Information processing device, information processing system, and program

Abstract

This information processing device comprises: a first acquisition means for acquiring first authentication information associated with a cancer vaccine; a second acquisition means for acquiring genome information obtained by analyzing a specimen collected from a target patient before administration of the cancer vaccine; a conversion means for converting the genome information into second authentication information; and a comparison means for comparing the first authentication information with the second authentication information.

Description

Information processing apparatus, information processing system, method and program

[0001] The present invention relates to an information processing apparatus, an information processing system, a method, and a program.

[0002] In personalized medicine (for example, personalized cancer vaccine therapy and personalized medicine for autoimmune diseases), there is known a management system that enables grasping the delivery date of an administration product (for example, a vaccine) to be administered to a patient (see Patent Document 1).

[0003] WO2023 / 058625A1

[0004] A problem to be solved by the present disclosure is to prevent wrong administration of cancer vaccines in personalized medicine.

[0005] The information processing apparatus according to the present disclosure comprises: a first acquisition means that acquires first authentication information associated with a cancer vaccine; a second acquisition means that acquires genomic information obtained by analyzing a specimen collected from a target patient at the time of administration of the cancer vaccine; a conversion means that converts the genomic information into second authentication information; and a collation means that collates the first authentication information with the second authentication information.

[0006] The information processing system according to the present disclosure is an information processing system including a sequencer and an information processing apparatus, and comprises: a first acquisition means that acquires first authentication information associated with a cancer vaccine; a second acquisition means that acquires genomic information obtained by analyzing, with the sequencer, a specimen collected from a target patient at the time of administration of the cancer vaccine; a conversion means that converts the genomic information into second authentication information; and a collation means that collates the first authentication information with the second authentication information.

[0007] The method according to the present disclosure is a method executed by a computer, and includes: acquiring first authentication information associated with a cancer vaccine; acquiring genomic information obtained by analyzing a specimen collected from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and collating the first authentication information with the second authentication information.

[0008] The program relating to this disclosure is a program for causing a computer to execute a method, the method comprising: obtaining first authentication information associated with a cancer vaccine; obtaining genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and comparing the first authentication information with the second authentication information.

[0009] This figure illustrates the overview of the information processing system according to this embodiment. This figure shows an example of the functional configuration of the information processing system according to this embodiment. This figure shows an example of the hardware configuration of the gene analysis server according to this embodiment. This figure shows an example of the hardware configuration of the hospital server and hospital terminal according to this embodiment. This flowchart shows an example of the operation of the information processing system according to this embodiment. This figure shows an example of the authentication information database according to this embodiment. This figure shows an example of the display of the authentication information matching results according to this embodiment. This figure shows another example of the display of the authentication information matching results according to this embodiment. This figure shows an example of the display of attribute information according to this embodiment.

[0010] Embodiments of the present invention will be described in detail below with reference to the attached drawings. In each figure, components having equivalent functions are denoted by the same reference numerals, and detailed descriptions of components with the same reference numerals will not be repeated. <Overview of the Information Processing System> Figure 1 is a diagram showing an overview of the information processing system 10 according to this embodiment. Personalized cancer vaccines are designed by analyzing the patient's own tumor cells and genetic information and targeting specific mutations and antigens (neoantigens), and therefore need to be administered to the same patient as the patient from whom the cancer vaccine was based.

[0011] Fingerprint and facial recognition have been proposed as methods for authenticating patients receiving cancer vaccines, but these methods may fail due to skin inflammation or cancer progression.

[0012] On the other hand, according to the information processing system 10 of this embodiment, before administering the cancer vaccine, the authentication information DB is referenced and authentication information (first authentication information) linked to the vaccine ID is obtained. This authentication information is generated from the patient's genome information during the process of designing the cancer vaccine and when the patient is admitted to the hospital to receive the cancer vaccine, so it does not change due to skin inflammation or cancer progression, unlike fingerprint authentication or facial recognition. Then, authentication information (second authentication information) is generated from the genome information of the patient's sample (blood, saliva, hair, other cells, etc.) taken at the time of cancer vaccine administration (for example, 2 to 3 hours before administering the cancer vaccine), and this is compared with the authentication information (first authentication information) obtained from the vaccine DB. If authentication is successful as a result of the comparison, the cancer vaccine will be administered, thus preventing the cancer vaccine from being mistakenly administered to other patients. <Configuration of the Information Processing System> Figure 2 is a diagram showing an example of the functional configuration of the information processing system 10 of this embodiment. In the same figure, each functional unit that performs each function can be said to be a means for performing each function.

[0013] As shown in Figure 2, the information processing system 10 according to this embodiment includes a gene analysis server 1 installed at a gene analysis institution that designs cancer vaccines, a cloud storage 3 in which authentication information linked to cancer vaccines is stored in an authentication information DB, and a hospital server 4 installed at a hospital where target patients receive cancer vaccines.

[0014] The gene analysis server 1, cloud storage 3, and hospital server 4 are connected to each other via a network CN such as the internet, enabling communication between them. The network CN can be either a wired or wireless connection, and the type and form of the connection are not restricted. At least a portion of each device is implemented by a computer (information processing device).

[0015] The gene analysis server 1 is connected to the first analysis device 2 via the communication network of the gene analysis institution. The first analysis device 2 is a gene analysis device, such as a next-generation sequencer (NGS) or a nanopore sequencer (e.g., MinION®). In the cancer vaccine design process, the genome information of the patient sample is analyzed by the first analysis device 2. Since the genome information analyzed by the first analysis device 2 becomes authentication information (reference) stored in the authentication information DB, it is preferable to use a high-precision next-generation sequencer.

[0016] Furthermore, the gene analysis server 1 includes an acquisition unit 1a, a conversion unit 1b, and a storage unit 1c.

[0017] The acquisition unit 1a acquires genomic information (first genomic information), which is the result of the analysis of the patient sample by the first analysis device 2.

[0018] The conversion unit 1b converts (generates) the genome information (first genome information) acquired by the acquisition unit 1a into authentication information (first authentication information). The authentication information includes, for example, an STR (Short Tandem Repeat) profile, a DNA-ID (DNA identifier), an HLA type, and DNA mutation information (e.g., a VCF file). The DNA-ID may be a string formed by concatenating the numerical values ​​of the STR profile (allele 1, allele 2), or it may be a hashed version of this string. The conversion unit 1b combines the STR profile calculated based on the genome information according to a predetermined rule, and then applies a hash function to convert the original genome sequence and STR profile into irreversible identification information (DNA-ID). As a result, raw genome information is not stored in the authentication information DB, and authentication processing can be performed while protecting patient privacy.

[0019] The memory unit 1c stores the genome information (first genome information) acquired by the acquisition unit 1a and the authentication information (first authentication information) converted by the conversion unit 1b.

[0020] Furthermore, the gene analysis server 1 stores the authentication information (first authentication information) converted by the conversion unit 1b in the authentication information DB of the cloud storage 3.

[0021] Figure 6 shows an example of information stored in the authentication information database of cloud storage 3. As shown in Figure 6, the authentication information database stores attribute information of patients who are to be administered the cancer vaccine (patient ID, gender, type of cancer, hospital, etc.), vaccine ID (vaccine identification information), and at least one piece of authentication information (STR profile, DNA-ID, HLA type, mutation information, etc.) in association with each other. Therefore, when administering the cancer vaccine, the authentication information and patient attributes can be identified by referencing the authentication information database using the vaccine ID as a query.

[0022] Returning to Figure 2, the hospital server 4 is connected to the second analysis device 5 via the hospital's communication network. The second analysis device 5 is a gene analysis device, such as a nanopore sequencer or a capillary sequencer. At the time of cancer vaccine administration (for example, 2 to 3 hours before administration), the second analysis device 5 analyzes the genomic information of the patient sample (for example, blood, saliva, hair, other cells, etc.). Since the analysis time of the genomic information by the second analysis device 5 is 2 to 3 hours, it is possible to analyze genomic information in a shorter time than with a next-generation sequencer. Note that the second analysis device 5 does not need to be a sequencer as long as it can rapidly analyze genomic information at the time of cancer vaccine administration.

[0023] Furthermore, the hospital server 4 includes a first acquisition unit 4a, a second acquisition unit 4b, a conversion unit 4c, a determination unit 4d, a matching unit 4e, and an output unit 4f.

[0024] The first acquisition unit 4a acquires authentication information (first authentication information) associated with the cancer vaccine from the authentication information DB. Specifically, the first acquisition unit 4a searches the vaccine DB using the vaccine ID (vaccine identification information) of the cancer vaccine as a query, identifies the authentication information (first authentication information) linked to the vaccine ID, and acquires it. For example, when administering a cancer vaccine, hospital staff may automatically refer to the vaccine DB by reading a barcode, two-dimensional code, etc. attached to the packaging of the cancer vaccine with a scanner or the imaging unit (image sensor 607) of the hospital terminal 6 (see Figure 4).

[0025] The second acquisition unit 4b acquires genomic information obtained by analyzing a sample taken from the target patient at the time of cancer vaccine administration (for example, 2 to 3 hours before cancer vaccine administration). Prior to cancer vaccine administration, the genomic information (second genomic information) of the patient's sample (for example, blood, saliva, hair, or other non-invasive samples such as cells) is analyzed using the second analyzer 5. The second acquisition unit 4b acquires the genomic information (second genomic information) analyzed by the second analyzer 5 from the second analyzer 5.

[0026] The conversion unit 4c converts (generates) the genome information (second genome information) acquired by the second acquisition unit 4b into authentication information (second authentication information). This authentication information corresponds to the authentication information stored in the authentication information DB (STR profile, DNA-ID, HLA type, mutation information, etc.).

[0027] The determination unit 4d determines at least one gene based on the attribute information of the target patient. Here, attribute information includes, for example, the patient ID, gender, cancer type, hospital, etc., stored in the authentication information DB (see Figure 6). In order to shorten the time required for the matching process by the matching unit 4e, it is effective to limit the STR profiles used for matching (authentication). Therefore, the determination unit 4d determines (selects) at least one gene based on the attribute information of the target patient in order to narrow down the STR profiles used for matching (authentication). Specifically, for example, the determination unit 4d determines at least one gene by generating a list of genes (chromosomes) corresponding to the cancer type included in the attribute information. This shortens the time required for the authentication information matching process by the matching unit 4e. In this way, the determination unit 4d reduces the amount of computation and memory usage required for the matching process by the matching unit 4e by significantly reducing the number of genes used for matching based on the attribute information of the target patient compared to the conventional case where the whole genome is used, thereby enabling the matching process to be completed within the limited time before administration.

[0028] The matching unit 4e compares the authentication information (first authentication information) acquired by the first acquisition unit 4a with the authentication information (second authentication information) converted (generated) by the conversion unit 4c. Specifically, the matching unit 4e compares the first authentication information and the second authentication information using one or more pieces of authentication information (STR profile, DNA-ID, HLA type, mutation information, etc.) included in the first authentication information and the second authentication information.

[0029] For example, if an STR profile is used as authentication information, the matching unit 4e may calculate the EV (Evaluation Value) score of the STR profile. In this case, for example, if the EV score is 0.8 or higher, authentication can be determined to be successful (match).

[0030] Furthermore, if DNA-ID, HLA type, or mutation information is used as authentication information, the matching unit 4e may determine whether or not these match.

[0031] Furthermore, the matching unit 4e may perform matching by integrating multiple pieces of authentication information. For example, matching may be performed using an STR profile and HLA type and / or mutation information. In this case, the matching unit 4e may determine that authentication is successful when a certain number (more than half) or all of the authentication information matches. This improves the authentication accuracy compared to using a single piece of authentication information.

[0032] The output unit 4f outputs the verification result from the verification unit 4e. Specifically, the output unit 4f outputs the verification result from the verification unit 4e to the display unit 6a of the hospital terminal 6. The hospital terminal 6 is, for example, a terminal device such as a personal computer, smartphone, or tablet.

[0033] Figure 7 shows an example of the display of matching results shown on the display unit 6a of the hospital terminal 6. As shown in Figure 7, information indicating the matching results is displayed on the screen 60 of the display unit 6a. This information indicating the matching results is presented to the user (hospital staff) via, for example, the UI (user interface) of dedicated application software. In this application software, for example, an overview of the matching results can be displayed on the overview tab 61 page. This overview of the matching results includes an EV display area 61a that displays the EV score of the STR profile, and a list display area 61b that displays a list of the match / mismatch of the STR marker corresponding to each gene determined by the determination unit 4d.

[0034] Figure 8 is a diagram illustrating the detailed information of the matching results displayed on the screen 60 of the display unit 6a. As shown in Figure 8, the page of the details tab 62 in the application software described above includes a DNA-ID display area 62a that displays the DNA-ID by comparing the reference (first authentication information) and the query (second authentication information), an HLA type display area 62b that displays the HLA type by comparing the reference (first authentication information) and the query (second authentication information), a first STR display area 62c that displays the STR profile (STR marker) that matched the reference in a pull-down list format, and a second STR display area 62d that displays the STR profile (STR marker) that did not match the reference in a pull-down list format. In this second STR display area 62d, the parts (alleles) that did not match are highlighted in bold, color, etc. When the relevant part is selected by hovering over it with the mouse or tapping it, the corresponding part of the reference (first authentication information) is displayed on the screen 60 (for example, a pop-up display 62e). In this way, by highlighting the STR markers that do not match in the second STR display area 62d, healthcare professionals can quickly identify the presence and degree of mismatch, thereby reducing the risk of mistakenly continuing administration in the event of authentication failure.

[0035] Figure 9 is a diagram illustrating the attribute information displayed on the screen 60 of the display unit 6a. As shown in Figure 9, the attribute information tab 63 page in the application software described above includes an attribute information display area 63a where the attribute information of the target patient is displayed in a list. The attribute information displayed in this attribute information display area 63a may be obtained from the authentication information DB at the same time as the first acquisition unit 4a acquires the authentication information (first authentication information), and the acquired attribute information may be output to the hospital terminal 6 by the output unit 4f.

[0036] Note that the output destination of the verification results by the output unit 4f is not limited to the hospital terminal 6. For example, the output unit 4f may output the verification results to a display 406 (see Figure 4) connected to the hospital server 4. <Hardware Configuration> Next, the hardware configuration of the information processing system 10 according to this embodiment will be described.

[0037] Figure 3 is a block diagram showing an example of the hardware configuration of the gene analysis server 1 according to this embodiment.

[0038] In the gene analysis server 1, the CPU 101 is a processing unit that controls the operation of the entire gene analysis server 1. The ROM 102 is a non-volatile memory that stores control programs and various data executed by the CPU 101. The RAM 103 is a volatile memory used for the load area and work area of ​​programs executed by the CPU 101. The storage device 104 is a storage means for storing various information, and may be built into the gene analysis server 1 itself or may have a removable storage medium. The communication I / F (interface) 105 is an interface for connecting to the first analysis device 2 and the cloud storage 3. The bus 106 is a bus line that connects each of the above components to each other.

[0039] Figure 4 is a block diagram showing an example of the hardware configuration of a hospital server 4 and a hospital terminal 6.

[0040] In the hospital server 4, the CPU 401 is a processing unit that controls the operation of the entire hospital server 4. The ROM 402 is a non-volatile memory that stores control programs and various data executed by the CPU 401. The RAM 403 is a volatile memory used for the load area and work area of ​​programs executed by the CPU 401. The storage device 404 is a storage means for storing various information, and may be built into the hospital server 4 itself or have a removable storage medium. The input device 405 is a device for users of the hospital server 4 to input information, such as a touch panel or microphone. The display 406 is a display device that displays various information (user interface, etc.). The communication I / F (interface) 407 is an interface for connecting to the second analysis device 5 and the hospital terminal 6. The bus 408 is a bus line that connects each of the above components to each other.

[0041] In the hospital terminal 6, the CPU 601 is a processing unit that controls the operation of the entire hospital terminal 6. The ROM 602 is a non-volatile memory that stores control programs executed by the CPU 601 and various data. The RAM 603 is a volatile memory used for the load area and work area of ​​programs executed by the CPU 601. The storage device 604 is a storage means for storing various information, and may be built into the hospital terminal 6 itself or have a removable storage medium. The input device 605 is a device for the user of the hospital terminal 6 to input information, such as a touch panel or microphone. The display 606 is a display device that displays various information (user interface, etc.). The image sensor 607 is an imaging device that captures images of a subject. The communication I / F (interface) 608 is an interface for connecting to the hospital server 4. The bus 609 is a bus line that connects each of the above components to each other. <Example of operation> Next, an example of the operation of the information processing system 10 will be described. Figure 5 is a flowchart showing an example of the operation of the information processing system 10.

[0042] First, in the gene analysis server 1, the acquisition unit 1a acquires the results of the analysis (first genome information) using the first analysis device (step S1).

[0043] Next, the conversion unit 1b converts (generates) the genome information (first genome information) acquired by the acquisition unit 1a into authentication information (first authentication information) (step S2).

[0044] The authentication information (first authentication information) converted (generated) by the conversion unit 1b is stored in the storage unit 1c (step S3).

[0045] Furthermore, the gene analysis server 1 stores the genome information (first genome information) acquired by the acquisition unit 1a in an authentication information DB (step S4).

[0046] Next, in the hospital server 4, the first acquisition unit 4a acquires the authentication information (first authentication information) from the authentication information DB (step S5).

[0047] Then, the second acquisition unit 4b acquires the result (second genome information) analyzed using the second analysis device 5 (step S6).

[0048] Next, the conversion unit 4c converts the genome information (second genome information) acquired by the second acquisition unit 4b into authentication information (second authentication information) (step S7).

[0049] The determination unit 4d determines at least one gene based on the attribute information of the target patient to whom the cancer vaccine is to be administered (step S8).

[0050] Next, the matching unit 4e matches the first authentication information and the second authentication information (step S9).

[0051] The output unit 4f outputs the matching result obtained by the matching unit 4e to the hospital terminal 6 (step S10).

[0052] Then, in the hospital terminal 6, the matching result is displayed on the display unit (step S11).

[0053] In the examples described above, the program includes a set of instructions (or software code) that, when loaded into a computer, cause the computer to perform one or more of the functions described in the embodiments. The program may be stored on a non-temporary computer-readable medium or a physical storage medium. Examples, but not limited to, include random-access memory (RAM), read-only memory (ROM), flash memory, solid-state drive (SSD) or other memory technologies, CD-ROM, digital versatile disc (DVD), Blu-ray® disc or other optical disc storage, magnetic cassette, magnetic tape, magnetic disk storage or other magnetic storage devices. The program may be transmitted over a temporary computer-readable medium or a communication medium. Examples, but not limited to, include temporary computer-readable medium or a communication medium that includes electrical, optical, acoustic or other forms of propagating signals.

[0054] This disclosure is not limited to the embodiments described above, and may be modified as appropriate without departing from its spirit. Furthermore, this disclosure may be implemented by combining the respective embodiments as appropriate.

[0055] Some or all of the above embodiments may also be described as follows, but are not limited to the following:

[0056] (Appendix A1) An information processing device comprising: a first acquisition means for acquiring first authentication information associated with a cancer vaccine; a second acquisition means for acquiring genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; a conversion means for converting the genomic information into second authentication information; and a matching means for comparing the first authentication information and the second authentication information.

[0057] (Appendix A2) The information processing device according to Appendix A1, wherein the first authentication information and the second authentication information include at least one authentication information from among STR profile, DNA-ID, HLA type, and DNA mutation information.

[0058] (Appendix A3) The information processing apparatus according to Appendix A1 or A2, further comprising a determination means for determining at least one gene based on the attribute information of the target patient, wherein the matching means performs the matching using the STR profile corresponding to the gene.

[0059] (Appendix A4) The matching means performs the matching using multiple authentication pieces of information from the STR profile, DNA-ID, HLA type, and mutation information, as described in any of Appendix A1 to A3.

[0060] (Appendix A5) An information processing apparatus according to any one of Appendix A1 to A4, further comprising an output means for outputting the verification result by the verification means.

[0061] (Appendix A6) The output means is an information processing device as described in Appendix A5, which displays the matching results in a list on a display unit for each gene corresponding to the STR profile.

[0062] (Appendix A7) The genomic information is obtained by analyzing the sample using a nanopore sequencer, as described in any of Appendix A1 to A7.

[0063] (Appendix B1) An information processing system comprising a sequencer and an information processing device, the system comprising: a first acquisition means for acquiring first authentication information associated with a cancer vaccine; a second acquisition means for acquiring genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine with the sequencer; a conversion means for converting the genomic information into second authentication information; and a matching means for comparing the first authentication information and the second authentication information.

[0064] (Appendix B2) The information processing system according to Appendix B1, wherein the first authentication information and the second authentication information include at least one authentication information from among STR profile, DNA-ID, HLA type, and DNA mutation information.

[0065] (Appendix B3) The information processing system according to Appendix B1 or B2, further comprising a determination means for determining at least one gene based on the attribute information of the target patient, wherein the matching means performs the matching using the STR profile corresponding to the gene.

[0066] (Appendix B4) The matching means performs the matching using multiple authentication information from the STR profile, the DNA-ID, the HLA type, and the mutation information, as described in any of the information processing systems described in Appendix B1 to B3.

[0067] (Appendix B5) An information processing system according to any one of Appendix B1 to B4, further comprising an output means for outputting the verification result by the verification means.

[0068] (Appendix B6) The output means is the information processing system described in Appendix B5, which displays the matching results in a list on a display unit for each gene corresponding to the STR profile.

[0069] (Appendix B7) The genomic information is obtained by analyzing the sample using a nanopore sequencer, using the information processing system described in any of Appendix B1 to B7.

[0070] (Appendix C1) A method performed by a computer, comprising: obtaining first authentication information associated with a cancer vaccine; obtaining genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and comparing the first authentication information with the second authentication information.

[0071] (Appendix C2) The method according to Appendix C1, wherein the first authentication information and the second authentication information include at least one authentication information from among STR profile, DNA-ID, HLA type, and DNA mutation information.

[0072] (Appendix C3) The method according to Appendix C1 or C2, further comprising a determination means for determining at least one gene based on the attribute information of the target patient, wherein the matching means performs the matching using the STR profile corresponding to the gene.

[0073] (Appendix C4) The matching means performs the matching using a plurality of authentication pieces of information from the STR profile, the DNA-ID, the HLA type, and the mutation information, according to any one of the methods in Appendix C1 to C3.

[0074] (Appendix C5) The method according to any one of the appendices C1 to C4, further comprising an output means for outputting the matching result by the matching means.

[0075] (Appendix C6) The output means is the method according to Appendix C5, wherein the matching results are displayed in a list on the display unit for each gene corresponding to the STR profile.

[0076] (Appendix C7) The genome information is obtained by analyzing the sample using a nanopore sequencer, according to any one of the methods described in Appendix C1 to C7.

[0077] (Appendix D1) A program for causing a computer to execute a method, the method comprising: obtaining first authentication information associated with a cancer vaccine; obtaining genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and comparing the first authentication information with the second authentication information.

[0078] (Appendix D2) The program described in Appendix D1, wherein the first authentication information and the second authentication information include at least one authentication information from among STR profile, DNA-ID, HLA type, and DNA mutation information.

[0079] (Appendix D3) The program according to Appendix D1 or D2, further comprising a determination means for determining at least one gene based on the attribute information of the target patient, wherein the matching means performs the matching using the STR profile corresponding to the gene.

[0080] (Note D4) The matching means is a program according to any one of Notes D1 to D3, which performs the matching using multiple authentication pieces of information from the STR profile, DNA-ID, HLA type, and mutation information.

[0081] (Note D5) A program according to any one of Notes D1 to D4, further comprising an output means for outputting the verification result obtained by the verification means.

[0082] (Note D6) The output means is the program described in Note D5, which displays the matching results in a list on the display unit for each gene corresponding to the STR profile.

[0083] (Note D7) The genomic information is obtained by analyzing the sample using a nanopore sequencer, using any of the programs described in Notes D1 to D7.

[0084] Although the present invention has been described above with reference to embodiments, the present invention is not limited to the above embodiments. Various modifications to the structure and details of the present invention can be made, as can be understood by those skilled in the art within the scope of the present invention.

Claims

1. An information processing device comprising: a first acquisition means for acquiring first authentication information associated with a cancer vaccine; a second acquisition means for acquiring genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; a conversion means for converting the genomic information into second authentication information; and a matching means for comparing the first authentication information and the second authentication information.

2. The information processing apparatus according to claim 1, wherein the first authentication information and the second authentication information include at least one authentication information from among STR profile, DNA-ID, HLA type, and DNA mutation information.

3. The information processing apparatus according to claim 2, further comprising a determination means for determining at least one gene based on the attribute information of the target patient, wherein the matching means performs the matching using the STR profile corresponding to the gene.

4. The information processing apparatus according to claim 2, wherein the matching means performs the matching using a plurality of authentication pieces of information, including the STR profile, the DNA-ID, the HLA type, and the mutation information.

5. An information processing apparatus according to any one of claims 1 to 4, further comprising an output means for outputting the matching result obtained by the matching means.

6. The information processing apparatus according to claim 5, wherein the output means displays the matching results in a list on a display unit for each gene corresponding to the STR profile.

7. The information processing apparatus according to claim 1, wherein the genome information is obtained by analyzing the sample using a nanopore sequencer.

8. An information processing system comprising a sequencer and an information processing device, the system comprising: a first acquisition means for acquiring first authentication information associated with a cancer vaccine; a second acquisition means for acquiring genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine using the sequencer; a conversion means for converting the genomic information into second authentication information; and a matching means for comparing the first authentication information and the second authentication information.

9. A method performed by a computer, comprising: obtaining first authentication information associated with a cancer vaccine; obtaining genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and comparing the first authentication information with the second authentication information.

10. A program for causing a computer to perform a method, the method comprising: obtaining first authentication information associated with a cancer vaccine; obtaining genomic information obtained by analyzing a sample taken from a target patient at the time of administration of the cancer vaccine; converting the genomic information into second authentication information; and comparing the first authentication information with the second authentication information.

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