Tretinest - three-step topical Anti-aging skin cream system containing estriol and tretinoin

Abstract

This invention relates to a three-step topical skincare system combining estriol and tretinoin for synergistic anti-aging effects. The stepwise increase in tretinoin concentration reduces side effects while maintaining efficacy. Estriol enhances hydration and collagen synthesis, offering improved skin tone and elasticity with better tolerability. The combined effect is superior to either alone.

Description

[0001] Description

[0002] Title of Invention : TretinEst - Three-Step Topical Anti-Aging Skin Cream System Containing Estriol and Tretinoin

[0003] [1]

[0004] Technical Field

[0005] The present invention relates to dermatological compositions used in aesthetic and anti-aging skin treatments. More particularly, it discloses a multi-step topical skincare system that combines estriol and tretinoin in progressively increasing strengths, offering improved anti-aging benefits with unexpectedly reduced irritation compared to tretinoin alone.

[0006] [2]

[0007] Background Art

[0008] Tretinoin is widely recognized for its anti-aging effects, but its use is limited by common side effects such as irritation and peeling. Estriol, a weak estrogen, has been shown to improve skin hydration, elasticity, and collagen synthesis. When combined, these two ingredients appear to produce synergistic anti-aging effects while minimizing the irritation typically associated with tretinoin use.

[0009] [3]

[0010] Summary of Invention

[0011] This invention discloses a three-step topical skincare protocol combining estriol at a fixed dose with escalating concentrations of tretinoin. The goal is to deliver effective anti-aging benefits while reducing skin irritation. The stepped progression allows for gradual tolerance building and sustained improvement in skin quality.

[0012] [4]

[0013] Technical Problem

[0014] Topical tretinoin monotherapy causes irritation, limiting adherence and cosmetic outcomes. Hormonal skin aging in women, especially during perimenopause and menopause, further exacerbates the issue.

[0015] [5]Solution to Problem

[0016] By combining tretinoin with estriol and delivering the formulation in a three-step escalation protocol, this invention reduces tretinoin-related irritation while improving overall skin rejuvenation. Estriol contributes to collagen synthesis and hydration, offering a counterbalance to tretinoin’s drying effects.

[0017] [6]

[0018] Advantageous Effects of Invention

[0019] - Enhanced anti-aging effect through synergistic action

[0020] - Reduced irritation and increased tolerability of tretinoin

[0021] - Higher patient compliance due to phased introduction

[0022] - Improved skin hydration, elasticity, and tone

[0023] [7]

[0024] Brief Description of Drawings

[0025] Fig. 1 illustrates the three-step skincare system. Each step contains a fixed concentration of estriol (0.3%) and increasing concentrations of tretinoin: 0.025%, 0.05%, and 0.1%.

[0026] [8]

[0027] Fig. 1 - Three-Step System Diagram (Black & White)

[0028] This figure illustrates the progression of tretinoin concentration across a fixed estriol dose in a three-phase anti-aging skincare regimen.

Claims

The protocol supports epidermal adaptation and maximizes anti-aging outcomes over 3-8 weeks.[10]ExamplesExample 1 (Step 1): Estriol 0.3%, Tretinoin 0.025%, Glycerin 3%, HA 0.1%, Niacinamide 2%Example 2 (Step 2): Estriol 0.3%, Tretinoin 0.05%, same base Example 3 (Step 3): Estriol 0.3%, Tretinoin 0.1%, same base[11]Industrial ApplicabilityThe invention is applicable in cosmeceutical, dermatological, and aesthetic medical industries for the treatment of aging skin, particularly in peri menopausal and postmenopausal populations.Claims1 . A multi-phase anti-aging skincare system comprising three sequential topical formulations with escalating concentrations of tretinoin and a fixed or adjustable concentration of estriol.

2. The system of claim 1 , wherein the tretinoin concentrations are 0.025%, 0.05%, and 0.1% respectively.

3. The system of claim 1 , wherein the estriol concentration is 0.3%.

4. The system of claim 1 , wherein the estriol concentration ranges between 0.1% and 0.5%.

5. A method for reducing visible signs of skin aging comprising the stepwise application of formulations in claim 1 to a subject in need thereof.

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