A hyaluronic-acid-modified drug-loaded liposomal eye drop for myopia control and its preparation method

Abstract

The present invention provides a hyaluronic acid-modified drug-loaded liposomal ophthalmic solution for myopia control and a method for its preparation, belonging to the field of drug delivery technology. The preparation method for the hyaluronic acid-modified drug-loaded liposomal myopia-control eye drops comprises the following steps: Step 1: examination of the solubilized state of the active pharmaceutical ingredient; Step 2: preparation of the drug-loaded cationic liposomes; Step 3: hyaluronic-acid modification; Step 4: evaluation of hyaluronic acids with different molecular weights; Step 5: preparation of the nanoparticles. The preparation method of the present invention is simple and controllable, suitable for nano-delivery of small-molecule ophthalmic drugs, and exhibits outstanding innovation and valuable potential for practical application and promotion.

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