Single Cell Data Batch Effect Integration Algorithm Patents

The dataset covers 18 patent families in total, and the field is fragmented rather than dominated: the leading assignee holds only 2 of the 18 records. The top 5 assignees combined account for 33.3% of all records, and the top 10 reach 61.1%. This means there is no single gatekeeper controlling the core claim space, though a longer tail of single-filing entrants makes up the rest of the field.

Filings rose from 1 in 2021 to a peak of 6 in 2024, a +500% increase over that three-year span. That is the clearest growth signal in the dataset. Figures for 2025 and 2026 appear lower, but that reflects the roughly 18-month lag between filing a patent and its publication, not an actual slowdown in activity.

Almost nine in ten records, 88.9% of the 18 in scope, are classified under G16B, the bioinformatics subclass, confirming that most claims are computational methods applied to biological data. G06F (general digital data processing) and G06N (AI-based computing) each appear on 50.0% of records, often alongside G16B on the same filing. Classes tied to physical measurement or imaging, such as C12Q, G01N, G02B, G06T and G06V, each cover 11.1% of records or less, marking those as comparatively open areas.

The heaviest concentration of both filings and IPC classification sits in China, which accounts for 15 of the 18 records, with the computational core (G16B, G06F, G06N) most densely claimed. Areas combining single-cell integration with optical systems, image processing or recognition (G02B, G06T, G06V) show only one record each in this dataset, suggesting comparatively thin prior art. A freedom-to-operate search should still be run jurisdiction by jurisdiction rather than assuming uniform density.

WO2025064862A1 describes a module for converting single-cell datasets into transformed bulk-cell datasets, used to augment single-cell data, identify cell type subsets including immune cell subsets, and assess disease-associated factors. It was published on 2025-03-27 and represents one of the more recent filings in this 18-record dataset. Anyone building tools that convert or reconcile single-cell outputs into bulk-equivalent formats should review its specific claim scope before designing similar conversion modules.