluid connection between the first and second compartments, which is permeable in both directions, allowing a fluid to flow from the first compartment into the second compartment and back again. Particularly preferably, the separating structure is designed such that it forms a connecting lumen between the first and second compartments when it has been transitioned into the second state. Particularly preferably, this lumen is tapered in diameter relative to the first and / or the second compartment. Due to the tapered lumen between the first and second compartments, a Venturi effect is created when pressure is applied to one compartment, causing a fluid to flow from the first to the second, or vice versa.This can be particularly advantageous for mixing the tooth whitening agent with the activation component.

[0036] In a particular embodiment, the applicator system has a longitudinal extension with a distal and a proximal end. For the purposes of the present invention, the distal end can be considered the end of the applicator system that is farther away from the user at the moment of application, while the proximal end can be considered the end that is relatively closer to the user at the moment of use, i.e., for example, the end at which the applicator is gripped.

[0037] In a particular embodiment, the longitudinal extension has a plurality of lumens. These lumens comprise at least the first and second compartments. Further lumens may be provided, each distinguished from the others by connections that taper in diameter. Such a plurality of lumens can be particularly helpful, for example, for dosing the tooth-whitening preparation or can have advantageous effects on the mixing of the tooth-whitening agent with the activating component. When passing through a taper, turbulence effects can occur, which enable particularly good mixing.

[0038] In a particular embodiment, the organic whitening agent and / or the activation component includes an indicator that changes color when ideal mixing between the organic whitening agent and the alkaline activation component is achieved. For example, when transferring the separation structure from the first state to the second state, an initial color difference can already be observed in a marginal area where the two fluids begin to mix. A complete color change then occurs when a specific, physiologically compatible pH value of the whitening preparation has been reached.

[0039] In an alternative and / or supplementary embodiment, the first and / or second compartment has an immobilized indicator inside it, i.e., the inner walls of the first and / or second compartment are at least partially coated with an indicator.

[0040] For the purposes of the present invention, a tooth whitening preparation can be understood as a mixture containing an activated organic tooth whitening agent and an alkaline activating component. Particularly preferably, further excipients are also included. These excipients can be contained in the first and / or second compartment of the applicator system. In this sense, for example, the organic tooth whitening agent can be understood as a mixture of the organic tooth whitening agent in the form of caproic acid and at least one excipient. Similarly, the alkaline activating component in the second compartment can be a mixture of the alkaline activating component, i.e., for example, a suitable base such as NaOH, and one or more suitable further excipients and / or solvents.

[0041] In a particular embodiment, the applicator system according to the invention comprises at least one further compartment, e.g., a third compartment. The third compartment may contain an auxiliary substance. For example, the third compartment may contain an indicator which, after complete mixing of the first compartment with the second compartment, is also fluidically connected to the first and / or the second compartment via a second separating structure, so that the indicator is able to show whether the mixture has a physiologically acceptable pH value. In a particular embodiment, the applicator system comprises an application tip. Preferably, the application tip has a predetermined breaking point. For example, the predetermined breaking point of the application tip may be suitable for opening a hermetically sealed applicator system and enabling the application of a tooth whitening preparation.

[0042] In a particular embodiment, the application tip tapers from proximal to distal. More preferably, the application tip tapers from proximal to distal in a frustoconic manner. The application tip is particularly well-suited for enabling, for example, targeted and / or metered application of the tooth whitening preparation. The application tip allows, for example, a single drop of the tooth whitening preparation to be applied precisely to each individual tooth.

[0043] In a particular embodiment, the separation structure includes a mixing element. The mixing element can be, for example, a geometric structure that swirls a fluid flow from the first to the second compartment, or from the second to the first compartment, as it passes through. Suitable geometric structures can be, for example, elements arranged at an angle relative to the longitudinal extent of the applicator. Sieves and / or water vortexers are also suitable.

[0044] In a particular embodiment, the separating structure comprises a mixing element that is essentially elastic. This mixing element, for example, has rigid structures which, when broken, create a fluid connection between the two compartments. Thus, for instance, applying a force to the separating structure can compress the mixing elements and break the rigid structures within them. The breaking of these rigid structures creates openings in the separating structure, thereby transitioning it into the second state.

[0045] In a particular embodiment, the separating structure between the first compartment and the second compartment is arranged and tapered.

[0046] In another particular embodiment, the separating structure includes a valve. The valve is preferably designed to allow fluid to flow in only one direction. Such one-way valves are known in practice. For example, a corresponding overpressure can exist in one compartment. This overpressure can enable the valve to close. The valve can be opened by pressure from one compartment. For example, by compressing the second compartment, its fluid can be forced through the valve into the first compartment. Such a valve can also essentially prevent the backflow of a fluid into a compartment from which it has been forced out.

[0047] In another particular embodiment, the valve is designed to be reversibly switched to the second state by applying force to the separating structure. For example, compressing the valve can allow fluid to flow between the compartments. With an elastic design of the separating structure, releasing the compression would close the valve again. In operation, for example, the separating structure could be compressed with one hand using a pincer grip, thus switching it to the second state, while the other hand could generate fluid movement between the first and / or second compartment by pressing on it. Repeated pressing can thus facilitate the mixing of the two components, i.e., the organic tooth whitening agent and the alkaline activating component.

[0048] In a particular embodiment, the first and / or the second compartment is designed to be compressible. For this purpose, the first and / or second compartment can be made of a compressible plastic. Alternatively and / or additionally, individual elements of the first and / or the second compartment can be designed to be compressible. For example, a compartment can have relatively rigid side walls but a compressible cover area. Suitable plastics are known to those skilled in the art.

[0049] In a particular embodiment, the applicator system is formed in one piece.

[0050] In a particular embodiment, the applicator system is multi-part, in particular two- or three-part.

[0051] In a further particular embodiment, the applicator system comprises a force-acting means for exerting force on the first compartment and / or the second compartment and / or the separating structure. For example, a plunger can be provided as the force-acting means. The plunger can be suitable for exerting sufficient force on the separating structure to convert it into the second state, for example, by displacing the plunger along the longitudinal extension of the applicator system. For this purpose, the plunger can, for example, be pushed or pulled into the effective area of ​​the separating structure.

[0052] In another special embodiment, the applicator system includes a longitudinal bearing designed to guide the plunger.

[0053] In this embodiment and its variants, the applicator system can be operated similarly to a syringe. Accordingly, the plunger can perform a dual function. For example, the plunger can be designed to allow the separation structure to transition into its second state when it is withdrawn relative to the applicator. Subsequently, when applying the whitening preparation, the plunger can be pushed back into the applicator system so that it can be used to apply the whitening preparation to the teeth. The plunger can have one or more flanges to, for example, assist in the mixing of the two fluids or to prevent accidental withdrawal of the plunger from the applicator system.

[0054] In a particular embodiment, the plunger is essentially cylindrical. Alternatively and / or additionally, further structures, such as stops, flanges, pins, grooves, etc., can be provided on the plunger, which are capable of interacting with corresponding counterparts in the applicator or can support special purposes, such as facilitating mixing.

[0055] In a particular embodiment, the plunger is hollow. Preferably, the hollow plunger defines a lumen that serves as a compartment. This lumen can, for example, define the first and / or the second compartment. In this embodiment, the separation structure would be located between the first or second compartment and the lumen of the plunger, forming the corresponding second or first compartment. The separation structure could, for example, be switched to the second state by moving the plunger. Repeatedly moving and retracting the plunger can significantly facilitate the mixing of the two fluids.

[0056] In a particular embodiment, the first compartment is designed to be movable relative to the second compartment. Particularly preferably, the first compartment is designed to be movable relative to the second compartment via the separating structure, such that this movement can serve as a force to transfer the separating structure from the first state to the second state.

[0057] In a particularly preferred embodiment, the first compartment is rotatable relative to the second compartment. Particularly preferably, the separating structure is formed within a screw thread between the first and second compartments. Rotation within the screw thread converts the radial force of the screw movement into a normal force within the screw thread, thus perforating, for example, the separating structure. This allows, for example, a fluid connection between the first and second compartments.

[0058] In a particular embodiment, the first compartment and / or the second compartment is defined at least section by a substantially elastic membrane.

[0059] In a particular embodiment, the separation structure is designed to generate turbulence in a fluid passing through the separation structure in the second state, i.e., flowing from the first to the second compartment and / or vice versa.

[0060] In a particular embodiment, the applicator system has a proximal end which has an end geometry selected from the group consisting of: right-angled, beveled or round.

[0061] In a particular embodiment, the second compartment has a shape selected from the group consisting of: cylindrical, tapering conically towards the proximal end, tapering conically towards the distal end, teardrop-shaped, spherical, blister-like, conical, frustoconic or bulbous.

[0062] In a particular embodiment, the applicator system is designed in three parts, wherein the first compartment is formed by a first part, the second compartment by a second part, and the separating structure by a third part. In particular, the separating structure can be designed to be positioned between the first and second parts. Preferably, it has means capable of creating a positive fit with the first and / or second part. In a particularly preferred embodiment, creating the positive fit simultaneously transforms the first state into the second state. The means capable of creating a positive fit with the first and / or second part can, for example, comprise a thread.

[0063] It is obvious to a person skilled in the art that all of the aforementioned special embodiments can be combined in any way in an implementation of the teaching according to the invention, provided that they do not exclude each other.

[0064] Structural features are also disclosed to a person skilled in the art from the methods described below, which can be used as special embodiments for an applicator system according to the invention.

[0065] Another aspect of the present invention relates to a method for providing an applicator system. In particular, it is an applicator system as described above. The applicator system is suitable for the targeted application of a physiologically compatible tooth whitening preparation, especially for the targeted application of a physiologically compatible tooth whitening preparation for self-treatment.

[0066] The process includes the step of transferring a separation structure, which is arranged between a first compartment containing an organic tooth whitening agent and a second compartment containing an alkaline activation component, from a first state in which both components are fluid-tightly separated from each other, to a second state in which the separation structure is permeable in at least one fluid direction.

[0067] The process further includes the step of mixing the organic tooth whitening agent with the alkaline activation component.

[0068] In a particular embodiment, the method comprises passing the fluid through a constriction between the first and second compartments. Passing a fluid through the constriction can, for example, facilitate the mixing of the two fluids by means of a Venturi effect. Passing the fluid through the constriction multiple times is particularly preferred, so that the organic tooth-whitening agent and the alkaline activating component are mixed by pressure differentials. In a particular embodiment, the method is purely cosmetic and not medical or therapeutic.

[0069] In a particular embodiment, the method is intended for use by a layperson, i.e., a user without medical knowledge.

[0070] Another aspect of the present invention relates to the use of an applicator system for the targeted application of a physiologically compatible tooth whitening preparation, in particular for the targeted application of a physiologically compatible tooth whitening preparation for self-treatment. This use comprises providing an applicator with a first compartment and a second compartment, as well as with a separating structure which fluid-tightly separates the first compartment and the second compartment from each other in a first state, and wherein the separating structure is designed such that it can be transformed into a second state in which the separating structure is permeable in at least one fluid direction, so that a fluid connection exists between the first compartment and the second compartment.The device further provides for the provision of an organic tooth-whitening agent, in particular a peroxycarboxylic acid, especially an imidoperoxycarboxylic acid, preferably PAP, dissolved in an aqueous solution in the first compartment. It further provides for the provision of an alkaline activating component, in particular a base in aqueous solution selected from the group of inorganic bases, further specifically from the group consisting of: ammonia, sodium bicarbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, and barium hydroxide, in the second compartment. The organic tooth-whitening agent and the alkaline activating component are fluid-tightly separated from each other in the first state and miscible in the second state, so that a physiologically compatible tooth-whitening preparation is formed from the mixture of the organic tooth-whitening agent and the alkaline activating component.

[0071] Another aspect of the present invention relates to a component set comprising an applicator system of the type described above and at least one application aid. In a particular embodiment, the application aid is a brush and / or spatula for distributing and / or applying the physiologically compatible tooth whitening preparation. In a further particular embodiment, the application aid is a splint, for example an occlusal splint, which is designed to substantially enclose the teeth and to receive the physiologically compatible tooth whitening preparation, or to maintain it in contact with the teeth for a defined period of time.

[0072] The invention will now be explained in more detail using specific embodiments and figures, without being limited to these.

[0073] A person skilled in the art will discover further advantageous embodiments of the present invention from studying these figures and exemplary embodiments.

[0074] The figures are schematic, and for ease of understanding, analogous elements have been given the same reference symbol.

[0075] Character description

[0076] They show:

[0077] Figure 1 shows an embodiment of an applicator system according to the invention;

[0078] Figure 2a shows an alternative embodiment of an applicator system according to the invention;

[0079] Figure 2b Applicator system of Fig. 2a in top view;

[0080] Figure 2c Applicator system of Fig. 2a in side view;

[0081] Figure 3a shows another alternative embodiment of an applicator system according to the invention;

[0082] Figure 3b shows the applicator system of Figure 3a, and how it can be used;

[0083] Figure 3c shows the applicator system of Figure 3a as it is prepared for application; Figure 4a shows an alternative embodiment of an applicator system according to the invention;

[0084] Figure 4b shows the applicator system of Figure 4a in use;

[0085] Figure 4c shows the applicator system of Figure 4a in use;

[0086] Figure 5a shows a possible design for the second compartment;

[0087] Figure 5b shows an alternative possible design for the second compartment;

[0088] Figure 5c shows another alternative design for the second compartment;

[0089] Figure 5d shows another alternative design for the second compartment;

[0090] Figure 6a shows an embodiment of a proximal end of the applicator system according to the invention;

[0091] Figure 6b shows an alternative embodiment of a distal end of an applicator system according to the invention;

[0092] Figure 6c shows a further alternative embodiment of a distal proximal end of an applicator system according to the invention;

[0093] Figure 6d shows a further alternative embodiment of a proximal end of an applicator system according to the invention;

[0094] Figure 7 shows another special embodiment of an applicator system according to the invention;

[0095] Figure 8a shows another special embodiment of an applicator system according to the invention;

[0096] Figure 8b shows a further embodiment of an applicator system according to the invention;

[0097] Figure 8c shows a further embodiment of an applicator system according to the invention;

[0098] Figure 9a shows a further embodiment of an applicator system according to the invention; Figure 9b shows the applicator system of Figure 10a with an intact tip;

[0099] Figure 10a shows a further embodiment of an applicator system according to the invention;

[0100] Figure 10b shows the applicator of Figure 11a in use

[0101] Figure 11a shows a special embodiment for the separating structure, and

[0102] Figure 11b shows a longitudinal cross-section through the embodiment of Fig. 11a.

[0103] Implementation of the invention

[0104] Figure 1 schematically shows a possible embodiment of an applicator system 1 according to the invention for the targeted application of a physiologically compatible tooth whitening preparation. The applicator system 1 is designed for self-treatment, i.e., for home use. It ensures that the initially unactivated components, namely an organic tooth whitening agent and an alkaline activating component, cannot be directly contacted by the user, except through intended use. The applicator system 1, as shown in Figure 1, can be individually packaged or, as indicated in the figure, part of a package, e.g., a blister strip containing multiple applicator systems 1 extending transversely to the longitudinal dimension of the applicator system 1.For the purposes of the present invention, the longitudinal extent is defined as the length of the longest axis of the applicator system 1. In this example, the longitudinal extent is horizontal to the plane of view. The present applicator system 1 essentially comprises a first compartment 2 and a second compartment 3. The first compartment 2 is designed to hold a first fluid and to seal it essentially hermetically from the environment and the second compartment 3 until its intended use. The second compartment 3 is designed accordingly to hold a second fluid and to seal it hermetically from the environment and the first fluid. The first compartment 2 and the second compartment 3 are separated from each other by a fluid-tight separating structure 4. This defines a first state of the applicator system 1 in which the two fluids in compartments 2 and 3 cannot come into contact with each other.In the present example, the applicator system 1 is essentially made of plastic. The applicator system 1 is designed as a blister pack, and both the first compartment 2 and the second compartment 3 are each mounted on a support 7, for example, a rigid plastic support 7 or an aluminum support 7. The support 7 can be a rigid structure. For example, the support 7 can be made of a relatively harder plastic. Alternatively, the support 7 can also consist of a relatively thicker plastic layer. The corresponding compartments 2 and 3 can then be formed from a relatively thinner plastic layer. Ideally, the compartments 2 and 3 are formed from a plastic layer that can be compressed by applying force. Such a force can also be suitable for transitioning the separating structure 4 from this first state to a second state.In this second state, the separation structure 4 is permeable in at least one fluid direction A. In this second state, the first fluid and the second fluid can mix with each other.

[0105] In the present example, the first compartment 2 has a first wall 5. The second compartment 3 has a second wall 6. The first wall 5 and the second wall 6 can also be formed as a single piece. It is also conceivable that the first compartment 2 with the first wall 5 and the second compartment 3 with the second wall 6 are manufactured separately in production processes and subsequently joined together on the support 7. The separating structure 4 could then be part of the first compartment 2 or the second compartment 3 until it is joined to the separating structure 4. The separating structure 4 can also be formed in two pieces and only assume its final function of maintaining the first state by joining the first compartment 2 to the second compartment 3.

[0106] For the purposes of the present invention, the proximal end is defined as the end facing the user during intended use. In the example shown in Figure 1, the proximal end is located on the right side, while the distal end is located on the left side. The proximal end of the applicator system 1 additionally has two bending sections 8 and 9. The bending sections 8 and 9 can be designed, for example, to facilitate fluid extraction. For instance, during operation, a first bending section 8 can be angled away from the support 7, i.e., bent in or out of the plane under consideration, and thus used as a pressure aid for the second compartment 3. The second bending section 9 can then be angled away from the first bending section 8, e.g.,Opposite to the first bend between the support 7 and the first bending region 8, the second bending region 9 defines a tab that can be grasped by the user and used to compress the second compartment 3. It is also conceivable that the first bending region 8 and the second bending region 9 are bent at the same angle, and then the outer edge, i.e., the proximal end of the applicator 1, can be used to selectively apply a force to the separation structure 4 and convert it into the second state.

[0107] The separating structure 4 is ideally made of a material that allows it to be weakened reversibly or irreversibly so that it is no longer fluid-tight. This can be achieved, for example, by incorporating appropriately brittle elements into the separating structure 4. While conventional plastic parts exhibit a certain degree of elasticity, the brittle elements would break under the influence of a force.

[0108] Alternatively, the separating structure 4 can also be designed as a diaphragm or membrane. When, for example, the second compartment 3 is compressed, the pressure exerted on the diaphragm or membrane would be sufficient to cause it to rupture and force the contents of the second compartment 3, i.e., the fluid, into the first compartment 2.

[0109] In the fluid direction A of the applicator system 1, a distal section 11 tapers towards an application tip 10 in the fluid direction A shown. In the present example, the distal section 11 is shown as a separate area from the first compartment 2. The distal section 11 can also be separated from the first compartment 2, for example, by a second separating structure (not shown). This can ensure, for example, that a mixed tooth whitening preparation is only transferred to the application area when it is completely mixed, preventing accidental leakage of tooth whitening preparation or incompletely mixed fluids from the first or second compartment. However, it is also conceivable that the distal section 11 is formed as a single piece and fluidically connected to the first compartment 2. In the present example, the application tip 10 is also shown as a separate part.In the present example, the application tip 10 consists of an L-shaped tube which is materially connected to the distal end of the distal region 11 and opens a channel to the lumen of the distal region 11, so that a tooth whitening preparation can be applied through the application tip 10. Optionally, the application tip 10 can already be pre-positioned on the applicator system 1 or added subsequently, for example by using a defined weakening of the distal region 11 to push the application tip 10 through and prepare the applicator 1 for use.

[0110] Optionally, the application tip 10 can also have a weakening, e.g. in the form of a predetermined breaking point (not shown in Figure 1), in order to release the hermetic locking of the applicator 1 and make it available for use.

[0111] A specific advantage of blister packaging is that the contents are visible from the outside when a largely transparent plastic is used. This can be utilized, for example, by adding an indicator to one of the two fluids in the first compartment (2) or the second compartment (3). If the whitening preparation is then mixed by combining the two fluids, a color change can indicate that the whitening preparation is now within a physiologically compatible pH range and can be used safely.

[0112] In the present example, the support 7, the first bending section 8, and the second bending section 9 can be formed from a molded plastic part. The first compartment 2, the second compartment 3, and the distal section 11 can be bonded to this rigid plastic part as a film, making the compartments correspondingly elastic. For simplified guidance and use of the applicator 1, the application tip 10 is also made of a rigid plastic. Alternatively, the application tip 10 can also be formed from a tapered end of the distal section 11, similar to a piping bag.

[0113] In a preferred embodiment, the application tip 10 and / or the distal area 11 can be designed for precise droplet dispensing.

[0114] The first compartment 2 contains the organic tooth whitening agent as a gel, for example, through a gelling agent with a concentration of 13.6 wt% PAP. Suitable gelling agents include, for example, cellulose-based gelling agents.

[0115] The second compartment 3 contains, for example, dilute sodium hydroxide solution (25 wt% NaOH) in aqueous solution. Compartments 2 and 3 are hermetically sealed in a first state. A second state allows for the creation of a fluid connection between the first and second compartments. This second state is made possible by an action on the separation structure 4.

[0116] Figure 2a shows an alternative embodiment of an applicator system 1 according to the invention. This applicator system 1 is also designed as a blister. Its longitudinal extension runs obliquely from the lower right to the upper left. The applicator system 1 has two compartments 2 and 3, which are hermetically sealed from one another in a first state by a separating structure 4. The compartments 2 and 3 are formed on an aluminum carrier 7. The aluminum carrier 7 has a tab 15 extending around its circumference.

[0117] The first compartment 2 is defined by a substantially elastic ceiling region 16 and a substantially rigid first edge region 50. The substantially elastic first ceiling region 16 is suitable for being pressed in with the thumb.

[0118] Similarly, the second compartment 3 is defined by a second essentially elastic ceiling area 17 and a second edge area 51. The second elastic ceiling area 17 is also suitable for being pressed in with a finger. This force can be used, for example, to create a fluid connection in a region of the separating structure 4 between the second compartment 3 and the first compartment 2. In this embodiment, the separating area 4 is designed as a detachably bonded area between the two compartments 2 and 3. By applying pressure to the compartments, an adhesive force of the separating structure 4, which connects the separating structure 4 to the aluminum support 7, is released.

[0119] To mix the two fluids in compartments 2 and 3, the first compartment 2 and the second compartment 3 can then be repeatedly compressed, for example by pressing in the ceiling areas 16 and 17. Once sufficient mixing has been achieved, the fluid can be conveyed further in fluid direction A towards the proximal end, where an application tip 10 may be located. The application tip 10 is suitable for applying the tooth whitening preparation precisely to one or more teeth. In this example as well, the application tip 10 may have corresponding predetermined breaking points or other structures that allow the tooth whitening preparation to be dispensed from the applicator system 1.

[0120] A distal area 11 also has a predetermined breaking point 20 in the vicinity of the application tip 10. If the predetermined breaking point 20 tears or breaks off, an opening to the distal area 11 is formed and a mixed fluid in the applicator system 1 can be released to the outside.

[0121] Ideally, the diameter of the application tip 10 and / or the distal section 11 is also adapted to the viscosity of the resulting tooth whitening preparation. For example, the thinner the tooth whitening preparation, the narrower an ideal application tip would be. With very viscous tooth whitening preparations, the application tip can have a correspondingly larger diameter to allow for the flow of the whitening preparation.

[0122] The first compartment 2 is filled with an imidoperoxycarboxylic acid.

[0123] The second compartment is filled with an inorganic base, in particular dilute sodium hydroxide solution in aqueous solution.

[0124] Suitable formulations and excipients for the organic tooth whitening agent and the inorganic base can be found in WO 2024 / 062286, hereby incorporated by reference.

[0125] Figure 2b shows a top view of the applicator system 1 from Figure 2a. The ceiling region 16 is pressed in to eliminate the adhesive force of the separating structure 4 between the first compartment 2 and the second compartment 3. This creates the second state, and the two compartments 2 and 3 are fluidically connected. Subsequently, a predetermined breaking point 20 in the distal region 10 can be broken, and the tooth whitening preparation can be dispensed via the application tip 10. Figure 2c shows a side view of the same applicator system 1. The ceiling region 16 of the first compartment can be thinner compared to a marginal region 50, which facilitates compression of the first compartment. Similarly, a ceiling region 17 of the second compartment can be thinner to facilitate the back-and-forth pumping of the fluid between the compartments 2 and 3 for mixing.Figures 3a to 3c describe, using an example, a possible special embodiment of the applicator system of Figure 2 during the course of application.

[0126] The applicator system in Figure 3a, designed as a blister pack, has a first compartment 2 and a second compartment 3. The first compartment 2 is connected to the second compartment 3 by means of a separating structure 4. The separating structure 4 can contain a membrane that keeps the two fluids in chambers 2 and 3 separate. When pressure 5 is applied to the second compartment 3, the separating structure 4 can rupture, allowing the fluid contained in the second compartment 3 to enter the first compartment 2. The blister pack is mounted on a carrier with a tab 15. At the distal end (bottom in Figure 3a), a distal area is formed for applying the tooth whitening preparation.

[0127] Figure 3b illustrates how mixing the two now miscible fluids can be facilitated. For example, the second compartment 3, the first compartment 2, or alternately each compartment can be pressed with a pressure, so that the mixed fluid is forced back and forth between the compartments. Passing the constriction in the area of ​​the separating structure 4 thus facilitates mixing.

[0128] In Figure 3c, the tooth whitening preparation is premixed and the pH value is within a physiologically acceptable range. A predetermined breaking point 20 in the distal region 11 is used to detach a section 18 from the applicator system. The predetermined breaking point 20 can, for example, comprise a recess, a notch, a weakening of the material, or a peelable tab, which accordingly allows the section 18 to be detached.

[0129] If the separation area 18 is detached, the fracture edge 20' extends through the distal area 11. Since the distal area 11 is formed as a channel and defines a lumen, the fluid, and thus the finished tooth whitening preparation, can be forced out through the distal area 11. In the present example, the tooth whitening preparation 100 can be dispensed drop by drop.

[0130] Figure 4a shows an alternative embodiment of an applicator system 1 according to the present invention. The applicator system 1 has a distal region (below in the figure) and a proximal region (above in the figure). A first compartment 2 and a second compartment 3 are bulbous, like a pipette. In the distal region, a carrier 7 is tab-shaped and terminates in a rounded end. The first compartment 2 is held separate from the second compartment 3 in a first state by a separating structure 4 in an hourglass region 28. This hourglass region 28 creates a taper, which is advantageous later when mixing the fluids. The two bulbous compartments 2, 3 each comprise a tooth whitening agent and an activation component.

[0131] In the distal region, a distal section 11 is formed, which is inclined away from a main body of the first compartment 2 at an angle 29. The inclination of the distal section 11 facilitates application. The distal section 11 terminates in a detachable application tip 10, which can, for example, be formed from a plastic part provided with a tear-off tab.

[0132] In Figure 4b, the separation structure 4 has been transformed into its second state. The fluid can now flow freely from the first compartment 2 to the second compartment 3 and vice versa. Repeated movement of the fluid between compartments 2 and 3 passes through the hourglass region 28 and the narrowing of the separation structure 4, which, by means of a Venturi effect, enables improved mixing of the two fluids involved.

[0133] At the distal end, the application tip 10 was torn off, thus opening the applicator system and preparing it for application.

[0134] Figure 4c shows how, for example, the carrier 7 can be used as an aid for squeezing out the contents of the applicator, by, for example, tilting it and using it to press against at least the second compartment 3.

[0135] Figures 5a to 5d show alternative embodiments, such as how a separating structure 4 between the first compartment 2 and a second compartment 3 can be formed. For example, according to Figure 5a, the second compartment 3 can connect to the first compartment 2 in a droplet shape, and the contact surface between the first compartment 2 and the second compartment 3 can be formed as a separating structure 4.

[0136] In Figure 5b, a second compartment 3 is bulging, and the separating structure 4 is formed as a constriction between the first compartment 2 and the second compartment 3. A variant of this is shown in Figure 5c, where the second compartment 3 is teardrop-shaped extending from the proximal end of the first compartment 2. Another alternative embodiment, which may offer safety advantages, is shown in Figure 5d. The second compartment 3 is formed as an inner lumen within the second compartment 2, and the separating structure 4 demarcates the second compartment 3 from the first compartment 2. One advantage is that the activation component, which is stored in the second compartment 3, is subject to safety requirements as a relatively strong base. An arrangement that is not accessible from the outside, as shown in Figure 5d, can further increase product safety against misuse or abuse.

[0137] Figures 6a to 6d show different proximal ends for an applicator system according to the invention. According to the first embodiment shown in Figure 6a, the carrier 7.1 is rounded at the distal edge.

[0138] In Figure 7b, the alternative support 7.2 is cut off obliquely in the distal area.

[0139] In Figure 7c, the distal region of the support 7.3 is also chamfered, although at a less steep angle than in Figure 7d. Alternatively, the distal end of a support 7.4 can also be cut straight, as shown in Figure 7d.

[0140] Figure 7 shows an alternative embodiment of the applicator system according to the invention, in which the applicator is overall teardrop-shaped. The second compartment 3 simultaneously defines the outer shell of the applicator, while the second compartment 3 is formed within the first compartment 2. A chamfered distal region extends at an angle from the distal end of the first compartment 2. This is an implementation such as would be possible, for example, for an arrangement according to Figure 6d. Another embodiment with advantageous geometry is shown in Figures 8a to 8c. In this example, a second compartment is divided into two subcompartments 2.1, 2.2, as shown in Figure 8a. In this example, the subcompartments 2.1, 2.2 are connected to each other via a fluid bridge. The fluid bridge is also a taper. In this example, a fluid in a second compartment 3 can, for example,The fluid is forced into the first compartment 2 via a separating structure that is permeable in only one direction. This prevents the fluid, once forced out of the second compartment 3, from flowing back into it. For mixing, the two subcompartments 2.1 and 2.2 can be pressed alternately, forcing the fluid past the fluid bridge. This results in improved mixing of the tooth-whitening agent, similar to the effects described above. Analogous to the embodiments shown above, the compartments 2.1, 2.2, and 3 are bulbous and mounted on a support 7. They terminate distally in a distal region 11, which is angled away from the first subcompartment 2.1 of the second compartment 2 and ends in an application tip (not shown).

[0141] Figure 8b shows an applicator system in which the entire system tapers from the proximal to the distal region. The carrier 7 is comparatively the widest part. Similarly, the second compartment 3 tapers into the first compartment 2, and this in turn tapers into a distal region 11, which terminates in a detachable applicator tip.

[0142] Figure 8c shows a corresponding applicator solution which, analogous to Figure 8a, divides a second compartment 3 into two subcompartments 2.1 and 2.2, which are connected to each other via a fluid bridge 33. The separating structure 4, which separates a proximal subcompartment 2.2 from the second compartment 3, is designed as a tab that can be released from the outside. When the tab is released, the contents of the second compartment 3 can be forced into the proximal subcompartment 2.2 of the first compartment 2. Analogous to Figure 9a, the fluid bridge 33 can serve as a mixing aid. Application is carried out via the distal region 11 after the detached application tip 10.

[0143] Another alternative embodiment is shown in Figures 9a and 9b, in which an applicator system 1 has two essentially hemispherical compartments 2, 3, which are provided as protrusions on a tab 15. The tab 15 can have a fluid channel 41, as shown in Figure 10a, to dispense a tooth whitening preparation over the fracture edge 20' in the event of a broken-off section. The spherically shaped second compartment 3 can be compressed, whereby a membrane 37 within a separation structure 4 bursts and conveys the contents of the second compartment 3 into the first compartment 2. The first compartment 2 can also be compressed by means of a crease 40, thus facilitating the mixing of the fluids.Figure 10a shows a variant in which the various steps behave analogously, except for a distal area 11 designed as an extension of the first compartment 2, through which a predetermined breaking point extends, which enables the separation of the separation area 18 and exposes a lumen of the distal area 11, so that a fluid conveyed in fluid direction A can exit the applicator through this.

[0144] Another alternative embodiment is shown in Figures 10a and 10b. In a further development of Figures 9a and 9b, a spherically shaped first compartment 2 is formed on a support. The support has two tabs 15.1, 15.2 that are movable relative to each other via a bending groove 40. Thus, a first tab 15.1 can be connected to a second tab 15.2 relative to each other via a membrane, e.g., a layer of thermoplastic material on the support, which is essentially flexible. When the bending groove 40 is bent, the spherically shaped second compartment 3, which is mounted in the first compartment 2, is pressed into the first compartment 2, and a membrane arranged between the compartments is torn. Any fluid that was in the second compartment 3 is forced into the first compartment 2 in a fluid direction A1.If this bending motion is repeated at the bend groove 40, with the second compartment 3 being repeatedly pulled out and pushed back into the first compartment 2, homogeneous mixing of the fluids is achieved. Once the fluids are sufficiently mixed, the fluid can be forced out through a distal section 11 by pushing the second compartment 3 into the first compartment 2. Distally, there is a separation section 18, which can be pushed out of the applicator via a predetermined breaking point 20, which is now open due to the break edge 20'.

[0145] Figure 11a shows an alternative embodiment of a separating structure 4 for an applicator system according to the invention. In this example, the separating structure 4 is designed as a separate unit that can be inserted between two compartments. For this purpose, for example, a screw thread 61 or a plug connection 62 can be provided. Naturally, both connections can each include a screw thread or a plug connection. The separating element 4 is fluid-permeable in two directions and can be configured, in the concealed and / or screwed-in state, to provide a second state according to the invention, as described above, in which a fluid connection through the separating structure is enabled.

[0146] Figure 11b shows a special variant of the separation structure according to Figure 11a, in which the lumen of the separation structure 4 comprises a plurality of internal structures 63.1, 63.2, 63.3. The internal structures 63.1, 63.2, 63.3 project into the lumen in such a way that they impede fluid movement A between two compartments. This improves the mixing of two fluids, especially when the fluid is pumped back and forth several times.

[0147] The applicator system according to the invention enables safe handling of a tooth whitening preparation of the type described herein, which can also be used safely and reliably by an untrained user, e.g. in self-treatment.

[0148] The applicators and applicator system according to the invention have a long shelf life because the chemicals are present in their original states and hermetically sealed from one another. Furthermore, they can be packaged and distributed in suitable pre-dosed quantities. With the solution according to the invention, it is possible for a layperson to achieve a level of whitening that is in no way comparable to that achieved in a dental bleaching procedure. Reference list

[0149] 1 applicator

[0150] 2 first compartment

[0151] 3 second compartment

[0152] 4 Separation structure

[0153] 5 first wall

[0154] 6 second wall

[0155] 7 carriers

[0156] 8 first bending area

[0157] 9 second bend area

[0158] 10 application tips

[0159] 11 Distal area

[0160] 15 tab

[0161] 15.1 first tab

[0162] 15.2 second tab

[0163] 16 first ceiling area

[0164] 17 second ceiling area

[0165] 18 Separation area

[0166] 20 Breakaway point

[0167] 20' fracture edge

[0168] 28-hour glass range

[0169] 29 Angle Zone

[0170] 33 Fluid bridge

[0171] 40 Bend groove

[0172] 41 Fluid channel

[0173] 50 first marginal area

[0174] 51 second marginal area

[0175] 61 Screw connection

[0176] 62 Connector 63.1, 63.2, 63.3 Internal structures

[0177] 100 teeth whitening preparations

[0178] Fluid direction

[0179] B Contact pressure

Claims

Patent claims 1. Applicator system (1) for targeted application of a physiologically compatible tooth whitening preparation, in particular for targeted application of a physiologically compatible tooth whitening preparation in self-treatment, comprising: a. A first compartment (2) containing an organic tooth whitening agent; b. A second compartment (3) containing an alkaline activation component; c. A separation structure (4) which separates the first compartment and the second compartment from each other in a first state, in particular separating fluid-tightly, and wherein the separation structure is designed in such a way that it can be transformed into a second state, in particular by means of an application of force, in which the separation structure is permeable in at least one fluid direction (A) so that the organic tooth whitening agent and the alkaline activation component are miscible.

2. Applicator system according to claim 1, wherein: a. the organic tooth whitening agent comprises at least one caproic acid, in particular a peroxycarboxylic acid dissolved in an aqueous solution, which is in particular an imidoperoxycarboxylic acid, preferably PAP, and b. the activation component comprises a base in aqueous solution, selected from the group of inorganic bases, in particular from the group consisting of: ammonia, sodium bicarbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide and barium hydroxide.

3. Applicator system according to any one of claims 1 to 3, wherein the separation structure has at least one predetermined breaking point.

4. Applicator system according to one of claims 1 to 3, wherein the separating structure has a releasable adhesive force, in particular wherein the separating structure is designed to seal an area between the first compartment (2) and the second compartment (3) via the adhesive force.

5. Applicator system according to any one of claims 1 to 5, wherein the applicator system has a longitudinal extension with a distal and a proximal end, in particular wherein the longitudinal extension has a plurality of lumens comprising at least the first compartment and the second compartment.

6. Applicator system according to any one of claims 1 to 6, wherein the applicator system has an application tip, in particular wherein the application tip has a predetermined breaking point.

7. Applicator system according to one of claims 1 to 6, wherein the separation structure comprises a mixing element.

8. Applicator system according to one of claims 1 to 7, wherein the separating structure is arranged between the first compartment and the second compartment and is tapered.

9. Applicator system according to any one of claims 1 to 8, wherein the separation structure has a valve, in particular a valve which is passable by a fluid only in one flow direction.

10. Applicator system according to one of claims 1 to 9, wherein the first compartment and / or the second compartment is / are designed to be compressible.

11. Applicator system according to any one of claims 1 to 10, wherein the applicator system comprises a force means for exerting a force on the first compartment and / or the second compartment and / or the separating structure.

12. Applicator system according to any one of claims 1 to 11, wherein the first compartment is designed to be movable relative to the second compartment, in particular to be movable via the separating structure, such that this movement is suitable for exerting a force to transfer the separating structure from the first state to the second state.

13. Applicator system according to any one of claims 1 to 12, wherein the first compartment (2) and / or the second compartment (3) is / are defined at least section by a substantially elastic membrane.

14. Applicator system according to one of claims 1 to 13, wherein the separation structure is configured to generate turbulence in the second state in a fluid which flows from the first to the second compartment and / or vice versa.

15. Applicator system according to any one of claims 1 to 14, wherein the applicator system has a proximal end which is rectangular, beveled or round.

16. Applicator system according to any one of claims 1 to 15, wherein the second compartment may have a shape selected from the group consisting of: cylindrical, tapering conically towards the proximal end, tapering conically towards the distal end, teardrop-shaped, spherical, bubble-like, conical, frustoconic or bulbous.

17. Method for providing an applicator system according to any one of claims 1 to 16 for the targeted application of a physiologically compatible tooth whitening preparation, in particular for the targeted application of a physiologically compatible tooth whitening preparation in self-treatment, comprising the steps: a. Transitioning a separation structure between a first compartment containing an organic tooth whitening agent and a second compartment containing an alkaline activation component from a first state in which both compartments are fluid-tightly separated from each other to a second state in which the separation structure is permeable in at least one fluid direction; b. Mixing the organic tooth whitening agent with the alkaline activation component.

18. Method for providing an applicator system according to claim 16, comprising passing through a narrowing between the first compartment and the second compartment, in particular passing through the narrowing several times, so that the organic tooth whitening agent and the alkaline activation component are mixed by pressure differences.

19. Use of an applicator system for the targeted application of a physiologically compatible tooth whitening preparation, in particular for the targeted application of a physiologically compatible tooth whitening preparation in self-treatment, comprising the steps: a. Providing an applicator with a first compartment (2) and a second compartment (3), as well as a separation structure (4) which separates the first compartment and the second compartment from each other in a fluid-tight manner in a first state, and wherein the separation structure is designed in such a way that it can be transformed into a second state in which the separation structure is permeable in at least one fluid direction (A) so that a fluid connection exists between the first compartment (2) and the second compartment (3); b. Providing an organic tooth whitening agent, in particular a peroxycarboxylic acid dissolved in an aqueous solution, especially an imidoperoxycarboxylic acid, preferably PAP, in the first compartment; c. Providing an alkaline activating component, in particular a base in aqueous solution selected from the group of inorganic bases, further in particular from the group consisting of: ammonia, sodium bicarbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide and barium hydroxide, in the second compartment, wherein the organic tooth whitening agent and the alkaline activating component are fluid-tightly separated from each other in the first state and are miscible in the second state, so that a physiologically compatible tooth whitening preparation is formed from the mixture of the organic tooth whitening agent with the alkaline activating component.

20. Component set comprising an application system according to one of claims 1 to 15 and an application aid.

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