Spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation and preparation method thereof

Abstract

The present invention discloses a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation and a preparation method thereof. Poria cocos, dandelion leaf, and corn silk are subjected to water extraction, concentration, homogenization with resistant dextrin, maltodextrin, and gum arabic, and spray drying to obtain a composite water-extracted spray-dried powder. Coix seed is subjected to low-temperature roasting and micronization to obtain roasted coix seed micropowder, while citrus peel and fennel seed are separately pulverized. The composite water-extracted spray-dried powder, roasted coix seed micropowder, citrus peel powder, fennel seed powder, and silicon dioxide are subjected to fluidized-bed spray granulation. After drying and cooling below 40°C, cranberry powder is post-added, followed by mixing and sizing. The composition exhibits good dispersibility, low sedimentation, improved flavor, and polyphenol stability, and is suitable for non-therapeutic improvement of a dampness-heavy bodily sensation.

Description

[0001] DESCRIPTION

[0002] Spleen-Strengthening and Dampness-Dispelling Plant Instant Granule Composition for Improving a Dampness-Heavy Bodily Sensation and Preparation Method Thereof

[0003] Technical Field

[0004] The present invention relates to the technical field of dietary-supplement-type plant products, and particularly relates to a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation and a preparation method thereof.

[0005] Background Art

[0006] Excessive internal dampness is a common state description in the fields of traditional wellness preservation and TCM dietary therapy, and is commonly manifested as dampness-heavy bodily sensations such as body heaviness, limb fatigue, postprandial abdominal bloating, sticky sensation in the mouth, loose stools, drowsiness, and thick greasy tongue coating. In modern plant food and dietary-supplement-type products, consumers have a high demand for plant compositions that strengthen the spleen and dispel dampness, clear and drain damp turbidity, and improve dampness-heavy bodily sensations.

[0007] Existing spleen-strengthening and dampness-dispelling products mostly use traditional raw materials such as coix seed, Poria cocos, red adzuki bean, Euryale ferox seed and chenpi in simple combinations. Although such products have a certain dietary-therapy basis, they suffer from the following deficiencies: first, some products are merely ordinary mixed powders or tea bags and produce much sediment and a strong powdery mouthfeel after reconstitution, resulting in low consumer acceptance; second, dampness-dispelling raw materials are mostly grains, roots / rhizomes and herbs, and direct mixing readily produces raw-powder odor, herbal astringency and a dull flavor; third, some combinations focus only on raw materials for water-fluid metabolism, and lack overall improvement in spleen-stomach transportation and transformation, postprandial abdominal bloating, heaviness sensation and loose-stool sensation; fourth, if polyphenol-containing plant raw materials such as cranberry are co-extracted with other plants at a high temperature, color darkening and reduced polyphenol retention can readily occur; fifth, existing products mostly emphasize stacking of ingredients and lack comprehensive verification of spleen-strengthening and dampness-dispelling effects, improvement of dampness-heavy bodily sensationDESCRIPTION

[0008] and reconstitution palatability. Accordingly, a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation and a preparation method thereof are proposed. Summary of the Invention

[0009] To solve the above technical problems, provided are a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation and a preparation method thereof, and the technical solution solves the above problems.

[0010] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation, wherein the plant instant granule composition comprises: a composite water-extracted spray-dried powder, roasted coix seed micropowder, citrus peel powder, fennel seed powder, cranberry powder and granulation excipients; the composite water-extracted spray-dried powder is prepared by subjecting Poria cocos, dandelion leaf and corn silk to water extraction and concentration, mixing the same with resistant dextrin, maltodextrin and gum arabic, and then spray-drying; the roasted coix seed micropowder is prepared by pulverizing coix seed after low-temperature roasting at 100-130°C for 20-45 min; and the cranberry powder is added after fluidized-bed granulation and when a material temperature is reduced to below 40°C;

[0011] calculated based on parts by weight of dry raw plant materials charged, the Poria cocos is 18-30 parts, the coix seed is 15-28 parts, the dandelion leaf is 8-16 parts, the com silk is 8-16 parts, the citrus peel is 5-12 parts, the cranberry is 4-10 parts, and the fennel seed is 2-7 parts; a mass ratio of the composite water-extracted spray-dried powder, the roasted coix seed micropowder, the citrus peel powder, the fennel seed powder and the cranberry powder is 35-60:12-25:5-12:2-6:4-10;

[0012] The granulation excipients comprise resistant dextrin, maltodextrin, gum arabic, hydroxypropyl methylcellulose and silicon dioxide.

[0013] Preferably, calculated based on parts by weight of dry raw plant materials charged, the Poria cocos is 20-26 parts, the coix seed is 18-24 parts, the dandelion leafDESCRIPTION

[0014] is 10-14 parts, the corn silk is 10-14 parts, the citrus peel is 7-10 parts, the cranberry is 5-8 parts, and the fennel seed is 3-5 parts.

[0015] Preferably, in the composite water-extracted spray-dried powder, calculated by weight of solids before spray drying, water-extracted solids of Poria cocos, dandelion leaf and corn silk account in total for 15-40%, resistant dextrin accounts for 25-55%, maltodextrin accounts for 10-30%, and gum arabic accounts for 3-10%.

[0016] Preferably, a D90 particle size of the roasted coix seed micropowder is not greater than 180 pm; and D90 particle sizes of both the citrus peel powder and the fennel seed powder are not greater than 250 pm.

[0017] Preferably, the hydroxypropyl methylcellulose is prepared as an aqueous solution having a mass concentration of 2.0-8.0% for use as a fluidized-bed granulation spray liquid.

[0018] Preferably, particles of 20-60 mesh in the plant instant granule composition account for not less than 75%; the composition forms a uniform dispersion within 90 s after stirring in water at 25°C, and a sedimentation rate after standing for 5 min is not higher than 8.0%.

[0019] A preparation method of a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation adopts a three-stage process of water extraction and spray drying, roasting and micronization, and low-temperature post-addition, and comprises the following steps:

[0020] 51, taking Poria cocos, dandelion leaf and corn silk, adding water for extraction, filtering, combining filtrates and concentrating the same, thereby obtaining a plant water-extract concentrate;

[0021] 52, adding resistant dextrin, maltodextrin and gum arabic to the plant water-extract concentrate, homogenizing and then spray-drying, thereby obtaining the composite water-extracted spray-dried powder;

[0022] 53, pulverizing coix seed after low-temperature roasting to obtain the roasted coix seed micropowder; and separately pulverizing citrus peel and fennel seed to obtain citrus peel powder and fennel seed powder;DESCRIPTION

[0023] 54, mixing the composite water-extracted spray-dried powder, the roasted coix seed micropowder, the citrus peel powder, the fennel seed powder and silicon dioxide, and performing fluidized-bed spray granulation using a hydroxypropyl methylcellulose aqueous solution;

[0024] 55, drying the granulated material and cooling the same to below 40°C, adding cranberry powder, mixing uniformly, and sizing the granules, thereby obtaining the spleen-strengthening and dampness-dispelling plant instant granule composition.

[0025] Preferably, in SI, an amount of water added is 8-12 times the total weight of Poria cocos, dandelion leaf and com silk, an extraction temperature is 75-90°C, and extraction is performed 1-2 times for 60-120 min each time.

[0026] Preferably, in S2, an inlet air temperature for spray drying is 150-175°C, and an outlet air temperature is 75-90°C.

[0027] Preferably, in S4, an inlet air temperature for fluidized-bed granulation is 45-65°C, and a material temperature is 32-45°C; and the obtained spleen-strengthening and dampness-dispelling plant instant granule composition is used in a food, solid beverage, granule, stick-pack powder, capsule filling or dietary-supplement-type plant product for improving a dampness-heavy bodily sensation state for a non-therapeutic purpose.

[0028] Compared with the prior art, the advantageous effects of the present invention are as follows:

[0029] The present invention is not a simple mixture of plant powders; rather, it compounds, in view of common manifestations of excessive internal dampness, coordinated raw materials for strengthening the spleen and percolating dampness, clearing and draining damp turbidity, regulating qi and harmonizing the middle, and harmonizing flavor, thereby improving, for a non-therapeutic purpose, dampness-heavy bodily sensation states such as body heaviness, postprandial abdominal bloating, sticky sensation in the mouth, loose-stool sensation and drowsiness.

[0030] The present invention subjects Poria cocos, dandelion leaf and com silk to waterDESCRIPTION

[0031] extraction and spray drying, so that water-soluble components are more readily released upon reconstitution, thereby avoiding excessive sediment and rough mouthfeel caused by direct reconstitution of coarse powder.

[0032] In the present invention, coix seed is subjected to low-temperature roasting and micronization, so that it is more suitable as a spleen-strengthening and dampness-dispelling basic component in the instant granules, and raw-powder odor and dull grain flavor are reduced.

[0033] The present invention uses citrus peel in combination with fennel seed to improve herbal astringency brought by dandelion leaf, com silk and Poria cocos, and to assist in improving postprandial abdominal bloating sensation.

[0034] In the present invention, cranberry is added after low-temperature processing, thereby avoiding loss of polyphenolic components during common high-temperature extraction, and meanwhile improving the sweet-sour flavor and drinking acceptance of the granules.

[0035] The granules obtained according to the present invention have good reconstitution properties, little sediment and a relatively good taste, and are suitable for preparing solid beverages, granules, stick-pack powders, capsule fillings or dietary-supplement-type plant products.

[0036] Brief Description of the Drawings

[0037] FIG. 1 is a flowchart of preparation steps of the spleen-strengthening and dampness-dispelling plant instant granule composition of the present invention for improving a dampness-heavy bodily sensation.

[0038] Specific Embodiments

[0039] The following description is provided to disclose the present invention such that those skilled in the art can carry out the present invention. The preferred examples in the following description are by way of illustration only, and other obvious modifications will occur to those skilled in the art.

[0040] The resistant dextrin, maltodextrin, gum arabic, hydroxypropyl methylcellulose and silicon dioxide are all food-grade raw materials and are commercially available.

[0041] The amounts of Poria cocos, dandelion leaf and com silk in the followingDESCRIPTION

[0042] examples are all charged amounts of dry raw plant materials. The actual yield of the composite water-extracted spray-dried powder may be controlled according to the yield of water-extracted solids from the raw plants and the amount of carriers added, so as to satisfy the mass ratio requirement of the principal components in the final dry granules.

[0043] Example 1

[0044] This example provides a spleen-strengthening and dampness-dispelling plant instant granule composition, which is prepared from the following raw materials based on 1000 g of preparation charging amount:

[0045] Poria cocos 170 g, coix seed 160 g, dandelion leaf 95 g, com silk 95 g, citrus peel 70 g, cranberry fruit powder 60 g, fennel seed 30 g, resistant dextrin 180 g, maltodextrin 90 g, gum arabic 30 g, hydroxypropyl methylcellulose 8 g, and silicon dioxide 12 g.

[0046] The parts by weight of the above raw materials charged correspond to: Poria cocos 17 parts, coix seed 16 parts, dandelion leaf 9.5 parts, com silk 9.5 parts, citrus peel 7 parts, cranberry 6 parts, and fennel seed 3 parts.

[0047] The preparation method adopts the three-stage process of water extraction and spray drying, roasting and micronization, and low-temperature post-addition, and specifically comprises the following steps:

[0048] 51, water extraction step: Poria cocos 170 g, dandelion leaf 95 g and corn silk 95 g were taken, 10 times the amount of purified water was added, extraction was performed at 85°C for 90 min, and filtration was performed; 8 times the amount of purified water was further added to the filter residue, extraction was performed at 85°C for 60 min, and filtration was performed; the two filtrates were combined to obtain a plant water-extract concentrate. The amount of water added was 10 times the total weight (360 g) of Poria cocos, dandelion leaf and corn silk, the extraction temperature was 85°C, and extraction was performed twice, for 90 min the first time and 60 min the second time.

[0049] 52, spray-drying step: the combined filtrate was concentrated under reducedDESCRIPTION

[0050] pressure below 60°C to a solids content of 20% (mass fraction), resistant dextrin 180 g, maltodextrin 90 g and gum arabic 30 g were added, and after stirring and homogenizing for 10 min, spray drying was performed. The spray-drying conditions were: inlet air temperature 160°C and outlet air temperature 82°C, thereby obtaining the composite water-extracted spray-dried powder.

[0051] Calculated by total weight of solids before spray drying, the combined water-extracted solids of Poria cocos, dandelion leaf and corn silk accounted for about a proportion within 15-40% of the total solids; resistant dextrin was within about 25-55%; maltodextrin was within about 10-30%; and gum arabic was within about 3-10%.

[0052] 53, roasting and micronization step: coix seed 160 g was placed in a hot-air oven and roasted at 110°C for 30 min; after cooling, it was pulverized and passed through a 100-mesh sieve (corresponding to a D90 particle size not greater than 180 pm), thereby obtaining roasted coix seed micropowder.

[0053] Citrus peel 70 g and fennel seed 30 g were separately dried below 45°C until the moisture content was not higher than 6.0%, pulverized and then passed through an 80-mesh sieve (corresponding to a D90 particle size not greater than 250 pm), thereby obtaining citrus peel powder (Citrus sinensis peel powder) and fennel seed powder (Foeniculum vulgare seed powder), respectively.

[0054] 54, fluidized-bed granulation step: the composite water-extracted spray-dried powder, the roasted coix seed micropowder, the citrus peel powder, the fennel seed powder and silicon dioxide 12 g were charged into a fluidized bed and premixed uniformly. Hydroxypropyl methylcellulose 8 g was prepared as an aqueous solution having a mass concentration of 4.0% for use as a fluidized-bed granulation spray liquid. The inlet air temperature of the fluidized bed was 58°C, the material temperature was controlled at 38-42°C, and spray granulation was performed. The concentration of the hydroxypropyl methylcellulose aqueous solution was 4.0%.

[0055] 55, low-temperature post-addition and sizing step: the granulated material was dried below 45°C until the moisture content was not higher than 4.0%, cooled toDESCRIPTION

[0056] below 35°C, cranberry fruit powder 60 g (Vaccinium macrocarpon fruit powder) was added, the mixture was mixed for 15 min, and the granules were sized so that 20-60 mesh particles accounted for not less than 80%, thereby obtaining the spleen-strengthening and dampness-dispelling plant instant granule composition.

[0057] The obtained product was uniform granules formed after granulation of the composite water-extracted spray-dried powder, roasted coix seed micropowder, citrus peel powder, fennel seed powder and cranberry powder, wherein a mass ratio of the respective components was approximately: composite water-extracted spray-dried powder: roasted coix seed micropowder: citrus peel powderfennel seed powder: cranberry powder ~ 45:16:7:3:6, which falls within the mass ratio range of 35-60:12-25:5-12:2-6:4-10.

[0058] Example 2

[0059] This example provides a spleen-strengthening and dampness-dispelling plant instant granule composition, which is prepared from the following raw materials based on 1000 g of preparation charging amount:

[0060] Poria cocos 190 g, coix seed 140 g, dandelion leaf 85 g, com silk 110 g, citrus peel 60 g, cranberry extract 50 g, fennel seed 25 g, resistant dextrin 200 g, maltodextrin 88 g, gum arabic 32 g, hydroxypropyl methylcellulose 8 g, and silicon dioxide 12 g.

[0061] The parts by weight of the above raw materials charged correspond to: Poria cocos 19 parts, coix seed 14 parts, dandelion leaf 8.5 parts, corn silk 11 parts, citrus peel 6 parts, cranberry 5 parts, and fennel seed 2.5 parts.

[0062] The preparation method was substantially the same as that of Example 1, and included a water extraction step (SI), a spray-drying step (S2), a roasting and micronization step (S3), a fluidized-bed granulation step (S4), and a low-temperature post-addition and sizing step (S5).

[0063] The main differences from Example 1 were as follows: cranberry extract (Vaccinium macrocarpon extract) having a proanthocyanidin content of 5.0% was used to replace the cranberry fruit powder in Example 1, and was post-added under aDESCRIPTION

[0064] condition where the material temperature was not higher than 35°C. The obtained cranberry extract did not participate in the water extraction and spray-drying steps.

[0065] The conditions and parameters of the remaining steps were the same as those of Example 1.

[0066] Example 3

[0067] This example provides a spleen-strengthening and dampness-dispelling plant instant granule composition, which is prepared from the following raw materials based on 1000 g of preparation charging amount:

[0068] Poria cocos 150 g, coix seed 180 g, dandelion leaf 90 g, com silk 90 g, citrus peel 80 g, cranberry fruit powder 70 g, fennel seed 35 g, resistant dextrin 150 g, maltodextrin 107 g, gum arabic 28 g, hydroxypropyl methyl cellulose 8 g, and silicon dioxide 12 g.

[0069] The parts by weight of the above raw materials charged correspond to: Poria cocos 15 parts, coix seed 18 parts, dandelion leaf 9 parts, corn silk 9 parts, citrus peel 8 parts, cranberry 7 parts, and fennel seed 3.5 parts.

[0070] The preparation method was substantially the same as that of Example 1, and included a water extraction step (SI), a spray-drying step (S2), a roasting and micronization step (S3), a fluidized-bed granulation step (S4), and a low-temperature post-addition and sizing step (S5).

[0071] The main differences from Example 1 were as follows: the roasting temperature of the coix seed was 105°C, and the roasting time was 40 min; the amounts of citrus peel powder and fennel seed powder were increased, with citrus peel being 80 g and fennel seed being 35 g.

[0072] The conditions and parameters of the remaining steps were the same as those of Example 1.

[0073] Comparative Example 1: Ordinary mixed powder

[0074] Compared with Example 1, Comparative Example 1 did not perform water extraction, spray drying, coix seed roasting or fluidized-bed granulation. Poria cocos powder, coix seed powder, dandelion leaf powder, com silk powder, citrus peelDESCRIPTION

[0075] powder, cranberry fruit powder, fennel seed powder and excipients were directly pulverized and mixed, and passed through an 80-mesh sieve, thereby obtaining an ordinary mixed powder.

[0076] This comparative example was used to verify the improvement effects of the water extract! on / spray drying, roasting and micronization, and fluidized-bed granulation processes of the present invention on reconstitution dispersibility and sensory quality.

[0077] Comparative Example 2: Poria cocos and coix seed omitted

[0078] Compared with Example 1, Comparative Example 2 did not contain Poria cocos or coix seed, the missing portion was supplemented with maltodextrin, and the remaining steps were the same.

[0079] This comparative example was used to verify the effect of Poria cocos and coix seed, as basic components for strengthening the spleen and percolating dampness, on improving dampness-heavy bodily sensation.

[0080] Comparative Example 3: Dandelion leaf and corn silk omitted Compared with Example 1, Comparative Example 3 did not contain dandelion leaf or corn silk, the missing portion was supplemented with maltodextrin, and the remaining steps were the same.

[0081] This comparative example was used to verify the auxiliary improvement effect of dandelion leaf and com silk, as auxiliary components for clearing and draining damp turbidity, on indicators related to water-fluid metabolism.

[0082] Comparative Example 4: Citrus peel and fennel seed omitted

[0083] Compared with Example 1, Comparative Example 4 did not contain citrus peel or fennel seed, the missing portion was supplemented with maltodextrin, and the remaining steps were the same.

[0084] This comparative example was used to verify the effect of citrus peel and fennel seed, as components for regulating qi, harmonizing the middle and harmonizing flavor, on improving taste and postprandial abdominal bloating sensation.DESCRIPTION

[0085] Comparative Example 5: Cranberry co-extracted at high temperature Compared with Example 1, in Comparative Example 5, cranberry was subjected to water extraction, concentration and spray drying together with Poria cocos, dandelion leaf and corn silk, the low-temperature post-addition process for cranberry was not adopted, and the remaining steps were the same.

[0086] This comparative example was used to verify the influence of the low-temperature post-addition process for cranberry on the retention rate of polyphenolic components and color.

[0087] Comparative Example 6: All raw materials co-water-extracted and spray-dried

[0088] Compared with Example 1, in Comparative Example 6, Poria cocos, coix seed, dandelion leaf, corn silk, citrus peel, cranberry and fennel seed were all subjected together to water extraction, concentration and spray drying, the staged treatment was not adopted, and the amounts of the remaining excipients were the same as those in Example 1.

[0089] This comparative example was used to verify the advantages of the three-stage segmented treatment process of the present invention over the process in which all raw materials are co-water-extracted and spray-dried.

[0090] Comparative Example 7: Cranberry powder omitted

[0091] Compared with Example 1, Comparative Example 7 did not contain cranberry powder, the missing portion was supplemented with maltodextrin, and the remaining steps were the same.

[0092] This comparative example was used to verify the influence of cranberry powder on sweet-sour flavor harmony and overall acceptability.

[0093] Experimental Example 1: Reconstitution dispersibility test Experimental method: 4.0 g of each sample was added to 200 mL of purified water at 25°C and stirred at a constant speed with a glass rod, and the time required for no obvious large agglomerates to be visually observed was recorded (dispersion time). After stirring for 90 s, the mixture was allowed to stand for 5 min, and theDESCRIPTION

[0094] bottom sediment was collected, dried and weighed; the sedimentation rate was calculated based on the mass of the added sample.

[0095] Experimental results:

[0096] Sample Dispersion time / s 5 min sedimentation Reconstitution state rate / %

[0097] Example 1 58 5.1 No visible lumps Example 2 64 5.8 No visible lumps Example 3 61 5.4 No visible lumps Comparative Example 1 >180 18.9 Obvious floating agglomerates Comparative Example 2 75 7.6 A small amount of fine powder floating Comparative Example 3 82 8.4 A small amount of sediment Comparative Example 4 73 7.0 A small amount of fine powder floating Comparative Example 5 91 8.8 A small amount of agglomerates Comparative Example 6 98 9.5 A small amount of agglomerates and sediment

[0098]

[0099] Comparative Example 7 62 5.7 No visible lumps Experimental conclusion: Examples 1-3 were each capable of forming a relatively uniform dispersion within 90 s, with a sedimentation rate below 6.0%, satisfying the performance indicators. The ordinary mixed powder (Comparative Example 1) and the sample prepared by co-water extraction and spray drying of all raw materials (Comparative Example 6) had significantly poorer dispersibility, indicating that the staged extraction, roasting and micronization, and fluidized-bed granulation processes are conducive to improving the reconstitution palatability of the spleen-strengthening and dampness-dispelling plant granules. After cranberry powder was omitted in Comparative Example 7, the reconstitution dispersibility showed no substantial change, indicating that cranberry powder is mainly used for flavor harmonization and polyphenol stability evaluation, rather than as a key component for improving particle dispersibility.

[0100] Experimental Example 2: Animal evaluation of dampness-heavy state Experimental method: SPF-grade male ICR mice were selected, with 10 mice inDESCRIPTION

[0101] each group. Except for the normal group, all other groups were subjected to continuous modeling for 14 days by a combined method of high-fat feed, damp bedding and low-temperature drinking water, thereby establishing a dampness-heavy-state animal model. After modeling, each sample-administered group was intragastrically administered with the corresponding sample at a dose of 0.8 g / kg bw / day for 7 consecutive days; the normal group and the model group were given an equal volume of purified water. At the end of the test, fecal moisture content, 6 h urine volume, gastric emptying rate and small intestinal propulsion rate were measured, and a dampness-heavy composite score was assigned in combination with activity state, coat state and fecal state.

[0102] The dampness-heavy composite score adopted a 0-10 point scale, with a higher score indicating a more obvious dampness-heavy state. The scoring items included reduced activity, curled-up body or drowsiness manifestation, damp or messy coat, loose stools, and abdominal fullness manifestation after eating.

[0103] Experimental results:

[0104] Group Fecal 6 h urine Gastric Small intestinal Dainpncss-hca\) moisture / % volume / mL / 100 emptying rate / % propulsion / % score

[0105] g

[0106] Normal group 51.8 1.62 63.5 68.4 1.3 Model group 68.6 0.88 42.1 45.7 7.2 Example 1 57.4 1.41 56.8 61.3 2.9 group

[0107] Example 2 58.2 1.35 55.6 59.8 3.2 group

[0108] Example 3 56.9 1.43 57.2 62.1 2.8 group

[0109] Comp. Ex. 1 63.9 1.05 48.3 51.6 5.5 group

[0110] Comp. Ex. 2 65.1 1.12 47.4 50.8 5.8 group

[0111] Comp. Ex. 3 62.7 1.01 50.1 52.3 5.1 group

[0112] Comp. Ex. 4 59.8 1.29 54.4 57.6 4.4 group

[0113] Comp. Ex. 5 58.4 1.38 55.9 60.5 3.3 group

[0114]

[0115] DESCRIPTION

[0116] Group Fecal 6 h urine Gastric Small intestinal Dampness-heavy moisture / % volume / mL / 100 emptying rate / % propulsion / % score

[0117] g

[0118] Comp. Ex. 6 61.9 1.16 49.5 53.2 5.0

[0119]

[0120] group

[0121] Experimental conclusion: The model group showed increased fecal moisture content, decreased 6 h urine volume, decreased gastric emptying rate and decreased small intestinal propulsion rate, with the dampness-heavy composite score increasing to 7.2, indicating successful establishment of the dampness-heavy-state animal model.

[0122] The Example 1-3 groups all improved the above dampness-heavy-state-related indicators, and the dampness-heavy composite scores were 2.9, 3.2 and 2.8, respectively. Compared with the model group (7.2), the differences were statistically significant (P<0.05), indicating that the composition of the present invention has a relatively good improvement effect on states related to excessive internal dampness, such as heaviness, loose-stool sensation and impaired spleen-stomach transportation and transformation.

[0123] After Poria cocos and coix seed were omitted in Comparative Example 2, the dampness-heavy composite score was 5.8, and the effect was significantly decreased, indicating that Poria cocos and coix seed are the basic spleen-strengthening and dampness-dispelling components of the present composition.

[0124] After dandelion leaf and corn silk were omitted in Comparative Example 3, the dampness-heavy composite score was 5.1, and improvement of indicators related to water-fluid metabolism was insufficient, indicating that dandelion leaf and com silk have an auxiliary improvement effect on indicators related to water-fluid metabolism under the dampness-heavy state.

[0125] After all raw materials were co-water-extracted and spray-dried in Comparative Example 6, the dampness-heavy composite score was 5.0, and the improvement effect was weaker than those of Examples 1-3, indicating that the segmented treatment process has a positive effect on maintaining the overall improvement effect of the composition.DESCRIPTION

[0126] Experimental Example 3: Trial-consumption bodily sensation evaluation Experimental method: adult volunteers who self-reported at least three manifestations among body heaviness, postprandial abdominal bloating, sticky sensation in the mouth, loose-stool sensation and drowsiness were selected, with 20 participants in each group. During the trial consumption period, the corresponding sample was consumed once daily, 4.0 g each time, for 14 consecutive days. A 10-point self-rating questionnaire was used to evaluate changes in body heaviness, postprandial abdominal bloating, sticky sensation in the mouth, loose-stool sensation and drowsiness, with a higher score indicating a more obvious bodily sensation. All subjects were adults; during the trial consumption period, they did not use other similar products for dampness dispelling, water-fluid metabolism support or spleen-stomach comfort, and had no serious gastrointestinal disease, kidney disease or ongoing related drug therapy. This evaluation was used only for trial-consumption bodily sensation observation of food and dietary-supplement-type plant products, and did not involve disease diagnosis, treatment or prevention.

[0127] Experimental results:

[0128] Group Body Postprandial Sticky mouth Loose stool Drowsiness Total licav incss bloating sensation

[0129] Example 1 6.8 6.4 6.1 5.9 6.6 31.8 before

[0130] Example 1 3.2 3.1 2.9 3.0 3.4 15.6 after 14 d

[0131] Comp. Ex. 1 6.6 6.3 6.0 5.8 6.5 31.2 before

[0132] Comp. Ex. 1 5.4 5.2 5.1 5.0 5.3 26.0 after 14 d

[0133] Comp. Ex. 2 6.7 6.5 6.2 5.9 6.4 31.7 before

[0134] Comp. Ex. 2 5.8 5.5 5.4 5.2 5.6 27.5 after 14 d

[0135] Comp. Ex. 3 6.6 6.2 6.1 5.7 6.3 30.9 before

[0136] Comp. Ex. 3 5.1 5.0 4.9 4.8 5.2 25.0 after 14 d

[0137]

[0138] Experimental conclusion: the trial-consumption bodily sensation scores beforeDESCRIPTION

[0139] consumption were similar among all groups (total scores 30.9-31.8), and the baselines were consistent.

[0140] After Example 1 was consumed continuously for 14 days, the scores for body heaviness, postprandial abdominal bloating, sticky sensation in the mouth, loose-stool sensation and drowsiness all decreased significantly, and the total score decreased from 31.8 to 15.6, representing an improvement of 51.0%. The total score of the ordinary mixed powder (Comparative Example 1) decreased only from 31.2 to 26.0, representing an improvement of 16.7%. The improvement in total score was 13.3% for Comparative Example 2 lacking Poria cocos and coix seed, and 19.1% for Comparative Example 3 lacking dandelion leaf and corn silk.

[0141] The above results indicate that the component combination and segmented preparation process of the present invention can significantly improve the effect of spleen-strengthening and dampness-dispelling plant products on improving dampness-heavy bodily sensation.

[0142] Experimental Example 4: Relative retention rate test of total cranberry polyphenols

[0143] Experimental method: total polyphenol content was determined by the Folin-Ciocalteu method and expressed as gallic acid equivalents. Taking the initial total polyphenol content of the sample as 100%, the sample was subjected to accelerated storage at 40°C and 75% relative humidity, and the relative retention rates of total polyphenols after 30 days and 60 days were measured, respectively.

[0144] Experimental results:

[0145] Sample 30-day retention rate / % 60-day retention rate / % Color change Example 1 95.2 91.1 Slight change Example 2 94.6 90.4 Slight change Example 3 94.9 90.8 Slight change Comparative Example 5 85.7 77.9 Marked color darkening

[0146]

[0147] Comparative Example 6 84.1 75.6 Marked color darkening Experimental conclusion: Examples 1-3 adopted the low-temperature post-addition process for cranberry (cranberry powder was added after the material temperature was reduced to below 40°C). After 60 days under accelerated storageDESCRIPTION

[0148] conditions, the relative retention rates of total polyphenols were all above 90%, and the color changed only slightly. The 60-day total polyphenol retention rates of Comparative Example 5 (cranberry co-water-extracted at high temperature) and Comparative Example 6 (all raw materials co-water-extracted and spray-dried) were 77.9% and 75.6%, respectively, which were significantly lower than those of the examples, and the color was markedly darkened.

[0149] The above results indicate that the low-temperature post-addition process for cranberry adopted in the present invention can effectively avoid thermal degradation loss of polyphenolic components during high-temperature extraction, and is beneficial for maintaining the stability of cranberry-related components and the color quality of the product.

[0150] Experimental Example 5: Sensory evaluation

[0151] Experimental method: 10 evaluators who had undergone basic screening were selected to evaluate herbal astringency, powderiness, dull grain flavor, sweet-sour harmony and overall acceptability of the reconstituted liquids of the samples. Herbal astringency, powderiness and dull grain flavor were evaluated on a 10-point scale, with a higher score indicating a more obvious unpleasant sensation; sweet-sour harmony and overall acceptability were evaluated on a 10-point scale, with a higher score indicating better acceptability.

[0152] Experimental results:

[0153] Sample Herbal Powdcrincss Dull grain flavor Sweet-sour Overall astringency harmony acceptability Example 1 2.3 2.6 2.4 8.2 8.1 Example 2 2.5 2.8 2.5 8.0 7.9 Example 3 2.1 2.6 2.2 8.3 8.3 Comparative 6.8 7.2 6.4 5.8 4.2 Example 1

[0154] Comparative 6.1 4.2 5.7 6.0 5.1 Example 4

[0155] Comparative 5.0 5.2 4.9 5.6 5.5 Example 6

[0156] Comparative 2.7 2.9 2.6 5.4 6.7

[0157]

[0158] Example 7

[0159] Experimental conclusion: the herbal astringency scores (2.1-2.5), powderinessDESCRIPTION

[0160] scores (2.6-2.8) and dull grain flavor scores (2.2-2.5) of Examples 1-3 were all relatively low, while the sweet-sour harmony (8.0-8.3) and overall acceptability (7.9-8.3) were relatively high.

[0161] The sensory quality of Comparative Example 1 (ordinary mixed powder) was poor in all aspects, and the herbal astringency (6.8), powderiness (7.2) and dull grain flavor (6.4) scores were all significantly higher than those of the examples.

[0162] The herbal astringency (6.1) and dull grain flavor (5.7) scores of Comparative Example 4 (lacking citrus peel and fennel seed) increased significantly, indicating that citrus peel powder and fennel seed powder, as components for regulating qi, harmonizing the middle and harmonizing flavor, have a significant effect on improving the flavor of the spleen-strengthening and dampness-dispelling plant granules.

[0163] The herbal astringency, powderiness and dull grain flavor of Comparative Example 7 (lacking cranberry powder) were comparable to those of the examples, but the sweet-sour harmony (5.4) and overall acceptability (6.7) decreased, indicating that cranberry powder is mainly used to improve sweet-sour flavor harmony and drinking acceptability, rather than serving as a principal dampness-dispelling component.

[0164] Industrial Applicability

[0165] The spleen-strengthening and dampness-dispelling plant instant granule composition provided by the present invention can be prepared using conventional production equipment for food and dietary-supplement-type plant products, including an extraction tank, concentration equipment, spray-drying equipment, pulverization equipment, mixing equipment and fluidized-bed granulation equipment. The obtained granules may be used for preparing solid beverages, granules, stick-pack powders, capsule fillings or other dietary-supplement-type plant products, and are suitable for large-scale production and application.

[0166] The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the art should understand that the present invention is not limited to the above examples; what is described in the aboveDESCRIPTION

[0167] examples and the specification merely illustrates the principles of the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention, and such changes and improvements all fall within the scope of the present invention as claimed.

Claims

CLAIMS1. A spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation, characterized in that the plant instant granule composition comprises: a composite water-extracted spray-dried powder, roasted coix seed micropowder, citrus peel powder, fennel seed powder, cranberry powder and granulation excipients; the composite water-extracted spray-dried powder is prepared by subjecting Poria cocos, dandelion leaf and corn silk to water extraction and concentration, mixing the same with resistant dextrin, maltodextrin and gum arabic, and then spray-drying; the roasted coix seed micropowder is prepared by pulverizing coix seed after low-temperature roasting at 100-130°C for 20-45 min; and the cranberry powder is added after fluidized-bed granulation and when a material temperature is reduced to below 40°C;calculated based on parts by weight of dry raw plant materials charged, the Poria cocos is 18-30 parts, the coix seed is 15-28 parts, the dandelion leaf is 8-16 parts, the com silk is 8-16 parts, the citrus peel is 5-12 parts, the cranberry is 4-10 parts, and the fennel seed is 2-7 parts; a mass ratio of the composite water-extracted spray-dried powder, the roasted coix seed micropowder, the citrus peel powder, the fennel seed powder and the cranberry powder is 35-60:12-25:5-12:2-6:4-10;the granulation excipients comprise resistant dextrin, maltodextrin, gum arabic, hydroxypropyl methylcellulose and silicon dioxide.

2. The spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 1, characterized in that: calculated based on parts by weight of dry raw plant materials charged, the Poria cocos is 20-26 parts, the coix seed is 18-24 parts, the dandelion leaf is 10-14 parts, the corn silk is 10-14 parts, the citrus peel is 7-10 parts, the cranberry is 5-8 parts, and the fennel seed is 3-5 parts.

3. The spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 1, characterized in that: in the composite water-extracted spray-dried powder, calculated by weight of solids before spray drying, water-extracted solids of Poria cocos,CLAIMSdandelion leaf and corn silk account in total for 15-40%, resistant dextrin accounts for 25-55%, maltodextrin accounts for 10-30%, and gum arabic accounts for 3-10%.

4. The spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 1, characterized in that: a D90 particle size of the roasted coix seed micropowder is not greater than 180 pm; and D90 particle sizes of both the citrus peel powder and the fennel seed powder are not greater than 250 pm.

5. The spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 1, characterized in that: the hydroxypropyl methylcellulose is prepared as an aqueous solution having a mass concentration of 2.0-8.0% for use as a fluidized-bed granulation spray liquid.

6. The spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 1, characterized in that: particles of 20-60 mesh in the plant instant granule composition account for not less than 75%; the composition forms a uniform dispersion within 90 s after stirring in water at 25°C, and a sedimentation rate after standing for 5 min is not higher than 8.0%.

7. A preparation method of a spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation, for preparing the spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to any one of claims 1 to 6, characterized in that the preparation method adopts a three-stage process of water extraction and spray drying, roasting and micronization, and low-temperature post-addition, and comprises the following steps:51, taking Poria cocos, dandelion leaf and corn silk, adding water for extraction, filtering, combining filtrates and concentrating the same, thereby obtaining a plant water-extract concentrate;52, adding resistant dextrin, maltodextrin and gum arabic to the plantCLAIMSwater-extract concentrate, homogenizing and then spray-drying, thereby obtaining the composite water-extracted spray-dried powder;53, pulverizing coix seed after low-temperature roasting to obtain the roasted coix seed micropowder; and separately pulverizing citrus peel and fennel seed to obtain citrus peel powder and fennel seed powder;54, mixing the composite water-extracted spray-dried powder, the roasted coix seed micropowder, the citrus peel powder, the fennel seed powder and silicon dioxide, and performing fluidized-bed spray granulation using a hydroxypropyl methylcellulose aqueous solution;55, drying the granulated material and cooling the same to below 40°C, adding cranberry powder, mixing uniformly, and sizing the granules, thereby obtaining the spleen-strengthening and dampness-dispelling plant instant granule composition.

8. The preparation method of the spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 7, characterized in that: in SI, an amount of water added is 8-12 times the total weight of Poria cocos, dandelion leaf and corn silk, an extraction temperature is 75-90°C, and extraction is performed 1-2 times for 60-120 min each time.

9. The preparation method of the spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 7, characterized in that: in S2, an inlet air temperature for spray drying is 150-175°C, and an outlet air temperature is 75-90°C.

10. The preparation method of the spleen-strengthening and dampness-dispelling plant instant granule composition for improving a dampness-heavy bodily sensation according to claim 7, characterized in that: in S4, an inlet air temperature for fluidized-bed granulation is 45-65°C, and a material temperature is 32-45°C; and the obtained spleen-strengthening and dampness-dispelling plant instant granule composition is used in a food, solid beverage, granule, stick-pack powder, capsule filling or dietary-supplement-type plant product for improving a dampness-heavyCLAIMS bodily sensation state for a non-therapeutic purpose.

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